CN109966199A - A kind of promoting healing skin care compositions and preparation method thereof - Google Patents

Abstract

The present invention discloses a kind of promoting healing skin care compositions, is made of following components by weight: 2-20 parts of composite vegetables extractives, 0.2-5 parts of biological carbohydrate gums -1,0.2-5 parts of probiotics, 0.05-2 parts of polypeptides, 0.05-2 parts of glycoprotein and surplus auxiliary material；The composite vegetables extractive includes Fructus psidii guajavae immaturus extract, Radix Cynanchi Atrati extract, tea tree hydrosol, tea tree ethereal oil and plant Eradicates acne compound.The promoting healing skin care compositions is by using composite vegetables extractive as effective component, inhibit the growth and breeding of suppurative bacterium, promote the metabolism of cell, while using biological carbohydrate gum -1, probiotic, polypeptide and glycoprotein etc., keeping the moisture of skin, promoting cell neogenesis.The promoting healing skin care compositions is small to the irritation of skin, has preferable repairing performance particularly with the not healing surface of a wound completely.

Description

A kind of promoting healing skin care compositions and preparation method thereof

Technical field

The invention belongs to daily fine chemistry industry product technical fields, and in particular to a kind of promoting healing skin care compositions and its system Preparation Method.

Background technique

Acne is a kind of chronic inflammatory skin of pilosebaceous unit, teenager is mainly apt to occur in, to teenager Psychology and social influence it is very big, but tended to after puberty nature mitigate or recovery from illness.Clinical manifestation is to be apt to occur in facial powder With the characteristics of the pleomorphism skin lesion such as thorn, papule, warts, tubercle.

The common method for treating acne includes local use external drug, takes antibiotic or antiandrogen glucocorticoid Equal products, can come into force in a short time, but when for recurrent exerbation, medication will be apparent from there are drug resistance or side effect, and right In slight or healing stage acne, medication is apparently not most preferred method.

Therefore, people, which are also highly desirable to, is suitable for slight or healing product acne care products, it is desirable that this product is not only With preferable skin effect, while being avoided that the use of hormone, have no adverse reaction, can effectively it is antibacterial, while effectively anti-acne promote Into cytothesis, desalinate acne print, increases skin elasticity.

Summary of the invention

For overcome the deficiencies in the prior art, the first purpose of this invention is that providing one kind effectively slows down acne disease Shape, antibacterial, desalination acne print, with the promoting healing skin care compositions for promoting skin to heal.

Second object of the present invention is to provide for the preparation method of promoting healing skin care compositions.

One of achieving the object of the present invention can be reached by adopting the following technical scheme that:

A kind of promoting healing skin care compositions, is made of following components by weight: 2-20 parts of composite vegetables extractives, 0.2-5 parts of biological carbohydrate gums -1,0.2-5 parts of probiotics, 0.05-2 parts of polypeptides, 0.05-2 parts of glycoprotein and surplus auxiliary material；

The composite vegetables extractive includes Fructus psidii guajavae immaturus extract, Radix Cynanchi Atrati extract, tea tree hydrosol, tea tree ethereal oil and plant Object Eradicates acne compound；

The plant Eradicates acne compound be kuh-seng root extract, Salvia root P.E, houttuynia extract, Baical Skullcap root P.E, It is two or more in Europe dandelion rhizome/root extract and Pogostemon cablin leaf extract.

The promoting healing skin care compositions is using composite vegetables extractive as suppression acne, rush regeneration effective component of chinese medicine, wherein kind In pomegranate berry extract, tannin class rich in, to staphylococcus aureus, shigella flexneri, salmonella, large intestine bar Bacterium has apparent bacteriostasis, and significantly inhibits effect to 5 alpha-reductases, is able to suppress the excessive secretion of grease, eliminates Propionibacterium acnes, effect are rapid, safe；The effect of radix cynanchi atrati (CYNANCHUM ATRATUM) extract is that can promote skin again It is raw, and the migration and update of keratinocyte can be remarkably promoted, show the extraordinary curative effect for promoting wound healing, tool There are good anti-inflammatory, anti-irritant effect, there is the curative effect for promoting wound healing well；Tea tree hydrosol and tea tree ethereal oil all sources It is a kind of natural antibacterial antiphlogistic from Melaleuca alternifolia (MELALEUCA ALTERNIFOLIA) leaf, is conducive to suffer from acne Place forms antibacterial protection layer.

Biological carbohydrate gum -1 be one kind 1% linear poly- polysaccharide viscosity solution, it be by bioprocess technology to plant material into Row bacterial fermentation and obtain.Preferable aquation is provided for skin, biological carbohydrate gum -1 is by competitively inhibiting M.I.F (macrophage migration inhibition factor) promotes passivity macrophage to remove from infected point, to improve the healing of acne skin Ability.

