JP2003104835A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new safe melanin production inhibitor or fibroblast proliferation inhibitor, and to provide cosmetics containing the same. SOLUTION: This melanin production inhibitor or fibroblast proliferation inhibitor contains (A) one or more plant extracts selected from Aloe barbadensis, Prunus amygdalus Batsch, Flammulina velutipes, Pleurotaceae eryngii, Seamum indicum L., Dioscorea japonica Thunb. or Dioscorea batatas Decne, Lentinus ebobes Singer (Cortinellus shiitake P. Henn.), Lyophyllum shimeji, Taraxacum officnale Weber, Sambucus nigra L., Cnidium officinale Makino, Ojaponica (Schult.) Griseb., Morus bombycis, Agaricus bisporus, Capsicum annum, Ligusticum acutilobum, Prunus persica, Houttuynia cordata, Pholiota nameko, Panax ginseng, ophiopogon tuber, Agaricus campestris, Agaricus blazei Merrill, Grifola frondosa, Hibiscus syriacus, and coix seed, or one or more substances selected from a chlorella extract, a yeast extract, and water-soluble β-1,3-glucan derivatives, and further (B) one or more substances selected from other plant extracts, whey, N-acetyltyrosine derivatives, and seaweed extracts.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention provides, as essential components,
(A) Aloe vera, almond, enoki mushroom, eringi, sesame, sanyaku, shiitake mushroom, shimeji mushroom, dandelion, elderberry, senkyu, senburi, sohakuhi, tsukuritake mushroom, capsicum, touki, tonin,
One or more kinds of plant extract or chlorella extract selected from Dokudami, Nameko, Carrot, Bakumondo, Agaricus, Himematsutake, Maitake, Mukuge, Yokuinin,
Yeast extract, any one or more selected from water-soluble β-1,3-glucan derivative, and further (B) oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, horse chestnut, rhubarb, soybean, Clove,
One or more kinds of plant extracts selected from turdus kudami, tormentilla, grapes, buttons, hops, willow trees, yasha, yukinoshita, or one or more kinds selected from whey, N-acetyltyrosine or a derivative thereof, or Aonoori, Anaaosa, and Uchiuchiwa. , Giraffe, kotojitsunomata,
Combined use of one or more seaweed extracts selected from kelp, horse mackerel, agar beetle, hijiki, hijirimen, hibamata, wakame (however, excluding the use alone as an essential component) significantly suppresses the production of melanin pigment, The present invention also relates to a novel and safe melanin production inhibitor or fibroblast proliferation promoter having a fibroblast proliferation promoting action, and a cosmetic composition containing the same.

[0002]

2. Description of the Related Art Factors that determine the color of human skin include the amount of melanin in the epidermis, blood flow in capillaries, food-derived pigment (carotene), and thickness of the stratum corneum. One of the important factors is the melanin pigment. So-called liver spots (spots), freckles (freckles), and skin pigmentation after sunburn are caused by the activation of pigment cells in the skin, which markedly enhances the production of melanin pigments. It is one of the major skin problems for women.

This melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) existing in the basal layer of the epidermis, the root of hair and the outer root sheath. During the process of melanin pigment production, tyrosinase activates tyrosine in the pigment cell (melanocyte) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further auto-oxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally becomes a melanin pigment. The generated melanin is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, increases as the basal cells divide and become spinous cells, reaches the stratum corneum, and then falls off with detachment of the stratum corneum. It is supposed to go.

Therefore, in order to prevent or ameliorate liver spots (spots), freckles (freckles) and dark skin of the skin, the production process of melanin is inhibited. Alternatively, it is conceivable to lighten the already generated melanin. Therefore, based on these ideas, various whitening components have been conventionally proposed. For example, kojic acid and its derivatives, ascorbic acid and its derivatives, tocopherol and its derivatives, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract and plant extract (Arnica, Althea). , Aloe, sardine, brown grass, chamomile, licorice, gardenia, ginger ginger, shikon, ginger, birch, senkyu,
Genosho, Psycho, Sancha, Toki, Sengoku, Elderberry, safflower, garlic, adlay, litchi, log wood) and the like are known.

[0005] Further, individual aging or various diseases associated therewith is correlated with aging of all cells that can divide (decrease in division rate and cell function), and the purpose is to prevent aging at the cellular level. As a result, many cell activating agents are being searched for. Among them, cell growth factor is one of the cell activating agents, and various factors have already been confirmed. The connective tissue hydrolyzate by the present applicant (Japanese Patent Laid-Open No. 62-84024), water soluble in organs such as thoracic line and spleen, etc. Protein (JP-A-63-188697, 63-1
88698), or bovine placenta extract (JP-A 03-141299), and further, an extract of bovine brain or bovine pituitary gland / cow (JP 01-17599A).
8) are known, and these are used for quasi-drugs and cosmetics.

[0006]

However, the above-mentioned whitening ingredients have poor stability and solubility in the prescription system, give off an offensive odor and color due to precipitation and decomposition, and are not sufficiently effective at the biological level. However, there was a problem in terms of safety, such as skin irritation, which was not satisfactory. Further, as for the cell growth ability, many of them are derived from animal systems, and as the plant system derived from the present applicant,
Cucumber is disclosed as a cell activating substance such as cell engraftment rate and colony formation promoting action (Japanese Patent Laid-Open No. 02-117686).
At present, there are few plant-based, seaweed-based, fermented products, etc. having cell growth ability.

[0007]

In view of these circumstances, the present inventors have developed a useful plant or seaweed, which has a melanin production inhibitory action, a fibroblast proliferation promoting action, a fermented product, etc., and as a result, (A) Aloe vera, almonds, enoki mushrooms, eringi, sesame, sanyaku, shiitake mushrooms, shimeji mushrooms, dandelions, elderberry, senkyu, senburi, sohakuhi, Tsukutake mushrooms, capsicum,
One or more plant extracts selected from Touki, Tounin, Dokudami, Nameko, Carrot, Bakumondou, Agaricus, Himematsutake, Maitake, Mukuge, Yokuinin, or Chlorella extract, yeast extract, water-soluble β-1,3-glucan In addition to any one or more selected from derivatives,
(B) oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, holly cypress, rhubarb, soybean, clove, clover, tormentilla,
One or more plant extracts selected from grapes, buttons, hops, willow trees, yashas, and Yukinoshita, or whey, N
-A combination of one or more kinds selected from acetyltyrosine or a derivative thereof, or one or more kinds of seaweed extracts selected from Aonori, Anahusa, Sea Urchin, Ginkgo cypress, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hibamata and Wakame ( However, by using as an essential component alone, the production of melanin pigment is significantly suppressed, and it also has a fibroblast proliferation-promoting action, and further reduces white spots, freckles or skin on the skin (whitening effect). ),
The present invention also provides a novel and highly safe melanin production inhibitor or fibroblast proliferation promoter capable of improving dry skin and giving gloss and tension to the skin, and a cosmetic composition containing the same. The invention was completed.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION "Aloe vera" used in the present invention means a plant of the genus Aloe of the family Liliaceae:
Aloe vera `` A. barbadensis Mill. (= A. Vera L.) and its variants (A. Vera L. var. Chinensis (Haw.) Berger), (A. sap
onaria Haw.) leaves or stems are used,
In addition, A. arborescens Mil
l.), socotra aloe (A. perryi Baker), natal aloe (A. bainesii Th. Dyer), aloe dichoto (A. dichoto)
homa L.), Aloe marlothi Berger,
A. rupestris Baker, A. spinosissima Hort., A. plicatilis Mill., A. aeruperifolia
sperifolia A. Berger), aloe capitata Bak.var.cipolinicola H.Perr., aloe splendens Lavranos, aloe humilis mill. (A.mitr
iformis Mill.), Aloe Welliegata (A.variegata)
L.), Cape Aloe (A.ferox Mill.), Aloe Africana (A.africana Mill.), Aloe spicata (A. spicata B.
aker), (A.haworthiodes Baker), (A.succotrina La
It is also possible to use aloe leaves or stems such as m.,).

