JP2003073287A - Hyaluronidase activity inhibitor or cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new safe hyaluronidase activity inhibitor or cosmetic composition. SOLUTION: The hyaluronidase activity inhibitor or cosmetic composition contains an extract of one or more vegetables selected from Kokemomo (Vaccinium vitis-idaea L.) and Tarayou (Ilexlatifolia Thunb.). The composition has hyaluronidase activity inhibiting action and is effective for improving the springiness, luster, crease and sag of the skin and ameliorating inflammatory skin diseases such as eczema, itchiness and roughened skin. Accordingly, the composition is effective for preventing the aging or inflammation of the skin.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to application to a hyaluronidase activity inhibitor or cosmetic composition containing one or more plant extracts selected from cowberry and tarayo.

[0002]

2. Description of the Related Art A typical change in human skin aging is wrinkles and tarmi, which is one of the major skin problems for older people and women. However, at present, most effective treatments for skin wrinkles and tarmi are not found, and various studies on aging have come to be conducted in the aging society.

At present, it is considered that the formation of wrinkles and tarmi on human skin is caused by the decrease in elasticity of the skin. However, specific histological phenomena include changes in extracellular matrix components such as collagen, elastin, and glycosaminoglycans in the dermis. Among them, hyaluronic acid is particularly connective tissue. It is known as a high-molecular-weight polysaccharide widely distributed in the skin, retains a large amount of water in the skin, and has a gel form. Therefore, it is considered that qualitative and quantitative reduction of hyaluronic acid is important in skin aging.

Further, hyaluronic acid is also an important factor for skin inflammation, and it is known that hyaluronidase, an enzyme that hydrolyzes hyaluronic acid, is present. That is, it is considered that hyaluronidase is activated during inflammation, destroys the connective tissue matrix such as hyaluronic acid, and enhances the permeability of cells and blood vessels of the inflammatory system, which is a cause of acute edema. Since it is also used as an agent, inhibiting the activity of hyaluronidase is considered to be effective in preventing skin inflammation.

[0005]

Therefore, the present invention suppresses the activity of hyaluronidase to reduce the water retention function of the skin caused by the decomposition of hyaluronic acid, the skin elasticity / tension / gloss, and the wrinkles and tarmi. It is an object of the present invention to provide an inhibitor of hyaluronidase activity, which is effective in preventing skin aging or skin inflammation, which is said to cause formation or inflammatory skin diseases (eg, eczema, pruritus, rough skin, etc.).

[0006]

In view of these circumstances, the present inventors have made the development of useful plants having a hyaluronidase activity inhibitory action, and as a result, one or more plant extracts selected from cowberry and tarayo. Confirmed that the activity of hyaluronidase was significantly suppressed. And since it prevents the degradation of hyaluronic acid distributed in connective tissue,
Applying tension and luster to the skin, or improving wrinkles and lumps. Furthermore, the present invention has been completed by providing a safe hyaluronidase activity inhibitor or a cosmetic composition that also improves inflammatory skin diseases (eg, eczema, pruritus, rough skin, etc.).

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION It should be noted that "the cowberry used in the present invention
(Also known as moss) "means Ericaceae, Vaccinium
(Vaccinium) plants: cowberry (Vaccinium vitis-idaea
L.) flower, spike, pericarp, fruit, stem, leaf, branch, branch, stem,
Bark, rhizome, root bark, roots, seeds or whole plants are used, but in addition, rabbit eye blueberry (V.ashei Rea
de.), Highbush Blueberry (V. australe Smal
l.), bilberry (V.myrtillus L.), black buckthorn (V.ul)
iginosum L.), cranberry (V. macrocarpon Ait.), low bush blueberry (V. angustifolium Ait.) and the like can also be used.

Further, the "Tarayo (also known as:
`` Ichiyocha, bitchocha, bittergreen tea) '' is the Aquifoli family.
aceae), plants of the genus Ilex (Ilex): Tarayou (Large leaf winter blue)
(Ilexlatifolia Thunb.) Flower, spike, pericarp, fruit, stem,
Leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other species of the same genus, such as I. macropoda
Miq.), Red-spotted boxwood (I. sugerokii var. Brevipedu)
nculata S. Hu), Amami Holly (I. dimorphophyll)
a), American Holly (I.opaca Ait.), Boxwood `` I.cre
nata var.crenata (= I.crenata Thunb.) 」, Irex
I. vomitoria, Ilex guayusa (I.gu)
ayusa), Ushikaba (black soybean) (I.sugerokii Max.), Udonoki (I.serrata Thunb.), black ganemochi (iron winter blue)
(I.rotunda Thunb.)
Hook.et Arm.), Fine-grained winter blue (I.rotunda Thunb.var.microc
arpa SYHu), mountain green tea (Hainan winter blue) (I.hainanensis Mer
r.), China Holly Mochi (Holly Mochi, phalanx) (I. cornut
a Lindl.et Paxt.), Holly (I. aquifoliu)
m), Soyogo (I. pedunculosa Miq.), Tamamizuki (green cherry peach, trichomes winter blue) (I. micrococca Maxim.f.pilosa SY
Hu), Tsurugusuge (I. rugosa), Nagabyuutsugushi (I. maximowi)
cziana), Solanum vulgaris (Solanum japonica, Kashinohamochi, winter blue) `` I. chinensis Sims (= I.oldhamii Miq.) '', Hyuga-tsutsumi (I. crenata var.
(I.geniculata), Yerba mate (Paraguaycha) `` I.paraguaiens
is A.St.Hil. (= I.paraguayensis St.Hill. = I.paraguar
iensis) '', Manjusei (Morning Lee Fuyusei) (I.aculeolata Nakai), Miyama buckthorn (I.nipponica), Ichinoki (I.integra Th)
unb.), Kangmei (Umeba Fuyusei) (I.asprella Champ.ex Bent
h.), I.kudingcha CJTseng, etc. can also be used.

