KR100581374B1 - Composition of cosmetics comprising effect of improving subdued skin color - Google Patents

Abstract

The present invention relates to a cosmetic composition having a skin color improving effect. In particular, the present invention relates to a cosmetic composition having excellent whitening effect by simultaneously containing a vitamin B mixture and having melamine production inhibition and exfoliation effect.

The present invention provides a cosmetic comprising a vitamin B (vitamin B) mixture in a dry weight of 0.01 to 10% by weight, the vitamin B mixture is thiamine (vitamin B1), niacin (niacin; vitamin B3), pantothenic acid (vitamin B5), pyridoxine (pyridoxine; vitamin B6) is selected from two or more.

Cosmetics containing the vitamin B mixture of the present invention exhibits a keratin exfoliation effect and melanin synthesis inhibitory effect at the same time, thereby improving the color of the dull skin.

Cosmetics, Vitamin B, Thiamine, Niacin, Patotonic Acid, Pyridoxine, Melamine Formation Inhibition, Exfoliation of Skin, Ointment for External Skin, Lotion, Essence

Description

Cosmetic composition having effect on improving dull skin color {COMPOSITION OF COSMETICS COMPRISING EFFECT OF IMPROVING SUBDUED SKIN COLOR}

[Industrial use]

The present invention relates to a cosmetic composition having a skin color improving effect. In particular, the present invention relates to a cosmetic composition having excellent whitening effect by simultaneously containing a vitamin B mixture and having melamine production inhibition and exfoliation effect.

[Prior art]

It is everyone's constant desire to have white, fair skin. The cause of the dullness, which is the change of skin color, can be discussed in many factors

Firstly, the dullness of the skin is mainly caused by accumulated fatigue, menstruation and constipation due to lack of sleep. At this time, the skin physiological phenomenon is pointed out such as a decrease in blood flow, accumulation of waste keratin and dryness. .

Second, human skin color is genetically determined according to the concentration and distribution of melanin in the skin, but is influenced by environmental or physiological conditions such as sun ultraviolet rays, fatigue and stress.

When blood flow decreases or dry and aging keratin remains on the skin, the above mentioned factors lower the brightness (L: black and white) and saturation (a, b: red yellow), resulting in dark and dull color. Roach LB Nursing, 7 (1), p48, 1997). This dark skin condition is difficult to solve the partial cause of the occurrence, it is possible to solve only when the overall improvement of the cause.

Human skin color is genetically determined by the concentration and distribution of melanin in the skin, but is also influenced by environmental or physiological conditions such as sun, ultraviolet light, fatigue and stress. Melanin is produced through a non-enzymatic oxidation reaction after the action of tyrosinase (tyrosinase), an amino acid, called tyrosinase to convert it into dopa and dopaquinone. However, the pathways by which melanin is made are known, but the mechanisms that drive melanin synthesis, the previous step in which tyrosinase works, are still unknown.

Conventionally, by combining substances having inhibitory activity against tyrosinase such as hydroquinone, ascorbic acid, kojic acid, glutathione, and the like in ointments or cosmetics, skin whitening or blemishes It has been used for the purpose of improving freckles, but its use is limited due to irritation to skin or poor product stability, and its effect is insignificant. This dark skin condition is difficult to solve the partial cause of the occurrence, it is possible to solve only when the overall improvement of the cause.

The color change of the skin and the optical analysis method of L (L = black & white: 0-100), a (red & green: 50-50), b (yellow & blue: 50-50) In addition to image analysis methods for analyzing skin images, methods by visual inspection are commonly used (William KP, et al, J. Am. Acad. Dermatol., 21 (6), p 1306, 1989). And Andreassi L. et al, JID., 106 (5), p1154, 1996).

Women are trying to overcome this phenomenon because they can't get makeup on dull skin or make it look lifeless, and cosmetics companies have released various cosmetic products using some exfoliation and moisturizing to remove skin dullness. However, the lack of a gross overall solution has not yet been satisfactory to consumers.

