JP2003192530A - Wild silkworm silk fiber - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe cosmetic composition. <P>SOLUTION: This cosmetic composition comprises silk fibers produced from wild silkworms and any one or more kinds of bleaching agents, antioxidants, antimicrobial agents and humectants. Thereby, the resultant cosmetic composition has excellent bleaching, antioxidant, antimicrobial and humectant effects and further is capable of significantly ameliorating dry skin, imparting gloss and firmness to the skin, ameliorating dermal stains and ephelides and bleaching and reducing the skin color. As a result, the composition is effective for preventing skin aging and can be applied to all forms of preparations (medicines, quasi-drugs or cosmetics). <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to application to a cosmetic composition containing silk fiber produced by wild silkworm and any one or more of a whitening agent, an antioxidant, an antibacterial agent and a moisturizer. Is.

[0002]

2. Description of the Related Art Traditionally, the application of domestic silkworm silk fiber to cosmetics has been carried out for a long time. For example, the domestic silkworm silk fiber itself is applied to soap (Japanese Patent Publication No. 25-3733),
What is applied to cosmetics by processing silkworm silk fibers into a solution or powder (Japanese Patent Publication No. 26-4947) (Japanese Patent Publication No. 27-299) (Japanese Patent Publication No. 40-24920) (Japanese Patent Publication No. 54-138131) 55-2712
0) (JP-A-55-66929) (JP-A-57-4909) (JP-A-57-4909)
910) (JP-A-57-3827) (JP-A-58-15905) (JP-A-60-60)
-4114) (JP-A-59-65008) (JP-A-62-36308).

However, these are domestic silkworms.
The silk fiber produced by "Bombyx mori Linne (Bombycidae)" is used. Before the silk fiber is scoured, it is called "raw silk", and its composition is called "fibroin", which is the main protein of the fiber, and It is formed of a protein that wraps around fibroin called "sericin". Generally, fibroin protein is called silk fiber, which is pulverized into fine powder or hydrolyzed to form a solution and applied to cosmetics. On the other hand, sericin protein is removed at the stage of scouring raw silk, but recently it has been purified and applied to cosmetics. The fine powder of fibroin protein is known as a functional material of cosmetics, a texture improving agent such as foundation, and a moisturizing agent that makes good use of hygroscopicity or desorption of protein.
No other functionality is currently reported.

On the other hand, with respect to wild silkworms, various kinds of silkworms are known, for example, Saku silkworm "Antheraea perny".
i ”, Eri silkworm“ Samia cynthia ricini ”, Tasar silkworm“ A ”
nthraea mylitta ”, Anafe“ Anaphe reteculata ”,
Moth silkworm “Antheraea assama”, Cricula “Cricula tr
"ifenestrata", "Atheraea yamamai", etc. can be mentioned.

The silk fiber produced from the silkworm has a dense structure, but when observing the silk fiber produced from the silkworm with a scanning electron microscope, no pores are observed in the cross section, and the silk fiber obtained from the above-mentioned silkworm is not observed. The silk fibers produced have very small pores, making use of this structural feature.
Application of natural materials that block ultraviolet (UV) rays is known (Japanese Patent Laid-Open No. 11-181399).

[0006]

Therefore, the present inventors have paid attention to the porosity which is a characteristic of silk fiber produced from wild silkworms, and further, effective cosmeceutants by using it in combination with various functional ingredients. The application was examined as a subject.

[0007]

In view of these circumstances, the present inventors have found that silk fibers produced from wild silkworm, a whitening agent,
It was found that a cosmetic composition containing at least one of an antioxidant, an antibacterial agent and a moisturizer has an extremely excellent whitening effect, antioxidant effect, antibacterial effect and moisturizing effect, and completed the present invention. Came to do.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The "silk fiber produced from wild silkworms" used in the present invention means the silkworm silk "Antheraea pern".
yi ”, Eri silkworm“ Samia cynthia ricini ”, Tasar silkworm“ Anthraea mylitta ”, Anafe“ Anaphe reteculat ”
a ”, Muga silkworm“ Antheraea assama ”, Cricula“ Cricu ”
A silk fiber (cocoon or cocoon thread) produced from "la trifenestrata", "Antheraea yamamai", etc. can be used.

The particle size of the "silk fiber produced from wild silkworms" used in the present invention is not particularly limited, but is usually 0.01.
It is possible to use fine particles having a particle size of up to 500 μm, preferably 0.1 to 50 μm. The silk fiber can be washed and colored before use. The means for atomizing the particles is not particularly limited, but means for physically crushing may be used.

The "whitening agent" used in the present invention includes benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxy). Sodium benzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc., paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, paraaminobenzoic acid) Glyceryl,
Amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamic acid)
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamic acid mono
-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanine Acid derivatives (urocanic acid, ethyl urocanate, etc.), vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivatives (hydroquinone benzyl ether, etc.), coumarin or its derivatives, amino acid system A compound, benzotriazole or a derivative thereof, tetrazole or a derivative thereof,
Imidazoline or its derivative, pyrimidine or its derivative, dioxane or its derivative, camphor or its derivative, furan or its derivative, pyrone or its derivative,
Nucleic acid or its derivative, allantoin or its derivative, nicotinic acid or its derivative, vitamin B6 or its derivative, vitamin E or its derivative, kojic acid or its derivative, umbelliferone, esculin, benzyl cinnamate,
Cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escarol, zinc oxide, zinc peroxide, talc, kaolin,
Placenta extract (human, cow, pig, horse), N-acetyltyrosine or its derivative, glutathione, hydrogen peroxide, silk extract, ellagic acid, lucinol, plant extract (Assenyaku, Amacha, Altea, Aloe, Aloe vera, Ginkgo) , Ages,
Enmeisou, Ogon, younger brother cut grass, Odorikosou, Kuzukon, chamomile, Karagua or Yamaguchi, licorice, bellflower, kina, kihada, clara, mulberry, yamushi, cinnamon, gennoshoko, quintuplets, black tea, shibahu, salvia, yamko, peony, sardine , Birch, honeysuckle, yarrow, senkyu,
Sequel, soybeans, cloves, toki, maedaoshi, dokudami, shishido or udo, white south or red south, coix,
It can be used such as lamella or honeywort, hamamelis, hamahofu, hops, safflower, peony, mao, matsuhod, mannenrow, melissa, hyacinth, yukinoshita, eucalyptus, mugwort or green wormwood, green tea, oleander, brown algae, red algae, etc. Also, one or more selected from these may be used in combination.

The "antioxidant" used in the present invention includes SOD (super oxidise dismutase), catalase, glutathione peroxidase, vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside). Etc.), stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, For gossypol, propolis, β-carotene, plant extract (sweet tea, ginkgo, ages, life-prolonging grass, younger brother cut grass, sesame, salvia, white birch, cloves, white south or red south heaven, hamamelis, mannenrow, melissa, green tea) etc. Rukoto can, may be used in combination one or more selected from these.

As the "antibacterial agent" used in the present invention, acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, Sodium chlorite, chloramine T, coconut powder, iodine compounds, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine Lauryl nitrate, phenol,
Cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH35
65, halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic Surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactants (Cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, Lilliant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, Clara extract, Propolis and the like can be used, and one or more selected from these can also be used in combination.

As the "moisturizer" used in the present invention, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its Salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, trehalose, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine, phenylalanine) , Tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylid , Arginine, ornithine,
Histidine and their sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids), fats and oils "avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange laffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil,
Safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk Oil, palm oil,
Palm kernel oil, wax, palm oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil) ", waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin) , Reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microchristan wax), Bacillus natto metabolites,
Natto extract, silk fiber extract, plant extract (red pine or red pine sap, aloe, aloe vera, kudzu root, chamomile, licorice, cucumber, rice or rice bran, shiitake mushroom, white birch or white birch sap,
Assembly, mulberry, Himematsutake, biwa leaf, loofah, peony,
For example, purple, mugwort, or mugwort) can be used, and one or more selected from these can also be used in combination.

