JP3082994B2 - Whitening cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition containing a specific plant extract and having an excellent whitening effect and having high safety and stability.

[0002]

2. Description of the Related Art Conventionally, whitening cosmetics have been of great interest in improving skin darkness, blemishes, freckles, and the like. In these, ascorbic acid, glutathione, colloidal sulfur and the like are effective. It has been formulated as an ingredient.

There are also examples of using various medicinal plant extracts, plant-derived gallic acid, geraniin and the like. further,
Whitening ingredients such as kojic acid and glucobutanoside derivative arbutin have also recently been used.

[0004]

However, ascorbic acid is liable to be oxidized and unstable, and glutathione and colloidal sulfur have disadvantages in that a peculiar off-odor and precipitation occur.

[0005] In addition, the conventional medicinal plant extract has problems that the effect is still insufficient and the quality is not constant. Further, for kojic acid and the like, consideration must be given to maintaining the stability and the like. In addition,
In some cases, side effects occurred due to continuous use.

An object of the present invention is to solve such a problem and to provide a whitening cosmetic which is excellent in whitening effect and high in stability and safety.

[0007]

Means for Solving the Problems Since cosmetics are used daily, the active ingredients to be blended with the cosmetics are mild in action, exhibit a sufficient effect by continuous use, and have no side effects due to continuous use. Is desired. From this viewpoint, substances derived from natural products, particularly extracts of medicinal plants, are preferable. However, in order to solve the above-mentioned problems in the effectiveness of the action, the stability of quality, and the like, we have proposed the use of plant extracts. Among them, those having an effective and mild skin whitening effect and having high stability were screened.

As a result, knotweed ( Polygonum cuspidat)
um Sieb. et Zucc.), Honey beebird ( Polygonum)
cuspidatum Sieb. et Zucc.var.hachidyoense Ohw
i) and Knotweed ( Polygonum sachalinense Fr.
Schm.), A high inhibitory effect on tyrosinase activity was found. These extracts had no adverse effects on the skin such as skin irritation and contact sensitization, and did not inactivate the tyrosinase activity inhibitory effect when formulated into cosmetics, and were stable in quality.

[0009] Therefore, the Japanese knotweed ( Polygonum cuspidat)
um Sieb. et Zucc.), Honey beebird ( Polygonum)
cuspidatum Sieb. et Zucc.var.hachidyoense Ohw
i) and Knotweed ( Polygonum sachalinense Fr.
Schm.), And by blending one or more plant extracts selected from the above, a mild whitening effect can be expected and a sufficient whitening effect can be expected, and a whitening cosmetic with high safety and stability is completed. Reached.

[0010]

The plant extract used in the present invention is generally dried or minced from a raw plant and mixed with 10 to 30 parts of an organic solvent such as ethanol or propylene glycol, or a mixture of these organic solvents, or After adding 100 parts of a mixture of water and the above-mentioned organic solvent, and extracting at room temperature with stirring for about one week, the mixture is filtered to obtain a filtrate. The whitening effect of these plant extracts was evaluated based on the inhibition rate of tyrosinase activity. The evaluation was performed as follows.

First, 10 g of dried plant chips were placed in 100 ml of 50% by weight ethanol and extracted at room temperature for one week. This plant extract was diluted 100 times with purified water to prepare a sample solution. Next, tyrosinase (50,000)
units, manufactured by Sigma) were diluted 600 times with purified water to obtain an enzyme solution. The substrate solution was prepared by dissolving 50 mg of tyrosine in 100 ml of purified water.

[0012] The enzymatic reaction is performed in a sample solution 2 ml, 1/15
M phosphate buffer (pH 6.8) 2 ml, substrate solution 0.5
The mixture was mixed with 0.5 ml of the enzyme solution and incubated at 37 ° C. for 1 hour. After the reaction, the absorbance (As) at 475 nm was measured. Further, the same reaction was performed in a system in which purified water was added instead of the sample solution and in a system in which purified water was added instead of the substrate solution, and the absorbance (Ab and A0) in each case was measured. The tyrosinase activity inhibition rate was determined by the following equation .

