JP2000178118A - Humectant, skin cosmetic and bathing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a humectant, a skin cosmetic and a bathing agent having excellent moisture absorption ability and moisture retaining ability free from a feeling of stickiness. SOLUTION: This humectant characteristically contains N-monomethylglycine. This skin cosmetic and a bathing agent contain the humectant. N-Methylglycine used in this invention is a well-known substance, named sarcosine as another name and is readily obtainable. The amount of the humectant related to this invention is preferably 0.001-30.0 wt.%, more preferably 0.01-10.0 wt.% based on the total of the skin cosmetic. When the amount of the humectant is <0.001 wt.%, occasionally an effect is not sufficiently exhibited. On the other hand, when the amount exceeds >=30.0 wt.%, occasionally an effect corresponding to the mixed amount is not obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a humectant, and more particularly, to a humectant, a skin cosmetic and a bath additive which are safe and have a high moisturizing effect.

[0002]

2. Description of the Related Art The skin has a function of protecting the living body from various environmental changes and stimuli from the outside world. In particular, the stratum corneum located at the outermost layer of the epidermis acts as a buffer between the outside world and the living body. Is responsible for.

[0003] The stratum corneum needs a moderate amount of water in order to flexibly respond to various activities of the living body and to maintain elasticity, flexibility, protection function and the like. As one of the mechanisms by which the stratum corneum retains moisture, NMF (Natural moi
The presence of NMF is considered to be a natural moisturizing factor. The main components of this NMF are sodium pyrrolidonecarboxylate and amino acids. In addition, when moisture in the stratum corneum is lost due to changes in the external environment, the elasticity, flexibility,
It is known that a protection function or the like is impaired and causes various troubles. Therefore, a hydrophilic humectant such as hyaluronic acid or collagen is blended in cosmetics for the purpose of maintaining appropriate water content of the stratum corneum and repairing or preventing skin troubles, and pyrrolidone which is an NMF component is used. Sodium carboxylate and amino acids are also widely used as humectants.

However, when a large amount of sodium pyrrolidonecarboxylate is used, a change in the volume of the emulsified particles and a change in the structure of the polymer stabilizer to be added are caused at the same time, and the emulsification stability of the emulsified composition is still insufficient. This is particularly noticeable in oil-in-water emulsion type skin cosmetics. In addition, since amino acids are small molecules that can penetrate into the skin, they are absorbed into the stratum corneum,
Although it may function similarly to MF, it has the drawback that the amino acid itself does not have excellent moisture absorption / moisturizing ability.

[0005]

Under such circumstances, the present inventors have conducted intensive studies to solve the above-mentioned problems and found that N
N-monomethylglycine, which is an N-monomethylated derivative of glycine, which is contained in proteins abundantly in amino acids that are MF components, has a moisture absorption / humidification ability equivalent to that of sodium pyrrolidonecarboxylate. The present inventors have found that the composition is very excellent in stability even when blended in a bathing agent, and completed the present invention.

[0006] That is, an object of the present invention is to provide a humectant, a skin cosmetic, and a bathing agent which have excellent hygroscopicity and moisturizing ability and have no sticky feeling.

[0007]

The above object is achieved by a humectant characterized by comprising N-monomethylglycine, and a skin cosmetic and a bath preparation characterized by containing the humectant. That is, the present invention relates to a humectant characterized by using N-monomethylglycine as an active ingredient, and a skin cosmetic and a bath preparation characterized by containing the humectant.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.

The humectant of the present invention can be incorporated into, for example, skin cosmetics, bath additives, pharmaceuticals, quasi-drugs, foods, and the like. In addition, among the skin cosmetics, an excellent effect in terms of stability is further exerted by blending it into an oil-in-water emulsion-type skin cosmetic.

[0010] N-methylglycine used in the present invention is a known substance, and is also known as sarcosine, and can be easily obtained.