Probiotic plays effect by activating the antibacterial of skin itself to resist effect, has the microorganism screen for strengthening skin Barrier, hence it is evident that improve the skin effect of skin nan orelief.

Polypeptide and glycoprotein can promote cell neogenesis, strengthen skin barrier, resist the damage of external nuisance, accelerate to repair It repairs after process such as after-sun recovery, acne, repaired after the damage of bad cosmetics, increase cytoplasm, keep moisture, reduce moisture Evaporation promotes skin corium fibroblast proliferation, increases skin elasticity, improves microcirculation, promotes metabolic waste discharge, improves skin Matter.

The promoting healing skin care compositions, by using the natural plant composition of pharmacological effect effectively to inhibit acne third The acne that acidfast bacilli, yellow grape ball function makes is reduced to elimination, is promoted keratinocyte migration and update, is passed through biological carbohydrate gum -1 Weaken allergy effect with probiotic, activates the vigor of skin.Polypeptide and glycoprotein promote skin revitalization, strengthen skin barrier, promote It is discharged into metabolic waste, improves skin quality.

Further, the composite vegetables extractive further includes mint extract.Calm and anti-inflammatory of releiving is played with efficiency Effect, in addition can also desalinate acne print, improve skin health state.

Further, in order to improve the survival ability of beneficial bacterium in probiotic, the probiotic is Bacillus acidi lactici malt paste The compound of essence, alpha-glucans oligosaccharides.It or still further, also include chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice.

Specifically, the auxiliary material includes preservative, alcoholic solvent, solubilizer, thickener, pH adjusting agent and water.

Specifically, in order to reduce the promoting healing skin care compositions to the irritation of skin, the preservative is o- cymene- The pure and mild Phenoxyethanol of 5-.

Further, which is made of following components by weight: 1.2-6 parts of plant Eradicates acnes Compound, 0.5-2 parts of Fructus psidii guajavae immaturus extracts, 0.5-3 parts of Radix Cynanchi Atrati extracts, 0.5-3 parts of biological carbohydrate gums -1,0.5-3 parts it is prebiotic Element, 0.1-1 parts of decapeptides -4,0.1-1 parts of glycoprotein, 0.01-0.1 parts of tea tree hydrosols, 0.01-0.1 parts of tea tree ethereal oils, 0.01-0.1 It part peppermint leaf oil, 2-15 parts of alcoholic solvents, 0.1-1 parts of solubilizer, 0.1-0.4 parts of thickeners, 0.1-0.5 portions of preservatives and complements to 100 parts of water；The plant Eradicates acne compound is kuh-seng root extract, Salvia root P.E, houttuynia extract, radix scutellariae extraction It is two or more in object, Europe dandelion rhizome/root extract and Pogostemon cablin leaf extract.

Further, the preservative is made of Phenoxyethanol and o- cymene -5- alcohol by the weight ratio of 10-15:1.

Further, the solubilizer is Cremophor RH40.

The second object of the present invention is realized by following technological means:

A method of it prepares such as above-mentioned promoting healing skin care compositions, which is mentioned by composite plant Take object, biological carbohydrate gum -1, probiotic, polypeptide, glycoprotein, preservative, alcoholic solvent, solubilizer, thickener, pH adjusting agent and water system At；

The following steps are included:

1) water, thickener, part alcoholic solvent and part preservative are added in water phase pot, stirring is warming up to 85-95 DEG C, stirs Mix uniformly heat preservation；

2) cool down, sequentially add remaining alcoholic solvent, composite vegetables extractive, biological carbohydrate gum -1, probiotic, polypeptide, sugar Albumen and solubilizer, stir evenly, and pH adjusting agent and remaining preservative is added, is sufficiently stirred；

3) cool down, filtering, stands defoaming at discharging, obtains promoting healing skin care compositions.

Further, it in step 2), feeds after being cooled to 40-45 DEG C, in step 3), is cooled to 35-38 DEG C of discharging.

Formulation Design Principle of the invention is as follows:

The promoting healing skin care compositions, by using the natural plant composition of pharmacological effect effectively to inhibit acne third The acne that acidfast bacilli, yellow grape ball function makes is reduced to elimination, is promoted keratinocyte migration and update, is passed through biological carbohydrate gum -1 Weaken allergy effect with probiotic, activates the vigor of skin.Polypeptide and glycoprotein promote skin revitalization, strengthen skin barrier, promote It is discharged into metabolic waste, improves skin quality.

