JP3460904B2 - External preparation for skin - Google Patents

Description

Description: BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention
Prevents aging of the skin and smooth and moist skin
Skin creams and cosmetics to give
And useful skin external preparations. [0002] Conventionally, "Shi"
Wawa is also one of the skin cosmetic problems,
It is known to worsen by the effects of drying and ultraviolet rays
You. The mechanism of this "wrinkle" is still unknown
There are many, but at the epidermis level of the skin dryness and moisturizing power of the stratum corneum
Decrease at the dermis level, and long-term skin aging
UV irradiation affects the denaturation of elastic fibers,
It is thought that the elasticity decreases due to the collapse of the chin net.
Have been. [0003] In recent years, this "wrinkle" and other skin
Many cosmetics that prevent aging are known, and their active ingredients
Retinoic acid, α-hydroxy acid, retinol (bi
Tamine A) and the like have been reported. However, these
Active ingredients have problems in skin irritation, stability, etc., and
The effect was not enough. [0004] Therefore, there is no such problem, and skin cells
Has activation, promotion of metabolism, wound healing effect, etc.
Coenzyme A [C21H36N7]
O16P3S, coenzyme A, hereinafter simply referred to as "CoA"]
And its salts have been developed (JP-A-50-31051).
Gazette). In addition, this CoA and / or a salt thereof
It is unstable, and if these are blended in cosmetics, color tone will deteriorate
Investigate its stabilization because it will adversely affect other components of
Oxidation synthesized by oxidation reaction of CoA and / or its salt
Type CoA shows high stability in the formulation,
It has the effect of improving fine lines, wrinkles and skin texture.
(Japanese Patent Application Laid-Open No. 2-49729 of the present applicant)
No.). [0005] On the other hand, seaweed extracts generally have a moisturizing effect.
It is known to be used in many cosmetics. That
The effect is to promote the synthesis of biological hyaluronic acid contained in the extract
Activates skin cells' ability to synthesize hyaluronic acid
Improves skin moisturizing, softness and elasticity and improves skin aging
It is considered to show the effect of preventing the formation of a gas. Already green algae
Of the Ulva family Aulana, Ulva family Aonori, and red algae
Gastropodaceae Ogonori, Atenaceae Maxa, Milinaceae
Linsai, and brown alga Laminaria, Alaine, Ainu
Wakameidae Wakame, Honewaraceae Hijiki, Hibamata
Seaweed extraction belonging to Ascophyllum, Funori family Funori
Has been found to promote hyaluronic acid synthesis (see
JP-A-6-9422 and JP-A-7-10 of the applicants
1871, Japanese Patent Application No. 7-9605). These seas
Algae extract shows anti-aging effect on skin,
An external preparation for skin having an even better anti-aging effect on the skin
The development of is desired. SUMMARY OF THE INVENTION The present invention relates to a conventional Co
A: Anti-aging effect of skin even better than seaweed extract
An object of the present invention is to provide an external preparation for skin having Means for Solving the Problems [0007] The present inventors have achieved the above object.
After intensive studies to achieve
Selected from at least one selected and a specific seaweed extract
By using at least one of
The skin's anti-aging effect
And found that the present invention was completed.
It is. That is, the skin external preparation of the present invention comprises (A)
Oxidized CoA represented by the general formula (I) and / or a salt thereof
At least one member selected from the group consisting of: (B) Funori (Gloiopeltidaceae)
(Monostromataceae), Millidae (Codiaceae), Ushike
Nori family (Bangiaceae), Giant family (Gigartinacea)
e), Bivalvia family (Bonnemaisoniaceae), Ibaranori family
(Hypneaceae), Pinaceae (Chordariaceae),
Arugaceae (Nemacystaceae), Durvilleaceae (Durvilleace)
ae), Lessoniaceae and Darsaceae (Rh
odymeniaceae)
It is characterized by containing at least one kind. According to the external preparation for skin of the present invention, skin cells
Has activation, promotion of metabolism, wound healing effect, etc.
