JPH06271452A - Skin cosmetic containing extract of plant of cactuses - Google Patents
Skin cosmetic containing extract of plant of cactusesInfo
- Publication number
- JPH06271452A JPH06271452A JP5084014A JP8401493A JPH06271452A JP H06271452 A JPH06271452 A JP H06271452A JP 5084014 A JP5084014 A JP 5084014A JP 8401493 A JP8401493 A JP 8401493A JP H06271452 A JPH06271452 A JP H06271452A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- hair
- cactus
- skin
- skin cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、皮膚外用剤組成物、更
に詳しくは皮膚の加齢あるいは日光暴露等による変化を
予防、改善する作用に優れ、また、安全性の高い皮膚化
粧料に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation composition, and more particularly to a dermatological cosmetic composition which is excellent in the action of preventing and improving changes due to aging of the skin or exposure to sunlight, and which is highly safe. Is.
【0002】[0002]
【従来の技術】皮膚化粧料組成物には種々の研究がこれ
までなされており、種々の薬効成分が配合されている。
皮膚の加齢や日光暴露等による変化は美容的に問題とな
ることから、その変化の予防や改善に優れた効能をもつ
化粧料や皮膚外用剤組成物が求められてきた。こうした
中で、これまで、各種の原料、例えばビタミン類、糖
類、脂質類等がその使用効果が特徴的であるため皮膚化
粧料に配合されてきた。2. Description of the Related Art Various studies have been conducted so far on skin cosmetic compositions, and various medicinal components are incorporated therein.
Since changes due to aging of the skin, exposure to sunlight, etc. are cosmetically problematic, cosmetics and external preparation compositions for skin having excellent effects in preventing and improving such changes have been demanded. Under such circumstances, various raw materials such as vitamins, sugars and lipids have been blended in skin cosmetics because of their characteristic use effects.
【0003】[0003]
【発明が解決しようとする課題】しかしながら、その効
果はいまだ十分でなく、より優れた効能をもち、且つ、
安全性の高い配合成分の開発が求められている。本発明
においては、皮膚の機能的低下をもたらす原因とされ
る、過酸化反応に関与するフリーラジカルの除去作用を
もつ、スーパーオキサイドディスムターゼ(SOD)様
活性を有する成分の研究に基づいて、優れた抗酸化作用
あるいはフリーラジカル除去作用を有する薬剤の開発を
行ったものである。本発明者らは種々研究を重ねた結
果、サボテン類植物からの抽出物が優れた抗酸化作用と
過酸化脂質生成抑制作用を有することを見いだして本発
明を完成した。However, the effect is not yet sufficient, and it has a superior effect, and
Development of highly safe compounding ingredients is required. In the present invention, based on research on a component having a superoxide dismutase (SOD) -like activity, which has an action of removing free radicals involved in a peroxidation reaction, which is a cause of functional deterioration of skin, This is the development of a drug having an antioxidant action or a free radical scavenging action. As a result of various studies, the present inventors have completed the present invention by discovering that an extract from a cactus plant has an excellent antioxidant effect and lipid peroxide production suppressing effect.
【0004】[0004]
【課題を解決するための手段】したがって本発明の皮膚
化粧料は、有効成分として過酸化脂質生成抑制作用を有
するサボテン類植物抽出物を含有することを特徴とす
る。本発明の皮膚化粧料は、該サボテン類植物抽出物の
ほかに更に他の過酸化脂質生成抑制作用を有することが
知られている成分を併せて含有することができる。Therefore, the skin cosmetic of the present invention is characterized by containing a cactus plant extract having a lipid peroxide production inhibitory action as an active ingredient. The skin cosmetic of the present invention may further contain other components known to have a lipid peroxide production inhibitory action in addition to the cactus plant extract.
