JP3014212B2 - Hair restoration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer excellent in hair growth and hair growth, hair loss prevention, dandruff prevention and the like.

[0002]

BACKGROUND OF THE INVENTION Alopecia is thought to be caused by various factors such as malnutrition due to inadequate blood circulation, decreased hair matrix activity, and imbalance of sex hormones. At present, it is not fully understood yet. Conventionally, hair restorations containing various agents have been used for prevention and treatment of hair loss, but no agent effective enough to suppress hair loss and promote hair growth and hair growth has yet been found.

[0003] Fuzi used as a raw material for the hair restorer of the present invention has been described in ancient times in China as a herbal sutra, and is known as an important crude drug widely used in various Chinese herbal prescriptions in Chinese herbal medicine, and it is known as Ranunculaceae. ) Of Aconitum species (Aconitum specie)
prepared from tuberous roots of s). Japanese Unexamined Patent Publication (Kokai) No. 3-271213 proposes a hair-growing and hair-restoring agent characterized by containing an extract of the root, stem or leaf of the aconite, which is the original plant, but using an extract of aconite alone The hair growth and hair growth effects were insufficient.

[0004]

SUMMARY OF THE INVENTION In view of the above circumstances, the present inventors have conducted intensive studies, and as a result, by blending an extract of Tsukushi with an amino acid or a derivative thereof, the safety of the mouse hair growth was high. The present invention has been found to show an excellent effect on the promotion of the growth of human hair and to show a remarkable effect on the anti-dandruff effect, thereby completing the present invention. That is, an object of the present invention is to provide a hair restorer having excellent effects such as hair growth, hair restoration, hair loss prevention, and dandruff prevention.

[0005]

SUMMARY OF THE INVENTION The present invention is a hair restorer comprising an extract of Fuzi and an amino acid or a derivative thereof.

The raw crude drug used in the hair restorer of the present invention is made of Aconitum species of the Ranunculaceae family.
Any root can be prepared as long as it is prepared from the root of the plant, and its origin and place of origin are not limited. In general, Aconitum plants contain highly toxic aconitine-based alkaloids, and since their use requires caution, they are more preferably referred to as processed sticks that have been prepared by detoxification such as heat treatment. It is better to use

[0007] As a base plant of Fuzi, for example, a cultivated species of Aconitum c.
armichaeli Debx), wild species (Aconitum kusnezoffii Rei) from various parts of China
chb. ), Such as Korean beetle (Acon)
itum triphyllum Nakai, Aconitum coreanum
Rap. ), Japanese Aconitum beetle (Aconitu)
m japonicum Thumb. ), Aconitum beetle (Aconitum chinense Pax)
t. ). In particular, Chinese beetle from Sichuan, China is preferable in terms of quality stability and supply with a certain cultivation method.

[0008] As a detoxification processing method, Japanese Patent Publication No. 37
No. -18498, tuber root is autoclaved at 100-130 ° C., pressure 1.0-1.5 kg / c.
The method of preparing by pressurizing and heat-treating m2 for 20 to 40 minutes is a particularly preferable method because a simple, effective and safe crude drug can be stably produced. As an example prepared by this method, the product name of “Non-Japanese Pharmacopoeia”
Is mentioned. In addition, as a method mainly used in China, a method of immersing the washed tubers in bitter solution for several days and drying them, or a method of preparing by drying after repeating the treatment such as steaming and boiling, or drying. For example, there is a method in which the material is washed with water, divided vertically, buried in ash at the time of freshness, heated, pressurized, etc. and dried to prepare. As an example of the preparation by this method, the one sold in the market in Sichuan, China as a sticky ball (referred to as a gun stick in Japan) is preferable because it is sufficiently detoxified with a certain quality.

[0009] The extract of the seaweed of the present invention, when the seaweed is extracted with a solvent, migrates from the seaweed to the solvent, and refers to the component. This extract is used in a dry state after the solvent is removed. It can also be used after being dissolved in a solvent. In the latter case, the extraction solvent constitutes a part of the base in the hair restoration of the present invention.

