CN115054561A - Compound plant extract with acne removing effect and preparation method thereof - Google Patents
Compound plant extract with acne removing effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound plant extract with an acne removing effect and a preparation method thereof, and belongs to the technical field of functional skin care products. The compound plant extract with the acne removing effect is taken as a reference, and mainly comprises the following raw materials in parts by weight: 10-25 parts of a red sage root extract, 10-25 parts of a sophora flavescens root extract, 10-15 parts of a honeysuckle flower extract, 10-15 parts of a chrysanthemum extract, 10-15 parts of an alkali dandelion extract, 10-15 parts of a blackberry lily root extract and 5-10 parts of a mint extract. The invention takes the idea of 'integration, syndrome differentiation and synthesis' of traditional Chinese medicine as guidance, and realizes 'comprehensive, healthy and comprehensive' bacteriostatic and acne-removing effects by promoting blood circulation and removing blood stasis (promoting blood microcirculation), clearing heat and drying dampness (killing parasites and relieving itching, inhibiting bacteria and resisting bacteria), clearing heat and detoxicating (reducing swelling and resolving masses), promoting eruption and relieving exterior syndrome.
Description
Technical Field
The invention relates to the technical field of functional skin care products, and particularly relates to a compound plant extract with an acne removing effect and a preparation method thereof.
Background
Acne, commonly known as acne, is a series of inflammatory reactions caused by the failure of skin to normally discharge oil, is a chronic inflammatory skin symptom generated in the hair follicle sebaceous gland tissue part, and mainly occurs in the areas with vigorous sebum secretion, such as the face, the chest and the back.
Acne has different clinical manifestations, including minor comedones, papules, nodules, cysts and even scars. The pathogenesis of acne is not completely studied, but the following 4 causes are well known: 1) abnormal regulation of sebaceous glands by androgens; 2) abnormal keratinization of sebaceous gland ducts; 3) excessive propagation of propionibacterium acnes; 4) inflammatory immune response.
At present, the acne removing agent is mainly used for removing acne in the market or the raw materials are mainly in the state of water aqua, and the acne removing effect is general; or the long-term use of anti-acne ointment containing antibiotics may cause skin nourishing dependence and aggravate the damage of skin barrier.
Disclosure of Invention
The invention aims to provide a compound plant extract with an acne removing effect and a preparation method thereof, and aims to solve the problems that the existing acne removing product is low in acne removing effect or is dependent on long-term use.
The technical scheme for solving the technical problems is as follows:
the invention provides a compound plant extract with an acne removing effect, which takes the compound plant extract with the acne removing effect as a reference, and mainly comprises the following raw materials in parts by weight: 10-25 parts of a red sage root extract, 10-25 parts of a sophora flavescens root extract, 10-15 parts of a honeysuckle flower extract, 10-15 parts of a chrysanthemum extract, 10-15 parts of an alkali dandelion extract, 10-15 parts of a blackberry lily root extract and 5-10 parts of a mint extract.
Further, in the compound plant extract with the acne removing effect, the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 15-20 parts of salvia miltiorrhiza extract, 15-20 parts of kushen root extract, 12-14 parts of honeysuckle flower extract, 12-14 parts of chrysanthemum extract, 12-14 parts of soda dandelion extract, 12-14 parts of blackberry lily root extract and 7-9 parts of mint extract.
Further, in the compound plant extract with acne removing efficacy, based on the compound plant extract with acne removing efficacy, the compound plant extract with acne removing efficacy mainly comprises the following raw materials in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of sophora flavescens root extract, 15 parts of honeysuckle flower extract, 10 parts of chrysanthemum extract, 10 parts of dandelion extract, 10 parts of blackberry lily root extract and 5 parts of mint extract.