On the other hand, vitamins are generically referred to as a number of organic compounds necessary for the normal metabolic function of the body and are divided into fat-soluble and water-soluble. In the literature (Biochemistry, 2nd edition, Syryer, complete book of vitamins & minerals, Susan MS, 1975), the importance of vitamins in living organisms and diseases resulting from deficiencies have already been studied by many scientists. It is used a lot in. Especially the vitamin B group is thiamine (vitamin B1), riboflavin (vita B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (pyridoxine; vitamin B6), cyano It is known as cobalamin (cyanocobalamin; vitamin B12), each of which is closely linked to the metabolic process of the living body, when lacking will cause side effects such as physical and mental disorders, fatigue as well as menstrual metabolism.

Thiamine is represented by the following Chemical Formula 1, and is involved in carbohydrate metabolism in the form of thiamine pyrophosphate, and is known to cause berryri (beriberi) vaginal when insufficient.

[Formula 1]

Niacin is represented by the following Chemical Formula 2, and is converted to a form of niacinamide, which is known to control blood circulation and blood cholesterol concentration of NAD or nicotinamide dinucleotide (NADH).

[Formula 2]

Pantothenic acid, represented by the following formula (3), is a constituent that makes coenzyme A, which is very important for bioenzyme reactions.

[Formula 3]

Pyridoxine is represented by the following formula (4), and plays the role of maintaining a chemical balance between blood and tissue.

[Formula 4]

They are very closely related to the energy metabolism process of the living body, and also have water solubility characteristics that they are easy to excrete and have not been reported any side effects that accumulate in the living body.

Vitamin B or complexes thereof are widely used as additives in medicine, food, cosmetics, and the like, and in particular, US Patent 4,818,521, US Patent 5,441,725, US Patent 5,723,138, US Patent 5,425,954, US Patent 5,548,064, and the like. It is known that the water-soluble vitamin B group is mainly involved in the energy metabolism process in the living body, the conventional cosmetics have been used for the purpose of enhancing cell activity through energy metabolism activation. However, no attempt has been made to produce cosmetics that contain this vitamin B and have a skin whitening effect.

The present invention aims to provide a cosmetic having excellent stability and safety, and excellent melanin synthesis inhibitory effect while promoting the exfoliation, in consideration of the problems of the prior art.

[Means to solve the problem}

The present invention provides a cosmetic comprising a vitamin B (vitamin B) mixture in a dry weight of 0.01 to 10% by weight in order to achieve the above object.

The vitamin B mixture is selected from the group consisting of thiamine (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), and pyridoxine (vitamin B6).

The cosmetics have an effect of exfoliating the skin and inhibiting melanin synthesis.

Hereinafter, the present invention will be described in detail.

The present invention reveals that melanin biosynthesis metabolism inhibition and keratin exfoliation effect are excellent in addition to the effects of promoting the cellular activity by participating in the known bioenergy metabolism of thiamin, niacin, pantothenic acid and pyridoxine. In addition, the present invention has been completed by proving its effect in vitro and in vivo experiments using the same.

The present invention is a mixture of vitamin B group selected from the group consisting of thiamine, niacin, pantothenic acid, pyridoxine at an appropriate concentration, such as skin ointment or flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, pack, etc. It is added to cosmetics.

The addition of the vitamin B group mixture is preferably 0.01 to 10% by weight on a dry basis.

When the mixture is used alone or in combination, it is difficult to expect substantial efficacy under the above-mentioned concentration, and the above-mentioned effect affects the stability of the product, and it is difficult to expect the enhancement effect by the amount added.

This invention is demonstrated in detail from the following Example and a comparative example. However, the examples are only for illustrating the present invention and are not limited thereto.

EXAMPLE

Example 1

As shown in the composition ratios of Table 1 and Table 2, thiamine (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (pyridoxine; vitamin B6) alone or two species The above mixture was added to the culture medium of the rat melanoma cells (B-16 mouse melanoma cells) and tested for the whitening effect at the cellular level.