Oxidized CoA and / or its salt excellent in anti-aging effect
At least one [component (A)] selected from the group consisting of
Biological hyaluronic acid synthesis promoter contained in excrement
Activates the ability of the vesicles to synthesize hyaluronic acid,
Improves moisturizing, flexibility and elasticity of the skin and prevents skin aging
At least one selected from the above specific seaweed extract
By using the species [(B) component] together,
Without inhibiting the anti-aging effect of skin
Aging of skin even better than anti-aging effect of skin having
An external preparation for skin having a preventive effect will be newly obtained.
(This point will be described in more detail in Examples, etc.)
). DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the contents of the present invention will be described in detail.
I will tell. The external preparation for skin of the present invention is represented by the above general formula (I).
Oxidized CoA and / or a salt thereof selected from
At least one species, Funori (Gloiopeltidaceae),
Rubiaceae (Monostromataceae), Milliaceae (Codiaceae),
Bossaceae (Bangiaceae), Gibbinaceae (Gigartinac)
eae), Bonnemaisoniaceae, Ibaranori
Family (Hypneaceae), Pinaceae (Chordariaceae),
Mozuku family (Nemacystaceae), Durville family (Durvillea)
ceae), Lessoniaceae and Darsaceae
(Rhodymeniaceae)
At least one of them is an active ingredient. The oxidized CoA of the component (A) used in the present invention
Is represented by the above general formula (I).
For example, sodium salt,
Um salt, potassium salt, calcium salt, magnesium salt,
Metal salts such as zinc salts are exemplified. Specifically, oxidized C
oA disodium salt, tetrasodium salt, hexasodium
Salt, hexapotassium salt, tetralithium salt, dicalcium salt,
Magnesium salts, dizinc salts and the like can be mentioned. These acids
CoA or a salt thereof may be used alone or in combination of two or more.
Can be used in combination. Above component (A) outside the skin
When used in skin preparations, the compounding amount is
0.001 to 5% (wt%, hereinafter simply referred to)
%), More preferably 0.01 to
2% and less than 0.001% for the purpose of the present invention
Some satisfactory skin aging prevention effects may not be demonstrated
In addition, even if it exceeds 5%, usually more effects will be exhibited.
Not. [0011] The seaweed belonging to the family Funori which is used in the present invention
For example, the genus Gloiopeltis is preferred.
No. As seaweeds belonging to the family Parasitaceae used in the present invention
Means, for example, the genus Monostroma,
Genus (Kornmannia), preferably human egg
It is a genus. As a seaweed belonging to the family of Mills used in the present invention
Is preferably, for example, genus Mill (Codium). In the present invention
Examples of seaweeds belonging to the family Botanaceae include,
Genus (Porphyra), genus (Bangia)
And preferably of the genus Amanori. [0012] The seaweed belonging to the family Virginaceae used in the present invention
For example, the genus Gingartina,
Rhodoglossum, Chondru
s) and the like are preferred. Belongs to the family of the stalks used in the present invention
As seaweed, for example, genus Asparagopsis
s) and the genus Bonnemaisonia, and the like.
Or the genus Kagikenori. Ibaranori used in the present invention
As the seaweed belonging to the family, for example, the genus Ibaranori (Hypn
ea) and the like are preferred. [0013] Seaweed belonging to the family Pineaceae used in the present invention
For example, genus Matsumo (Analipus), Okinawa
Genus Cladosiphon; preferably pine
It belongs to the genus Momo and the genus Okinawamozuku. Mozuku used in the present invention
As seaweeds belonging to the family, for example, Mozuku (Nemacyst
is) and the like. Belongs to the family Darvillia used in the present invention
As seaweed, for example, the genus Durvillea
Are preferred. Seaweed belonging to the Lessoniaceae family used in the present invention
As, for example, Lessonia, macro
The genus Macrocystis and the like are preferred. In the present invention
Examples of the seaweed belonging to the family Darus, for example, Darus
The genus (Rhodymenia) is preferred. In extracting the component (B) of the present invention,
The algae may be in an undried state, but may be air-dried or freeze-dried.
Drying by the method and then subjecting it to extraction is preferred in terms of extraction efficiency.
Good. Further, the method of extracting the component (B) of the present invention comprises:
There is no particular limitation, and the usual extraction method is adopted, and water and sodium chloride are used.
