JPH05294819A - Beautifying cosmetic - Google Patents

Abstract

PURPOSE:To obtain a beautifying cosmetic having excellent beautifying effects, high safety and stability. CONSTITUTION:A beautifying cosmetic comprising an extract of one or more plants selected from Polygonum cuspidatum Sieb. et Zucc., Polygonum cuspidatum Sieb. et Zncc. var. hachidyoense Ohwi and Polygonum sachalinenser Fr. Schm. The plant extract has high inhibitory action on tyrosinase activity, suppresses formation of dopachrome from tyrosine and reduces melanism. The plant extract has excellent safety and stability in cosmetic.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition containing a specific plant extract, which has an excellent whitening effect and is highly safe and stable.

[0002]

2. Description of the Related Art Whitening cosmetics have been of great interest in improving skin darkening, spots, freckles, etc., and ascorbic acid, glutathione, colloidal sulfur, etc. have been effective in them. It has been compounded as an ingredient.

There are also examples in which various medicinal plant extracts, plant-derived gallic acid, geraniin and the like are used. further,
Whitening ingredients such as kojic acid and arbutin, a glucopyranoside derivative, have also been used recently.

[0004]

However, ascorbic acid is liable to be oxidized and is unstable, and glutathione and colloidal sulfur have a drawback that they have a peculiar offensive odor and precipitation.

In addition, the conventional medicinal plant extracts have problems that the effect is not sufficient and the quality is not constant. Furthermore, it was necessary to consider maintaining the stability of kojic acid and the like. Besides,
In some cases, side effects occurred due to continuous use.

The present invention is intended to solve such problems and provide a whitening cosmetic composition which is excellent in whitening effect and which is highly stable and safe.

[0007]

[Means for Solving the Problems] Since cosmetics are continuously used every day, the active ingredient to be added to the cosmetics has a mild action, shows sufficient effects by continuous use, and has no side effect due to continuous use. Is desired. From such a viewpoint, a natural product-derived substance, particularly an extract of a medicinal plant, is preferable, but in order to solve the above-mentioned problems in effectiveness of the action, stability of quality, etc. From among them, those having an effective and mild skin lightening effect and having high stability were screened.

As a result, the Japanese knotweed ( Polygonum cuspidat)
um Sieb. et Zucc.), Yellow-tailed Plover ( Polygonum)
cuspidatum Sieb. et Zucc. var. hachidyoense Ohw
i) and Giant Plover ( Polygonum sachalinense Fr.
In the extract of Schm.), A high tyrosinase activity inhibitory effect was found. These extracts had no adverse effects on the skin such as skin irritation and contact sensitization, and when incorporated into cosmetics, the tyrosinase activity inhibitory action was not inactivated and the quality was stable.

Therefore, the Japanese knotweed ( Polygonum cuspidatum)
Sieb. Et Zucc.), Yellow-tailed Plover ( Polygonum c)
uspidatum Sieb. et Zucc. var. hachidyoense Ohw
i) and Giant Plover ( Polygonum sachalinense Fr.
By combining the extract of one or more plants selected from Schm.), A whitening cosmetic with a mild action and a sufficient whitening effect can be expected, and safety and stability are high. Came to do.

[0010]

The plant extract used in the present invention is generally 10 to 30 parts of dried or shredded fresh plant, an organic solvent such as ethanol or propylene glycol, or a mixture of these organic solvents, or Is obtained by adding 100 parts of a mixture of water and the above organic solvent, conducting extraction with stirring at room temperature for about 1 week, and then filtering to collect a filtrate. The whitening effect of these plant extracts was evaluated by the inhibition rate of tyrosinase activity. The evaluation was performed as follows.

First, 10 g of dried plant pieces were put in 100 ml of 50% by weight ethanol and extracted at room temperature for 1 week. This plant extract was diluted 100-fold with purified water to prepare a sample solution. Next, tyrosinase (50,000
units, manufactured by Sigma) were diluted 600 times with purified water to obtain an enzyme solution. The substrate solution was prepared by dissolving 50 mg of tyrosine in 100 ml of purified water.

The enzyme reaction was carried out using a sample solution of 2 ml, 1 / 15M.
Phosphate buffer (pH 6.8) 2 ml, substrate solution 0.5 m
1 and 0.5 ml of the enzyme solution were mixed and incubated at 37 ° C. for 1 hour. After the reaction, the absorbance (As) at 475 nm was measured. Further, the same reaction was carried out in a system in which purified water was added instead of the sample solution and a system in which purified water was added instead of the substrate solution, and the absorbance (Ab and A0) in each case was measured. The tyrosinase activity inhibition rate was calculated by the equation 1.

