JP3119622B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a tyrosinase activity inhibitor, and more particularly to a tyrosinase activity inhibitor containing, as an active ingredient, an extract consisting of a gardenia fruit, a jinjin root, an Eijitsu fruit or a fraction thereof. . The tyrosinase inhibitor of the present invention is used for improving skin tone and the like.

[0002]

2. Description of the Related Art Tyrosine, a kind of amino acid, produces a black-brown or red-brown pigment or melanin by the action of tyrosinase, and may cause spots or freckles on the skin. Therefore, in order to prevent the production of melanin due to the action of tyrosinase, various substances capable of inhibiting the action of tyrosinase have been conventionally used or proposed in the field of cosmetics and foods.

[0003] The typical ones are ascorbic acid, sulfurs, hydroquinone, kojic acid and natural plant extracts.

However, ascorbic acid has a problem in terms of stability when water is present, and sulfur has a problem in terms of odor. Hydroquinone has the drawback of being highly effective but highly toxic. Kojic acid and natural plant extracts have high safety but weak tyrosinase inhibitory activity, and many plant extracts have problems in terms of smell, color and the like.

[0005]

In recent years, as public interest in the safety of cosmetics having a great influence on health maintenance has increased, tyrosinase activity inhibitors used for preventing melanin production have also become highly safe natural products. There has been a strong demand for a system-based material that does not adversely affect the quality of the object to be added in terms of taste or smell and that can be widely used in cosmetics.

An object of the present invention is to provide a cosmetic composition characterized by containing three kinds of extracts of gardenia, kujin and Eijitsu which have a tyrosinase activity-inhibiting action which can meet such a demand.

[0007]

According to the present invention, in order to achieve this object, gardenia fruits, lotus roots, and oak fruits are treated with water, a hydrophilic organic solvent or a mixture thereof.
It is characterized by containing three kinds of extracts obtained by extraction processing.
It is intended to provide cosmetics .

[0008] In this case, it is preferable that the ratio of the compounding ratio of the gardenia extract, the jinjin extract, and the oak extract is in the range of 1: 1: 2 to 4.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Gardenia (Gardenia j)
(Aminoides) is a plant of the family Rubiaceae, the fruit of which has been used as a Chinese herbal prescription drug for purposes such as antipyretic, anti-inflammatory and hemostatic.

[0010] Kujin (Sophora flavesc)
ens) is a leguminous plant, the roots of which have been used as diuretic and astringent lagoon medicines. In cosmetics, it has been used as an antibacterial agent.

Ages (Rosa multifor)
a) Dried mature fruit of Roeaceae, Noibara, which has been used as a diuretic under lagoons. In cosmetics, it has been used as an antibacterial agent.

[0012] Gardenia fruits, jinjin roots and age fruits are appropriately ground and then subjected to extraction using water, a hydrophilic organic solvent or a mixture thereof as a solvent. As the organic solvent for extraction, lower alcohols such as methanol and ethanol, and polyhydric alcohols such as 1,3-butylene glycol are most suitable. The extraction method is not particularly limited, but the active ingredient can be easily extracted by immersion in a solvent maintained at room temperature or a temperature near the boiling point.

The tyrosinase activity inhibitor according to the present invention comprises:
Gardenia extract 15-30%, Kujin extract 15-3
When mixed at a ratio of 0% and Age extract 40 to 70% , the effect is higher than when each is mixed alone.

When the tyrosinase-inhibiting activator according to the present invention is used in cosmetics, astringents, bactericidal / antibacterial agents, whitening agents, UV absorbers, humectants, It can be used as a more general cosmetic if it is appropriately combined with physiologically active substances and other active substances that can be used as cosmetic constituents, such as cell activators, anti-inflammatory / antiallergic agents, antioxidants / active oxygen scavengers, etc. It is possible to do. In such a case, a synergistic effect with another active ingredient used in combination may bring about an excellent use effect that is higher than the effect normally expected.

Specific examples of cosmetic components which can be used in combination with the tyrosinase activity inhibitor according to the present invention are as follows.

