JPH11116436A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin that contains erythritol, an anti-inflammatory component and an antimicrobial agent, manifests excellent pimple treatment effect with mild action on the skin and no hormone- like side effect and is useful for treatment of acne. SOLUTION: This preparation for external use for skin comprises (A) 0.01-10.0 wt.% of erythritol, (B) an anti-inflammatory component, in an amount of 0.0001-10.0 wt.%, when glycyrrhizic acid is used as the component B, and (C) an antimicrobial agent, in an amount of 0.001-10.0 wt.%, when cork tree bark is used as the component C. When necessary, this preparation can contain, in addition, a compound having sebum-suppressing effect such as vitamin B6 , an astringent agent such as sodium phenol-sulfate, pharmaceutical components such as vitamin A acid (or its derivative), salicylic acid, zinc or its compounds, lactic acid and the like, a keratolytic drug and a moisture retainer such as hyarulonic acid and the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin which is excellent in treating acne.

[0002]

2. Description of the Related Art Acne is a skin disease that mainly develops during puberty, and its formal name is acne vulgaris. Clinically, "acne acne is a chronic inflammatory change that occurs in pores mainly in the pilosebaceous system. Is defined. Although the pathogenesis is still largely unknown, it is generally considered to be a skin disease in which various factors are intricately intertwined while hypersecretion of sebum, keratinization of hair follicles, and bacteria in hair follicles play important roles. ing. Therefore,
External preparations for treating acne include sebum secretion inhibiting components, keratolytic components, anti-inflammatory components and / or
Or creams and ointments containing an antibacterial substance are generally used in many cases.

[0003]

However, various drawbacks have also been reported in existing acne remedies containing the various components described above. For example, female hormones, which are sebum secretion inhibiting components, suppress epidermal growth and reduce sebum secretion, but the side effects caused by these hormones are not particularly favorable for adolescent men and women. In addition, pyridoxine hydrochloride and peony extract, which have sebum-suppressing action,
Crude drugs such as burdock extract alone did not show a sufficient sebum-suppressing effect even when incorporated in creams or ointments, etc., and the effect of acne treatment was not always sufficient. further,
Sulfur compounds such as sulfur and selenium disulfide, which are typical examples of the keratolytic components, do not have side effects like the female hormones described above, but often cause skin irritation and skin bulking when used continuously.

[0004] In view of such circumstances, an object of the present invention is to provide a skin external preparation for acne treatment which has no hormonal side effects, is mild to the skin, and has an excellent acne treatment effect. .

[0005]

The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, an external preparation for skin containing erythritol, an anti-inflammatory component and an antibacterial component has been developed.
The present inventors have found that the present invention is gentle on the skin, further suppresses abnormal keratinization, and satisfactorily achieves the purpose of acne treatment, thereby completing the present invention.

[0006] That is, a first aspect of the present invention is a skin external preparation characterized by containing erythritol, an anti-inflammatory component and an antibacterial component. The second aspect of the present invention is an external preparation for acne treatment, which comprises erythritol, an anti-inflammatory component and an antibacterial component. A third aspect of the present invention is a remedy for acne comprising erythritol, an anti-inflammatory component and an antibacterial component. In the present invention, glycyrrhizic acid or a derivative thereof is preferable as the anti-inflammatory component, and oak extract is preferable as the antibacterial component.

Hereinafter, embodiments of the present invention will be described. Erythritol used in the present invention is meso-
Also called erythritol, it is a 4-carbon sugar alcohol contained in lichens, basidiomycetes, fruits and the like in the natural world.
It is known that it has a higher moisturizing effect than before, and it is applied to cosmetics and the like, but it is known that a combination of an anti-inflammatory agent and an antibacterial component has a high acne treatment effect as in the present invention. Absent.

[0008] The amount of erythritol which can be incorporated as an active ingredient in the skin external preparation of the present invention is preferably 0.01% by weight or more and 10.0% by weight or less, and more preferably 0.1% by weight or less based on the whole skin external preparation. , 5.0% by weight or less is particularly preferred. If the amount of erythritol is less than 0.01% by weight based on the total amount of the external preparation for skin, it is not preferable because the desired effect is hardly exhibited, and if it exceeds 10.0% by weight, stickiness becomes remarkable and the formulation is not preferred. It is not preferable because the acne suppression effect corresponding to the amount tends not to increase.

The anti-inflammatory component that can be incorporated into the external preparation for skin of the present invention is not particularly limited as long as it has a function of suppressing inflammation and is appropriate as a component of the external preparation for skin in terms of safety and the like. Not something.

[0010] Specifically, components conventionally used as anti-inflammatory components, such as allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid or a derivative thereof, glutathione, acyl sarcosine acid, licorice extract component, orchid extract component, and sicon Extract component, Western saw grass extract component, Hilihari grass extract component, Aloe extract component, Rigix japonicus extract component,
Examples of the components include a corn extract, a mallow extract, a corn extract, a horsetail extract, a saxifrage extract, an arnica extract, a lily plant extract, a mugwort extract, a gardenia extract, and a chamomile extract.