Compared with prior art, the beneficial effects of the present invention are:

Promoting healing skin care compositions provided by the invention has using plant extracts, carbohydrate gum, polypeptide, glycoprotein etc. are a variety of Imitate ingredient, from antibacterial, moisturizing, promote cytothesis etc. comprehensive function, effectively inhibit the proliferation, Eradicates acne of harmful bacteria in acne, Desalinate acne print, increase skin elasticity, promotes surface of a wound skin healing.

Specific embodiment

In the following, being described further in conjunction with specific embodiment to the present invention:

In following specific embodiments, used raw material can be obtained by commercially available or conventional research technique.

Wherein tea oil hydrosol is Melaleuca alternifolia (MELALEUCA ALTERNIFOLIA) Ye Shui, and tea essential oil is alternate Leaf cajeputtree (MELALEUCA ALTERNIFOLIA) leaf oil.Preferably tea essential oil is added with tea oil hydrosol by the mass ratio of 1:1 It is added in promoting healing skin care compositions.

The present invention provides a kind of promoting healing skin care compositions, is made of following components by weight: 2-20 parts compound Plant extracts, 0.2-5 parts of biological carbohydrate gums -1,0.2-5 parts of probiotics, 0.05-2 parts of polypeptides, 0.05-2 parts of glycoprotein and surplus Auxiliary material；

The composite vegetables extractive includes Fructus psidii guajavae immaturus extract, Radix Cynanchi Atrati extract, tea tree hydrosol, tea tree ethereal oil and plant Object Eradicates acne compound；

The plant Eradicates acne compound is two or more in following extract: kuh-seng root extract, Salvia root P.E, fish raw meat Careless extract, Baical Skullcap root P.E, Europe dandelion rhizome/root extract and Pogostemon cablin leaf extract.

In the promoting healing skin care compositions of embodiment 1-3, the accounting respectively formed is as shown in the table:

1 embodiment 1-3 of table and comparative example at being grouped as

The method for preparing the promoting healing skin care compositions of embodiment 1-3, comprising the following steps:

1) formula for pressing table 1 prepares to weigh each raw material in formula, is held with vessel that are clean and disinfecting；

2) water, propylene glycol, carbomer and o- cymene -5- alcohol are added in water phase pot, stirring is warming up to 85-95 DEG C, stirs It mixes uniformly, keeps the temperature 30min；

3) it is cooled to 45-50 DEG C, sequentially adds ethyl alcohol, kuh-seng (SOPHORA ANGUSTIFOLIA) root extract, Radix Salviae Miltiorrhizae (SALVIA MILTIORRHIZA) extract, cordate houttuynia (HOUTTUYNIA CORDATA) extract, radix scutellariae (SCUTELLARIA BAICALENSIS) extract, Europe dandelion (TARAXACUM OFFICINALE) rhizome/root extract, Pogostemon cablin (POGOSTEMON CABLIN) leaf extract, guava (PSIDIUM GUAJAVA) berry extract, radix cynanchi atrati (CYNANCHUM ATRATUM) extract, biological carbohydrate gum -1, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, malt paste Essence, Bacillus acidi lactici, decapeptide -4, glycoprotein, Melaleuca alternifolia (MELALEUCA ALTERNIFOLIA) Ye Shui, alternate leaf white thousand Layer (MELALEUCA ALTERNIFOLIA) leaf oil, peppermint (MENTHA ARVENSIS) leaf oil, Cremophor RH40, are stirred It mixes uniformly, triethanolamine, Phenoxyethanol is added, is sufficiently stirred；

4) it is cooled to 35-38 DEG C, filtering, stands defoaming at discharging, obtains promoting healing skin care compositions.

The method for preparing the skin care compositions of comparative example, comprising the following steps:

1) formula for pressing table 1 prepares to weigh each raw material in formula, is held with vessel that are clean and disinfecting；

2) water, propylene glycol, carbomer and o- cymene -5- alcohol are added in water phase pot, stirring is warming up to 85-95 DEG C, stirs It mixes uniformly, keeps the temperature 30min；

3) it is cooled to 45-50 DEG C, ethyl alcohol, Cremophor RH40 is sequentially added, stirs evenly, addition triethanolamine, Phenoxyethanol is sufficiently stirred；

4) it is cooled to 35-38 DEG C, filtering, stands defoaming at discharging, obtains skin care compositions.

