JPH06271452A - Skin cosmetic containing extract of plant of cactuses - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic comprising an extract from a plant of cactuses as an active ingredient. CONSTITUTION:A skin cosmetic comprises an extract from a plant of cactuses having antioxidant action and/or inhibitory action on formation of lipoperoxide and optionally a well-known component having inhibitory action on formation of lipoperoxide as active ingredients. Since the extract has excellently preventing and improving action on change in skin by aging or exposure to sunlight and is an extract from a naturally-occurring material. Cosmetics such as creams, toilet lotions and milky lotions, cosmetic for hair such as hair creams, hair lotions, shampoos, rinses, hair tonics and hair nourishing agents, bathing agents, etc., having excellent safety are obtained.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation composition, and more particularly to a dermatological cosmetic composition which is excellent in the action of preventing and improving changes due to aging of the skin or exposure to sunlight, and which is highly safe. Is.

[0002]

2. Description of the Related Art Various studies have been conducted so far on skin cosmetic compositions, and various medicinal components are incorporated therein.
Since changes due to aging of the skin, exposure to sunlight, etc. are cosmetically problematic, cosmetics and external preparation compositions for skin having excellent effects in preventing and improving such changes have been demanded. Under such circumstances, various raw materials such as vitamins, sugars and lipids have been blended in skin cosmetics because of their characteristic use effects.

[0003]

However, the effect is not yet sufficient, and it has a superior effect, and
Development of highly safe compounding ingredients is required. In the present invention, based on research on a component having a superoxide dismutase (SOD) -like activity, which has an action of removing free radicals involved in a peroxidation reaction, which is a cause of functional deterioration of skin, This is the development of a drug having an antioxidant action or a free radical scavenging action. As a result of various studies, the present inventors have completed the present invention by discovering that an extract from a cactus plant has an excellent antioxidant effect and lipid peroxide production suppressing effect.

[0004]

Therefore, the skin cosmetic of the present invention is characterized by containing a cactus plant extract having a lipid peroxide production inhibitory action as an active ingredient. The skin cosmetic of the present invention may further contain other components known to have a lipid peroxide production inhibitory action in addition to the cactus plant extract.

[0005] Cactus is a perennial herb that is native to the tropics, which has been generally cultivated for appreciation and has been used as a food in some foreign countries. It is characterized by having thickened stem nodes. It is a plant. The extraction method of the cactus extract of the present invention, for example, shreds the whole of the stem part of the prickly pear cactus, and further into a semi-fluid slurry liquid with a homogenizer, to which various solvents are added. In addition, it depends on the extraction method. The extraction method may be carried out at room temperature or under heating or heating. The extract is solid-liquid separated by a centrifuge or the like if necessary, and the supernatant is used as it is, or the supernatant is evaporated in a lyophilizer or the like to evaporate the solvent and concentrated in this way. The liquid cosmetic or the solid component is mixed with a skin cosmetic base or the like to obtain the skin cosmetic of the present invention.

[0006] The types of cacti used in the present invention include Moire genus Peireskia and Opuntia genus Opunt.
ia, Cochineal Prickly Pear Cactus Nopalea, Mantis Cactus Zygocactus, Crab Cactus Shlumbergera, Peacock Cactus Nopalxochia, Wart Cactus Mammi
llaria, Sea urchin Cactus Echinopsis, Hoshi cactus
Astrophytum, Echinocactus spp., Cereus spp., Cephalocereu spp.
Examples include cacti such as s.

As the extraction solvent, in addition to water, one or two or more alone selected from water-soluble solvents such as ethanol, n-propanol, t-butanol, propylene glycol and 1,3-butylene glycol. Alternatively, a mixed solvent may be used, and water or an aqueous solvent is particularly preferable. The solvent extract may be concentrated or concentrated to dryness as needed to facilitate the subsequent operations. At that time, if necessary, starch and the like contained in the solvent extract may be removed by precipitation by a conventional method. You can also do it.

The cactus plant extract can be incorporated as a solid in the skin cosmetic of the present invention in an amount of 0.001 to 10% (w / w), preferably 0.01 to 5.0% (w / w).
In the preparation of the skin cosmetic of the present invention, alcohols, esters, surfactants, oils and fats, waxes, which are commonly used as a base material for cosmetics, within a range that does not impair the effects of the cactus plant extract, Raw materials such as hydrocarbons and fatty acids can be blended to obtain a predetermined cosmetic by a conventional method. The skin cosmetics of the present invention include creams, lotions,
Basic cosmetics such as emulsions and packs, foundations,
It can be added to makeup cosmetics such as lipsticks, hair creams, hair lotions, shampoos, rinses, hairnics, hair cosmetics such as hair nourishing agents, and bath agents.

Since the cactus plant extract of the present invention has an antioxidant action and a lipid peroxide production inhibitory action, the present invention also relates to an antioxidant and a lipid peroxide production inhibitor containing these as an active ingredient. It is related.