The extract of cowberry and tarajo used in the present invention means various parts of each plant (flower, spike, peel,
Fruit, stem, leaf, branch, foliage, stem, bark, rhizome, root bark, root,
Seed or whole grass) as it is or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those obtained by hydrolyzing with acid / alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure. After extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The various plant extracts of cowberry and tarajo of the present invention can be contained in a hyaluronidase activity inhibitor and a cosmetic composition, and the content thereof is not particularly limited, and the hyaluronidase activity inhibitor and the cosmetic composition are not specified. Slightly different depending on the type, quality and expected degree of action,
Usually, 0.0001 mass% or more (hereinafter, represented by%), preferably 0.01 to 50.0% in terms of solid content in the total amount of the preparation is preferable. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The hyaluronidase activity inhibitor and cosmetic composition of the present invention may have any dosage form and form, such as capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments and sheets. It can be mixed and used in the form.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) For baths to be used Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpastes, mouthwash, mouthwashes and the like.

The hyaluronidase activity inhibitor and cosmetic composition of the present invention may contain, in addition to the above-mentioned essential components, the components and additives exemplified below as needed within the range not impairing the effects of the present invention. Can be selected and used in combination, the content in the formulation is not particularly specified, but usually,
0.0001 to 50% is preferable.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide. Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol or isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir oak, Uruushi, Unshu Mikan (Chenhide), Umbo, Estragon, Ezokogi (Ezo Goka), Ezo lily of the valley, Echinashi (Hosobamurasakibarenguiku), Enishida, Enokitake
(Enoki mushroom), Ebisugusa or Cassia tora (Kaimeiko), Elcampre, Elderberry "fruit", Elemi, Eringi or pre-lotus erinji, Enju (Sophoraceae, Sophoraceae rice), Pea, Ougi or Kibananagi (Yellow) , Narco lily or Kagyurumabanaruco lily (yellow sperm), Spruce sasayuki or sasanoyuki, lauren (yellow lantern), Ogatha Houken, Okarasuri (carocon), Ooguruma (civil engineering incense), Otsutsurafuji (self-defense), psyllium, car vegetation, car-plant Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana okera or Okera (white oak), Obana Salva peri (banaba), Obayashishabushi "fruits", Ooha-shio-sa, Ome-shi-o-sa (Osaka-noshikosa) Hawthorn or hawthorn (mountain cricket), honey palm, barley (barley), oca, okazeri (Jabiko), okra `` fruit '', oguruma (overturning), okururigogotai (Usushu leaked, indigo head), Panax ginseng or Panax ginseng (Ginseng), Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (Brother's cut grass), Odorikosou (Intermittent), Onamomi (blue ear), Oniguru, Onidokoro or Tokoro or Nagadokoro (Haikai), Oninoyagara (Tianma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Ohio (Ryoku-noha), Ominaeshi (defeat) Soy), oyuko,
Dutch mustard (cresson), Dutch jelly, Dutch juniper, Dutch honeywort, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp", cauliflower (ripe ground yellow), cacao "fruit, pericarp, seed", oyster ( Persimmon "leaf"), Kagizura (fishing hook), Kakidoshi or Kantorisou (Lotus grass), Kakiran, Gaku hydrangea, Cassia, Casinoki (楮 fruit "fruit"), Gakutu (muddle), Kashiwa (hammer tree, mallet) Leaf), Cascarilla, Cascara Sagrada, Gypsophila, Kasengou, Crabgrass (Kanshato), Kaniwa, Carnation, Valerian (Cowleaf), Hippopotamus, Birch, Birch, Gerbera, Pumpkin, Kapok “Seeds”, Kahoksansho (Shosho), Gama (yellow), chamomile or Roman chamomile, chamomile (grass), cam cam
(Duck), color, swordfish, crow cucumber or cinnamon cucumber (king melon), crow bishaku (half-summer), oats, guarana `` seed '', callahoo (bamboo), karaya, garyu, karin (wood melon), garcinia, kawamidori, kawarasaiko (Koryo greens, white grass), kawajisha, kawaratake, kawaranadeshiko (ishitake) or ezokawaranadeshiko (green oats, barley malt), kawaran carrots (green cabbage), kawara mugwort (sea peony), kansui (sweetened), kanzo (kanzo). Licorice), cantara, candilla, canto, canna, cannabis, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry, european raspberry),
Kiwi "fruit, leaves", squid cucumber (urine root), kyokyo
(Kikyo, Kikyo root), chrysanthemum (Chrysanthemum, chrysanthemum, chrysanthemum), Kikutanigiku, Catalpa (Azusa fruit), Rumex
(Yotei), Kizitsu (Kuromi), Kizuta, Kidachi Aloe, Kudachi Mint, Kina, Kinonaki (Shinkona, Red Kinaki), Quinua (Kinoa), Kihada (Yellow Kashiwa), Kimame, Gymnema sylvestre, Kimenkaku, cabbage, cabbage "unripe fruit" , Caraway, cucumber, gyoryu (Nishikawayanagi, Teiyanagi), Kiraja saponaria, Kiraya, Kiranso (Kenshi small grass), kumquat "fruit", kinkju, ginsekikai, kumbusen, kimuma, kimimizuki (senzuru kusa),
Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruit", Guayule, Quercus Infectria (galaxy), Kukui nuts, Kugenumaran, Cuco (lilies, limbs, limbs, cicadas), Kusagikazura Kudzu (Kudzu root), camphor tree, gooseberry "fruit", Xantheng carrot (Yellow lance), Kutiti River, Gardenia (Yamasuko), Kunugi (Garden root), Cupua, Kubeba, Kumazasa, Vermella, Clara (bitter) three),