【0005】これまでサボテン類は、一般的に鑑賞用と
して栽培され、また、一部外国では食品として用いられ
てきた熱帯地方原産の多年生薬本で、肥厚した茎節を有
することを特徴とする植物である。本発明のサボテン類
抽出物の抽出方法としては、例えば、ウチワサボテンの
茎部を主体とする全体を細断し、更にホモジナイザーに
て半流動性のスラリー状の液体とし、これに種々の溶媒
を加えて抽出する方法による。抽出法は、室温で行って
もよいし、加温下ないし加熱下で行ってもよい。抽出液
は、必要に応じ遠心分離器等により固液分離して上清液
をそのまま使用するか、またはその上清液を凍結乾燥器
等にて溶媒を蒸発させ、このようにして得られる濃縮液
成分もしくは固形物成分を皮膚化粧料基剤等に配合して
本発明皮膚化粧料を得る。[0005] Cactus is a perennial herb that is native to the tropics, which has been generally cultivated for appreciation and has been used as a food in some foreign countries. It is characterized by having thickened stem nodes. It is a plant. The extraction method of the cactus extract of the present invention, for example, shreds the whole of the stem part of the prickly pear cactus, and further into a semi-fluid slurry liquid with a homogenizer, to which various solvents are added. In addition, it depends on the extraction method. The extraction method may be carried out at room temperature or under heating or heating. The extract is solid-liquid separated by a centrifuge or the like if necessary, and the supernatant is used as it is, or the supernatant is evaporated in a lyophilizer or the like to evaporate the solvent and concentrated in this way. The liquid cosmetic or the solid component is mixed with a skin cosmetic base or the like to obtain the skin cosmetic of the present invention.
【0006】本発明に使用するサボテンの種類として
は、モクキリン属 Peireskia、ウチワサボテン属 Opunt
ia、コチニールウチワサボテン属 Nopalea、シャコサボ
テン属Zygocactus、カニサボテン属 Shlumbergera 、ク
ジャクサボテン属 Nopalxochia、イボサボテン属 Mammi
llaria、ウニサボテン属 Echinopsis 、ホシサボテン属
Astrophytum、タマサボテン属 Echinocactus 、ハシラ
サボテン属 Cereus 、オキナサボテン属 Cephalocereu
s 等のサボテン類があげられる。[0006] The types of cacti used in the present invention include Moire genus Peireskia and Opuntia genus Opunt.
ia, Cochineal Prickly Pear Cactus Nopalea, Mantis Cactus Zygocactus, Crab Cactus Shlumbergera, Peacock Cactus Nopalxochia, Wart Cactus Mammi
llaria, Sea urchin Cactus Echinopsis, Hoshi cactus
Astrophytum, Echinocactus spp., Cereus spp., Cephalocereu spp.
Examples include cacti such as s.
【0007】抽出溶媒としては、水のほか、水溶性の溶
媒であるエタノール、n−プロパノール、t−ブタノー
ル、プロピレングリコール、1,3−ブチレングリコー
ル等から選ばれる、1種または2種以上の単独あるいは
混合溶媒があげられ、特に水または水性溶媒が好まし
い。溶媒抽出物は、以後の操作を容易にするために必要
に応じて濃縮あるいは濃縮乾固して使用するが、その際
必要に応じて溶媒抽出物中に含まれるデンプンなどを常
法により沈澱除去することもできる。As the extraction solvent, in addition to water, one or two or more alone selected from water-soluble solvents such as ethanol, n-propanol, t-butanol, propylene glycol and 1,3-butylene glycol. Alternatively, a mixed solvent may be used, and water or an aqueous solvent is particularly preferable. The solvent extract may be concentrated or concentrated to dryness as needed to facilitate the subsequent operations. At that time, if necessary, starch and the like contained in the solvent extract may be removed by precipitation by a conventional method. You can also do it.
