JP2000169329A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition capable of imparting moistness to skin due to humectant effects possessed thereby, manifesting excellent beautifying and whitening effects due to an antityrosinase activity possessed thereby and providing white and beautiful skin by utilization thereof for suppression or treatment of pigmentation such as dermal stains, ephelides or dark skin. SOLUTION: The characteristic of this cosmetic composition is to contain Lonicerae Flos and/or an extract thereof. The Lonicerae Flos is a dried substance of a flower and/or a bud of one or more species of plants in Lonicera japonica Thunb. and its allied species.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition, which has a moisturizing effect to moisturize the skin and exhibits an excellent whitening effect by having an anti-tyrosinase activity. , Used to control or treat pigmentation such as spots, freckles, and black and white
An object of the present invention is to provide a cosmetic composition capable of providing fair and beautiful skin.

[0002]

2. Description of the Related Art Various components are blended in cosmetics according to the purpose. For example, moisturizers have been incorporated into many cosmetics in order to moisturize dry skin and maintain freshness. That is, if the moisturizing property of the skin decreases due to aging or other causes, the skin becomes dry and loses the flexibility and elasticity of the skin, and as a result, the skin may become rough or wrinkles may occur. Moisturizers are included to prevent and maintain healthy skin. As the humectant, conventionally, glycerin, propylene glycol,
1,3-butylene glycol, polyhydric alcohol, pyrrolidone carboxylic acid, saccharides, amino acids, collagen and the like have been used.

[0003] A whitening agent is also one of the components blended in many cosmetics. Whitening agents are formulated to improve, alleviate or prevent pigmentation such as spots, freckles, and black and white, and suppress the activity of tyrosinase, causing melanin pigment, which causes pigmentation, to spread on the skin. It has the function of suppressing deposition. Recently, since many people prefer fair skin, many cosmetics, such as milky lotions for whitening and lotions for whitening, have been created which claim the effect of whitening agents. As this whitening agent, ascorbic acid,
Kojic acid, arbutin, glutathione, sulfur preparations and the like have been used.

[0004]

However, moisturizing agents and whitening agents conventionally used have the following problems. That is, the moisturizing agents conventionally used have the problem that the skin damage due to the compounding is increased and the safety to the skin is low. For example, glycerin has not only a moisturizing ability but also a hygroscopic ability, and thus has a disadvantage that water in the stratum corneum is deprived, causing skin inflammation and darkening of the entire skin. on the other hand,
Conventionally used whitening agents are not satisfactory in their whitening effect, and glutathione and sulfur preparations have a peculiar off-odor, and may cause precipitation when mixed with water-soluble cosmetics. However, it cannot be used as a general additive for cosmetics.

[0005] Therefore, it is desired to create a moisturizer having a high moisturizing property and excellent safety and a whitening agent having a high whitening effect and which can be widely used as an additive for cosmetics. After intensive research on moisturizing agents and whitening agents with excellent safety from the origin, they found that gold and silver flowers used in Japanese and Chinese medicine have both a moisturizing effect and a whitening effect, and completed the present invention. Reached.

[0006]

That is, the invention according to claim 1 relates to a cosmetic composition characterized by containing gold and silver flowers and / or an extract thereof. , The gold and silver flowers are honeysuckle (Lonicera japonica T
_2. The cosmetic composition according to claim 1, wherein the composition is obtained by drying flowers and / or buds of at least one plant of _HUNB .) And its closely related species.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The cosmetic composition according to the present invention comprises:
Gold and silver flowers are used. These gold and silver flowers are honeysuckle family
Dried flowers and buds of the genus L.
U. In addition, dried leaves, stems and roots are called Shinobi.
I have. In general, honeysuckle among honeysuckle plants
La (Lonicera japonica T_HUNB.) Dried flowers and buds
Are called gold and silver flowers.
Dried flowers and buds of plants, or of these plants
A mixture of dried flowers and buds is also called gold and silver flower
I have. Honeysuckle (Lonicera japonica T_HUNBRelated species of.)
As a member of the genus, L. maackii M_AXIM., L. chinensis W
_ATSON, L.similis H_EMSL, L. tragophylla H_EMSL. L.pa
mpaninii L_EVL., L.hypoglauca M_IQ., L. hypoglauca M
_IQ, subsp.nudiflora H _su et H.J.W_ANG, L.macranthoid
es H_AND.-M_AZZ.And the like.
In addition, the above honeysuckle (Lonicera japonica T_HUNB.) And
And / or buds of one or more plants of the species
Is preferably used.

[0008] Gold and silver flowers include waxy substances such as seryl alcohol, sterin, arachinic acid, myristic acid, elaidic acid, linolenic acid and linoleic acid, diterpenes such as 3α-hydroxymanoyl oxide, luteolin and luteolin-7-lamb. Noglucoside, inositol and the like are contained. The extract of gold and silver flowers shows a mild preventive effect on peptic stomach ulcers, and intestinal motility apparently causes sympathetic nerve excitation, parasympathetic nerve suppression, and decreased automatic motor amplitude and tone due to smooth muscle paralysis. It has also been found that the water-based extract has strong antibacterial activity against several types of Gram-negative bacteria and Gram-positive bacteria. As a medicinal function of gold and silver flowers, it is known to have the effect of purifying the heat of the wind temperature and resolving the poison in the blood. , Has been applied to poisons. Furthermore, the black roast has the effect of cool blood and hemostasis, and is used as a hemostat. Gold and silver flower extracts are also used in health foods.