"Whitening agent" and "antioxidant" used in the present invention
The "antibacterial agent" and "moisturizer" may be any of various commercially available components. The plant extract is not particularly specified, but various parts of each plant (whole grass,
Flower, head flower, spike, female spike, fruit spike, fruit, bud, pericarp, gland, stem, leaf, branch, branch, stem, bark, rhizome, tuber, root bark,
(Root, tuberous root, seed, umbrella or stalk, fruiting body, mycelium, sclerotium, etc.)
Squeezed as it is or after being crushed. Alternatively, as it is or after crushing, it may be extracted with a solvent, and the extraction solvent may be selected in consideration of the purpose of use of the product to be provided, the type, or the processing to be performed later, but usually,
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, only water may be used, or ethanol or the like that is easy to remove after extraction may be used and used alone or in any mixture with water, or, Exploited extract may be used. Furthermore, it can be used in a state where each solvent extract is combined. In addition, various plant extracts may be hydrolyzed and extracted by enzymatic decomposition, or hydrolyzed by acid or alkali.

The "silk fiber produced from wild silkworms" of the present invention can be contained in the cosmetic composition as it is, but the content thereof is not particularly limited, and the type of dosage form for the cosmetic composition, Slightly different depending on quality and expected degree of action, usually 0.001 mass% or more (hereinafter, expressed as%)
It is preferably 0.01 to 20%. In the case of bath agents,
It is recommended to consider the prescription so that it will be poured into 200 to 300 L of bath water so that the concentration is the same.

Similarly, each of the “whitening agent”, “antioxidant”, “antibacterial agent” and “moisturizing agent” of the present invention can be contained in the cosmetic composition, and the content thereof is not particularly specified. However, it is slightly different depending on the type of formulation of the cosmetic composition, quality, and expected degree of action, and is usually 0.001% or more, preferably 0.1 to 20%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

Regarding the method for adding to the cosmetic composition containing the silk fiber produced by the wild silkworm of the present invention, and one or more of a whitening agent, an antioxidant, an antibacterial agent and a moisturizing agent,
Although not particularly limited, a method of previously adsorbing various components (any one or more of a whitening agent, an antioxidant, an antibacterial agent, a moisturizer) to silk fiber produced by wild silkworm, and a cosmetic composition There is a method of mixing silk fiber produced by wild silkworms and various components (any one or more of a whitening agent, an antioxidant, an antibacterial agent, and a moisturizer) and then adding them. In the above method, the silkworm produces The silk fiber can be included in the formulation in powder form.

The cosmetic composition of the present invention may have any dosage form and form, and may be formulated in the form of capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets and the like. Can be used.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) For baths to be used Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, gargle, dishwasher, etc.

In addition to the above-mentioned essential components, the cosmetic composition of the present invention may optionally be selected and used in combination with the components and additives exemplified below, as needed, within a range that does not impair the effects of the present invention. Although not particularly specified, the content in the preparation is usually preferably 0.0001 to 50%.

