JPS60188306A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, containing pyridoxine or a derivative thereof with L- ascorbic acid and an ester thereof together, capable of remarkably improving liver-spot, ephelis, dark skin, etc., and having improved whitening and beautifying effect. CONSTITUTION:A cosmetic obtained by incorporating one or two or more selected from L-ascorbic acid having the ability to inhibit the action of tyrosinase or returning dark-colored oxidized form melanin to light-colored reduced form melanin and esters thereof with one or two or more selected from pyridoxine having the ability to inhibit the action of the tyrosinase and derivatives thereof, e.g. pyridoxal having aldehyde at the 4-position, at 1:10-10:1 compounding weight ratio. Preferably, >=0.001wt%, particularly about 10wt%, based on the cosmetic, L-ascorbic acid and >=0.001wt%, particularly about 5wt%, based on the cosmetic, pyridoxine are incorporated therein.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel cosmetic with significantly improved whitening effects.

Cosmetics containing skin whitening agents are mainly used to whiten sunburned skin, which causes blemishes and freckles, and are of great interest to consumers among cosmetics.

Biascoric acid inhibits the action of tyrosinase, which generates melanin from tyrosine, and also has the effect of returning the dark oxidized melanin to the light reduced melanin, resulting in skin whitening, age spots, and It is well known that it is an effective compound for the treatment and improvement of buckwheat melasma, melasma, etc.; however, it is extremely unstable to heat and light and easily oxidized, and is especially effective against cosmetics containing water. It easily decomposes in food and tends to cause coloring. Therefore, for the purpose of stabilizing ascorbic acid, it has been proposed to blend ascorbic acid as an ester of higher fatty acids or phosphoric acid, or to add an antioxidant or reducing agent. The more stabilized the skin whitening effect, the less the whitening effect becomes.

In view of these circumstances, the present inventors have conducted intensive research to obtain cosmetics with truly excellent whitening effects, and have found that pyridoxine or its derivatives have the ability to inhibit the action of tyrosinase, which generates melanin from tyrosine. Its inhibitory effect can be enhanced by using it in combination with L-ascorbic acid or its derivatives, and it can reduce age spots, freckles,
It was discovered that dark skin and the like were significantly improved, and the present invention was completed based on these findings.

That is, the present invention provides one or more selected from the group consisting of L-ascorbic acid and its esters, one selected from the group consisting of pyridoxine and its derivatives, or two or more CJ-1- It is a whitening cosmetic product characterized by containing the following.

Next, the configuration of the present invention will be described.

L-ascorbic acid used in the present invention is generally referred to as vitamin C, and its strong reducing action has a cellular respiration effect.
It has an enzyme activation effect, a collagen formation effect, and a melanin reduction effect. In addition, examples of L-ascorbic acid esters include L-ascorbic acid monostearate 1.
L-ascorbic acid monoalkyl esters such as L-ascorbic acid monopalmite-1. L-ascorbic acid such as ester derivatives, L-ascorbic acid dialkyl esters such as L-ascorbic acid distearate-1, L-ascorbic acid dipadermite, L-ascorbic acid dioleate, L-ascorbic acid syric acid ester Diester derivative, L-ascorbic acid tristearate, L
Examples include trialkyl esters such as -ascorbic acid trispalmitate and L-ascorbic acid triphosphate, and ascorbic acid triester FA conductors such as L-ascorbic acid triphosphate.

In the cosmetic composition of the present invention, two or more than two types are suitably selected and used from the group consisting of the above-mentioned L-ascorbic acid and its esters.

L-ascorbic acid or L-ascorbic acid ester is effective when incorporated in cosmetics at 0001% by weight or more, and about 10% by weight is sufficient to exhibit the effects of the present invention. Used in the present invention Vitamin B6 is generally referred to as vitamin B6, and is considered to be an anti-dermatitis factor and a growth promoting factor for microorganisms.

Examples include the basic pyridoxine and various salts thereof such as phosphate esters and hydrochlorides.

In the cosmetic 1s of the present invention, one or more of the above-mentioned pyridoxine and its derivatives are appropriately selected and used.

Pyridoxine or its derivatives are used during cosmetic ri.
The effect is obtained when the content is 1% by weight or more, and about 5% by weight is sufficient to exhibit the effects of the present invention.

The blending ratio of L-ascorbic acid or L-ascorbic acid ester and pyridoxine or its derivative is 1 by weight.
]0 to ]0:1 is preferred.

Oa, lower margin) In addition to the above-mentioned essential ingredients, the cosmetic of the present invention also contains ingredients that are usually included in cosmetics, such as ultraviolet absorbers, humectants,
Preservatives, surfactants, fragrances, pigments, and the like can be used in appropriate combinations within a range that does not impair the effects of the present invention.

Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The ingredients are in weight percent.