The humectant according to the present invention is preferably 0.001 to 30.0% by weight (hereinafter abbreviated as wt%), more preferably 0.01 to 0.01% by weight based on the total weight of the skin cosmetic.
10.0 wt% is used in combination. 0.001wt%
If it is less than 3, the effect may not be sufficiently exhibited.
If the content is 0.0 wt% or more, the effect corresponding to the blending amount may not be obtained.

The skin cosmetics according to the present invention can be made into various dosage forms such as lotions, emulsions, creams, ointments, packs, makeup bases, make-up materials, massage materials, etc. in accordance with the usual methods. It is possible.

The humectant of the present invention is preferably used in an amount of 0.01 to 10.0% by weight, more preferably 0.1 to 5.0% by weight, based on the total weight of the bath agent. 0.01
If the amount is less than wt%, the effect of the present invention may not be sufficiently exhibited. On the other hand, even if the amount exceeds 10.0 wt%, the effect corresponding to the amount may not be obtained.

The bath preparation of the present invention comprises a powder,
Various dosage forms such as granules, tablets, and liquid preparations can be made.

The skin cosmetics and bath preparations of the present invention include a surfactant, a bactericide, a preservative, a keratolytic agent, an antioxidant, a fragrance, a pigment and the like within a range in which the object of the present invention is achieved. They can be appropriately blended.

The base of the skin cosmetic may be a known base, for example, silicone oils such as methylphenylpolysiloxane and dimethylpolysiloxane, hydrocarbons such as paraffin and petrolatum, olive squalane, rice squalane, rice bran Vegetable oils such as oil, olive oil, soybean oil, rice germ oil, jojoba oil, castor oil, safflower oil, sunflower oil, olive oil, macadamia nut oil, beeswax, mokuro,
Waxes such as carnauba wax, ester oils such as octyldodecyl myristate and cetyl palmitate, higher alcohols such as cetanol, behenyl alcohol, stearyl alcohol, and isostearyl alcohol; sterols such as cholesterol and phytosterol; branched fatty acid cholesterol esters; macadamia nuts Sterol fatty acid esters such as oil fatty acid phytosterol esters, stearic acid, myristic acid, isostearic acid, oleic acid, salts of higher fatty acids such as iso-type long-chain fatty acids and anteiso-type long-chain fatty acids, sodium cetyl sulfate,
N-stearoyl-L-glutamate, anionic surfactant such as glycyrrhizinate, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester,
Nonionic surfactants such as polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester, modified silicon, sucrose ester, etc., and cationic surfactant such as tetraalkylammonium salt Agents, betaine type, sulfobetaine type, sulfoamino acid type etc. amphoteric surfactants, natural surfactants such as lecithin, lysophosphatidylcholine, ceramide, cerebroside, etc., processing oils such as hardened oils, triisosoteearin Acid glycerides, triglycerides such as capryli-capric acid glyceride, glyceryl 2-ethylhexanoate, tar pigments, coloring pigments such as iron oxide, parabens, preservatives such as phenoxyethanol,
Pigments such as titanium oxide and zinc oxide, antioxidants such as dibutylhydroxytoluene, primary alcohols such as ethanol,
Sodium chloride, magnesium chloride, sodium sulfate,
Inorganic salts such as potassium nitrate and sodium silicate; organic acid salts such as sodium succinate and sodium aspartate;
Salts such as ethanolamine hydrochloride, ammonium nitrate, arginine hydrochloride, phosphate, citrate, acetate, carbonate, trishydroxymethylaminomethane hydrochloride, diisopropylamine dichloroacetate, dipropylene glycol, 1,3-butylene glycol, and glycerin , Propylene glycol, sorbitol, malbitol, polyhydric alcohols such as diglycerin, carboxyvinyl polymer,
Thickeners such as xanthan gum, carrageenan, alkyl-modified carboxyvinyl polymers, chelating agents such as edetic acid, neutralizing agents such as potassium hydroxide, diisopropanolamine, and triethanolamine; biopolymers such as hyaluronic acid and collagen; lactic acid bacteria , Yeast, etc., plants such as chamomile, assembly, aloe, peach, carrot, horsetail, mulberry, peach leaves, sage, loquat leaves, cucumber, vegetation, hibiscus, turmeric, rosemary, orgon, licorice etc. Extract, serine, threonine, N-
Amino acids such as methyl-1-serine, aminobutyric acid, and hydroxyaminobutyric acid; silicon beads such as polymethylsilsesquioxane; ultraviolet absorbers such as hydroxymethoxybenzophenone sulfonate; vitamins A and B;
Vitamins such as Cs and Es, fragrances and the like can be used, but are not limited thereto.