These vitamin B groups were added to the culture medium for culturing B-16 melanoma cells, cultured for 3 days, and then cells were trypsinized, removed from the culture vessel, centrifuged, and melanin was extracted. To this, 1 ml of a 1 N aqueous sodium hydroxide solution was added, boiled for 10 minutes to dissolve the melanin, and the absorbance was measured at 400 nm with a spectrophotometer. The amount of melanin produced was measured by the absorbance of a unit cell allowance (106 cells). The results are shown in Table 1 and Table 2.

TABLE 1

Inhibitory Effect of Thiamine, Niacin, Pantothenic Acid, and Pyridoxine on Melonogenesis by Concentration on B-16 Melanoma Cells

Mixing ratio (weight ratio) Application concentration (%) Inhibitory effect Thiamine Niacin Pantothenic Acid Pyridoxine One 0 0 0 0.01 - 0.10 + 1.00 + 10.00 + 0 One 0 0 0.01 - 0.10 + 1.00 + 10.00 + 0 0 One 0 0.01 + 0.10 + 1.00 ++ 10.00 ++ 0 0 0 One 0.01 + 0.10 + 1.00 ++ 10.00 ++

In Table 1,-has no inhibitory effect; + Has a very mild inhibitory effect; ++: weak inhibitory effect; +++: Significant inhibitory effect.

TABLE 2

Inhibitory Effects of Thiamine, Niacin, Pantothenic Acid, and Pyridoxine Mixtures on Melonogenesis by Concentration on B-16 Melanoma Cells

Mixing ratio (weight ratio) Application concentration (%) Inhibitory effect Thiamine Niacin Pantothenic Acid Pyridoxine 0.5 0.5 0 0 0.01 + 0.10 ++ 1.00 ++ 10.00 ++ 0.5 0 0.5 0 0.01 + 0.10 ++ 1.00 ++ 10.00 ++ 0.5 0 0 0.5 0.01 + 0.10 ++ 1.00 ++ 10.00 ++ 0 0.5 0.5 0 0.01 + 0.10 ++ 1.00 ++ 10.00 ++ 0 0.5 0 0.5 0.01 + 0.10 ++ 1.00 ++ 10.00 ++ 0.4 0.3 0.3 0 0.01 + 0.10 ++ 1.00 +++ 10.00 +++ 0.4 0.3 0 0.3 0.01 + 0.10 ++ 1.00 +++ 10.00 +++ 0 0.4 0.3 0.3 0.01 + 0.10 ++ 1.00 +++ 10.00 +++ 0.2 0.3 0.2 0.3 0.01 + 0.10 ++ 1.00 +++ 10.00 +++ 0.1 0.3 0.2 0.1 0.01 + 0.10 ++ 1.00 +++ 10.00 +++

In Table 2,-has no inhibitory effect; + Has a very mild inhibitory effect; ++: weak inhibitory effect; +++: Significant inhibitory effect.

In the results of Table 1 and Table 2, thiamine, niacin, pantothenic acid, and pyridoxine alone do not have a great effect, but when used in combination of two, it can be seen that there is excellent melanin production inhibition in proportion to the increase in concentration. have. Therefore, the present invention demonstrates that the present invention can be very usefully used for improving freckles and skin whitening.

Comparative Example 1

For each of thiamin, niacin, pantothenic acid and pyridoxine, the exfoliation promoting effect was measured and shown in Table 3 below.

The test subjects were 30 healthy men aged 20 to 40 years. Before application of the sample, the inner color of the upper arm of the test subject was measured with a chromameter (CR-200, manufactured by Minolta, Japan), and 10% dihydroxy acetone (DHA) was added to the hill top chamber (Hill). 0.4 ml) was added and adhered to the inside of the upper arm for 6 hours.

After 24 hours, the color of the brown colored area was measured by DHA to compare the color difference with that before the sample application.