Astringents: citric acid or a salt thereof, tartaric acid or a salt thereof, aluminum chloride, aluminum sulfate, potassium sulfate, ju extract, hamamelis extract, gennoshoco extract, sycamore extract, salvia extract, maronier extract, horsetail extract, melissa extract and the like.

Bactericidal and antibacterial agents: benzoic acid, sodium benzoate, benzethonium chloride, salicylic acid, sodium salicylate, sorbic acid, resorcin, bisabolol, hinokitiol, menthol, chitosan, enmeiso extract, loquat extract, yucca extract, aloe extract and the like.

Whitening agent: ascorbic acid and its derivatives, sulfur, kojic acid and its derivatives, glucosamine and its derivatives, glutathione, arnica extract, gongon extract, soybean extract, psycho extract, yoquinin extract, malonier extract, oil-soluble licorice extract ( Licorice hydrophobic flavone, glabridine, grabrene, lycochalcone A) and the like.

UV absorbers: β-isopropylfuranone derivative, urocanic acid, oxybenzone, paraaminobenzoic acid, octyl methoxycinnamate, titanium oxide, β-
Carotene, γ-oryzanol, aloe extract, rice bran extract, chamomile extract, hawthorn and the like.

Humectants: serine, glycine, alanine, collagen, hydrolyzed collagen, keratin, elastin, royal jelly, chondroitin heopaline, pectin, bifidous acid fermentation, lactic acid fermentation, yeast extract,
Jojoba oil, yokuinin extract, Jiaogu extract, daisy extract, Kidachi aloe extract, burdock extract and the like.

Cell activator: Riboflapine or its derivative, pyridoxine or its derivative, nicotinic acid or its derivative, pantothenic acid or its derivative, α-tocopherol or its derivative, carrot extract, eleuthero extract, loofah extract, sicon extract, birch extract, Peony extract, sapling extract, safflower extract, garlic extract, etc.

Anti-inflammatory and anti-allergic agents: azulene, allantoin, aminocaproic acid, indomethacin, lysozyme chloride, glycyrrhizic acid or its derivatives, glycyrrhetinic acid or its derivatives, tranexamic acid or its derivatives, perilla extract, spinach extract, Achillea millefolium extract, body extract , Chinko extract, gentian extract and the like.

Antioxidant / active oxygen scavenger: dibutylhydroxytoluene, propyl gallate, baicalin, baicalein, superoxide dismutase, catalase, rosemary extract, loquat leaf extract, sage extract, eucalyptus extract, royal extract, turmeric extract, nutmeg Extract, thyme extract, hop extract, etc.

[0024] Cosmetics having a whitening effect are prepared by using common raw materials used in the manufacture of cosmetics such as oils, surfactants, humectants, preservatives, fragrances, water, alcohols, thickeners, coloring agents, and the like in a conventional manner. Emulsion, lotion, cream, jelly, on manufacturing various cosmetics such as packs, gardenia according to the present invention at any stage of the manufacturing process , kujin,
It can be produced by adding three kinds of Agetsu extract .

[0025] Gardenia, Kujin, Agetsu according to the present invention
Other ingredients for cosmetics production by combining the three extracts
There is almost no restriction on the choice of
Common cosmetic materials and auxiliaries such as
is there.

Oils and fats: soybean oil, linseed oil, drill oil, sesame oil, safflower oil, corn oil, almond oil, coconut oil, castor oil, rapeseed oil, olive oil and the like.

Waxes: Carlauba wax, beeswax, whale wax, Celax, lanolins and the like.

Hydrocarbons: liquid paraffin, vaseline,
Cecilene, squalane, etc.

Fatty acids: stearic acid, linoleic acid, oleic acid, lanolinic acid, myristic acid, balmitic acid,
Hebeninic acid, undecylenic acid and the like.

Alcohols: lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, glycerin, propyl alcohol, 1,3-butylene glycol, ethylene glycol, cholesterol, phytosterol and the like.

Esters: decyl oleate, butyl stearate, myristyl myristate, propylene glycol monostearate, lanolin acetate, glycerin trimyristate, propylene glycol dioleate and the like.