(1) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(2) alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(3) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(4) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(5) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(6) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(7) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(8) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(9) Various additives derived from plant- or animal-based raw materials. These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol or isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Gojiri), Aotsutsurafuji (Kibo), Aotenma, Acacia, Redcurrant "fruit", Red clover, Red grape,
Red Amber (Logwood), Red Megawa (Akamekashi), Red Akane or Akane or Akane (Akane grass root), Red Astragalus or Giou (Ground yellow), Agi (Awe), Akikaramatsu, Akinire (Resilient skin), Aguay Guasu, Aguahe (Agaea) Great Blue Palm, Akebi (Kizu), Asa (Asahito),
Malva morning glory or morning glory (chocolate), hydrangea (hydrangea), ashitaba (tomorrow leaf), adzuki bean (red azuki bean), asunaro,
Acerola, Achira (Shouyoukanna), Anise, Abiu, Abiulana, Brassica, Abemaki "Fruit", Avocado, Ama, Amachazuru, Amadokoro (Tamatake), Amana
(Glorious), Amaranthus (Amaranthus, Hagatetow, Himogeito, Senninkoku, Sugimorigateu, Hosoaogateou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Aygastha lily or Baimo (shellfish), Alystroemeria, Alystroemeria, Lizardina alba ), Algarrobo (cabbage), Arnica, Alpinia or red sea bream (souk), Angelica, apricot or hon apricot (apricot kernel), Ansokkou (benzoic incense), yellow sapote, Igakouzorina (gebiliary head), Ikarisou or Yachimatikarisou (Inyoukaku), Igusa (Wicked grass), Knotweed (Kojo root), Yew (1st place), Strawberry, Fig (Fig. "Fruits and leaves"), Fig. (First time), Ichibi
(Fuyuko Aoi), Ichiyakuso (single medicinal herb), Itohimehagi (Denshi), Locust bean, Indactina (Taylexi), Inubiyu
(Honagainubiyu), rice `` seed, seed coat '', inondo `` seed '', mussel, nettle, ylang-ylang,
Sesame tobacco (Iwabaki), Iwahiba or Iwamatsu (Makiashi), common beans, oolong tea, fennel (incense), wheat
(Tibsanoki), Ukiagara (Sanryo), Uguisukagura `` fruit '', Himeikou, Turmeric (Utsukin), Duckweed (Umbrella), Usubasaishin or Keirinsaishin or Suzukasaishin (Spicy), Usbuniaoi, Usbenitachioi, Orchidaceae, Nepenthes (Summer hay), Udo or Shishido (Kanka, Karatsu, Karatsu), Unyadegato (Unkaria, Cat's Claw), Uba Tea, Ume (Ume "seed, pulp"), White-tailed Gourd, Water Urushi (Lepidoptera), Unshiukan (Chen-skin), Unboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibarenguiku), Enishida, Enokitake (Enokitake), Ebisugusa or Cassia tora (Keimeiko), Elcampre, Elderberry, "Fruit," Eryngii or Pre-Lotus Erinji, Enju (Souka), Window, Astragali or Astragalus membranaceus (Astragalus), Narukoyuri or key Small pink flowers Le Koyuri (Polygonati Rhizoma), Ouhisasanoyuki or Sasanoyuki, Coptis (Coptidis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil incense), giant Tsudzurafuji
(Self-defense), psyllium (carp, carp grass), plantain thistle
(Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Okera (White Agate), Obana Salsberg (Banaba), Obayashishabushi "Fruit", Oohoshigusa (Omegrass), Omiami, Oomimi, Oomimi (Barley), okka, okazeri (jade bedko), okra "fruit", oguruma (overturning), okururihigotai (washu peony,
(Indigo sting), ginseng or carrot (carrot),
Onamomi (Aomori), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasayayuri or Hakatayuri (Yuri), Onoeran, Ononis, Ohahyou (Ryakuyu), Ominaeshi (defeated soy sauce), Oyuko , Dutch mustard (watercress), Dutch jelly, Dutch biu, Dutch honeywort, olive "fruit, seed,
Leaf ", oregano, orange" fruit, pericarp ", kaisekiou (ripe ground yellow), cacao" fruit, pericarp, seed ", oyster (persimmon" leaf "), Kagizura (fishing hook), Kakidoshi or Kantriso (rensen) Grass), persimmon, hydrangea, cassia,
Casinoki (confection "fruit"), banyan tree (cassia, camellia), caskilla (casukila, camphor leaf), cascara sagrada, gypsophila, kasenso, crab crab (Kanshato), kaniwa, carnation, valerian (Yoshikusa), gerbera ,Pumpkin,
Kapok noki "seed", kahoku sansho (pepper), cattail
(Bright yellow), Kamiyatsude (grass), Cam cam (Duck), Color, Garlic salmon, Crow cucumber or Cinna cucumber
(Wing gourd), crow bishaku (half-summer), oats, guarana "seed", callaho (basket), karaya, garyu, karin
(Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Gyorinsai, White-floured grass), Kawajisha, Kawaratake, Kawara-Deshiko (Ishitake) or Ezokawa-Ranadeshiko (Barley, Yamoko), Kawara-ninjin (Blue-green), Kawariyomogi, Inchin-koi, Inchin-koi (Amitsu), Kantara, Candelilla, Kanto, Canna, Kanran, Rubus (Ezo strawberry, Dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry,
European raspberries), kiwi `` fruits, leaves '', cichlids (urine roots), chrysanthemums (chrysanthemums, chrysanthemums, rhododendrons), chrysanthemums, caterpillars (Azusa fruit), Rumex japonicum (roots roots), kizitsu (agar seeds), kizuta, Yellow mint, quinoa
(Quinoa), Kimame, Gymnema sylvestre, Kimenkak, cabbage, cabbage "immature fruit", caraway, gyolyu (Nishikawayanagi, Teyanagi), kiraja saponaria, kiraya, giraffe (coccus japonicum), kumquat "fruit", Kinkiju, Ginsekai, Kinbusen, Kinma, Kinmizuhiki (Senkusakusa), Kinran, Ginran, Kinryohen, Guapaba Vermelha, Guava "Fruits", Guayule, Quercus Infectria (galaxy), Kukui nut, Kugenumaran, Kucho, Kudoku Pleurotus japonicus, Crustacea), Xanthomonas chinensis (Tenmon winter), camphor tree, gooseberry "fruit", Xing carrot (Yellow lance), Kutiti river, Kunugi (Galleria japonica), Kupuas, Kubeba, Kumazasa, Vervain , Cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo Latifolia "fruit", grapefruit "fruit and leaf", buckthorn, Ilex rotunda (救必 response), Thlaspi arvense (Sekimei, Sekimeishi), ghosts (荊芥, 荊芥 ear), cockscomb
(Corolla flower, colander), geckavidin, bay (laurel), kenashisartoriibara (mountain returning), gentian, kenponashi (kigushi), koukisekoku, kishikankan
(Koji, Tachibana, Ovenimikan, Fukuromican,
Sagami Koji, Ponkan, Santara (Tachibana peel), Kosimbara (Monthly flower), Kosuihakka, Kozo `` fruit '', Kouhone (River bone), Kouhon (Straw book, Karamoto book), Koryan, Koryo Gyo (Takagura), Koenro "Fruits", Crows (Huangren), Scutellaria (yellow gon), Cowberry (Koshitachi),
Coconut “fruit”, goshuyu (gome mushrooms), gosho strawberry
(Obobonko), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock root), kobotsuduru, sesame nohagusa (genus), trash (schisandra), Bombyx or Binan vine or Wheatgrass, wheat (wheat), cola acluminata `` seed '', cola vera `` seed '', colony lya, fenugreek `` fruit '', colombo, conzulango, konbu, konjak, konfrey (final grass), sisal ( Sisal),
Rhinoceros orchid, Sakaneran (Ezosakaneran), Saxima button crane or Shina button crane or Cinnamon vine
(Gaisen), Sakura (Oshima Sakura, Yama Sakura, Oyama Sakura, Ed Higashi, Mame Sakura, Miyama Sakura,
Somei Yoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabaginran,
Sasanqua, Sadio modaka (Sawataki), Sweet potato, Sugar cane, Sugar beet, Sanpebu jujube (Sour Natsume), Saffron (Banffi, West safflower), Sapodilla, Sapote amariyo, Pomelo "fruit", Saponsou, Salmon berry "fruit", Saranshito (sand indigo) (Stab), Sawkyo Kyou (Yamakage), Sour Gourmet (Yellow Walnut), Sankaku Cactus, Sangre Degrad
(Croton), Chinese herb, Chinese cabbage (carrot), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper), Sandscon (Yamame root), Shea (Karite), Cyanoki `` fruit '',
Shiitake mushrooms (Shiitake mushrooms), Zion mushrooms (Shien mushrooms), Shikakumame, Digitalis, Shikunshi (Shikunushi), Perilla or Aojiso or Chimenjiso or Kamenmenjizo (Shiso leaf, Shiso citrus), Rosewood, Shinnaki, Shina honoki, Chinese forsythia (Forsythia), Shimeji
(Hinjimeji, Shakamejime, Hatakejimeji, Oshirojimeji, Beech Mejime, Honjimeshi, Shimotake mushroom),
Shimokuren (Spicy), Apiaceae, Potato, Shajin (Sasan), Jasmine (Matsurika), Janohige (Mugimon winter), Jurakugusa bean, Ginkgo paniculata, Shukshamitsu (sand kernel, curd sand), Juzdama, Shiro "fruit , Shunran, palm oil, ginger (ginger),
Zhouzan Hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", white oak "seed", silane (butterfly), white swan "seed", white clover (clover), white azuki bean (chicken bone grass), white banyan iris (smell iris), white clover "flower", white lupine, lupine,
Cinchona Suctil Bula, Jinchoge (Mizuka, Mizukaka,
(Sinking flower), cinnamon, watermelon (watermelon), sorrel (acidic),
Swimberry "fruits", star apple, stevia, strawberry "fruits", Suzuko (Sir Chou), horsetail (question), purslane lily (horse toothpaste, horse toothbrush), plum "fruits", sulgaran (oran), Atlantic Japanese red pine "cone", Japanese larch, Japanese Ivy, Japanese walnut, Japanese cypress, European dandelion, Horse chestnut (Marronnier), Pear "fruit", Snowflake, Elderflower (Elder), Nezu (Juniper, Morinoki), Rose of rose, Steller's stinking, Strange's mistletoe, Sturgeon's minnow or Sturgeon's minnow, Horseradish, Sperm roots (Peony root), Ginkgo (Prunus aviumensis, Duckweed, Omana sec. (Bananosecukoku) (Dendrobium, Ishibana), Cedron (Boushuboku), mallow, squirrel, senega, celery, celery, senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaves", ninninsou (daisaku), senboku, Sawka (grass fruit), elephants, buckwheat syrup, buckwheat "seed seed", some potato, broad bean, rhubarb (daikon), radish, daidai (orange peel, drought), takasago rehrigotai (south indigo indigo head), takasaburo (drought lotus) , Takatodai (Ohgi), Takawarabi (Gourd), dark sweet cherry "fruit", hollyhock, pearl mallow, thyme musk (thyme, lily scented), tachycod (Hikai), periwinkle, tamarind "seed", onion, tamshiba (Takanoki), taranoki "Fruit, leaves, root bark", tarayo (Ohafufusei, Ichihacha, Kitchingcha, Magyocha), Dahlia (Tenjiku) Tan), Taruwi, Rhynchosia Volubilis, Tanshiuchiwa, Danshen (Dan Shen), dandelion
(Kamahide) or white dandelion or moco dandelion, danmar, cherry "fruit", chigaya "fruit, root, bud",
Ginseng (carrot ginseng), chicory, chanka piedra (goldfish), tulip, chocolate stay, corn thistle (artichoke), pearl oyster (large yellow), ginseng (garlic), choreimaitake (boiled boar), Chorogi, Tsukimiso, Tsukushimakaneran, Tsukuritake (Mushroom), Tsuchiakebi, Camellia, Centella asiatica, Clover (lacquer grass), Commelina (Duck rush),
Azuki bean (red azuki bean), tsurutachiakebi, Tsudukudami
(Hemming crow), Tsuruna (Apricot radix), Ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deico, Walnut, Duberry "fruits", Amaranthus, Tencha (Thu tea), Tendai eu yak
(Crow), touga (winter gourd), vine vine, capsicum
(Pepper), sweetpotato (marigold), sugar beet, spruce beech (river cut), corn or corn hair (nanban hair), corn rat peach (sadako), gentian or gentian ginger (dragon gall), horsetail (wood bandit), Turmeric
(Vegetable root), Eucommia vulgaris (Musaka "bark, leaf, root"), Ash
(Qin skin), tomato, tragacanth, triacanthus `` seed '', tormentilla, dolnoki, troeloa mallow, tonkamame, nigeria berry `` fruit '', yam or yam (mountain drug), naguikada (butcher bloom), naginatakoju, nazuna, rapeseed, nata beans Or Tatehaki
(Sword bean), Natsumikan, Jujube (Otsuki), Naniwaibara (Kinsakurako), Navena (interrupted), Nameko, Peanut (peanut), Nanbankaramushi (Cara hemp), Nioisumire, Nigaki
(Bitterwood), nutmeg, gypstropus, Chinese chive (lark), elderberry (bone grafted tree "fruit, flower, stem, leaf"), garlic (garlic),
Leek, Nemoki or Nebu or Nebi or Nemuriki or Jigokubana (enjoyment), Thistle (Large 薊), Nozomikazura (Ryohika), Nogetou, Nodake (Pre-Hu), Novara, Nomomo,
Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hyringou, Hauchiwa, Pau Doce, Hakamauraboshi (Bone-fracturing), Hakukayumato, Hakusantori, Hakusen (Ringworm skin), Hakuruberry `` Fruit '', Hakobe (prosperous) ), Hazel (Haruko), Hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus), parsley (netherlands jelly), hadakamugi, batata, hachiku or bamboo shoots, patchouli, peppermint (light load, light load) (Leaf), Mucuna pruriens, Hanasuge (familiar mother), banana, Hana mint,
Hanabishi (Shitsuri, Shishitsuri), Vanilla Bins, Papaya, Yellow-footed squirrel (mouse koji), Pahalobobo, Hub "Whole grass,
`` Stems, leaves '', paprika, oyster oysters, pearl oysters (kazushi), yamabishi (shitsuriko), hamanasu (maikai flowers), palms, roses (roses), balatas, balata gums, agaricus (agaricus, white-bellied moss, mosquito molinosa),
Haran, Paliurus (Hamajutsu), Parietalia, Harkanran, Balsamina (Tsurureishi, Nigauri), Harunire (Japanese skin, Japanese white peel, Japanese foliage), Barbasco, Harlindou, Handaikai (Hanadaikai), Panoki, Japanese mustard ginseng , Pecan nuts, hemangana (stone garlic, iris flower), hygrumaria, higotai, hishi (hishimi), pistachio, beet, dwarf iris, dwarf daisies, daisies (daisy), hinako nokochi (cow knee) , Hydrangea cypress, Japanese cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), Himegama (incense), Himemu orchid, Pimenta "fruits", juniper, sycamore, Hiyu "fruits", chickpeas, Japanese flounder, Biroud oyster, Hirohao (Old Bald), loquat `` fruit, leaves,
Stem ", betel nut (dairy skin, 榳 榔 子), Pu'er tea, white vine (nantan), butterbur, butterbur dandelion (substratum winter flowers, subterranean winter leaves), wisteria leaflet (land grass), wisteria beans (flat bean), wisteria wisteria
(Chrysanthemum cherry, Fuyuhana), grape "fruit, peel, seed,
`` Leaf '', beech, Fuyu chinensis (caterpillar), Brazilian carrot, Brazilian palm, Brazilian elephant palm, black currant "fruit", blackberry, blanchen, plum "fruit", fulceraria, blueberry (Himesuhime), Prune, floral blanka,
Blond psyllium, bundou (mung bean), hazelnuts, hetkaran, henken, belladonna, berries "fruit", Persea, Perbianberg, pereschia grandifolia, quince or duckweed (Boisei), boysenberry "fruits", broomweed or sageweed or nectar. Or Hahagigi Kochia (ground skin), Hosairan, Housengka (Housen, Acute child, skeleton grass), Pouteria sapota, Pouteria lucuma, Honoki, Spinach, Physalis (Torone), Honoki (Japanese Atsushi, Park) , Bokeh,
Hosoba Abragiku (Bitter Yoku), Hosoba Ogura, Hosobanaokera (Soshu), Hosobanokirinsou (Keitensanshichi), Hosobabarengiku, Bodaiju (Bodhiju), Jojoba, Boriji (Rurichisha), Bordeaux, Huatulberry (fruit), Hononi Meat Juyo, Daiei), Hongsekoku
Suzuyama Ishibana), Maizuru Tennan Show (Tennansei), Maitake (Maitake), Maca, Macadamia nuts, Margaret (Mokshungik), Makri (Seagrass), Magnolia sprengueri, Masalanzuba, Masalanzuva do Ceara, Masheira De Voi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Ten Taki), Matsukasa, pine "leaves, bark, roots", Matta Orho, Matico (Cordon Sillo), Mayoram (Hanahakka), Mulberry ""Fruits", quince, malein (biloudo squid), mango, mangosteen, manzania, manju walnut, mandarin "fruits", mannoke mushrooms (reishi), Pheasant (Fructus "fruits"), psyllium or waterweed (dragon tongue grass), stag beetle. (Hanbian lotus), Misohagi (Cendula spp.), Michiyanagi or Niwayanagi (Hen), Honeywort,
Honeywort, green sapote, green peppermint, mimosa, mioga, miracle fruit "fruit", myrrh, mirobaran,
Strawberry, Makuge (Kaki), Mukunoki, Makuji (prolonged lifespan), Munya, Murasakikib or Omurasakikib (purple), Murasaki corn, Murasaki Natsuji
(Kunming chicken blood widow), Megakansa opuntica, swordfish
(Profit mother grass), Meadow grass, Evening primrose (Evening primrose), Melaleuca, Merrilot, Melon "fruit", Mousou chiku, mok giraffe, moje (pepper bok), mochinoki, mokko
(Wood incense), maple leaf, peach (peach "leaf, seed, flower,
`` Fruit ''), bean sprouts, morelo cherry `` fruits '', Moroheiya (burlap), yakawamurasakiki, yakchi (maschi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or Himeyashabushi or Obariyashabushi `` fruit, '' `` Pericarp, fruit spike '', willow, yamde (octagonal metal plate), mistletoe (willow parasite), willow (kawayanagi, weeping willow, weeping willow, red willow, willow dog, willow dog, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, willow tree, palm tree
(Tailuku nuyanagi, fox willow, doronoki), willow tree "leaf, stem", porcupine, yam koji (purple gold cattle),
Yab Tobacco (Tsuru, Tenmei), Yamabobo (Shokuryu), Yamanoki (Yamaharu), Yamamomo (Yangmeiskin), Yucca or Flavifolia, Yuzu "Fruit", Lily, Yorogusa, Ligan
(Thunder maru), lime "fruit", rye, lakanka "fruit", raspberry "leaf, fruit", latania (clamellia), rakkyo or shallot (caucasian white), lavender, longan (dragon eye meat), agave (Aonogyu agave, fukuryu agave). ), Apple `` fruit, seeds, leaves, roots '', gentian, rubus or Suavesimus (Vinosaur), thistle (Validillo higotai, Xinjiang indigo head), litchi (lichi, lichi nuclei), lettuce (chisha), red car Runt "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia
(Renzoku), Astragalus, Rhizome (Rumei), Waus palm, Locon (Reed, Rhizome), Loganberry "fruit", Rosehip (Novara), Wasabi, Cottonweed (Japanese citrus flower) and the like.

