JPS63179819A - Skin external preparation containing luffe cylindrica essence for peripheral part of anus - Google Patents
Skin external preparation containing luffe cylindrica essence for peripheral part of anusInfo
- Publication number
- JPS63179819A JPS63179819A JP62011898A JP1189887A JPS63179819A JP S63179819 A JPS63179819 A JP S63179819A JP 62011898 A JP62011898 A JP 62011898A JP 1189887 A JP1189887 A JP 1189887A JP S63179819 A JPS63179819 A JP S63179819A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- luffe
- cylindrica
- external preparation
- anus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000436 anus Anatomy 0.000 title claims abstract description 6
- 230000002093 peripheral effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 claims abstract description 13
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 9
- 229930182490 saponin Natural products 0.000 claims abstract description 9
- 150000007949 saponins Chemical class 0.000 claims abstract description 9
- 150000008505 β-D-glucopyranosides Chemical class 0.000 claims abstract description 9
- 229930182494 ginsenoside Natural products 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract 4
- 239000008103 glucose Substances 0.000 claims abstract 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims abstract 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims abstract 2
- 244000280244 Luffa acutangula Species 0.000 claims description 24
- 235000009814 Luffa aegyptiaca Nutrition 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 210000004877 mucosa Anatomy 0.000 abstract 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 229920000742 Cotton Polymers 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 7
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 5
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 208000014617 hemorrhoid Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010037844 rash Diseases 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000001217 buttock Anatomy 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010898 silica gel chromatography Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- YAHHFDSODKFKOV-OTEWLTGOSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;(2r,3r,4s,5s)-2,3,4,5-tetrahydroxyhexanal Chemical group C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O YAHHFDSODKFKOV-OTEWLTGOSA-N 0.000 description 1
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 235000003956 Luffa Nutrition 0.000 description 1
- 241000219138 Luffa Species 0.000 description 1
- 241000277269 Oncorhynchus masou Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000013305 flexible fiber Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 description 1
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 description 1
- 229960004135 idebenone Drugs 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
肛門周辺部の洗浄の方法として、最近洋式便器に温水器
を取付けて、その温水を噴射して洗浄する方法が増えつ
つありこの方法は好ましい方ではあるが、現在の所は洋
式便器のみに取り付けられておリ、又価格が高くつき或
は外出した場合は実施出来ない等の問題がある。[Detailed Description of the Invention] Recently, as a method of cleaning the area around the anus, a method of attaching a water heater to a Western-style toilet bowl and spraying hot water to cleanse the area has been increasing.Although this method is preferable, the current There are other problems, such as being attached only to Western-style toilet bowls, being expensive, or not being able to be used when going out.
その為、一般的には従来通りのトイレットペーパーを使
用して清浄する方法が、専ら行なわれている。Therefore, the conventional method of cleaning using toilet paper is generally used exclusively.
トイレットペーパーは最近品質が非常に改善されて多種
類のものが市販されているが、ペーパーである為どうし
ても物理的な硬さは避けられず、十分に揉んで使用して
も尚拭き取りが完全でなく或は十分拭き取ろうとして反
って皮膚に微細な擦傷を生じ、痔疾患者にとっては苦痛
を伴うものであると共に症状が悪化する因にもなってい
る。Recently, the quality of toilet paper has greatly improved and there are many types on the market, but since it is paper, it is unavoidable that it is physically hard, and even if it is thoroughly rubbed and used, it still cannot be wiped completely. If the hemorrhoids are not properly wiped off, the hemorrhoids warp and cause minute scratches on the skin, which is painful for people suffering from hemorrhoids and also causes their symptoms to worsen.
又、皮膚の弱い赤ちゃんや寝たきり老人が、排便後の処
理不十分の為、肛門周辺部や臀部等に、膚荒れを生じた
り、おむつ被れを生じたりする恐れがある。In addition, babies and bedridden elderly people with sensitive skin may develop rough skin in the anal area, buttocks, etc., or diaper rashes due to inadequate post-defecation treatment.
又、女性用生理綿は広く女性に用いられている。In addition, sanitary cotton for women is widely used by women.