Chestnut "seed, fruit, astringent skin", Curculigo latifolia "fruit", grapefruit "fruit / leaves", buckthorn, turtle buckthorn, turtle beetle or black beetle or fluffy leaf (prolonged grass), clove (clove, clove), gumbainasuna (sekimei, sekimeishi), Keigai (Peonymus esculenta, Paeonia spp.), Keitou (Corolla flower, Colander), Geckavidin, Bay Bay (Laurel), Kenashisartoriibara (Earth peony, mountain return), Gentiana, Geno-shouko (Old bird grass), Kempushi (Kishigushi), Kukushiku Citrus unshiu (Koji, Tachibana, Obenimikan, Fukuromican, Sagamikouji, Ponkan, Santara (Tachibana peel)), Koushinbara (monthly flower), Kousuihakka, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon ( (Straw book, Karamoto book), Kouryan, Koryokyo (Kora ginger), Endoro "fruit", Koouren (Ebisukiren), Scutellaria (yellow Gon), coconut "fruit", tetradium ruticarpum (Wu Fructus), Goshoichigo (bokbunja), pepper (pepper), cosmos, copaiba balsam,
Coffee `` seed, leaf '', kobushi or magnolia (spicy pepper), burdock (burdock, burdock), kobodzu, sesame (sesame), sesame nohagusa (genus), gojishiza or binanakuzura or matsubusa, wheat (wheat). , Rice or rice bran "Aka bran, Shiranuka", rice oil, cola acluminata "seed", cola vera "seed", colony lya, fenugreek "fruit",
Colombo, Conzulango, kelp, konjak, konfuri (final grass), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or sycamore vine or chinensis (weapon), sakura (oshimazakura, yamazakura, oiyamazakura,
Ed Higashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran, sasanka, sadiomodaka (sawamai, sakurai), sasaki Sugar cane, sugar beet, rapeseed jujube (Natsumejin), saffron
Western safflower), sapodilla, sapote mario, pomelo "fruit", savon soup, salmon berry "fruit", sala chinensis (marsh), salan citrus (sand indigo pin), salvia
(Sage), Sawagikyo (Yamakage), Sawagurumi (Salmon Walnut), Sankaku Cactus, Sangre Degrad (Croton), Sankuyokuso, Sanshichinengin (37 ginseng), Sanshuyu (Yamatake mushrooms), Sansho (sansho), Sandscon (wild bean root), Shea (carite), Cyanoki “fruit”, Shiitake mushroom (Shiitake mushroom), Zion (Shien), Shikakumame, Dixalis,
Shikunshi (Koshikuniko), Perilla or Aojiso or Chirimendiso or Catamendiso (Shiso leaf, Shisoko), Rosewood, linden, Shina honoki, Shinarengyo (Long-termed), Shimeji (Hinjimeji, Shakashimeji, Hatakeshimeji, Bushimejita, Bushimejita, Bushimejita, Bushimejita, Bushimejita, Beechashita ), Magnolia (spicy), spirea, potato, peony
(Peony root), Shajin (Shasan), Jasmine (Matsuryuka), Janohige (Mugimon winter), Juroku cowpea, Syringa paniculata, Shukshamitsu (Sandhi, Crushed sand), Juzdama, Shiro "fruits", Shunran, Dauca palm ,Ginger
(Ginger), hydrangea (tsuneyama), shobu (iris,
Iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-breasted butterfly "seed", white clover (clover), white azuki (chicken bone grass), white squirrel (smell iris), white clover "flowers", white lupine, Shirominanten (Nami Tenmi), Shinkona Sakushibura, Jinchoge (Mizuka, Zuihika, Shichohana), Cinnamon, Cinnamomum cassia (cinnamon), Watermelon (watermelon),
Honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swimberry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste, horse toothbrush). ), Plum "fruit", Surugaran (Oran), Pinus sylvestris "cone", Japanese larch, European Ivy, gulmi, hawthorn, hazelnut, dandelion, horse chestnut (marronii), pear "fruit", natsukiyu Kisou, Sambucus nigra (Elder), Nezu (Juniper, Juniper), Achillea millefolium (Milfoil), Rose of rose, Steller's fowl,
Mistletoe, European Mint or Western Mint, Horseradish, Sekisho (Ishikon), Ginkgo
(Sakura Sekkoku, Kouki Sekkoku, Oobanashi Sekkoku, Okinawa Sekkoku, Hong Sekkoku, Kocho Sekokoku, Shikaku Sekkoku, Kibanano Sekokoku) (Dendrobium, Ishibana), Cedron (Boushuubokku), Zeniaoi,
Hiroha Senega, Senega, Celery, Celery, Senkyu (River Kyu), Senshinren (Shinren), Sendan, Sennin Cactus, Senna "Fruits, Leaves", Senninsou (Taiso),
Senburi (this drug), Senboku, Souka (grass fruit), Elephants, soybean rootweed, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, currant fruit), takasago rorihigotai (south indigo) (Stab), Takasaburo (Lotus lotus), Takatodai (Ojaku), Takawarabi
(Inui), dark sweet cherry "fruit", hollyhock, pearl oyster (thyme, Hyorika), tachidokoro
(Haikai), Tachiyanagi, Tamarind "seed", Onion, Tamushiba (spicy), Taranoki "fruit, leaves, root bark",
Dahlia (Tenjikubotan), Taruwi, Tankirimame, Tanchiuchiwa, Tanjin (Tanjin), Dandelion (Kankei English) or Shirobana Dandelion or Moukodandelion, Danmal, Cherry "fruit", Chigaya "fruit, root, bud", Chixet carrot. ), Chicory, Chanka piedra (Kidachikomisou), tulip, choconostay, darts thistle (artichoke), ginseng (daikoku), ginseng (garden), ginseng (spiny leaves), choreimaitake (boiled boar), Chorogi, gypsophila, Tsukusakaneran, Tsukuritake (mushroom),
Tulip grass, camellia, camellia, clover, clover (lacquer grass), duckweed (duck grass), adzuki bean (red adzuki bean), periwinkle, periwinkle, tsuruna (apricot), ginseng (four leaf ginseng), ginseng, tsuwabuki, kowabuki, tsuwabuki. , Walnuts, duberry "fruits", agar, tencha (green tea),
Tendai eu yak (crow), ginger (winter gourd), horned vine, capsicum (pepper), Japanese tuki (homecoming), Japanese ginseng
(Marigold), Gleditsia sinensis, Touna Bena (river cut),
Maize or corn hair (nanban hair), squirrel (sadako), gentian or gentian
(Dragon gall), horse mackerel (tree bandit), dokudami (10 medicines), turmeric (root root), Toshishi or medaka oshi or Nenashikazura, Eucommia (Musaka "bark, leaf, root"), ash (Hata peel), tomato,
Tragant, Triacanthus `` seed '', Eustoma grandiflorum, Tormentilla, Delonoki, Troloa mallow, Tonka bean, Nigeria berry `` fruit '', Chinese yam or Yamano yam (mountain drug), Naguikada (Butcher bloom), Naginata Koju, Nazuna, rapeseed, Nahameta or Natae Sword bean), Natsumikan, jujube (Oju), Naniwaibara (Kinzako), Navena (interrupted), Nameko, peanut (peanut),