Effect assessment

1. biocidal property is tested

Using embodiment 1-3 and the skin care compositions of comparative example, and take commercially available Eradicates acne skin care item as reference substance, Respectively according to the antibacterial product bacteriostasis property experimental method of 4 stripping property of GB15979-20002 appendix C, to E.coli (Escherichia coli), P.aeruginosa (Pseudomonas aeruginosa), C.Albicans (candida albicans), P.acnes (propionibacterium acnes), S.aureus (gold Staphylococcus aureus) and S.epidermidis (staphylococcus epidermis) progress biocidal property test.

As a result as shown in the table:

2 biocidal property test result of table

It tests bacterial spawn (inhibiting rate)	Embodiment 1	Embodiment 2	Embodiment 3	Comparative example	Reference substance
						Escherichia coli	94.23	80.43	74.54	4.43	53.43
Pseudomonas aeruginosa	94.34	84.76	76.89	1.98	56.78
						Candida albicans	95.34	90.33	82.52	5.25	66.64
Propionibacterium acnes	97.65	93.76	90.54	2.25	80.52
						Staphylococcus aureus	96.34	91.32	86.44	7.22	83.12
Staphylococcus epidermis	95.32	90.34	89.11	4.54	74.23

From the above experimental results, the promoting healing skin care compositions that embodiment 1-3 is obtained, effective component relative amount is most The crucial venereal bacteria propionibacterium acnes of acne symptom can also be reached nearly 90% inhibiting rate by low embodiment 3, and relative to The embodiment 1 of high concentration can reach 97% or more inhibiting rate.Comparative example is auxiliary material empty map, substantially unrestraint effect, city Reference substance on face also can only achieve 80% or so inhibiting rate.Meanwhile the skin care compositions dialogue that the present embodiment 1-3 is obtained is read Pearl bacterium, staphylococcus aureus and staphylococcus epidermis etc. easily cause the inhibiting rate of the bacterium of wound infection 80% or more. Especially for Escherichia coli and Pseudomonas aeruginosa, inhibiting rate compared to reference substance on the market less than 60%, the present invention is provided Promoting healing skin care compositions can reach the inhibiting rate of 75-94%.

2, cell Proliferation detects

Using EdU cell Proliferation detection method, embodiment 1-3, comparative example and reference substance are added in culture medium, set It is incubated for people under fixed condition and immortalizes epidermal cell (HaCat), by detecting the EdU during penetrating into DNA replication dna in HaCat, by Fluorescence detection tool can accurately detect the cell being newly proliferated, and express statistic is in the percentage of cells of S phase, and then analyzes Cell proliferative conditions.

Test result is as follows shown in table:

3 cell Proliferation testing result of table

Sample	Embodiment 1	Embodiment 2	Embodiment 3	Comparative example	Reference substance
						Proliferation rate %	60	53	46	2	4

As seen from the above table, reference substance on the market is difficult to be proliferated HaCat, and promoting healing skin care provided by the present application The proliferation rate that composition can make HaCat reach 46-60%.As it can be seen that promoting healing skin care compositions provided by the present application can effectively promote Into skin self-regeneration, surface of a wound skin is promoted quickly to heal.

3, skin elasticity is tested

Female volunteers of 10 ages between 28~50 years old are convened, delimit 5 2cm in two cheeks and forehead²Subregion, The random skin care compositions for using embodiment 1-3, comparative example and reference examples, subject's daily night using once, use every time Mung bean grain size is tested using German MAP580 skinanalysis apparatus, comprehensive to obtain positioning elastic part amount of tension Ue, and data value is got over Height indicates that skin elasticity is better.Test result is as follows table:

The setting of 4 skin elasticity of table

Sample	Before use	After 2 weeks	After 4 weeks
				Embodiment 1	0.356	0.449	0.543
Embodiment 2	0.286	0.413	0.454
				Embodiment 3	0.321	0.386	0.412
Comparative example	0.283	0.285	0.283
				Reference substance	0.324	0.331	0.335

By embodiment 1-3 it is found that promoting healing skin care compositions provided by the invention compared with comparative example and reference substance, Relative to comparative example or reference substance, moisture of skin can be effectively kept, keeps skin more flexible.

4, skin smoothness change rate is tested

Female volunteers of 10 ages between 28~50 years old are convened, without obvious acne inflammation phenomenon, but there are acne prints Situation delimit 5 2cm in two cheeks and forehead²Subregion, it is random to use embodiment 1-3, the skincare composition of comparative example and reference examples Object, subject use once every night, are used continuously 30 days, and other any products are not used during test.In environment temperature 25 ± 1 DEG C, it under the conditions of humidity 50 ± 5%, is tested using VISIA face-image analyzer, comprehensive to obtain smoothness data, data value is got over Height indicates that skin smoothness is poorer.Test result is as follows table:

5 skin smoothness change rate of table

Sample	Before use	After use
			Embodiment 1	3.2321	1.5342
Embodiment 2	3.2413	1.6443
			Embodiment 3	2.9313	1.7436
Comparative example	2.9543	2.9356
			Reference substance	2.9853	2.9643

As seen from the above table, reference substance and comparative example, acne print, which there is no, to be improved, the smoothness of skin substantially without Variation.And the promoting healing skin care compositions that embodiment 1-3 is provided, skin smoothness significantly improve, acne print symptom has obtained obviously Ground improves.