The form of use of the gold and silver flowers is not particularly limited.
It may be used as it is as a powder or as an extract. It is also possible to use a mixture of these.

[0010] The extraction solvent used in obtaining the extract is not particularly limited, as long as it is a solvent capable of suitably extracting the active ingredient of gold and silver flowers, such as a hydrophilic organic solvent such as water or alcohol, or a mixture thereof. Can be suitably used. In addition, as a hydrophilic organic solvent, monohydric alcohols, such as methanol and ethanol, polyhydric alcohols, acetone, etc. can be illustrated. Examples of the extraction method include a cold immersion method and a hot immersion method, but are not particularly limited.

The extract obtained by the above method may be used as it is, but it can be concentrated and used as a soft extract, or dried by freeze-drying or spray-drying and used as a dry extract.

Although the amount of the gold and silver flowers in the cosmetic composition is not particularly limited, the solid content (in the case of an extract, the solid content of the gold and silver flowers used for extraction) is 0.001 to 20% by weight based on the total composition. , More preferably 0.01 to 5% by weight.

[0013] The cosmetic composition having the above constitution has a moisturizing effect and an anti-tyrosinase activity, as is clear from the test examples described later. Therefore, the moisturizing effect gives the skin moisturizing and fresh skin can be maintained, and its anti-tyrosinase activity exerts an excellent whitening effect, so that pigmentation diseases such as spots, freckles, and black and white It can be used to suppress or treat skin and make fair and beautiful skin.

The dosage form of the cosmetic composition according to the present invention is not particularly limited, and in addition to ordinary cosmetics, its anti-tyrosinase activity is used to make it possible to use the sunburn to cause spots such as spots, freckles, and dark spots due to sunburn. It can be used as a medicated cosmetic (quasi-drug) having a specific purpose of use such as prevention of inflammation and recovery of skin after sunburn, and a drug for treating skin inflammation caused by sunburn. Specifically, lotion, cream,
It can be used as cosmetics such as emulsions, foundations, oily cosmetics, packs, skin cleansers and the like, and medicated cosmetics (quasi-drugs), ointments, liniments, lotions and the like.

In the present invention, in addition to the above-mentioned gold and silver flowers and / or extracts thereof, components which are blended in ordinary cosmetic compositions, such as oils, surfactants, ultraviolet absorbers, etc.
Pharmaceutical ingredients, alcohols, preservatives, dyes, fragrances and the like can be appropriately compounded within a range that does not impair the effects of the present invention.

[0016]

EXAMPLES Hereinafter, the present invention will be described based on Examples and Comparative Examples.
This will be described in detail. However, the present invention is not limited to these examples. (Examples 1-2) Honeysuckle (Lonicera japonica)
(T _HUNB .) _Was immersed in hot water at 60 ° C. for about 5 hours and filtered. After repeating this several times, the obtained hot water extracts were combined, concentrated under reduced pressure, and filtered again to obtain 1000 cc of a crude extract, which was used as a sample of Example 1. In addition, 100 g of the same gold and silver flowers
A sample of Example 2 was dispersed in cc of water.

(Examples 3 and 4) Honeysuckle (Lonicera ja
ponica T _HUNB .) flowers and buds and their related L.maa
The flowers and buds of ckii M _AXIM. were mixed, and 100 g of dried gold and silver flowers were immersed in warm water at 60 ° C. for about 5 hours and filtered. After repeating this several times, the obtained hot water extracts were combined, concentrated under reduced pressure, and filtered again to obtain a crude extract of 1000 cc.
Was obtained as a sample of Example 3. In addition, the same gold and silver flower 100
g was dispersed in 1000 cc of water to obtain a sample of Example 4.

(Comparative Examples 1 and 2) The standard product of glycerin was Comparative Example 1 and the standard product of arbutin was Comparative Example 2.

[0019]

Test Examples The following tests were performed using the samples of Examples 1 to 4 and Comparative Examples 1 and 2. (Test Example 1; Moisturizing Effect Test) Using the samples of Examples 1 to 4 and Comparative Example 1 as humectants, five kinds of lotions were prepared according to the following composition. Composition Blended amount (% by weight) Humectant 20.0 Ethanol 7.0 1,3-butylene glycol 6.0 Citric acid 0.2 Sodium citrate 0.8 Methyl parahydroxybenzoate 0.2 Ethyl paraoxybenzoate 0. 02 Appropriate amount of fragrance purified water Total remaining 100.0

Forty women with dry skin were panelists and divided into four groups of ten. Each of the four groups was a group using the lotion of Examples 1 to 4, and the left hand was applied twice a day in the morning and evening to the lotion for three weeks. In addition, the lotion of Comparative Example 1 was similarly applied to the right hand of all the panelists. Three weeks later, the degree of improvement of dry skin by using the lotion of Examples 1 to 4 was evaluated by comparing the left hand and the right hand with the following four grades. ◎: Dry skin is considerably improved compared to right hand ○: Dry skin is slightly improved compared to right hand △: Dry skin is hardly improved ×: Degree of dryness is worse

The results are shown in Table 1. The numbers in the table are
◎, ○, △, × are the corresponding numbers of persons.

