JPS61194008A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic having improved beautify effects capable of enhancing ability of liquid juice of sponge gourd to inhibit tyrosinase action and improving remarkably staining freckle, dark complexion, etc., obtained by using both the juice of sponge gourd and L-ascorbic acid or its ester. CONSTITUTION:A cosmetic using both juice of sponge gourd oozed from fruit of stems of sponge gourd (the juice has inhibitory effects on tyrosinase action to form melanin from tyrosine and one or more selected from a group consisting of vitamin C, namely, ascorbic acid and its ester in a weight ratio of 1:20-20:1. The amount of the juice of sponge gourd blended is >=0.0001wt% based on total amounts of external preparation for the sin effects.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a novel cosmetic with significantly improved whitening effect.

[Prior art] and [Problems to be solved by the invention] Cosmetics containing skin whitening agents are mainly used to whiten sunburned skin that causes spots and freckles. Of these, consumers are particularly interested.

Ascorbic acid inhibits the action of tyrosinase, which produces melanin from tyrosine, and also has the effect of converting the dark oxidized melanin that is being produced into light reduced melanin, resulting in whitening of the skin, age spots, freckles, and black skin. Although it is well known that it is an effective compound for treating and improving melasma, melasma, etc., it is extremely sensitive to heat and light and is easily oxidized, making it particularly difficult to use in cosmetics containing moisture. It is easy to decompose and cause discoloration. Therefore, in order to stabilize ascorbic acid, it has been proposed to blend ascorbic acid as an ester of higher fatty acids or phosphoric acid, or to add antioxidants or reducing agents. The more the product is used, the less the whitening effect becomes, and if the amount of the product is increased, skin irritation may occur.

[Means for solving the problem] In view of the above circumstances, the inventors of the present invention have conducted extensive research to obtain cosmetics with truly excellent whitening effects, and as a result, have found that:
Loofah sap has the ability to inhibit the action of tyrosinase, which produces melanin from tyrosine, and its inhibitory effect is enhanced when used in combination with L-ascorbic acid or its derivatives, resulting in noticeable age spots, freckles, and dark skin. The present inventors have discovered that this can be improved, and have completed the present invention.

That is, the present invention is a cosmetic material containing one or more selected from the group consisting of L-ascorbic acid and esters thereof, and loofah sap.

Hereinafter, the configuration of the present invention will be explained in detail.

Mono-ascorbic acid used in the present invention is generally referred to as vitamin C, and its strong reducing action promotes cellular respiration.
It has an enzyme activation effect, a collagen formation effect, and a melamine reduction effect. In addition, examples of L-ascorbic acid esters include L-ascorbic acid monostearate, L-ascorbic acid monostearate, and L-ascorbic acid monostearate.
- L-ascorbic acid monoalkyl esters such as ascorbic acid monopalmitate, L-ascorbic acid monooleate, L-ascorbic acid monophosphate, L
- Mono-ascorbic acid monoester conductors such as ascorbic acid-2-sulfuric acid, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate, etc. -ascorbic acid diester derivative,
Commercially available examples include trialkyl esters such as L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, and L-ascorbic acid triolate, and ascorbic acid triester derivatives such as L-ascorbic acid triphosphate. Ru.

In the cosmetics of the present invention, one or more selected from the group consisting of monoascorbic acid and its esters described above are appropriately selected and used.

L-ascorbic acid or L-ascorbic acid ester is effective when incorporated in cosmetics at 0.001% by weight or more, and in order to exhibit the effects of the present invention, 10% by weight is required.
It is enough.

The sap of loofah used in the present invention is the sap exuded from the fruit or stem of loofah of the family Cucurbitaceae, genus Luffa.

Loofah is an annual herb that is native to the tropics and cultivated in many places. In summer and autumn, yellow unisexual pores are opened.Male flowers are raceme and female flowers are simple. The fruit is long cylindrical and rich in reticular fibers. The sap obtained from loofah has been known as a natural lotion since the Edo period, and has a refreshing aroma and excellent water-retaining properties, helping to keep your skin smooth and clean.

The blending amount of the loofah sap of the present invention is 0.0000% of the total amount for external use on the skin.
If it is blended in an amount of 0,001% by weight or more, the effect will be enhanced.

The blending ratio of L-ascorbic acid or L-ascorbic acid ester and loofah extract is 1:20-2 by weight.
0:1 is preferred.

In addition to the above-mentioned essential ingredients, the skin external preparation of the present invention contains other ingredients that are usually used and blended in cosmetics, such as oil, 11
i! A lubricant, an ultraviolet absorber, an antioxidant, a surfactant, a preservative, a humectant, a fragrance, water, alcohol, a thickener, and the like can be added as appropriate.

Next, the present invention will be roughly explained in detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

The whitening effect is based on the so-called tyrosinase activity inhibition rate, which is the rate at which Dopa inhibits the action of tyrosinase, which produces the black-brown pigment melanin, and the skin whitening effect of cumulative application, and the results of usage tests such as the elimination of age spots and freckles. Judgment was made from two points.