The invention also provides a preparation method of the compound plant extract with the acne removing effect, which comprises the following steps:
cutting and cleaning Saviae Miltiorrhizae radix, radix Sophorae Flavescentis, flos Lonicerae, flos Chrysanthemi, herba Taraxaci, rhizoma Belamcandae and herba Taraxaci, decocting with water for the first time, and filtering to obtain Saviae Miltiorrhizae radix primary extractive solution, radix Sophorae Flavescentis primary extractive solution, flos Lonicerae primary extractive solution, flos Chrysanthemi primary extractive solution, herba Taraxaci primary extractive solution, rhizoma Belamcandae primary extractive solution and herba Taraxaci primary extractive solution;
adding water into the primary extract for a second decoction, and filtering to obtain Saviae Miltiorrhizae radix re-extract, radix Sophorae Flavescentis re-extract, flos Lonicerae re-extract, flos Chrysanthemi re-extract, herba Taraxaci re-extract, rhizoma Belamcandae re-extract and herba Taraxaci re-extract;
steam concentrating the re-extracted liquid, and respectively concentrating and filtering to obtain Saviae Miltiorrhizae radix fluid extract, radix Sophorae Flavescentis fluid extract, flos Lonicerae fluid extract, flos Chrysanthemi fluid extract, herba Taraxaci fluid extract, rhizoma Belamcandae fluid extract and herba Taraxaci fluid extract;
spray drying the fluid extract to obtain Saviae Miltiorrhizae radix extract, radix Sophorae Flavescentis extract, flos Lonicerae extract, flos Chrysanthemi extract, herba Taraxaci extract, rhizoma Belamcandae extract and herba Menthae extract;
the extracts are mixed to obtain the compound plant extract with the acne removing effect.
Further, in the preparation method of the compound plant extract with the acne removing effect, the first decoction is carried out by the following steps: adding 8-12 times of water into the raw materials, soaking for 0.5-2 h, heating to boil, and decocting for 1-4 h.
Further, in the preparation method of the compound plant extract with acne removing efficacy, the operation of decocting for the second time is as follows: adding 6-10 times of water into the primary extract, and heating until boiling, and decocting for 1-3 h.
Further, in the preparation method of the compound plant extract with the acne removing effect, the steam concentration operation is as follows: the steam pressure is controlled to be 0.04-0.1 Mpa, the vacuum degree is controlled to be-0.08-0.04 Mpa, and the concentration temperature is controlled to be 65-75 ℃.
Further, in the preparation method of the compound plant extract with the acne removing effect, the relative density of the fluid extract after steam concentration is 1.08-1.12 g/mL.
Further, in the preparation method of the compound plant extract with the acne removing effect, the spray drying operation is as follows: the inlet air temperature is controlled as follows: 190-200 ℃ and the air outlet temperature is controlled at 95-100 ℃.
Further, in the preparation method of the compound plant extract with the acne removing effect, the primary extract and the secondary extract are filtered by adopting a 100-150-mesh screen;
preferably, the re-extraction solution is filtered by 200-300 meshes of filter cloth before steam concentration and after steam concentration.
The invention has the following beneficial effects:
1. the invention takes the concept of 'integration, syndrome differentiation and synthesis' of traditional Chinese medicine as guidance, and realizes 'comprehensive, healthy and comprehensive' antibacterial and acne-removing effects by promoting blood circulation and removing blood stasis (promoting blood microcirculation), clearing heat and drying dampness (killing parasites and relieving itching, inhibiting bacteria and resisting bacteria), clearing heat and detoxicating (detumescence and resolving masses), promoting eruption and relieving exterior syndrome. According to the formula principle of 'monarch, minister, assistant and guide' in the traditional Chinese medicine, the salvia miltiorrhiza medicinal herbs are taken as monarch drugs, so that the traditional Chinese medicine has the effects of activating blood and removing stasis, stimulating the menstrual flow and relieving pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Tanshinone has anti-androgen and mild estrogen activity, is highly sensitive to acne bacillus, and has antiinflammatory and antiinflammatory effects. Is suitable for various types of acne. The medicine has the functions of promoting blood circulation, removing blood stasis, resisting inflammation and diminishing inflammation; the lightyellow sophora root herbal medicine is used as a ministerial medicine for clearing heat and drying dampness, sterilizing and dispelling yang, and eliminating dampness and inducing diuresis. Honeysuckle, chrysanthemum, dandelion and blackberry lily are used as adjuvant drugs for clearing away heat and toxic materials, eliminating carbuncle and dissipating stagnation, promoting diuresis and treating stranguria, and clearing liver and improving vision. The mint herbal medicine is used as a messenger medicine and has the effects of dispelling wind and heat, clearing head and eyes, promoting eruption, soothing liver and promoting qi circulation and relieving pain.