Nanten (Nami Tenmi), Nanban Karamushi (Cara hemp), Nioisumire, Nigaki (Bitterwood), Garland mugwort (Bitterwood), Nikkuzuku, Kay or Nikkei or Ceylon Nikkei or Yabu Nikkei
(Keikin) or Keishi (Keishi), Gourmet, Leek (Nishi), Elderberry (Grinding (Fruit, Flower, Stem, Leaf)), Garlic (Garden), Nurude (Pentatus), Leek, Naemoki or Nebu or Nebi Or Nemuriki or Jogokubana (Negro), thistle
(Oyagi), Noibaru (Fruit), Nozomi Kazura (Ryosaku), Nogetou, Yarrow, Nodake (Maehu), Novara, Peach, Pineapple `` fruit '', Hibiscus (Busouge, Furinbusouge, Roselle), Hyelindo,
Hachiwa, Pau Dose, Hakamaurabosi (bone fracture supplement), Hakukayumato, Hakusan Chidori, Hakusen (tinea versicolor), Hakulberry `` fruit '', Hakobe (prosperous), Hazel (Haruko),
Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus root), parsley (netherlands jelly), hadakamugi, batata, bee or madake (boiled bamboo), patchouli, peppermint (light load, light load leaf), peppermint, pearl barley ( Yokuinin), Hananasuge (Chinese mother), Banana, Hanamint, Hanabishi (Shirushi, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed
(Mouse koji), pahalobobo, hub `` whole grass, stem, leaves '', paprika, sea peony, hagumou or mitsuba hamago (vine vine), hamasuge (kazushi), hamabishi (shitsuriko), hamanasu (maikai flower), Hamabofu (Hama Windbreak), Hamamelis,
Palm, rose (rose), balata, balata gum, agaric (aratake, white-bellied agaric, Uskimorinosaka), Haran, Paliurus (Hamamatsume), Parietaria, Harkanlan, Balsamina (Tsurureishi,
(Nigauri), Harunire (black leather, white leather, yellow leaf), Barbasco, Harlindou, Handaikai (Yu Taikai), Panoki,
Hyogi (dried dry), carrot (carrot), pecan nuts, hemlock (stone garlic, vine pearl scent), Higulmadaria, higotai, Hishi (hishimi), pistachio, beet, honeywort (stone reed), hydrangea, daisies (daisy),
Hinako no Kochi (cow knee), Hydrangea cypress, Japanese cypress, Hiba, castor, sunflower, green pepper, Himeuzu (Aoi), Himematsu (scented), Himematsutake (Kawariharatake, Hiromatsutake), Himemu orchid, Pimentha "Fruit", Biyaku, Biyaku Hiyu "Fruits", Chickpeas, Flounder, Broadbill, Oyster Flower (Bald Ears), Loquat "Fruits, Leaves, Stems", Areca (Large skin, calyx), Pu'er tea (Fu-cha), Futokazura (South rattan) , Butterbur, butterbur dandelion (submarine winter flower, subterranean winter leaf), wisteria mackerel (orchid), wisteria beans
(Foliage), Fujimaki (Chrysanthemum japonicum, Fusarium japonica), grape "fruit, fruit skin, seeds, leaves", beech, Fuyusuminatsutaketake (Coleoptera), Brazilian licorice, Brazilian carrot,
Brazilian palm, Brazilian elephant palm, black currant "fruit", blackberry, blanchen, plum "fruit", fulceraria, prune, floral blanka, blond psyllium, bundou (mung bean), hazelnut, loofah, hetkaran, safflower (safflower) , Henneken, Belladonna, Berry "fruit", Persea, Perbianberg, Pereschia grandifolia, Benchisou or Duckweed (Keiten), Boysenberry "fruit", Broomweed or Narcissus or Narda or Hahagiki Kokia
(Jikinko), Hosairan, Hosenka (Hosen, Acute child,
Bone grass), Pouteria sapota, Pouteria lucuma,
Spinach, bow hu (windbreak), spinach, physalis
(Torone), honoki (Japanese takuboku, magnolia), bokeh (wooden melon), hollyhock Abragiku (bittersweet), hollyhock grass, hollyhock moss
(Sosou), Rhododendron japonicum (Keiten Sanchi), Rhododendron japonicum, Bodaiju (Bodhi tree), Button (peony `` flower, leaf,
Stem, bark "), button pie (peony skin), hop, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Sekiseki Suzu, Suzuyama Ishihasu) , Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Mako), Maca, Macadamia nuts, Margaret (Mokshungiku), Makuri (Seagrass), Magwa (Mulberry bark "bark, leaf"), Magnolia・ Sprengheri, Masarunzuba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Matsukasa), Matsukasa, pine "leaf, bark, root", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanajaca), Marvanojazin (Ginseng), Mulberry "fruit", quince, Malein (Bilroadmou) Zuica), mango, mangosteen, mansagna (Andes chamomile), manshugurumi, mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), purple corn, purple fuji (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (beneficial herbs), barley, melaleuca, melissa, meliloth,
Melon "fruit", Mokoyomogi, Moso bamboo, Mokugirin, Mojé (pepper), Mokkou (wood incense), Maple, Peach (peaches "leaves, seeds, flowers, fruits"), coconut, morello cherry "fruits", Moroheiya (Burlap), yakawamurasakiimo, yakchi (maschi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or himeyashabushi or okiyashabushi `` fruit,
`` Pericarp, Kaho '', willow, yamde (octagonal metal plate), mistletoe (willow parasite), willow (kawayanagi, weeping willow, weeping willow, red willow, willow willow, willow dog,
(Willow, cory willow, unryan willow, willow willow, palm, willow willow, willow willow, willow willow, fox willow, doronoki), willow tree `` leaf,
"Stem", Pepper, Yabkoji (purple gold bull), Yab tobacco
(Tsuru, Tenmeisei), pokeweed (Shokuryoku), yamahanoki (Yamaharu), bayberry (Yangume), yamamogimo, eucalyptus, yukinoshita (tiger ear grass), yucca or flavifolia, yuzu "fruit", lily, yellow dragonfly , Mugwort (mushroom leaf), ligan (thunder circle), lime "fruit", rye, swingle "fruit",
Raspberry `` leaves, fruits '', latania (clameria), lacquer or shallot (caucasian), lavender, longan (dragon eye meat), agave (Aono agave,
Fukurin agave), ryokcha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, lubas or Suavisimus (hushun), Luritama thistle (Vladivorogogo tai, Xinjiang indigo head), litchi (lunch, leek branch), Lettuce,
Red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia
(Rensai), Astragalus, Rhizoma (Rumei), Roukon, Locon (Reed, Rhizome), Loganberry "fruit", Rosemary (mannenrow), Rosehip (Novara), Wasabi, Cottonweed (Mimugi flower), Waremokou (Jiju) and the like.

As seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (Usubaaonori, Sujiaoonori, Hiraaoonori, Bouaoonori, Hosoedaonori), Ananaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (Suisenzinori: Suisenzinori, Aza genus, Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa genus: Ichimegasa, Keyari genus: Keyari, Umibosu genus: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Ushikenori, Funorinoushike, genus Amanori: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a genetically modified product or a cell fusion product,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried product, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microorganism culture metabolites Yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, fungi or actinomycete metabolites, mold or actinomycete extract, natto metabolites, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamarisu, yamagwa, extended life grass, bellflower, horsetail, succulent, yellow-dried, hemp dry, hemp. Senkyu, dokkatsu, psycho, bow hu, hama boufu, sardine, peony skin, peony, genosho, kakkon, licorice, quintuplet, aloe, shouma, safflower, green tea, black tea, assen drug) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Rosemary, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini sasanishiki extract, natto metabolite, natto extract, loofah water, birch (white birch) or sap of red pine

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, hypericum, clara, mulberry leaf, cinnamon, genus ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair Treatment Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or its derivative, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, castorium and ambergris, anise essential oils, angelica essential oils, ylang-ylang essential oils, iris essential oils, fennel essential oils, orange essential oils, cananga essential oils, caraway essential oils, cardamom essential oils, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, endu dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetics
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory / anti-allergic agents, wound healing agents, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, etc. can be mentioned. By using them together, the effect of the present invention or other cosmetics It is expected that additive or synergistic improvement of the social effect will be achieved.

The method for adding the hyaluronidase activity inhibitor of the present invention to the cosmetic composition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability. good.

[0073]

EXAMPLES Hereinafter, production examples, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Production Example 1) 100 g of various dried plants of cowberry and tarayo were extracted by warming with purified water (about 80 ° C.) for about 5 hours, filtered, and then extracted (dry solid content: about 0.1 to 2.5%). About
You get 1.0kg.

(Production Example 2) 100 g of various dried plants of cowberry and tarayo were dipped in a 50% ethanol solution and allowed to stand at room temperature for 5 hours.
After extracting day and night, filter and extract (dry solids: about 0.1
~ 2.5%) about 1.0 kg.

(Production Example 3) 100 g of various dried plants of cowberry and tarajo were mixed with 70% ethanol solution or 70% 1,3-butylene glycol solution or 60% propylene glycol solution,
Alternatively, it is immersed in purified water (about 30 ° C.), extracted at room temperature for 5 days, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 3.0%).

(Test 1) Hyaluronidase activity inhibition test "Test method and evaluation method" To 0.1 mL of a sample, 0.05 mL of a hyaluronidase solution (final concentration 0.4 mg / mL) was added, and the mixture was allowed to stand at 37 ° C for 2 hours.
After standing for 0 minutes, the Compound 48/80 solution (final concentration 0.1 mg
/ ML) and leave it at 37 ° C for 20 minutes, then add 0.25mL of hyaluronic acid solution (final concentration 0.4mg / mL),
It was left for 0 minutes. Next, 0.4N sodium hydroxide solution 0.1mL was added to stop the reaction, and then 0.8M potassium borate solution 0.1m was added.
L was added and heated in boiling water for 3 minutes. After cooling to room temperature, 1
After adding 3 mL of a% p-dimethylaminobenzaldehyde acetic acid solution and allowing it to stand at 37 ° C. for 20 minutes, the absorbance at 585 nm was measured. As a control, a blind test in which the enzyme was replaced with purified water was provided as a solvent of the sample, and the hyaluronidase activity inhibition rate was calculated from the following formula <Equation 1> from the difference in absorbance between the sample and the blind test.
The results are shown in Fig. 1. a. Samples The samples of the hyaluronidase activity inhibition test were various plant extracts (solid content concentration: 0.5) obtained in Production Example 2 of the present invention.
%) And used for the test.

