CN105362143A - Acne-removing essence and preparation method thereof - Google Patents
Acne-removing essence and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention relates to acne-removing essence and a preparation method thereof. The acne-removing essence comprises a component A, a component B, a component C, a component D and a component E, wherein the component A comprises water, allantoin and polyglutamic acid, the component B comprises propylene glycol and methylparaben, the component C comprises hydroxyethyl cellulose and water, the component D comprises salicylic acid and propylene glycol, and the component E comprises sophocarpidine, flos chrysanthemi indici extract and bronopol. The acne-removing essence has the beneficial effects that moisturizing ingredients added into the acne-removing essence are capable of controlling greases to make the skin keep in a normal moisturized state and activating the skin to restore and improve immunocompetence of the skin; antibacterial and bactericidal agents added into the acne-removing essence are capable of killing parasitic bacteria in the skin rapidly; under the synergistic action of various raw materials, the acne-removing essence is capable of speeding up keratinocyte metabolism comprehensively, peeling off dead skin on the epidermal layer, dissolving oil dirt, dredging hair follicle and completely eradicating the acne growing root so as to make the skin restore to health.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of anti-acne essence and preparation method thereof.
Background technology
Anti-acne is the process using Medical Technology or method to eliminate pox, and pox is cried again " skin sore " or " acne ", is a kind of dermatosis because hair follicle and sebaceous gland obstruction, inflammation cause.During adolescence, the hormone meeting stimulating hair growth in body, promote smegma more heavy wool fat, therefore hair and sebaceous gland pile up many materials.In order to cater to the demand of the vast personage that likes to be beautiful, product for resolving poxes on the market gets more and more at present, but uses the composition such as hormone, antibiotic in a lot of product for resolving poxes, and zest is larger, easily causes skin to the drug resistance of Propiobacterium.
Chinese patent CN104997719A discloses a kind of anti-acne essence, the raw materials by weight meter of this anti-acne essence comprises following component: Aloe extraction solution 5-10%, Herba Lysimachiae foenum-graeci quintessence oil 1-5%, water soluble Margarita ultrafine powder 0.5-1%, rose ethereal oil 3-10%, Spirulina powder 3-10%, salicylic acid 0.5-1%, chrysanthemum essential oil 1-5%, Semen Vitis viniferae extract 1-5%, Radix Angelicae Dahuricae extract 1-5%, Flos Lonicerae extract 3-10%, extract solution of bamboo leaves 3-10%, collagen protein 1-3%, hyaluronic acid 1-5%, Radix Paeoniae Alba extract 3-10%, glycerol 1-3%, polyglutamic acid 0.5-1%, surplus is deionized water water.The preparation method of this anti-acne essence comprises the following steps: (1) measures Aloe extraction solution, water soluble Margarita ultrafine powder, Spirulina powder, salicylic acid, Semen Vitis viniferae extract, Radix Angelicae Dahuricae extract, Flos Lonicerae extract, extract solution of bamboo leaves, Radix Paeoniae Alba extract are inserted in deionized water, stirs; (2) measure insert Herba Lysimachiae foenum-graeci quintessence oil, rose ethereal oil, chrysanthemum essential oil, collagen protein, hyaluronic acid, glycerol, polyglutamic acid insert in deionized water, stir and obtain anti-acne essence.
Summary of the invention
In order to solve the problem that anti-acne in prior art not exclusively has pox to print, the invention provides a kind of energy anti-acne and anti-acne essence of pox print and preparation method thereof can be removed.
The technical solution adopted in the present invention is:
A kind of anti-acne essence, comprises following component: component A, B component, component C, D component, component E;
Described component A comprises following weight parts raw material: water 60-100 part, allantoin 0.6-2.4 part, polyglutamic acid 0.05-0.2 part;
Described B component comprises following weight parts raw material: propylene glycol 1-4 part, methyl hydroxybenzoate 0.1-0.3 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.2-0.8 part, water 8-12 part;
Described D component comprises following weight parts raw material: salicylic acid 0.5-2 part, propylene glycol 2-8 part;
Described component E comprises following weight parts raw material: matrine 0.25-1 part, Flos Chrysanthemi Indici extract 1-4 part, Bronopol 0.02-0.1 part.