As seaweeds, there are seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (Usubaaonori, Sujiaoonori, Hiraaoonori, Bouaoonori, Hosoedaonori), Ananaosa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao midori, Genus Tsurugimido, Genus Himidoro: Hibimidoro, Genus Aosa: Anaaosa, Amiosa, Nagaaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Cyanobacteria (Suisenzinori: Suisenzinori, Aza genus, Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus: Ushikenori, Funorinoushike, genus Amanori: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As a material derived from a plant or animal material, any site derived from a genetically modified product or a cell fusion product,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(10) Marine components Seawater such as deep water, for example, seawater salt, seawater dried product, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, Kurodaite, etc.

(11) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(12) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(13) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(14) Melanin dye reducing / decomposing substance Phenyl mercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(15) Turnover promoting action / cell activating substance hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, aloe vera, sardine, horsetail, gentian, burdock, purple, carrot, hamamelis, hops, yokinin, sardine, senburi, touki, daffodil, armchair, hypericum, cucumber, pearl stalk, mannenrow, parsley) and the like.

(16) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(17) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(18) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, age extract, licorice extract, purple extract, propolis and the like.

(19) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (sarcophagi, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(20) Hair Treatment Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(21) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(22) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(23) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(24) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(25) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(26) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(27) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline pyroline Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(28) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(29) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(30) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(31) Fragrances Natural animal fragrances such as musk, civet, catrium, and ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(32) Dye / colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, endu dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(33) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory / anti-allergic agents, wound healing agents, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, etc. can be mentioned. By using them together, the effect of the present invention or other cosmetics It is expected that additive or synergistic improvement of the social effect will be achieved.

