JP2010018545A - Active oxygen scavenger, and skin care preparation for external use, composition for oral cavity and food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an active oxygen scavenger highly safe to human health and having excellent effects, and to provide a composition such as a skin care preparation for external use and a composition for the oral cavity, and food, each compounded with such an active oxygen scavenger. <P>SOLUTION: The active oxygen scavenger is characterized by comprising, as active ingredient, an extract from at least one plant selected from the group consisting of Parkia speciosa, Chromolaena odoratum, Anacyclus pyrethrum DC., Ochrocarpus longifolius, Aganosma marginata G. Don, Tectona grandis, Wrightia tomentosa, Diospyros rhodocalyx Kurz, and Bouer Burmanica Griff. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an active oxygen scavenger. The present invention further relates to the use of the active oxygen scavenger, and more particularly to a skin external preparation, oral composition and food containing the active oxygen scavenger.

  Living organisms that perform aerobic respiration, including humans, adjust the energy required by taking oxygen in the air or water into the living body by breathing and metabolizing nutrients such as sugars, lipids, and proteins using oxygen. We are using. Oxygen used for respiration is a relatively stable substance, but it is routinely changed to active oxygen such as superoxide, hydroxy radical, or hydrogen peroxide with high reactivity through various reactions in vivo. To do. These active oxygens have a strong bactericidal action and are important substances involved in self-protection of living bodies. However, active oxygen is a substance that protects living organisms, but due to its high reactivity, it damages lipids, proteins, DNA, etc. in the body, causing vascular damage due to arteriosclerosis, induction of malignant tumors, etc. It has become.

In particular, since the skin is an organ that directly contacts the outside world, it is easily affected by external environmental factors such as ultraviolet rays, and it is known that various diseases are induced by the active oxygen generated thereby. For example, if the active oxygen persists excessively in the skin due to ultraviolet rays, radiation, etc., it reacts with unsaturated fatty acids of biological membrane phospholipids to produce lipid peroxides, and the generated lipid peroxides cause skin inflammation and edema , Eczema, atopic dermatitis, X-ray dermatitis, burns, trauma, sun dermatitis, contact dermatitis, atopic dermatitis, etc., as well as increased glycosaminoglycan, collagen fiber cross-linking and It is known that reduction, elastic fiber modification, etc. are induced, the elasticity of the skin is lost, and external changes such as wrinkles and slack occur, and the so-called aging phenomenon called photoaging is promoted.
In addition, in the oral cavity, bacterial defenses such as polymorphonuclear leukocytes and macrophages, which are one of the blood cell components, are mobilized against bacterial infection and invasion, and bacteria are eliminated. Collagenase is produced and released from leukocytes. Furthermore, polymorphonuclear leukocytes contribute to the bactericidal ability of tissues in small amounts, but active oxygen that produces and releases invading tissues in large amounts is produced and released, resulting in excessive production. It is known that oxygen induces destruction of collagen existing relatively in the surface layer such as epithelium and connective tissue of gingival tissue and exacerbation of local inflammation.

Although it is active oxygen that causes damage to the living body in this way, humans have a mechanism that prevents damage to tissues and organs in the body due to active oxygen. For example, the scavenging action of active oxygen itself by enzymes such as SOD (Super Oxide Dismutase) and catalase corresponds to the mechanism. However, since the expression level of these enzymes rapidly decreases with aging, the increase in damage due to active oxygen and the occurrence of diseases and injuries associated therewith become prominent. In addition, due to the increased exposure to ultraviolet rays in the modern living environment and the prevalence of chemical substances in the atmosphere due to exhaust gases and tobacco, the generation of excess active oxygen in the younger generation also causes normal in vivo This self-defense mechanism cannot be satisfied, and the occurrence of the injury and illness is increasing.
Conventionally, a substance having an action of scavenging active oxygen has been found, and its use as an active oxygen scavenger and its application have been studied. For example, the active oxygen scavenging effect of plant extracts such as rosemary extract and ginkgo biloba extract has been reported (see Patent Document 1 and Patent Document 2).
In today's society, where there is a problem of increased biological damage caused by active oxygen and the occurrence of diseases and injuries associated therewith, there is a need to find a substance that is even safer and has an excellent active oxygen scavenging action. Yes.

Japanese Patent No. 4061877 Japanese Patent No. 3463044

  An object of the present invention is to provide an active oxygen scavenger that is highly safe for human bodies and can exhibit excellent effects. Another object of the present invention is to provide an active oxygen scavenger that can be safely blended into various compositions and can exhibit excellent effects. Another object of the present invention is to provide a composition containing such an active oxygen scavenger, for example, an external preparation for skin, an oral composition, and a food.

As a result of intensive studies to achieve the above-mentioned problems, the present inventors have found that an extract of a specific plant has an excellent active oxygen scavenging action, and have completed the present invention.
Accordingly, the present invention includes Parkia speciosa (scientific name: Parkia speciosa), Chromolaena odoratum (scientific name: Anacyclus pyrethrum DC.), Okrocarpus longifolius (scientific name: Ochrocarpus longifolius) Selected from the group consisting of Aganosma marginata G.Don), Tectona grandis (scientific name: Tectona grandis), Leitia tomentosa (scientific name: Wrightia tomentosa), Diopyros rhodocalyx (scientific name: Diospyros rhodocalyx Kurz), and Bauer Burmanica Griff (scientific name: Bouer Burmanica Griff). The active oxygen scavenger is characterized in that it contains at least one plant extract as an active ingredient.
The above-mentioned active oxygen scavenger of the present invention can be blended in various compositions such as a skin external preparation, an oral composition, and a food.
Therefore, the present invention is further directed to a skin external preparation containing the active oxygen scavenger, an oral composition containing the active oxygen scavenger, and a food containing the active oxygen scavenger.