Thorium solution, hydrophilic organic solvent, hydrous hydrophilic organic solvent,
It is extracted from seaweed using other organic solvents and the like. As the hydrophilic organic solvent used in the above extraction,
Is, for example, methanol, ethanol, isopropanol
Alcohol, propylene glycol, 1,3
-Glycols such as butylene glycol, glycerin,
Setone, methyl ethyl ketone, acetonitrile, dimethyl
Lusulfoxide, dimethylformamide, etc.
These liquid mixtures and the like can be mentioned. In particular, water or water and methanol
Alcohol, lower alcohol such as ethanol, isopropanol
It is preferred to extract using a mixture of In this case
The ratio of water to lower alcohol is 0 for lower alcohol / water.
/ 100 to 70/30 (v / v: volume ratio)
Preferably, it is more preferably 0/100 to 40/60.
You. The ratio between the dried seaweed and the extraction solvent is
The dry matter / solvent ratio is preferably in the range of 1/50 to 1/2. Ma
The extraction temperature is not particularly limited as the extraction conditions.
At a temperature of 5 to 80 ° C, preferably 5 to 50 ° C,
It is preferable to carry out the stirring for up to 24 hours.
Outgoing pH, especially if not inclined to extreme acidity and alkalinity
No restrictions. The extraction residue generated by the above extraction operation is further separated by sea
By repeating the extraction operation together with the dried algae, etc.
It is also possible to increase the extraction efficiency. In addition, this extraction
The effluent can be used as it is, or used as a diluent,
It may also be used as a condensed extract,
It may be finished or prepared in paste form. When prepared as a dry powder, water or water
Contains low levels of methanol, ethanol, isopropanol, etc.
It can also be used by dissolving it in a graded alcohol in advance.
It is preferable to use it after solubilizing it in a skin external preparation composition containing water.
Good. The seaweed extract may be used alone or in combination of two or more.
Can be mixed and used, and compounded at any concentration
It can be used, but its amount is based on the total amount of
Is preferably 0.01 to 50%, more preferably 0.05 to 2%.
0% is preferable, and particularly preferably 0.1 to 10%,
If it is less than 0.01%, satisfactory anti-aging effect of the skin will occur
May not be volatilized, and even if it exceeds 50%,
No further effect is exhibited. Composition ratio of component (A) and component (B) of the present invention
In this case, 1/5000 to 5000/1 is preferable, and
1 / 250-250 / 1 is preferred, and especially 1 / 100-
100/1 is preferred. Outside the above range, component (A)
When it is difficult to obtain the effect of the combined use of component (B) and
There is. The dosage of the external preparation for skin of the present invention depends on the amount of the external preparation.
Various selection depending on the dosage form, usage method, usage method, etc. of the composition
(A)
The amount of the component and the component (B) and the proportion of the
And the amount of each dosage form to be described later.
The anti-aging effect of the present invention by applying
Fruit can be obtained. The external preparation for skin of the present invention comprises
, Oil, water, surfactant, moisturizing, lower alcohol,
Thickeners, antioxidants, chelating agents, pH adjusters, preservatives
Agents, fragrances, dyes, UV absorbers, UV scattering agents, Vitamins
For general cosmetics, soap baths, etc.
Raw materials to be used can be blended. Specifically, oil
Olive oil, jojoba oil, castor oil, cacao
Fat, camellia oil, coconut oil, wood wax, grape seed oil, avoca
Oils such as de-oil, mink oil, egg yolk oil, hardened oil, whale wax,
Beeswax, lanolin, carnauba wax, candelilla wax
Waxes, liquid paraffin, ceresin, squalane, etc.
Microcrystalline wax, paraffin wax,
Hydrocarbons such as petrolatum, stearic acid, oleic acid,
Lauric acid, myristic acid, isostearic acid, oleic
Acid, fatty acids such as behenic acid, cetanol, stearyl
Alcohol, lanolyl alcohol, octyldodecano
, Alcohols such as hexyldecanol, myristic
Isopropylate, butyl stearate, palmitic acid
Isopropyl, octyldodecyl myristate, choles
Esters such as terol oleate are exemplified. As the surfactant, stearic acid is used.
Sodium, sodium cetyl sulfate, polyoxyethylene
Lauryl ether phosphate, sodium lauryl phosphate
System, triethanolamine palmitate, N-acylg
Anionic surfactants such as sodium rutamate,
Tearyldimethylbenzylammonium, stearyl chloride
Cationic surfactants such as rutrimethylammonium, salts
Alkylaminoethylene glycine solution, lecithin, etc.