The term "almond" (also known as "hen peach") used in the present invention means Rosaceae and Prun.
us) plant: almond (P. amygdalus Batsch) seeds are used.

The term "enokitake mushroom (also known as enokitake mushroom)" used in the present invention means "F.
es) Umbrella or handle, fruiting body, mycelium, sclerotium.

The term "eringii" used in the present invention means the genus Pleurotaceae and the genus Pleurotu.
Plants of s): An umbrella or a handle of P. eryngii, a fruiting body, a mycelium, and a sclerotium are used.

The term "sesame (also known as sesame)" used in the present invention means a plant of the sesame family (Pedaliaceae), genus (Seamum): sesame (S. indicum L.) or (S. orientale L. ) Seeds are used.

Further, the "San yak (also known as:
`` Yamadaku '' means plants belonging to the family Dioscoreaceae and genus Dioscorea: D. japonica Thun.
b.) or Chinese yam "D.batatas Decne. (= D.opposite Thun
b.) ”root or rhizome (root carrier), root bark, tuber.

In addition, "Shiitake (also known as:
Shiitake) is a plant of the family Tricbolomataceae and Lentinus: L. ebobes Singer (= Cor
tinellus shiitake P. Henn.) "umbrella or handle, fruiting body, mycelium, sclerotium.

The term "Shimeji (also known as" occupied land ")" used in the present invention refers to the family Tricbolomataceae and the genus Shimeji.
(Lyophyllum) plants: Hongshimeji (L. shimeji), Shakashimeji (= Senbonshimeji) (L.fumosum), Hatakeshimeji
(L.descastes), Oshiroshimeji (L. connatum), or
Plant of Hypsizigus genus: Beech Shimeji (Hm
armoreus), an umbrella or a handle of H. ulmarius,
Use fruit bodies, mycelium, and sclerotium.

Further, the "dandelion used in the present invention.
(Also known as Kamikoei) "means the genus Dandelion (Compositae).
(Taraxacum) plants: dandelion (T. officnale We)
ber) roots or those obtained from the whole plant are used, but in addition, the same genus Shirobana dandelion (T. albidum Dahlst.),
Kansai Dandelion (T. japonicum Koidz.), Mouko Dandelion (T. monogolicum Hand.-Mazz), Keirin Dandelion (Tm
onogolicum Hand.-Mazz.var.corniculatum Nakai, T.as
iaticum Dahls.), Canto Dandelion (T.platycarpum Da
hlst.), Miyama Dandelion (T. alpicola Kitam.), Akami Dandelion (T. laevigatum DC.), Ezo Dandelion (T. venustu)
m Koidz.), Sina dandelion `` T.sinicum Kitag. (= T.sinic
um Dahlst.), T. helerolepis Nakai et H. Koidz. '',
Odasum Dandelion (Necka Dandelion) "T.platycarpum Di
els, T.erythrodium Kitag., et al., T. ceratophorum D
C. ", Manshu USHIRO Dandelion" T. pseudo-albidum Kit
ag., T.pseudo-albidum Kitag.var.lutescens Kitag.,
T. ohwianum Kitam., T. disrectum Ledeb. ”, And dandelion (T. cuspidatum Dahlst.), Etc., can also be used.

[0017] The "Sambucus nigra" used in the present invention is also used.
(Alias: bone graft) "means the honeysuckle family (Caprifoliaceae)
Plants of the genus Sambucus: Sambucus
(ra L.) fruits, flowers or stems and leaves, but other species of the same species, S. racemosa L. subs.
p.sieboldiana (Miq.) Hara (= S.sieboldiana (Miq.) Blume
ex Graebn.) '', S. sieboldiana (Miq.) Blum
e ex Graebn.var.miquelii (Nakai) Hara), American elderberry (S.candensis L.), Japanese elderberry (S.javanica Re)
inw.ex Bl.subsp.chinensis), Elderflower (S.william)
It is also possible to use fruits, flowers or leaves of sii Hanse).

The term "senkyu (aka: river kyu)" used in the present invention means a plant of the genus Cnidium of the Umbelliferae family (C. officinale Makino).
Use the roots, rhizomes or root bark of.

Further, the "assembly (also known as:
'' Is a Gentianaceae genus (Op
helia) plant: assembly "O. japonica (Schult.) Griseb.
(= Swertia japonica (Schult.) Makino) ”is used.

Further, the "sohakuhi (also known as mulberry bark)" used in the present invention means plants of Moraceae and genus Morus: M. bombycis Koidzumi and M. alba L. .)
Alternatively, the root, rhizome, or root bark of the same genus plant is used. For example, shimawa (M. australis Poir.), Logwa (M. latifoli)
a (Bur.) Poir.), Mukomonwa (M. mongolica (Bur.) Schnei
d.), Black Miwa (M. nigra L.) Red Miwa (M. rubra L.)
Etc. can also be used.

The term "Tsukuritake (also known as mushroom)" used in the present invention means "Agaricacea".
e), plants of the genus Agaricus: Tsukuritake (A. bispo)
rus) umbrella or handle, fruiting body, mycelium, sclerotium.

Further, "capsicum (also known as pepper)" used in the present invention means plants of Solanaceae and Capsicum: capsicum "C. annuum L. = (C.fru).
tescens L.) '' or a variety thereof, obtained from fruits of varieties.
siforme Mill.), (C.annuum L.var.conoides Irish),
(C.annuum L.var.fasciculatum Irish), bell pepper `` Ca
nnuum L.var.angulosum Mill. = (C.annuum L.var.grossu
m Sendt.) ”, (C. annuum L.var.longum Sendt.) and the like.

The term "touki" (also known as "toki") used in the present invention means "Umbelliferae" and "genus Angeli".
ca) plant: Use roots, rhizomes, or bark of A. acutiloba Kitagawa or other closely related plants.

Further, the "tonin (also known as:
(Momojin) "means a plant of the genus Prunus of the Rosaceae family: peach (P.persica Batsch) or peach (P.persica Batsch).
sch var.davidiana Maximowicz), and Santo `` P.dav
idiana (Carr.) Franc. "seeds are used.