最近はより小型で良く体に密着し見掛６プの体型を損う
事なく着用感の優れたものが要求されている。Recently, there has been a demand for something that is smaller, fits better to the body, and is comfortable to wear without detracting from the apparent six-piece figure.
これが為多くの血液を吸収し、吸収後はシェリー状に固
まり、洩れを防ぐ高吸血液性の樹脂を配合したり、又よ
り柔軟性のある繊維や接着剤の使用を最大限に押えた不
綿布を使用したりしている。For this reason, it absorbs a lot of blood, and after absorption, it hardens into a sherry-like consistency, and is formulated with highly blood-absorbing resin that prevents leakage, as well as a nonwoven fabric that minimizes the use of more flexible fibers and adhesives. I also use cotton cloth.
しかし、小型で体によく密着したものに設計されればさ
れる程、皮膚や粘膜との摩擦を増し「ただれ」や「かぶ
れ」「びらん」等の皮膚のトラブルを生じている。However, as devices are designed to be smaller and fit closer to the body, they increase friction with the skin and mucous membranes, causing skin problems such as sores, rashes, and sores.
本発明はかかる問題を解決する為に、ヘチマエキスを含
む肛門周辺部の皮膚外用剤組成物を、提供することにあ
る。我々は、これに対し種々検討した結果、ヘチマエキ
ス又は、上記ヘチマサポニン物質を使用する事により、
これらのトラブルを解消する事の出来る事を見出した。In order to solve this problem, the present invention provides a composition for external use on the skin around the anus, which contains loofah extract. As a result of various studies, we found that by using loofah extract or the above-mentioned loofah saponin substance,
We have discovered something that can solve these problems.
ここで用いられるヘチマとしては、達磨種、長糸瓜種、
ｌ−カドヘチマ等があり、抽出に供される部位とし
ては、果実、基１葉、つる等すべてが可能であるが、特
に果実（種子を含む）が、ヘチマサボニン物質の含有量
が多いので好ましい。The loofahs used here include Daruma type, Long Silk Melon type,
There are l-Cad loofah, etc., and all parts such as fruits, basal leaves, and vines can be extracted, but fruits (including seeds) are particularly preferred because they have a high content of luffa sabonin substances.
このようなヘチマを原料として使用して、ヘチマエキス
を製造する方法としては、その−製造例を示す。ますｎ
−ヘキサン等の脱脂溶剤で、原料のヘチマ粉末を脱脂後
、低級アルコールで加熱抽出し、次いでこの抽出液を減
圧蒸溜して溶剤を留去乾燥すれば、ヘチマエキスが得ら
れる。A production example of a method for producing a loofah extract using such a loofah as a raw material will be shown below. Masu n
- A loofah extract can be obtained by defatting the raw material loofah powder with a degreasing solvent such as hexane, then heating and extracting it with a lower alcohol, and then distilling this extract under reduced pressure to remove the solvent and drying it.
抽出溶剤及び、溶剤として用いられる低級アルコールと
しては、メタノール、イソプロパツール。Examples of extraction solvents and lower alcohols used as solvents include methanol and isopropanol.
イソブタノール、 ｒｌ−ブタノール等の低級アルコ
ール、同アルコールの含水物が同じく使用可能であり、
又液圧乾燥力の代りにカラムクロマト吸着明細書の浄書
（内容に変更なし）
精製法を採用する抽出法であってもよい。Lower alcohols such as isobutanol and rl-butanol, and hydrated versions of the same alcohols can also be used,
Alternatively, an extraction method that employs a column chromatographic adsorption specification purification method (no change in content) may be used instead of hydraulic drying power.
このヘチマサボニンをメタノールに溶解し、シリカゲル
、カラムクロマトで精製分別し、Ｈ−ＮＭＲプロトン（
核磁気共鳴）、赤外線吸収スペクトル（ＩＲ）、紫外線
吸収スペクトル（ＵＶ）ｌ及び元素分析、更には１３Ｃ
−ＮＭＲ等で構造決定したところ一般式（ＩＩＩ） （
ＩＶ ）で表わされるサポニン物質が含まれている事が
、判明した。This loofah sabonin was dissolved in methanol, purified and fractionated using silica gel and column chromatography, and H-NMR proton (
nuclear magnetic resonance), infrared absorption spectrum (IR), ultraviolet absorption spectrum (UV) and elemental analysis, as well as 13C
-The structure was determined by NMR etc. and the general formula (III) (
It was found that it contained a saponin substance represented by IV).
