JPH0436215A - Cosmetic having antiinflammatory property - Google Patents

Abstract

PURPOSE:To obtain a cosmetic excellent in antiinflammatory action on the skin with high persistence by adding specific ingredients such as epsilon-aminocaproic acid or glycyrrhizic acid to dishcloth gourd juice. CONSTITUTION:A cosmetic is obtained by blending at least one ingredient selected from epsilon-aminocaproic acid, glycyrrhizic acid and salts thereof, glycyrrhetinic acid ands salts thereof, allantoin, salicylic acid and salts thereof, bisabolol and tranexamic acid with dischloth gourd juice. The aforementioned cosmetic has excellent antiinflammatory effects with good persistence thereof. The dishcloth gourd juice is blended in an amount of preferably 3-99wt.%, especially 10-90wt.% based on the total amount of the cosmetic and the other ingredients are blended in an amount of preferably 0.005-5wt.%, especially 0.05-2wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a cosmetic that has a high anti-inflammatory effect and has an excellent long-lasting effect.

[Prior Art and Problems] Conventionally, allantoin, aloe extract, aloe powder, ictamol, guaiazulene, sodium guaiazulene sulfonate, glycyrrhizinic acid, and the like have been known as anti-inflammatory agents for the skin after sunburn. For example,
Publication No. 46892 describes that a cosmetic containing a Cucurbitaceae plant extract has an inflammatory effect on the skin. Furthermore, Japanese Patent Application Laid-open No. 179819/1983 states that loofah saponino prevents roughness and sagging of the skin and mucous membranes, and has a therapeutic effect on wounds and skin damage. However, although all of these drugs have a temporary anti-inflammatory effect, they have poor sustainability, and a sufficient anti-inflammatory effect cannot be obtained.

An object of the present invention is to provide a cosmetic that has excellent anti-inflammatory effects on the skin and has a long-lasting effect.

[Means for Solving the Problems] From this point of view, the present inventors have made extensive studies in order to obtain cosmetics with excellent anti-inflammatory effects, and have found that loofah water contains ε-aminocaproic acid and glycyrrhizic acid. The present invention was completed based on the knowledge that adding a specific component enhances the effect of reducing the erythema that appears on the skin when exposed to a certain amount of ultraviolet rays.

That is, the present invention provides loofah water, ε-aminocaproic acid, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, Alandeutschland, salicylic acid and its salts,
The present invention provides a cosmetic containing pizzaphorol and at least one anti-inflammatory agent selected from tranexamic acid.

"Luffa" used in the present invention is Luffa cyl of Cucurbitaceae.
indrica Roem. The loofah water used in the present invention is sap exuded from the fruit or stem of loofah, and can be collected by a known method.

If the collected loofah water is left as it is, it will rot and the growth of bacteria will occur. For this purpose, the collected loofah water contains ethanol, paraoxybenzoic acid ester or its salt, benzoic acid or its salt, salicylic acid or its salt, sorbic acid or its salt, dehydroacetic acid or its salt, isopropylmethylphenol, orthophenylphenol, cresol, It is desirable to add a preservative such as phenoquine ethanol as appropriate.

The amount of loofah water blended is 3 to 99% by weight, preferably 5 to 95% by weight, and more preferably 10 to 90% by weight based on the total amount of the cosmetic.

If the blending amount of loofah water is less than 3%, the anti-inflammatory effect will not be sufficiently expressed, while if it exceeds 99%, the storage stability of loofah water will decrease, which is not preferable.

Ingredients used with loofah water in the cosmetics of the present invention include salts of glycyrrhetinic acid and its esters such as ε-aminocaproic acid, glycyrrhizic acid and its potassium salt, salts of allantoin, salicylic acid and its salts, hizafolol, and tranexamic acid. Can be mentioned.

These may be used alone or in combination. The blending amount of these ingredients is 0005 to 5% by weight based on the total amount of cosmetics.
, preferably 0.05 to 2% by weight.

If the amount of such ingredients is less than this, a sufficient anti-inflammatory effect against skin inflammation will not be exhibited, and if it exceeds the upper limit, a cosmetic with a preferable feeling of use will not be obtained.

Next, the anti-inflammatory properties of the cosmetics of the present invention were tested using cosmetics having the compositions shown in Table 1. Using the solutions of Test Nos. 1 to 9, an erythema suppression test against ultraviolet irradiation of the large back was conducted. Test: Approximately 0% of each sample was used using 10 adult males.
After irradiating 1 mQ for 5 minutes from a distance of 50 cm using an ultraviolet light generator with a wavelength of 300 to 380 nm, the test was applied immediately, and the degree of erythema was compared after 6 hours. The degree of stimulation was quantified as follows.