2. The active substances extracted from the plants are safe and non-irritant to the skin, have good acne removing effect and can be used for a long time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a graph showing a comparison of the facial conditions of a patient before treatment and on days 3 to 5 after treatment in test example 1 of the present invention;
FIG. 2 is a graph showing a comparison of the facial conditions of a patient before treatment and on days 3 to 5 after treatment in test example 2 of the present invention.
Detailed Description
The principles and features of the present invention are described below in conjunction with the embodiments and the accompanying drawings, which are set forth by way of illustration only and are not intended to limit the scope of the invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The scheme of the invention is as follows:
the compound plant extract with the acne removing effect is based on the compound plant extract with the acne removing effect, and mainly comprises the following raw materials in parts by weight: 10-25 parts of a red sage root extract, 10-25 parts of a sophora flavescens root extract, 10-15 parts of a honeysuckle flower extract, 10-15 parts of a chrysanthemum extract, 10-15 parts of an alkali dandelion extract, 10-15 parts of a blackberry lily root extract and 5-10 parts of a mint extract.
Dan Shen is slightly cold in nature and bitter in taste. It enters heart and liver meridians. Has effects of removing blood stasis, relieving pain, promoting blood circulation, relieving dysmenorrhea, clearing heart fire, and relieving restlessness. The Saviae Miltiorrhizae radix extract contains tanshinone I, tanshinone IIAA, tanshinone II B, cryptotanshinone, lithospermic acid B, cryptospironolactone, dihydrotanshinone, salvianic acid B, dihydroisotanshinone I, tanshinol, tanshinolide, tigogenin, beta-sitosterol, stigmasterol, and cryptomeriol.
Ku Shen is cold in nature and bitter in taste. They enter heart meridian, liver meridian, stomach meridian, large intestine meridian and bladder meridian. Has effects of clearing heat and eliminating dampness. The radix Sophorae Flavescentis extract mainly contains various alkaloids, such as dextro-matrine, L-fetuinine, matrine, sophoridine, kushenin, kushenchalcone, luteolin-7-glucoside, 1, 8-cineole, umbelliferone, and dextro-sophocarpol.
Honeysuckle flower, cold in nature, sweet in taste. It enters lung meridian, heart meridian and stomach meridian. Has effects of clearing away heat and toxic materials, and cooling and dispelling pathogenic wind heat. The flos Lonicerae extract contains luteolin, inositol 1%, volatile oil, terpenes, phenolic acid, etc. The beverage contains chlorogenic acid, isochlorogenic acid, ginkgol, beta-sitosterol, stigmasterol-D-glucoside, etc.
Chrysanthemum, slightly cold in nature, sweet and bitter in taste. It enters lung and liver meridians. Has effects of dispelling pathogenic wind, clearing heat away, suppressing hyperactive liver, and improving eyesight. The flos Chrysanthemi extract contains adenine, choline, stachydrine, buddlein, Camphora, Borneolum, luteolin-7-0-rhamnoside, and caryophyllene oxide.
Dandelion, cold in nature, bitter and sweet in taste. It enters liver meridian and stomach meridian. Has the effects of clearing away heat and toxic materials, promoting urination, and resolving hard mass. The herba Taraxaci extract contains taraxasterol, choline, inulin, pectin, taraxasterol, taraxacin, caffeic acid, etc. The effect of the dried whole herb of the dandelion herb is consistent with that of the dandelion herb. The dandelion is generally grown in saline-alkali soil, and the pharmaceutical activity is higher.
She gan, cold in nature and bitter in taste. It enters lung meridian. Has effects of clearing away heat and toxic materials, eliminating phlegm, and relieving sore throat. The rhizoma Belamcandae extract contains tectorigenin, tectorigenin A, irigenin, tectorone, Mangiferin, tectorial aldehyde, tectonol A, and tectoridin B, and optionally tectoridin and oleanolide.
Mint, cool in nature and pungent in flavor. It enters lung and liver meridians. Has effects of dispelling pathogenic wind heat, refreshing head and eyes, and promoting eruption. The mint extract mainly contains volatile oil, and the content of the volatile oil in the mint extract is not less than 0.80% (ml/g) according to the pharmacopoeia of the people's republic of China. And also contains levomenthol, isomenthone, pulegone, menthyl acetate, isorfurin, peppermint isoflavic extract, rosmarinic acid, etc.
