JPH11209223A - Humectant and preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a humectant having high safety and excellent humectant effect by making the humectant include an extract from a plant belonging to Juliania family. SOLUTION: This humectant contains, in the case of a preparation for external use for skin, 0.001-20 wt.% preferably 0.01-15 wt.% particularly preferably 0.1-10 wt.% extract from a plant belonging to Juliania family (Cuachelalate or the like) based on the total amount of the composition. The above-mentioned extract from a plant belonging to juliania family is obtained by the steps in which whole grass of a plant belonging to Juliania family such as roots, trunks, branches, leaves, stems including subterranean stems, flowers, fruits is soaked in an extractant (a polar solvent such as water or a lower alcohol or an organic solvent such as chloroform) or refluxingly heated and filtrated thereafter and concentrated.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a novel humectant and an external preparation for skin containing the same. More specifically, the present invention relates to a humectant containing an extract of a plant belonging to the family of the family Iuliaceae, which is highly safe and has an excellent moisturizing effect, and a skin external preparation containing the same and having an excellent moisturizing effect.

[0002]

2. Description of the Related Art Conventionally, skin external preparations have been used for various purposes such as improvement of usability and safety, reduction of skin irritation, and preservation, for example, polyethylene glycol, propylene glycol, and the like.
Glycerin, 1,3-butylene glycol, xylitol,
Sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO ) Moisturizers such as PO adducts, Izayobara extract, Achillea millefolium extract, and melilot extract are incorporated.

[0003]

However, many of these moisturizers have poor functions and the expected effects are not always sufficient, and depending on the type of the compound, the oxidative stability, odor, etc. However, there is a problem in using it for an external preparation for skin.

[0004] In view of such circumstances, the present inventors have conducted intensive studies to obtain a skin external preparation having a truly excellent moisturizing effect, and as a result, have not been used as a raw material for cosmetics. Has been found to have an excellent moisturizing effect, and it has been found that when it is added to an external preparation for the skin, a skin external preparation having an excellent moisturizing effect can be obtained, thereby completing the present invention.

An object of the present invention is to provide a novel moisturizing agent and a skin external preparation containing the same and having an excellent moisturizing effect.

[0006]

That is, the present invention provides a humectant characterized by containing an extract of a plant belonging to the family Iuriaceae as an active ingredient.

[0007] The present invention also provides the above-mentioned moisturizing agent, wherein the plant of the family Yulianiaceae is Cuachalalate.

Further, the present invention provides an external preparation for skin characterized by containing an extract of a plant belonging to the family Iuriaceae.

[0009] The present invention also provides the above external preparation for skin, wherein the plant of the family Yulianiaceae is Cuachalalate.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The extract of the plant of the family Iulianiaceae used in the present invention is characterized by being excellent in safety and having low skin irritation. Therefore, it is a compound that can be used as an excellent moisturizing agent in skin external preparations.Conventionally, an extract of a plant belonging to the family Iuriaceae has never been blended as a moisturizing agent for cosmetics and the like. It is a new raw material.

[0012] As the Yulianiaceous plant used in the present invention, Cuachalalate (scientific name: Juliania)
adstringens) are preferred. Quacharate is already known to be effective for wound healing, hair loss, etc. (Japanese Patent Laid-Open No. 181313/1992), but there is no report on the moisturizing effect of the skin, and it was first discovered by the present inventors. This is a new effect. Quacharate
It is a plant that grows especially in the Acapulco region on the southern Pacific coast of Mexico.

[0013] The extract used in the present invention is obtained by immersing or heating and refluxing the whole plant such as roots, stems, branches, leaves, stems including rhizomes, flowers, fruits, etc. of an uriania plant together with an extraction solvent, followed by filtration. It is obtained by concentration. The extraction solvent is not particularly limited as long as it is a solvent usually used for extraction.
Use a polar solvent such as water, lower alcohol, hydrated lower alcohol, propylene glycol, 1,3-butylene glycol, butanol or an organic solvent such as chloroform, dichloroethane, carbon tetrachloride, acetone, ethyl acetate, ether or the like alone or in combination. be able to.

The amount of the extract of the plant belonging to the family Iuriaceae in the present invention is not particularly limited, but is generally 0.001 to 20% by weight, preferably 0.01 to 20% by weight, based on the total amount of the external preparation for skin as a dry matter weight. 15% by weight, particularly preferably 0.1 to 10% by weight. 0.001
If the amount is less than 20% by weight, the moisturizing effect of the external preparation tends to be poor. Conversely, if the amount exceeds 20% by weight, the effect cannot be substantially increased, and the compounding into the external preparation tends to be difficult. is there.

