JPH06271452A - Skin cosmetic containing extract of plant of cactuses - Google Patents

Skin cosmetic containing extract of plant of cactuses

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Publication number
JPH06271452A
JPH06271452A JP8401493A JP8401493A JPH06271452A JP H06271452 A JPH06271452 A JP H06271452A JP 8401493 A JP8401493 A JP 8401493A JP 8401493 A JP8401493 A JP 8401493A JP H06271452 A JPH06271452 A JP H06271452A
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hair
extract
cosmetic
action
skin
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JP8401493A
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JP3484638B2 (en )
Inventor
Junichi Akiyama
Takeshi Sunakawa
武 砂川
純一 秋山
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Kaminomoto Honpo:Kk
株式会社加美乃素本舗
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Abstract

PURPOSE: To obtain a skin cosmetic comprising an extract from a plant of cactuses as an active ingredient.
CONSTITUTION: A skin cosmetic comprises an extract from a plant of cactuses having antioxidant action and/or inhibitory action on formation of lipoperoxide and optionally a well-known component having inhibitory action on formation of lipoperoxide as active ingredients. Since the extract has excellently preventing and improving action on change in skin by aging or exposure to sunlight and is an extract from a naturally-occurring material. Cosmetics such as creams, toilet lotions and milky lotions, cosmetic for hair such as hair creams, hair lotions, shampoos, rinses, hair tonics and hair nourishing agents, bathing agents, etc., having excellent safety are obtained.
COPYRIGHT: (C)1994,JPO&Japio

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は、皮膚外用剤組成物、更に詳しくは皮膚の加齢あるいは日光暴露等による変化を予防、改善する作用に優れ、また、安全性の高い皮膚化粧料に関するものである。 BACKGROUND OF THE INVENTION This invention is a skin external composition, more specifically preventing the changes caused by aging or sun exposure such skin, excellent effect of improving also relates highly safe skin cosmetic it is.

【0002】 [0002]

【従来の技術】皮膚化粧料組成物には種々の研究がこれまでなされており、種々の薬効成分が配合されている。 Of the Related Art skin cosmetic compositions have been made various studies have heretofore, various medicinal components are blended.
皮膚の加齢や日光暴露等による変化は美容的に問題となることから、その変化の予防や改善に優れた効能をもつ化粧料や皮膚外用剤組成物が求められてきた。 Change due to aging or sun exposure such as the skin from becoming a problem cosmetic, cosmetics and skin external preparation composition having excellent efficacy in prevention and amelioration of change have been sought. こうした中で、これまで、各種の原料、例えばビタミン類、糖類、脂質類等がその使用効果が特徴的であるため皮膚化粧料に配合されてきた。 Among these, heretofore, various ingredients, such as vitamins, sugars, lipids and the like that use effects have been incorporated into skin cosmetics because of its characteristic.

【0003】 [0003]

【発明が解決しようとする課題】しかしながら、その効果はいまだ十分でなく、より優れた効能をもち、且つ、 [SUMMARY OF THE INVENTION However, the effect is not yet sufficient, have better efficacy, and,
安全性の高い配合成分の開発が求められている。 It has been required to develop a high ingredients safety. 本発明においては、皮膚の機能的低下をもたらす原因とされる、過酸化反応に関与するフリーラジカルの除去作用をもつ、スーパーオキサイドディスムターゼ(SOD)様活性を有する成分の研究に基づいて、優れた抗酸化作用あるいはフリーラジカル除去作用を有する薬剤の開発を行ったものである。 In the present invention, is a cause leading to functional decline of the skin, with the removal action of the free radicals involved in peroxidation, based on the components of the study with superoxide dismutase (SOD) like activity, excellent in which we have developed a drug having anti-oxidative effect or free radical scavenging action. 本発明者らは種々研究を重ねた結果、サボテン類植物からの抽出物が優れた抗酸化作用と過酸化脂質生成抑制作用を有することを見いだして本発明を完成した。 The present inventors have result of various studies, and completed the present invention found to have an antioxidant effect and lipid peroxide formation inhibitory effects extract excellent from cactus crop plant.

【0004】 [0004]

【課題を解決するための手段】したがって本発明の皮膚化粧料は、有効成分として過酸化脂質生成抑制作用を有するサボテン類植物抽出物を含有することを特徴とする。 SUMMARY OF THE INVENTION Accordingly skin cosmetic of the present invention is characterized by containing a cactus crop plant extract having a lipid peroxide formation inhibitory action as the active ingredient. 本発明の皮膚化粧料は、該サボテン類植物抽出物のほかに更に他の過酸化脂質生成抑制作用を有することが知られている成分を併せて含有することができる。 Skin cosmetic of the present invention may contain together ingredients known to have still another lipid peroxide formation inhibitory action in addition to the cactus such plant extracts.