In addition, "Dokudami (alias:
`` Drugs '' (Saururaceae), Houttu (Houttu)
ynia): whole plants of H. cordata Thunberg are used.

Further, the "nameko (also known as" spores ")" used in the present invention means the plants of the family Mothaceae (Strophariaceae), plants of the genus Pholiota: nameko, P. nameko, A. adiposa, Numerisugitakemodoki (A.aurivella),
Porphyra (P. lubrica), Porphyra (P.le)
nta) umbrella or handle, fruiting body, mycelium, sclerotium.

The "carrot (also known as:
"Ginseng, ginseng)" is a plant of the genus Araliaceae (Araliaceae) ginseng (Panax): Panax ginseng "P.ginseng CAMeyer (= P.schinseng Nees)" Use the one that you made.

Further, "Bakumondou (also known as: Makumon Fuyu)" used in the present invention: Liliaceae, Ophiaceae (Ophi)
opogon) plant: O. japonicus Ker-Gawler
Or roots, rhizomes and root bark of other plants belonging to the same genus).

Further, the "haratake" used in the present invention means
Agaricus family (Agaricaceae), plants of the genus Agaricus (Agaricus): agaricus (A. campestris), white-bellied agaric (A. arv)
ensis), an umbrella or a handle of A. abruptibulbus, fruit bodies, mycelia, and sclerotium.

Further, the term "Himematsutake (also known as Himematsutake)" used in the present invention means a plant of the family Agaricaceae and a genus Agaricus: A. blazei Merril.
Use the umbrella or handle of l), fruiting bodies, mycelium, and sclerotium.

Further, the "maitake (alias:
`` Maitake) '' means the genus Sarcophagous (Grifola frondosa),
Plants of the genus Grifola: Gum frondosa umbrellas or stalks, fruiting bodies, mycelium, and sclerotium are used.

In addition, the term "Mukuge" (also known as "kobuki") used in the present invention means Malvaceae and Hibiscus.
Plants: Starling: Flowers or fruits of Kaki (H. syriacus L.),
Those obtained from bark, leaves, and roots are used.
fa L.), (H.arnottianus A.Gray), (H.kokio Hillebr.)
Etc., flowers or fruits of plants generally called hibiscus, bark, leaves, and roots can also be used.

"Yokuinin" used in the present invention is a plant of the family Gramineae or genus Juzdama (Coix):
Hatomogi `` C.lachryma-jobi L.var.ma-yuen (Roman) Stap
f (= C.ma-yuen Roman) ”seeds are used.

Further, "Uyaku (also known as mulberry, Tendai mulberry)" used in the present invention means plants of the family Lauraceae and genus Lindera: L. strychnifol.
ia (Sieb.et Zucc.) F.Vill. (= Benzoin strychnifolium (S
ieb.et Zucc.) O. Kuntze) ”roots or rhizomes and root bark.

Further, the "oolong tea (also known as oolong tea)" used in the present invention means the genus Theaceae and the genus Tea.
Plant of a): Tea or tea tree "T. sinensis L. (= Camelli
a sinensis L.) '' leaves or branches and leaves, and in general, raw leaves may be semi-fermented. What was dried and used.

The "olive" used in the present invention means
Leaves and branches of olives (O. europaea L.), plants of the genus Oleaceae and olives (Olea), branches, leaves, fruits, seeds, and whole plants are used.

Further, the "parentheses (alias:
(Kudzu)) means legumes (Leguminosae), Kudzu (Pueraria)
Plants: roots, rhizomes, or root bark of persimmon (P. lobata (Willd.) Ohwi) excluding the pericardium are used.

[0038] Further, the term "Koromo mugwort" (also known as 茵 蒿) used in the present invention means Compositae and Artemisia genus.
temisia) plant: wormwood (A. capillaris Thunb.)
Or, use the flower heads or spikes of other closely related plants.

In addition, the "Kinanoki (alias:
'' Is a Rubiaceae, Cinchon.
a L.) plants: red linden (C. succirubra Pavon et Kl)
(Otzch) branches or trunks, roots, and bark are used.
ex Trimen '', (C. officinalis L.), (C. calysaya Wed
d.) etc. can also be used.

The term "Clara" (also known as "Ginseng") used in the present invention means legumes (Leguminosae) and genus Sophor.
a) plant: Clara "S.flavescens Aitin (= S.angustifol
ia Sieb.) ”roots or rhizomes and root bark.

The "Violet cypress" used in the present invention
And, azalea family (Ericaceae), plants of the genus Vaccinium (Vaccinium): flowers or spikes of Vaccinium cypress (V. myrtillus L.), pericarp, fruit, stem, leaf, branch, branch, stem, bark, rhizome, root leather,
Roots, seeds, or whole plants are used, but in addition, the same species plant, V. smallii A. Gray var glabrum Koidz., Can be used.

In addition, the "Daiou (alias:
'' Is a Polygonaceae, Rheu genus.
m sp.) plants: roots or rhizomes of rhubarb (R. officinale Baillon), root bark, tuberous roots are used. .), Palm leaf rhubarb (R. palmatum
L.), Japanese maple rhubarb (R.tangaticum Maximowicz), green rhubarb (R.undulatum L.), shinshu rhubarb (R.co.
reanum Nakai × R.palmatum L.), (R.emodi Wall.), (R.
macrocarpum A. Los.), (R.moorcroftiana Royle), (Rn
obile Hook. f.et Thoms.), (R.webbiannum Royle), wave leaf rhubarb (R.frazenbachii Munt.), (R.tataricum),
Interspecific hybrids such as (R. maximoviczii) can also be used.

The term "soybean" (also known as soybean) used in the present invention means legumes (Leguminosae) and genus Soybean (Glycine).
Plant soybean "G.max L. Merrill (= G.hirsta Maxim.)"
Seeds of.

In addition, the "Clove (also known as:
(Cloves, cloves, cloves) '' means Myrtacea (Myrtacea)
e), plants of the genus Syzygium Gaertn .: Clove “S. aromaticum (L.) Merrill et Perry (= Eugenia caryo
phyllata Thunberg) ”flowers or buds.

In addition, the term "Pleurotus cornucopiae" (also known as "Heisei crow") used in the present invention means "Polygonaceae" and "Genus genus".
lygonum) plant: P. multiflorum Thunb.
Use rhizomes or root bark, roots, and tubers.

The term "tormentilla" used in the present invention refers to Rosaceae and Potilla L.
Plants: Potentilla tormentilla "P. tormentill
a Schrank (= P.Silvestris Necker) ”or roots, rhizomes, tubers, but other plants belonging to the same genus
(P.chinensis Ser.), Iwakinbai (P.dicknsii Fr.etS
av.), Tsutiguri (P. discolor Bunge), Tsurumijimushiro
(P. fragarioides L.), honey bee (P. freyniana Bo
rnm.), golden leafhopper (P. fruticosa L.), black pearl bud (P. da)
vurica (Nestl.)), Miyakinbai (P.matsumurae Th.Wo
lf), Chishima bean leaf (P. megalantha Takeda), Kijimushiro (P. sprengeliana Lehm.), Strawberry (P. sundaica)
(Bl.) OK) or the like can also be used.