The external preparation for skin of the present invention includes, in addition to the above essential components, other components usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as oils, wetting agents, ultraviolet absorbers, antioxidants, Surfactants, preservatives, other humectants, fragrances, colorants, water, alcohols, thickeners, polymers, powders, drugs, chelating agents, plant extracts, etc. can be appropriately compounded as necessary. .

The dosage form of the external preparation for skin of the present invention is arbitrary,
The essential components of the present invention depending on the target product, such as a solution system, a solubilizing system, an emulsifying system, an oil-liquid system, a gel system, a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, etc. And the above-mentioned optional components can be blended to produce the compound by a conventional method.

The external preparation for skin of the present invention refers to those applied to the outer skin (including the scalp) as cosmetics, pharmaceuticals, and quasi-drugs, and includes, for example, facials such as lotions, emulsions, creams, and packs. Cosmetics, foundation, lipstick,
It can be used for makeup cosmetics such as eye shadows, body cosmetics, aromatic cosmetics, scalp hair cosmetics, cleaning agents, ointments and the like.

[0018]

Next, the present invention will be described in more detail by way of examples. The present invention is not limited by this. All amounts are by weight.

Example 1 The moisturizing effect of the humectant of the present invention was evaluated by the following test method.

<Preparation of sample: Cuachalalate extract of a plant of the family Iuriaceae> 100 g of the stem of Cuachalalate was immersed in ethanol at room temperature for 1 week, and the extract was concentrated. 2 g were obtained.

<Measurement of Moisturizing Effect by Moisture Evaporation Rate> As a test for measuring the moisturizing effect of the humectant, the samples shown in Table 1 were measured for the moisture evaporation rate. That is,
After dropping 10 μl of the test solution onto a 2.0 × 2.0 cm filter paper,
Every minute, the weight loss was measured for 10 minutes, and the weight loss per minute was determined. The humectant was prepared by dissolving the ethanol extract and the humectant of Comparative Example in water and adjusting the concentration to 1% by weight as a sample solution. The moisturizing effect was evaluated according to the following criteria, and the results are also shown in Table 1. As is clear from Table 1, it was confirmed that the example of the moisturizing agent of the present invention had a better moisturizing effect than the comparative example of the conventional moisturizing agent.

(Evaluation criteria) A: Water evaporation rate 0.50 μg / min. Less than ○: Water evaporation rate 0.50 to 0.55 μg / min. Δ: Water evaporation rate 0.55 to 0.60 μg / min. ×: Water evaporation rate 0.60 μg / min. that's all

[0023]

[Table 1] ---------------------------------------------- ----------------- Moisturizer Moisturizing effect ----------------------------- ---------------------------------- Example 1: Cuachalalate extract ◎ ----- -------------------------------------------------- -------- Comparative Example 1: No humectant (purified water) × ------------------------------ --------------------------------- Comparative Example 2: Glycerin ○ ----------- -------------------------------------------------- -Comparative Example 3: Porpyrene glycol △ ---------------------------------------- -----------------------

<Skin Moisturizing Effect Test> The moisturizing effect on the skin was evaluated using panels of 20 men and women. The evaluation method was as follows: after washing the upper arm, a sample solution prepared by dissolving the ethanol extract and the humectant of the comparative example in water and adjusting to 1% by weight was applied, and the TWL and skin conductance before the test were as described below. The change in value was measured to test the moisturizing effect of the skin. Evaluation was performed according to the following evaluation criteria, and the results are shown in "Table 2". As is clear from Table 2, it was recognized that the skin moisturizer of the present invention, which is a moisturizer of the present invention, has a more excellent skin moisturizing effect than the conventional moisturizer of the comparative example.

Conductance change rate = Conductance change amount / Conductance value TWL change rate before use = TW
L change amount / TWL value before use (Evaluation criteria) ：: Conductance change rate + 10% or more △: Conductance change rate + 3% or more and less than + 10% ×: Conductance change rate + 3% or less Ｔ: TWL change rate + 10% or more △: TWL change rate + 3% or more and less than + 10% ×: TWL change rate + 3% or less

[0026]

[Table 2] ---------------------------------------------- ----------------- Moisturizer Moisturizing effect Contactance TWL --------------------------- ------------------------------------ Example 1: Cuachalalate extract ○ ○- -------------------------------------------------- ----------- Comparative Example 1: No humectant (purified water) × × -------------------------- ------------------------------------- Comparative Example 2: Glycerin ○ ○ ------ -------------------------------------------------- ------- Comparative Example 3: Porpyrene glycol △ △ ---------------------------------- -----------------------------

Examples of the external preparation for skin using the moisturizing agent of the present invention are shown below.