The active oxygen scavenger of the present invention contains an extract from a plant as an active ingredient, exhibits extremely high safety and exhibits an excellent active oxygen scavenging action. The active oxygen scavenger of the present invention can be used as it is in the form of a solvent extract from plants, or can be formulated into various dosage forms.
The active oxygen scavenger of the present invention is useful for preventing or reducing damages and diseases such as living bodies, skin, and oral cavity caused by active oxygen. The active oxygen scavenger of the present invention can also be easily blended into compositions such as external preparations for skin, oral compositions and foods. Therefore, according to the skin external preparation, oral composition and food containing the active oxygen scavenger of the present invention, the active oxygen scavenging action of the active oxygen scavenger of the present invention can be enjoyed, and these are attributed to the active oxygen. It can be used to prevent or reduce damage and diseases in the living body, skin and oral cavity.

  The active oxygen scavengers of the present invention include Parkia speciosa (scientific name: Parkia speciosa), Chromolaena odoratum (scientific name: Anacyclus pyrethrum DC.), Ocrocarpus longifolius (scientific name: Ochrocarpus longifolius) Marginata (scientific name: Aganosma marginata G.Don), Tectona grandis (scientific name: Tectona grandis), Leitia tomentosa (scientific name: Diospyros rhodocalyx Kurz), and Bauer Burmanica (scientific name: ff) An extract of at least one plant selected from the group, specifically, a solvent extract is contained as an active ingredient.

Parkia speciosa is a plant belonging to the genus Parchia, which has not been known to scavenge reactive oxygen. As a raw material for obtaining an extract of Parkia speciosa, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Bark is preferably used.
Chromolaena odoratum is a plant belonging to the genus Chromolaena, and its active oxygen scavenging action has not been known so far. As a raw material for obtaining an extract of Chromolaena odoratum, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Leaves are preferably used.
Anacyclus pyrethrum DC. Is a plant belonging to the genus Anarchis, Asteraceae. As the raw material for obtaining the extract of Anacyclus pyrethrum, its bark, root, rhizome, stem, flower, flower bud, bud, leaf, stem, stem skin, fruit (fruit), pericarp, seed, seed coat, etc. can be used However, rhizomes are preferably used.
Ochrocarpus longifolius is a plant belonging to the genus Ochrocarpus belonging to the family Hypericaceae, and its active oxygen scavenging action has not been known so far. As a raw material for obtaining an extract of Ochrocarpus longifolius, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Stem bark is preferably used.
Aganosma marginata G.Don is a plant of the genus Aganosuma, and its active oxygen scavenging action has not been known so far. Bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem skin, fruit (fruit), pericarp, seed, seed coat, etc. can be used as a raw material for obtaining an extract of Aganosma marginata G.Don However, leaves are preferably used.

Tectona grandis is a plant belonging to the genus Teakaceae, and its action for scavenging reactive oxygen has not been known so far. As a raw material for obtaining an extract of Tectona grandis, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Leaves are preferably used.
Wrightia tomentosa is a plant belonging to the genus Leitia, and has no known active oxygen scavenging action. As a raw material for obtaining the extract of Wrightia tomentosa, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Leaves are preferably used.
Diospyros rhodocalyx Kurz is a plant belonging to the genus Oysteraceae, and has no known active oxygen scavenging action. As a raw material for obtaining an extract of Diospyros rhodocalyx Kurz, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. may be used. Leaves are preferably used.
Bouer Burmanica Griff is a plant belonging to the genus Bauer and has no known active oxygen scavenging action. As raw materials for obtaining the extract of Bouer Burmanica Griff, its bark, root, rhizome, flower, flower bud, bud, leaf, stem, stem bark, fruit (fruit), pericarp, seed, seed coat, etc. can be used. Leaves are preferably used.
These plants originate mainly from Southeast Asia, and some of them are native or cultivated in Thailand, for example. These plant extracts are of very low toxicity.

In the extraction from the plant raw material, the raw material for extraction may be used as it is. However, considering the extraction efficiency, it is desirable to extract the raw material after processing such as chopping, drying, and grinding.
Extraction is performed with a solvent, and as the extraction solvent, at least one selected from a lower alcohol, a polyhydric alcohol, a low polarity solvent and a polar solvent can be used. Examples of lower alcohols include methanol, ethanol, propanol, and isopropyl alcohol; examples of polyhydric alcohols include glycerin and polyethylene glycol; examples of low polarity solvents include saturated hydrocarbons such as pentane, hexane, heptane, octane, nonane, and decane; Examples of the polar solvent include water, acetone, ethyl acetate, methyl acetate and the like. These extraction solvents may be used alone or in combination of two or more. For example, water, ethanol, or a mixture of water and ethanol (for example, water-containing ethanol) can be preferably used.
The ratio (mass) of the extraction raw material and the extraction solvent is generally 1: 1 to 1000, preferably 1: 1 to 100, more preferably 1: 1 to 20, and particularly about 1:10. desirable.