【0008】サボテン類植物の抽出物は、固形物として
本発明皮膚化粧料中に 0.001〜10%(w/w)、好まし
くは、0.01〜5.0 %(w/w)配合することができる。
本発明の皮膚化粧料の調製にあたっては、サボテン類植
物抽出物の有する効果を損なわない範囲で、化粧品の基
剤原料として慣用されるアルコール類、エステル類、界
面活性剤、油脂類、ロウ類、炭化水素類、脂肪酸類等の
原料を配合し、常法により所定の化粧料とすることがで
きる。本発明の皮膚化粧料は、クリーム類、化粧水類、
乳液類、パック類等の基礎化粧料、ファンデーション、
リップスティック等のメイクアップ化粧料、ヘアクリー
ム類、ヘアローション、シャンプー、リンス、ヘアート
ニック、養毛剤等の頭髪用化粧料、浴用剤等に配合する
ことができる。The cactus plant extract can be incorporated as a solid in the skin cosmetic of the present invention in an amount of 0.001 to 10% (w / w), preferably 0.01 to 5.0% (w / w).
In the preparation of the skin cosmetic of the present invention, alcohols, esters, surfactants, oils and fats, waxes, which are commonly used as a base material for cosmetics, within a range that does not impair the effects of the cactus plant extract, Raw materials such as hydrocarbons and fatty acids can be blended to obtain a predetermined cosmetic by a conventional method. The skin cosmetics of the present invention include creams, lotions,
Basic cosmetics such as emulsions and packs, foundations,
It can be added to makeup cosmetics such as lipsticks, hair creams, hair lotions, shampoos, rinses, hairnics, hair cosmetics such as hair nourishing agents, and bath agents.
【0009】本発明のサボテン類植物の抽出物は抗酸化
作用及び過酸化脂質生成抑制作用を有することから、本
発明はこれらを有効成分として含有する抗酸化剤及び過
酸化脂質生成抑制剤にも関するものである。Since the cactus plant extract of the present invention has an antioxidant action and a lipid peroxide production inhibitory action, the present invention also relates to an antioxidant and a lipid peroxide production inhibitor containing these as an active ingredient. It is related.
【0010】本発明のサボテン類植物抽出物のin vitro
の実験系による検討を行った。その方法として、リノレ
ン酸への紫外線照射による過酸化脂質生成の実験系を用
い、その抑制作用を過酸化脂質測定法の一つであるチオ
バルビツール酸法(TBA法)にて行った。その結果、
本発明のサボテン類植物抽出物は、優れた過酸化脂質抑
制作用があり、その有効性が証明された。更に、本発明
サボテン類植物抽出物の有効性を検討するため、活性酸
素(O2 :スーパーオキサイドアニオン)の発生系にヒ
ポキサンチン−キサンチンオキシデースを用い、その除
去能(SOD活性)をニトロブル−テトラゾリウムのホ
ルマザン形成阻害率を指標として実験を行ったところ、
優れた活性酸素除去作用があり、SOD作用としての有
効性も合わせて証明された。In vitro of the cactus plant extract of the present invention
The experiment system was examined. As the method, an experimental system for the production of lipid peroxide by UV irradiation of linolenic acid was used, and its inhibitory effect was performed by the thiobarbituric acid method (TBA method), which is one of the lipid peroxide measurement methods. as a result,
The cactus plant extract of the present invention has an excellent lipid peroxide inhibitory action, and its effectiveness has been proved. Furthermore, in order to examine the effectiveness of the cactus plant extract of the present invention, hypoxanthine-xanthine oxydase was used as a system for generating active oxygen (O 2 : superoxide anion), and its removal ability (SOD activity) was nitroble. When an experiment was conducted using the formazan formation inhibition rate of tetrazolium as an index,
It has an excellent action of removing active oxygen, and its effectiveness as an SOD action was also proved.
