JPH049325A - Beautifying and whitening cosmetic - Google Patents

Abstract

PURPOSE:To obtain a beautifying and whitening cosmetic, capable of eliminating, lightening the color or preventing blackening or pigmentation of the skin with ultraviolet light without any side effects such as skin irritation by combining an extract essence of a mycelial culture of Ganoderma lucidum Karst., and/or an extract essence thereof with a specific substance. CONSTITUTION:A beautifying and whitening cosmetic is obtained by blending mycelial culture of Ganoderma lucidum Karst. and/or an extract essence thereof with (B) one or more selected from ascorbic acid, retinol, pyridoxine, pantothenic acid, tocopherol, salts and derivatives thereof as an active ingredient. The amounts of the ingredients are preferably 0.1-20wt.% ingredient (A) expressed in terms of the extract essence and 0.1-10wt.% ingredient (B) based on the total amount of the cosmetic. The aforementioned cosmetic is capable of eliminating, lightening the color or preventing blackening or pigmentation of the skin such as liver-spot or ephelis with ultraviolet light and exhibiting excellent beautifying and whitening effects without any side effects such as irritancy by application thereof to the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a whitening cosmetic that eliminates skin darkening, age spots, freckles, and other skin pigmentation caused by ultraviolet rays, and prevents lightening of the skin.

Conventionally, whitening cosmetic compositions containing vitamin C and its derivatives, reducing agents, and thyronase activity inhibitors such as placenta extract are known. However, these conventional whitening cosmetics are made using cultured cells.
Although in vitro experiments have shown that it suppresses melanin production, when it is actually applied to the skin, it does not sufficiently remove pigmentation or lighten the skin, and there are problems with side effects such as irritation.

The present inventors have conducted extensive research in order to solve these problems and obtain a whitening cosmetic with excellent effects. As a result, the present applicant's research idea led to the discovery of the Mycelium mycelium culture and/or its extract (Japanese Unexamined Patent Application Publication No. 61-111), which was previously found to have excellent effects on skin moisturization and skin conditioning.
-091113) or in combination with a specific substance, it was found that the f2 effect was excellent in eliminating skin pigmentation and lightening the skin color without side effects such as skin irritation, and this led to the completion of the present invention. Ta.

The present invention provides: (a) a mushroom mycelium culture extract and/or an extract thereof; and (b) ascorbic acid and its derivatives, retinol and its derivatives, pyridoquinone and its derivatives, pantothenic acid and its derivatives, and tocopherol and its derivatives. The present invention provides a whitening cosmetic composition containing one or more ingredients selected from the group consisting of:

The Bamboo shoots mycelium culture and its extract to be blended as an active ingredient in the whitening cosmetic of the present invention are disclosed in the above-mentioned Japanese Patent Application Laid-open No. 6
1-091113, a whole culture concentrate obtained by liquid culturing the C. chinensis mycelium, a culture concentrate from which the mycelium has been separated, an isolated mycelium or a whole culture, a culture solution,
These concentrates include solvent extracts of isolated mycelia, which may be used alone or in combination.

That is, the Bamboo shoots mycelium culture is obtained by culturing the mycelium of the Bamboo shoots species in a liquid medium containing 0.2-IOW/V% glucose and 02-2% W/V wheat germ as essential components. Glucose and wheat germ used as the medium components may be any of L) as long as they are commonly available as medium components. The seed hyphae to be used may be any seed hyphae as long as they belong to the order Pygridium, which belongs to the Basidiomycetes, and the family Pyrophyceae.

After completion of the cultivation, the whole culture (mixture of mycelium and culture solution) or the culture solution from which the mycelium has been separated is concentrated, for example, at 40 to 50 °C under reduced pressure, and dried if necessary. Before or after the concentration to dryness, it is pulverized in accordance with a conventional method to obtain a L. chinensis mycelium culture for use in the cosmetic composition of the present invention.

Separation of mycelium from the culture can be carried out according to conventional methods such as filtration and centrifugation.

The separated mycelium generally has a spherical shape with a diameter of 1 to 5 mm, and this can also be dried, for example, at 40 to 50°C under reduced pressure, pulverized, and used as the cosmetic of the present invention as a culture of C. chinensis mycelium. It can be used for

As mentioned above, in the present invention, the whole culture, the culture solution from which the mycelium has been separated, a concentrate or dried product thereof, or a solvent extract of the separated mycelium or the dried product thereof can also be used.