<Equation 1> Hyaluronidase activity inhibition rate (%) = 100
-(Sample absorbance of sample-blind absorbance of sample) / (specimen absorbance of control-blind absorbance of control) x 100

(Test Results) As shown in FIG. 1, it was confirmed that the various plant extracts of cowberry and tarajo of the present invention had an effect of significantly inhibiting hyaluronidase activity.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid content concentration was about 0.5%. It was applied to the skin of Japanese white rabbits whose backs were shaved (female, 3 animals per group, weight 2.3 kg). Evaluation was carried out 24, 48, and 72 hours after application using erythema and edema as indices based on the Draize criterion. As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 3) Safety test (2) Cumulative skin irritation test Similarly, various plant extracts obtained in Production Examples 1 to 3 were purified water to a dry solid concentration of about 0.5%. Prepared and shaved back Hartley guinea pigs (female, 1 group 3)
0.5 mL for once a day, 5 times a week on the skin of an animal (body weight: around 320 g)
/ Animal was applied. Application was carried out for 2 weeks and shaving was carried out on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. The result is 2 in all animals
No erythema or edema was observed over the week, and it was judged that there was no problem with cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test Various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%, and 16 mL / mouse / kg amount,
Before the test, it was orally administered to ddy mice (male and female, 5 mice in each group, 5 weeks old) that had been fasted for 4 hours, and the expression and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined to be a safe substance.

(Prescription example) Hyaluronidase activity inhibitor,
Manufacture of Cosmetic Composition The formulation examples are shown below according to the above-mentioned evaluation results. Each formulation example may be one produced by a conventional method in the production of each product, and only the blending amount is shown. Further, the present invention is not limited to these.

[0084] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Cowberry extract of Production Example 2       B: Tarayou extract of Production Example 2       * Any one of A to B extract 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0085] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Cowberry leaf or stem 70% ethanol extract 3.0    14. Tarayo leaf or stem 70% ethanol extract 3.0    15. Pork placenta water extract 1.0    16. Preservative (paraoxybenzoate) Suitable amount    17. Residue to make purified water 100

[0086] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Hot water extract of cowberry flowers or spikes 3.0     6. Tarayo bark hot water extract 3.0     7. Grapefruit fruit or leaf hot water extract 3.0     8. Tochu leaf hot water extract 3.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Preservative (benzalkonium chloride) Suitable amount    15. Perfume (oncoming water) Appropriate amount    16. Residue to make purified water 100

[0087] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Cowberry rhizome 30% ethanol extract 3.0     6. Yuzu fruit 30% ethanol extract 1.0     7. Chickweed whole plant 30% ethanol extract 1.0     8. Grape stem or leaf 30% ethanol extract 1.0     9. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0    10. Kiwi fruit 50% ethanol extract 1.0    11. White birch sap 1.0    12. Antibacterial / antiseptic (lactoferrin solution)    13. Perfume (Western light water) Suitable amount    14. Purified water 100 residue

[0088] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4. Whole cowberry 50% 1,3-butylene glycol extract 3.0     5. Tarayou whole plant 50% 1,3-butylene glycol extract 3.0     6. Whole plant 50% 1,3-butylene glycol extract 2.0     7. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     8. Gentian whole plant 50% ethanol extract 2.0     9. Sage whole plant 50% ethanol extract 2.0    10. Yeast 50% 1,3-butylene glycol extract 1.0    11. Allantoin 0.2    12. Astringent (zinc sulfocarbonate) 0.2    13. Antibacterial and antiseptic (thiamin lauryl sulfate)    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0089] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Tarayo fruit 50% propylene glycol extract 2.0     6. Red radish rhizome or root bark 50% propylene glycol extract 2.0     7. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0     8. Whole assembly 50% 1,3-butylene glycol extract 2.0     9. Sage whole plant 50% ethanol extract 1.0    10. Fucoidan derived from seaweed Okinawa mozuku 0.2    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (lemon water) Suitable amount    15. Residue to make purified water 100

[0090] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Cowberry fruit 50% propylene glycol extract 2.0     8. Astragalus flower 50% propylene glycol extract 2.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Pig placenta enzymatic degradation solution 1.0    13. Camphor 0.2    14. Phenol 0.03    15. Preservative (photosensitive element 201 & 401)    16. Perfume (bodhi water) Suitable amount    17. Residue to make purified water 100

[0091] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Glycerin extract with 50% bilberries or rhizome 1.0     6. Tarayou rhizome 50% glycerin extract 1.0     7. Raspberry fruit 50% diglycerin extract 1.0     8. Choji Bud 50% Diglycerin Extract 1.0     9. Unshu mandarin orange peel 50% 1,3-butylene glycol extract 1.0    10. Green tea leaf hot water extract 1.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume (Rose water) Appropriate amount    13. Residue to make purified water 100

[0092] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Cowberry flower or spike 50% glycerin extract 2.0     8. Safflower whole plant 50% ethanol extract 2.0     9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    10. Royal Jelly 50% Ethanol Extract 1.0    11. Trehalose solution 1.0    12. Preservative (paraoxybenzoate) Suitable amount    13. Perfume (Chamomile water) Suitable amount    14. Purified water 100 residue

[0093] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Cowberry seed extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Panax ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Preservative (acrinol) 0.1    17. Fragrance (sage water) appropriate amount    18. Residue to make purified water 100

[0094] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Cowberry leaf or stem hot water extract 3.0    11. Dodami leaf hot water extract 3.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Preservative (paraben) proper amount    18. Perfume (clove water) appropriate amount    19. Residue to make purified water 100

[0095] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Cowberry leaf or stem 50% glycerin extract 1.0     8. Tarayou rhizome 50% glycerin extract 1.0     9. Kawara Artemisia leaf 20% 1,3-butylene glycol extract 2.0    10. Rosehip fruit 30% ethanol extract 1.0    11. Kakkon hot water extract 2.0    12. Glycyrrhizic acid 1.0    13. Preservative (salicylic acid) 0.1    14. Perfume (sage water) appropriate amount    15. Residue to make purified water 100