Thereafter, while applying the sample twice a day, the degree of discoloration every day was measured with a chromameter to measure the time to recover the original skin color.

Keratin peeling rate was calculated by the following equation (1).

[Equation 1]

In the above equation, TT (turnover time) is the time taken to replace the existing keratin layer with a new keratin layer, and in this experiment, it is the time taken for the skin colored by DHA to be completely restored.

Table 3 Exfoliation Effect of Conventional Alpha Hydroxy Acids

division Application concentration (%) Turnover time (days) Keratin exfoliation rate (%) blank - 17.6 ± 3.2 - S.C.L. menstruum - 16.6 ± 5.6 5.6 glycolic acid 5.00 13.8 ± 4.5 21.6 Thiamine 0.01 15.9 ± 3.3 1.0 0.10 16.2 ± 4.1 8.0 1.00 14.5 ± 2.3 17.6 10.0 13.1 ± 1.7 25.6 Niacin 0.01 15.2 ± 2.4 1.4 0.10 16.4 ± 2.6 6.8 1.00 14.1 ± 1.6 19.9 10.0 13.5 ± 2.8 23.3 Pantothenic Acid 0.01 15.5 ± 2.1 1.2 0.10 16.7 ± 2.9 5.1 1.00 14.8 ± 4.6 15.9 10.0 13.1 ± 1.7 25.6 Pyridoxine 0.01 15.0 ± 3.4 1.5 0.10 16.2 ± 4.4 8.0 1.00 14.1 ± 1.8 20.0 10.0 13.5 ± 2.7 23.3

In Table 3, blank refers to a group that is not applied to the sample after staining with DHA,

SCL (simple cosmetic liquid) solvent is a solvent used to improve the applicability to the skin. It is a mixed solvent of water: ethanol: 1,3-butylene glycol in a weight ratio of 80: 15: 5 and the target sample (thiamine) in the exfoliation test. , Niacin, pantothenic acid, pyridoxine) were used in this solvent.

Example 2

The vitamin B mixture of Example 1 was measured in the same manner as in Comparative Example 1 to measure the exfoliation promoting effect and the results are shown in Table 4.

Table 4 Exfoliation Effect of Vitamin B Mixtures

Mixing ratio (weight ratio) Application concentration (%) Turnover time (days) Keratin exfoliation rate (%) Thiamine Niacin Pantothenic Acid Pyridoxine 0.5 0.5 0 0 0.01 15.9 ± 2.1 9.6 0.10 12.6 ± 3.4 28.4 1.00 11.6 ± 3.7 34.1 10.0 10.2 ± 3.4 42.0 0.5 0 0.5 0 0.01 15.3 ± 2.2 13.1 0.10 12.1 ± 3.3 31.3 1.00 11.1 ± 1.5 37.0 10.0 9.9 ± 2.9 43.8 0.5 0 0 0.5 0.01 16.1 ± 4.2 8.5 0.10 12.2 ± 2.4 30.7 1.00 11.5 ± 2.6 34.7 10.0 10.5 ± 1.2 40.3 0 0.5 0.5 0 0.01 15.7 ± 2.3 5.1 0.10 12.2 ± 4.3 30.7 1.00 11.4 ± 1.1 35.3 10.0 9.0 ± 3.1 48.9 0 0.5 0 0.5 0.01 15.3 ± 2.4 13.1 0.10 13.1 ± 1.4 25.6 1.00 11.4 ± 2.3 35.2 10.0 9.4 ± 2.4 46.6 0.4 0.3 0.3 0 0.01 14.2 ± 4.1 19.3 0.10 13.5 ± 2.7 23.3 1.00 10.5 ± 7.2 40.3 10.0 9.5 ± 4.3 46.0 0.4 0.3 0 0.3 0.01 13.2 ± 4.1 25.0 0.10 12.5 ± 2.3 29.0 1.00 10.1 ± 1.7 42.6 10.0 9.7 ± 1.2 44.9 0 0.4 0.3 0.3 0.01 14.2 ± 1.1 19.3 0.10 11.7 ± 2.5 33.5 1.00 9.7 ± 2.6 39.2 10.0 8.9 ± 2.2 49.4 0.2 0.3 0.2 0.3 0.01 14.2 ± 4.1 19.3 0.10 13.5 ± 2.3 23.3 1.00 10.1 ± 1.7 42.6 10.0 8.5 ± 3.5 51.7 0.1 0.3 0.2 0.1 0.01 13.2 ± 2.2 25.0 0.10 11.4 ± 3.1 35.2 1.00 9.2 ± 2.6 47.7 10.0 8.8 ± 3.6 50.0