Further, the weight portion of each component of described anti-acne essence is:
Described component A comprises following weight parts raw material: 80 parts, water, allantoin 1.2 parts, polyglutamic acid 0.1 part;
Described B component comprises following weight parts raw material: propylene glycol 2 parts, methyl hydroxybenzoate 0.2 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.4 part, 10 parts, water;
Described D component comprises following weight parts raw material: salicylic acid 1 part, propylene glycol 4 parts;
Described component E comprises following weight parts raw material: matrine 0.5 part, Flos Chrysanthemi Indici extract 2 parts, Bronopol 0.05 part.
Further, described Flos Chrysanthemi Indici extract is one or more the mixture in Flos Chrysanthemi Indici lactone, bitter principle, chrysol, chrysanthone, northern Camphora, Chrysanthemin.
Further, the preparation method of above-mentioned anti-acne essence comprises the following steps:
(1) by admixed together for each for component A raw material, heat and stir, obtaining A phase;
(2) by admixed together for each for B component raw material, heat and stir, obtaining B phase, then B being added in A phase, stirring, obtain AB mixed phase;
(3) by admixed together for each for component C raw material, heat and stir, obtaining C phase, then C being added in AB mixed phase, stirring, obtain ABC mixed phase;
(4) by admixed together for each for D component raw material, stir, obtain D phase, then D is added in ABC mixed phase, stir, obtain ABCD mixed phase;
(5) component E joined in ABCD mixed phase, stir to obtain anti-acne essence.
Preferably, under the condition of 80-85 DEG C, be stirred to each raw material dissolve admixed together for each for component A raw material completely in step (1).
Preferably, in step (2), each for B component raw material is mixed and under the condition of 65-75 DEG C, be stirred to each raw material dissolve completely.
Preferably, in step (3), each for component C raw material is mixed and under the condition of 55-65 DEG C, be stirred to each raw material dissolve completely.
Preferably, when the temperature of ABC mixed phase being down to 45-50 DEG C in step (4), then D component is added.
Preferably, in step (5), each raw material of component E is joined in ABCD mixed phase respectively.Add respectively and can prevent raw material conglomeration.
Preferably, in step (5) after each raw material of component E adds, under the condition of 100-300r/min, stir 15min, obtain anti-acne essence.
Allantoin is a kind of nontoxic, tasteless, nonirritant, without hypersensitive white crystal.The physiological functions such as allantoin has Promote cell's growth, accelerating wound, horny layer softening albumen are good consolidant and the antiulcer agents of skin trauma.Because allantoin is a kind of amphoteric compound, can in conjunction with many kinds of substance formed double salt, have lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, can make skin keep moisture content, moisten and soft.
Polyglutamic acid, also known as natto gum, is a kind of water solublity, biodegradation, not containing toxicity, uses the biopolymer that microbe fermentation method is obtained.Due to the molecular structure that polyglutamic acid is special, make it have extremely strong moisture-retaining capacity, effectively can increase the moisture-retaining capacity of skin, promote skin health.
Propylene glycol is a kind of chemical reagent, is mainly used in the solvent of various spice, pigment, antiseptic, and the food additive that antiseptic, pigment, antioxidant etc. can be insoluble in water is dissolved in wherein, has stronger moisturizing and freeze proof.
Hydroxyethyl-cellulose is a kind of white or faint yellow, and tasteless, nontoxic threadiness or pulverulent solids, have the characteristic of good thickening, suspension, dispersion, emulsifying, bonding, film forming, protection moisture.
Salicylic acid is a kind of fat-soluble organic acid, and Chang Zuowei cosmetics preservative uses, and it removes the function of fetid sweat, relieving itching and eliminating swelling, analgesic antiphlogistic in addition except antisepsis and sterilization effect.
Matrine is made up through organic solvent extraction such as ethanol of the dry root of leguminous plant Radix Sophorae Flavescentis, plant, fruit, is alkaloid.There is whitening, antiinflammatory, anti-pox, the multiple effectiveness such as antibacterial.
Flos Chrysanthemi Indici extract is the head inflorescence of feverfew Herba Dendranthematis indici, HERBA CHRYSANTHEMI LAVANDULAEFOLII or lavandulaleaf dendranthema herb, has the effect of anti-bacteria and anti-virus, heat clearing and inflammation relieving, antioxidation prevention skin aging.
Bronopol, chemical name 2-bromo-2-nitro-1,3-propylene glycol, white or pale yellow crystals type powder, can at cream frost, use in emulsion, to skin and mucosa without any stimulation, has good fungistatic effect.