［ＩＩＩ ］ ギンゼノサイド類明細書の浄
書（内容に変更なし）
ギンゼノサイドＲｅ：Ｒ＝グルコースーラムノースギン
ゼノサイドＦｔｇｌ：Ｒ＝ニブルコース ＩＶ ］
ルシオサイド 類明細書の浄書（内容に変更なし
）
ルシオサイドＡ： Ｒ１＝ＣＨ２０Ｈ％Ｒ２＝β−Ｄ−
グルコピラノシド、Ｒ３＝ＯＨ，Ｉ’ｔ４＝Ｈルシオサ
イドＢ ： Ｆｔ、＝ＣＨ２０Ｈ，Ｊ＝β−Ｄ−グルコ
ピラノシド、Ｒ３＝Ｈ，ＦＬ４＝ＯＨルシオサイドＣ：
Ｒ，＝ＣＨ３、Ｒ２＝β−Ｄ−グルコピラノシド：
Ｒｓ”ＯＨ，Ｒ４＝ＨルシオサイドＤ ： Ｒ１＝ Ｃ
ＨＯ％Ｒ２＝β−Ｄ−グルコピラノシド、Ｒ３＝Ｈ，Ｒ
４＝ＯＨルシオサイドＥ ： Ｒ１＝ＣＨ２０Ｈ％ Ｒ
２＝β−Ｄ−グルコピラノシド、Ｒ３＝Ｈ，Ｒ４＝Ｈル
シオサイドＦ ： Ｒ１＝ＣＨ０，Ｒ２＝β−り一グル
コピラノシド、Ｒ３＝Ｈ，Ｒ４＝ＨルシオサイドＧ ：
Ｒ，＝ＣＨ３、Ｒ２＝β−Ｄ−グルコピラノシド’
Ｒ３＝ Ｈｓ Ｒ４＝ ＯＨルシオサイドＨ： Ｒ１＝
ＣＨ３、Ｒ２＝β−Ｄ−グルコピラノシド： Ｉ’ｔ３
＝Ｈ，Ｒ４＝ＨルシオサイドＩ：Ｒ，＝ＣＨ２０Ｈ，Ｒ
２＝Ｈ，Ｒ３＝Ｈ，Ｒ４＝ＯＨ上記抽出法により抽出単
離されたヘチマエキス、又は上記サポニン物質を含む薬
剤を肛門周辺部の処置に用い、優れた予防・治療効果が
表われる事を見出し、本発明を完成した。即ち、清掃作
用を有するのみでなく、皮膚、粘膜の荒れ・ただれを防
ぐと共に創傷や皮膚の損傷等に対し優れた治療効果があ
った。又、健全で美しい肌作りにも効果がある事も見出
された。これは、ヘチマエキス及び上記サポニン物質が
血行促進、細胞賦活に効果あり、其の総合効果として表
われたものである。[III] Copying of specification of ginsenosides (no change in content) ginsenoside Re:R = glucose-rhamnose ginsenoside Ftgl:R = nibblecose IV]
Lucioside Engraving of related specifications (no changes in content) Lucioside A: R1=CH20H%R2=β-D-
Glucopyranoside, R3=OH, I't4=H Lucioside B: Ft, =CH20H, J=β-D-glucopyranoside, R3=H, FL4=OH Lucioside C:
R,=CH3, R2=β-D-glucopyranoside:
Rs”OH, R4=H Lucioside D: R1= C
HO%R2=β-D-glucopyranoside, R3=H,R
4=OH Lucioside E: R1=CH20H% R
2=β-D-glucopyranoside, R3=H, R4=H lucioside F: R1=CH0, R2=β-ri-glucopyranoside, R3=H, R4=H lucioside G:
R,=CH3, R2=β-D-glucopyranoside'
R3= Hs R4= OH Lucioside H: R1=
CH3, R2=β-D-glucopyranoside: I't3
=H, R4=H Lucioside I:R, =CH20H,R
2=H, R3=H, R4=OH It is expected that the loofah extract extracted and isolated by the above extraction method or the drug containing the above saponin substance will have excellent preventive and therapeutic effects when used for the treatment of the perianal area. The present invention has been completed. That is, it not only has a cleaning effect, but also prevents roughness and sores on the skin and mucous membranes, and has an excellent therapeutic effect on wounds and skin damage. It was also found to be effective in creating healthy and beautiful skin. This is because loofah extract and the above-mentioned saponin substances are effective in promoting blood circulation and activating cells, and are expressed as a comprehensive effect.