"Example 2: lotion" The following lotions were produced by a conventional method. Propylene glycol 5.0% citric acid 4.0 Quacharate ethanol extract 3.0 95% ethanol 8.0 POE (20) lauryl ether 2.0 Preservative / antioxidant Appropriate amount Perfume Appropriate amount Ion-exchanged water residue Extra

Example 3: Vanishing cream Stearic acid 5.0 Stearic alcohol 4.0 Stearic acid butyl alcohol ester 8.0 Glycerin monostearate 2.0 Ascorbic acid distearate 1.0 Propylene glycol 10.0 Quachara Latte ethanol extract 1.0 Preservative / Antioxidant qs Perfume qs Ion-exchanged water residue (Preparation method) Add quacharate ethanol extract and propylene glycol to ion-exchanged water, dissolve and heat.
Keep at 0 ° C. (aqueous phase). Mix other ingredients, heat and melt.
Keep at 0 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 4: Vanishing cream Stearic acid 6.0 Sorbitan monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monostearate 1.5 Arbutin 7.0 Propylene glycol 10.0 k Acalarate ethanol extract 5.0 Preservatives / antioxidants Appropriate amount Fragrance Appropriate amount Ion exchange water residue (Preparation method) Add quatararate ethanol extract, arbutin and propylene glycol to ion exchange water and heat to 70 ° C Keep (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, and after uniform emulsification with a homomixer, the mixture is cooled to 30 ° C. while stirring well.

Example 5 Neutral Cream Stearyl Alcohol 7.0 Stearic Acid 2.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodeserial Cole 6.0 Polyoxyethylene (25 Mol) Cetyl Alcohol ether 3.0 Glycerin monostearate 2.0 Placenta extract 0.1 Propylene glycol 5.0 Quacharate ethanol extract 10.0 Perfume Appropriate amount Preservative / antioxidant Appropriate amount Ion exchange water residue ( Production method) Quacharate ethanol extract, placenta extract and propylene glycol are added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, and after uniform emulsification with a homomixer, the mixture is cooled to 30 ° C. while stirring well.

Example 6 Cold Cream Solid Paraffin 5.0 Beeswax 10.0 Vaseline 15.0 Liquid Paraffin 41.0 Glycerin Monostearate 2.0 Polyoxyethylene (20 mol) 2.0 Sorbitan Monolaurate ester Kojic acid 2.0 Soap powder 0.1 Borax 0.2 Quacharate ethanol extract 0.1 Ion-exchanged water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount (Production method) The ethanol extract of acharate, kojic acid, soap powder and borax are added, dissolved by heating and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After the completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

"Example 7: Emulsion" Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (Shin-Etsu Chemical) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Arbutin 2.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Quacharate ethanol extract 20 0.0 ion-exchanged water residue (Preparation method) Quacharate ethanol extract and arbutin were heated and dissolved in ion-exchanged water and ethanol, and a water-soluble component of propylene glycol or less was dissolved.
Keep at ° C (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, preliminarily emulsified, homogenized with a homomixer, emulsified, and cooled to 30 ° C. while stirring well.

Example 8: Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 3.0 Propylene glycol 5.0 Sodium ascorbic acid-2-sulfate 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropyl cellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Suitable Amount Quacharate ethanol extract 7.0 Ion-exchanged water Residue (Production method) Heat-dissolve ion-exchanged water and quacharate ethanol extract, and further dissolve water-soluble components of propylene glycol or less, and add 70 ° C. (Aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase).
The oil phase is added to the water phase, preliminarily emulsified, and uniformly emulsified by a homomixer. After emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 9: Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 3.0 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Placental extract 5.0 Quacharate Ethanol extract 7.0 Ion-exchange water Residue (Preparation method) Quacharate ethanol extract and placenta extract are heated and dissolved in ion-exchange water and ethanol, and water-soluble components such as propylene glycol or less are dissolved.
Keep at 0 ° C. (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, preliminarily emulsified, and uniformly emulsified by a homomixer. After emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 10: Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (Shin-Etsu Chemical) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Glucerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Kojic acid 3.0 Quacharate ethanol extract 3.0 Ion-exchanged water Residue (Preparation method) Quacharate ethanol extract and kojic acid are dissolved in ion-exchanged water and ethanol by heating, and water-soluble components such as propylene glycol or less are dissolved.
Keep at ° C (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, preliminarily emulsified, and uniformly emulsified by a homomixer. After emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 11: Emulsion 1.5 stearic acid 1.5 cetyl alcohol 0.5 beeswax 2.0 polyoxyethylene (20 mol) monooleate 1.0 glycerin monostearate 1.0 quince seed Extract (5% aqueous solution) 20.0 Ethyl alcohol 10.0 Arbutin 20.0 Propylene glycol 5.0 Quacharate ethanol extract 3.0 Ion-exchange water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount ( Production method) Quacharate ethanol extract, arbutin and propylene glycol are added to ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). Add flavor to ethyl alcohol and dissolve (alcohol phase). Other components except the quince seed extract are mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, and homogenized uniformly with a homomixer. While stirring, add the alcohol phase and the quince seed extract. Then, cool to 30 ° C with stirring.