0 Same as non-irradiated area slightly erythematous Erythema less severe than 23 3.Clear erythema 4. Erythema slightly easter than the unapplied area 5 Same as uncoated area The results are also shown in Table 1.

From the above results, compared to when the anti-inflammatory agent used in the study was used alone and when loofah water was used alone, when both were used in combination, the suppressive effect on erythema was clearly enhanced.

From these results, it was found that although sufficient anti-inflammatory effects were not obtained when the anti-inflammatory agent was used alone, a significant anti-inflammatory effect was obtained when used together with loofah water. Furthermore, by adding loofah water, a non-irritating cosmetic can be obtained.

The anti-inflammatory cosmetics of the present invention can be prepared by known methods such as creams, milky lotions, lotions, aftershave brow methane,
It is prepared into various types of skin cosmetics, including hair tonics, makeup products, foundations, and essences for the head.

Furthermore, the cosmetic composition of the present invention may contain any known components as appropriate, depending on the type thereof, within a range that does not impair performance. That is, in addition to the above-mentioned essential ingredients, the cosmetic of the present invention contains ingredients normally used and blended in cosmetics, such as oil, ultraviolet absorbers, antioxidants, surfactants, preservatives, fragrances, water, Alcohol, thickener, pigment, etc. can be added as appropriate.

[Example] Next, the present invention will be explained in more detail based on an example. In the examples, the amounts are expressed in weight%.

Example 1 (cream) Ingredients Amount Stearic acid 2.0 Cetanol
5.0 beeswax
2.0 liquid paraffin
5.0 glyceryl trioctanoate 50 polyoxyethylene (20
E, O,) Cetyl ether 20 Self-emulsifying glycerin monostearate 30 Methyl paraoquinobenzoate OI Ethyl paraoquinobenzoate 0.3 Fragrance
0.2 propylene glycol
50 Loofah water Potassium glycyrrhetinic acid Potassium hydroxide ε-Aminocaproic acid Purified water meter Remaining Example 2 (Emulsion) Ingredients Setanol stearate Vaseline Beeswax squalane Glycyrrhetinic acid stearyl Monostearate Polyoquine Ethylene sorbitan (20E, O,) Triethanolamine Propylene glycol fragrance compounding amount 1.5 0.8 Loofah water Rosewood methyl beanzoate ethanol Purified water meter Example 3 (lotion) Ingredients Polyochinoedyleno hydrogenated cypress oil Ethanol Fragrance Loofah water Glycyrrhizinate monopotassium d1 ~ Pyrrolidone carvone Acid Sodium Citrate Sodium Citric Acid Purified Water Meter Remaining Blend Amount Remaining! 00 Example 4 (Afternoe Brow Noyore) Ingredients Polyoxyethylene Hydrogenated Himano Oil (60E, O,) Ethanol Fragrance Loofah Water Allantoinsalicylic Acid Sodium Citrate Purified Water Meter Example 5 (Hair Tonic) Ingredients Polyoxyethylene (20E , O,) Cetyl ether ethanol fragrance hydrochloride pyridoquinone salicylic acid Blending amount 0.7 0.3 30.0 0.2 0.2 0.1 Remaining blending amount 1.0 55.0 0.7 I O,1 Loofah Water dl-Sodium pyrrolidonecarboxylate Benzyl nicotinic acid Dipotassium glycyrrhizate Purified water meter Example 6 (foundation) Ingredients Squalane Liquid paraffin Solid paraffin Olive oil Stearic acid Lipophilic monostearate Glycerin Monostearate Polyoquine Ethylene sorbitan (20E, O,) Triethanolamine propylene glycol α-visaporol 0.005 0.3 Remaining amount 4.0 2.0 2.0 2.5 1.5 5.0 Methyl paraoxybenzoate Fragrance Titanium oxide Black Iron oxide Yellow oxide Iron loofah water Carboquine vinyl polymer Purified water Total 0.2 0.2 7.5 0.05 Balance polyochinoethylene (60E Hardened cypress oil fragrance Tranexamic acid Purified water Total balance +00 [Effects of the invention 2 Cosmetics of the present invention has excellent anti-inflammatory effects on the skin and its effects are long-lasting.

Example 7 (Essence) Component loofah water sodium citrate Hydroxyethyl cellulose sodium xanthan gum glycerin ethanol Methyl paraoxybenzoate

Claims (1)

[Claims] (1) Loofah water: ε-aminocaproic acid, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts,
A cosmetic having anti-inflammatory properties, containing at least one component selected from allantoin, salicylic acid and its salts, bizabolol, and tranexamic acid.