本発明は上記のヘチマエキスを水溶液、水分散液、又は
有機溶剤の形にして使用できる。In the present invention, the above loofah extract can be used in the form of an aqueous solution, an aqueous dispersion, or an organic solvent.
又、使用形式に応じて適宜な濃度に調整して使用する事
が出来るが、好ましくは処理液中にヘチマエキス及び上
記サポニン物質が０．００５〜０．５％含まれる事によ
り優れた効果が得られる。In addition, the concentration can be adjusted to an appropriate concentration depending on the type of use, but it is preferable that the treatment liquid contains 0.005 to 0.5% of the loofah extract and the saponin substance to achieve excellent effects. can get.
本発明品は、前記の必須成分に加え必要に応じ化粧品、
医薬品等に一般に用いられている油分。In addition to the above-mentioned essential ingredients, the product of the present invention can also be used as a cosmetic product if necessary.
Oil commonly used in pharmaceuticals, etc.
界面活性剤、保湿剤、酸化防止剤、殺菌剤、消炎剤等の
薬効剤、香料など本発明品の効果を損わない範囲で配合
する事が出来る。本発明品の使用する方法としては、適
当な容器に充填して使用し、特にスプレー形式で使用す
る事が便利である。Medicinal agents such as surfactants, humectants, antioxidants, bactericides, and anti-inflammatory agents, and fragrances can be added within the range that does not impair the effects of the product of the present invention. The method of using the product of the present invention is to fill it into a suitable container, and it is especially convenient to use it in a spray format.
或は、トイレットペーパー、ティシュペーパー又は、精
製脱脂綿等に含浸せしめて湿潤状態又は乾燥状態にて使
用する事が出来る。Alternatively, it can be used in a wet or dry state by impregnating toilet paper, tissue paper, purified absorbent cotton, or the like.
又、携帯に便利な形式を選ぶ事も出来る。You can also choose a format that is convenient for mobile devices.
本発明品は、肛門部周辺に用いられるのみでなく一般の
皮膚・粘膜のトラブルの予防・治療にも用いる事が出来
る。The product of the present invention can be used not only for the anal area, but also for the prevention and treatment of general skin and mucous membrane problems.
以下、発明の詳細を実施例により説明する。Hereinafter, the details of the invention will be explained with reference to Examples.
［ヘチマエキスの製造 ］
ヘチマの菓及び茎を乾燥し含水率１％以下の物を粉砕、
其の粉末１００ｇを採取、ｎ−へキサン約１ ｋｇで２
回に別は洗′ａ脱脂後、イソプロピルアルコール約１ｋ
ｇ加え、６ｏ０ｃで約２時間加熱抽出を行い、次いでこ
の抽出液を０．ＩＴｏｒｒの真空下で加熱乾燥する。約
２．５ｇの残留物を得た。[Manufacture of loofah extract] Dry the loofah confections and stems and crush the ones with a moisture content of 1% or less,
Collect 100g of the powder, and use about 1kg of n-hexane to make 2
After cleaning and degreasing, approximately 1k of isopropyl alcohol is used each time.
g was added and extracted by heating at 6o0c for about 2 hours, and then this extract was heated to 0.0g. Heat and dry under a vacuum of ITorr. Approximately 2.5 g of residue was obtained.
一方、此のヘチマエキスをメタノールに溶解し、シリカ
ゲルカラムクロマトで精製分別し、核磁気共鳴、赤外線
スペクトル、紫外線吸収スペクトル及び元素分析更に”
Ｃ−ＮＭＲ等で構造決定した所前記の一般式［ｍ ］
［ＩＶ ］で表われるサポニンを含有していた。Meanwhile, this loofah extract was dissolved in methanol, purified and fractionated using silica gel column chromatography, and subjected to nuclear magnetic resonance, infrared spectrum, ultraviolet absorption spectrum, and elemental analysis.