The term "grape" (also known as "grape") used in the present invention means the family Vitaceae and the genus Viti.
s) plants: American grapes (V.labrusca L.), European grapes (V.vinifera L.), Yama grapes (V.coiguet)
iae Pulliat), Shrimp Crane (V. ficifolia Bunge var. lo)
bata (Regel) Nakai), V. flexuosa Thu
nb.), Amazon Crane (V.saccharifera Makino), (V.labr
uscana Bailey) flower or spike, pericarp, fruit, stem, leaf,
Branches, leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used.

Further, the "button (also known as peony skin)" used in the present invention means a button family (Paeoniaceae) and a button genus (Paeon).
Plant of ia): Button "P.moutan Sims (= P.suffruticosa A
ndrews) "or root bark / rhizome.

The term "hops" (also known as "Hananus vulgaris") used in the present invention means a fruit ear or female ear, gland of hop (H. lupulus L.) plant of Moraceae genus Humulus. Use the body.

In addition, the "Michiyanagi (also known as: Willow tree, hen storage)" used in the present invention means Polygonacea.
e), Polygonum, P. avicular
e) flowers or spikes, pericarp, fruits, stems, leaves, branches, branches, stems,
Bark, rhizome, root bark, roots, seeds or whole plants can be used.

In addition, the term "Yasha" (also known as "Yasha") used in the present invention refers to the family Betulaceae and the genus Alnu.
s Mull.) plant: Yashabushi (A. firma Sieb.et Zucc.)
The fruit or pericarp of A. crisp, and the ear of the fruit are used, but in addition to the same species, A. pendula Matsumura, A. sieboldana Matsumura, A. crisp
a (Aiton) Pursh.maximowiczii Hara), Japanese alder
(A. hirsuta (Spach) Pupr.), Alder (A. japonica (Th
You can also use unb.) Steud.).

The term "Yukinoshita (also known as tiger ear grass)" used in the present invention means S.stolonifer (S.stolonifer), a plant of the genus Saxifragaceae
a Meerb.) whole plant.

Aloe vera, almonds, enokitake mushrooms, eringii, sesame seeds, sanyaku, shiitake mushrooms, shimeji mushrooms, dandelions, elderflowers, senkyu, senburi, soyakuhaku, tsukutake mushrooms, capsicum, toki, tounin, dokudami, nanamedo, nanamedo, sardines, sardines, and sardines, used for use in the present invention. , Agaricus, agaricus, oyster mushroom, sagebrush, yokuinin, oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, hollyhock, rhubarb, soybean, clove, periwinkle, tormentilla, grape, button, hop, honeywort, yasha, yusha, yusha The selected one or more plant extracts means various parts of each plant (whole grass, flowers, head flowers,
Spikes, female spikes, spikes, fruits, buds, pericarp, glands, stems, leaves,
Branches, branches, leaves, stems, bark, rhizomes, tubers, root bark, roots, tuberous roots, seeds, umbrellas or stalks, fruiting bodies, mycelia, sclerotia, etc. Or, as it is or after crushing,
It was extracted with a solvent.

"Chlorella" used in the present invention means green plant phylum (Chlorophyta), green alga net (Chlorophyceae),
Chlorococcales, Oocystaceae, Chlorella, unicellular green algae with a diameter of 3-10 microns, such as Chlorella vulgaris and Chlorella pyrenoidosa. C. Pyrenoidosa), chlorella ellipsoidea, etc. can be used.

Further, "Aonori" used in the present invention means Chlorophyta (Chlorophyta), Chlorophyceae, Chlorophyceae, Ulvales, Ulvaaceae, Genus Ente.
Romorpha), a hollow tubular body whose walls consist of a single layer of cells. For example, E. linza J. Aga
rdh), Suziahonori (E.prolifera J.Ag.), Hiraaonorii (E.compressa Greville), Bow Aonori (E. intestina)
Lis Link), Hosoeda Aonori (E.crinita J. Ag.), etc. are listed as representative ones.

The term "Anaosa" used in the present invention means Chlorophyta, Chlorophycea.
e), Ulvales, Ulvaaceae, Ulva, and Ulva (U. pertusa K).
Jellman's) body is a membranous parenchyma-like tissue consisting of two layers of cells, which are widely spread and have many holes, forming large communities mainly on the rocks in the lower part of the intertidal zone.

The term "sea urchin" used in the present invention refers to the phylum Phalaeophyta, Isogenerata.
e), Dictyotales, Dictyoceae (Dictyoles)
The body is flat and fan-shaped, with no central ribs, and the body is initially single but may split into several pieces as it grows. The growth edge of the body is engulfed on one side of the body by a large number of growth point cells arranged in a line on the edge. The body consists of one to several layers of cells, with concentric rows of hair.
The base of the body is covered with brown faux-felt like a felt, for example, P. arborescens Holmes, P. australis Hauck, P. au.
stralis var. cuneata), P. boryana
Thivy in Taylor), Kona Miuchiwa (P.crassa Yamada),
Okinawa (P. japonica Yamada), Usuyukichiwa (P. japonica Yamada)
minor Yamada), P. stipitata Tanaka
et Nozawa in Tanaka), P.ryukyuana YP Lee et Kam
Ura and the like are listed as typical ones.

Further, the "giraffe" used in the present invention means Rhodophyta and Floridea.
e), Gigartinales, Sorieriacea
e), classified as Eucheuma, the body is cylindrical or oblate. The entanglement at the base of the branch is a light algal body that is densely populated with short conical or spinous protrusions.
(E.serra J.Ag.), E. amakusaensis
Okamura), Kirinsai (Ryukyu Tsunomata) (E.dent
Typical examples are iculata (Burman) Collins et Hervey), and juniper giraffe (E. cupressoideum Wv Bosse).

Further, "Kotoji Tsunomata" used in the present invention
And Rhodophyta, the true red algae (Floridea)
e), Cucurbitaceae (Gigartinales), Cyperaceae (Gigartina)
ceae), Gigartina, which is classified into the genus Gigartina.
lata (Holmes) Kim), which has a covering tissue on the scab, the body is crowded, flattened, forked several times at the upper part of the body, and the axilla is a round algal body. Be raised as.

The term “kelp” used in the present invention means Phloephyta, a heterogeneous generation (Heterogenerata).
e), kelp order (Laminariales), kelpaceae (Laminariacea)
e), which is classified into the genus Laminaria, a leaf that has no hair plexus and has a mucous cavity and no central ribs, a root is fibrous, and a stem does not diverge. Ares
choug), Resiub (L. japonica Areschoug var.ocho
tensis Okamura), Hosomomebu (L. religiosa Miyab)
e), Mitsuishikonbu (L. angustata Kjellman), etc. are listed as representative ones.

The "suginori" used in the present invention means
Rhodophyta, Rhodophyta, Florideae, Gigartinales, Gigartinacea
e), categorized in the genus (Gigartina), the buds protrude from the surface of the body, and the body refers to algal bodies that normally branch in a feather shape,
For example, G. tenella Harvey, Shikinori (Gt
eedii (Roth) Lmx.), Kainori (G.intermedia Sur.),
G. mikamii Yoshida 〔= G.verrucosa (Mik
ami) Kim, non (K tzing) Setchell et Gardner]), etc. are representative.