[0017]

The following examples are provided to clarify the effects of the humectant according to the present invention, but the present invention is not limited to these examples. The numbers in the prescription are all wt%.

Test Example 1: Evaluation of feeling of use of N-monomethylglycine The feeling of use of a cream containing N-monomethylglycine and a cream containing sodium pyrrolidonecarboxylate were compared. According to the following formulation, component (A) was uniformly mixed and dissolved at 80 ° C., and then component (B) was mixed and dissolved therein (mixture I). Separately, the component (D) was uniformly mixed and dissolved at 80 ° C., and then the component (C) was mixed and dissolved therein (mixture liquid II). Next, the mixture II was gradually added to the mixture I, and the mixture was cooled to 30 ° C. with sufficient stirring to prepare a cosmetic cream. By using the blind method,
Comparison and evaluation were performed by 0 female panelists. Moisturizing items (do not dry, have moisture)
The evaluation was based on the number of people who answered that the following criteria were met.

(A) Example 1 Comparative Example 1 Cetanol 33 Glycerin monostearate 2.5 2.5 Polyoxyethylene (20EO) cetyl ether 1.5 1.5 Liquid paraffin 10 10 Tri-2- Glycerin ethylhexanoate 55 Methylpolysiloxane 11 1 (B) Butyl paraoxybenzoate 0.1 0.1 (C) Methyl paraoxybenzoate 0.15 0.15 Disodium edetate 0.1 0.1 N-monomethyl Glycine 1-sodium pyrrolidonecarboxylate-1 (D) Sodium N-stearoyl-L-glutamate 0.9 0.9 Dipropylene glycol 55 Purified water Remaining amount Remaining amount------------- −−−−−−−−−−−−−−−−−−−−−−−−−− Evaluation result Strongly felt 7 6 Somewhat felt 2 2 Young Feel 1 2 I do not feel too much feeling not 0 0 totally 0 0

From the above results, it was found that the cream containing N-monomethylglycine (Example 1) gave a moist feeling equal to or higher than that of the cream containing sodium pyrrolidonecarboxylate (Comparative Example 1).

Test Example 2: Storage stability test An emulsion having the following formulation was prepared by a conventional method. The appearance of the emulsified state after leaving them at room temperature for one day was observed.
, The case where no abnormality was observed was represented by ○.

Example 2 Comparative Example 2 N-Monomethylglycine 1.0-Sodium pyrrolidonecarboxylate-1.0 Liquid paraffin 10.0 10.0 Polyoxyethylene hydrogenated castor oil (60EO) 0.5 0. 5 Carboxyvinyl polymer 0.2 0.2 Diisopropanolamine 0.2 0.2 95% ethanol 0.5 0.5 Methyl parahydroxybenzoate 0.1 0.1 Purified water Remaining residual amount ------ −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Storage stability ○ × −−−−−−−−−−−−−−−−− −−−−−−−−−−−−−−−−−−−−−−−−−−

From the above results, it was found that the emulsion containing N-monomethylglycine had better storage stability than the emulsion containing sodium pyrrolidonecarboxylate.