Regarding the method of addition to the cosmetic composition of the present invention, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0066]

EXAMPLES Hereinafter, production examples, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Production Example 1) Silk fiber produced by wild silkworms was crushed and powdered to 500 g of silk fiber, and 5% aqueous solution of vitamin C phosphate magnesium salt (manufactured by Sigma) 1
Add 00g and mix well. Then, after drying with a vacuum dryer, it is pulverized to obtain about 500 g of powder.

(Production Example 2) 100 g of a 5% aqueous ethanol solution of vitamin E (manufactured by Sigma) is added to 500 g of silk fiber produced by crushing and pulverizing silk fibers produced by wild silkworm, and mixed well. Then, after drying with a vacuum dryer, it is pulverized to obtain about 500 g of powder.

(Production Example 3) Silk fiber produced by wild silkworms was crushed and powdered to 500 g of silk fiber, and 5% aqueous solution of methyl parahydroxybenzoate (manufactured by Sigma) in 5% ethanol 5
Add 0 g and mix well. Then, after drying with a vacuum dryer, it is pulverized to obtain about 500 g of powder.

(Production Example 4) 50 g of a 10% aqueous solution of glycerin (manufactured by Sigma) is added to 500 g of powdered silk fiber which has been ground and pulverized, and mixed well.
Then, after drying with a vacuum dryer, it is crushed to about 50
I get 0g.

(Test 1) Whitening test In order to evaluate the whitening effect, a pigmentation inhibitory test using brown guinea pigs was carried out. "Test method and evaluation method" Brown guinea pig (WM guinea pig 13-week-old male) 1 group 3 hairs, 6 hairs in total were shaved with clippers to prepare 4 test sites (3 x 3 cm ² ). . 0.005% (w / v) 8-methoxypsoralen (Ac
72 μL (manufactured by rs) was applied to the test site in an appropriate amount, and then UVA ( ² J / cm ² ) was irradiated using a FL-20BLB lamp manufactured by Toshiba. After irradiation, an appropriate amount of the sample or control was applied to each of the two test sites. The number of times of application was once a day, and the application was performed 5 days a week for a total of 3 weeks. The day after the final application, the lightness of the skin was measured using a color-difference meter (CR-200 manufactured by Minolta) at each of three test sites, and the value obtained by subtracting the lightness of the test site measured before the test was taken as the pigmentation index. The brightness of each test site by application was measured 6 times (total number of measurements of the two test sites where the sample was applied), and the pigmentation index was calculated from the average value (the larger the index, the darker the pigmentation). Shown in 1. In addition, the sample is a powder obtained by adsorbing a 5% aqueous solution of vitamin C phosphate magnesium salt (manufactured by Sigma) on the silk fiber produced by wild silkworm obtained in Production Example 1 of the present invention in an amount of 5% in the following emulsion formulation. It was prepared by adding. In addition, as a control, vitamin C phosphate magnesium salt (manufactured by Sigma) was added to the following emulsion at 0.05% to adjust.

[0072] (Emulsion prescription) (Mass%) 1. Stearic acid 2.5 2. Cetyl alcohol 1.5 3. Vaseline 5.0 4. Liquid paraffin 10.0 5. NIKKOL TO-10 (manufactured by Nikko Chemicals) 2.0 6. Polyethylene glycol 1500 3.0 7. Triethanolamine 1.0 8. Carboxypolymer 0.05 9. Sodium bisulfite 0.01 10.Ethylparaben 0.3 11. Residue to make purified water 100

[0073]

(Test Results) As shown in Table 1, the powder obtained by adsorbing a 5% aqueous solution of vitamin C phosphate magnesium salt on the silk fiber produced by the wild silkworm of the present invention was a control (only vitamin C phosphate magnesium salt was used). It was confirmed that the pigmentation index was lower and the whitening effect was higher than that of

(Test 2) Antioxidant Test In order to evaluate the antioxidative effect, an antioxidative test using guinea pig skin was conducted. [Test method and evaluation method] Guinea pigs in one group, 3 in total, 6 in total on the back hair was clipped with clippers, and the test site (3 x 3 cm ² )
Were prepared at 6 locations. An appropriate amount of the sample or control shown below was applied to each of the test sites at two locations, and a blank area was provided at one location. Also, the number of applications is once a day, 5 days a week for a total of 3
It was applied for a week, and on the day after the final application, the lipid was extracted from the skin by using the cup method with acetone, and the effect of suppressing the peroxidation generation of lipid (lipid peroxide generation suppression rate) was tested using the TBA method. . The results are shown in Table 2. The sample was liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.) of 1 mg of powder obtained by adsorbing a 5% aqueous ethanol solution of vitamin E (manufactured by Sigma) on the silk fiber produced by wild silkworm obtained in Production Example 2 of the present invention. It was used after being dispersed and adjusted to 100 mg. As a control,
Vitamin E (manufactured by Sigma) (1 mg) was dispersed in 100 mg of liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.).

[0076]

(Test Results) As shown in Table 2, the powder obtained by adsorbing a 5% aqueous solution of vitamin E on the silk fiber produced by the wild silkworm of the present invention has a stronger lipid peroxide than the control (only vitamin E). It was confirmed that it has a production suppressing effect.

(Test 3) Antibacterial Test In order to evaluate the anti-acid effect, an antibacterial test was conducted on human skin. "Test method and evaluation method" Monitor from 20s to 5
Test site (3 x 3 cm ² ) on the inside of the left and right forearms of 5 men and women in their 0s
Was prepared in three places on each side. An appropriate amount of the sample or control (0.5 mg of methyl parahydroxybenzoate dispersed in liquid paraffin) was applied to each of the test sites in two places, and one non-application region was provided as a blank region. Also, the number of applications is 1 a day
The application was performed 7 times a week for a total of 3 weeks. The day after the final application, the skin was wiped off with acetone by a method of wiping with absorbent cotton, the number of bacteria was measured from the obtained absorbent cotton by the agar plate method, and the antibacterial effect (bacterial inhibition rate) was calculated. Shown in 3. Also, no one complained of abnormality during the test period. The sample is 1 mg of powder obtained by adsorbing a 5% aqueous ethanol solution of methyl parahydroxybenzoate (manufactured by Sigma) on the silk fiber produced by wild silkworm obtained in Production Example 3 of the present invention.
Was prepared by dispersing 100 mg of liquid paraffin (manufactured by Wako Pure Chemical Industries, Ltd.). As a control, 1 mg of methyl parahydroxybenzoate (manufactured by Sigma) dispersed in 100 mg of liquid paraffin (manufactured by Wako Pure Chemical Industries) was used.

[0079]

(Test Results) As shown in Table 3, the powder obtained by adsorbing a 5% aqueous solution of methyl parahydroxybenzoate on the silk fiber produced by wild silkworm of the present invention was compared with the control (only methyl parahydroxybenzoate). As a result, a strong bacterial inhibition rate was confirmed, and it was confirmed that it has an antibacterial effect.

(Test 4) Moisture retention test In order to evaluate moisturization, a change with time in transepidermal water loss was measured by a monitor. "Test method and evaluation method" Monitor from 20s to 3
Aqueous solution of each sample (1mL) inside the left and right forearms of 5 men and women in their 0s
Is applied three times a day. After application for 1 week, a constant temperature and humidity chamber (24
After stabilizing at ℃, 50% RH for 1 hour, TEWAMETER TM21
The measurement of transepidermal water loss (water evaporation) was started using 0 (COURAGE + KHAZAKA Electronic Gmbh). The measurement was conducted at 2-second intervals for 3 minutes, and the average value of all numerical values was taken as the TEWL value of the test site. Further, each blank was measured under the same conditions before application of the sample, and the results are shown in Table 4 (the lower the amount of water evaporated, the higher the moisturizing property of the skin). Also, no one complained of abnormality during the test period. The sample is 1 m of powder obtained by adsorbing a 10% aqueous solution of glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) on the silk fiber produced by wild silkworm obtained in Production Example 4 of the present invention.
The product prepared by dispersing g in 100 mL of purified water was used.
As a control, glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) 0.1
% Aqueous solution was used.