In Table 4, all target samples were used by dissolving in SCL solvent of Comparative Example 1.

As shown in Table 3, thiamine (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), and pyridoxine (vitamin B6) are known as glycolic acid (glycolic acid), which is a known exfoliant even when used alone. Compared with glycolic acid), it showed relatively good exfoliation promoting effect, and the exfoliation effect gradually increased with increasing concentration.

In addition, as shown in Table 4, when thiamin (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), and pyridoxine (vitamin B6) are properly mixed and applied, the respective substances are used alone. Higher exfoliation effect was seen. It can be seen that this has a superior effect than the conventionally known glycolic acid when used in combination with these materials, and as a result, it has a marked synergistic effect when used in mixture.

Thus, the following formulations were prepared with a mixture of thiamin (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), and pyridoxine (vitamin B6) with excellent melanin production inhibitory effect.

Example 3

To prepare a skin external ointment by mixing the formulation as shown in Table 5, to the pigmentation inhibitory effect test by contrasting the skin color change by the method described in Reference Example 1 to the ointment described in Table 10, Chromameter Table 11 shows the effect of improving the color on the change of skin color.

TABLE 5

Skin ointment Parts by weight Vitamin B mixture (thiamine: niacin: pantothenic acid = 3: 3: 4 (weight ratio)                                              Diethyl sebatate braze polyoxyethylene oleyl-ether phosphate sodium benzoate sodium vaseline purified water 1.0                                                                                            8.0 5.0 6.0 Proper quantity remaining (up to 100)

Comparative Example 2

Except for the vitamin B mixture (thiamine: niacin: pantothenic acid = 3: 3: 4 (weight ratio)) in the formulation of Table 5 to prepare a skin external ointment in the same manner as in Example 3, and the ointment The pigmentation inhibitory effect test of Reference Example 1 was carried out, and the results are shown in Table 10, and the change in skin color with a chromameter (CR-200 manufactured by Minota, Japan) was tested and shown in Table 11.

Example 4

Essence was prepared by mixing the formulations shown in Table 6 below, and the essence was tested in the pigmentation inhibitory effect of Reference Example 1 described in Table 10 below, and the skin was chromatographed (CR-200 manufactured by Minota, Japan). Tests for changes in color are reported in Table 11.

TABLE 6

essence Parts by weight Vitamin B mixtures (thiamine: niacin: pantothenic acid = 3: 3: 4 (weight ratio))                                              Thickened Glycerin Pluylene Glycol Polyoxyethylene Cured Castor Oil Sodium Hyaluronate Aqueous Solution (1%) Ethanol Preservative Perfume Dye Purified Water 5.0                                                                                            0.05 10.0 10.0 1.0 5.0 5.0 appropriate amount remaining amount (up to 100)

Comparative Example 3

Except for the vitamin B mixture (thiamine: niacin: pantothenic acid = 3: 3: 4 (weight ratio)) in the formulation of Table 6 to prepare an esensor in the same manner as in Example 4, this essence as reference The pigmentation inhibitory effect test of Example 1 was performed, it is shown in Table 10, and the change of skin color was carried out with the chromatometer (CR-200 by Minota, Japan), and it was shown in Table 11

Example 5

A nutrition cream was prepared by mixing the formulations shown in Table 7 below, and the nutrition cream was subjected to the pigmentation inhibitory effect test of Reference Example 1 described in Table 10, and described in Chromatometer (CR-200, manufactured by Minota, Japan). Table 11 shows the test for the change of skin color.