【0011】本発明サボテン類植物抽出物の in vivoの
実験では、ハートレー系褐色モルモットの背部を毛刈及
び剃毛した皮膚に紫外線を照射して、いわゆる日焼けを
人工的に作る実験を行い、紅斑の発現時間及びその回復
日数についての検討を行ったところ、照射前に本発明抽
出液を塗布した部位は紅斑の発現が明らかに抑制され
た。また、照射後に塗布した部位の紅斑消息時間は短縮
され、その優れた有効性が証明された。In the in vivo experiment of the cactus plant extract of the present invention, the skin of the back of Hartley brown guinea pig was shaved and shaved was irradiated with ultraviolet rays to artificially produce a so-called sunburn, and erythema Was examined and the number of days for recovery thereof was examined. As a result, the expression of erythema was clearly suppressed at the site to which the extract of the present invention was applied before irradiation. In addition, the erythema-flushing time of the site applied after irradiation was shortened, demonstrating its excellent efficacy.
【0012】また、上記のin vitro及び in vivoの実験
を、本発明のサボテン類植物抽出物と過酸化脂質生成抑
制作用があることが公知であるビタミンE、オウゴンエ
キス、アロエエキス等との複合混合物として行ったとこ
ろ、上記各々の実験はともにサボテン類植物抽出物単独
の場合に比べ有効性が約5〜15%高まる傾向が見られ、
本発明サボテン類植物抽出物は他の過酸化脂質生成抑制
物質と相乗的にその効果を発揮することが実験的に証明
された。[0012] The above in vitro and in vivo experiments were carried out by combining the cactus plant extract of the present invention with vitamin E, sardine extract, aloe extract, etc., which are known to have a lipid peroxide production inhibitory action. When carried out as a mixture, each of the above-mentioned experiments shows a tendency that the efficacy is increased by about 5 to 15% as compared with the case of using the cactus plant extract alone,
It was experimentally proved that the cactus plant extract of the present invention synergistically exerts its effect with other lipid peroxide production-inhibiting substances.
【0013】[0013]
【実施例】次に本発明を詳細に説明するため実施例をあ
げるが、本発明はこれに限定されるものではない。EXAMPLES Next, examples will be given to explain the present invention in detail, but the present invention is not limited thereto.
【0014】 実施例1 化粧用クリーム [組 成] [重量(%)] ミツロウ 6.0 セタノール 5.0 還元ラノリン 8.0 スクワラン 37.5 脂肪酸グリセリン 4.0 モノステアリン酸グリセリン 2.0 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 2.0 サボテン類植物抽出物(ウチワサボテン) 2.0 香 料 適 量 防腐剤、酸化防止剤 適 量 プロピレングリコール 5.0 精製水 にて全量 100ml とする。 Example 1 Cosmetic Cream [Composition] [Weight (%)] Beeswax 6.0 Cetanol 5.0 Reduced Lanolin 8.0 Squalane 37.5 Fatty Acid Glycerin 4.0 Glycerin Monostearate 2.0 Polyoxy Ethylene sorbitan monolaurate (20.EO) 2.0 Cactus plant extract (prickly pear cactus) 2.0 Fragrance suitable amount Preservative, antioxidant suitable amount Propylene glycol 5.0 Complete amount with purified water Make 100 ml.
【0015】 実施例2 化粧用クリーム <他の過酸化脂質抑制成分との複合例> [組 成] [重量(%)] ミツロウ 6.0 セタノール 5.0 還元ラノリン 8.0 スクワラン 37.5 脂肪酸グリセリン 4.0 モノステアリン酸グリセリン 2.0 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 2.0 サボテン類植物抽出物(タマサボテン) 2.0 酢酸トコフェロール(過酸化脂質抑制成分) 0.5 香 料 適 量 防腐剤、酸化防止剤 適 量 プロピレングリコール 5.0 精製水 にて全量 100ml とする。 Example 2 Cosmetic Cream <Composite Example with Other Lipid Peroxide Inhibiting Component> [Composition] [Weight (%)] Beeswax 6.0 Cetanol 5.0 Reduced Lanolin 8.0 Squalane 37.5 Fatty Acid Glycerin 4.0 Glycerin monostearate 2.0 Polyoxyethylene sorbitan Monolaurate (20.EO) 2.0 Cactus plant extract (Tama cactus) 2.0 Tocopherol acetate (a component to suppress lipid peroxide) 0.5 Perfume Appropriate amount Preservative, Antioxidant Appropriate amount Propylene glycol 5.0 Make up to 100 ml with purified water.