Example 12: Emulsion Microcrystalline wax 1.0 Beeswax 2.0 Lanolin 2.0 Liquid paraffin 20.0 Squalane 10.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) 1.0 Sorbitan monooleate arbutin 5.0 Kojic acid 5,0 Propylene glycol 7.0 Quacharate ethanol extract 2.0 Ion-exchanged water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount (production method) A quacharate ethanol extract, arbutin, kojic acid, and propylene glycol are added to ion-exchanged water, and the mixture is heated and maintained at 70 ° C (aqueous phase). The other components are mixed, dissolved by heating and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to the oil phase, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 13: Jelly 95% ethyl alcohol 10.0 dipropylene glycol 15.0 polyoxyethylene (15 mol) oleyl alcohol ether 2.0 arbutin 0.5 ascorbic acid distearate 0.5 carboxyvinyl Polymer (trade name: Carbopol 941) 1.0 Caustic potash 0.15 L-arginine 0.1 Quacharate ethanol extract 2.0 Perfume Appropriate amount Preservative Appropriate amount Ion-exchange water Residue (Preparation method) To ion-exchange water Quacharate ethanol extract, arbutin and carbopol 941 are uniformly dissolved, while dipropylene glycol in 95% ethanol,
Polyoxyethylene (15 mol) oleyl alcohol ether and other components are dissolved and added to the aqueous phase. Then, it is neutralized with caustic potash and L-arginine to increase the viscosity.

“Example 14: Peel-off type pack” (alcohol phase) 95% ethanol 10.0 polyoxyethylene (15 mol) oleyl alcohol ether 2.0 preservative appropriate amount perfume appropriate amount (aqueous phase) Ethanol extract 4.0 Arbutin 1.0 Polyvinyl alcohol 12.0 Glycerin 3.0 Polyethylene glycol 1500 1.0 Ion-exchange water Residue (Preparation method) Prepare an aqueous phase at 80 ° C and cool to 50 ° C.
Then, the alcohol phase prepared at room temperature is added, mixed uniformly, and left to cool.

Example 15: Pack with Powder (Alcohol Phase) 95% Ethanol 2.0 Preservatives Appropriate Perfume Appropriate Coloring Appropriate Appropriate Ascorbate Dioleate 1.0 (Aqueous Phase) Quacharate Ethanol Extract 7.0 Arbutin 1.0 Propylene glycol 7.0 Zinc flower 25.0 Kaolin 20.0 Ion-exchanged water Residue (Preparation method) A water phase is uniformly prepared at room temperature. Then, the alcohol phase prepared at room temperature is added and mixed uniformly.

Example 16: Water Absorbing Ointment Vaseline 40.0 Stearyl Alcohol 18.0 Mokurou 20.0 Polyoxyethylene (10 mol) Monooleate 0.25 Quacharate Ethanol Extract 0.25 Placenta Extract 1.0 Baringglycerin ester / hydrochloride 10.0 Ion exchange water residue (Preparation method) Quacharate ethanol extract and placenta extract are added to ion exchange water and kept at 70 ° C (aqueous phase). Other components are mixed and dissolved at 70 ° C. (oil phase). The oil phase is added to the aqueous phase, and the mixture is uniformly emulsified with a homomixer and then cooled.

The skin external preparations obtained in the present invention all showed excellent moisturizing effects in the moisturizing effect performed in Example 1.

[0044]

According to the present invention, a novel humectant having an excellent moisturizing effect can be provided. In addition, it is possible to provide a skin external preparation that is highly safe, has an excellent moisturizing effect, and is excellent in usability.

Claims (4)

[Claims] 1. A humectant comprising an extract of a plant of the family Julianiaceae as an active ingredient. 2. The method according to claim 1, wherein the Julianian plant is Cuachalalate.
A humectant as described. 3. An external preparation for skin, characterized by containing an extract of a plant of the family Julianiaceae. 4. The method according to claim 3, wherein the plant of the family Julianiaceae is Cuachalalate.
The topical skin preparation according to the above.