Note that the whitening effect is determined by the so-called tyrosinase activity inhibition rate, which is the rate of inhibiting the action of tyrosinase that produces the dark brown pigment melanin from Domi, and the skin whitening effect of cumulative application, and the results of usage tests such as the elimination of age spots and freckles. Judgment was made from two points.

Tyrosinase Activity Inhibition Experiment> A method in which tyrosinase, which is an intermediate of melanin, is produced by using L-domi as a substrate and acting on tyrosinase for 115 minutes at 25°C.Measurement method using an absorptiometer at a distance of 1'1 m. I went there. The reaction solution composition and determination method are shown below.

(Reaction solution composition) L-dopa O, 5 mg/ml 0.5 ml phosphate buffer (p)l-h8=) 0.9 m sample solution
0o5- Tyrosinase (massi, /l/-mu) (1mg/m)
0.05m1 (500unit/m/!) (Judgment) ◎: Tyrosinase inhibition rate '70% or more'20' 5° ~
7o% △: 20-50% ×: 2o1% or less Whitening effect test by cumulative application〉 (Test method) Test subjects suffering from dark skin, spots, freckles, etc., as 1 group ・One sample lotion applied morning and evening It was applied to the face every day for 3 months, and its whitening effect was examined after the 3rd month.

(Judgment criteria) Author: Effect: Pigmentation is almost invisible.

Effective: Very tingling.

Slightly effective: Slightly tingling.

Ineffective: No change.

(Judgment) ◎: 0 if the percentage of test subjects showing excellent response or efficacy (effective rate) is 80% or more. ×: 50% to 80%: Examples 1 to 3, comparison if 50% or less. Examples 1 to 3 will be described. A lotion having the composition shown in Table 1 was prepared, and its tyrosinase activity inhibiting effect and whitening effect upon cumulative application were investigated.

The manufacturing method was adjusted as follows. i.e. 95% ethyl alcohol]0, POE (20) Rau IJ /l/
Mix 0.5 liters of powder and fragrance, and then add 29 parts of glycerin and 1 part of propylene glycol to the mixture.
and citric acid 0.29. l-Ascorbic acid or its ester, and pyridoxine or its derivative were added, and the necessary amount of distilled water was added and mixed so that the total weight was 1007; (the following is the margin) Table 1 Table 1 As is clear from the above, the cosmetic of the present invention is a novel cosmetic with excellent whitening effects.

Example 4 Milk liquid A milky lotion was produced by a conventional method according to the following recipe.

(Weight %) Stearic acid 20 Setanol ] 0 Vaseline 30 Lanolin alcohol 20 Liquid paraffin 80 Squalane 3゜S-Rolol 507 2.0 Ascorbic acid-2-sulfate Na O,1 Pyridoxine
0.01p, 0. E, (1,0% Le) % Noor L=
-2.5 Triethanolamine 1゜Propylene glycol 5゜Fragrance Appropriate amount Preservative Appropriate amount Distilled water 7o39 Example 5 Nutritional cream A cream was produced by a conventional method according to the following recipe.0 (% by weight) Stearic acid 2 .0 Stearyl alcohol 70 Reduced lanolin 2-0 Squalane 50 Octyldodecanol 60 P, 0. E, (25 mol) Cetyl ether 30 Lipophilic glyceryl monostearate 2-0 Fragrance suitable
Amount Preservative Appropriate amount Propylene glycol 5.0 Ascorbic acid silicate ester 30 Ascorbic acid diolet 1-2-0 Pyridoxine hydrochloride 0.25 Pyridoxine 025 Distilled water 62.5 Example 6 Pack The pack was prepared in a conventional manner according to the following recipe. Manufactured.

(Weight %) Camerin '10.095 Curku 19.0 Propylene glycol 50 Calcium acetate 001 Uric acid 05 Asfulvic acid monopalmitate 0.005 Viridoxal 50 Fragrance 0.39 (Left below) Example 7 Lotion Follow the following formulation - A lotion was manufactured using a conventional method.

(% by weight) Ethanol 150 P, O, E, (20 mol) Oleyl 08 Alcohol ether 2-hydroxy-4-methoxy 01 Benzophenone citric acid 0.05 Sodium citrate 006 L-ascorbic acid 005 Pyridoxine 0005 Glycerin 50 Fragrance Ingredients Appropriate amount Preservative Appropriate amount Distilled water '78.935 The cosmetics obtained from Examples 4 to 7 were excellent in the tyrosinase activity inhibiting effect and also had an excellent whitening effect when applied cumulatively.

Patent applicant Shiseido Co., Ltd.

Claims (1)

[Claims] It is characterized by containing one or more selected from the group consisting of L-ascorbic acid and its esters, and one or more selected from the group consisting of pyridoxine and its derivatives. Cosmetics.