JP2003238379A - Skin care preparation and hair cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a skin cosmetic or a hair cosmetic which has effectively inhibitory action on sebum secretion and excellent sense of use. <P>SOLUTION: The skin cosmetic comprises a sebum secretion inhibitor, licochalcone A and a germicidal/antimicrobial agent and has excellently preventing and treating effect on sebum secretion. The hair cosmetic effectively controls dandruff and itch and prevents fallen hair by suppressing sebum secretion. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic and a hair cosmetic having an excellent sebum secretion inhibitory action against excessive sebum from the epidermis.

[0002]

2. Description of the Related Art A small amount of fat is constantly secreted from the surface of the skin, but when the secretion of this fat called sebum becomes excessively active, seborrhea, acne, comedones, papules, pustules, and other diseases. Cause of.

Excessive secretion of sebum often occurs when the androgen, collectively referred to as androgen, acts excessively. In that case, secretion of sebum can be optimized by suppressing the action of androgen.

[0004] Testosterone, which is a typical androgen, does not act as it is in the molecular form secreted from its producing organ, but enters into the cells of the target organ and undergoes 5α-dihydrotestosterone (5α-) by testosterone 5α-reductase. It has been confirmed that after being reduced to DHT, it binds to the receptor and exerts an action as an androgen. Therefore, testosterone is used as a means to prevent disorders caused by overactivity of testosterone.
There are a method of inhibiting the action of testosterone 5α-reductase, which reduces to α-DHT, and a method of inhibiting the binding of 5α-DHT generated from testosterone to the receptor, thereby preventing the male hormone action.

The sebum secreted by the sebaceous glands of the skin and scalp keeps the skin soft and smooth, and is supplied to the hair as necessary and appropriate oil to maintain the suppleness and beauty of the hair. It is an effective ingredient and is required for skin and hair. Sebum also plays an important role in preventing various irritants from the outside from invading the skin or the scalp surface, while preventing the loss of water from the skin or the horny layer of the scalp.

[0006]

An object of the present invention is to effectively suppress sebum secretion by adding a combination of a sebum secretion inhibitor and lycochalcone A, and further a bactericidal / antibacterial agent, and to provide an excellent feeling in use. To provide skin cosmetics or hair cosmetics.

[0007]

The skin cosmetic according to the present invention is characterized by containing a sebum secretion inhibitor, lycochalcone A, and a bactericidal / antibacterial agent. The synergistic action of these essential components prevents sebum secretion and It has excellent therapeutic effect. Furthermore, the hair cosmetic composition according to the present invention suppresses sebum secretion, thereby effectively suppressing dandruff and itching by a synergistic action of components, and preventing hair loss.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Sebum secretion inhibitors include baicalin, astilbin, amperopsin, berberine, diethylstilbentrol, hexestrol, tocopherol acetate, cepharanthin, arnica extract, oolong tea extract, hypericum extract, tolmentilla extract, salvia. The extract is, but is not limited to, an extract, a yellow-fruit extract, a wisteria tea extract, a thyme extract, a carambola extract, a narcissus extract, and the like, and any substance having an action of suppressing sebum secretion may be used.

Ricochalcone A is a yellow crystal which is soluble in ethanol, ethyl acetate, methylene chloride, chloroform and the like but insoluble in water. Although it can be synthesized, legume licorice (Glycyrrhiza inflata, Gly
Cyrrhiza echinata etc.), it may be extracted and purified using the above organic solvent and used.

The bactericidal and antibacterial agents contained in the skin cosmetics and hair cosmetics of the present invention together with the sebum secretion inhibitor and lycochalcone A are benzoic acid, sodium benzoate, paraoxybenzoic acid ester, distearylmethylammonium chloride, benzethonium chloride, Benzalkonium chloride,
Alkyldiaminoethylglycine chloride, chlorhexidine hydrochloride, orthophenylphenol, photosensitive dye 101
No., photosensitive dye 201, photosensitive dye 301, photosensitive dye 4
No. 01, salicylic acid, sodium salicylate, sorbic acid, halocarban, resorcin, isopropylmethylphenol, parachloroethanol, phenoxyethanol, bisabolol, hinokitiol, 1-menthol,
Piroctone olacin, zinc pyrithione, d-camphor, triclosan, irgasan DP-300, hexachlorophene, chitosan, chitosan degradation product, waremoko extract, kujin extract, neem leaf extract, loquat extract, porcupine extract, hop extract, yucca extract,
There are aloe extract, cinnamon extract, zedoary extract and the like. One or more of these bactericidal / antibacterial agents may be contained in the cosmetic of the present invention.

