JPS6360935A - Sebum suppressive agent - Google Patents
Sebum suppressive agentInfo
- Publication number
- JPS6360935A JPS6360935A JP61205633A JP20563386A JPS6360935A JP S6360935 A JPS6360935 A JP S6360935A JP 61205633 A JP61205633 A JP 61205633A JP 20563386 A JP20563386 A JP 20563386A JP S6360935 A JPS6360935 A JP S6360935A
- Authority
- JP
- Japan
- Prior art keywords
- sebum
- peony
- suppressive agent
- extract
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002374 sebum Anatomy 0.000 title claims abstract description 22
- 239000004480 active ingredient Substances 0.000 claims description 4
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 claims 1
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 claims 1
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 claims 1
- 241000736199 Paeonia Species 0.000 abstract description 15
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 210000000056 organ Anatomy 0.000 abstract description 4
- 230000028327 secretion Effects 0.000 abstract description 4
- 206010000496 acne Diseases 0.000 abstract description 3
- 241001106477 Paeoniaceae Species 0.000 abstract description 2
- 206010039792 Seborrhoea Diseases 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 230000002441 reversible effect Effects 0.000 abstract description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract description 2
- 230000001629 suppression Effects 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- -1 ethanol Chemical compound 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000010227 cup method (microbiological evaluation) Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
[産業上の利用分野]
本発明は皮脂抑制剤に関する。 更に詳しくは、本発明
は、シャクヤクまたはその抽出物を有効成分として配合
することを特徴とする外用剤に関するもので、皮脂の分
泌過剰によっておこるにきび等の脂漏性疾患で温和な効
果を示す皮膚疾患治療剤である。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a sebum suppressant. More specifically, the present invention relates to a topical preparation that is characterized by containing peony or its extract as an active ingredient, and which has a mild effect on the skin for seborrheic diseases such as acne caused by excessive secretion of sebum. It is a disease treatment agent.
[従来の技術]
今日まで特異的に皮脂分泌抑制を示し、それら以外の器
官に影響しないような化合物は知られていない。経口投
与用に皮脂抑制剤シブロチロンアセテートがある。経口
投与は局所施用よりも副作用が大きいことが多い。その
抗アンドロゲン性のために、シブロチロンアセテートは
女性にのみしか用いることができない。[Prior Art] To date, no compound has been known that specifically inhibits sebum secretion and does not affect other organs. The sebum suppressant sibrothyrone acetate is available for oral administration. Oral administration often has greater side effects than topical application. Due to its anti-androgenic properties, sibrothyrone acetate can only be used by women.
[発明が解決しようとする問題点]
本発明者らは、特異的に皮脂分泌抑制を示し、それら以
外の器官に影響しないような化合物を研究していたとこ
ろ、シャクヤクまたはその抽出物を有効成分として配合
することを特徴とする外用剤が、この目的を達成できる
ことを見いだして、本発明を完成した。[Problems to be Solved by the Invention] The present inventors were researching compounds that specifically inhibit sebum secretion and do not affect other organs, and found that peony or its extract was used as an active ingredient. The present invention was completed by discovering that an external preparation characterized by being formulated as a compound can achieve this purpose.
[問題点を解決するための手段]
すなわち本発明によるシャクヤクまたはその抽出物を有
効成分として配合することを特徴とする外用剤は皮脂を
抑制する重要な治療剤である。[Means for Solving the Problems] That is, the external preparation according to the present invention, which is characterized by containing peony or its extract as an active ingredient, is an important therapeutic agent for suppressing sebum production.
以下本発明の構成について詳述する。The configuration of the present invention will be explained in detail below.
本発明に用いられるシャクヤクは、ボタン科(Paeo
(+ 1aceae)シャクヤクの根部であり、一般的
には乾燥したものを用いる。The peonies used in the present invention are of the Paeoniaceae family (Paeo family).
(+ 1aceae) The root of a peony, and is generally used dried.
本発明においてはシャクヤク末または水もしくは水性ア
ルコール、たとえばエタノール、あるいはそれらの混合
物を用い、通常15〜25℃で抽比処理して得られるエ
キス(抽出溶媒を留去した残分)として全組成中に概ね
0.005%(重量%)以上配合する。配合量の上限は
特に限定するものではないが着色等の商品価値の観点か
らシャクヤクおよびその抽出物の配合量は、乾燥残部と
して合計で約10%まで配合するのが好ましい。In the present invention, the entire composition is extracted as an extract (residue after distilling off the extraction solvent) obtained by drawing with peony powder, water, aqueous alcohol, such as ethanol, or a mixture thereof, usually at 15 to 25°C. Approximately 0.005% (wt%) or more is added to. Although the upper limit of the blending amount is not particularly limited, from the viewpoint of commercial value such as coloring, it is preferable that the blending amount of peony and its extract is up to about 10% in total as the dry residue.