Solvents include water, alcohols such as methanol, ethanol, butanol ethers such as diethyl ether, dioxane, ketones such as acetone, aliphatic hydrocarbons such as pentane and hexane.
Cyclohexane, esters, such as ethyl acetate, can be used. When the extract is used as a dried product after removing the solvent, any of the above-mentioned solvents can be used alone or in combination. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

At the time of extraction, the sticks can be used as they are, or they can be crushed or pulverized to improve contact with a solvent. The ratio between the attachment and the solvent is not particularly limited, but from the viewpoint of extraction efficiency and convenience, the attachment 1
It is preferred to use 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time varies depending on the extraction temperature, the presence or absence of stirring, and the like, but is preferably in the range of 30 minutes to 2 weeks.

On the other hand, the amino acids or derivatives thereof used in the hair restorer of the present invention include, for example, L-methionine and L-cystine which are said to be involved in protein synthesis of hair and the like, and N-acetyl-L-methionine which is a derivative thereof, Isopropyl-L-methionine, L-cystine hydrochloride and the like. L-serine, L-threonine, L-aspartic acid and its sodium salt, L-lysine and its hydrochloride, L-arginine and its hydrochloride, which are useful nutritional supplements in the functional metabolism of the skin. Can be Furthermore, NMF (n
aturalmoisturizing facto
Amino acids such as glycine, alanine, phenylalanine, valine, leucine, tyrosine, arginine, histidine, ornithine, proline, glutamic acid, and citrulline as the r) component are also applied.

The present inventor has conducted intensive studies on the above-mentioned constituents to be incorporated into the hair restorer. As a result, the hair restorer prepared by combining the extract of the Fusatsu of the present invention with an amino acid or a derivative thereof has a synergistic effect. Excellent hair growth effect,
It has been found that it has effects such as a hair growth effect, a hair loss prevention effect, and an anti-dandruff effect.

The mixing ratio of the extract of Fuzi and the amino acid or a derivative thereof according to the present invention is appropriately selected depending on the dosage form of the hair restorer, etc., and the extract of the Fuzi extract is based on the total amount of the hair restorer. Is 0.0001 to 20.0 wt%
(Equivalent to dry matter), 0.01 to 5.0 wt% of amino acids
% Below the lower limit of each compounding amount is not sufficient for the intended effect of the present invention. On the other hand, even if it exceeds the upper limit, improvement of the effect corresponding to the increase cannot be expected.

The hair restorer of the present invention can be made into a dosage form such as a hair tonic, a hair lotion, a hair cream, a shampoo, a rinse, a hair foam, a hair gel, etc. according to a conventional method.

The hair restorer of the present invention includes pigments, fragrances, preservatives, keratolytic agents, anti-inflammatory agents, anti-androgens, hair restorers, vitamins, antioxidants, fresheners, and other crude drug extracts. It can be appropriately compounded within a range that achieves the object of the invention.

[0017]

The present invention will be described below in detail based on examples and comparative examples. The mouse hair growth promotion effect test method, the human hair growth promotion effect test method, and the practical test method described in the Examples are shown below.

(1) Mouse hair growth promoting effect test The hair at the center of the back of a C3H mouse (male, 7 weeks old) was shaved with a clipper and a shaver, and the sample was placed on the shaved site once a day, per mouse. 0.2 ml was applied. A group of 10 animals was used for one sample. On the 15th day after the start of the experiment, a photograph of the back of the mouse was taken, the shaved area and the hair growth area were calculated, the hair growth rate (%) was determined, and the hair growth promoting effect was determined by the average value of 10 cases.

(2) Test Method for Promoting Human Hair Growth The hair of a subject, who is a male pattern baldness, at a position 5 cm above the ears of the heads of the 10 test subjects was formed into a circular shape having a diameter of 1 cm at two places on the left and right. About 3 ml of the sample of the example or the comparative example was applied to the shaved test site on the left side twice daily in the morning and evening, and compared with the untreated right side. The effect was determined on the 28th day after the start of the test.
Twenty hairs on each of the left and right test sites were shaved, and the average value (B) of the lengths of the 20 hairs on the left side (to which the example or the comparative example was applied) was calculated as the length of the 20 right hairs (untreated). The value divided by the average value (A) of the height was obtained and evaluated. The judgment results were shown as the average of (B) / (A) of 10 test subjects.

(3) Practical Test Method The effect of applying the sample to the heads of 20 test subjects who are male pattern baldness patients twice daily in the morning and evening for 6 consecutive months was evaluated. The test results showed that for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect, "hair was bristle or hair was increased", "hair loss was reduced", and "hair loss was reduced" And the number of respondents.