【0016】 実施例3 化粧水 [組 成] [重量(%)] グリセリン 5.0 プロピレングリコール 4.0 オレイルアルコール 0.1 ポリオキシエチレンソルビタン モノラウリン酸エステル(20.E.O.) 1.5 ポリオキシエチレンラウリルエーテル 0.5 サボテン類植物抽出物(ウチワサボテン) 1.0 エタノール 10.0 香 料 適 量 防腐剤、酸化防止剤 適 量 精製水 にて全量 100ml とする。 Example 3 Lotion [Composition] [Weight (%)] Glycerin 5.0 propylene glycol 4.0 oleyl alcohol 0.1 polyoxyethylene sorbitan monolaurate (20.EO.) 1.5 Polyoxyethylene lauryl ether 0.5 Cactus plant extract (prickly pear cactus) 1.0 Ethanol 10.0 Fragrance appropriate amount Preservative, antioxidant appropriate amount Purified water to make a total volume of 100 ml.
【0017】 実施例4 口 紅 [組 成] [重量(%)] ヒマシ油 48.8 ヘキサデシルアルコール 27.0 ラノリン 4.0 ミツロウ(黄色) 5.0 オゾケライト 4.0 キャンデリウロウ 7.0 カルナウバロウ 2.0 本発明サボテン類植物抽出物(ウチワサボテン) 1.0 防腐剤、酸化防止剤 適 量 酸化チタン 2.0 黄色202号 0.5 だいだい色211号 0.2 香 料 適 量 Example 4 Lipstick [Composition] [Weight (%)] Castor oil 48.8 Hexadecyl alcohol 27.0 Lanolin 4.0 Beeswax (yellow) 5.0 Ozokerite 4.0 Candeliu 7.0 Carnauba wax 2.0 Cactus plant extract of the present invention (prickly pear cactus) 1.0 Preservative, antioxidant suitable amount Titanium oxide 2.0 Yellow No. 202 0.5 Daidai color No. 211 0.2 Fragrance suitable amount
【0018】 実施例5 養毛剤 <他の過酸化脂質抑制成分との複合例> [組 成] [重量(%)] エタノール 6.0 エチニルエストラジオール 0.0004 d−パンテノール 0.2 イソプロピルメチルフェノール 0.1 塩酸ジフェンヒドラミン 0.01 プロピレングリコール 3.0 l−メントール 0.1 サボテン類植物抽出物(オキナサボテン) 1.0 アロエエキス(過酸化脂質抑制成分) 0.5 乳 酸 0.1 キレート剤 適 量 香 料 適 量 精製水 にて全量 100ml とする。Example 5 Hair Growth Agent <Composite Example with Other Lipid Peroxide Inhibiting Component> [Composition] [Weight (%)] Ethanol 6.0 Ethynyl estradiol 0.0004 d-Panthenol 0.2 Isopropylmethylphenol 0 1 Diphenhydramine hydrochloride 0.01 Propylene glycol 3.0 l-menthol 0.1 Cactus plant extract (Okina cactus) 1.0 Aloe extract (lipid peroxide inhibitor) 0.5 Lactic acid 0.1 Chelating agent Suitable Quantity Fragrance Appropriate quantity Make up to 100 ml with purified water.
Claims (2)
ン類植物抽出物を含有することを特徴とする皮膚化粧
料。1. A skin cosmetic comprising a cactus plant extract having an inhibitory effect on lipid peroxide production.