【0005】これまでサボテン類は、一般的に鑑賞用として栽培され、また、一部外国では食品として用いられてきた熱帯地方原産の多年生薬本で、肥厚した茎節を有することを特徴とする植物である。 [0005] cactus class so far, generally are grown as ornamental, also, some in the tropics native perennial drug book has been used as food in a foreign country, characterized by having a thickened stem clause it is a plant. 本発明のサボテン類抽出物の抽出方法としては、例えば、ウチワサボテンの茎部を主体とする全体を細断し、更にホモジナイザーにて半流動性のスラリー状の液体とし、これに種々の溶媒を加えて抽出する方法による。 As the method for extracting a cactus plant extract of the present invention, for example, chopped whole mainly stems of prickly pear, a semisolid slurry liquid more with a homogenizer, to which various solvents in addition according to the method of extraction. 抽出法は、室温で行ってもよいし、加温下ないし加熱下で行ってもよい。 Extraction method may be performed at room temperature, it may be carried out in warm under to heating under pressure. 抽出液は、必要に応じ遠心分離器等により固液分離して上清液をそのまま使用するか、またはその上清液を凍結乾燥器等にて溶媒を蒸発させ、このようにして得られる濃縮液成分もしくは固形物成分を皮膚化粧料基剤等に配合して本発明皮膚化粧料を得る。 Extract, Accept the supernatant by solid-liquid separation by a centrifugal separator or the like if necessary, or the solvent is evaporated at its supernatant freeze dryer or the like, the thus obtained concentrate obtaining a skin cosmetic preparation of the present invention the liquid component or solid component is blended in the skin cosmetic base or the like.

【0006】本発明に使用するサボテンの種類としては、モクキリン属 Peireskia、ウチワサボテン属 Opunt [0006] Examples of the type of cactus used in the present invention, Mokukirin genus Peireskia, prickly pear cactus species Opunt
ia、コチニールウチワサボテン属 Nopalea、シャコサボテン属Zygocactus、カニサボテン属 Shlumbergera 、クジャクサボテン属 Nopalxochia、イボサボテン属 Mammi ia, cochineal prickly pear cactus species Nopalea, giant cactus genus Zygocactus, crab cactus genus Shlumbergera, peacock cactus genus Nopalxochia, Ibosaboten genus Mammi
llaria、ウニサボテン属 Echinopsis 、ホシサボテン属 llaria, sea urchin cactus genus Echinopsis, Hoshi cactus species
Astrophytum、タマサボテン属 Echinocactus 、ハシラサボテン属 Cereus 、オキナサボテン属 Cephalocereu Astrophytum, Tama cactus genus Echinocactus, Hashirasaboten the genus Cereus, okina cactus species Cephalocereu
s 等のサボテン類があげられる。 Cactus such as s and the like.

【0007】抽出溶媒としては、水のほか、水溶性の溶媒であるエタノール、n−プロパノール、t−ブタノール、プロピレングリコール、1,3−ブチレングリコール等から選ばれる、1種または2種以上の単独あるいは混合溶媒があげられ、特に水または水性溶媒が好ましい。 [0007] The extraction solvent, addition of water, ethanol, or water-soluble solvents, n- propanol, t-butanol, propylene glycol, selected from 1,3-butylene glycol or the like, one or more single or a mixed solvent and the like, especially water or an aqueous solvent is preferred. 溶媒抽出物は、以後の操作を容易にするために必要に応じて濃縮あるいは濃縮乾固して使用するが、その際必要に応じて溶媒抽出物中に含まれるデンプンなどを常法により沈澱除去することもできる。 The solvent extract is used in was concentrated or concentrated to dryness as required to facilitate the subsequent operations, precipitation is removed by a conventional method such as starch contained in the solvent extract as necessary during its it is also possible to.