Test Example 3 Measurement of Moisture Absorption and Moisturizing Ability N-monomethylglycine and other compounds (glycine and sodium pyrrolidonecarboxylate) were compared for their moisture absorbing and moisturizing ability. The weight change when each sample was placed in a low-humidity environment and a high-humidity environment was measured, and the moisture absorption and moisture retention were calculated. Each sample was allowed to stand for 5 days in a low humidity environment of 23 ° C. and 14% RH (relative humidity), and the dry weight of the sample was measured (= Wa).
0). Thereafter, the sample was allowed to stand for 7 days in a high humidity environment of 23 ° C. and 99% RH (relative humidity), and the sample weight was measured (= Wa).
7). Further, the sample was transferred to a low humidity environment of 23 ° C. and 14% RH (relative humidity), dried, and weighed after 1, 3, 5, 7, and 9 days (= Wb 1, 3, 5, 7, 9). ). The moisture absorption of each sample was calculated by the following equation, and the obtained results are shown. The numerical values are average values (n = 4). Moisture absorption (%) = (Wa7−Wa0) × 100 / Wa
0

The moisture absorption (Wa7-Wa0) is set to 100
The moisturizing rate (percentage of residual moisture over time) at the time of was calculated by the following formula, and the obtained results are shown in Table 1 below together with the moisture absorption rate. The numerical values are average values (n = 4). Moisturizing rate (%) = (WbN−Wa0) × 100 / (Wa7
−Wa0) where N = 1, 3, 5, 7, 9

[0026]

[Table 1]

As is apparent from Table 1, N according to the present invention is
-It was confirmed that the moisture absorption of monomethylglycine was about the same as that of sodium pyrrolidonecarboxylate, and was significantly higher than that of glycine. In addition, glycine lost most of the moisture absorbed in a high-humidity environment within one day after being transferred to a low-humidity environment and dried. Although sodium pyrrolidonecarboxylate and N-monomethylglycine continued to lose water gradually after being transferred to a low-humidity environment, it was found that both had the same moisturizing ability.

From the above, it has been proved that N-monomethylglycine has a moisture absorbing / humidifying ability as excellent as sodium pyrrolidonecarboxylate.

Examples 3 and 4 (cream) According to the following formulation, component (A) was uniformly mixed and dissolved at 80 ° C., and then component (B) was mixed and dissolved therein (mixture I). Separately, the component (D) was uniformly mixed and dissolved at 80 ° C., and then the component (C) was mixed and dissolved therein (mixture liquid II). Next, the mixture II was gradually added to the mixture I, and the mixture was cooled to 30 ° C. with sufficient stirring to prepare a cosmetic cream.

(A) Example 3 Example 4 Cetanol 33 Glycerin monostearate 2.5 2.5 Polyoxyethylene (20EO) 1.5 1.5 Cetyl ether Liquid paraffin 10 10 Tri-2- Ethylhexanoic acid 55 Glycerin methylpolysiloxane 11 1 (B) Butyl paraoxybenzoate 0.1 0.1 (C) Methyl paraoxybenzoate 0.15 0.15 Disodium edetate 0.1 0.1 N-monomethyl Glycine 0.01 2 Sodium pyrrolidonecarboxylate-1 (D) N-stearoyl-L-glutamic acid 0.9 0.9 Sodium dipropylene glycol 55 Purified water Remaining remaining

Examples 5 to 7 (Lotion) Lotions were prepared by mixing and dissolving the following components in a conventional manner.

Example 5 Example 6 Example 7 Ethanol 5.55 Glycerin 5.55 Polyoxyethylene hardened 0.5 0.5 0.5 Castor oil (60EO) Methylparaben 0.02 0.02 02 Fragrance 0.05 0.05 0.05 0.05 N-monomethylglycine 0.1 1 2 Purified water Remaining Remaining Remaining

Example 8 (Bath agent) According to the following formulation, each component was mixed by a conventional method to prepare a bath agent. In addition, this bath agent is diluted about 3000 times at the time of use.