Glycyrrhizic acid or a derivative thereof is particularly preferred as an anti-inflammatory component to be added to the external preparation for skin of the present invention, because it is particularly excellent in stability and usability.

These anti-inflammatory components can be used alone in the external preparation for skin of the present invention, but if necessary, two or more of them can be combined in the external preparation for skin of the present invention. It is possible.

The amount of the anti-inflammatory component in the external preparation for skin of the present invention can be appropriately adjusted according to the type of the anti-inflammatory component to be specifically mixed, and is not particularly limited. For example, in the case of glycyrrhizic acid or a salt thereof suitable for being incorporated into the external preparation for skin of the present invention, the amount is preferably 0.0001% by weight or more and 10.0% by weight or less, and 0.01% by weight or less based on the whole external preparation for skin. It is particularly preferable that the content be not less than 5.0% by weight and not more than 5.0% by weight. In this case, if the amount is less than 0.0001% by weight based on the total amount of the external preparation for skin, it is not preferable because the desired anti-inflammatory effect is hardly exhibited. If the amount exceeds 10.0% by weight, the anti-inflammatory effect corresponding to the amount is not sufficient. It is not preferable because no increase is observed.

Further, the antibacterial component which can be added to the external preparation for skin of the present invention may be any antibacterial component as long as it has a function of suppressing the growth of acne bacteria and is suitable as a component of the external preparation for skin in terms of safety and the like. It is not limited.

Specifically, components conventionally used for controlling acne as antibacterial components, for example, oak extract, hinokitiol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, chlorhexidine glucoconsan salt, halo Carbane, chlorophenesin, benzethonium chloride, benzalkonium chloride, lysozyme chloride, alkyldiaminoethylglycine hydrochloride, isopropylmethylphenol, benzoic acid, photosensitizer 201
No., thymol, hexachlorophen, berberine, thioxolone, salicylic acid and derivatives thereof.

As an antibacterial component to be added to the external preparation for skin of the present invention, oak extract is particularly preferable in that it is particularly excellent in stability and usability.

These antimicrobial components can be used alone in the external preparation for skin of the present invention. However, if necessary, two or more of them can be combined in the external preparation for skin of the present invention. It is possible.

The amount of the above antibacterial component in the external preparation for skin of the present invention can be appropriately adjusted according to the type of the antibacterial component to be concretely added, and is not particularly limited. For example, in the case of an oak extract suitable for blending with the external preparation for skin of the present invention, 0.0001 with respect to the whole external preparation for skin.
% By weight and not more than 10.0% by weight.
Particularly preferred is 1% by weight or more and 5.0% by weight or less. In this case, if the amount is less than 0.0001% by weight based on the total amount of the external preparation for skin, the desired antibacterial effect is hardly exhibited, so that it is not preferable. It is not preferable because no increase is observed.

As described above, by combining erythritol, an anti-inflammatory component and an antibacterial component in combination as active ingredients, an external preparation for acne treatment which is mild on the skin and can suppress abnormal keratinization. Is provided.

Further, in addition to the above-mentioned essential active ingredients, other medicinal ingredients are exerted by blending the medicinal ingredients in a skin external preparation within a range not to impair the intended effect of the present invention. Within the range in which the effect is expected.

For example, a compound having a sebum-suppressing effect such as vitamin B6, an astringent such as sodium sulfocarbonate, vitamin A acid and its derivatives, salicylic acid, zinc and its compounds, and lactic acid and other medicinal ingredients are contained in the skin external preparation of the present invention. Can be blended. In addition, a humectant such as a keratolytic agent or hyaluronic acid can be incorporated into the external preparation for skin of the present invention.

It should be noted that the "other drugs and the like" that can be incorporated into the external preparation for skin of the present invention are not limited to those exemplified here, and that only one of these "other drugs and the like" is used. It is needless to say that two or more kinds can be combined in the external preparation for skin of the present invention as needed.

In addition, depending on the specific dosage form and form of the external preparation for skin of the present invention, generally known base components and the like can be used as the base components and the like of the external preparation for skin of the present invention. That is, various oils, surfactants, water, ethanol, thickeners,
Fragrances, pigments and the like can be used as a base component and the like of the external preparation for skin of the present invention as long as the desired effects of the present invention are not impaired.

The form that the external preparation for skin of the present invention can take is not particularly limited, and any form such as cream, lotion, emulsion, pack, white powder, ointment and the like that can be applied to the outer skin can be selected.

[0025]

EXAMPLES Next, the present invention will be described more specifically with reference to examples and the like, but the present invention is not limited thereto. Unless otherwise specified, the compounding amount is% by weight based on the whole skin external preparation. Prior to the examples, test methods and criteria used for evaluating the skin external preparation of the present invention will be described.

Test Methods / Criteria (Drugs Used) Based on the formulation of each skin external preparation described below, the acne-suppressing effect of a skin external preparation manufactured by an ordinary method was measured.

