JPS6322506A - External preparation for skin - Google Patents

Abstract

PURPOSE:An external preparation for skin especially effective for preventing, remedying and treating pimples, effectively preventing dandruff by using it on the scalp, obtained by blending an anti-inflammatory drug with herbaceous peony, peony or an extract thereof. CONSTITUTION:(B) One or more selected from herbaceous peony, peony and an extract thereof and (B) one or more anti-inflammatory drugs selected from glycyrrhizic acid, allantoin, indomethacin and an derivative thereof as active ingredients are blended to give an external preparation for skin having improved mildly suppressing effects on inflammation, penetrating to the skin extremely well, providing neither irritation nor hormone-like side effects at all and especially effective for preventing, remedying and treating pimples and effective for preventing dandruff. The amount of the component A is >=about 0.005wt% in case of powder or essence - preferably to about 10wt% calculated as dried residue based on the total amounts of the composition and the amount of the component B is 0.001-20wt% preferably 0.01-10wt%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation for skin. More specifically, one or more selected from the group consisting of peonies, botanpi, and extracts thereof, and one or more anti-inflammatory agents such as glycyrrhizic acid, allantoin, indomethacin, and derivatives thereof. It relates to a skin external preparation characterized by a combination of two or more types, and is particularly effective in preventing, treating, and treating acne, and can also be used on the scalp to effectively prevent dandruff.

[Conventional technology 1 Acne is a skin disease that mainly occurs during adolescence and is called stratification vulgaris, which is clinically defined as ``chronic inflammatory changes that occur in the upper foramen, mainly in the pilosebaceous system.''It's broken.

The etiology of acne is currently not clear, and it is a skin disease in which various factors are intricately intertwined, but it is generally believed that excessive sebum secretion, hair follicle keratinization, and bacteria within the hair follicle play important roles. There is.

Acne occurs due to the above-mentioned factors, and as the lesion progresses, sebaceous gland obstruction is observed, and inflammation caused by Masuda is observed in the connective tissue surrounding the FFA.

Therefore, drugs with anti-inflammatory effects have been used as topical drugs for treating acne, but there are only a few drugs that have anti-inflammatory effects and are effective in treating acne, and they are not effective. I can't say it's enough (and it's not satisfactory in terms of treatment either.

[Problems to be Solved by the Invention] The present inventors have proposed a method that increases the effects of conventional anti-inflammatory agents on the skin, works particularly effectively in the prevention, treatment, and treatment of acne, and that can be used on the scalp. While researching compounds that can effectively prevent dandruff, we discovered that one or more compounds selected from the herbal medicines peony, botanpi, and their extracts, as well as glycyrrhizic acid, allantoin, indomethacin, and The present invention was completed based on the discovery that an external skin preparation characterized by containing one or more anti-inflammatory agents such as derivatives thereof as an active ingredient can achieve this purpose. .

[Means for Solving the Problems] That is, the present invention provides one or more species selected from the group consisting of peonies, botanpi, and extracts thereof;
This external skin preparation is characterized by containing one or more selected from the group consisting of anti-inflammatory agents. Such external skin preparations are particularly effective in preventing, treating, and treating acne.
), ), and can be used on the scalp to effectively prevent dandruff.The structure of the present invention will be described in detail below.

In the present invention, one or more selected from the group consisting of peonies, botanpi and extracts thereof are used. Peony is a member of the Paeonia family.
ceae) Peony root, and botanpi is the dried root bark of peony, also a member of the peony family. The extract of Peony or Botanpi is obtained by extracting the root of the peony or the root end of Botanpi using water or an aqueous alcohol such as ethanol, usually at 15 to 25°C.

The amount of the extract (residue after distilling off the extraction solvent) is approximately 0.005% (wt%) or more in the entire composition. The upper limit of the blending amount is not particularly limited, but from the viewpoint of commercial value such as coloring, it is preferable to blend the dry residue up to about 10% in total.

Anti-inflammatory agents used in the present invention include glycyrrhetinic acid, glycyrrhizic acid, allantoin, epsilon aminocaproic acid, butyl flufenamate, azulene, camphor, zinc chloride, zinc white, menthol, indomethacin, ibuprofen piconol, mefenamic acid, and their Examples include derivatives. Glycyrrhizic acid, allantoin, and indomethacin are particularly preferred.

In the present invention, one or more selected from these anti-inflammatory agents may be used.

The blending amount is 0.001% or more and 20% or less,
Preferably, it is 0.01% or more and 10% or less.

The skin external preparation of the present invention contains peonies, botanpis and their extracts, and anti-inflammatory agents such as gliderritic acid, allantoin, and indomethacin, as well as exfoliating agents, vitamins, anti-occlusive agents, and dosage forms. Although different, oils, surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, etc. can be appropriately blended within the range that does not impair the effects of the present invention.

The external preparation for skin of the present invention may be in any form as long as it can be applied to the skin, such as cream, ointment, lotion, or tonic.

[Effects of the Invention] The skin external preparation according to the present invention has an excellent effect of mildly suppressing inflammation. It penetrates into the skin very well, does not cause any irritation or hormonal side effects, is particularly effective in preventing, treating, and treating acne, and can be used on the scalp to effectively prevent dandruff.