TABLE 7

Nutrition cream Parts by weight Vitamin B mixtures (thiamine: pantothenic acid = 4: 6 (weight ratio))                                              Stearic acid Thickened glycerin Squalane 1,3-butylene glycol Polysorbate 60 Polyethylene glycol 1000 Cured anolin octyl Dodecanol sorbitan Stearate Triethanolamine Preservatives Flavors Colorant Water 2.0                                                                                            5.0 6.0 2.0 1.0 9.0 6.0 1.5 4.0 4.0 10.0 0.8 0.5 Load balance (up to 100)

Comparative Example 4

A nutrition cream was prepared in the same manner as in Example 5 except for the vitamin B mixture (thiamine: pantothenic acid = 4: 6 (weight ratio)) in the formulation of Table 7, and a reference to the nutrition cream was given as follows. The pigmentation inhibitory effect test was carried out, and it is shown in Table 10, and the change of skin color with the chromameter (CR-200 by Minota, Japan) was tested and it is shown in Table 11.

Example 6

A flexible lotion was prepared by mixing the formulations shown in Table 8 below, and the flexible lotion was subjected to the pigmentation inhibitory effect test of Reference Example 1 described in Table 10 below, and a chromameter (CR-200 manufactured by Minota, Japan) Table 11 shows the test for the change of skin color.

TABLE 8

Flexible lotion Parts by weight Vitamin B mixture (niacin: pyridoxine = 1: 1: weight ratio)                                              1,3-butylene glycol Thickened glycerin Hyaluronic acid Polyethylene oleyl ether Polyoxynylene hardened castor oil Ethanol Preservatives Fragrance Dye Purified water 5.0                                                                                            6.0 2.0 1.0 0.1 0.1 10.0 Appropriate Appropriate Appropriate Balance (up to 100)

Comparative Example 5

Except for the vitamin B mixture (niacin: pyridoxine = 1: 1 (weight ratio)) in the formulation of Table 8 to prepare a flexible lotion in the same manner as in Example 6, the pigment of Reference Example 1 to the flexible lotion The deposition inhibitory effect test was described in Table 10, and the change in skin color with a chromameter (CR-200 manufactured by Minota, Japan) was tested and described in Table 11.

Example 7

A nutritional lotion was prepared by mixing the formulations shown in Table 9 below, and the nutritional lotion was subjected to the pigmentation inhibitory effect test of Reference Example 1 shown in Table 10, and described in Chromatometer (CR-200, manufactured by Minota, Japan). Table 11 shows the test for the change of skin color.

TABLE 9

Nutrition lotion Parts by weight Vitamin B mixtures (thiamine: niacin: pyridoxine = 2: 4: 4 (weight ratio))                                              Cetanol Beeswax Concentrated glycerin Squalane 1,3-butylene glycol Polysorbate 60 Vaseline Dimethylpolysiloxane Ethanol Carboxypolymer Sorbanthesquioleate Triethanolamine Preservatives Flavors Colorant Purified Water 10.0                                                                                            0.05 1.0 0.5 4.0 6.0 4.0 1.0 2.0 2.0 3.0 0.3 0.3 0.3 appropriate quantity remaining (up to 100)

Comparative Example 6

A nutritional lotion was prepared in the same manner as in Example 7, except for the vitamin B mixture (thiamine: niacin: pyridoxine = 2: 4: 4 (weight ratio)) in the formulation of Table 9, and the nutritional lotion was referred to below. The pigmentation inhibitory effect test of Example 1 was carried out, it is shown in Table 10, and the change of skin color was carried out with the chromatometer (CR-200 by Minota, Japan), and it was shown in Table 11.

