JPS6322507A - External preparation for skin - Google Patents

Abstract

PURPOSE:An external preparation for skin especially effective for preventing, remedying and treating pimples, effectively preventing dandruff by using it on the scalp, obtained by blending an antimicrobial agent and/or keratin releasing agent with herbaceous peony, peony and/or an extract thereof. CONSTITUTION:(A) One or more selected from herbaceous peony, peony and an extract thereof and (B) and antimicrobial agent such as sulfur, hinokitiol, KANKOSO 201, berberine, etc., and/or (C) a keratin releasing agent such as salicylic acid, resorcin, etc., as active ingredients are blended to give an external preparation for skin penetrating to the skin extremely well, providing neither irritation nor hormone-like side effects at all and especially effective for preventing, remedying and treating pimples and effective for preventing dandruff. The amount of the component A is >=about 0.005wt% in case of powder or essence - preferably to about 10wt% calculated as dried residue based on the total amounts of the composition, the amount of the component B is 0.001-10wt% and the amount of the component C is about 0.01-20wt%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation for skin. More specifically, one or more selected from the group consisting of peonies, botanpi and extracts thereof, sulfur, hinokitiol,
Antibacterial agents such as Photosensor No. 201 and thioxolone and/or
It also relates to external skin preparations that are characterized by containing exfoliating agents such as salicylic acid and resorcinol, and are particularly effective in preventing, treating, and treating acne, and can also be used on the scalp to effectively prevent dandruff. can do.

[Prior art] Acne is a skin disease that mainly occurs during adolescence and is called pre-vulgaris, which is clinically defined as ``chronic inflammatory changes that occur in the upper foramen, mainly in the pilosebaceous system.'' has been done.

The etiology of acne is still unclear, and although it is a skin disease in which various factors are intricately intertwined, in general,
Excessive sebum secretion, hair follicle keratinization, and microorganisms within the hair follicle are thought to play important roles.

Therefore, as external preparations for treating acne, creams and ointments containing sebum secretion inhibitors, exfoliating agents, and antibacterial agents are commonly used in response to various factors. However, existing acne treatment agents containing various drugs have various drawbacks. For example, ethinyl estradiol, a sebum secretion inhibitor, inhibits epidermal growth and reduces sebaceous gland secretion, but the side effects caused by hormones are not desirable for adolescent boys and girls. In addition, antibacterial agents such as sulfur, hinokitiol, photosensor No. 201, and berberine are effective against Propionibacterium acnes, a acne bacterium resident on the skin.
Even if they exhibit extremely high antibacterial activity against acne (acne) in vitro, in most cases they do not exhibit the expected therapeutic effect when incorporated into creams and ointments and used to treat acne.

[Problems to be Solved by the Invention] The present inventors have proposed that the effects of conventional antibacterial agents or exfoliating agents be increased on the skin, and that they are particularly effective in preventing, treating, and treating acne. While researching compounds that can be used to effectively prevent dandruff, we discovered that the herbal medicines peony, botanpi, or their extracts, and antibacterial agents such as sulfur, hinokitiol, photosensor No. 201, and berberine, etc. Alternatively, the present invention was completed based on the discovery that an external skin preparation containing a keratin exfoliant such as salicylic acid or resorcinol can achieve this purpose.

[Means for Solving the Problems] That is, the present invention provides one or more species selected from the group consisting of peonies, botanpi, and extracts thereof;
This external skin preparation is characterized by containing an antibacterial agent and/or a keratin exfoliant. Such external skin preparations are particularly effective in preventing, treating, and treating acne, and can also be used on the scalp to effectively prevent dandruff.The structure of the present invention will be described in detail below.

In the present invention, one or more selected from the group consisting of peonies, botanpis, and extracts thereof are used. Peonies are members of the Paeonaceae family.
1aceae) Peony root, also known as peony root, is the dried root bark of peony, which also belongs to the peony family. The extract of Peony or Botanpi is obtained by extracting the roots of the above-mentioned Peony or Botanpi with water or an aqueous alcohol, such as ethanol, usually at 15 to 25°C. The blending amount is approximately 0.005% (wt%) in the entire composition, including the extract (residue after distilling off the extraction solvent).
) or more. The upper limit of the amount to be blended is not particularly limited, but from the viewpoint of commercial value such as coloring, it is preferable to blend up to about 10% in total as a dry residue.

On the other hand, specific antibacterial agents that can be incorporated in the present invention are as follows.

Sulfur, hinokitiol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, chlorhexidine cluconsanate, helocarban, chlorophenesin,
Benzethonium chloride, benzalkonium chloride, lysozyme chloride, alkyldiaminoethylglycine hydrochloride, isopropylmethylphenol, benzoic acid, photosensitive element No. 201,
Dimol, hexachlorophene, berberine, thioxolone and their derivatives.

The blending amount is 0.001% or more and 10% or less, preferably 0.01% or more and 5% or less.

Further, as the exfoliating agent that can be used in the present invention, specifically, the following exfoliants are used.

Sulfur, salicylic acid, resorcinol, thioxolone, dibenzothiophene and their derivatives.

In the present invention, any one or more selected from the group consisting of these antibacterial agents and exfoliating agents may be used.

The blending amount is approximately 0.01% or more and 20% or less.

The skin external preparation of the present invention contains peonies, botanpi and their extracts, antibacterial agents or exfoliating agents, as well as drugs such as zinc and its compounds, lactic acid, and although it varies depending on the dosage form, oil, Surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, and the like can be appropriately added within ranges that do not impair the effects of the present invention.