[0082]

(Test Results) As shown in Table 4, the powder of silk fiber produced by wild silkworm of the present invention adsorbed with a 10% aqueous solution of glycerin had a water evaporation amount of the skin as compared with the control (glycerin only). It was confirmed to be small. Therefore, it was confirmed that transpiration of water related to moisturization is prevented.

(Test 5) Safety Test (1) Primary Skin Irritation Test Wild silkworm silk fiber powder containing various components obtained in Production Examples 1 to 4 has a dry matter concentration of about 5.0 W / V%. Thus, it was applied to the skin of Japanese white rabbits (female, 1 group, 3 animals, body weight around 2.3 kg) whose backs were shaved, prepared with purified water. Evaluation was carried out 24, 48, and 72 hours after application using erythema and edema as indices based on the Draize criterion. As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 6) Safety Test (2) Skin Cumulative Irritation Test Similarly, wild silkworm silk fiber powder containing various components obtained in Production Examples 1 to 4 had a dry matter concentration of about 5.0 W / V%. 0.5 mL / mouse was applied once a day, 5 times a week to the skin of Hartley guinea pigs (female, 1 group, 3 animals, weight 320 g) prepared with purified water so that .. Apply 2
The shaving was performed over the week and the shaving was performed on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. As a result, it was judged that no erythema and edema were observed in any of the animals for 2 weeks, and that there was no problem regarding cumulative skin irritation.

(Test 7) Safety test (3) Single-dose toxicity test Wild silkworm silk fiber powder containing various components obtained in Production Examples 1 to 4 of the present invention (purified water to a concentration of 12.5%) 16 mL / kg per animal before preparation,
Ddy mice (male and female, 1 group 5) fasted for 4 hours
Orally administered to a mouse (5 weeks old), and the onset and degree of toxicity symptoms were observed over time. As a result, in all mice, 14
No abnormalities were observed during the day, and the results of autopsy were also normal. Therefore, the LD ₅₀ was 2,000 mg / kg or more, and the substance was judged to be safe.

(Prescription Example) Production of Cosmetic Composition According to the above-mentioned evaluation results, the following prescription examples are shown. Indicated. Further, the present invention is not limited to these.

[0088] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Production Example 1       B: Production example 2       C: Production Example 3       D: Production Example 4       * Any one of A to D silk fiber powder 5.0    11. Perfume amount    12. Residue to make purified water 100

[0089] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Silk fiber produced from wild silkworm (Eri silkworm or Saku silkworm) 3.0    14. Hypericum leaf or stem 70% ethanol extract 3.0    15. Silk protein enzymatic degradation solution 3.0    16. Pork placenta water extract 1.0    17. Antibacterial / antiseptic agent (paraoxybenzoic acid ester)    18. Residue to make purified water 100

[0090] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Silk fiber powder from Production Example 4 3.0     6. Choji bud hot water extract 1.0     7. Grapefruit fruit or leaf hot water extract 1.0     8. Tochu leaf hot water extract 1.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0091] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Silk fiber powder 2.0 of Production Example 2     6. Silk fiber powder 2.0 of Production Example 4     7. Hirugi root bark or rhizome 30% ethanol extract 1.0     8. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 1.0     9. Yuzu fruit 30% ethanol extract 1.0    10. Grape stem or leaf 30% ethanol extract 1.0    11. Sansho peel or fruit 30% 1,2-pentanediol extract 1.0    12. Kiwi fruit 50% ethanol extract 1.0    13. Antibacterial (lactoferrin solution) appropriate amount    14. Antibacterial and antiseptic (paraoxybenzoic acid ester)    15. Perfume (Western light water) Appropriate amount    16. Residue to make purified water 100

[0092] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. Silk fiber powder from Production Example 3 3.0     6. 50% 1,3-butylene glycol extract of whole cedar plant 3.0     7. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     8. Gentian whole plant 50% ethanol extract 2.0     9. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0    10. Yeast 50% 1,3-butylene glycol extract 1.0    11. Allantoin 0.2    12. Astringent (zinc sulfocarbonate) 0.2    13. Antibacterial and antiseptic (thiamin lauryl sulfate)    14. Perfume (Lavender water) Suitable amount    15. Residue to make purified water 100

[0093] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2.POE sorbitan tetraoleate 0.3     3. Sorbitol 1.0     4. Ethanol 15.0     5. Silk fibers produced by wild silkworms 3.0     6. Hypericum flower or spike 50% propylene glycol extract 2.0     7. 50% Propylene Glycol Extract Solution of Hyogi Pericarp or Fruit 2.0     8. Red radix rhizome or root bark 50% propylene glycol extract 2.0     9. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0    10. Sage whole plant 50% ethanol extract 1.0    11. Bodaiju flower or fruit 30% ethanol extract 1.0    12. Ascorbic acid 0.2    13. Astringent (calamine) 0.1    14. Antibacterial / preservative (phenoxyethanol)    15. Perfume (apple water)    16. Residue to make purified water 100

[0094] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Silk fiber produced by wild silkworm 3.0     8. 50% propylene glycol extract of rhizome or rhizome 2.0     9. Peony root 50% propylene glycol extract 2.0    10. Water mallow flower or leaf 50% propylene glycol extract 2.0    11. Chamomile flower 50% propylene glycol extract 2.0    12. Comfrey leaf and stem 50% ethanol extract 1.0    13. Pig placenta enzyme decomposition solution 1.0    14. Silk protein alkaline solution 2.0    15. Camphor 0.2    16. Phenol 0.03    17. Antibacterial and antiseptic agent (photosensitive element 201 & 401)    18. Perfume (bodhi water) Suitable amount    19. Residue to make purified water 100

[0095] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5. Silk fiber powder of Production Example 0.5     6. 50% glycerin extract of rhizome or rhizome 3.0     7. Hypericum flower or spike 50% glycerin extract 1.0     8. Raspberry fruit 50% diglycerin extract 1.0     9. Choji Bud 50% Diglycerin Extract 1.0    10. Unshu mandarin orange peel 50% 1,3-butylene glycol extract 1.0    11. Green tea leaf hot water extract 1.0    12. Peach leaf hot water extract 1.0    13. Pork placenta hot water extract 1.0    14. Antibacterial and antiseptic (paraoxybenzoic acid ester)    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0096] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Silk fiber produced by wild silkworm 3.0     8. Ginkgo leaf 50% glycerin extract 2.0     9. Hyacinth flower or spike 50% glycerin extract 2.0    10. Safflower whole plant 50% ethanol extract 2.0    11. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0    12. Eucalyptus leaf or stem 30% ethanol extract 2.0    13. Royal Jelly 50% Ethanol Extract 1.0    14. Trehalose solution 1.0    15. Antibacterial and antiseptic (paraoxybenzoic acid ester)    16. Perfume (Chamomile water) Suitable amount    17. Residue to make purified water 100

[0097] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Silk fiber powder 3.0 of Production Example 1     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Panax ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Liquid shea fat 1.0    15. Dipotassium glycyrrhizinate 0.1    16. Antibacterial and antiseptic (acrinol) 0.1    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0098] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Silk fiber produced by wild silkworm 2.0    11. Silk fiber produced by wild silkworm 2.0    12. 50% propylene glycol extract of rhubarb or rhizome 1.0    13. Dodami leaf hot water extract 1.0    14. Shiso leaf 50% propylene glycol extract 2.0    15. Purple roots 50% propylene glycol extract 2.0    16. Soybean seed fermented soybeans 1.0    17. Glycyrrhetinic acid 0.1    18. Pig placenta enzymatic degradation solution 1.0    19. Antibacterial (lactoferrin solution) 0.5    20. Antibacterial and antiseptic (Zinc pyridione)    21. Perfume (clove water) appropriate amount    22. Residue of purified water 100