本発明の皮脂抑制剤には、シャクヤクエキスのほかにヘ
キサクロロフェン、フェノールおよびトリクロロカルバ
ニリド等の抗菌剤、感光素、サリチル酸、亜鉛およびそ
の化合物、乳酸、ビタミンB2.86等の薬剤や角質剥
離剤、および性状によっても異なるが、油分、界面活性
剤、水、エタノール、保湿剤、増粘剤、香料、色素等を
本発明の効果を損なわない範囲で適宜配合することがで
きる。In addition to peony extract, the sebum suppressant of the present invention includes antibacterial agents such as hexachlorophene, phenol, and trichlorocarbanilide, photosensitizers, salicylic acid, zinc and its compounds, lactic acid, drugs such as vitamin B2.86, and exfoliating agents. Oils, surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, and the like can be suitably blended within the range that does not impair the effects of the present invention, although they vary depending on the agent and properties.
本発明の皮脂抑制剤の性状は、クリーム、軟膏、ローシ
ョン、等外皮に適用できる性状のものであればいずれで
も良い。The sebum suppressant of the present invention may be in any form as long as it can be applied to the skin, such as a cream, ointment, or lotion.
[発明の効果]
本発明のシャクヤクエキスは非常に良好な可逆的局所皮
脂の抑制を示す。またこの化合物は非常に良く皮膚に浸
透し、全く刺激を与えないので、特ににきびおよび脂漏
の治療に適する。この活性は特異的に皮脂に向けられ、
それら以外の器官に全く影響しない。[Effects of the Invention] The peony extract of the present invention exhibits very good reversible local sebum suppression. The compound also penetrates the skin very well and is completely non-irritating, making it particularly suitable for the treatment of acne and seborrhea. This activity is specifically directed towards sebum,
It has no effect on any other organs.
[実施例コ
実施例1 化粧水
ソルビトール(70%) 3.0gグリセリ
ン 5.0g水
70.0gこれらの成分を
混合溶解し、これに、
シャクヤクエキス 1.5gポリオキ
シエチレン硬化ヒマシ油誘導体0.5g
エタノール 20.0g香料
適量の混合溶液を攪拌しなが
ら加えて均一な溶液として化粧水を得る。[Example Example 1 Lotion Sorbitol (70%) 3.0g Glycerin 5.0g Water
70.0g Mix and dissolve these ingredients, add 1.5g peony extract 0.5g polyoxyethylene hydrogenated castor oil derivative 20.0g ethanol 20.0g fragrance
Add an appropriate amount of the mixed solution while stirring to obtain a lotion as a homogeneous solution.
実施例2 クリーム
ミツロウ 11.0gパラフィ
ンワックス 6.0gラノリン
3.0gイソプロピルミリステート
6.0gスクワラン
8.0g流動パラフィン 27.5g
シャクヤクエキス 1.5gインドメ
タシン 0.5gポリオキシエチレジ
ンルピクンモノステアレー)
1. 5gソルビタンモノステアレート 4.0
g防腐剤 適量この成分を混
合し、約75℃で加熱し溶解し、これに約75℃で、加
熱した、
プロピレングリコール 2.Ogホウ砂
1.0g水
28.0gの混合液を
攪拌しながら加え、冷却し、55℃で香t1を適量加え
、45℃まで攪拌をつづけ、放置してクリームを得る。Example 2 Cream beeswax 11.0g paraffin wax 6.0g lanolin
3.0g isopropyl myristate
6.0g squalane
8.0g liquid paraffin 27.5g
Peony extract 1.5g Indomethacin 0.5g Polyoxyethyresine lupicum monostearate)
1. 5g sorbitan monostearate 4.0
g Preservative Mix appropriate amounts of these ingredients, heat at about 75°C to dissolve, and then heat to about 75°C, propylene glycol 2. Og borax
1.0g water
Add 28.0 g of the mixture while stirring, cool, add an appropriate amount of incense t1 at 55°C, continue stirring until 45°C, and leave to obtain cream.
実施例3 軟膏
固体パラフィン 10.0gピースワ
ックス 10.ogスクワラン
10.0gシャクヤクエキス
1.0gレゾルシン
0.1g亜鉛華 0.5
g香料 適量ワセリン
68.4g上記成分を混合し、混
合物を80℃に加熱溶解した後、攪拌冷却を行い、軟膏
を得た。Example 3 Ointment solid paraffin 10.0g peace wax 10. og squalane
10.0g Peony extract
1.0g resorcinol
0.1g zinc white 0.5
gFragrance Appropriate amount of Vaseline
68.4 g of the above components were mixed, the mixture was heated and dissolved at 80° C., and then cooled with stirring to obtain an ointment.
次に臨床例をあげて本発明の効果を更に詳細に説明する
。Next, the effects of the present invention will be explained in more detail by giving clinical examples.
(使用薬剤)
下記処方、製造法で得たローションタイプの皮膚外用剤
を使用した。(Medicine used) A lotion-type skin external preparation obtained by the following formulation and manufacturing method was used.