The external preparation for skin of the present invention may be in any form as long as it can be applied to the skin, such as cream, ointment, lotion, or tonic.

[Effects of the invention] A skin preparation for external use containing one or more of peonies, botanpi and their extracts and an antibacterial agent or exfoliating agent penetrates into the skin very well and causes no irritation or hormonal side effects. In particular, it works effectively in the prevention, treatment, and treatment of acne, and can also be used on the scalp to effectively prevent dandruff.

[Example Example 1 Lotion Sorbitol (70%) 3.0g Glycerin 5.0g Berberine
0.02g water
70.8g Mix and dissolve these ingredients, add allantoin 0.1g peony extract 0.5g buttonpi powder
0.08g polyoxyethylene hydrogenated castor oil derivative 0.5g ethanol 20.0g fragrance
Add an appropriate amount of the mixed solution while stirring to obtain a lotion as a homogeneous solution.

Example 2 Cream beeswax 10. og paraffin wax 6.0g lanolin
3.0g isopropyl myristate 6.0g squalane
8.0g liquid paraffin 25.0
g Peony extract 0.1g sulfur 2. Og polyoxyethylene solpicone mononutheary)
1. 8g sorbitan monostearate 4
．． 2g preservative Mix appropriate amount of these ingredients, heat at about 75℃ to dissolve, and add to this at about 75℃
Propylene glycol heated with 2. Og borax
0.7g water
Add 31.2g of the mixture while stirring, cool, add an appropriate amount of fragrance at 55°C,
Continue stirring until 5°C and leave to obtain cream.

Example 3 Hair tonic ethanol 55.0g Seven plated thiol 0.5g Nikkor HCO
-60 1.0g fragrance
An appropriate amount was dissolved at room temperature to obtain an alcohol phase.

Peony extract 0.5g purified water
42.0g glycerin
1.0g dye
An appropriate amount of the mixture was dissolved under heating and cooled to obtain an aqueous phase.

The alcohol phase was added to the aqueous phase and solubilized to obtain a hair tonic.

Example 4 Ointment solid paraffin 10.0g peace wax 10.0g squalane
10.0g Peony extract
1.0g sulfur
2.0g fragrance Appropriate amount Vaseline 67.0g The above ingredients were mixed, and the mixture was heated and dissolved at 80°C, and then cooled with stirring to obtain an ointment.

The effects of the present invention will be explained in detail by briefly giving clinical examples.

(Medicine used) A lotion-type skin external preparation obtained by the following formulation and manufacturing method was used.

Peony extract 0.5gP,
O, E, (60 mon) hydrogenated castor oil 2.0g
Glycerin 10. og dipropylene glycol 10. Ogl, 3-butylene glycol 5.0g polyethylene glycol 15
00 Heat and melt 5.0g or more at 60°C. Add to this Photosensor No. 201 0.5g cetyl isooctanate 10.0g squalane
5. og methylparaben
1.3g! Add and mix the same mixture heated and dissolved at <60'C, and process with a homomixer to make a gel.

Next, 0.3 g of carboxyvinyl polymer and 0.08 g of sodium hexametaphosphate dissolved in 11.0 g of ion-exchanged water were slowly added to this gel and dispersed with a homomixer, and then 0.12 g of potassium hydroxide was added to the ion-exchanged water. A solution dissolved in 39.2 g of exchanged water was added and mixed, and emulsified with a homomixer to obtain a lotion-type skin preparation for external use.

As a control drug, an external preparation containing only peony extract or only Photosensor No. 201 was used, and correction was made with ion-exchanged water.

Case No. 1 to 10 Case N containing only Photosensor No. 201
o, 11-20 Contains only peony extract Case No. 21-30 Photosensor No. 201 10 Contains peony extract or more A total of 30 men and women were allowed to use the product for about 1 month.

(How to use) After thoroughly washing your face with cosmetic soap, apply the above-mentioned lotion-type skin preparation once a day only on the branch area.
It was applied ~3 times.

(Observation items and observation points) Observe the three symptoms of vomiting, papules, and vomiting, and synthesize the severity of the individual findings to determine the severity of vulgaris.
The symptoms were divided into three stages: moderate and mild. Follow-up is before treatment,
The test was conducted 1 week, 2 weeks, 3 weeks, and 4 weeks after the treatment.

(Overall improvement level) Compared to before use, the degree of improvement in symptoms due to the drug used, markedly relieved (1+)), considerably relieved (Ti), somewhat relieved (+)
It was divided into 5 stages: no change (±), and worsening (-).

(Usefulness) Based on the overall improvement level, it was judged as extremely useful (1+), quite useful (++), somewhat useful (+), and ineffective (±).

(Results) The clinical test results for a total of 30 people, 8 men and 22 women, showed that out of 10 people who used only the external preparation containing Kosensen No. 201, 3 people said + (somewhat useful) (30χ), and 7 people said ± (ineffective). (70%), 10 out of 10 people using external preparations containing only peony extract (slightly useful)
3 people (30%) said ± (ineffective), 7 people (70χ) said that it was +4+ (extremely useful), 3 people (30%) said +4+ (extremely useful), and 3 people (30%) said +4+ (extremely useful). 4 people (40%) said it was useful), and 3 people said it was + (somewhat useful).
0%), demonstrating the effectiveness of the present invention in treating acne.

Claims (1)

[Claims] 1. A skin preparation for external use, comprising one or more selected from the group consisting of peonies, botanpis, and extracts thereof, and an antibacterial agent and/or a keratin exfoliant.