[0099] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Silk fiber powder 0.3 of Production Example 4     8. Apple fruit 20% 1,3-butylene glycol extract 2.0     9. Kawara Artemisia leaf 20% 1,3-butylene glycol extract 2.0    10. Rosehip fruit 30% ethanol extract 1.0    11. Kakkon hot water extract 2.0    12. Glycyrrhizic acid 1.0    13. Apricot kernel 0.1    14. Antibacterial and antiseptic (2-phenoxyethanol) 0.1    15. Perfume (oncoming water) Appropriate amount    16. Residue to make purified water 100

[0100] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6.Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14. Silk fiber produced by wild silkworm 0.1    15. Silk fiber produced by wild silkworm 0.1    16. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Oil-soluble chamomile flower or leaf extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    18. Oil-soluble licorice root or rhizome extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    19. Edetate 2.0    20. Glycyrrheteric acid 1.0    21. Antibacterial and antiseptic (photosensitive element 401) 0.1    22. Perfume (Mugwort water)    23. Residue to make purified water 100

[0101] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Alkanediol 1.0     5. Silk fiber powder 1.0 from Production Example 3     6. 70% of the bark or rhizome of the cedar bark 1,3-butylene glycol extract 1.0     7. Seaweed 70% 1,3-butylene glycol extract 0.5     8. Armature leaf or stem 70% 1,3-butylene glycol extract 0.5     9. Soybean seed fermented natto fermented liquid 0.5    10. Aloe pulp 70% ethanol extract 2.0    11. Polyethylene powder 0.5    12. Hydroxypropyl chitosan solution 0.5    13. Amino acids (arginine, glycine, glutamine, etc.) 0.5    14. Monoammonium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (undecylenic acid, phenol)    16. pH adjuster    17. Fragrance (lavender water) Suitable amount    18. Residue to make purified water 100

[0102] (Prescription example 15) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Silk fiber produced by wild silkworms (saku silkworms or silkworms) 1.0     5. Toki rhizome 70% 2,3-butylene glycol extract 0.5     6.Kakkon 70% 1,3-butylene glycol extract 0.5     7. Chlorella 70% 1,3-butylene glycol extract 0.5     8. Fish (salmon or flounder) -derived hydrolyzed collagen solution 0.5     9. Amino acids (glutamine, proline, lysine, etc.) 0.5    10. Monoammonium glycyrrhizinate 0.1    11. Antibacterial / antiseptic (undecylenic acid, phenoxyethanol)    12. pH adjusting agent    13. Perfume (orange water) Suitable amount    14. Purified water 100 residue

[0103] (Prescription example 16) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Silk fiber powder 3.0 of Production Example 1    15. White birch bark 70% dipropylene glycol extract 1.5    16. Cornflower leaf 50% propylene glycol extract 0.5    17.Kakkon 50% propylene glycol extract 0.5    18. Yuzu fruit 50% dipropylene glycol extract 0.5    19. Antibacterial / antiseptic agent (benzyl paraoxybenzoate)    20. Fragrance (jasmine water) Suitable amount    21. Residue to make purified water 100

[0104] (Prescription example 17) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 23.8     4.A: Production Example 1       B: Production example 2       C: Production Example 3       D: Production Example 4       * Any one of A to D silk fiber powder 2.0     5. Chamomile flowers 10% 1,3-butylene glycol extract 1.0     6. Burdock root hot water extract 0.5     7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     8. Mallow flower or leaf 50% propyl alcohol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Peony root or leaf hot water extract 0.5    11. Ethyl para-aminobenzoate 0.2    12. Antioxidant (Butyl hydroxytoluene) Suitable amount    13. Perfume (Mixed perfume)

[0105] (Prescription example 18) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Silk fiber produced by wild silkworm (Eri silkworm or Tasar silkworm) 1.0    16. Dokudami leaf hot water extract dry powder 0.2    17. Wenzhou tangerine peel or fruit hot water extract dry powder 0.2    18. Yukinoshita whole grass hot water extract dry powder 0.2    19. Antibacterial and antiseptic (phenoxyethanol) 0.1    20. Perfume (Rose water) Suitable amount    21. Residue to make purified water 100

[0106] (Prescription example 19) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Silk fibers produced by wild silkworms (saku silkworms or silkworms) 2.0     7. St. John's wort 20% 2,3-butylene glycol extract 2.0     8. Hot water extract of root bark or rhizome 2.0     9. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    10. Toki root 30% 1,4-butylene glycol extract 2.0    11. Hydroxypropyl chitosan solution 1.0    12. Hyaluronic acid solution 1.0    13. Dipotassium glycyrrhizinate 0.1    14. Antibacterial and antiseptic (photosensitive element 101)    15. pH adjusting agent    16. Perfume (sandalwood water)    17. Purified water

[0107] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Silk fibers produced from wild silkworms (saku silkworms or silkworms) 3.0     7. Scented flower 50% 1,3-butylene glycol extract 1.0     8. Astragalus leaf 50% 2,3-butylene glycol extract 1.0     9. Mackerel fruit 30% 1,2-butylene glycol extract 1.0    10. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    11. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0    12. Soybean seed natto fermented liquid 0.5    13. Hydroxyethyl chitosan solution 0.5    14. Fish (salmon or tuna) -derived hydrolyzed collagen solution 0.5    15. Trehalose solution 0.5    16. Hydrolyzed silk solution 0.5    17. Antibacterial and antiseptic (benzalkonium chloride)    18. Perfume (grape water) Suitable amount    19. Residue to make purified water 100

[0108] (Prescription example 21) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Wild silk (Tasar silkworm or anafe) silk fiber 3.0     7. Hyogi leaf or stem 50% 1,3-butylene glycol extract 3.0     8. Western bodhi flower or fruit 50% 1,4-butylene glycol extract 1.0     9. Olive leaf 50% 1,2-butylene glycol extract 1.0    10. Loquat leaf 50% ethanol extract 1.0    11. Sharon fruit or flower 50% 1,3-butylene glycol extract 1.0    12. Trehalose solution 1.0    13. Hydrolyzed keratin solution 1.0    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Chamomile water) Suitable amount    16. Residue to make purified water 100

[0109] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Wild silk (Tasar silkworm or Cricula) silk fiber 3.0     6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0110] (Formulation Example 23) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.1,2-hexanediol 1.0     6. Assembly leaf or stem 50% 1,2-butylene glycol extract 3.0     7. Panax ginseng root hot water extract 3.0     8. Lemongrass leaf 50% 1,3-butylene glycol extract 1.0     9. Apple fruit 30% ethanol extract 1.0    10. Sesamorin 0.3    11. Wild silk (Tasar silkworm or anafe) silk fiber 0.5    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0111] (Formulation Example 24) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Silk fiber produced by wild silkworm (Eri silkworm or Anafe) 0.3     5. Comfrey leaf or stem 50% ethanol extract 3.0     6. Yuzu leaf or fruit 50% ethanol extract 3.0     7. Soybean seed fermented soybeans 2.0     8. Hamamelis leaf or bark hot water extract 2.0     9. Comfrey leaf or stem 50% ethanol extract 2.0    10. Loquat leaf 30% ethanol extract 2.0    11. Carpronium chloride 0.3    12. Pantethine solution 0.3    13. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0112] (Prescription example 25) Heartonic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Silk fiber produced by wild silkworm (Eri silkworm or Tasar silkworm) 1.0     5. Clove leaf 30% ethanol extract 2.0     6. Antibacterial / antiseptic (propyl paraoxybenzoate) 0.2     7. Residue to make purified water 100

[0113] (Prescription example 26) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: Production Example 1       B: Production example 2       C: Production Example 3       D: Production Example 4       * Any one of A to D silk fiber powder 2.0     7. Hypericum perforatum fruit or pericarp hot water extract 3.0     8. Lavender flower or flower spike hot water extract 1.0     9. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0    10.Augon rhizome or root bark 50% ethanol extract 1.0    11. Soybean seed hot water extract 1.0    12. Carboxymethyl chitin solution 1.0    13. Chicken wicker extraction solution 0.2    14. Pantethine solution 0.2    15. Antibacterial and antiseptic (phenoxyethanol)    16. Perfume (sage water) appropriate amount    17. Residue to make purified water 100