生成抑制作用を有することが知られている成分と複合し
てなることを特徴とする請求項1記載の皮膚化粧料。2. The skin cosmetic composition according to claim 1, wherein the cactus plant extract is combined with another component known to have a lipid peroxide production inhibitory action.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP08401493A JP3484638B2 (en) | 1993-03-18 | 1993-03-18 | Cactus plant extract-containing skin cosmetics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP08401493A JP3484638B2 (en) | 1993-03-18 | 1993-03-18 | Cactus plant extract-containing skin cosmetics |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06271452A true JPH06271452A (en) | 1994-09-27 |
JP3484638B2 JP3484638B2 (en) | 2004-01-06 |
Family
ID=13818729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP08401493A Expired - Lifetime JP3484638B2 (en) | 1993-03-18 | 1993-03-18 | Cactus plant extract-containing skin cosmetics |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3484638B2 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08333260A (en) * | 1995-06-06 | 1996-12-17 | Kaminomoto Honpo:Kk | Skin preparation for external use |
FR2798561A1 (en) * | 1999-09-21 | 2001-03-23 | Jean Morelle | COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES |
US6210738B1 (en) | 1999-04-23 | 2001-04-03 | E Excel Internatioanal Inc. | Freeze-dried ginseng berry tea |
US6238672B1 (en) | 1999-04-23 | 2001-05-29 | E. Excel International Inc. | Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice |
JP2002541872A (en) * | 1999-04-23 | 2002-12-10 | イー エクセル インターナショナル インコーポレイテッド | Cactus fruit health products |
US6524626B2 (en) | 1999-04-23 | 2003-02-25 | E Excel International, Inc. | Ginseng berry topical products |
US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
US6737086B2 (en) * | 1996-12-27 | 2004-05-18 | Inovat S.A.R.L. | Biologically active substances, method for obtaining and compositions containing them |
KR100435855B1 (en) * | 2001-09-13 | 2004-06-12 | 주식회사 태평양 | Composition for external application to the skin containing Opuntia ficus-indica extract |
WO2019123893A1 (en) * | 2017-12-20 | 2019-06-27 | Shiodaライフサイエンス株式会社 | Method for producing antioxidant or hair growth stimulant, and antioxidant or hair growth stimulant produced thereby |
-
1993
- 1993-03-18 JP JP08401493A patent/JP3484638B2/en not_active Expired - Lifetime
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08333260A (en) * | 1995-06-06 | 1996-12-17 | Kaminomoto Honpo:Kk | Skin preparation for external use |
US6737086B2 (en) * | 1996-12-27 | 2004-05-18 | Inovat S.A.R.L. | Biologically active substances, method for obtaining and compositions containing them |
US6210738B1 (en) | 1999-04-23 | 2001-04-03 | E Excel Internatioanal Inc. | Freeze-dried ginseng berry tea |
US6238672B1 (en) | 1999-04-23 | 2001-05-29 | E. Excel International Inc. | Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice |
JP2002541872A (en) * | 1999-04-23 | 2002-12-10 | イー エクセル インターナショナル インコーポレイテッド | Cactus fruit health products |
US6524626B2 (en) | 1999-04-23 | 2003-02-25 | E Excel International, Inc. | Ginseng berry topical products |
US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
FR2798561A1 (en) * | 1999-09-21 | 2001-03-23 | Jean Morelle | COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES |
WO2001021015A1 (en) * | 1999-09-21 | 2001-03-29 | Societe Cosper | Compositions for use as food and in cosmetics characterised by their antilipoperoxidative properties |
KR100435855B1 (en) * | 2001-09-13 | 2004-06-12 | 주식회사 태평양 | Composition for external application to the skin containing Opuntia ficus-indica extract |
WO2019123893A1 (en) * | 2017-12-20 | 2019-06-27 | Shiodaライフサイエンス株式会社 | Method for producing antioxidant or hair growth stimulant, and antioxidant or hair growth stimulant produced thereby |
JPWO2019123893A1 (en) * | 2017-12-20 | 2020-12-24 | Shiodaライフサイエンス株式会社 | A method for producing an antioxidant or a hair restorer, and an antioxidant or a hair restorer produced by the production method. |
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