Surfactant, glyceryl monostearate, monostearate
Sorbitan arate, sucrose fatty acid ester, monostea
Propylene glycol arate, polyoxyethylene
Rail ether, polyethylene glycol monostearate
, Polyoxyethylene sorbita monopalmitate
Polyoxyethylene coconut fatty acid monoethanolamine
, Polyoxyethylene polyoxypropylene glycol
, Polyoxyethylene castor oil, polyoxyethylene
Non-ionic surfactants such as lanolin can be exemplified.
Wear. As humectants, glycerin, 1,3-butane
Tylene glycol, propylene glycol, sorbitol
, Polyethylene glycol, dipropylene glycol
Polyhydric alcohols such as amino acids, sodium lactate, pyro
NMF components such as sodium lidone carboxylate, hyaluro
Acid, collagen, mucopolysaccharide, chondroitin sulfate, etc.
And the like. The lower alcohols include ethanol, i.
Sopropanol and the like can be exemplified. As a thickener
Sodium alginate, xanthan gum, silica silicate
Luminium, quince seed extract, tragacanth gum,
Natural polymer substances such as starch, methylcellulose, hydrid
Roxyethyl cellulose, carboxymethyl cellulose
, Soluble starch, semi-synthesis of cationized cellulose, etc.
High polymer substance, carboxyvinyl polymer, polyvinyl alcohol
Examples of synthetic high molecular substances such as alcohol
You. As an antioxidant, dibutylhydroxytoluene
Butylhydroxyanisole, propyl gallate,
Ascorbic acid and the like can be exemplified. As a chelating agent, edetate dinatrium is used.
Ethanehydroxydiphosphate, pyrophosphate,
Hexametaphosphate, citric acid, tartaric acid, glucuronic acid
And the like. Hydroxyl as a pH adjuster
Sodium chloride, triethanolamine, citric acid, que
Sodium phosphate, boric acid, borax, sodium hydrogen phosphate
And the like. As a preservative, para
Methyl oxybenzoate, dehydroacetic acid, salicylic acid, ammonium
Examples include benzoic acid, sorbic acid, and benzalkonium chloride
Can be As the ultraviolet absorber, 2-hydroxy-
4-methoxybenzophenone, octyldimethylparaa
Minobenzoate, ethylhexyl paramethoxy cyna
Mate, etc., as titanium dioxide,
Examples include phosphorus and talc. Vitamins and
As for vitamin A, vitamin B, vitamin C, vitamin
D, Vitamin E, Vitamin F, Vitamin K, Vitamin
P, vitamin U, carnitine, ferulic acid, γ-oryza
Nol, α-lipoic acid, orotic acid and derivatives thereof, and
Pantothenic acid and its derivatives (pantothenylethyl
-Tel). As amino acids
Is glycine, alanine, valine, leucine, isoleu
Syn, serine, threonine, phenylalanine, fir
, Tryptophan, cystine, cysteine, methionine
, Proline, hydroxyproline, asparagine
Acid, glutamic acid, arginine, histidine, lysine and
And derivatives thereof. The composition for external use on the skin of the present invention is incorporated in the composition.
Optional components are not limited to these,
For example, extracts of animal, microbial and plant origin may be added as appropriate.
Can be The external composition for skin of the present invention includes
Lotion, cream, pack, skin milk
(Emulsion) and various other product forms.
It is not specified. These products are the skin of the present invention
Manufactured by appropriately mixing the external preparation and the above optional components
can do. Specific examples of the use as skin cosmetics are described below.
These are shown in (1) to (5) below. (1) As a lotion and an anti-aging agent for serums, component (A) 0.1-5% and
(B) Contains 0.1 to 10% of a component, and is an optional component.
Alcohol 0-20%, surfactant 0-2%, moisturizing
Agent 2-15%, pH adjuster 0-3%, purified water balance,
Lotion containing trace amounts of preservatives, 0 to trace amounts of pigment, and trace amounts of fragrance
And serums. (2) Cream for skin As an antiaging agent for skin, component (A) 0.1 to 5% and
(B) Contains 0.1 to 10% of a component, and is an optional component.