The extraction temperature is desirably about 5 ° C. to the boiling point of the extraction solvent. For example, it is convenient to perform the extraction at room temperature (about 5 to 30 ° C.). The extraction time is not particularly limited, but is preferably about 1 hour to 14 days.
Further, with respect to the extraction method, for example, immersion extraction with an extraction solvent at a temperature from about 5 ° C. to the boiling point of the extraction solvent can be mentioned, and the extraction can be performed under normal pressure. A stirring operation may be performed during the immersion. In addition, operations such as pressurization, heating, steam pressure, centrifugation, filtration, and pressing may be performed.
The extraction operation can be repeated with the raw material residue after the first extraction operation.
As a plant extract that is an active ingredient of the active oxygen scavenger of the present invention, it may be extracted from one kind of plant raw material, or two or more parts of one kind of plant may be used as an extraction raw material, Two or more kinds of plants may be mixed as an extraction raw material to perform an extraction operation, or two or more kinds of plant extracts may be mixed.

The plant extract thus obtained can be used as it is depending on the situation, or it can be concentrated or purified by a known means.
The plant extract can be used in various forms such as an active ingredient concentrate (eg, concentrated extract), paste, gel, solid dried product and / or diluted product. For example, the extract is directly vacuum (frozen) dried, concentrated under reduced pressure, then vacuum (frozen) dried, or concentrated under reduced pressure, and fractionated with various solvents to purify active oxygen scavenging components, The extract may be obtained by vacuum (freeze) drying, or by a concentration purification method using column chromatography in which an extract is loaded on the column and then vacuum (freeze) dried.
In addition, the process of obtaining said plant extract is also possible to select and use the thing of the shape according to the objective and a concentrated thing, stopping operation suitably in the middle process, without performing to the last drying process. . The extract obtained by the above extraction operation can be obtained by distilling off the solvent. However, in some cases, particularly when the extraction solvent is non-toxic water, ethanol or the like, the solvent can be distilled off. It is also possible to use the extract as it is.

The active oxygen scavenger of this invention is good also as a composition of the said plant extract single which is an active ingredient, and may contain another component other than this active ingredient.
The active oxygen scavenger according to the present invention can be prepared in various dosage forms. For example, it can be prepared in a desired form such as a solution obtained by dissolving a plant extract, which is an active ingredient of the active oxygen scavenger of the present invention, in an appropriate solvent, or a paste, powder, block or the like.
The active oxygen scavenger of the present invention can be used for compositions in a wide range of fields, and the present invention is particularly directed to external preparations for skin, oral compositions, and foods.
The external preparation for skin, composition for oral cavity, and food dosage form containing the active oxygen scavenger of the present invention are arbitrary, ampoules, capsules, powders, granules, tablets, solids, liquids, gels Various dosage forms such as a shape, paste, emulsion, cream, ointment, sheet, mousse, powder dispersion, and multilayer can be formed.

Specific examples of the external preparation for skin containing the active oxygen scavenger of the present invention include basic cosmetics such as lotions, beauty lotions, emulsions, creams, ointments, oils, packs, etc .; make-ups such as under make-up and foundation Skin care products such as soap, body shampoo, cleansing cream, cleansing lotion, cleansing milk, facial cleanser, etc .; shampoo, rinse, treatment, hair restorer, hair tonic, etc. Deodorants such as inhibitors; sanitary articles such as sanitary swabs and wet tissues.
In the external preparation for skin of the present invention, the amount of the plant extract, which is an active ingredient of the active oxygen scavenger, is suitably 0.001 to 50% by mass, particularly 0.01 to 20% by mass of the whole composition. Is desirable.
In the external preparation for skin of the present invention, other active oxygen scavengers other than the above active oxygen scavengers may be used in combination.

In the external preparation for skin of the present invention, various components usually used in external preparations for skin such as cosmetics and quasi drugs can be appropriately blended.
Examples of humectants include glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, polyglycerin, polyethylene glycol and other polyhydric alcohols, amino acids, NMF components such as sodium pyrrolidonecarboxylate, hyaluronic acid, collagen And water-soluble polymer substances such as mucopolysaccharide and chondroitin sulfate. Examples of the thickener include sodium alginate, xanthan gum, hydroxyethyl cellulose, carrageenan, carboxyvinyl polymer, cationized cellulose, polyvinyl alcohol, metal soap and the like. Examples of the oils and fats include vegetable oils such as castor oil, olive oil, cacao oil, camellia oil, jojoba oil, and avocado oil, and animal oils such as mink oil and egg yolk oil. Other waxes include beeswax, beeswax, lanolin, carnauba wax, candelilla wax and the like. Examples of hydrocarbons include liquid paraffin, liquid isoparaffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petrolatum and the like.

Examples of fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid and the like. Examples of higher alcohols include cetanol, stearyl alcohol, hexyl decanol, 7-octitodecanol, and lauryl alcohol. Examples of the esters include isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, isocetyl myristate, octyldodecyl oleate, and cholesterol ester.
Surfactants include non-lipophilic or self-emulsifying glycerin monostearate, polyglycerin fatty acid ester, sorbitan fatty acid ester, higher alcohol ethylene oxide adduct, polyoxyethylene (POE) sorbitan fatty acid ester, POE hydrogenated castor oil, etc. Examples include ionic surfactant, fatty acid potassium salt, fatty acid sodium salt, fatty acid triethanolamine salt, cationic surfactant such as POE alkyl ether sulfate sodium salt, and amphoteric surfactant such as lecithin and alkylaminoethylglycine hydrochloride. .