[Equation 1]

The measurement results are shown in Table 1. As is clear from Table 1, each of the plant extracts used in the present invention exhibits a significantly high tyrosinase activity inhibition rate, reduces the production of dopachrome from tyrosine, and exerts an effective whitening effect. there were.

[Table 1]

In the present invention, the blending amount of the above plant extract in the whitening cosmetic is appropriately 0.001 to 20% by weight. If the blending amount is 0.001% by weight or less, a sufficient whitening effect cannot be obtained, but since the whitening effect is quite strong, it is not necessary to blend it in a too large amount. Can also affect.

Further, the whitening cosmetic composition according to the present invention is a softening lotion, astringent lotion, lotion such as cleansing lotion, emollient cream, moisturizing cream, massage cream, cleansing cream, makeup cream, etc. Creams, emollient emulsions, moisturizing emulsions, nourishing emulsions, cleansing emulsions and other emulsions,
Various formulation forms such as packs such as jelly-like packs, peel-off packs and powder-like packs, and face wash can be used.

Furthermore, other active ingredients such as moisturizers, anti-inflammatory agents, and ultraviolet absorbers can be used in combination, and sunscreen cosmetics, skin protective cosmetics, rough skin improving cosmetics and other medicated cosmetics or It can also be provided as a quasi drug.

[0017]

EXAMPLES Next, the present invention will be described in more detail by way of examples.

Example 1 is a whitening cream according to the present invention. The prescription is shown in Table 2. In Table 2, (1) to (7) were heated and dissolved at 75 ° C, (10) to (13) heated and dissolved at 75 ° C were added to emulsify, and the mixture was cooled at 50 ° C (8). , (9) are added and further cooled to obtain a whitening cream.

[Table 2]

Example 2 is a whitening emulsion according to the present invention.
The prescription is shown in Table 3. In Table 3, (1) to (8) were heated and dissolved at 75 ° C, (11) to (15) heated and dissolved at 75 ° C were added to emulsify, and the mixture was cooled at 50 ° C (9). )-(10) are added and further cooled to obtain a whitening emulsion.

[Table 3]

Comparative Example 1 was the same as Example 1 except that the knotweed extract (9) was removed and the total amount was 100% by weight with purified water. Similarly, Comparative Example 2 was prepared by removing the Japanese knotweed extract of (10) in Example 2 and adjusting the total amount to 100% by weight with purified water.

Using the above examples and comparative examples, use tests were conducted to evaluate the whitening effect. In the use test, 40 female panelists aged 30 to 40 years old who are worried about stains and freckles are randomly divided into 4 groups of 10 persons, and Examples 1 and 2 and Comparative Examples 1 and 2 are blinded in each group. I went to use it.
After washing the face twice daily in the morning and at night, an appropriate amount of the sample was applied to the face and the use was continued for 2 months. The whitening effect was evaluated by observing the condition of facial spots and freckles after the use test. The results are shown in Table 4.

[Table 4]

In Table 4, in the group using Example 1, improvement in spots and freckles was observed in 9 subjects, and the remaining 1
The name also showed some improvement. The effective rate for improving spots and freckles was 100%. Also in the use group of Example 2, improvement in spots and freckles was observed in 8 subjects, and slight improvement in the remaining 2 subjects, and the efficacy rate in improving spots and freckles was similarly 100%. On the other hand, in the group using Comparative Example 1, none of the panelists recognized an improvement in spots and freckles. In the group using Comparative Example 2, a small amount of the ascorbic acid derivative was used, so that a slight improvement was observed in one subject, but no improvement was observed in the remaining nine subjects.

Further, no panelists complained of skin irritation such as pain or itch or skin disorder such as allergic reaction in any of the groups used in the above-mentioned use test period. Further, no deterioration of the quality of the cosmetic such as sedimentation and deterioration of the blended components was observed.

[0024]

As described above, according to the present invention, it is possible to provide a whitening cosmetic composition which exhibits an effective whitening effect and is excellent in stability and safety.

Claims (1)

[Claims] 1. A knotweed ( Polygonum cuspidatum Sieb.
et Zucc.), Hummingbird ( Polygonum cuspida)
tum Sieb. et Zucc. var. hachidyoense Ohwi), and Ooitadori (Polygonum sachalinense Fr. Schm. 1 Tanemata selected from) is characterized by blending an extract of two or more plants, whitening cosmetics.