The structure determined by C-NMR etc. is the general formula [m]
It contained saponin represented by [IV].
［実施例１．２．３． コ
前記のヘチマエキスを用い以下の処決により清浄剤を作
成した。[Example 1.2.3. A cleaning agent was prepared using the loofah extract described above and according to the following procedure.
１） 水溶液状
３） 油状
［試験法 ］
］） 試験 Ｉ
ラットの臀部の毛をそり剃刀で２ケ所に２．５ｃｍの切
傷をつけ実施例１．２．３．対照例１．２゜３、に示さ
れた清浄液を１日に２回塗り付け１週間後に肉の盛り上
ってきたところで、強い力を加えて引張ると実施例１．
２．３．の清浄液を塗布した方は非常につき具合が良く
、強い力に耐え得た。傷ついた部位の皮膚細胞を賦活し
、皮膚組織の再生を早めていた。1) Aqueous solution 3) Oil [Test method] ]) Test I The hair on the buttocks of a rat was shaved and two 2.5 cm incisions were made with a razor in Example 1.2.3. The cleaning solution shown in Control Example 1.2.3 was applied twice a day, and after one week, when the meat began to bulge out, strong force was applied to pull it.
2.3. Those who applied the cleaning solution had excellent adhesion and were able to withstand strong force. It activated skin cells in injured areas and accelerated the regeneration of skin tissue.
２） 試験 ＴＩ
発汗や水による漏れなどがない通常の状態で次の基準を
基にして皮疹の観察を行った。2) Test TI Skin eruptions were observed based on the following criteria under normal conditions without sweating or water leakage.
が認められる。is recognized.
＋：白くかさつきが見られる程肌荒れ ２が認
められる。+: Skin roughness 2 is observed to the extent that white and flaky appearance is observed.
二 二微かに肌荒れが認められる。 １−
：肌荒れが認められない。 ０健康
な多数の男子の前腕側部に実施例１．．２．３゜対照例
１．２．３．の清浄液を１日２回、３日間塗布した。塗
布し始めてから４日後下記方法で肌荒れを形成させ、其
の後に皮疹の観察を行い統計的処理を行った。数値の小
さい方が状態が良好である事を示している。2.2 Slight roughness of the skin is observed. 1-
: No rough skin observed. Example 1.0 on the side of the forearm of a number of healthy men. ．． 2.3° Control Example 1.2.3. The cleaning solution was applied twice a day for 3 days. Four days after the start of application, rough skin was formed using the method described below, and the eruptions were then observed and subjected to statistical analysis. The smaller the number, the better the condition.
肌荒れ形成法
方法 １）
アセトン、エーテル混合溶液（比率１：１）を被験部分
に固定した半径１．５ｃｍのカップに注ぎ１５分間脱脂
を行い、この操作を３回繰り返し、其の後エタノールと
水で洗浄する。Rough skin formation method 1) Pour acetone and ether mixed solution (ratio 1:1) into a cup with a radius of 1.5 cm fixed on the test area, degrease for 15 minutes, repeat this operation 3 times, and then add ethanol and water. Wash with
方法 ２）
界面活性法 １０％ドデシル硫酸ナトリウムを、被
験部分に固定した半径１．５ｃｍのカップに注ぎ、３０
分間撹拌しながら皮膚の脂質及び水溶性成分を抽出する
。Method 2) Surfactant method Pour 10% sodium dodecyl sulfate into a cup with a radius of 1.5 cm fixed on the test area, and
Extract lipids and water-soluble components of the skin while stirring for minutes.
［実施例４．５．コ
上記の方法で得られたヘチマエキス１ｇをイソプロパツ
ール５００ ｇに溶解生理綿で体に接する面に対し２ｇ
をスプレーし乾燥したもの［実施例４］、又上記の方法
で得られたルシオサイドＥを使用した以外は［実施例４
］と同じ様に作成した生理綿を［実施例５］とし、［実
施例４］［実施例５］においてヘチマエキスを含有せし
めるに用いた生理綿［対照例コを作成した。[Example 4.5. Dissolve 1 g of loofah extract obtained in the above method in 500 g of isopropanol. Apply 2 g to the side of sanitary cotton that comes in contact with the body.
was sprayed and dried [Example 4], and [Example 4] except that Lucioside E obtained by the above method was used.