Oil content 10-70%, surfactant 2-7%, humectant 1
10%, pH adjuster 0-3%, Purified water balance, Preservative
A skin cream containing trace amounts and trace amounts of perfume. (3) 0.1-5% of component (A) as an antiaging agent for emulsion skin
(B) Contains 0.1 to 10% of a component, and is an optional component.
Oil content 10-40%, alcohols 0-15%, surfactant
1-5% humectant, 1-10% humectant, 0-2% thickener, p
H preparation 0-3%, Purified water balance, Preservative trace, Fragrance
Emulsion containing trace amounts. (4) Packing agent As an antiaging agent for skin, component (A) 0.1 to 5% and
(B) Contains 0.1 to 10% of a component, and is an optional component.
Alcohol 2-10%, humectant 2-10%, inorganic powder
Body 0-20%, thickener 10-20%, purified water balance,
A pack containing a small amount of preservatives and a small amount of fragrance. (5) Gel agent 0.1-5% of component (A) as an antiaging agent for skin and
(B) Contains 0.1 to 10% of a component, and is an optional component.
Alcohol 0-10%, humectant 2-20%, thickener
1-20%, pH adjuster 0-30%, purified water balance,
Gel containing trace amounts of preservatives, 0 to trace amounts of pigment, and trace amounts of fragrance
Agent. Further, the external preparation for skin of the present invention is used as a bath agent.
When used, in addition to the above components, sodium chloride,
Potassium iodide, ammonium chloride, sodium sulfate,
Sodium bicarbonate, sodium carbonate, sodium sesquicarbonate
Lium, aluminum sulfate, potassium sulfide, potassium sulfate
Acid, boric acid, borax, silicic anhydride, metasilicic acid, sulfurous acid
Sodium, phosphoric acid, sodium hydrogen phosphate, diphosphate
Potassium hydrogen, sodium silicate, sodium polyphosphate
Inorganic substances such as calcium phosphate, sodium hydrogen phosphate
Salts and inorganic acids may be added.
If necessary, crude drugs, binders, essential oils, proteases,
Other components can also be added. To meet these needs
Specific examples of the components to be added first are shown below. As crude drugs, for example, Soujutsu,
Kujutsu, valerian, kayai, kouboku, senkyu
Cormorant, spruce, touki, ginger, ogon, sanshi
Si, gypsy, aloe, carrot, calyx, peonies
Ku, mint leaves, bukuro, shobu, matsubusa, beer
Comb, saffron, oak, fennel, cock, cancer
Pi, chamomile, radish, willow, camphor, elder
Ko, Sokuzu, Nakinata Koju, Japanese Maple, Sekisho,
Artemisia, Hypericum, Yuzu, Daidai, Momo, Saika
Ji, loquat, honeysuckle, yogura, bodaiju, conker
Tree, yarrow, hop, rosemary, cabano,
Pine, yarenzura, lantana, licorice, foxglove
, Marronnier and the like. These are the powders
However, the extract may be used. As the binder, for example, casein, cal
Boxymethylcellulose sodium, water-soluble gelatin,
Pectin, starch, methylcellulose, ethylcellulo
Glucose, sodium alginate, polyvinyl alcohol,
Polyvinyl pyrrolidone, polyvinyl methyl ether,
Polyethylene glycol, karaya gum, locust bean
Gum, tragacanth gum, carrageenan, carbopol,
Acacia gum, agar and the like. As essential oils
Is, for example, peppermint oil, jasmine oil, camphor oil,
Cypress oil, spruce oil, ryu oil, turpentine oil, cauliflower
Oil, bergamot oil, tangerine oil, shobu oil, pine
Oil, lavender oil, bay oil, clove oil, hiba oil, rose
Oil, eucalyptus oil, lemon oil, thyme oil, peppermint
Oil, rose oil, sage oil, menthol, cineole, o
Higenol, Citral, Citronellal, Borneaux
Le, linalool, geraniol, camphor, zimo
Le, spilanthol, pinene, limonene, turpentine
And the like. As a protease, for example,
Pepsin, trypsin, chymotrypsin, cathepsin,
Papain, promelain, fusin and bacterial yeast, mold
Derived protease. The external preparation for skin of the present invention is used as a bath preparation
Specific examples of the case are shown in the following (1) to (3). (1) Bath agent In addition to the above components, component (A) as an antiaging agent for skin
Containing 0.1 to 5% and 0.1 to 10% of the component (B),
Contains inorganic salt and inorganic acid balance, trace amount of fragrance and pigment
Bath agent. (2) Body shampoo In addition to the above components, (A) component as an antiaging agent for skin
Containing 0.1 to 5% and 0.1 to 10% of the component (B),
Surfactant 5-40%, humectant 1-20%, thickener 0.