Examples of the ultraviolet absorber and the scattering agent include 2-hydroxy-4methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycynate, titanium oxide, zinc oxide, kaolin, talc and the like. Examples of the preservative include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, triclosan, triclocarban, benzalkonium chloride, hinokitiol, phenoxyethanol and the like. Examples of nutrients include vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, and the like, which can be appropriately mixed. In addition, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, plant extracts, various types Crude drugs, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts, whitening agents such as vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, glucose, fructose, mannose, sucrose, trehalose, etc. These saccharides and amino acids can also be appropriately blended. Moreover, ethanol, water, etc. are mentioned as pH adjusters like potassium hydroxide and a solvent.
The skin external preparation of the present invention can be produced according to a conventional method according to its form and shape, and the above-described plant extract may be blended in an appropriate production process.

The composition for oral cavity containing the active oxygen scavenger of the present invention is a dentifrice, liquid dentifrice, liquid dentifrice, toothpaste such as powder dentifrice, oral ointment, mouth freshener, mouthwash, mouthwash, It can be provided in various forms such as mouthwash, mouthwash, oral gel, oral paste, oral spray, film, troche, tablet, chewable, chewing gum and the like.
In the composition for oral cavity of the present invention, the amount of the plant extract as the active ingredient of the active oxygen scavenger is generally 0.001 to 20% by mass, preferably 0.01 to 20% by mass of the whole composition. It is 10 mass%, More preferably, it is the range of 0.1-10 mass%.
In the composition for oral cavity of this invention, you may use together other active oxygen scavengers other than said active oxygen scavenger.

In the oral composition of the present invention, various components that are usually used in oral compositions can be appropriately blended.
For example, as a polishing agent, silica-based polishing agent such as silica gel, precipitated silica, ignitable silica, zeolite, anhydrous silicic acid, hydrous silicic acid, aluminosilicate, zirconosilicate, zeolite, dicalcium phosphate dihydrate, Anhydrous dibasic calcium phosphate, tribasic magnesium phosphate, tribasic calcium phosphate, heavy calcium carbonate, light calcium carbonate, zirconium silicate, calcium pyrophosphate, insoluble sodium metaphosphate, aluminum oxide, resin, alumina, synthetic resin abrasive, etc. When the abrasive is used, it is generally blended in the range of 10 to 60% by mass of the oral composition.
Binders include sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, calcium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, ammonium alginate, alginic acid and its derivatives, carrageenan (ι, λ, κ), xanthan gum , Guar gum, gum arabic, gelatin, agar, sodium polyacrylate, polyvinyl alcohol, etc., and when a binder is used, it is generally blended in the range of 0.1 to 5% by mass of the oral composition. Is. Examples of the thickener include polyethylene glycol, sorbitol, glycerin, propylene glycol and the like. When these are used, they are generally blended in the range of 10 to 40% by mass of the oral composition.

Blowing agents include sodium lauryl sulfate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-lauroyl sarcosine sodium, N-acyl glutamate and other N-acyl glutamates, sodium alkyl sulfonates , 2-maltitol fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, etc. In general, it is blended in the range of 0.1 to 5% by mass of the oral composition.
The amount of these additives can be appropriately adjusted according to the properties of the intended preparation.
Examples of the wetting agent include glycerin, concentrated glycerin, diglycerin, sorbitol, maltitol, dipropylene glycol, propylene glycol, 1,3-butylene glycol, xylitol, and polyethylene glycol.

  1-menthol, carvone, eugenol, anethole, cineol, ethyl butyrate, limonene, menthone, methyl salicylate, thymol, cinnamix K aldehyde, trans-2-hexenal, fatty acid ester, terpene hydrocarbon, phenol ether, aldehyde, ketone Fragrance ingredients such as lactone, and saccharin sodium, aspartame, palatinose, isomaltose, coupling sugar, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perlartin, trehalose, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone Sweeteners such as peppermint and spearmint, methylparaben, butylparaben, paraoxybenzoate Antiseptics, antibacterial agents (such as growth inhibitors against periodontopathic or carious bacteria such as P. gingivalis bacteria, S. mutans bacteria, S. sobrinus bacteria, etc.), anti-cariogenic agents, anti-inflammatory agents, whitening agents, Moisturizers, antioxidants, oily components, thickeners, alcohols (such as ethanol), amino acids, powder components, colorants, aqueous components, water and the like can be appropriately blended as necessary. In addition to the above ingredients, chlorhexidine hydrochloride, chlorhexidine salts, cetylpyridinium chloride, triclosan, isopropylmethylphenol, tocopherol acetate, benzalkonium chloride, benzethonium chloride, ε-aminocaproic acid, tranexamic acid, pisabolol, which are active ingredients of oral compositions Sorbic acid, hinokitiol, mutanase, sodium monofluorophosphate, dextranase, sodium fluoride, stannous fluoride, lysozyme chloride, glycyrrhetinic acid, glycyrrhizinate such as dipotassium glycyrrhetinate, lytic enzyme, mutanase, Sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine salt, aluminum hydroxyl allantoin, Diazulene sulfonate, pyridoxine chloride, vitamin E, ascorbic acid, ascorbates, medicinal hydroxyapatite, sodium monofluorophosphate, sodium fluoride, potassium fluoride, stannous fluoride, water-soluble primary or secondary Diphosphates, quaternary ammonium compounds, hydroxycholesterol, polyethylene glycol, polyvinylpyrrolidone, sodium chloride, and the like can also be blended.