] The sanitary cotton prepared in the same manner as [Example 5] was used as the sanitary cotton used to contain loofah extract in [Example 4] and [Example 5] [A control example] was prepared.
生理綿着用時「ただれ」「びらん」「あれ」に悩む被試
験者各２０名に対し［実施例４コ［実施例５コ［対照例
コにて作成した生理綿を５時間着用試験を行い皮膚、粘
膜のトラブル状態を観察した。Twenty test subjects who suffered from "sores,""sores," and "that" when wearing sanitary cotton were tested by wearing the sanitary cotton prepared in Example 4, Example 5, and Control Example for 5 hours. We observed problems with the skin and mucous membranes.
手続補正書 昭和６２年４月２４日 補正をする者Procedural amendment April 24, 1986 person who makes corrections
Claims (1)
抽出された物質を含む肛門周辺部の皮膚外用薬２）ヘチ
マから抽出、単離された下記に示す一般式［ I ］及び
［II］で表わされるヘチマサポニン物質の中から選ばれ
た１種、又は２種以上のヘチマサポニン物質を含有する
前記第（１）項の肛門周辺部の皮膚外用薬 ［ I ］ギンゼノサイド類 ▲数式、化学式、表等があります▼ （式中Ｒ：グルコース又はグルコースラムノース）［I
I］ルシオサイド類 ▲数式、化学式、表等があります▼ （式中Ｒ＿１＝ＣＨ＿３、ＣＨ＿２ＯＨ、ＣＨＯＲ＿２
＝Ｈ、β−Ｄ−グルコピラノシド Ｒ＿３＝Ｈ、ＯＨ Ｒ＿４＝Ｈ、ＯＨである。）[Scope of Claims] 1) A drug for external use on the skin around the anus containing a substance extracted from loofah (Luffe cylindrica) 2) A drug with the following general formulas [I] and [II] extracted and isolated from loofah (Luffe cylindrica) External drug for skin around the anus according to item (1) above containing one or more loofah saponin substances selected from the loofah saponin substances represented above [I] Ginsenosides ▲ Mathematical formula, chemical formula, table etc. ▼ (R in the formula: glucose or glucose rhamnose) [I
I] Luciosides▲There are mathematical formulas, chemical formulas, tables, etc.▼ (In the formula, R_1=CH_3, CH_2OH, CHOR_2
=H, β-D-glucopyranoside R_3=H, OH R_4=H, OH. )
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62011898A JPS63179819A (en) | 1987-01-21 | 1987-01-21 | Skin external preparation containing luffe cylindrica essence for peripheral part of anus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62011898A JPS63179819A (en) | 1987-01-21 | 1987-01-21 | Skin external preparation containing luffe cylindrica essence for peripheral part of anus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63179819A true JPS63179819A (en) | 1988-07-23 |
Family
ID=11790548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62011898A Pending JPS63179819A (en) | 1987-01-21 | 1987-01-21 | Skin external preparation containing luffe cylindrica essence for peripheral part of anus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63179819A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0429919A (en) * | 1990-05-25 | 1992-01-31 | Sunstar Inc | Moisture-retaining cosmetic |
| JPH0436215A (en) * | 1990-05-29 | 1992-02-06 | Sunstar Inc | Cosmetic having antiinflammatory property |
| JP2002138028A (en) * | 2000-10-30 | 2002-05-14 | Pias Arise Kk | Skin care preparation for external use and method for preparing the same |
-
1987
- 1987-01-21 JP JP62011898A patent/JPS63179819A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0429919A (en) * | 1990-05-25 | 1992-01-31 | Sunstar Inc | Moisture-retaining cosmetic |
| JPH0436215A (en) * | 1990-05-29 | 1992-02-06 | Sunstar Inc | Cosmetic having antiinflammatory property |
| JP2002138028A (en) * | 2000-10-30 | 2002-05-14 | Pias Arise Kk | Skin care preparation for external use and method for preparing the same |
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