Further, the "agar beetle" used in the present invention means
Male and female gametophytes classified into the Rhodophyta (Rhodophyta), the true Rhodophyta (Florideae), the order Agaris (Gelidiales), and the family Amanita (Gelidiaceae), and the sporophytes parasitic on it,
There are three generations of tetraspores whose outer shape is exactly the same as gametophyte, and they form algae that are called a locus on the surface of the rock and propagate asexually. In the genus Agaris (Geridium), for example, G. amansii Lamouroux, G. subcostatum Okamura, G. japonicum Ok
amura) etc., for example, in Pterocladia, for example, P. tenuis Okamera and P. densa Okame
(Ra) etc., in the Yatabella genus (Y. hirsuta Okamura), etc., the genus Acanthopeltis
Then, for example, in the case of Gelidiella, such as A. japonica Okamura, for example, G. ace
rosa (Forsskl) Feldmann et Hamel) is a typical example.

The "Hijiki" used in the present invention is classified into the phylum Phalaeophyta, Cyclosporeae, Fucales, Sargassaceae, and Hizikia. Hijiki (H. fusiforme Okamur
In a), a submarine forest with a body length of 50 cm to a long one exceeding the height is hung and has roots, stems, leaves, and air bubbles (floating bags),
Typical examples of the bubbles include spindle-shaped or club-shaped ones in which cylindrical twigs are swollen.

Further, "Hijirimen" used in the present invention means Rhodophyta and Rhodophyta.
e), Cacreteles (Cryptonemiales), Centipedeidae (Gra
teloupiaceae) (or sometimes referred to as the family Cacreito (Cryptonemiaceae), genus (Cyrtymenia)), is divided into the whole cortex of tetrasporangia in C. sparsa Okamura) The one with wrinkles of crepe shape on the surface.

"Hibamata" used in the present invention means
Phaeophyta, Phalaeophyta, Cyclosporeae, Fucales, Fucaceae, Genus Hibatama
(Fucus), F. vesiculosus (or F. distichus Linnaeus subsp. Evanescens (C. Agard
h) Powll) body is membranous, with midribs, body length 20-50
A typical example is a cold seaweed seaweed that grows in the middle of the intertidal zone.

Further, "wakame" used in the present invention means Phloephyta, a heterogeneous generation (Heterogenerata).
e), kelp (Laminariales), seaweed family (Undaria), refers to algal bodies that have hair plexuses and mucous glands in the leaves and create folds in the lower part of the body, for example, seaweed (U. pinnatifida Sur
ingar), Hirome (U.undarioides Okamura), Blue sea turtle
(U.peterseniana Okamura) etc. are listed as typical ones.

The seaweed extract used in the present invention (Chlorella, Aonori, Anahusa, Sea Urchin, Giraffe,
Kotoji Tsunomata, kelp, horsetail, Astragalus, hijiki, hijirimen, hibamata, wakame) are seaweed bodies that have been crushed and then extracted. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts or seaweed extracts may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc. , Lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin or hydrous polyhydric alcohols, acetone, ethyl acetate It is desirable to use one or a mixture of two or more selected from various organic solvents such as. However, when the inclusion of an organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water, or , Those that have been exploited and extracted are also acceptable. Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the above-mentioned various plants or seaweeds which have been hydrolyzed and extracted by enzymatic decomposition, those which have been hydrolyzed by acid or alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol or the like, or an arbitrary mixture thereof to the extract after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

The "yeast extract" used in the present invention is a yeast of the genus Sacharomyces (for example, brewer's yeast, sake yeast, wine yeast, baker's yeast, etc.).
Extracts obtained using an aqueous solvent from digests obtained by self-digesting yeast, including extracts obtained simply by using an aqueous solvent, obtained by digesting yeast with a proteolytic enzyme An extract obtained from the digested product using an aqueous solvent and an extract obtained from the digested product obtained by hydrolyzing yeast with an acid using an aqueous solvent can be used. The aqueous solvent used for extraction is water, ethanol, 1,3-butylene glycol, propylene glycol, glycerin, or any mixture thereof. The yeast extract may be an extract containing a solvent, or may be in the form of a paste or powder without the solvent. As components, various enzymes,
Nucleic acid related substances such as proteins, RNA, nucleosides, nucleotides, coenzymes, vitamin B1, vitamin B2,
Vitamin B6, nicotinic acid, vitamins such as inositol, various amino acids, glutathione, lipids, minerals and other components are included.

The "water-soluble β-1,3 used in the present invention is also used.
"Glucan derivative" is a low molecular weight oligomer that hydrolyzes β-1,3-glucan to be water-soluble, β-1,3
-At least one or more of hydroxyethylation, hydroxypropylation, carboxymethylation, sulfuric acid esterification, and phosphoric acid esterification for the hydroxy group (-OH) released on the molecule of glucan or a low molecular weight oligomer thereof. It is a compound in which a water-soluble functional group is introduced by employing a chemical modification means. The β-1,3-glucan contains β-1,3-bonded glucopyranose as a main chain and β-1,6- or β-1,4-bonded glucopyranose as a side chain. It doesn't matter. For example, the cell wall of yeast (genus Sacharomyces), Alcaligenes faecalis
Curdlan produced by microorganisms such as var.myxogenes and Agrobacterium, and Euglena gracili
s, Euglena gracilis var.bacillaris, Euglena viridi
β-1,3-glucan such as paramylon produced by s) can be used, and the low molecular weight oligomer of β-1,3-glucan has a glucose unit of 30 or less, preferably 20 or less. good. And, the average substitution degree of the functional group in the compound in which the water-soluble functional group is derived is 0.1 to 5.
About 0 (per glucose unit sugar) is preferable, and it is about 0.2 when considering stability over time dissolution and compatibility with other components.
3 are particularly suitable for external use such as cosmetics.

The "whey: whey" used in the present invention means (a) raw milk or skim milk powder aqueous solution, and lactic acid bacteria (Lactoba).
cillus bulgaricus) fermented milk obtained by inoculating and cultivating solid milk to obtain whey or powder. (B) An aqueous solution of milk protein or an aqueous solution of skim milk powder and glucose is treated with Streptococcus thermophilus or Lactobacillus.
(Lactobacillus bulgaricus) Fermented liquid filtered. (C) Milk contains proteolytic enzymes (Chymosinn) and lactic acid bacteria (Lactobacillus bulgaricus, Lactococcus lactis, Lac)
eptococcus thermophilus, Leuconostoc mesenteroides)
Whey protein is removed from whey obtained by fermentation by adding any one of them or a combination thereof, and dried.

The "N-acetyltyrosine or derivative thereof" used in the present invention is represented by the following structural formula 1, and may be dry powder, water, alcohol, glycol, etc. It can be provided in a form of being dissolved in a solvent, an emulsion (emulsified form), or the like.