5-5%, chelating agent 0.05-0.5%, purified water rose
Body shampoo that contains traces, perfume and trace amounts of pigment. (3) Body rinse In addition to the above components, component (A) as an antiaging agent for skin
Containing 0.1 to 5% and 0.1 to 10% of the component (B),
Oil 5-30%, surfactant 0.5-5%, humectant 0
Contains 10%, purified water balance, trace amount of preservative, trace amount of fragrance
Body rinse. EXAMPLES The present invention will be described below with reference to examples and the like.
However, the present invention is not limited to these examples.
No. Note that “%” in each example is “% by weight”.
is there. Production Example (Production of Seaweed Extract) D belonging to the genus Durvilleaceae (Durvilleaceae)
urvillea antarctica 100 g dry matter
It was immersed in water and extracted at room temperature for 3 hours with stirring.
Then, by concentration and freeze-drying, Durvillea a
20 g of ntarctica water extract was obtained. Example 1 Oxidized CoA was converted to hydrophilic ointment / white petrolatum to 1/1 (weight
Ratio) to the base blended at a ratio of 0.5%
Skin anti-aging agent (Sample 1), Du obtained in the above Preparation Example
rvillea antarctica water extract with hydrophilic ointment / white petrolatum
So that it becomes 1.0% in the base compounded with 1/1
Antioxidant for skin (sample 2) and hydrophilic ointment /
Oxidized C in a base containing white petrolatum at a ratio of 1/1
oA 0.5% and Durvillea antarctica water extract 1.0
%, Respectively, and prepare a skin anti-aging agent (sample 3).
And subjected to the following tests. Test Example 1 10 adult males and females (male 5
Name, 5 women) on the lower leg with rough skin
Four test sites were set. Then, the above samples 1 to 3
(Test sample) and hydrophilic ointment / white petrolatum were divided by 1/1
Combined base (control sample) twice a day (morning / night)
For the next two weeks, apply to the test site and visually observe the degree of improvement in skin roughness
By the following evaluation criteria
The amount was measured (room temperature 20 ° C, humidity 50%,
S company SKICON200). Stratum corneum water content at start
The difference in the water content of the stratum corneum after a week (the increase in the water content of the stratum corneum) was shown.
The higher the value of the horny layer water increase, the better. So
And comprehensive evaluation based on the degree of improvement in skin roughness and changes in the water content of the stratum corneum
Value. The results are shown in Table 1 below. [Evaluation criteria for skin roughness improvement degree]-: No change ±: Slight improvement +: Improvement ++: Notable
[Table 1] (Consideration of Table 1) Sample 1 is an oxidized CoA alone antiaging agent for skin, sample 2
Is the Durvillea antarctica water extract obtained in the preparation example alone
An antioxidant for skin, Sample 3 is an oxidized Co of the present invention.
Peeled skin in combination with A and Durvillea antarctica water extract
Sample 3, which is an antiaging agent for the skin and is the present invention, is an oxidized type
CoA alone sample 1 and Durvillea antarctica water extraction
The degree of improvement in skin roughness and moisture, which is much better than Sample 2
It was found to show an increase. Example 2 (Preparation of cosmetic cream) and ratio
Comparative Examples 1-3 Formulations A and B shown in Table 2 below were mixed and dissolved at 70 ° C, respectively.
After that, add A to B and emulsify uniformly to make a cosmetic cream
Prepared. [Table 2] Test Example 2 Including Oxidized CoA and Durvillea antarctica water extract
The effectiveness of the cosmetic cream of Example 2 above was tested in the following test.