[0096] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Cowberry extract of Production Example 2       B: Tarayou extract of Production Example 2       * Any one of A to B extract 5.0    10. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    11. Glycyrrhetinic acid 0.5    12. Preservative (salicylic acid) 0.1    13. Perfume (Mugwort water) Suitable amount    14. Purified water 100 residue

[0097] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Tarayou seed 70% 1,3-butylene glycol extract 1.0     5. Oolong tea leaf 70% 1,3-butylene glycol extract 1.0     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7. Seaweed 70% 1,3-butylene glycol extract 0.5     8. Meliroth flower or leaf 70% 1,3-butylene glycol extract 0.5     9. Armature leaf or stem 70% 1,3-butylene glycol extract 0.5    10. Soybean seed fermented soybeans 0.5    11. Polyethylene powder 0.5    12. Hydroxypropyl chitosan solution 0.5    13. Amino acids (arginine, glycine, glutamine, etc.) 0.5    14. Monoammonium glycyrrhizinate 0.1    15. Preservative (undecylenic acid, phenol) Suitable amount    16. pH adjuster    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0098] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Cowberry fruit or peel 50% dipropylene glycol extract 0.5    14. Tarayou fruit or pericarp 50% dipropylene glycol extract 0.5    15. Cornflower leaf 50% propylene glycol extract 0.5    16.Kakkon 50% propylene glycol extract 0.5    17. Yuzu fruit 50% dipropylene glycol extract 0.5    18. Preservative (benzyl paraoxybenzoate) Suitable amount    19. Perfume (apple water) Appropriate amount    20. Residue of purified water 100

[0099] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 25.0     5. Cowberry leaf or stem 30% 1,3-butylene glycol extract 1.0     6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0     7. Burdock root hot water extract 0.5     8. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     9. Mallow flower or leaf 50% propyl alcohol extract 0.5    10. Allium 50% 1,3-butylene glycol extract 0.5    11. Incense fruit 30% butanol extract 0.2    12. Antioxidant (Butyl hydroxytoluene) Suitable amount    13. Fragrance (cornflower water) Suitable amount

[0100] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Tarayou leaf or stem hot water extract dry powder 0.2    16. Dokudami leaf hot water extract dry powder 0.2    17. Wenzhou tangerine peel or fruit hot water extract dry powder 0.2    18. Yukinoshita whole grass hot water extract dry powder 0.2    19. Preservative (phenoxyethanol) 0.1    20. Perfume (Rose water) Suitable amount    21. Residue to make purified water 100

[0101] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Cowberry rhizome 20% 2,3-butylene glycol extract 2.0     7. Hamamelis bark hot water extract 2.0     8. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0     9. Toki root 30% 1,4-butylene glycol extract 1.0    10. Hydroxypropyl chitosan solution 1.0    11. Mucopolysaccharide solution 1.0    12. Dipotassium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (photosensitive element 101)    14. pH adjusting agent    15. Perfume (sandalwood water)    16. Residue to make purified water 100

[0102] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Cowberry leaf or stem 50% 1,2-pentanediol extract 1.0     6. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     7. Scented flower 50% 1,3-butylene glycol extract 1.0     8. Yellow rhizome 50% 1,3-butylene glycol extract 1.0     9. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    10. Soybean seed fermented soybeans 0.5    11.Hydroxyethyl chitosan solution 0.5    12. Trehalose solution 0.5    13. Hydrolyzed silk solution 0.5    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (grape water) Suitable amount    16. Residue to make purified water 100

[0103] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Tarayou leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Western Bodhi bark or fruit 50% 1,4-butylene glycol extract 1.0     8. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0     9. Olive leaf 50% 1,2-butylene glycol extract 1.0    10. Loquat leaf 50% ethanol extract 1.0    11. Trehalose solution 1.0    12. Hydrolyzed keratin solution 1.0    13. Antibacterial / antiseptic (benzalkonium chloride)    14. Perfume (Chamomile water) Suitable amount    15. Residue to make purified water 100

[0104] (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Cowberry leaf 50% 1,3-butylene glycol extract 1.0     6. Tara-yo leaf 50% 1,3-butylene glycol extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0105] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6. Tarayo bark 50% 1,3-butylene glycol extract 1.0     7. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     8. Panax ginseng root hot water extract 1.0     9. Lemon fruit 50% 1,3-butylene glycol extract 0.5    10. Apple fruit 30% ethanol extract 1.0    11. White birch sap 1.0    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0106] (Formulation Example 22) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Cowberry extract of Production Example 1       B: Tarayou extract of Production Example 1       * Any one of A to B extract 5.0     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or bark hot water extract 1.0     9. Preservative (phenoxyethanol) 0.1    10. Perfume (Chamomile water) Suitable amount    11. Residue to make purified water 100

[0107] (Prescription example 24) Hair artic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6. Cowberry leaf hot water extract 2.0     7. Lavender flowers or spikes hot water extract 1.0     8. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0     9. Scutellariae rhizome or root bark 50% ethanol extract 1.0    10. Pleurotus rhizome or root bark 50% ethanol extract 1.0    11. Soybean seed hot water extract 1.0    12. Carboxymethyl chitin solution 1.0    13. Vitamin E derivative 0.5    14. Antibacterial and antiseptic (paraben) 0.1    15. Perfume (sage water) appropriate amount    16. Residue to make purified water 100

[0108] (Prescription example 25) Hair growth and hair nourishing agent Mass%     1.Ethanol 60.0     2. Cowberry leaf or stem 50% glycerin extract 2.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Pig hematin solution 0.5    10. Pig mucin solution 0.5    11. Amino acids (arginine, glycine, glutamine, etc.) 0.5    12. Antibacterial and antiseptic (paraben) 0.1    13. Fragrance (rosemary water) Suitable amount    14. Purified water 100 residue