Dopachrome, a melanin intermediate produced by using rosinase L-dopa as a substrate and acting on tyrosinase at 25° C. for 1.5 minutes, was measured using an absorptiometer at 475 nm. The reaction solution composition and determination method are shown below.

(Reaction liquid composition) L-dopa 0.5mg/ml
O,5Ill.

Phosphate buffer (pH6,8) 0.9
ml sample solution wf, 0.05yal Tyrosinase (pine mushroom) 0.05ml
(log/ml) (500unit/+sl)(
Judgment) 0: Tyrosinase inhibition rate 70 or more 0:
/J 5O-70XΔ
: n 20 = 50 pieces x 20 pieces or less (Test method) One group of 20 test subjects suffering from dark skin, spots, freckles, etc., applied the lotion in the morning and evening for 3 months. It was applied to the face every day, and its whitening effect was examined after 3 months.

(Judgment criteria) Author: Effect: Pigmentation is almost invisible.

Effective: Very tingling.

Slightly effective: Slightly tingling.

Ineffective: Judging as no change) 0: If the percentage of test subjects who are markedly effective or effective (effective rate) is 80 or more ○: If (effective rate) is 50-80 ×: ( If the efficacy rate) was 50z or less, the following herbal medicines were tested for inhibition of tyrosinase activity. In other words, extracts of carrot, ivy, and horse chestnut containing saponin as the main ingredient; extracts of Hamamelis, chamomile, and sawweed containing tannin as the main ingredient; extracts of Auronicum oleracea containing berberine as the main ingredient; and loofah sap. I followed him. As a result, it was found that extracts of loofah sap, hamamelis, chamomile, and yarrow showed a high inhibitory effect on tyrosinase activity. It was discovered that the tyrosinase activity inhibitory effect of loofah extract is enhanced when L-ascorbic acid is combined with loofah sap, loofah melis, and loofah melis, and the present invention has been completed.

Next, Example 1 and Comparative Examples 1 to 6 will be described.

A lotion having the composition shown in Table 1 was prepared, and its tyrosinase activity inhibiting effect and skin whitening effect upon cumulative application were investigated.

The manufacturing method was adjusted as follows. That is, 0.5 g of POE (20) lauryl ether to 10 g of 95% ethyl alcohol.
g and fragrance, and then add 2 g of glycerin, 1 g of propylene glycol, and 0 citric acid in advance.
．． Add 2 g of L-ascorbic acid or its ester and loofah juice, add distilled water to a colander until the total weight is 10
The required amount was added and mixed to adjust the amount to 0g.

(The following is a blank space) Table 1 Table 2 As is clear from Table 1, the cosmetic of the present invention is a novel cosmetic with excellent whitening effects.

Example 2 Emulsion A milky lotion was produced by a conventional method according to the following recipe.

Stearic acid 2.0 Cetanol 1.0 Vaseline
3゜0 lanolin alcohol
2.0 liquid paraffin
8.0 Squalane 3.
0 Esriki Roll 507 2.0 Ascorbic acid-2-sulfuric acid Ha 0.1 Loofah juice o,ooosPOE
(10 mol) Monooleate 2゜5 Triethanolamine 1.0 Propylene Glycol 5.0 Preservative
Appropriate amount of fragrance
Appropriate amount of distilled water Remaining Example 3 Nutritional Cream A nutritional cream was produced by a conventional method according to the following formulation.

Stearic acid 2.0 Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane
5.0 Octyldotecanol 6.0P, 0. E (25 mol) cetyl ether
3.0 Lipophilic Glytin Stearate
2.0 preservative
Appropriate amount of fragrance
Appropriate amount of propylene glycol
5.0゜Ascorbic acid talate ester
0.3 Ascorbic acid diolate 0.2 Luffa sap 3.0 Distilled water Remaining Example 4 Pack A pack was manufactured by a conventional method according to the following recipe.

Kaolin 69.6 Talc 19. O Propylene glycol 5.0 Calcium acetate 0.01 Urea
0.5 Ascorbic acid monopalmitate 5.0 Luffa liquid juice
0.5 fragrance
0.39 Example 5 Lotion A pack was manufactured by a conventional method according to the following formulation.

Ethanol 15.0P,
0. E (20 moles) oleic encore ether
0.82-hydroxy-4-methoxypentuphenone
0.1 citric acid
0.05 Sodium citrate
0.01L-ascorbic acid 0.
05 Loofah juice 0.05
Glycerin 5.0 Preservative Appropriate amount of fragrance
Appropriate amount of distilled water
The cosmetics obtained from the remaining Examples 2 to 5 had excellent tyrosinase activity inhibition effects and also excellent whitening effects when applied cumulatively.

Claims (1)

[Claims] A cosmetic comprising one or more selected from the group consisting of L-ascorbic acid and its esters and loofah sap.