  The composition for oral cavity of the present invention can be produced according to a conventional method according to its form and shape, and the above-mentioned plant extract may be blended in an appropriate production process.

The food containing the active oxygen scavenger of the present invention is not particularly limited, and examples thereof include various food forms such as chewing gum, candy, candy, gummy candy, tablet, and powdered juice.
The food of the present invention can be produced by appropriately blending ingredients according to the properties of the target food together with the above-described plant extract. Examples of ingredients used in the production of the above food include sweeteners such as gum base, sugar, isomaltose, maltose, corn syrup, starch syrup, palatinose, maltose, flavors, gums such as gum arabic, gelatin, excipients, etc. Is mentioned.
In the food of the present invention, the amount of the plant extract, which is an active ingredient of the active oxygen scavenger, is suitably 0.001 to 10% by mass, particularly 0.01 to 1% by mass of the whole composition. It is desirable.
In the foodstuff of this invention, you may use together other active oxygen scavengers other than said active oxygen scavenger.

EXAMPLES Next, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.
<Example 1>
10 g of 70 v / v% ethanol was added to 1 g of a pulverized dried bark of Parkia speciosa and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 2>
10 g of 70 v / v% ethanol was added to 1 g of the pulverized dried leaf of Chromolaena odoratum and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 3>
10 g of 70 v / v% ethanol was added to 1 g of the ground, rhizome and dried stem product of Anacyclus pyrethrum DC and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 4>
10 g of 70 v / v% ethanol was added to 1 g of pulverized dried Ochrocarpus longifolius peel and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.

<Example 5>
10 g of 70 v / v% ethanol was added to 1 g of the pulverized dried product of Aganosma marginata G. Don, and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 6>
10 g of 70 v / v% ethanol was added to 1 g of the ground leaf dried product of Tectona grandis and extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 7>
10 g of 70 v / v% ethanol was added to 1 g of the pulverized dried Wrightia tomentosa leaf, and the mixture was extracted overnight at room temperature (25 ° C.). The supernatant was recovered and sterilized by filtration through a 0.22 μm filter to obtain an extract.
<Example 8>
10 g of 70 v / v% ethanol was added to 1 g of the pulverized dried Diospyros rhodocalyx leaf and extracted overnight at room temperature (25 ° C.). The supernatant was collected and sterilized by filtration through a 0.22 μm filter to obtain an extract <Example 9>
10 g of 70 v / v% ethanol was added to 1 g of the ground pulverized product of Bouer Burmanica Griff and extracted overnight at room temperature (25 ° C.). The supernatant was collected and sterilized by filtration through a 0.22 μm filter to obtain an extract.

<Test example>
Antioxidation test using active oxygen scavenging ability as an index For the plant extracts obtained in the above examples, SOD-like activity was measured using a SOD Assay kit-WST (manufactured by Dojindo Laboratories) in a 96-well plate. It was measured. The reagent included in the kit was used. After adding 20 μL of the sample solution to each well, 200 μL of WST working solution was added and well stirred with a plate mixer. 20 μL of Dilution buffer was added to the blank well. 20 μL of Enzyme working solution was added to each well containing the sample solution and blank wells. Then, it incubated at 37 degreeC for 20 minute (s), and the light absorbency in 450 nm was measured with the plate reader. The concentration (%) of each extract when the active oxygen elimination rate was 50% was determined as an IC50 value.
For comparison, operation was performed in the same manner as described above using a rosemary extract which has been conventionally said to have a high antioxidant effect among plant extracts. The rosemary extract is a commercially available rosemary extract (manufactured by Maruzen Pharmaceutical Co., Ltd.).
The results are shown in Table 1 below. It has been found that the plant extract as an active ingredient of the active oxygen scavenger of the present invention has an excellent active oxygen scavenging action and an antioxidant action based on the active oxygen scavenging ability.

Below, the formulation example of the skin external preparation of this invention, the composition for oral cavity, and foodstuffs which mix | blended various plant extracts and was prepared by the conventional method is shown. The unit of the amount is mass%.
<Example 10>
Lotion ethanol 5%
Glycerin 3%
Dipropylene glycol 2%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Methylparaben 0.2%
10% plant extract obtained in Example 1
Purified water remaining
Total 100%

<Example 11>
Lotion polyethylene (20) Polyoxypropylene (4)
Cetyl ether 3%
Polyethylene glycol 1000 2%
Ethanol 1.5%
1,2-pentadiol 1%
Polyoxyethylene (60) hydrogenated castor oil 0.2%
Hydroxypropyl methylcellulose 0.12%
Citric acid (10% aqueous solution) 0.1%
Sodium citrate (10% aqueous solution) 0.6%
3% plant extract obtained in Example 2
Purified water remaining
Total 100%