[0075]

[Chemical 1]

(A) Aloe vera, almond, of the present invention,
Enokitake, eringii, sesame, sanyaku, shiitake,
Shimeji, dandelion, elderberry, senkyu, senburi, sokuhaku, Tsukutake mushrooms, capsicum, touki, tounin, dokudami, nameko, carrot,
Bakumondou, agaricus, Himematsutake, hops, maitake mushrooms, bokweed, botanical extracts of Chlorella, chlorella extract, yeast extract, water-soluble β-1,3-glucan derivative, melanin production inhibitor, or fibroblast In addition to being used as a growth promoter, it can be further contained in a cosmetic composition, but the content thereof is not particularly specified, and a melanin production inhibitor, a fibroblast growth promoter or a cosmetic composition It varies slightly depending on the type, quality and expected degree of action, and is usually 0.001% by mass or more (hereinafter referred to as%), preferably 0.2 to 20%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

Similarly, (B) oyster, oolong tea, olive, cuckoo, wormwood, linden, of the present invention,
Clara, holly, cypress, rhubarb, soybean, clove, ginkgo, tormentilla, grapes, buttons, pops, willow, yasha, each plant extract of Yukinoshita, or whey, N-acetyltyrosine or its derivative,
Or Aonori, Anahosa, Sea Urchin, Giraffe,
For seaweed extracts of Kotoji Tsunomata, kelp, horse mackerel, Astragalus, hijiki, hijirimen, hibamata, wakame seaweed extract, it can be used as it is as a melanin production inhibitor or a fibroblast proliferation promoter, and can be further contained in a cosmetic composition. , Its content is not particularly specified, and slightly different depending on the type of melanin production inhibitor, fibroblast proliferation promoter or cosmetic composition composition type, quality, and expected degree of action, usually 0.001 Mass% or more (hereinafter referred to as%), preferably 0.2 to 20%. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The dosage form and form of the melanin production inhibitor, fibroblast proliferation promoter or cosmetic composition of the present invention are arbitrary, and include capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, It can be used by mixing it in the form of cream, ointment, sheet or the like.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) For baths to be used Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpastes, mouthwash, mouthwashes and the like.