As the extraction solvent, water, alcohol, chloroform, ether, ethyl acetate, benzene, hexane, and mixed solvents thereof can be used, but in the present invention, lower-hydric alcohols, polyhydric alcohols, or their It is preferable to use a water-containing solvent. Low-
Examples of the alcohol include alcohols having 1 to 3 carbon atoms, such as methanol, ethanol, propatool, etc. Ethanol is particularly preferable, and hydrous ethanol (
The moisture content is most preferably 10-80%, preferably 50-70%. Examples of the polyhydric alcohol include alcohols having 2 to 5 carbon atoms, such as ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, and glycerin, with butylene glycol being particularly preferred, and hydrous alcohols. However, 100% butylene glycol is most preferred.

For extraction, for example, 3
It is preferable to carry out the extraction using ~20 times (by weight), preferably 5 to IO times the amount of solvent at 10 to 80°C, preferably 20 to 30°C with stirring.

It is preferable that the amount of the C. chinensis mycelial culture blended in the whitening cosmetic of the present invention is 0.1% to 20% by weight as an extracted extract based on the total amount of the cosmetic. If the amount is less than 0.1% by weight, there will be no effect of lightening pigmentation, and if it exceeds 20% by weight, it will cause some irritation to the skin.

In addition, the other active ingredient of the cosmetic of the present invention is:
Ascorbic acid and its salts, also; its derivatives such as ascorbic acid alkyl esters, ascorbic acid phosphate esters, retinol and its salts or its derivatives such as retinol palmitate, vitamin oil, pyridoquinone and its salts, or its derivatives such as lauric acid ester, tripalmitic acid ester, pantothenic acid and its salts or its derivatives such as bantothenyl ethyl ether, tocopherol and its salts, or acetic acid ester, succinic acid ester, etc. Derivatives thereof can be mentioned, and these may be used alone or in combination of two or more kinds.

The amount of these substances in cosmetics is 0°1-1
Preferably it is 0% by weight. If the amount is less than 0.1% by weight, there will be no effect of lightening pigmentation, while if it exceeds 10% by weight, irritation will be strong.

Thus, the whitening cosmetic composition of the present invention can be prepared by combining the L. chinensis mycelium culture and/or its extract and the above-mentioned substances with other desired ingredients by a known method to prepare a lotion, cosmetic oil, cream, or milky lotion. It is manufactured in the form of , packs, powders, etc.

Other ingredients are not particularly limited, and may be used as appropriate depending on the type of cosmetic and within the range that does not impair its performance.
Known ingredients can be blended.

Next, the present invention will be explained in more detail with reference to experiments and examples.

Experiments Next, we will present the results of evaluating the effects of various active ingredients on eliminating pigmentation or lightening the color.

Experimental method: The hair of an English brown guinea pig was pricked and exposed to ultraviolet light (UVB intensity: I J /cm).
') was irradiated and pigmentation was obtained one week later. Next, samples prepared by dissolving various solvent-extracted extracts of C. chinensis mycelium culture and active ingredients such as retinol in ethanol were cumulatively applied to this site for 4 weeks. The degree of pigmentation of the area to which no specimen was applied (no application) was set as 0, and the degree of pigmentation was determined visually according to the degree of lightening according to the criteria shown below.

Judgment criteria: 0: No lightening or lightening of pigmentation l Slight lightening or lightening of pigmentation 2, Moderate lightening of pigmentation 3: Results in which significant lightening of pigmentation is observed are shown in Table 1 below.

As is clear from Table 1, in any case,
When the above-mentioned substances were used in combination, a more remarkable lightening of the pigmentation was observed compared to when each extract of the C. chinensis mycelium culture was used alone. During the test, no redness due to irritation was observed.

Example 1 (lotion) A lotion was manufactured according to the following formulation.

Ingredients Amount (wt%): Cyrilium mycelium culture-05 Ethanol extract Magnesium ascorbic acid phosphate 0.5 Chrycerin 60 Ethanol
8.0 Polyquine ethylene hydrogenated human oil 08 Methyl paraoquinobenzoate 005 Citric acid 005 Sodium citrate 007 Fragrance
01 Purified water
Glycerin, citric acid, sodium citrate, and ascorbic acid phosphate magnesium salt were dissolved in the remaining purified water. Separately, in ethanol, dry ethanol extract of C. chinensis mycelium culture, polyoxyethylene hydrogenated castor oil (60E, O,), methyl parabenzoate,
A perfume was dissolved, added to the purified aqueous solution, solubilized, and filtered to obtain a lotion.