When the sebum secretion inhibitor or bactericidal / antibacterial agent is a plant extract, the means for obtaining the plant extract is to use water, ethanol, 1,3-butylene glycol, or water, ethanol, 1,3-butylene glycol, A hydrophilic organic solvent such as propylene glycol or a mixed solution thereof may be added, and the mixture may be left standing at room temperature or under heating for 1 to 10 hours or stirred to perform extraction.
The obtained extract can be used as it is or as an extract obtained by distilling the solvent under reduced pressure and drying it in the cosmetic of the present invention.

The preferable amount of the sebum secretion inhibitor to be incorporated in the cosmetic is 0.0001 to 3.0% by weight. In addition, the suitable compounding ratio of Ricochalcone A to cosmetics is 0.001 to 1.0.
% By weight. In addition, the preferable blending ratio of the sterilizing / antibacterial agent is 0.
It is 0001 to 10% by weight. Needless to say, when the bactericidal / antibacterial agent is a plant extract having a coloring or a peculiar odor, it is desirable to mix it in a range that does not adversely affect the appearance and feeling of use of the cosmetic composition.

Examples of the dosage forms of the skin cosmetics and hair cosmetics of the present invention include skin cosmetics such as lotions, creams, emulsions, packs and lip balms, and hair cosmetics such as hair tonics, shampoos and conditioners. is there.

[0014]

[Test Example 1] The testosterone 5α-reductase inhibitory action of lycochalcone A was tested by the following test method.

Test method: Testosterone (Tokyo Kasei) 4.
Dissolve 2 mg in 1 ml of propylene glycol, part 2
To 0 μl, 825 μl of 5 mM Tris-HCl buffer (pH 7.2) in which NADPH (manufactured by Oriental Yeast Co., Ltd.) was dissolved to a concentration of 1 mg / ml was added and mixed. Furthermore, 80 μl of an ethanol solution of the sample and 75 μl of S-9 (rat liver homogenate; manufactured by Oriental Yeast Co., Ltd.)
Are mixed and incubated at 37 ° C. for 30 minutes. Then, the reaction is stopped by adding 1 ml of methylene chloride, the methylene chloride layer is separated, and the reaction products such as dihydroxytestosterone and androstanediol are quantified by gas chromatography. Separately, as a control, when the same amount of the solvent is added instead of the sample solution, the same treatment and analysis are performed. The ratio of the amount of the reaction product when the sample was added to the amount of the reaction product when the sample was not added was calculated and used as the testosterone 5α-reductase inhibition rate.
In the above method, the concentration of lycochalcone A in the reaction solution is variously changed to obtain the testosterone 5α-reductase inhibitory rate at each concentration, and the concentration at which the enzyme activity is inhibited by 50% is determined from the results by interpolation.

[Table 1] Sample 50% Inhibitory Concentration (ppm) Lycochalcone A 570 Baicalin 475 Carambola Extract 560 Sodium Benzoate> 2000 Hinokitiol> 2000 Lycochalcone A: Baicalin (1: 1) 225 Lycochalcone A: Carambola Extract (1: 1) ) 248 lycochalcone A: baicalin: sodium benzoate (1: 1: 0.5) 315 lycochalcone A: baicalin: hinokitiol (1: 1: 0.5) 330

[Test Example 2] A solution of the following formulation was fixed on the left side of the forehead of 5 subjects (A group, B group, C group) of each of 3 groups of healthy test subjects with absorbent cotton using adhesive tape. Then, absorbent cotton impregnated with only 50% ethanol is fixed on the right side. After 8 hours, each absorbent cotton is removed, extracted with 50% ethanol to recover the sebum absorbed in the absorbent cotton, and the squalene in it is quantified by gas chromatography. The sebum secretion inhibitory rate by lycochalcone A is calculated from the difference in the amount of squalene quantified for the left and right absorbent cotton.

The sample used for the group A was prepared by mixing 1: 1 lycochalcone A and baicalin in a 50% ethanol solution to prepare a 0.01% concentration. The sample used for the group B was a 50% ethanol solution in lycochalcone A. And baicalin and sodium benzoate were mixed at a ratio of 1: 1: 0.5 to prepare a 0.01% concentration. The sample used for group C was 50% ethanol solution containing 0.0% baicalin.
The one prepared to have a concentration of 1% was used.