More evaluated. Wrinkles around the eyes (outside and below the eyes)
30 women (30-50 years old) were compared with the product of the present invention and Comparative Example 1,
Using the product of the present invention and Comparative Example 2 and the product of the present invention and Comparative Example 3
Divided into three counties, twice a day (morning and night), separately on the left and right face
The half face method was used. And large
About wrinkles, fine wrinkles, skin texture (texture, gloss, moisture), feeling of use
And conduct a questionnaire survey on the feeling of use.
Table 3 below summarizes the results. [Table 3] (Consideration of Table 3) The product of the present invention (Example 2) was prepared from oxidized CoA and Durvillea.
Comparative Example 1 without water extract of antarctica, oxidized form C
Comparative Example 2 containing only oA, Durvillea antarctica
Compared with Comparative Example 3 containing only the water extract,
Wow, skin quality (texture, gloss, moisture) and feeling of use are significantly improved
Turned out to be. The following are examples of other skin external preparations of the present invention.
An example is shown. Example 3 (Preparation of serum) A serum having the following composition was prepared by a conventional method. Oxidized CoA 0.1% Durvillea antarctica water extract 0.2 Glycerin 4.0 Ethanol 10.0 Xanthan gum 0.3 Fragrance trace amount Purified water Balance 100.0% Example 4 [Preparation of bath agent (granular)] Granules)
Was. Potassium hydrogen carbonate Balance Sodium sulfate 30.0 Oxidized CoA.2Na 1.0 Gloiopeltis Furcata Water extract 2.0 Magnesium oxide 2.0 Sodium carboxymethyl cellulose 1.0 Chamomile 0.5 Vitamin E 0.5 Perfume 1.0 Dye 0.1 100.0% Example 5 (Preparation of body shampoo) Prepare a body shampoo with the following composition by the method
Was. Potassium coconut fatty acid 5.0% Potassium oleate 20.0 Coconut fatty acid diethanolamide 3.0 Glycerin 10.0 Sodium sulfate 2.0 EDTA 0.1 Oxidized CoA · 6Na 2.0 Cladoshiphon okamuranus water extract 1.0 Perfume proper amount Pigment proper amount Preservative proper amount Purified water Balance 100.0% According to the present invention, the skin including wrinkles
Prevents skin aging, and is smooth and moist
It has a remarkably superior effect that can give fresh skin
An external skin preparation is provided. Therefore, the excellent skin of the present invention
An external preparation for skin having an anti-aging effect of
Reams, emulsions, lotions, serums, packs, gels,
Powder, lip balm, lipstick, under makeup
, Foundation, sun care, bath preparation, body sha
Pump, body rinse, soap, cleansing pho
, Ointment, jelly, aerosol, etc.
Can be used widely.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI A61K 31/7076 A61K 31/7076 35/80 35/80 Z A61P 17/16 A61P 17/16 (56) References JP2 JP-49729 (JP, A) JP-A-7-101871 (JP, A) JP-A-6-9422 (JP, A) JP-A-2-237906 (JP, A) JP-A-7-10769 (JP, A) JP-A-2-124810 (JP, A) JP-A-3-38510 (JP, A) JP-A-1-207220 (JP, A) JP-A-50-31051 (JP, A) JP-A-60-1985 13709 (JP, A) JP-A 8-259443 (JP, A) JP-A 1-186813 (JP, A) JP-A 6-179625 (JP, A) JP-A 64-16713 (JP, A) JP-A-56-135412 (JP, A) JP-A-9-40523 (JP, A) JP-A-9-176036 (JP, A) -67266 (JP, A) JP-A-8-198741 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 A61K 35/80 JICST file (JOIS )

Claims (1)

(57) [Claim 1] (A) At least one selected from oxidized compounds represented by the following general formula (I) and / or salts thereof, and (B) Funoriaceae (Gloiopeltidaceae), Human Exercaceae (Monostromataceae), Millaceae (Codiaceae), Bossaceae (Bangiaceae), Girdaceae (Gigartinacea)
e), Bivalvia family (Bonnemaisoniaceae), Ibaranori family (Hypneaceae), Pinus family (Chordariaceae), Mozuku family (Nemacystaceae), Durvilleaceae (Durvilleace family)
ae), Lessoniaceae and Darsaceae (Rh
external preparation for skin comprising at least one selected from seaweed extracts belonging to odymeniaceae).