The melanin production inhibitor, fibroblast proliferation promoter or cosmetic composition of the present invention may be added to the above-mentioned essential components, if necessary, within a range not impairing the effects of the present invention.
The components and additives exemplified below can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50%.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac fat, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide. Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials. These are processings (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose of use, the type of product to be provided, the processing to be performed later, etc. In general, water, methanol, ethanol, propyl alcohol or isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, Ai (Aiba), Blue vine (Keifufuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Gotiri), Aotsutsurafuji (Kibomi), Aotenma, Acacia, Akashouma
(Akasoma), red currant `` fruit '', red clover, red peach (logwood), red wrinkle (red bud), red pine or red madder or red madder (Akane grass root), red radish or dio (ground yellow), agi (Awe), red pine, Akinire (resilient skin), Aguay Guassu, Aguahe (Omi Tenguyashi), Akebei (Kizu), Asa (Asako Jin), Malva morning glory or morning glory (chocolate), Hydrangea (hydrangea),
Ashitaba (tomorrow leaf), adzuki bean (red azuki bean), asunaro, acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna),
Anise, Abiu, Abiurana, Brassica, Abemaki "fruit", Avocado, Ama, Amacha (sweet tea), Amateur Crane, Amadocoro (Bamboo bamboo), Amana (Growing honey), Amaranthus (Hiyu, Hagatetou, Himegateu, Senninkok,
Sugimori Gate, Hoso Ao Gate, Ao Gate,
Haribiyu, Aosuzuran, Amaranthus hippocondriacus), Amygasa lily or fritillaria (shellfish), aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai (Souzuki), Angelica, Apricot Or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakouzorina (geijutsu), squid or chinensis (intestinalis), rush (wick-grass), knotweed
(Kojo root), yew (first place), strawberry, fig (flowerless “fruit, leaf”), figs (first), hibiki (winter aoi), yakuso (one medicinal herb), ginkgo (ginkgo “seed, leaf”) ), Itohimehagi (distinct), locust bean, Inunazuna (Taylexi), Inubiyu (Honagainubiyu), rice `` seed, seed coat '', inondo `` seed '', Ibukitakusou, nettle, ylang ylang, iwatobacco (Iwahibiwa) or Iwahiba or Iwahiwa (Kashiwa), common bean, fennel (incense), wheat (Chibana), prickly eel (Sanryo), Uguisukagura `` fruit '', Pleurotus cornucopia, turmeric (Utsukusa), duckweed
(Ukiwa), Usubasaishin or Keirinsaishin or Oshushusaishin (spicy), Usvena oyster, Usbenitachioi, Uchiran, Utsubogusa (summer hay), Udo or Shishido (anchored, singly, singly), Unyadegat (Uncaria, Cats) Claw), Uba tea, Japanese plum (Ume "seed, fruit pulp"), Vladimir, Uruga (Urbanberry), Unshiu mandarin orange (Chikin), Umbo, Estragon, Ezo kogi (Ezo Goka), Ezo suzuran, Echinashi (Euphoria japonicum), Ebisugusa or Cassia tora (Kiseiko), Elcampre, Elderberry "fruit", Elemi, Enju (Sophora, Sophora rice), Pea, Scutellaria or Orchidaceae (Yellow radish), Narucoyuri or Kagiwa Kurumabanarukoyuri (Yellow essence), Spicy Sasanoyuki Or Yuki Sasano, Oren (Yellow), Oga Houken, Giant crow (calocon), Ooguruma (civil engineering incense), Otsudurafuji (self-defense), plantain (carp, carp grass), white thistle (Ginshu oak, white-headed man), hazel (harbor), prickly pear, cactus Okera or Okera (white syrup), Spodoptera litura (banaba), Coccinellus communis (grain herb), Oomiacatetsu, Omihawthorn or Hawthorn (yamazushi),
Omiyashi, barley (barley), oka, okazeri (snake bed), okra "fruit", oguruma (overturning), okururigogotai (bamboo stink, indigo stab), hypericum or sycamore, or hypericum perforatum (younger cut grass) , Odori Koso (intermittent), Onami fir (Blue ear), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Haikai), Oninogagara
(Tianma), Oniyuri or Sasayuri or Hakatayuri (yuri),
Onoelan, Ononis, halibut, Ominaeshi
(Soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch biu, Dutch honeywort, oregano, orange "fruit, pericarp", cauliflower (ripe ground yellow), cacao "fruit, pericarp, seed", oyster (persimmon) `` Leaf ''), Kagizura (fishing hook), Kakidoshi or Kantorisou (Lotus grass), Kakiran, Gaku hydrangea, Cassia, Casinoki (Yuomi `` fruit ''), Gajutsu (muddle), Kashiwa (hammer tree, mallet leaf) , Cascarilla, Cascara Sagrada, Gypsophila, Kasengou, Crabgrass (Kanshato), Kaniwa, Carnation, Kanosou (Yoshikusa), Hippopotamus, birch or Weeping birch (white birch),
Gerbera, pumpkin, kapok cypress `` seed '', kahoksansho (pepper), gama (yellow), chamomile or Roman chamomile, chamomile (grass), camu camu (duck), color, larvae, crow cucumber or cichlid cucumber
(Wing gourd), crow bishaku (half-summer), oats, guarana "seed", callaho (basket), karaya, garyu, karin
(Wood melon), garcinia, kawamidori, kawajisha, kawaratake, kawaranadeshiko (ishitake), or zokawaranadeshiko
(Ball wheat, Tsubame bark), Kawara carrot (Blue lacquer), Kansu (sweet pepper), Kanzo (liquorice), Kantara Asa, Candelilla, Kanto, Canna, Kanran, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiro strawberry, Maple strawberry, European raspberry) ), Kiwi `` fruit,
Leaves ”, Cichlid cucumber (melon root), kyokyo (bellflower, bellflower), chrysanthemum (chrysanthemum, chrysanthemum, chrysanthemum)
Chrysanthemum, Catalpa (Azusa fruit), Rumex (Yotei root), Pheasant tree (Boomerum), Kizuta, Yellow mint, Quinoa (quinoa),
Kihada (yellow oak), Kimame, Gymnema sylvestre, Kimenkaku, cabbage, cabbage "unripe fruit", caraway,
Cucumber, Goryu (Nishikawayanagi, Teiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kenshi Kogusa), Kumquat "fruit", Kinkiju, Ginsekikai, Kinbusen, Kimma, Kinmizuhiki (Senjakusa), Kinran, Ginran, Kinryohen, Guapaba・ Vermelha, guava "fruit", guayule, quercus infectoria (gallid), kukui nuts, kugenumaran, kuko (lilies, husks, limbs, skeletons), kusagikazura (tenmen winter), camphor tree, gooseberry "fruits" , Carrot (yellow flower),
Kutiti River, Gardenia (Yamasuko), Kunugi (Kusou), Kupuasu, Kubeba, Kumazasa, Bear vine (Chipweed), Cranberry "fruit", chestnut "seed, fruit, astringent skin", Curculigo latifolia "fruit", grapefruit ""Fruits and leaves", buckthorn, black anemone
(Necessity of rescue), Kamehiba hikoshi or Kurobana hikoshi koshi or Hiki koshi (prolonged life grass), Gumbai nazuna (Sekimei, Sekimeishi), Kaigai (Maggot, 芊 芥, 芊 芥), Keitoka (crown flower, poultry), Geckavidin, Bay Laurel (Laurel)
Kenashisarutoriibara (Tsukuryo rye, mountain return), Gentian,
Genoshoko (Old bird grass), Kenponashi (Kigushi), Koukisekekoku, Kishikankan (Koji, Tachibana, Ovenimikan, Fukuromikan, Sagamikoji, Ponkan, Santara (Tachibana peel)), Koushinbara (Monthly flower), Kosuihakka, Kozo fruit ”, Koucha (black tea), Kouhone (river bone), Kouhon (Straw book, Karamoto book), Kouryan, Koryokyo (Kora ginger), Cilantro“ fruit ”, Koren
(Kohren), Scutellaria (yellow gon), cowberry (Koshitachi), coconut "fruit", goshuyu (goshu 萱), gosho strawberry (covered bonito), pepper (pepper), cosmos, copaiba balsam,
Coffee `` seed, leaf '', kobushi or magnolia (spicy sauce), burdock (burdock, burdock root), peony vine, sesame stag beetle (genus), trash (schisandra), rapeseed vine or vine chile or pine grass, wheat (wheat), rice or rice bran `` Red rice bran, white rice bran ", rice oil, cola acluminata" seed ", cola
Bella "seed", colony lya, fenugreek "fruit", Colombo, Conzurango, kelp, konjac, comfrey
(Final herb), sisal (sisal asa), saihairan, sakaneran (ezosakaneran), saxima button vine or cinna button vine or sinensenso (weapon), cherry tree
(Oshima cherry, Yamazakura, Oyama cherry, Ed Higashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "leaf, flower, fruit, bark (cherry bark)", cherry, pomegranate, sasan, sasanbagin , Sageomodaka (Sawaki), sweet potato, sugar cane, sugar beet, sanpeitojutsu (sour citrus fruit), saffron (bancoflower, west safflower), sapodilla, sapotea mario, pomelo "fruit", sabonsou, salmonberry "fruit", salinach