The invention takes the idea of 'integration, syndrome differentiation and synthesis' of traditional Chinese medicine as guidance, and realizes 'comprehensive, healthy and comprehensive' bacteriostatic and acne-removing effects by promoting blood circulation and removing blood stasis (promoting blood microcirculation), clearing heat and drying dampness (killing parasites and relieving itching, inhibiting bacteria and resisting bacteria), clearing heat and detoxicating (reducing swelling and resolving masses), promoting eruption and relieving exterior syndrome. According to the formula principle of 'monarch, minister, assistant and guide' in the traditional Chinese medicine, the salvia miltiorrhiza medicinal herbs are taken as monarch drugs, so that the traditional Chinese medicine has the effects of activating blood and removing stasis, stimulating the menstrual flow and relieving pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Tanshinone has anti-androgen and mild estrogen activity, is highly sensitive to acne bacillus, and has antiinflammatory and antiinflammatory effects. Is suitable for various types of acne. The medicine has the functions of promoting blood circulation, removing blood stasis, resisting inflammation and diminishing inflammation; takes lightyellow sophora root herbal medicine as ministerial medicine, has the functions of clearing heat and drying dampness, sterilizing and dispelling yang, and drying dampness and inducing diuresis. Honeysuckle, chrysanthemum, dandelion and blackberry lily are used as adjuvant drugs for clearing away heat and toxic materials, eliminating carbuncle and dissipating stagnation, promoting diuresis and treating stranguria, and clearing liver and improving vision. The mint herbal medicine is used as a guiding drug to disperse wind-heat, clear heat and promote eyesight, promote eruption, sooth liver and promote qi circulation and relieve pain.
A preparation method of a compound plant extract with an acne removing effect comprises the following steps:
(1) carrying out initial extraction: cutting and cleaning the salvia miltiorrhiza, the sophora flavescens roots, the honeysuckle flowers, the chrysanthemum, the dandelion, the blackberry lily roots and the dandelion, adding water respectively for first decoction (the specific operation is that 8-12 times of water is added to the raw materials, the raw materials are soaked for 0.5-2 h and heated to boiling and then decocted for 1-4 h), and filtering out a salvia miltiorrhiza primary extract, a sophora flavescens roots primary extract, a honeysuckle flower primary extract, a chrysanthemum primary extract, an dandelion primary extract, a blackberry lily roots primary extract and a dandelion extract by adopting a 100-150-mesh screen.
(2) And then extracting: adding water into the primary extract for secondary decoction (specifically, adding 6-10 times of water into the primary extract, heating to boil and decocting for 1-3 h), and respectively filtering out a red-rooted salvia root re-extract, a bitter ginseng root re-extract, a honeysuckle flower re-extract, a chrysanthemum re-extract, an alkali dandelion re-extract, a blackberry lily root re-extract and a dandelion re-extract by adopting a 100-150-mesh screen; and standing the extract for 1-2 h.
The invention can effectively extract the active ingredients in the raw materials by adding water for secondary extraction.
(3) Concentration: filtering the re-extraction solution by using 200-300-mesh filter cloth, and then carrying out steam concentration, wherein the steam pressure is controlled to be 0.04-0.1 Mpa, the vacuum degree is controlled to be-0.08-0.04 Mpa, the concentration temperature is controlled to be 65-75 ℃, and filtering by using 200-300-mesh filter cloth respectively to obtain a salvia miltiorrhiza fluid extract, a sophora flavescens ait root fluid extract, a honeysuckle flower fluid extract, a chrysanthemum fluid extract, an alkali dandelion fluid extract, a blackberry lily root fluid extract and a dandelion fluid extract; the relative density of the fluid extract after steam concentration is 1.08-1.12 g/mL.
Under the concentration condition of the invention, the active substances in the extracting solution can be effectively retained, and the inactivation of the active substances caused by the damage of active substance molecular chains due to overlong high temperature time is avoided.
(3) And (3) drying: spray drying the fluid extract, and controlling the air inlet temperature at: 190-200 ℃ and the air outlet temperature is controlled at 95-100 ℃, so as to respectively obtain the salvia miltiorrhiza extract, the sophora flavescens root extract, the honeysuckle flower extract, the chrysanthemum extract, the dandelion extract, the blackberry lily root extract and the mint extract.