Beneficial effect of the present invention is:
The moisturizing ingredient added in anti-acne essence of the present invention, as: allantoin, propylene glycol, polyglutamic acid and hydroxyethyl-cellulose can control oils and fats makes skin keep normal wetting state, the drying become to prevent skin, activates skin simultaneously, recovers and promote the immunocompetence of skin; The salicylic acid added in anti-acne essence of the present invention, matrine, Flos Chrysanthemi Indici extract, Bronopol have good antibacterial, bactericidal action, the parasitic flora can killed rapidly in skin prevents growing of antibacterial and the long pox of inflammation, each raw material of anti-acne essence of the present invention merges, play collaborative effect, can comprehensively accelerator angle cell plastid metabolism, peel off top layer dead bark, dissolve grease, dredging hair follicle, stop the root of pox growth, skin is got well.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
In the present invention, if not refer in particular to, all parts are unit of weight g, and all raw materials etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1
A kind of anti-acne essence, comprises following component: component A, B component, component C, D component, component E;
Described component A comprises following weight parts raw material: 60 parts, water, allantoin 0.6 part, polyglutamic acid 0.05 part;
Described B component comprises following weight parts raw material: propylene glycol 1 part, methyl hydroxybenzoate 0.1 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.2 part, 8 parts, water;
Described D component comprises following weight parts raw material: salicylic acid 0.5 part, propylene glycol 2 parts;
Described component E comprises following weight parts raw material: matrine 0.25 part, Flos Chrysanthemi Indici extract 1 part, Bronopol 0.02 part.
The preparation method of above-mentioned anti-acne essence comprises the following steps:
(1) under the condition of 80 DEG C, be stirred to each raw material dissolve admixed together for each for component A raw material completely, obtain A phase.
(2) each for B component raw material is mixed under the condition of 65 DEG C, be stirred to each raw material dissolve completely, obtain B phase, then B is added in A phase, stir, obtain AB mixed phase;
(3) each for component C raw material is mixed under the condition of 55 DEG C, be stirred to each raw material dissolve completely, obtain C phase, then C is added in AB mixed phase, stir, obtain ABC mixed phase;
(4) by admixed together for each for D component raw material, stir, obtain D phase, when the temperature of ABC mixed phase is down to 45 DEG C, then D is added in ABC mixed phase, stir, obtain ABCD mixed phase;
(5) component E is joined in ABCD mixed phase, under the condition of 100r/min, stir 15min, obtain anti-acne essence.
Embodiment 2
A kind of anti-acne essence, comprises following component: component A, B component, component C, D component, component E;
Described component A comprises following weight parts raw material: 80 parts, water, allantoin 1.2 parts, polyglutamic acid 0.1 part;
Described B component comprises following weight parts raw material: propylene glycol 2 parts, methyl hydroxybenzoate 0.2 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.4 part, 10 parts, water;
Described D component comprises following weight parts raw material: salicylic acid 1 part, propylene glycol 4 parts;
Described component E comprises following weight parts raw material: matrine 0.5 part, Flos Chrysanthemi Indici extract 2 parts, Bronopol 0.05 part.
The preparation method of above-mentioned anti-acne essence comprises the following steps:
(1) under the condition of 82 DEG C, be stirred to each raw material dissolve admixed together for each for component A raw material completely, obtain A phase.
(2) each for B component raw material is mixed under the condition of 70 DEG C, be stirred to each raw material dissolve completely, obtain B phase, then B is added in A phase, stir, obtain AB mixed phase;
(3) each for component C raw material is mixed under the condition of 60 DEG C, be stirred to each raw material dissolve completely, obtain C phase, then C is added in A, B mixed phase, stir, obtain ABC mixed phase;
(4) by admixed together for each for D component raw material, stir, obtain D phase, when the temperature of ABC mixed phase is down to 47 DEG C, then D is added in ABC mixed phase, stir, obtain ABCD mixed phase;
(5) each for component E raw material is joined in ABCD mixed phase, under the condition of 200r/min, stir 15min, obtain anti-acne essence.
Embodiment 3
A kind of anti-acne essence, comprises following component: component A, B component, component C, D component, component E;
Described component A comprises following weight parts raw material: 100 parts, water, allantoin 2.4 parts, polyglutamic acid 0.2 part;
Described B component comprises following weight parts raw material: propylene glycol 4 parts, methyl hydroxybenzoate 0.3 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.8 part, 12 parts, water;
Described D component comprises following weight parts raw material: salicylic acid 2 parts, propylene glycol 8 parts;
Described component E comprises following weight parts raw material: matrine 1 part, Flos Chrysanthemi Indici extract 4 parts, Bronopol 0.1 part.