<Example 12>
Lotion ethanol 8%
Sorbit solution 2%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Phenoxyethanol 0.5%
Macadamia nut oil 0.1%
Sodium lactate (50% aqueous solution) 0.12%
Lactic acid 0.01%
Edetate disodium 0.02%
The plant extract obtained in Example 3 0.3%
Purified water remaining
Total 100%

<Example 13>
Lotion ethanol 10%
1,3-butylene glycol 6%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Partially hydrogenated horse oil 0.1%
Dipropylene glycol 2%
Citric acid appropriate amount Sodium citrate appropriate amount Plant extract obtained in Example 4 5%
Purified water remaining
Total 100%

<Example 14>
Lotion
1,3-butanediol 19%
Squalane 11%
Polyoxyethylene (60) hydrogenated castor oil 8.1%
Tri (Capryl, Caprin) Glycerin 5.5%
Decaglyceryl monolaurate 7.4%
Jojoba oil 1.8%
Fragrance 0.5%
The plant extract obtained in Example 5 0.1%
Purified water remaining
Total 100%

<Example 15>
Lotion ethanol 4%
Glycerin 3%
Dipropylene glycol 2%
Polyoxyethylene (60) hydrogenated castor oil 0.6%
Methylparaben 0.1%
15% plant extract obtained in Example 6
Purified water remaining
Total 100%

<Example 16>
Lotion ethanol 5%
Glycerin 3%
Dipropylene glycol 2%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Methylparaben 0.2%
The plant extract obtained in Example 7 0.1%
Purified water remaining
Total 100%

<Example 17>
Lotion ethanol 5%
Glycerin 3%
Dipropylene glycol 2%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Methylparaben 0.2%
0.1% of plant extract obtained in Example 8
Purified water remaining
Total 100%

<Example 18>
Lotion ethanol 5%
Glycerin 3%
Dipropylene glycol 2%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Methylparaben 0.2%
0.1% plant extract obtained in Example 9
Purified water remaining
Total 100%

<Example 19>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenoxyethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 1
Purified water remaining
Total 100%

<Example 20>
Latex carboxyl vinyl polymer (1% aqueous solution) 10%
Glycerin 3.5%
Dipropylene glycol 1.5%
Tri (capryl, caproic acid) glycerin 1%
Octyldodecyl myristate 1%
Squalane 0.5%
Hydrogenated soybean phospholipid 0.4%
Phenoxyethanol 0.3%
Tocopherol acetate 0.1%
Methylparaben 0.1%
10% plant extract obtained in Example 2
Purified water remaining
Total 100%

<Example 21>
Latex liquid paraffin 10%
1,3-butylene glycol 5%
Isostearyl alcohol 4.5%
Partially hydrogenated horse oil 2%
Polyoxyethylene (20) behenyl ether 1.6%
Tetraoleic acid polyoxyethylene (60) sorbit 1.5%
Lipophilic glyceryl monostearate 1.2%
Diglyceryl sesquiisostearate 0.4%
Sodium hydroxide proper amount 3% of plant extract obtained in Example 3
Purified water remaining
Total 100%

<Example 22>
Latex chicken (capryl, caproic acid) glycerin 8%
Polyglyceryl monolaurate 2.8%
Squalane 2%
Partially hydrogenated horse oil 2%
Diglyceryl monooleate 0.7%
Jojoba oil 0.5%
Liquid paraffin 0.3%
Lipophilic glyceryl monostearate 0.2%
The plant extract obtained in Example 4 0.1%
Purified water remaining
Total 100%

<Example 23>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenoxyethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 5
Purified water remaining
Total 100%

<Example 24>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenoxyethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 6
Purified water remaining
Total 100%

<Example 25>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenocosi ethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 7
Purified water remaining
Total 100%

<Example 26>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenoxyethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 8
Purified water remaining
Total 100%

<Example 27>
Emulsion xanthan gum (1% aqueous solution) 10.0%
Liquid paraffin 8.0%
1,3-butylene glycol 6%
Plant squalane 3.0%
Isocetyl myristate 2.0%
Polyoxyethylene (20) behenyl ether 1.2%
Polyoxyethylene tetraoleate (60) sorbit 1.2%
Lipophilic glyceryl monostearate 1.0%
Cetostearyl alcohol 0.5%
Phenoxyethanol 0.5%
Potassium hydroxide (10% aqueous solution) 0.47%
Methylparaben 0.1%
Propylparaben 0.1%
Carboxy vinyl polymer 0.1%
10% plant extract obtained in Example 9
Purified water remaining
Total 100%

<Example 28>
Toothpaste calcium hydrogen phosphate 40%
Silicic anhydride 5%
Glycerin 20%
Sodium carboxymethylcellulose 2%
Sorbit solution 10%
Fragrance 1%
Sodium lauryl sulfate 0.1%
Paraoxybenzoate 0.2%
Sodium fluoride 0.2%
The plant extract obtained in Example 1 0.1%
Purified water remaining
Total 100%

<Example 29>
Toothpaste aluminum hydroxide 35%
Glycerin 20%
Crystalline cellulose 10%
Polyethylene glycol 10%
Hydroxypropylcellulose 2%
Fragrance 1%
Sodium lauryl sulfate 0.1%
Butylparaben 0.2%
Saccharin sodium 0.1%
Tocopherol acetate 0.1%
Cetylpyridinium chloride 0.05%
The plant extract obtained in Example 2 0.3%
Purified water remaining
Total 100%