シャクヤクエキス 1.0gP、O
,E、(60モル)硬化ヒマシ油 2.0gグリセ
リン 10.0gジプロピレング
リコール 10.0g1.3−ブチレングリ
コール 5.0gポリエチレングリコール15
00 5.0g以上を60’Cで加熱溶解する。こ
れにセチルイソオクタネート 10.0gス
クワラン 5.0gメ・チル
パラベン 1.0gを同じ<60
’Cに加熱溶解したものを添加混合し、ホモミキサーで
処理をしてゲルを作る。Peony extract 1.0gP, O
, E, (60 mol) Hydrogenated castor oil 2.0 g Glycerin 10.0 g Dipropylene glycol 10.0 g 1.3-Butylene glycol 5.0 g Polyethylene glycol 15
00 5.0g or more is heated and melted at 60'C. To this, add 10.0 g of cetyl isooctanate, 5.0 g of squalane, and 1.0 g of methylparaben at the same <60
Add and mix the solution heated and dissolved in 'C, and process with a homomixer to make a gel.
次にこのゲルに
カルボキシビニルポリマー 0.3gへキサ
メタリン酸ソーダ 0.08gを、
イオン交換水 11.0gに溶解
せしめたものを徐添加しホモミキサーで分散した後、
水酸化カリウム 0.12gを
イオン交換水 39.5gに溶解し
たものを添加混合し、ホモミキサーで乳化してローショ
ンタイプの皮In外用剤を得た。Next, 0.3 g of carboxyvinyl polymer and 0.08 g of sodium hexametaphosphate dissolved in 11.0 g of ion-exchanged water were slowly added to this gel and dispersed with a homomixer, and then 0.12 g of potassium hydroxide was added to the ion-exchanged water. A solution dissolved in 39.5 g of exchanged water was added and mixed, and the mixture was emulsified using a homomixer to obtain a lotion-type skin In external preparation.
(使用対象および観察期間)
15〜30歳までの尋常性座癒患者男女計20名に4週
間使用させた。(Targets for Use and Observation Period) A total of 20 male and female patients with sitting vulgaris aged 15 to 30 years were allowed to use the product for 4 weeks.
(使用方法)
化粧石鹸を用いて顔面をよく洗浄した後、支庁の上にの
み、前記したローションタイプの皮膚外用剤を1日に1
〜3回塗布せしめた。(How to use) After thoroughly washing your face with cosmetic soap, apply the above-mentioned lotion-type skin preparation once a day only on the branch area.
It was applied ~3 times.
(皮脂の測定)
使用前と4週間使用後の総皮脂量をガラスカップ法で皮
脂を採取して重量法[Ohokawa、H,、et a
l、、Anal、Biochem、、95.35135
8(1979)]にて劃定した。皮脂量は以下の式のご
とく相対比で表した。(Measurement of sebum) The total amount of sebum before use and after 4 weeks of use was measured by collecting sebum using the glass cup method and using the gravimetric method [Ohokawa, H., et al.
l,,Anal,Biochem,,95.35135
8 (1979)]. The amount of sebum was expressed as a relative ratio as shown in the following formula.
(以下余白)
(結果)
男6名、女14名計20名の臨床テスト結果、平均皮脂
減少率は、8.5%であり、本発明の皮脂抑制剤の効果
が立証された。(Margins below) (Results) The results of a clinical test conducted on a total of 20 people, 6 men and 14 women, showed that the average sebum reduction rate was 8.5%, proving the effectiveness of the sebum suppressant of the present invention.
Claims (1)
ことを特徴とする皮脂抑制剤。A sebum suppressant characterized by containing Chinese cabbage or an extract thereof as an active ingredient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61205633A JPH0669955B2 (en) | 1986-09-01 | 1986-09-01 | External preparation for sebum control |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61205633A JPH0669955B2 (en) | 1986-09-01 | 1986-09-01 | External preparation for sebum control |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6360935A true JPS6360935A (en) | 1988-03-17 |
JPH0669955B2 JPH0669955B2 (en) | 1994-09-07 |
Family
ID=16510120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61205633A Expired - Lifetime JPH0669955B2 (en) | 1986-09-01 | 1986-09-01 | External preparation for sebum control |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0669955B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1112122A (en) * | 1997-06-20 | 1999-01-19 | Pola Chem Ind Inc | Skin-improving cosmetic |
AT505539B1 (en) * | 2007-09-03 | 2009-02-15 | Peter Dr Laszloffy | EXTRACTION PROCESS FOR THE PREPARATION OF A HERB EXTRACT AND A COSMETIC CARE OINTMENT |
CN109771345A (en) * | 2019-02-28 | 2019-05-21 | 北昊干细胞与再生医学研究院有限公司 | Oil-control cosmetic composite and its application |
-
1986
- 1986-09-01 JP JP61205633A patent/JPH0669955B2/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1112122A (en) * | 1997-06-20 | 1999-01-19 | Pola Chem Ind Inc | Skin-improving cosmetic |
AT505539B1 (en) * | 2007-09-03 | 2009-02-15 | Peter Dr Laszloffy | EXTRACTION PROCESS FOR THE PREPARATION OF A HERB EXTRACT AND A COSMETIC CARE OINTMENT |
CN109771345A (en) * | 2019-02-28 | 2019-05-21 | 北昊干细胞与再生医学研究院有限公司 | Oil-control cosmetic composite and its application |
Also Published As
Publication number | Publication date |
---|---|
JPH0669955B2 (en) | 1994-09-07 |
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