The preparation method of above-mentioned anti-acne essence comprises the following steps:
(1) under the condition of 85 DEG C, be stirred to each raw material dissolve admixed together for each for component A raw material completely, obtain A phase.
(2) each for B component raw material is mixed under the condition of 75 DEG C, be stirred to each raw material dissolve completely, obtain B phase, then B is added in A phase, stir, obtain AB mixed phase;
(3) each for component C raw material is mixed under the condition of 65 DEG C, be stirred to each raw material dissolve completely, obtain C phase, then C is added in AB mixed phase, stir, obtain ABC mixed phase;
(4) by admixed together for each for D component raw material, stir, obtain D phase, when the temperature of ABC mixed phase is down to 50 DEG C, then D is added in ABC mixed phase, stir, obtain ABCD mixed phase;
(5) each for component E raw material is joined in ABCD mixed phase, under the condition of 300r/min, stir 15min, obtain anti-acne essence.
The case study on implementation of embodiment 2 anti-acne essence:
Choose the patient that 200 examples have pox and pox print on the face, after sooner or later clean, smear anti-acne essence of the present invention in pox and pox print place, 200 routine patients the diet smeared during anti-acne essence of the present invention and living habit with smear anti-acne essence of the present invention before identical; Experimental result: cure 96%, effective 100%.
Cure: pox and pox print all disappear on the face;
Effective: pox disappears on the face, but there is light pox print;
Invalid: pox or the basic no change of pox print on the face.
Summer, female, 18 years old, length has comedo on the face, repetitious the playing of comedo disappears, and disappears, also to leave a lot of pox print on the face, after smearing this invention anti-acne essence Ninth Heaven, summer pox print is on the face basic to disappear, and continue to use this invention anti-acne essence after two weeks, summer comedo on the face also disappears substantially, from after this three months, the summer did not all have long comedo on the face.
Wang, female, 25 years old, length has acne on the face, encounters and has pain, after acne disappear, can pockmark be left on the face, bring great misery to the life of Wang, smear this invention anti-acne essence upon somebody's introduction, smearing this invention anti-acne essence after one week, Wang's acne on the face disappear substantially, and pockmark is thin out, continue to use this invention anti-acne essence after one week, Wang's pox print on the face also disappears completely, and after this in three months, Wang does not recur acne on the face.
Zhang, man, 25 years old, length has large area pustule on the face, rack pustule and have pus outflow, after pustule disappears, also can leave pox print clearly, Zhang smears this invention anti-acne essence upon somebody's introduction, smearing this invention anti-acne essence after three weeks, Zhang's pustule is on the face desalinated substantially, continues to smear this invention anti-acne essence after one month, Zhang's pustule on the face disappears, and only leaves light pockmark.
Cloud, man, 23 years old, face is long pimple, and after smearing this invention anti-acne essence Ninth Heaven, cloud whelk disappears.
Thank certain, female, 28 years old, face is long a large amount of poxes, and skin is drier, smear this invention anti-acne essence after two weeks, the pox of thanking to certain face disappears substantially, continues to smear this invention anti-acne essence after one week, pox and the pox print of thanking to certain face all disappear, and the water profit that skin becomes, and glossy.
Lee, man, 29 years old, face is long acne, Lee's face is long has acne existing 6 years, and smearing this invention anti-acne essence after one month, Lee's acne are on the face desalinated substantially, continue to smear this invention anti-acne essence after one week, Lee's acne on the face disappear substantially, only leave light pox print.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; though but any change is done in its details, every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (10)
1. an anti-acne essence, is characterized in that: comprise following component: component A, B component, component C, D component, component E;
Described component A comprises following weight parts raw material: water 60-100 part, allantoin 0.6-2.4 part, polyglutamic acid 0.05-0.2 part;
Described B component comprises following weight parts raw material: propylene glycol 1-4 part, methyl hydroxybenzoate 0.1-0.3 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.2-0.8 part, water 8-12 part;
Described D component comprises following weight parts raw material: salicylic acid 0.5-2 part, propylene glycol 2-8 part;
Described component E comprises following weight parts raw material: matrine 0.25-1 part, Flos Chrysanthemi Indici extract 1-4 part, Bronopol 0.02-0.1 part.
2. anti-acne essence according to claim 1, is characterized in that: the weight portion of described each component is:
Described component A comprises following weight parts raw material: 80 parts, water, allantoin 1.2 parts, polyglutamic acid 0.1 part;
Described B component comprises following weight parts raw material: propylene glycol 2 parts, methyl hydroxybenzoate 0.2 part;
Described component C comprises following weight parts raw material: hydroxyethyl-cellulose 0.4 part, 10 parts, water;
Described D component comprises following weight parts raw material: salicylic acid 1 part, propylene glycol 4 parts;
Described component E comprises following weight parts raw material: matrine 0.5 part, Flos Chrysanthemi Indici extract 2 parts, Bronopol 0.05 part.