<Example 30>
Toothpaste calcium carbonate 25%
Sorbit solution 15%
Concentrated glycerin 10%
Silicic anhydride 5%
Sodium carboxymethylcellulose 2%
Fragrance 1%
Sodium lauryl sulfate 0.5%
Saccharin sodium 0.05%
5% plant extract obtained in Example 3
Purified water remaining
Total 100%

<Example 31>
Toothpaste Concentrated Glycerin 30%
Calcium pyrophosphate 25%
Silicic anhydride 5%
Sodium carboxymethylcellulose 1%
Fragrance 1%
Sodium lauryl sulfate 0.5%
Saccharin sodium 0.05%
Benzethonium chloride 0.05%
The plant extract obtained in Example 4 0.5%
Purified water remaining
Total 100%

<Example 32>
Toothpaste silicic acid 20%
70% sorbite solution 20%
Glycerin 20%
Propylene glycol 3%
Sodium lauryl sulfate 1.7%
Polyethylene glycol 1%
Carrageenan 1%
Fragrance 1%
Titanium dioxide 0.5%
Sodium lauryl sarcosine 0.3%
Methyl paraoxybenzoate 0.2%
DL-α-Tocopherol 0.1%
Copper chlorofin sodium 0.05%
Cetylpyridinium chloride 0.05%
1% plant extract obtained in Example 5
Purified water remaining
Total 100%

<Example 33>
Toothpaste aluminum hydroxide 30%
Glycerin 20%
Sodium chloride 10%
Silicic anhydride 5%
Polyoxyethylene hydrogenated castor oil 3%
Sodium lauryl sulfate 1.8%
Sodium carboxymethylcellulose 1%
Polyethylene glycol 1%
Fragrance 1%
Paraoxybenzoate 0.2%
Tocopherol acetate 0.1%
DL-α-Tocopherol 0.1%
Isopropyl methylphenol 0.02%
The plant extract obtained in Example 6 0.2%
Purified water remaining
Total 100%

<Example 34>
Toothpaste calcium pyrophosphate 32%
Glycerin 25%
Silica anhydride 6%
Sodium carboxymethylcellulose 1%
Glycyrrhetinic acid 1%
Polyethylene glycol 1%
Fragrance 0.1%
ε-Aminocaproic acid 0.1%
DL-α-Tocopherol 0.1%
Isopropyl methylphenol 0.02%
Plant extract obtained in Example 6 0.5%
Purified water remaining
Total 100%

<Example 35>
Toothpaste
70% sorbite solution 30%
Silica anhydride 10%
Glycerin 10%
Xanthan gum 1%
Xylitol 1%
Polyethylene glycol 1%
Fragrance 0.5%
Sodium dihydrogen phosphate dihydrate 0.3%
DL-α-Tocopherol 0.1%
Ethyl paraoxybenzoate 0.1%
Butyl paraoxybenzoate 0.05%
Sodium hydroxide 0.05%
0.1% of plant extract obtained in Example 8
Purified water remaining
Total 100%

<Example 36>
Toothpaste Concentrated Glycerin 20%
Calcium pyrophosphate 16%
Silica anhydride 7%
Fragrance 1%
Sodium carboxymethylcellulose 0.8%
Sodium lauryl sulfate 0.6%
Carrageenan 0.6%
Lysozyme chloride 0.4%
Stevia extract 0.1%
Triclosan 0.1%
Chlorhexidine gluconate 0.05%
The plant extract obtained in Example 9 0.2%
Purified water remaining
Total 100%

<Example 37>
Liquid dentifrice ethanol 2%
Agar 1.5%
Polyoxyethylene hydrogenated castor oil 1.5%
Fragrance 0.4%
Paraoxybenzoic acid ester 0.1%
Saccharin sodium 0.05%
1% plant extract obtained in Example 1
Purified water remaining
Total 100%

<Example 38>
Liquid dentifrice aluminum hydroxide 10%
Glycerin 10%
Polyoxyethylene hydrogenated castor oil 0.5%
Carrageenan 0.5%
Ethanol 0.5%
Fragrance 0.4%
Paraoxybenzoic acid ester 0.1%
Saccharin sodium 0.05%
Plant extract obtained in Example 2 0.5%
Purified water remaining
Total 100%

<Example 39>
Liquid dentifrice glycerin 20%
Polyethylene glycol 10%
Silica anhydride 3%
Calcium hydrogen phosphate 2%
Sodium carboxymethylcellulose 2%
Polyoxyethylene hydrogenated castor oil 1%
Aluminosilicate 0.5%
Fragrance 0.5%
Paraben 0.1%
3% plant extract obtained in Example 3
Purified water remaining
Total 100%

<Example 40>
Liquid dentifrice glycerin 10%
Aluminum hydroxide 10%
Agar 1%
Ethanol 0.5%
Polyoxyethylene hydrogenated castor oil 0.5%
Carrageenan 0.5%
Fragrance 0.4%
Paraoxybenzoic acid ester 0.1%
10% plant extract obtained in Example 4
Purified water remaining
Total 100%

<Example 41>
Liquid dentifrice glycerin 25%
Sorbit solution 25%
Xanthan gum 1%
Sodium carboxymethylcellulose 0.5%
Fragrance 0.5%
Polyoxyethylene hydrogenated castor oil 0.5%
Sodium lauryl sulfate 0.5%
Paraoxybenzoic acid ester 0.1%
The plant extract obtained in Example 5 0.2%
Purified water remaining
Total 100%