[0114] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. 50% sesame whole plant 50% glycerin extract     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Silk fiber produced by wild silkworm (Eri silkworm or Saku silkworm) 1.0     6. Capsicum tincture 0.5     7. Resorcin 0.5     8. Dipotassium glycyrrhizinate 0.5     9. Carboxymethyl chitin solution 0.5    10. Collagen protein enzymatic degradation solution 2.0    11. Pig hematin solution 0.5    12. Pig mucin solution 0.5    13. Amino acids (arginine, glycine, glutamine, etc.) 0.5    14. Antibacterial and antiseptic (paraben) 0.1    15. Perfume (rosemary water)    16. Residue to make purified water 100

[0115] (Prescription example 28) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Hirugi root bark or rhizome hot water extract 3.0     3. Whole assembly 60% ethanol extract 3.0     4. Peony rhizome or root bark 60% ethanol extract 3.0     5. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     6. Soybean seed fermented soybeans 1.0     7. Silk fibers produced by wild silkworms (Eri silkworms or moth silkworms) 1.0     8. Cantharis tincture 0.5     9. Pantothenic acid derivative 0.2    10.β-glycyrrhetinic acid 0.2    11. Resorcin 0.2    12. Hydroxyethyl chitosan solution 0.2    13. Elastin hydrolyzate 0.2    14.Keratin protein enzymatic degradation solution 0.2    15. Preservative (paraben) 0.1    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0116] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 6.0     4. Wild silkworm (Eri silkworm or Cricula) produced silk fiber 3.0     5. Sorbitol 2.0     6. Peach leaf 70% ethanol extract dry powder 1.0     7. Dye (Gunjo green) Appropriate amount

[0117] (Formulation example 30) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Silk fibers produced by wild silkworms (saku silkworms or silkworms) 3.0     5. Hyaluronic acid powder 3.0     6. Sambucus nigra flower or berries hot water extract dry powder 1.0     7. Apple juice powder 1.0     8. Dye (Gunjou, chromium hydroxide)     9. Perfume (grape water) Suitable amount

(Prescription example 31) A gauze or a liniment cloth for covering and protecting was impregnated with a prescription liquid in which an appropriate amount of an ethanol solution of silk fiber produced by wild silkworms (Eri silkworm or Clicula), an antibiotic, an anti-inflammatory agent, etc. was impregnated, and the wound area was injured. Attach to. Alternatively, an ethanol solution of silk fiber produced by wild silkworms (Eri silkworms or Clicula) may be directly sprayed locally and covered with gauze or the like.

[0119] (Prescription example 32) Toothpaste                                                              weight%     1. Silicic anhydride 20.0     2.Sorbit solution 50.0     3. Glycerin 10.0     4. Wild silk (Eri or Tasar silkworm) produced silk fiber 5.0     5. Sodium lauryl sulfate 2.0     6. Saccharin sodium 0.05     7. Sodium carboxymethyl cellulose 1.5     8. Fragrance suitable amount     9. Coloring agent    10. Purified water

[0120] (Prescription example 33) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Hypericum leaf or stem hot water extract dry powder 0.1     7. Wild silkworm (Eri silkworm or Cricula) silk fiber 0.1     8. Green tea leaf hot water extract dry powder 0.1     9. Dye (Gunzhou Green) Appropriate amount    10. Residue to make purified water 100

[0121] (Prescription example 34) Dish detergent for mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Hot spring root water hot water extract dry powder 1.5     6. Silk fiber produced from wild silkworm (Eri silkworm or Saku silkworm) 3.0     7. Rubus pericarp or fruit hot water extract dry powder 2.0     8. Residue to make purified water 100

(Test 8) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test was conducted by a woman who suffers from dry skin, lack of gloss and tension, or a woman who suffers from spots, freckles, and dark skin, each of whom is aged between 40 and 40. It was carried out by applying an appropriate amount of the emulsion of Example 1 on the face for 3 months. As a control,
The emulsion obtained by excluding the product of the present invention and formulated by the same method was used. In addition, the evaluation method is based on the following criteria,
The results are shown in Tables 5 to 6, and the numerical values in the table represent the number of people. still,
No one complained of skin abnormalities during the period of use.

[Effect of improving skin feel] Effective: Dry skin and gloss / tension of the skin were increased, and the skin was improved. Slightly effective: Dry skin and gloss / tension of the skin were slightly increased, and the skin was slightly improved. Ineffective: No change from before use.

"Blemish freckles & skin color improvement effect" Effective: The freckles freckles and the skin color were white and reduced. Slightly effective: The spots, freckles, and skin color were whitened and slightly reduced. Ineffective: No change from before use.

[0125]

[0126]

(Test Results) As shown in Tables 5 and 6, cosmetics containing the silk fiber produced from wild silkworm of the present invention and one or more of a whitening agent, an antioxidant, an antibacterial agent and a moisturizing agent. The composition significantly improves dry skin, gives the skin gloss and tension,
It was also confirmed that the stains and freckles were improved and the skin color was reduced to white.

[0128]

EFFECT OF THE INVENTION A cosmetic composition containing the silk fiber produced from wild silkworm of the present invention in combination with any one or more of a whitening agent, an antioxidant, an antibacterial agent and a moisturizing agent is excellent. It has a whitening effect, an antioxidant effect, an antibacterial effect, and a moisturizing effect. Furthermore, it significantly improves dry skin, imparts shine and tension to the skin, and also improves stains, freckles, and reduces skin color to white. can do. Therefore, it is effective in preventing skin aging and can be applied to preparations in any form (medicines, quasi drugs, cosmetics). In addition, it is safe for humans and animals, and can also be used for general food and drink.

─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. ⁷ Identification Code FI Theme Coat (Reference) A01N 25/34 A01N 25/34 B 37/40 37/40 A61K 7/02 A61K 7/02 J 7/06 7/06 7/075 7/075 7/08 7/08 7/11 7/11 7/26 7/26 7/42 7/42 7/50 7/50 (72) Inventor Kenji Terai Kanazawa, Ishikawa Prefecture 1-5 Tamagawacho Mitani Sangyo Co., Ltd. (72) Inventor, Kuichiro Uchida 2-13-67, Shiromachi, Mihara-shi, Hiroshima Tosco Co., Ltd. Central Research Institute (72) Kohei Hasebe, Masamasa, Motosu-gun, Gifu Prefecture No. 1 at 318 Asagi Ichimaru Falcos Co., Ltd. F-term (reference) 4C083 AA032 AA072 AA082 AA112 AA122 AB032 AB152 AB172 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC032 AC072 AC082 AC092 AC432 AC102 AC112 AC122 AC132 AC172 AC182 AC212 AC422 AC352 AC352 AC212 AC422 AC432 AC352 AC352 AC472 AC482 AC532 AC542 AC552 AC582 AC612 AC642 AC692 AC742 AC782 AC792 AC842 AC852 AC862 AC902 AC932 AD022 AD092 AD112 AD212 AD272 AD322 AD332 AD412 AD432 AD442 AD451 AD452 AD512 AD532 AD552 AD642 AD652 AD662 BB47 BB48 BB51 CC01 CC04 CC05 CC06 CC07 CC19 CC23 CC25 CC32 CC41 CC05 DD39 CC39 CC41 CC05 DD39 DD33 4H011 AA02 BA01 BB06 BC03 BC18 BC23 DA02 DC01 DD07

Claims (5)

[Claims] 1. A silk fiber produced by wild silkworm and a whitening agent.
A cosmetic composition comprising at least one species. 2. A cosmetic composition comprising silk fiber produced by wild silkworm and one or more antioxidants. 3. A silk fiber produced by wild silkworm and an antibacterial agent 1.
A cosmetic composition comprising at least one species. 4. A silk fiber produced by wild silkworm and a moisturizer.
A cosmetic composition comprising at least one species. 5. Wild silkworms are Saku silkworms (Antheraea pernyi), Eri silkworms (Samia cynthia ricini), Tasar silkworms (Anthraea).
mylitta), Anaphe (Anaphe reteculata), Muga silkworm (Antheraea assama), Cricula trifenes
trata), one or more selected from silkworm silkworm (Antheraea yamamai). 5. The cosmetic composition according to claim 1, wherein