3. anti-acne essence according to claim 1, is characterized in that: described Flos Chrysanthemi Indici extract is one or more the mixture in Flos Chrysanthemi Indici lactone, bitter principle, chrysol, chrysanthone, northern Camphora, Chrysanthemin.
4. the preparation method of the anti-acne essence that one of claim 1-3 is described, is characterized in that: comprise the following steps:
(1) by admixed together for each for component A raw material, heat and stir, obtaining A phase;
(2) by admixed together for each for B component raw material, heat and stir, obtaining B phase, then B being added in A phase, stirring, obtain AB mixed phase;
(3) by admixed together for each for component C raw material, heat and stir, obtaining C phase, then C being added in AB mixed phase, stirring, obtain ABC mixed phase;
(4) by admixed together for each for D component raw material, stir, obtain D phase, then D is added in ABC mixed phase, stir, obtain ABCD mixed phase;
(5) component E joined in ABCD mixed phase, stir to obtain anti-acne essence.
5. the preparation method of anti-acne essence according to claim 4, is characterized in that; Under the condition of 80-85 DEG C, be stirred to each raw material dissolve admixed together for each for component A raw material completely in step (1).
6. the preparation method of anti-acne essence according to claim 4, is characterized in that: mixed by each for B component raw material in step (2) and under the condition of 65-75 DEG C, be stirred to each raw material dissolve completely.
7. the preparation method of anti-acne essence according to claim 4, is characterized in that: mixed by each for component C raw material in step (3) and under the condition of 55-65 DEG C, be stirred to each raw material dissolve completely.
8. the preparation method of anti-acne essence according to claim 4, is characterized in that: when the temperature of ABC mixed phase being down to 45-50 DEG C in step (4), then add D component.
9. the preparation method of anti-acne essence according to claim 4, is characterized in that: joined respectively in ABCD mixed phase by each raw material of component E in step (5).
10. the preparation method of anti-acne essence according to claim 4, is characterized in that: in step (5) after each raw material of component E adds, under the condition of 100-300r/min, stirs 15min, obtains anti-acne essence.
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| CN201510848480.1A CN105362143A (en) | 2015-11-26 | 2015-11-26 | Acne-removing essence and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389139A (en) * | 2016-11-22 | 2017-02-15 | 河南工业大学 | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof |
| CN108210407A (en) * | 2016-12-09 | 2018-06-29 | 景金发 | Natural anti-acne liquid |
| CN111588815A (en) * | 2020-05-29 | 2020-08-28 | 溯源生命科技股份有限公司 | Acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition |
| CN114868746A (en) * | 2022-04-01 | 2022-08-09 | 顺毅股份有限公司 | Bactericidal composition containing bronopol of alkaloid and alkaloid analogue |
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| CN101036645A (en) * | 2006-03-14 | 2007-09-19 | 张丽娟 | Pharmaceutical composition for treatment of acne |
| CN104434620A (en) * | 2014-10-13 | 2015-03-25 | 金日制药（中国）有限公司 | Acne-removing composition and preparation method thereof |
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| JPH1067673A (en) * | 1996-07-12 | 1998-03-10 | Lg Chem Ltd | Composition having activity suppressing action of 5 alpha-reductase and antibacterial action on propionibacterium acnes |
| CN101036645A (en) * | 2006-03-14 | 2007-09-19 | 张丽娟 | Pharmaceutical composition for treatment of acne |
| CN104434620A (en) * | 2014-10-13 | 2015-03-25 | 金日制药（中国）有限公司 | Acne-removing composition and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389139A (en) * | 2016-11-22 | 2017-02-15 | 河南工业大学 | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof |
| CN108210407A (en) * | 2016-12-09 | 2018-06-29 | 景金发 | Natural anti-acne liquid |
| CN111588815A (en) * | 2020-05-29 | 2020-08-28 | 溯源生命科技股份有限公司 | Acne-removing traditional Chinese medicine composition, application thereof and acne-removing balancing essence containing composition |
| CN114868746A (en) * | 2022-04-01 | 2022-08-09 | 顺毅股份有限公司 | Bactericidal composition containing bronopol of alkaloid and alkaloid analogue |
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