The invention adopts a spray drying mode to obtain the powdery extract, and the air inlet temperature is controlled as follows: 190-200 ℃, the air outlet temperature is controlled at 95-100 ℃, the spray drying time is short and fast, generally only 5-15 s is needed, the liquid extract drying device has the characteristic of instantaneous drying (95-98% of water can be evaporated instantaneously), the fluid extract can complete the drying process in a short time, the action time is short, and active substances of the fluid extract are not influenced. The spray drying mode simplifies the whole production process, is simple and convenient to operate and control, is suitable for continuous control production, can dry liquid with the moisture content of 40-90% into powder at one time, reduces the procedures of crushing, screening and the like, and improves the product purity. The dried powdered extract has good dispersibility, fluidity and solubility, and good particle size and looseness. In addition, the water content of the powdered extract can be adjusted within a certain range by changing the operation conditions, and the control and management are convenient.
(4) Mixing: the extracts are mixed to obtain the compound plant extract with the acne removing effect.
The preparation method can extract the active ingredients in the raw materials to the maximum extent, the content of the extracted active matters is 100% in theory, and the active matters prepared by the process are easy to store and transport and are difficult to breed bacteria.
Example 1:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 10 parts of salvia miltiorrhiza extract, 10 parts of sophora flavescens root extract, 10 parts of honeysuckle flower extract, 10 parts of chrysanthemum extract, 10 parts of dandelion extract, 10 parts of blackberry lily root extract and 5 parts of mint extract.
The preparation method of the compound plant extract with the acne removing effect comprises the following steps:
(1) carrying out initial extraction: cutting and cleaning Saviae Miltiorrhizae radix, radix Sophorae Flavescentis, flos Lonicerae, flos Chrysanthemi, herba Taraxaci, rhizoma Belamcandae and herba Taraxaci, adding water, decocting for the first time (specifically: adding 8 times of water, soaking for 0.5 hr, heating to boiling, and decocting for 1 hr), and filtering with 100 mesh sieve to obtain Saviae Miltiorrhizae radix primary extract, radix Sophorae Flavescentis primary extract, flos Lonicerae primary extract, flos Chrysanthemi primary extract, herba Taraxaci primary extract, rhizoma Belamcandae primary extract and herba Taraxaci primary extract.
(2) And then extracting: adding water into the primary extract for secondary decoction (specifically, adding 6 times of water into the primary extract, heating to boil, and decocting for 1h), and filtering with 100 mesh sieve to obtain Saviae Miltiorrhizae radix re-extract, radix Sophorae Flavescentis re-extract, flos Lonicerae re-extract, flos Chrysanthemi re-extract, radix Taraxaci re-extract, rhizoma Belamcandae re-extract and herba Taraxaci re-extract; then the extract is kept still for 1 h.
(3) Concentration: filtering the re-extraction solution with 200 mesh filter cloth, and steam concentrating, wherein the steam pressure is controlled at 0.04Mpa, the vacuum degree is controlled at-0.08 Mpa, the concentration temperature is controlled at 65 deg.C, and filtering with 200 mesh filter cloth respectively to obtain Saviae Miltiorrhizae radix fluid extract, radix Sophorae Flavescentis fluid extract, flos Lonicerae fluid extract, flos Chrysanthemi fluid extract, herba Taraxaci fluid extract, rhizoma Belamcandae fluid extract and herba Taraxaci fluid extract; the relative density of the fluid extract after steam concentration is 1.08 g/mL.
(3) And (3) drying: spray drying the fluid extract, and controlling the air inlet temperature at: controlling the air outlet temperature at 95 ℃ at 190 ℃, and respectively obtaining a salvia miltiorrhiza extract, a sophora flavescens root extract, a honeysuckle flower extract, a chrysanthemum extract, an alkali dandelion extract, a blackberry lily root extract and a mint extract.
(4) Mixing: and mixing the extracts to obtain the compound plant extract with the acne removing effect.
Example 2:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 15 parts of salvia miltiorrhiza extract, 15 parts of sophora flavescens root extract, 12 parts of honeysuckle flower extract, 12 parts of chrysanthemum extract, 12 parts of dandelion extract, 12 parts of blackberry lily root extract and 7 parts of mint extract.