Reference Example

Two healthy adult males covered 4 perforated aluminum foils with 2 cm x 2 cm creepers on the upper arms of both arms, and then 120 mJ / ㎠ at a distance of 50 cm using an oriel solar simulator 1000W. Ultraviolet rays were irradiated with an amount of light.

After UV irradiation, the right arm of 20 test subjects was applied with a formulation containing a vitamin B mixture, the left arm was applied with the same formulation of the right arm without vitamin B, and one area of both arms was blank (without applying anything). blank).

After 4 weeks, the effect of inhibiting pigmentation was visually identified, and the criteria were evaluated in three stages: significant inhibitory effect, slight inhibitory effect, and no inhibitory effect.

In addition, the chromaticity (CR-200 manufactured by Minolta Co., Ltd.) was used to measure the whiteness (L; whiteness) of the skin color before the sample treatment, after the ultraviolet irradiation, and the application of the sample to change the skin color.

Skin color improvement was calculated by the following equation.

[Equation 2]

TABLE 10 Pigmentation Inhibition Effect

division Significant Inhibitory Effect (persons) Slight inhibitory effect (persons) No effect (persons) Example 3 4 12 4 Comparative Example 2 0 2 18 Example 4 12 8 0 Comparative Example 3 0 3 17 Example 5 13 5 2 Comparative Example 4 0 3 17 Example 6 10 7 3 Comparative Example 5 0 One 19 Example 7 7 7 6 Comparative Example 6 0 2 18

As can be seen from the table, each formulation containing a vitamin B mixture of two or more of thiamine, niacin, pantothenic acid, and pyridoxine showed at least 15 or more effects of slight inhibition of pigmentation.

[Table 11] Skin color improvement effect

division L before sample treatment L after ultraviolet irradiation 4 weeks after sample application % Improvement Example 3 67.25 ± 3.4 57.62 ± 3.7 63.45 ± 3.7 60.5 Comparative Example 2 67.25 ± 3.4 57.62 ± 3.7 59.21 ± 2.6 16.5 Example 4 67.25 ± 3.4 57.62 ± 3.7 64.78 ± 4.7 74.3 Comparative Example 3 67.25 ± 3.4 57.62 ± 3.7 58.21 ± 2.6 6.1 Example 5 67.25 ± 3.4 57.62 ± 3.7 66.45 ± 4.2 91.7 Comparative Example 4 67.25 ± 3.4 57.62 ± 3.7 59.82 ± 3.8 22.8 Example 6 68.25 ± 3.6 59.45 ± 1.2 63.76 ± 6.6 49.0 Comparative Example 5 68.25 ± 3.6 59.45 ± 1.2 60.12 ± 6.3 7.6 Example 7 68.25 ± 3.6 59.45 ± 1.2 64.21 ± 3.7 54.1 Comparative Example 6 68.25 ± 3.6 59.45 ± 1.2 61.38 ± 3.9 21.9

As shown in the table, the formulation containing the vitamin B mixture of two or more of thiamine, niacin, pantothenic acid and pyridoxine showed a significant skin color improvement effect of 45-91% in the application group of the sample after UV irradiation. .

Cosmetics containing the vitamin B mixture of the present invention exhibits a keratin exfoliation effect and melanin synthesis inhibitory effect at the same time, thereby excellent in improving the color of dull skin.

Claims (4)

In cosmetics that improve dull skin color, Dry weight of a vitamin B mixture selected from the group consisting of thiamine (vitamin B1), niacin (vitamin B3), pantothenic acid (vitamin B5), and pyridoxine (vitamin B6) Cosmetic composition containing 0.01 to 10% by weight. delete The method of claim 1, A cosmetic composition in which the cosmetics simultaneously exfoliate the skin and inhibit the melanin synthesis. The method of claim 1, The cosmetic composition is a cosmetic external ointment, flexible lotion, nourishing lotion, nourishing cream, massage cream, essence or pack.