【0008】サボテン類植物の抽出物は、固形物として本発明皮膚化粧料中に 0.001〜10%(w/w)、好ましくは、0.01〜5.0 %(w/w)配合することができる。 [0008] cactus plant extract of plants, as in the present invention skin cosmetic 0.001~10% (w / w), preferably solid, it can be 0.01~5.0% (w / w) formulation.
本発明の皮膚化粧料の調製にあたっては、サボテン類植物抽出物の有する効果を損なわない範囲で、化粧品の基剤原料として慣用されるアルコール類、エステル類、界面活性剤、油脂類、ロウ類、炭化水素類、脂肪酸類等の原料を配合し、常法により所定の化粧料とすることができる。 In the preparation of the skin cosmetic of the present invention, within the range not impairing the effects possessed by the cactus such plant extracts, alcohols which are conventionally used as base materials of cosmetic products, esters, surfactants, fats and oils, waxes, hydrocarbons, blended raw materials such as fatty acids, may be predetermined cosmetic by conventional methods. 本発明の皮膚化粧料は、クリーム類、化粧水類、 Skin cosmetic composition of the present invention, creams, makeup water acids,
乳液類、パック類等の基礎化粧料、ファンデーション、 Milky lotion, foundation cosmetics such as packs such, foundation,
リップスティック等のメイクアップ化粧料、ヘアクリーム類、ヘアローション、シャンプー、リンス、ヘアートニック、養毛剤等の頭髪用化粧料、浴用剤等に配合することができる。 Makeup cosmetics such as lipstick, hair creams, hair lotion, shampoo, rinse, hair tonic, hair cosmetics such as hair tonic, can be incorporated into the bath agents, and the like.

【0009】本発明のサボテン類植物の抽出物は抗酸化作用及び過酸化脂質生成抑制作用を有することから、本発明はこれらを有効成分として含有する抗酸化剤及び過酸化脂質生成抑制剤にも関するものである。 [0009] cactus plant extract of a plant of the present invention has an antioxidant effect and lipid peroxide generation inhibitory effect, the present invention also antioxidants and lipid peroxide formation inhibitory agent containing them as active ingredient it relates.

【0010】本発明のサボテン類植物抽出物のin vitro [0010] The in vitro of cactus such plant extract of the present invention
の実験系による検討を行った。 It was examined by the experimental system. その方法として、リノレン酸への紫外線照射による過酸化脂質生成の実験系を用い、その抑制作用を過酸化脂質測定法の一つであるチオバルビツール酸法(TBA法)にて行った。 As a method, using an experimental system of lipid peroxidation by UV irradiation to linolenic acid, was the inhibitory action at thiobarbituric acid method which is one of the lipid peroxide assay (TBA method). その結果、 as a result,
本発明のサボテン類植物抽出物は、優れた過酸化脂質抑制作用があり、その有効性が証明された。 Cactus crop plant extract of the invention, has an excellent lipid peroxidation inhibitory effect, its effectiveness has been demonstrated. 更に、本発明サボテン類植物抽出物の有効性を検討するため、活性酸素(O 2 :スーパーオキサイドアニオン)の発生系にヒポキサンチン−キサンチンオキシデースを用い、その除去能(SOD活性)をニトロブル−テトラゾリウムのホルマザン形成阻害率を指標として実験を行ったところ、 Furthermore, in order to examine the effectiveness of the present invention cactus such plant extracts, active oxygen: hypoxanthine generation system (O 2 superoxide anion) - using xanthine oxy Desu, its ability to remove the (SOD activity) nitroblue - was subjected to experiments formazan formation inhibition rate of tetrazolium as an indicator,
優れた活性酸素除去作用があり、SOD作用としての有効性も合わせて証明された。 There are excellent active oxygen removing action was proven also to the efficacy of the SOD activity.

【0011】本発明サボテン類植物抽出物の in vivoの実験では、ハートレー系褐色モルモットの背部を毛刈及び剃毛した皮膚に紫外線を照射して、いわゆる日焼けを人工的に作る実験を行い、紅斑の発現時間及びその回復日数についての検討を行ったところ、照射前に本発明抽出液を塗布した部位は紅斑の発現が明らかに抑制された。 [0011] In in vivo experiments of the present invention cactus such plant extracts, is irradiated with ultraviolet rays to the back of Hartley brown guinea pig in hair cutting and shaved skin, we conducted an experiment to create a so-called tan artificially, erythema was examined for expression of the time and its recovery days, site coated with the present invention extract before irradiation expression of erythema was clearly inhibited. また、照射後に塗布した部位の紅斑消息時間は短縮され、その優れた有効性が証明された。 Also, erythema news time sites applied after irradiation is shortened, the superior efficacy was demonstrated.