The preparation method of the compound plant extract with the acne removing effect comprises the following steps:
(1) carrying out initial extraction: cutting and cleaning Saviae Miltiorrhizae radix, radix Sophorae Flavescentis, flos Lonicerae, flos Chrysanthemi, herba Taraxaci, rhizoma Belamcandae and herba Taraxaci, adding water, decocting for the first time (specifically: adding 10 times of water, soaking for 1.5 hr, heating to boiling, and decocting for 2 hr), and filtering with 120 mesh sieve to obtain Saviae Miltiorrhizae radix primary extract, radix Sophorae Flavescentis primary extract, flos Lonicerae primary extract, flos Chrysanthemi primary extract, herba Taraxaci primary extract, rhizoma Belamcandae primary extract and herba Taraxaci primary extract.
(2) And then extracting: adding water into the primary extract for secondary decoction (specifically, adding 8 times of water into the primary extract, heating to boil, and decocting for 2h), and filtering with 130 mesh sieve to obtain Saviae Miltiorrhizae radix re-extract, radix Sophorae Flavescentis re-extract, flos Lonicerae re-extract, flos Chrysanthemi re-extract, radix Taraxaci re-extract, rhizoma Belamcandae re-extract and herba Taraxaci re-extract; then the extract is kept stand for 1.5 h.
(3) Concentration: filtering the re-extraction solution with 250 mesh filter cloth, and steam concentrating, wherein steam pressure is controlled at 0.08Mpa, vacuum degree is controlled at-0.06 Mpa, concentration temperature is controlled at 70 deg.C, and 250 mesh filter cloth is respectively adopted to filter to obtain Saviae Miltiorrhizae radix fluid extract, radix Sophorae Flavescentis fluid extract, flos Lonicerae fluid extract, flos Chrysanthemi fluid extract, herba Taraxaci fluid extract, rhizoma Belamcandae fluid extract and herba Taraxaci fluid extract; the relative density of the fluid extract after steam concentration is 1.10 g/mL.
(3) And (3) drying: spray drying the fluid extract, and controlling the air inlet temperature at: 195 deg.C, and controlling air-out temperature at 97 deg.C to obtain Saviae Miltiorrhizae radix extract, radix Sophorae Flavescentis extract, flos Lonicerae extract, flos Chrysanthemi extract, herba Taraxaci extract, rhizoma Belamcandae extract and herba Menthae extract.
(4) Mixing: and mixing the extracts to obtain the compound plant extract with the acne removing effect.
Example 3:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 17 parts of salvia miltiorrhiza extract, 17 parts of sophora flavescens root extract, 13 parts of honeysuckle flower extract, 13 parts of chrysanthemum extract, 13 parts of dandelion extract, 13 parts of blackberry lily root extract and 8 parts of mint extract.
The preparation method of the compound plant extract with acne removing efficacy comprises the following steps:
(1) carrying out initial extraction: cutting and cleaning Saviae Miltiorrhizae radix, radix Sophorae Flavescentis, flos Lonicerae, flos Chrysanthemi, herba Taraxaci, rhizoma Belamcandae and herba Taraxaci, adding water, decocting for the first time (specifically: adding 12 times of water, soaking for 2 hr, heating to boiling, and decocting for 4 hr), and filtering with 150 mesh screen to obtain Saviae Miltiorrhizae radix primary extractive solution, radix Sophorae Flavescentis primary extractive solution, flos Lonicerae primary extractive solution, flos Chrysanthemi primary extractive solution, herba Taraxaci primary extractive solution, rhizoma Belamcandae primary extractive solution and herba Taraxaci primary extractive solution.
(2) And then extracting: adding water into the primary extract for secondary decoction (specifically, adding 10 times of water into the primary extract, heating to boil, and decocting for 3h), filtering with 150 mesh sieve to obtain Saviae Miltiorrhizae radix re-extract, radix Sophorae Flavescentis re-extract, flos Lonicerae re-extract, flos Chrysanthemi re-extract, radix Taraxaci re-extract, rhizoma Belamcandae re-extract and herba Taraxaci re-extract; then the extract is kept still for 2 hours.