For those skilled in the art, it can make other each according to the above description of the technical scheme and ideas Kind is corresponding to be changed and deforms, and all these change and deform the protection model that all should belong to the claims in the present invention Within enclosing.

Claims (10)

1. a kind of promoting healing skin care compositions, which is characterized in that be made of following components by weight: 2-20 parts of compound plants Object extract, 0.2-5 parts of biological carbohydrate gums -1,0.2-5 parts of probiotics, 0.05-2 parts of polypeptides, 0.05-2 parts of glycoprotein and surplus Auxiliary material；

The composite vegetables extractive includes Fructus psidii guajavae immaturus extract, Radix Cynanchi Atrati extract, tea tree hydrosol, tea tree ethereal oil and plant Eradicates Acne compound；

The plant Eradicates acne compound is kuh-seng root extract, Salvia root P.E, houttuynia extract, Baical Skullcap root P.E, Ou Pu It is two or more in Radix Herba Taraxaci stem/root extract and Pogostemon cablin leaf extract.

2. a kind of promoting healing skin care compositions as described in claim 1, which is characterized in that the composite vegetables extractive also wraps Include mint extract.

3. a kind of promoting healing skin care compositions as described in claim 1, which is characterized in that the probiotic be Bacillus acidi lactici, The compound of maltodextrin, alpha-glucans oligosaccharides.

4. a kind of promoting healing skin care compositions as described in claim 1, which is characterized in that the auxiliary material includes preservative, alcohol Solvent, solubilizer, thickener, pH adjusting agent and water.

5. a kind of promoting healing skin care compositions as claimed in claim 4, which is characterized in that the preservative is o- cymene- The pure and mild Phenoxyethanol of 5-.

6. a kind of promoting healing skin care compositions as described in claim 1, which is characterized in that by following components by weight It is made: 1.2-6 parts of plant Eradicates acne compounds, 0.5-2 parts of Fructus psidii guajavae immaturus extracts, 0.5-3 parts of Radix Cynanchi Atrati extracts, 0.5-3 parts of lifes Object carbohydrate gum -1,0.5-3 part probiotic, 0.1-1 parts of decapeptides -4,0.1-1 parts of glycoprotein, 0.01-0.1 parts of tea tree hydrosols, 0.01- 0.1 part of tea tree ethereal oil, 0.01-0.1 parts of peppermint leaf oils, 2-15 parts of alcoholic solvents, 0.1-1 parts of solubilizer, 0.1-0.4 parts of thickeners, 0.1-0.5 portions of preservatives and the water for complementing to 100 parts；The plant Eradicates acne compound be kuh-seng root extract, Salvia root P.E, It is houttuynia extract, Baical Skullcap root P.E, two or more in Europe dandelion rhizome/root extract and Pogostemon cablin leaf extract.

7. a kind of promoting healing skin care compositions as claimed in claim 6, which is characterized in that the preservative by Phenoxyethanol and O- cymene -5- alcohol is formed by the weight ratio of 10-15:1.

8. a kind of promoting healing skin care compositions as claimed in claim 6, which is characterized in that the solubilizer is PEG-40 hydrogenation Castor oil.

9. a kind of method for preparing promoting healing skin care compositions, which is characterized in that the promoting healing skin care compositions is by composite plant Extract, biological carbohydrate gum -1, probiotic, polypeptide, glycoprotein, preservative, alcoholic solvent, solubilizer, thickener, pH adjusting agent and water It is made；

The following steps are included:

1) water, thickener, part alcoholic solvent and part preservative are added in water phase pot, stirring is warming up to 85-95 DEG C, and stirring is equal It is even, heat preservation；

2) cool down, sequentially add remaining alcoholic solvent, composite vegetables extractive, biological carbohydrate gum -1, probiotic, polypeptide, glycoprotein And solubilizer, it stirs evenly, pH adjusting agent and remaining preservative is added, is sufficiently stirred；

3) cool down, filtering, stands defoaming at discharging, obtains promoting healing skin care compositions.

10. method as claimed in claim 9, which is characterized in that in step 2), feed after being cooled to 40-45 DEG C, step 3) In, it is cooled to 35-38 DEG C of discharging.