【0012】また、上記のin vitro及び in vivoの実験を、本発明のサボテン類植物抽出物と過酸化脂質生成抑制作用があることが公知であるビタミンE、オウゴンエキス、アロエエキス等との複合混合物として行ったところ、上記各々の実験はともにサボテン類植物抽出物単独の場合に比べ有効性が約5〜15%高まる傾向が見られ、 [0012] The composite of the experiments described above in vitro and in vivo, cactus such plant extracts and vitamin E is known to have lipid peroxidation inhibitory effect of the present invention, Scutellaria root extract, aloe extract, and the like was performed as a mixture, each of the above experiments tended to both increased efficacy approximately 5-15% compared with the cactus crop plant extract alone,
本発明サボテン類植物抽出物は他の過酸化脂質生成抑制物質と相乗的にその効果を発揮することが実験的に証明された。 The present invention cactus such plant extracts have proved experimentally to exhibit synergistically the effect with other lipid peroxidation inhibitor.

【0013】 [0013]

【実施例】次に本発明を詳細に説明するため実施例をあげるが、本発明はこれに限定されるものではない。 EXAMPLES listed below examples to illustrate the present invention in detail, but the present invention is not limited thereto.

【0014】 実施例1 化粧用クリーム [組 成] [重量(%)] ミツロウ 6.0 セタノール 5.0 還元ラノリン 8.0 スクワラン 37.5 脂肪酸グリセリン 4.0 モノステアリン酸グリセリン 2.0 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 2.0 サボテン類植物抽出物(ウチワサボテン) 2.0 香 料 適 量 防腐剤、酸化防止剤 適 量 プロピレングリコール 5.0 精製水 にて全量 100ml とする。 [0014] Example 1 Cosmetic cream [pairs formed] [wt%] Beeswax 6.0 Cetyl alcohol 5.0 hydrogenated lanolin 8.0 Squalane 37.5 fatty acid glycerol 4.0 glycerol monostearate 2.0 polyoxy sorbitan monolaurate (20.E.O.) 2.0 cactus crop plant extract total amount at (Opuntia) 2.0 perfume qs preservatives, antioxidants qs propylene glycol 5.0 purified water and 100ml.

【0015】 実施例2 化粧用クリーム <他の過酸化脂質抑制成分との複合例> [組 成] [重量(%)] ミツロウ 6.0 セタノール 5.0 還元ラノリン 8.0 スクワラン 37.5 脂肪酸グリセリン 4.0 モノステアリン酸グリセリン 2.0 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 2.0 サボテン類植物抽出物(タマサボテン) 2.0 酢酸トコフェロール(過酸化脂質抑制成分) 0.5 香 料 適 量 防腐剤、酸化防止剤 適 量 プロピレングリコール 5.0 精製水 にて全量 100ml とする。 [0015] <composite example with other lipid peroxide inhibiting component> Example 2 Cosmetic cream [pairs formed] [wt%] Beeswax 6.0 Cetyl alcohol 5.0 hydrogenated lanolin 8.0 Squalane 37.5 fatty acid glycerol 4.0 glycerol monostearate 2.0 polyoxyethylene sorbitan monolaurate (20.E.O.) 2.0 cactus such plant extracts (Tama cactus) 2.0 tocopherol acetate (lipid peroxide inhibiting component) 0.5 perfume Appropriate amount preservative, up to a total volume of 100ml with antioxidants qs propylene glycol 5.0 purified water.

【0016】 実施例3 化粧水 [組 成] [重量(%)] グリセリン 5.0 プロピレングリコール 4.0 オレイルアルコール 0.1 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 1.5 ポリオキシエチレンラウリルエーテル 0.5 サボテン類植物抽出物(ウチワサボテン) 1.0 エタノール 10.0 香 料 適 量 防腐剤、酸化防止剤 適 量 精製水 にて全量 100ml とする。 [0016] Example 3 Lotion [pairs formed] [wt%] Glycerin 5.0 Propylene glycol 4.0 Oleyl alcohol 0.1 Polyoxyethylene sorbitan monolaurate (20.E.O.) 1.5 polyoxyethylene lauryl ether 0.5 cactus crop plant extract (Opuntia) 1.0 ethanol 10.0 perfume qs preservative, up to a total volume of 100ml with antioxidants qs purified water.

【0017】 実施例4 口 紅 [組 成] [重量(%)] ヒマシ油 48.8 ヘキサデシルアルコール 27.0 ラノリン 4.0 ミツロウ(黄色) 5.0 オゾケライト 4.0 キャンデリウロウ 7.0 カルナウバロウ 2.0 本発明サボテン類植物抽出物(ウチワサボテン) 1.0 防腐剤、酸化防止剤 適 量 酸化チタン 2.0 黄色202号 0.5 だいだい色211号 0.2 香 料 適 量 [0017] Example 4-necked red [pairs formed] [wt%] Castor oil 48.8 hexadecyl alcohol 27.0 Lanolin 4.0 Beeswax (yellow) 5.0 ozokerite 4.0 candelilla Urou 7.0 carnauba wax 2.0 invention cactus crop plant extract (Opuntia) 1.0 preservative, antioxidant q.s. titanium oxide 2.0 yellow No. 202 0.5 orange 211 No. 0.2 perfume q.s.