(3) Concentration: filtering the re-extraction solution with 300 mesh filter cloth, and steam concentrating, wherein steam pressure is controlled at 0.1Mpa, vacuum degree is controlled at-0.04 Mpa, concentration temperature is controlled at 75 deg.C, and 300 mesh filter cloth is respectively adopted to filter to obtain Saviae Miltiorrhizae radix fluid extract, radix Sophorae Flavescentis fluid extract, flos Lonicerae fluid extract, flos Chrysanthemi fluid extract, herba Taraxaci fluid extract, rhizoma Belamcandae fluid extract and herba Taraxaci fluid extract; the relative density of the fluid extract after steam concentration is 1.12 g/mL.
(3) And (3) drying: spray drying the fluid extract, and controlling the air inlet temperature at: controlling the air outlet temperature at 100 deg.C at 200 deg.C to obtain Saviae Miltiorrhizae radix extract, radix Sophorae Flavescentis extract, flos Lonicerae extract, flos Chrysanthemi extract, herba Taraxaci extract, rhizoma Belamcandae extract and herba Menthae extract.
(4) Mixing: and mixing the extracts to obtain the compound plant extract with the acne removing effect.
Example 4:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of sophora flavescens root extract, 15 parts of honeysuckle flower extract, 10 parts of chrysanthemum extract, 10 parts of dandelion extract, 10 parts of blackberry lily root extract and 5 parts of mint extract.
The preparation method of the compound plant extract with acne removing efficacy of the present example is the same as the preparation method of example 1.
Example 5:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 20 parts of salvia miltiorrhiza extract, 20 parts of sophora flavescens root extract, 14 parts of honeysuckle flower extract, 14 parts of chrysanthemum extract, 14 parts of dandelion extract, 14 parts of blackberry lily root extract and 9 parts of mint extract.
The preparation method of the compound plant extract with acne removing efficacy of the embodiment is the same as the preparation method of the embodiment 2.
Example 6:
the compound plant extract with the acne removing effect of the embodiment takes the compound plant extract with the acne removing effect as a reference, and the compound plant extract with the acne removing effect mainly comprises the following raw materials in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of sophora flavescens root extract, 15 parts of honeysuckle flower extract, 15 parts of chrysanthemum extract, 15 parts of dandelion extract, 15 parts of blackberry lily root extract and 10 parts of mint extract.
The preparation method of the compound plant extract with acne removing efficacy of the embodiment is the same as the preparation method of the embodiment 3.
The compound plant extract with the acne removing effect is used as an active component, and is prepared into facial cleanser, smoothing toner, lotion, cream, essence and facial mask by adopting conventional auxiliary materials and processes for producing skin care products, wherein the addition amount of the compound plant extract is 1-10 wt%.
Test example 1
Patients 1, sex women, age 45 years old, had used hormone-containing cosmetics before treatment, resulting in frequent recurrent acne, red swelling and allergy on the face.
The treatment scheme comprises the following steps: the face is thoroughly cleaned, and after the emulsion added with 1.5 wt% of the compound plant extract with the acne removing effect prepared in example 4 is used, the face condition is obviously improved after the emulsion is continuously used for 3-5 days in the morning and evening every day, and no repeated phenomenon is found after a week of observation. The facial condition before and after 3-5 days of treatment is shown in figure 1, and after 3-5 days of treatment, the facial red swelling subsides, and the allergic symptoms are obviously relieved.
Test example 2
Patient 2, sex woman, age 28 years, had greasy face before treatment, often had pox, and had dark spots.
The treatment scheme comprises the following steps: the face is thoroughly cleaned, and after the facial cream added with 1.5 wt% of the compound plant extract with the acne removing effect prepared in example 4 is used, the acne on the face is reduced after 3-5 days of continuous use once every morning and evening, and the acne disappears after 2 weeks of use. The facial conditions before and 3-5 days of treatment are shown in figure 1, and after 3-5 days of treatment, the back part is fresh and cool, and the pox is obviously reduced in swelling and becomes small.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent replacements, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The compound plant extract with the acne removing effect is characterized by mainly comprising the following raw materials in parts by weight: 10-25 parts of a red sage root extract, 10-25 parts of a sophora flavescens root extract, 10-15 parts of a honeysuckle flower extract, 10-15 parts of a chrysanthemum extract, 10-15 parts of an alkali dandelion extract, 10-15 parts of a blackberry lily root extract and 5-10 parts of a mint extract.