(Used) 120 men and women between the ages of 13 and 20 suffering from acne. (20 people per group) (Method of use and date of observation) After thoroughly washing the face with toilet soap, each topical skin preparation was applied only on the rash 2 times a day.
塗布 3 times and the affected area was observed 4 weeks later.

(Overall degree of improvement) The symptoms were divided into two stages: (a) indicating that the symptom was improved by the drug used before use, and (b) indicating that the condition was unchanged or worsened. (Evaluation of usefulness) The overall improvement was evaluated as follows. ◎: 15 or more out of 20 (a) ○: 10 to 14 out of 20 (a) △: 5 to 9 out of 20 (a) ×: 4 or less out of 20 (a)

Example 1, Comparative Examples 1-4 A lotion-type skin external preparation having the formulation shown in Table 1 was prepared, and its usefulness was evaluated by the above method. The results are shown in Table 1.

[0030]

[Table 1] 例 Example Comparative example Component / sample name 試 料 ──── ──────── 1 1 2 3 4 ────────────────────────────── Erythritol 1.0-1.0--Glycyrrhizin Dipotassium acid 0.1 − − 0.1 − Oak extract 0.05 − − − 0.05 Sorbitol (70%) 3.0 3.0 3.0 3.0 3.0 Glycerin 5.0 5.0 5.0 5.0 5.0 POE (60) hydrogenated castor oil derivative 0.5 0.5 0.5 0.5 0.5 Ethanol 20.0 20.0 20.0 20.0 20.0 Purified water Residue Residue Residue Residue Residue ────────────────────────────── Utility ◎ × △ △ △ ────── ────────────────────────

As shown in Table 1, the external preparation for skin of the present invention comprising erythritol, dipotassium glycyrrhizinate as an anti-inflammatory component, and oak extract as an antibacterial component,
It is more excellent in acne suppression effect than the lotion of each comparative example.

Formulation examples of the external preparation for skin of the present invention in various dosage forms are shown below. The external preparation for skin of the present invention in each Example was also produced by a conventional method corresponding to the specific dosage form. When the above-mentioned tests and evaluations were performed on the skin external preparations of the present invention in each of the examples, all the above-mentioned evaluation results of the usefulness were “性”.

Example 3 Lotion Compounding Amount (% by Weight) (1) Erythritol 0.5 (2) Dipotassium glycyrrhizinate 0.05 (3) Oubaku Extract 0.1 (4) Sulfolite Sodium Carbonate 0.05 (5) Glycerin 4.0 (6) 1,3-butylene glycol 4.0 (7) Ethanol 7.0 (8) Polyoxyethylene oleyl alcohol 0.5 (9) Methylparaben 0.05 (10) Citric acid 0.01 (11 ) Sodium citrate 0.1 (12) Fragrance 0.05 (13) Purified water residue

Example 4 Cream Content (% by Weight) (1) Cetostearyl Alcohol 3.5 (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced Lanolin 5.0 (5) Ethyl Paraben 0 0.3 (6) polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) stearic acid monoglyceride 2.0 (8) fragrance 0.03 (9) erythritol 5.0 (10) allantoin 0.1 ( 11) Hinokitiol 0.05 (12) 1,3-butylene glycol 5.0 (13) Glycerin 5.0 (14) Purified water residue

Example 5 Emulsion Compounding amount (% by weight) (1) Erythritol 1.0 (2) Chamomile extract 0.1 (3) Benzoic acid 0.1 (4) Stearic acid 1.5 (5) Cetyl alcohol 0 2.5 (6) Beeswax 2.0 (7) Polyoxyethylene (10) monooleate 1.0 (8) Glycerin monostearate 1.0 (9) Propylene glycol 5.0 (10) Ethanol 3. 0 (11) Ethyl paraben 0.3 (12) Fragrance 0.03 (13) Purified water residue

Example 6 Ointment Compounding amount (% by weight) (1) Erythritol 2.0 (2) Glycyrrhetinic acid 0.1 (3) Salicylic acid 0.1 (4) Stearyl alcohol 18.0 (5) Mokurou 20.0 (6) Polyoxyethylene (10) monooleate 0.25 (7) Glycerin monostearate 0.25 (8) Vaseline 40.0 (9) Purified water residue

[0037]

As described above, according to the present invention, it is possible to provide an external preparation for skin that is mild to the skin and has an excellent acne treatment effect.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 9/06 A61K 9/06 G 35/78 ADA 35/78 ADAW

Claims (5)

[Claims] 1. An external preparation for skin, comprising erythritol, an anti-inflammatory component and an antibacterial component. 2. The external preparation for skin according to claim 1, wherein the anti-inflammatory component is glycyrrhizic acid or a derivative thereof. 3. The external preparation for skin according to claim 1, wherein the antibacterial component is an extract of oak. 4. The external preparation for skin according to claim 1, wherein the external preparation for skin is an external preparation for acne treatment. 5. A therapeutic agent for acne, comprising erythritol, an anti-inflammatory component and an antibacterial component.