[0109] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. Tarayou leaf or stem 50% glycerin extract 1.0     3. Whole assembly 60% ethanol extract 1.0     4. Peony rhizome or root bark 60% ethanol extract 1.0     5. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     6. Soybean seed fermented soybeans 1.0     7. Cantharis tincture 0.5     8. Pantothenic acid derivative 0.2     9.β-glycyrrhetinic acid 0.2    10. Resorcin 0.2    11. Salicylic acid 0.2    12. Hydroxyethyl chitosan solution 0.2    13. Elastin hydrolyzate 0.2    14. Antibacterial and antiseptic (paraben) 0.1    15. Perfume (lavender water) Suitable amount    16. Residue to make purified water 100

[0110] (Prescription example 27) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4. Cowberry leaf hot water extract dry powder 4.0     5. Eucalyptus hot water extract dry powder 3.0     6. Jujuba whole plant hot water extract dry powder 3.0     7. Dye (Gunjo green) Appropriate amount

[0111] (Formulation example 28) Granule bath agent                                                               mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Dried powder of hot water extract of tarayo leaf 3.0     5. Sambucus nigra flower or berries hot water extract dry powder 1.0     6. Kawamura Artemisia leaf or stem hot water extract dry powder 1.0     7. Wenzhou mandarin orange peel or fruit 50% ethanol extract dry powder 1.0     8. Peach leaf 70% ethanol extract dry powder 1.0     9. Iris leaf or root 70% ethanol extract dry powder 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Formulation Example 29) Coating protective agent A gauze or liniment cloth is impregnated with a formulation liquid in which an appropriate amount of cowberry fruit or leaf hot water extract and tarayou fruit or leaf hot water extract, antibiotics, anti-inflammatory agents and the like are mixed. And attach it to the wound. Alternatively, the hot water extract of cowberry fruits or leaves and the hot water extract of tarayou fruits or leaves may be directly sprayed locally and covered with gauze or the like.

[0113] (Prescription example 30) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Cowberry fruit or leaf hot water extract dry powder 0.1     7. Tarayou fruit or leaf hot water extract dry powder 0.1     8. Green tea leaf hot water extract dry powder 0.1     9. Dye (Gunzhou Green) Appropriate amount    10. Residue to make purified water 100

[0114] (Prescription example 31) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Cowberry fruit or leaf hot water extract dry powder 1.5     6. Tarayo fruit or leaf hot water extract dry powder 1.5     7. Rubus pericarp or fruit hot water extract dry powder 2.0     8. Residue to make purified water 100

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test is for healthy adult women 25 ~
30 people each 50 years old will be panelists, and there will be 2 daily mornings and evenings.
After washing the face and washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Tables 1 and 2, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of skin tension and luster improvement] Effective: Increased skin tension and gloss. Slightly effective: Skin tension and luster slightly increased. Ineffective: No change from before use.

[0117]

[Effect of Wrinkle / Talmi Improvement of Skin] Effective: Wrinkle Talumi is less noticeable. Slightly effective: Wrinkle Talmi is slightly less noticeable. Ineffective: No change from before use.

[0119]

(Test Results) As shown in Tables 1 and 2, emulsions containing various plant extracts of cowberry and tarajo of the present invention were
It was confirmed that the skin was given firmness and gloss, and that wrinkles and tarmi of the skin were also reduced.

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test was conducted by 30 people aged 30 to 50 years old who suffer from eczema, itchiness, and rough skin, and apply the appropriate amount of the emulsion of Prescription Example 1 to the face for 3 months after washing twice daily in the morning and at night. It was done by doing. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Table 3 and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

"Eczema, rough skin improving effect" Effective: Eczema, itchiness, and rough skin were improved. Slightly effective: Eczema, itchiness and rough skin were slightly improved. Ineffective: No change from before use.

[0123]

(Test Results) As shown in Table 3, it was confirmed that the emulsion containing various plant extracts of cowberry and tarajo of the present invention improves eczema, itchiness and rough skin.

[0125]

EFFECT OF THE INVENTION A hyaluronidase activity inhibitor or cosmetic composition containing one or more plant extracts selected from cowberry and tarayo of the present invention can be confirmed to have a hyaluronidase activity inhibitory effect, and also to the skin. On the other hand, imparting tension and luster, improving wrinkles and tarmi, and further,
Inflammatory skin diseases (eg, eczema, itching, rough skin, etc.) can also be ameliorated. Therefore, it is effective for prevention of skin aging or skin inflammation. The present invention can also be used for other general foods and drinks.

[Brief description of drawings]

FIG. 1 is a graph showing the hyaluronidase activity inhibition rate of various plant extracts of cowberry and tarajo of the present invention.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 U 7/02 7/02 Z 7/06 7/06 7/075 7 / 075 7/08 7/08 7/11 7/11 7/26 7/26 7/42 7/42 7/48 7/48 7/50 7/50 A61P 17/00 A61P 17/00 17/04 17 / 04 17/14 17/14 29/00 29/00 43/00 111 43/00 111 F term (reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC072 AC102 AC112 AC122 AC132 AC172 AC182 AC242 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AC682 AC692 AC782 AC792 AC852 AC862 AC902 AD022 AD042 AD092 AD112 AD212 AD272 AD322 AD412 AD442 AD512 AD532 AD552 AD642 AD662 CC01 CC04 CC05 CC07 CC12 CC19 CC23 CC25 CC33 CC37 CC12 DD39 CC41 DD05 EE17 EE22 EE34 4C088 AB12 AB44 AC01 AC03 AC04 AC05 A C06 AC11 AC12 BA08 BA09 BA10 CA03 CA04 CA05 CA06 CA07 CA08 MA63 NA14 ZA89 ZA92 ZB22 ZC20

Claims (2)

[Claims] 1. A hyaluronidase activity inhibitor comprising one or more plant extracts selected from cowberry and tarayo. 2. A cosmetic composition comprising the hyaluronidase activity inhibitor according to claim 1.