【0018】 実施例5 養毛剤 <他の過酸化脂質抑制成分との複合例> [組 成] [重量(%)] エタノール 6.0 エチニルエストラジオール 0.0004 d−パンテノール 0.2 イソプロピルメチルフェノール 0.1 塩酸ジフェンヒドラミン 0.01 プロピレングリコール 3.0 l−メントール 0.1 サボテン類植物抽出物(オキナサボテン) 1.0 アロエエキス(過酸化脂質抑制成分) 0.5 乳 酸 0.1 キレート剤 適 量 香 料 適 量 精製水 にて全量 100ml とする。 [0018] Example 5 tonic <composite example with other lipid peroxide inhibiting component> set formed] [wt%] ethanol 6.0 ethinylestradiol 0.0004 d-panthenol 0.2 isopropylmethylphenol 0 .1 diphenhydramine hydrochloride 0.01 propylene glycol 3.0 l-menthol 0.1 cactus such plant extracts (okina cactus) 1.0 aloe extract (lipid peroxide inhibiting component) 0.5 lactate 0.1 chelating agent suitable to a total volume of 100ml in an amount perfume Appropriate amount of purified water.

Claims (2)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 過酸化脂質生成抑制作用を有するサボテン類植物抽出物を含有することを特徴とする皮膚化粧料。 1. A skin cosmetic which is characterized by containing a cactus crop plant extract having a lipid peroxide formation inhibitory action.
  2. 【請求項2】 サボテン類植物抽出物と他の過酸化脂質生成抑制作用を有することが知られている成分と複合してなることを特徴とする請求項1記載の皮膚化粧料。 2. A cactus crop plant extract and other skin cosmetic of claim 1, wherein the is complexed with known components to have lipid peroxidation inhibitory effect.
JP8401493A 1993-03-18 1993-03-18 Cactus such plant extract-containing skin cosmetics Expired - Lifetime JP3484638B2 (en)

Priority Applications (1)

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JPH06271452A true true JPH06271452A (en) 1994-09-27
JP3484638B2 JP3484638B2 (en) 2004-01-06

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2798561A1 (en) * 1999-09-21 2001-03-23 Jean Morelle Compositions destinies in food and cosmetic use, characterized by their properties antilipoperoxydes
US6210738B1 (en) 1999-04-23 2001-04-03 E Excel Internatioanal Inc. Freeze-dried ginseng berry tea
US6238672B1 (en) 1999-04-23 2001-05-29 E. Excel International Inc. Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice
JP2002541872A (en) * 1999-04-23 2002-12-10 イー エクセル インターナショナル インコーポレイテッド Cactus fruit health products
US6524626B2 (en) 1999-04-23 2003-02-25 E Excel International, Inc. Ginseng berry topical products
US6576286B1 (en) 1999-04-23 2003-06-10 E Excel International Cactus fruit drinks and food products
US6737086B2 (en) * 1996-12-27 2004-05-18 Inovat S.A.R.L. Biologically active substances, method for obtaining and compositions containing them

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737086B2 (en) * 1996-12-27 2004-05-18 Inovat S.A.R.L. Biologically active substances, method for obtaining and compositions containing them
US6576286B1 (en) 1999-04-23 2003-06-10 E Excel International Cactus fruit drinks and food products
US6210738B1 (en) 1999-04-23 2001-04-03 E Excel Internatioanal Inc. Freeze-dried ginseng berry tea
US6238672B1 (en) 1999-04-23 2001-05-29 E. Excel International Inc. Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice
JP2002541872A (en) * 1999-04-23 2002-12-10 イー エクセル インターナショナル インコーポレイテッド Cactus fruit health products
US6524626B2 (en) 1999-04-23 2003-02-25 E Excel International, Inc. Ginseng berry topical products
FR2798561A1 (en) * 1999-09-21 2001-03-23 Jean Morelle Compositions destinies in food and cosmetic use, characterized by their properties antilipoperoxydes
WO2001021015A1 (en) * 1999-09-21 2001-03-29 Societe Cosper Compositions for use as food and in cosmetics characterised by their antilipoperoxidative properties

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