[Examples and Effects of the Invention] Example 1 Lotion Sorbitol (70%) 3.0g Glycerin 5.0g Glyderlitic Acid 0. ．． 2g water
69. Mix and dissolve 0g of these ingredients and add allantoin, 0.1g of peony extract, and 1.0g of peony extract.
0.2g sulfur
1. og polyoxyethylene hardened castor extract derivative 05g Ethanol 20.0g Fragrance
Add an appropriate amount of the mixed solution while stirring to obtain a lotion as a homogeneous solution.

Example 2 Cream beeswax 11.0g paraffin wax 6', 0g lanolin
3.0g isopropyl myristate 6. og squalane
8.0g liquid paraffin 27.
og peony extract 0.05g Saridil cup 1.55g Indomethacin 2.0g Polyoxyethylene lupicum monostearate) 1
．． 5g sorbitan monostearate 4.2g
Preservative: Mix appropriate amounts of these ingredients, heat at about 75°C to dissolve, and then heat to about 75°C, propylene glycol 2. Og borax
0.7g water
Add 27.0g of the mixture while stirring, cool, add an appropriate amount of fragrance at 55°C,
Until 5℃ (keep stirring and leave to obtain cream).

Example 3 Hair tonic ethanol 55.0g hinokitiol 0.1g mefenamic acid
0.1g menthol
0.1g Nikkor HCO-60
An appropriate amount of 1.0 g fragrance was dissolved at room temperature to obtain an alcohol phase.

Peony extract 0.7g purified water
42. og glycerin
1.0g dye
An appropriate amount of the mixture was dissolved under heating and cooled to obtain an aqueous phase.

The alcohol phase was added to the aqueous phase and solubilized to obtain a hair tonic.

Example 4 Ointment solid paraffin 10.0g peace wax 10.0g squalane
10.0g Peony extract
1.0g resorcinol
0.5g zinc white 0.5
gFragrance Appropriate amount of Vaseline
68.0 g of the above components were mixed, the mixture was heated and dissolved at 80° C., and then cooled with stirring to obtain an ointment.

The effects of the present invention will be explained in detail by briefly giving clinical examples.

(Medicine used) A lotion-type skin external preparation obtained by the following formulation and manufacturing method was used.

Peony extract 1.0gP, ○,
E, (60 mol) Hydrogenated castor oil 2.0 g Glycerin 10.0 g Dipropylene glycol 10.0 g 1.3-Butylene glycol 5.0 g Polyethylene glycol 150
0 5. 'Og or more is heated and melted at 6000. Add to this 1.0 g of glycyrrhizinic acid, cetyl isooctate, nate 10. Og squalane
5.0g methylparaben
Add and mix 1.0g of the solution heated to <60'C, and process with a homomixer to form a gel.

Next, 0.3 g of carboxyvinyl polymer and 0.08 g of sodium xametaphosphate dissolved in 10.5 g of ion-exchanged water were slowly added to this gel and dispersed with a homomixer, followed by 0.12 g of potassium hydroxide. A solution dissolved in 39.0 g of ion-exchanged water was added and mixed, and the mixture was emulsified with a homomixer to obtain a lotion-type skin preparation for external use.

As control drugs, external preparations containing only peony extract or only glycyrrhizic acid were used. Note that correction was performed using ion-exchanged water.

Case No. 1 to 10: Contains only glycyrrhizic acid.

Case No. 11-20 Contains only peony extract.

Case No. 21-30 Contains glycyrrhizic acid + peony extract.

A total of 30 men and women used the product for about one month.

(How to use) After thoroughly washing your face with soap, apply the above-mentioned lotion-type skin preparation once a day only on the skin layer.
It was applied ~3 times.

<i1J! Observation items and observation points) Observe the three symptoms of bloating, papules, and pus, and combine the severity of the individual findings to determine the severity of pre-vulgaris.
The symptoms were divided into three stages: moderate and mild. Follow-up is before treatment,
The test was conducted 1 week, 2 weeks, 3 weeks, and 4 weeks after the treatment.

(Overall improvement level) Compared to before use, the degree of improvement in symptoms due to the drug used: markedly relieved (H+), considerably relieved (4+), somewhat relieved (+)
It was divided into 5 stages: no change (±), and worsening (-).

(Usefulness) Based on the overall degree of improvement, it was judged as extremely useful (H+), quite useful (++), somewhat useful (+), and ineffective (±).

(Results) The clinical test results for a total of 30 people (6 men and 24 women) were as follows: Of the 10 people who used glycyrrhizic acid-containing topical preparations, 1 (10χ) said +1- (fairly useful), and 4 said + (somewhat useful). 40χ
), 5 people (50χ) answered ± (ineffective), and 4 out of 10 people who used topical preparations containing only peony extract (
40γ), ± (ineffective) in 6 people (60χ), out of 10 people using glycyrrhizic acid + peony extract combination topical preparation, 3 people said + (very useful) (30X), +1- (very useful)
3 people (30%), 4 people (40%) said + (Ya and useful)
The effectiveness of the present invention in treating acne was demonstrated.

Claims (2)

[Claims] (1) A skin preparation for external use, comprising one or more selected from the group consisting of peonies, botanpis, and extracts thereof, and an anti-inflammatory agent. (2) The skin external preparation according to claim 1, wherein the anti-inflammatory agent is glycyrrhizic acid, allantoin, indomethacin, or a derivative thereof.