[Table 1]

(Test Example 2; Moisturizing Effect Test) Using the samples of Examples 1 to 4 and Comparative Example 1 as humectants, five kinds of creams were prepared according to the following composition. Composition Blended amount (% by weight) Humectant 20.0 Ethanol 7.0 1,3-butylene glycol 6.0 Citric acid 0.2 Sodium citrate 0.8 Methyl parahydroxybenzoate 0.2 Ethyl paraoxybenzoate 0. 02 Appropriate amount of fragrance purified water Total remaining 100.0

Women with dry skin and rough skin 50
Names were panelists and divided into five groups of ten. The five groups were groups using the creams of Examples 1 to 4 and Comparative Example 1, respectively, twice in the morning and evening,
I had the cream applied to my face for three weeks. Three weeks later, the degree of improvement in skin roughness and moist feeling were evaluated on the following four scales. Skin roughening improvement effect ◎: considerably improved compared to before use ○: slightly improved compared to before use △: almost unchanged from before use ×: moist feeling worse than before use ◎ used Very moist compared to before ○: Slightly moist compared to before use △: Almost the same as before use ×: Deteriorated compared to before use

The results are shown in Table 2. The numbers in the table are
◎, ○, △, × are the corresponding numbers of persons.

[Table 2]

Test Example 3 Measurement of Anti-Tyrosinase Activity
B16 melanoma 4 cultured in 10% FBS-DMEM
A5 (RIKEN Cell Bank) in a 96-well plate, 5 × 10 ⁴ cells
s / well (total 195 μl), 37
Culturing was performed for 24 hours at 5 ° C. and 5% CO ₂ . Here, the sample solutions of Examples 1 to 4 and Comparative Example 2 were diluted with a 50% ethanol / PBS solution so as to have final concentrations of 5, 10, 50, 100, and 500 ppm, respectively.
5 μl each of which was sterilized by filtration through a 2 μm membrane filter was added, and the cells were further cultured under the same conditions for 24 hours. After the culture, the culture was removed and 1% Triton X-10 was removed.
After solubilizing the cell membrane with 50 μl of 0 / PBS solution, 100 μl of 10 mM L-DOPA was added as a substrate,
The reaction was performed at 37 ° C. for 3 hours, and the absorbance at a wavelength of 475 nm was measured using a microplate reader. Further, as a control, the absorbance of the reaction system in the case where the sample solution was not added was measured, and the tyrosinase biosynthesis inhibition rate (%) was calculated based on the following equation 1 (Equation 1).

(Equation 1) A: Absorbance without sample solution added B: Absorbance with sample solution added

The results are shown in Table 3.

[Table 3]

From the results of Tables 1 to 3, it can be seen that the cosmetic composition containing the gold or silver flower or its extract has a high moisturizing effect and also has an anti-tyrosinase activity. Therefore, the cosmetic composition according to the present invention can provide moisture to the skin with excellent moisturizing properties, exerts an excellent whitening effect due to anti-tyrosinase activity, and is effectively used as a cosmetic for whitening. It can also be used for suppressing or treating pigmentation diseases such as spots, freckles, and black and white.

Hereinafter, the formulation examples of the present invention are shown. (Formulation Example 1: Emulsion) Composition Blended amount (% by weight) Extract of Example 1 15.0 Squalane 5.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20E.O) 1 2.2 Propylene glycol 5.0 Ethanol 3.0 Carboxyvinyl polymer (1% aqueous solution) 18.0 Potassium hydroxide 0.1 Preservative 0.3 Perfume Fine purified water Remainder 100.0

[0029]

[0030]

As described in detail above, the invention according to claim 1 relates to a cosmetic composition characterized by containing gold and silver flowers and / or an extract thereof. , The gold and silver flowers are honeysuckle (Lonicera japonica T
_HUNB .) _And one or more of its closely related plants, which are dried flowers and / or buds of the plant. The effect of moisturizes the skin and makes the skin fresher, while exhibiting the whitening effect due to the anti-tyrosinase activity, it can be effectively used as a cosmetic for whitening. It has an excellent effect that it can be used for suppressing or treating pigmentation such as black.

Continued on front page F-term (reference) 4C083 AA111 AA112 AB032 AB052 AC012 AC022 AC072 AC102 AC122 AC182 AC302 AC312 AC402 AC442 AC612 AD092 AD112 CC05 CC07 EE06 EE07 EE16 FF01

Claims (2)

[Claims] 1. A cosmetic composition comprising gold and silver flowers and / or an extract thereof. 2. The method according to claim 1, wherein said gold and silver flowers are Lonicera ja
2. The cosmetic composition according to claim 1, wherein the flower and / or bud of at least one plant of Ponica T _HUNB .) and its closely related species are dried.