<Example 42>
Liquid dentifrice
70% sorbite solution 30%
Silica anhydride 10%
Glycerin 10%
Xanthan gum 1%
Xylitol 1%
Fragrance 0.5%
Ethyl paraoxybenzoate 0.1%
Butyl paraoxybenzoate 0.05%
The plant extract obtained in Example 6 0.1%
Purified water remaining
Total 100%

<Example 43>
Liquid dentifrice polyoxyethylene hydrogenated castor oil 5%
Ethanol 5%
Xylitol 5%
Sodium citrate 0.15%
Citric acid 0.1%
Saccharin sodium 0.1%
Edetate disodium 0.1%
1-Menthol 0.1%
Paraoxybenzoic acid ester 0.1%
Fragrance 0.1%
Hinokitiol 0.05%
Cetylpyridinium chloride 0.01%
Allantoin 0.01%
5% plant extract obtained in Example 7
Purified water remaining
Total 100%

<Example 44>
Liquid dentifrice ethanol 10%
Polyethylene glycol 2%
Polyoxyethylene hydrogenated castor oil 2%
Sodium benzoate 1%
Fragrance 0.4%
Allantoin 0.2%
Edetate disodium 0.2%
Tea dry distillation solution 0.1%
Stevia extract 0.05%
Hinokitiol 0.02%
Aluminum lactate 0.01%
Cetylpyridinium chloride 0.01%
3% plant extract obtained in Example 8
Purified water remaining
Total 100%

<Example 45>
Liquid dentifrice hydrous silicate 1%
Silica anhydride 10%
Glycerin 25%
Fragrance 1%
Carboxymethyl cellulose 1%
Sorbitol 50%
Polyoxyethylene hydrogenated castor oil 0.5%
Paraoxybenzoic acid ester 0.1%
Sodium lauryl sulfate 1%
3% plant extract obtained in Example 9
Purified water remaining
Total 100%

<Example 46>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 1 0.3%
Purified water remaining
Total 100%

<Example 47>
Mouthwash xylitol 25%
Denatured alcohol No. 56 5%
Glycerin 5%
Polyoxyethylene hydrogenated castor oil 0.5%
Dipotassium glycyrrhizinate 0.1%
Sodium citrate 0.12%
Citric acid 0.03%
Ethyl paraoxybenzoate 0.05%
Propyl paraoxybenzoate 0.05%
Fragrance 0.1%
1% plant extract obtained in Example 2
Purified water remaining
Total 100%

<Example 48>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 3 0.3%
Purified water remaining
Total 100%

<Example 49>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 4 0.3%
Purified water remaining
Total 100%

<Example 50>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 5 0.3%
Purified water remaining
Total 100%

<Example 51>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 6 0.3%
Purified water remaining
Total 100%

<Example 52>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 7 0.3%
Purified water remaining
Total 100%

<Example 53>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 8 0.3%
Purified water remaining
Total 100%

<Example 54>
Mouthwash ethanol 20%
Fragrance 1%
Saccharin sodium 0.05%
Chlorhexidine hydrochloride 0.01%
Laurylethanolamide 0.3%
The plant extract obtained in Example 9 0.3%
Purified water remaining
Total 100%

<Example 55>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 1
Total 100%

<Example 56>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 2
Total 100%

<Example 57>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 3
Total 100%

<Example 58>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 4
Total 100%

<Example 59>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 5
Total 100%

<Example 60>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 6
Total 100%

<Example 61>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 7
Total 100%

<Example 62>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 8
Total 100%

<Example 63>
Chewing gum gum base 20%
15% sugar
Isomaltose 20%
Maltose 20%
Corn syrup 12%
Minamata 11.5%
Fragrance 0.5%
1% plant extract obtained in Example 9
Total 100%

<Example 64>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 1
Water remaining
Total 100%

<Example 65>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 2
Water remaining
Total 100%

<Example 66>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 3
Water remaining
Total 100%

<Example 67>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 4
Water remaining
Total 100%

<Example 68>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 5
Water remaining
Total 100%

<Example 69>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 6
Water remaining
Total 100%

<Example 70>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 7
Water remaining
Total 100%

<Example 71>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract obtained in Example 8
Water remaining
Total 100%

<Example 72>
Lozenge gum arabic 6%
Palatinose 30%
Multitose 20%
Isomaltose 22%
Gelatin 3%
Fragrance 0.2%
1% plant extract from Example 9
Water remaining
Total 100%

Claims (4)

  Parkia speciosa (scientific name: Parkia speciosa), Chromolaena odoratum (scientific name: Anachromus pyrethrum DC.), Ocrocarpus longifolius (scientific name: Ochrocarpus longifolius), Aganosma ), Tectona grandis (scientific name: Tectona grandis), Leitia tomentosa (scientific name: Wrightia tomentosa), Diopiros rhodocalyx (scientific name: Diospyros rhodocalyx Kurz), and Bauer Burmanica Griff (scientific name: Bouer Burmanica Griff). A reactive oxygen scavenger comprising a plant extract as an active ingredient.   A skin external preparation containing the active oxygen scavenger according to claim 1.   An oral composition containing the active oxygen scavenger according to claim 1.   A food containing the active oxygen scavenger according to claim 1.