Example 2 (cosmetic oil) A cosmetic oil was produced according to the following formulation.

Ingredients Formulation 1 [(wt%) Bamboo shoots mycelium culture 1.3-05 Butylene glycol extract Retinol 0.5 Cholesteryl stearate October Primrose oil
20 squalane
A cosmetic oil was obtained by uniformly dissolving other ingredients in the remaining squalano.

Example 3 (cream) A cream was manufactured according to the following formulation.

Ingredient combination! ! (Weight %) Ingredients (A) Tocopherol Saran Beeswax Setanol Stearate Myristate Isopropyl Lanolin Liquid paraffin Self-emulsifying monostearate Glyceryl Monostearate Polyoquine Ethylene sorbitan (20E, 0.) Paraoquino Yasukuchi, Propyl fragrant water absorption σQ Stonegrass Mycelial culture Ethanol Para-oquinobenzoate Methyl propylene glycol Fragrance 0.2 Purified water Remaining ingredients (A)
was dissolved by heating and maintained at 80°C. Separately, component (B) excluding fragrance was dissolved by heating and maintained at 80° C., and component (A) was added thereto with stirring and thoroughly mixed. The mixture was cooled while stirring, and then a fragrance was added and further cooled to obtain a cream.

Example 4 (emulsion) A milky lotion was produced according to the following recipe.

Ingredients Amount (wt%) Ingredient (A) Pantothenic acid, glycyrrhetinic acid, stearyl, liquid paraffin, petrolatum, beeswax, sesquioleic acid, solhitane (B), Glycyrrhiza mycelium culture, ethylene golicool extract, polyoquinoethylene oleyl ether (20E○), paraoxybenzoin Ethyl acid 0.2 Propylene glycol 5.0 Carboxyvinyl polymer 0.5 Potassium hydroxide
05 fragrance
0.2 Purified water The remaining component (A) was dissolved by heating at 80° C., and added to the separately dissolved component (B) excluding the fragrance (at 80° C.) with stirring, and thoroughly mixed. Then, the mixture was cooled without stirring, perfume was added, and the mixture was further cooled to obtain an emulsion.

Example 5 (pack) To manufacture a pack using the following recipe.

Ingredients Amount (wt%): Bamboo shoots mycelium culture 05 Ethanol extract Tocopherol acetate 05 Vinyl acetate/styrene copolymer 10.0 Polyvinyl alcohol I O,0 Solpizoto
50 titanium oxide
8,0 Kaolin 70
Ethanol 50 fragrance
20 Ethyl paraoxybenzoate 0.2 Purified water
The remainder of the ethanol extract of the Cinnamon mycelium culture, tocopherol acetate, fragrance, and ethanol were uniformly dissolved. This was added to a homogeneous mixture of vinyl acetate-styrene copolymer, polyvinyl alcohol, sorbitol, titanium oxide, and kaolin. To this, a solution in which paraoquinoamic acid and ethyl dizoate were uniformly dissolved in purified water was added and mixed uniformly to obtain a pack.

Example 6 (powder) Powder was manufactured according to the recipe.

Ingredients Quantity (wt%) Stonefish mycelium culture 1030% aqueous ethanol extract Pyridoquinone 02 Dextrin 95.5 Talc
2.0 decaglyceryl stearate 10 30 of C. chinensis mycelium culture
% water-containing ethanol extract, pyridoquinone, and decaglyceryl stearate were heated and dissolved, maintained at 70°C, and gradually added to the mixture of dextrin and talc with stirring to obtain a powder.

Effects of the Invention The whitening cosmetic of the present invention, when applied to the skin, eliminates, lightens, or prevents darkening or pigmentation of the skin caused by ultraviolet rays without side effects such as irritation, and is characterized by an excellent whitening effect.

Claims (1)

[Scope of Claims] 1. (a) Bamboo shoots mycelium culture and/or its extract, and (b) ascorbic acid and its salts or its derivatives, retinol and its salts or its derivatives, pyridoxine and its salts or its derivatives. 1. A whitening cosmetic comprising, as an active ingredient, one or more ingredients selected from the group consisting of derivatives, pantothenic acid and its salts or its derivatives, and tocopherol and its salts or its derivatives.