(Equation 1)

The measurement results are shown in Table 1. As is clear from Table 1, all of the plant extracts used in the present invention exhibit a significantly high tyrosinase activity inhibition rate, reduce the production of dopachrome from tyrosine, and exhibit an effective whitening effect. there were.

[Table 1]

In the present invention, the amount of the above plant extract to be added to the whitening cosmetic is suitably 0.001 to 20% by weight. If the amount is less than 0.001% by weight, a sufficient whitening effect cannot be obtained, but the whitening effect is so strong that there is no need to add a large amount. If it exceeds 20% by weight, the stability of cosmetics etc. May be affected.

Further, the whitening cosmetics according to the present invention include lotions such as a soft lotion, an astringent lotion, and a lotion for washing;
Emollient cream, moisture cream, massage cream, cleansing cream, make-up cream
Various formulations such as creams such as cream, emollient emulsion, moisture emulsion, nourishing emulsion, cleansing emulsion, etc., packs such as jelly pack, peel-off pack, powder pack, and face wash. it can.

Further, other active ingredients such as a humectant, an anti-inflammatory agent, an ultraviolet absorber and the like can be used in combination, and a medicated cosmetic such as a sunscreen cosmetic, a skin protective cosmetic, a rough skin improving cosmetic or the like. It can also be provided as a quasi-drug or the like.

[0017]

Next, the present invention will be described in more detail with reference to examples.

Example 1 is a whitening cream according to the present invention. The formulations are shown in Table 2. In Table 2, (1) to (7) were heated and dissolved at 75 ° C, and (10) to (13), which were heated and dissolved at 75 ° C, were added to emulsify, cooled, and cooled to 50 ° C at (8). , (9) is added and further cooled to obtain a whitening cream.

[Table 2]

Example 2 is a whitening emulsion according to the present invention.
The formulation is shown in Table 3. In Table 3, (1) to (8) were heated and dissolved at 75 ° C, and (11) to (15), which were heated and dissolved at 75 ° C, were added to emulsify, cooled, and cooled to 50 ° C at (9). ) To (10) and further cooling to a whitening emulsion.

[Table 3]

In Example 1, Comparative Example 1 was obtained by removing the knotweed extract (9) and adjusting the total amount to 100% by weight with purified water. Similarly, in Example 2, Comparative Example 2 was obtained by removing the knotweed extract of (10) and adjusting the total amount to 100% by weight with purified water.

The above Examples and Comparative Examples were subjected to use tests to evaluate the whitening effect. In the use test, 40 female panelists aged 30 to 40 years old who were worried about spots and freckles were randomly divided into 4 groups of 10 each, and each group of Examples 1 and 2 and Comparative Examples 1 and 2 were blinded. Was used.
After washing the face twice a day, morning and night, an appropriate amount of the sample was applied to the face, and the use was continued for two months. The whitening effect was evaluated by observing the condition of spots and freckles on the face after the use test. Table 4 shows the results.

[Table 4]

In Table 4, in the group using Example 1, improvement of spots and freckles was observed in 9 persons, and the remaining 1
Some improvement was also observed in the names. The effective rate in improving spots and freckles was 100%. Also in the use group of Example 2, stains and freckles were improved in eight persons, and the remaining two persons were also slightly improved, and the effectiveness in improving stains and freckles was similarly 100%. On the other hand, in the group using Comparative Example 1, none of the panelists recognized improvement in spots and freckles. In the group of Comparative Example 2, the use of a small amount of the ascorbic acid derivative slightly improved one person, but no improvement was observed in the remaining nine people.

Furthermore, during the above use test period, none of the groups using any of the examples complained of skin irritation such as pain and itchiness and skin disorders such as allergic reaction. In addition, there was no decrease in the quality of the cosmetic such as sedimentation or deterioration of the components.

[0024]

As described above, according to the present invention, it is possible to provide a whitening cosmetic which exhibits an effective whitening effect and is excellent in stability and safety.

Claims (1)

(57) [Claims] 1. A knotweed ( Polygonum cuspidatum Sieb.
et Zucc.), Honey beebird ( Polygonum cuspida)
tum Sieb. et Zucc. var. hachidyoense Ohwi), and Ooitadori (Polygonum sachalinense Fr. Schm. 1 kind selected from) or characterized by blending an extract of two or more plants, whitening cosmetics.