[0019] Table 2 recovered amount of sebum specimen A Group (mg / ^{4 cm} 2) A group sample 0.091 ± 0.064 control unit 0.153 ± 0.080 sebum secretion inhibition rate (%) 40 .5

[0020] Table 3 collected sebum amount of specimen B Group (mg / ^{4 cm} 2) Group B samples 0.112 ± 0.075 control unit 0.181 ± 0.065 sebum secretion inhibition rate (%) 38 .1

[0021] Table 4 recovered amount of sebum specimen C Group (mg / ^{4 cm} 2) Group C samples 0.127 ± 0.083 control unit 0.179 ± 0.054 sebum secretion inhibition rate (%) 29 .1

[0022] [Formulation Example 1]   A lotion was manufactured by a conventional method. 15 parts of ethanol Ricochalcone A 0.2 part Yellow birch extract 0.2 parts Dipotassium glycyrrhizinate 0.1 parts Oil-soluble licorice extract 0.1 part Crassulaceae extract 0.1 part Phenoxyethanol 0.05 parts Polyoxyethylene sorbitan monolaurate (20EO) 1.5 parts Polyoxyethylene lauryl ether (20EO) 0.5 part Fragrance suitable amount 1,3-butylene glycol 4.0 parts Oleyl alcohol 4.0 parts Purified water balance (total 100)

[0023] [Formulation Example 2]   A cream was produced by a conventional method. Ricochalcone A 0.2 part Beeswax 10.0 5.0 parts of cetanol Hydrophilic lanolin 8.0 parts Squalane 32.0 copies Glyceryl monostearate 2.5 parts 2.0 parts of polyoxyethylene sorbitan monolaurate (20EO) Polyethylene glycol 5.0 parts 5.0 parts of ethanol Bisabolol 0.05 part Fragrance suitable amount Purified water balance (total 100)

   ─────────────────────────────────────────────────── ─── Continued front page    F term (reference) 4C083 AA111 AA112 AC012 AC022                       AC031 AC072 AC082 AC102                       AC122 AC171 AC172 AC182                       AC251 AC311 AC422 AC442                       AC471 AC472 AC481 AC691                       AC711 AC741 AC811 AC841                       AC842 AC851 AC931 AD042                       AD321 AD491 AD512 AD531                       AD532 AD551 AD661 BB48                       BB51 CC04 CC05

Claims (4)

[Claims] 1. A skin cosmetic and a hair cosmetic, which contain a sebum secretion inhibitor and lycochalcone A. 2. The sebum secretion inhibitor according to claim 1, wherein baicalin, astilbin, amperpsin, berberine, diethylstilbentrol, hexestrol, tocopherol acetate, cepharanthin, arnica extract, oolong tea extract, Hypericum perforatum extract, Tormentilla extract. , Salvia extract, yellow husk extract, wisteria tea extract, thyme extract, carambola extract, nansan extract 1
2. The skin cosmetics and hair cosmetics according to claim 1, wherein one kind or two or more kinds are blended. 3. A skin cosmetic and a hair cosmetic characterized in that the skin cosmetic and the hair cosmetic according to claim 1 contain a bactericidal / antibacterial agent. 4. The bactericidal / antibacterial agent according to claim 3, wherein benzoic acid is used.
Sodium benzoate, paraoxybenzoic acid ester, distearylmethylammonium chloride, benzethonium chloride, benzalkonium chloride, alkyldiaminoethylglycine chloride, chlorhexidine hydrochloride, orthophenylphenol, photosensitive dye No. 101, photosensitive dye No. 201, photosensitive dye No. 301 , Photosensitizing dye No. 401, salicylic acid, sodium salicylate, sorbic acid, halocarban, resorcin, isopropylmethylphenol, parachloroethanol, phenoxyethanol, bisabolol, hinokitiol, l-menthol, piroctone olacin, zinc pyrithione, d-camphor, triclosan, Irgasan D
P-300, hexachlorophen, chitosan, decomposed product of chitosan, cabbage extract, kujin extract, nematode extract, loquat extract, sumac extract, hop extract,
The skin cosmetics and hair cosmetics according to claim 3, wherein one or more kinds of yucca extract, aloe extract, cinnamon bark extract, and zedoary extract are blended.