Sodium sulfate 85 Perfume and surfactant Appropriate amount Organic dye Appropriate amount N-monomethylglycine 10 Sodium bicarbonate Remaining amount

Examples 9 to 10 (Ointment) According to the following formulation, the components of (B) were mixed while heating to 80 ° C. in a hot water bath, and the mixture was heated to 80 ° C.
Was gradually added to the mixture of the components with stirring. Next, vigorously stirring with a homogenizer for 2.5 minutes (2500
rpm) to sufficiently emulsify and disperse each component, and then gradually cooled while stirring to obtain an ointment.

Example 9 Example 10 (A) Squalane 4.7 4.7 White Vaseline 24 24 Stearyl Alcohol 8.7 8.7 Isopropyl Myristate 66 6 Polyethylene Glycol Monostearate 1.3 1.3 Polyoxyethylene Alkyl ether phosphate 2.3 2.3 Glycerol monostearate 22 22 Butyl parahydroxybenzoate 0.1 0.1 (B) Methyl paraoxybenzoate 0.1 0.1 Butylene glycol 6.7 6.7 N −Monomethylglycine 0.01 0.1 Purified water Remaining Remaining

Examples 11 to 12 (gel) According to the following formulation, each component of (A) was swollen with a portion of water (D), and after dissolving component (C) with the remaining water (D),
Both were uniformly mixed (mixture I). Separately, the component (B) was uniformly mixed (mixture II). The mixed solution I was added to the mixed solution I and dispersed to obtain a gel.

Example 11 Example 12 (A) Carboxyvinyl polymer 0.5-alkyl-modified carboxyvinyl polymer-0.5 (B) Ethanol 10 10 Diisopropanolamine 0.5 0.5 Polyoxyethylene monolaurate 3 0.3 Sorbitan (20EO) Perfume Appropriate amount Appropriate amount (C) Glycerin 55 N-monomethylglycine 0.1 0.1 (D) Purified water Remaining amount

Examples 13 and 14 (Hair Tonic) According to the following formulation, in component (A), a perfume was dissolved with a perfume solubilizer, and then added to ethanol while stirring at room temperature to dissolve the component (B). It was added sequentially and dissolved (mixture I). Separately, the component (C) was dissolved and added to the mixed solution I with stirring to make the mixture uniform, followed by filtration to obtain a hair tonic.

Example 13 Example 14 (A) Ethanol 70 70 Perfume solubilizer Proper amount Proper amount Perfume / Dye Proper amount Appropriate amount (B) dl-α-tocopherol acetate 0.05 0.05 Alkyldiaminoethyl hydrochloride 0.2 0.0 2 Dipotassium glycyrrhizinate 0.1 0.1 Propylene glycol 33 1-Menthol 0.1 0.1 (C) Lactic acid 0.1 0.1 Chelating agent Suitable amount Suitable amount N-monomethylglycine 0.01 0.1 Purified water residue Amount Remaining

[0041]

As described above, according to the present invention, moisture absorption and
N-Monomethylglycine is useful as a moisturizer with excellent moisturizing properties, and N-monomethylglycine is blended as a moisturizing agent to provide excellent moisturizing properties, a more favorable feel, and excellent stability. Obviously, a bath as well as a bath can be provided.

 ──────────────────────────────────────────────────の Continuing on the front page (72) Inventor Moto Hayase 5-3-28 Kotobukicho, Odawara-shi, Kanagawa Kanebo Co., Ltd. Cosmetics Research Laboratory F-term (reference) 4C083 AB312 AB352 AC012 AC022 AC072 AC102 AC112 AC122 AC182 AC302 AC352 AC402 AC422 AC442 AC482 AC522 AC532 AC542 AC581 AC582 AC612 AC902 AD042 AD092 AD152 AD532 AD662 BB51 CC02 CC05 CC25 CC32 DD22 DD31 DD41 EE01 EE06 EE10 EE12 EE22 FF05

Claims (3)

[Claims] 1. A humectant comprising N-monomethylglycine. 2. A skin cosmetic comprising the humectant according to claim 1. 3. A bath preparation comprising the humectant according to claim 1.