Preparation Example 1 (Preparation of Bushi Extract) (1) A crushed dried tuber of Bushi (produced as Kawa Ozu or Hoshibushi) from Shikoku, China, is autoclaved at 100-130 ° C. Adjusted to 1-1.5 kg / cm2,
Pressurize and heat for 40 minutes. Processed attachment 100
g in 1500 ml of 70 v / v% ethanol (hereinafter referred to as v
/ V% is abbreviated to%) at room temperature (20 to 25 ° C) for 16 hours, and the supernatant is collected by filtration, concentrated at 45 ° C under reduced pressure for 3 hours, and the solvent is distilled off. To obtain a brown extract.
7 g were obtained.

(2) 100 g of Fuchu produced in Sichuan, China, which was processed in the same manner as in Production Example 1 (1), was immersed in 1500 ml of 40% ethanol at room temperature (20 to 25 ° C.) for 16 hours.
The supernatant was collected by filtration, concentrated at 45 ° C. under reduced pressure for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

(3) 50 g of a gun stick (commercially available as a stick valve) from Sichuan, China is immersed in 500 ml of 70% ethanol at room temperature (20 to 25 ° C.) for 16 hours, and the supernatant is filtered. The extract was concentrated at 45 ° C. under reduced pressure for 2 hours, and after evaporating the solvent, 5.3 g of a brown extract was obtained.

(4) Non-Japanese Pharmacopoeia standard processed bush powder 50
g in 500 ml of 40% ethanol at room temperature (20 to 2).
(5 ° C.) for 10 hours, and the supernatant was collected by filtration, concentrated at 45 ° C. under reduced pressure for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

Examples 1 to 12 and Comparative Examples 1 to 12 (Heart Tonic) Each of the hair tonics prepared by blending the extract of the abacillus prepared in Production Example 1 with an amino acid or a derivative thereof in the following component composition: Was prepared and the above-described tests were performed.

(1) Composition Ingredient Ingredient (wt%) Ethanol 60.0 Extract of Fuzi, Amino acids Tables 1 and 2 Propylene glycol 1.0 Perfume 0.1 Purified water Remaining amount when total amount is 100.0 ───────────── ──────────────────────

(2) Preparation method The extract or flavor of azuki bean, an acyl or ester derivative such as N-acetyl-L-methionine or isopropyl-L-methionine in ethanol, and other amino acids are
That is, L-methionine, L-serine, L-threonine, L-cystine and its hydrochloride, L-lysine and its hydrochloride, L-arginine and its hydrochloride, L-aspartic acid and its sodium salt are propylene glycol. And dissolved in purified water, and each solution was uniformly mixed with stirring to prepare each hair tonic.

(3) Characteristics As shown in Tables 1 and 2, the results of the various tests of each hair tonic are shown in Tables 1 and 2 for Comparative Examples 1 to 4 and the amino acids or derivatives thereof, each of which is a mixture of the extract of the Fusatsu of the present invention. In Comparative Examples 5 to 12, which were used alone or in combination, the hair growth promoting effect was low, and no hair growth and dandruff preventing effects were observed. On the other hand, the hair restorer of the present invention of Examples 1 to 12 in which the extract of the seaweed of the present invention and the amino acid were simultaneously mixed exhibited a high hair growth promoting effect in mice and humans, and the results of practical tests were also good. Results were shown. In Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0029]

[Table 1]

[0030]

[Table 2]

[0031]

As described above, it is apparent that the present invention provides a hair restorer which exhibits a remarkable hair growth promoting effect and is excellent in hair growth effect, hair loss prevention and dandruff prevention effects.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K 7/06

Claims (2)

(57) [Claims] 1. A hair restorer comprising an extract of Fuzi and an amino acid or a derivative thereof. 2. The method according to claim 2, wherein the amino acid or a derivative thereof is L
-Methionine, N-acetyl-L-methionine, isopropyl-L-methionine, L-cystine and its hydrochloride, L-serine, L-threonine, L-aspartic acid and its sodium salt, L-lysine and its hydrochloride, L
The hair restorer according to claim 1, which is at least one selected from the group consisting of arginine and a hydrochloride thereof.