Surfactants: anionic surfactants, cationic surfactants, amphoteric surfactants and the like.

Fragrance: menthol, carvone, eugenol, anethole, peppermint oil, spearmint oil, peppermint oil, eucalyptus oil, anise oil and the like.

[0034]

The present invention will be described below with reference to examples. Incidentally, IC ₅₀ was used to indicate the tyrosinase inhibitory activity shown in Example 1, the smaller the value tyrosinase inhibitory activity shows stronger.

[0035]

Example 1 (Method for measuring tyrosinase inhibitory activity) A 0.05% tyrosine solution containing a tyrosinase activity inhibitor was added.
5 ml, tyrosinase solution (60 μg / ml) 0.7 m
l and 1/15 M phosphate buffer (pH 6.8) 1.8
475n, and mix well at 37 ° C for 1 hour.
The light intensity A at m is measured. The absorbance A is proportional to the concentration of a group of coloring components such as melanin generated from tyrosine. The same procedure is applied to the case where no tyrosinase activity inhibitor is added, absorbance B at 475 nm is measured, and the tyrosinase activity inhibition rate is calculated from the following equation. Inhibition rate (%) = (1−A / B) × 100 The sample concentration was changed stepwise, the above inhibition rate was measured, and the sample concentration at which the inhibition rate was 50% was determined by interpolation, and the IC ₅₀ was determined. And

Sample IC ₅₀ (μg / ml) Gardenia water extract 310 Gardenia ethanol extract 400 Gardenia water / ethanol (1: 1) extract 330 Kuddin water extract 415 Kuddin ethanol extract 320 Kuddin water / ethanol (1: 1) Extract 350 Age Water Extract 115 Age Ethanol Extract 95 Age Water / Ethanol (1: 1) Extract 100 Gardenia, Kujin, Age (1: 1: 1) 155 Gardenia, Kujin, Age (1: 1: 2) 85 Gardenia, Kujin, Ages (1: 1: 4) 75 Gardenia, Kujin, Ages (1: 1: 5) 135

[0037]

Example 2 The following ingredients were homogenized by a conventional method of cream production to produce a neutral cream having a whitening effect. Stearic acid 2 parts Stearyl alcohol 7 parts Reduced lanolin 2 parts Squalane 5 parts Octidedecanol 6 parts Polyoxyethylene cetyl ether 3 parts Glycerin monostearate 2 parts Fragrances 0.1 parts Preservatives / antioxidants 0.1 parts Propylene glycol 5 parts Gardenia extract 1.5 parts Kujin extract 1.5 parts Agetsu extract 4 parts Make up to 100 parts with purified water

[0038]

Example 3 The following ingredients were emulsified by a conventional method for producing an emulsion to produce an emulsion having a whitening effect. Stearic acid 2 parts Cetanol 1.5 parts Vaseline 3 parts Lanolin alcohol 2 parts Liquid paraffin 10 parts Polyoxyethylene monooleate 2 parts Fragrance 0.1 parts Preservatives / antioxidants 0.1 parts Glycerin 3 parts Propylene glycol 5 Part Triethanolamine 1 part Gardenia extract 2 parts Kujin extract 2 parts Age extract 5 parts Make up to 100 parts with purified water

[0039]

Industrial Applicability According to the present invention, tyrosinase which is a natural product having high safety, does not adversely affect the quality of an object to be added in terms of taste and smell, and can be widely used in cosmetics An activity inhibitor can be provided.

──────────────────────────────────────────────────続 き Continuation of front page (56) References JP-A-50-135236 (JP, A) JP-A-60-104005 (JP, A) JP-A-64-26507 (JP, A) JP-A-3- 193712 (JP, A) JP-A-6-65045 (JP, A) JP-A-6-128143 (JP, A) JP-A-6-336418 (JP, A) JP-A-8-99859 (JP, A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 A61K 35/78

Claims (1)

(57) [Claims] 1. A cosmetic containing three extracts, gardenia, gin, and oak, wherein the ratio of the gardenia extract, the oak extract, and the oat extract is 1: 1: 2-4. Cosmetics characterized by that.