In vitro of the cactus plant extract of the present invention
The experiment system was examined. As the method, an experimental system for the production of lipid peroxide by UV irradiation of linolenic acid was used, and its inhibitory effect was performed by the thiobarbituric acid method (TBA method), which is one of the lipid peroxide measurement methods. as a result,
The cactus plant extract of the present invention has an excellent lipid peroxide inhibitory action, and its effectiveness has been proved. Furthermore, in order to examine the effectiveness of the cactus plant extract of the present invention, hypoxanthine-xanthine oxydase was used as a system for generating active oxygen (O ₂ : superoxide anion), and its removal ability (SOD activity) was nitroble. When an experiment was conducted using the formazan formation inhibition rate of tetrazolium as an index,
It has an excellent action of removing active oxygen, and its effectiveness as an SOD action was also proved.

In the in vivo experiment of the cactus plant extract of the present invention, the skin of the back of Hartley brown guinea pig was shaved and shaved was irradiated with ultraviolet rays to artificially produce a so-called sunburn, and erythema Was examined and the number of days for recovery thereof was examined. As a result, the expression of erythema was clearly suppressed at the site to which the extract of the present invention was applied before irradiation. In addition, the erythema-flushing time of the site applied after irradiation was shortened, demonstrating its excellent efficacy.

[0012] The above in vitro and in vivo experiments were carried out by combining the cactus plant extract of the present invention with vitamin E, sardine extract, aloe extract, etc., which are known to have a lipid peroxide production inhibitory action. When carried out as a mixture, each of the above-mentioned experiments shows a tendency that the efficacy is increased by about 5 to 15% as compared with the case of using the cactus plant extract alone,
It was experimentally proved that the cactus plant extract of the present invention synergistically exerts its effect with other lipid peroxide production-inhibiting substances.

[0013]

EXAMPLES Next, examples will be given to explain the present invention in detail, but the present invention is not limited thereto.

Example 1 Cosmetic Cream [Composition] [Weight (%)] Beeswax 6.0 Cetanol 5.0 Reduced Lanolin 8.0 Squalane 37.5 Fatty Acid Glycerin 4.0 Glycerin Monostearate 2.0 Polyoxy Ethylene sorbitan monolaurate (20.EO) 2.0 Cactus plant extract (prickly pear cactus) 2.0 Fragrance suitable amount Preservative, antioxidant suitable amount Propylene glycol 5.0 Complete amount with purified water Make 100 ml.

Example 2 Cosmetic Cream <Composite Example with Other Lipid Peroxide Inhibiting Component> [Composition] [Weight (%)] Beeswax 6.0 Cetanol 5.0 Reduced Lanolin 8.0 Squalane 37.5 Fatty Acid Glycerin 4.0 Glycerin monostearate 2.0 Polyoxyethylene sorbitan Monolaurate (20.EO) 2.0 Cactus plant extract (Tama cactus) 2.0 Tocopherol acetate (a component to suppress lipid peroxide) 0.5 Perfume Appropriate amount Preservative, Antioxidant Appropriate amount Propylene glycol 5.0 Make up to 100 ml with purified water.

Example 3 Lotion [Composition] [Weight (%)] Glycerin 5.0 propylene glycol 4.0 oleyl alcohol 0.1 polyoxyethylene sorbitan monolaurate (20.EO.) 1.5 Polyoxyethylene lauryl ether 0.5 Cactus plant extract (prickly pear cactus) 1.0 Ethanol 10.0 Fragrance appropriate amount Preservative, antioxidant appropriate amount Purified water to make a total volume of 100 ml.

Example 4 Lipstick [Composition] [Weight (%)] Castor oil 48.8 Hexadecyl alcohol 27.0 Lanolin 4.0 Beeswax (yellow) 5.0 Ozokerite 4.0 Candeliu 7.0 Carnauba wax 2.0 Cactus plant extract of the present invention (prickly pear cactus) 1.0 Preservative, antioxidant suitable amount Titanium oxide 2.0 Yellow No. 202 0.5 Daidai color No. 211 0.2 Fragrance suitable amount

Example 5 Hair Growth Agent <Composite Example with Other Lipid Peroxide Inhibiting Component> [Composition] [Weight (%)] Ethanol 6.0 Ethynyl estradiol 0.0004 d-Panthenol 0.2 Isopropylmethylphenol 0 1 Diphenhydramine hydrochloride 0.01 Propylene glycol 3.0 l-menthol 0.1 Cactus plant extract (Okina cactus) 1.0 Aloe extract (lipid peroxide inhibitor) 0.5 Lactic acid 0.1 Chelating agent Suitable Quantity Fragrance Appropriate quantity Make up to 100 ml with purified water.

Claims (2)

[Claims] 1. A skin cosmetic comprising a cactus plant extract having an inhibitory effect on lipid peroxide production. 2. The skin cosmetic composition according to claim 1, wherein the cactus plant extract is combined with another component known to have a lipid peroxide production inhibitory action.