2. The compound plant extract with the acne removing effect according to claim 1, which is based on the compound plant extract with the acne removing effect, and mainly comprises the following raw materials in parts by weight: 15-20 parts of salvia miltiorrhiza extract, 15-20 parts of sophora flavescens root extract, 12-14 parts of honeysuckle flower extract, 12-14 parts of chrysanthemum extract, 12-14 parts of dandelion extract, 12-14 parts of blackberry lily root extract and 7-9 parts of mint extract.
3. The compound plant extract with the acne removing effect according to claim 1, which is based on the compound plant extract with the acne removing effect, and mainly comprises the following raw materials in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of sophora flavescens root extract, 15 parts of honeysuckle flower extract, 10 parts of chrysanthemum extract, 10 parts of dandelion extract, 10 parts of blackberry lily root extract and 5 parts of mint extract.
4. A preparation method of the compound plant extract with acne removing efficacy as claimed in any one of claims 1-3, characterized by comprising the following steps:
cutting and cleaning Saviae Miltiorrhizae radix, radix Sophorae Flavescentis, flos Lonicerae, flos Chrysanthemi, herba Taraxaci, rhizoma Belamcandae and herba Taraxaci, decocting with water for the first time, and filtering to obtain Saviae Miltiorrhizae radix primary extractive solution, radix Sophorae Flavescentis primary extractive solution, flos Lonicerae primary extractive solution, flos Chrysanthemi primary extractive solution, herba Taraxaci primary extractive solution, rhizoma Belamcandae primary extractive solution and herba Taraxaci primary extractive solution;
adding water into the primary extract for a second decoction, and filtering to obtain Saviae Miltiorrhizae radix re-extract, radix Sophorae Flavescentis re-extract, flos Lonicerae re-extract, flos Chrysanthemi re-extract, herba Taraxaci re-extract, rhizoma Belamcandae re-extract and herba Taraxaci re-extract;
steam concentrating the re-extracted liquid, and respectively concentrating and filtering to obtain Saviae Miltiorrhizae radix fluid extract, radix Sophorae Flavescentis fluid extract, flos Lonicerae fluid extract, flos Chrysanthemi fluid extract, herba Taraxaci fluid extract, rhizoma Belamcandae fluid extract and herba Taraxaci fluid extract;
spray drying the fluid extract to obtain Saviae Miltiorrhizae radix extract, radix Sophorae Flavescentis extract, flos Lonicerae extract, flos Chrysanthemi extract, herba Taraxaci extract, rhizoma Belamcandae extract and herba Menthae extract;
the extracts are mixed to obtain the compound plant extract with the acne removing effect.
5. The preparation method of the compound plant extract with the acne removing effect according to claim 4, wherein the first decoction is carried out by: adding 8-12 times of water into the raw materials, soaking for 0.5-2 h, heating to boil, and decocting for 1-4 h.
6. The preparation method of the compound plant extract with the acne removing effect according to claim 4, wherein the second decoction is carried out by the following steps: adding 6-10 times of water into the primary extract, and heating until boiling, and decocting for 1-3 h.
7. The preparation method of the compound plant extract with the acne removing effect according to claim 4, wherein the steam concentration is performed by: the steam pressure is controlled to be 0.04-0.1 Mpa, the vacuum degree is controlled to be-0.08-0.04 Mpa, and the concentration temperature is controlled to be 65-75 ℃.
8. The preparation method of the compound plant extract with the acne removing effect according to claim 7, wherein the relative density of the fluid extract after steam concentration is 1.08-1.12 g/mL.
9. The preparation method of the compound plant extract with the acne removing effect according to claim 4, wherein the spray drying is performed by the following steps: the inlet air temperature is controlled as follows: 190-200 ℃ and the air outlet temperature is controlled at 95-100 ℃.
10. The preparation method of the compound plant extract with the acne removing effect according to claim 4, wherein the primary extract and the secondary extract are filtered by a 100-150 mesh screen;
preferably, the re-extraction solution is filtered by using filter cloth of 200-300 meshes before steam concentration and after steam concentration.
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