(Rima), Saranshito (sand indigo stab), Salvia (sage),
Pleurotus cornucopiae (mountain bell pepper), gurney (mountain walnut), Sankaku cactus, Sangre degrad (croton), Sankuyouso, Sanshichin ginseng (37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper), Sandscon (yamazu) Root), shea
(Karite), Cyanoki `` fruit '', Zion (Shion), Lentil, digitalis, Shikunshi (Kushikuniko), Perilla or Aojiso or Chimenjizo or Catamendiso (Shiso leaf, Shiso),
Rosewood, linden, cinnabar, syringa syringa (continuous), magnolia (spicy), spirea, potato,
Peonies (peony), shajin (jasmine), jasmine (matsurika), juvenile cowpea, gypsophila, shukushamitsu (sand kernels, crispy sand), juzdama, palm "fruits", shunran, sycamore, ginger (ginger),
Zhouzan Hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", white oak "seed", silane (butterfly), white swan "seed", white clover (clover), white azuki bean (chicken bone grass), white banyan iris (smell iris), white clover "flower", white lupine, lupine,
Shirominanten (Nami Tenmi), Shinkona Sakushirubura, Jinchoge (Mizuka, Mizukaka, Shichohana), Cinnamon, Cinnamomum cassia (cinnamon skin), watermelon (watermelon), honeysuckle
(Gold and silver flower, Shinobi winter), sorrel (acidic), swim berry “fruit”, star apple, stevia, strawberry “fruit”, Suzuko (Sir Xu), horsetail (question), purslane.
(Horse toothpaste, horse toothpaste), plum "fruit", surgaran
(Oran), Scots pine "cone", Japanese larch, Japanese apricot, Japanese walnut, hawthorn, horse chestnut (horse chestnut), pear "fruit", pine nutmex, Amaranthaceae (juniper, morimatsu), Achillea millefolium (Milfoils), Roses of roses, Steller's fowls, Stuffed mistletoes, Sturgeon minnows or Steller's squirrels, Horseradish, Sekisho (Ishikon root), Ginkgo (Prunus avium L., Gypsophila L., Oanabakusoku, Owanawasekoku, Honsekokuku, Koshikokusekoku, Koshikokusekoku (Kibana no Sekkoku) (Dendrobium, Ishibuchi), Cedron (Boushuboku), mallow, hirohasenega, senega, seri, celery, senshinren (scenting ream), sendan, sennin cactus, senna `` Real, leaf ", clematis terniflora (Daitade), Senboku, Soka (Kusahate), Zougechuu,
Soshinsoubai, buckwheat "seed fruit", some potatoes, broad bean, radish, daidai (orange skin, drought), takasagogorurihigotai (south indigo stab head), takasaburo (drought lotus), takatodai
(Ohji), Takawarabi (in Japanese), dark sweet cherry "fruit", hollyhocks, pearl oysters (thyme, lily scent), tadikoro (hikai), tachinyanagi, tamarind "seed", onion, tamshiba (spicy), taranoki "fruit" , Leaf, root bark, tarayou (Oba winter blue, one-leaf tea, bitcho tea, bitter tea), dahlia (tenjiku button), tarwi, tankard bean, tanchiuchiwa, tanjin (danshen), danmaru, cherry "fruit", chigaya " Fruits, roots, buds ", Chixet carrot (Chicken ginseng), Chicory, Chanka piedra
(Kidachi-kansou), tulip, chocolate stay, Korean thistle (Artichoke), Korean elm (蕺 褷), Korean mugwort (芥 leaves), Choreimaitake (boiled boll), Chorogi, Tsukimiso, Tsukushikaneran,
Acacia nigra, Camellia, Centella asiatica, Clover (lacquer grass), Commelina (Duck rush), Azuki bean (Red adzuki bean), Clams citrus, Tsuruna (Apricot), Ginseng (Folia ginseng), Glitter,
Tsuwabuki, deico, gall nuts, duberry "fruit", agar, tencha (green tea), ginger (winter melon), honeysuckle, ginseng (marigold), sugar beet, gooseberry (river cut), corn or corn hair (nanban hair) , Squirrel mochi (sadako), gentian or daffodil (dragon gall), horsetail (tree thief), turmeric (root), horsetail or bean bug or pear vine,
Eucommia ulmoides (bark, leaves, roots), ash (tongue bark), tomatoes, tragacanth, triacanthus "seed", eustoma, dragonfly, troor mallow, corn bean, Nigeria berry "fruits", swordfish (butcher bloom), naginata koju , Nasuna, rapeseed, rapeseed or sword bean (sword bean), Natsumikan, jujube (Otsuki), Naniwaibara (Kinzaiko), Navena (interrupted), peanut (peanut), Nanten (southern nut), Nanbankaramushi (ramie), Odorant, bitternut, bitter wormwood, bitter mugwort, bitternut, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon) or cinnamon (keishi), sycamore, leek
(Nirago), garlic (garlic), nullde (quintet), leek, alder or nebu or nebi or nemur or digokubana
(Fellowship), thistle (Oyagi), Noibaru (Fruit), Nosedine vine (Ryohana), Nogetou, Yarrow, Nodake (pre-hus), Novara, Pineapple "fruits", Hibiscus (Bussouge, Furuin Bussouge, Roselle), Hyalindo, Hyalindo , Pau Doce, Hakamaurabosi (bone fracture supplement), Hakukayumato, Chinese cabbage, Chinese cabbage (tinea bark), Huckleberry "fruits", chickweed (basic), hazel
(Haruko), Hasiridokoro (roth root), basil, lotus (lotus,
Lotus meat, lotus), parsley (netherlands jelly), hadakamugi, batata, bee or madake (boiled bamboo), patchouli, peppermint
(Light load, light load leaf), Mucuna pruriens, Hanasage (Chinese mother), Banana, Hana mint, Hanabishi (Shishishiri, Shishitsuri), Vanilla Bins, Papaya, Hahakogusa (Musk malt grass), Pahalobobo, Hub "whole grass, stem, leaf", paprika , Orchids,
Hamago or Mitsuba Hamago (vine vine), Hamasuge (Kafuzi), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata rubber, haran, pariurus
(European jujube), Parietalia, Harkanran,
Balsamina (pickle, bitter gourd), harunire (invasion, sword-white hide, sword leaf), barbasco, harlin dow, handaikai (seed sea), panoki, cypress (radish), lizard ginseng (participant), pecan nuts, gibana (stone) Garlic, iris flower, higuruma dalia, higotai, hisshi (hishimi), pistachio, beet, hibiscus (stone reed), hibiscus japonica, daisies (daisy), Hinako no Kozuchi (cow knee), chickpeas, cypress, hiba, Castor, sunflower, sunflower (Aoi), himejima (incense stick), Himemu orchid, Pimenta "fruit", juniper beetle, sycamore, sardine "fruit", chickpea, lentil, velordooy, pearl oyster grass (leaf bald, fruit) , Stem ", Betel Nut (Large-sized skin, Renko), Pu'er Tea (Fu-cha), Futokazura (Nantan), butterbur, butterbur款冬 leaves), Eupatorium fortunei (Rankusa), hyacinth bean (扁豆), Fujimodoki
(Chrysanthemum, cherry blossoms), beech, Fuyusuminashikutake mushroom
(Caterpillar), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjeen, Plum "fruit", Frucellaria, Blueberry, Prune, Floral blanka, Blonde psyllium, Bundou (mung bean) ),
Hazelnuts, loofah, hetkaran, safflower, safflower, henken, belladonna, berries "fruit", Persea, Perbianberg, Pereschia grandifolia, Benchisou or duckweed (deceminated), boysenberry "fruits", broomweed or sageweed or nemou or Hahagiki Kochia (Jikinko), Hosairan, Housengka (Fengxen, Acute pup, Bonegrass), Pouteria sapota, Pouteria lucuma, Honoki, Boufu (Windbreak), Spinach, Physalis (Torone), Honoki (Watatsu) Park, Park), bokeh
(Wooden melon), Astragalus mexicanus (Bittersweet), Astragalus vulgaris,
Hosobana Okera (Sokyu), Hosobanokirinso (Kageten Sanchi), Hosobabarengiku, Bodaiju (Bodhi tree), button
(Peony "flower, leaf, bark"), jojoba, Boriji (Rurichisha), Bordeaux, white berry "fruit", Hongonik (Meat Juyo, Daiei), Hongsekkoku (Ironbrush, Suzuyama Ishiha), Maizurten Nansho (Tiannan star), Maou (mahuang), Maca, macadamia nuts, Margaret (Mokshungik), Macri (Aquatic grass), Magnolia sprengueri, Masalanzuba, Masalanzuva de Ceara,
Masheira de Boi, Mashua (Tamanouzenhalen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, pine "leaves, bark, roots", Matta Orho, Matsuhodo (peel flesh), Matico (Cordon sillo), Mayoram (hanahanakka), malvanojadine, mulberry "fruit",
Quince, malein (billot mullein), mango,
Mangosteen, Manzania (Andean chamomile), Manchuria walnut, Mandarin "fruit", Ganoderma lucidum (Ganoderma lucidum), Pheasant (Fructus "Fruit"), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossum), Half-legged beetle Lotus), Misohagi (Cendula vegetable), Mitsugashiwa, Mitsuba, Midorizapote, Midorihakka, Mimosa, Myoga, Miracle fruit "fruit", Myrrh, Mirobalan, Mugiwaraiku, Mukunoki, Mukuruji (extended skin), Munya, Murasaki
(Purple root), murasakisikibu or murasakisikikibu (purple pearl), purple corn, purple fuji wisteria (Kunmei chicken blood wisteria), megakansa opuntica, swordfish (beneficial herb), mebogi, evening primrose (evening grass), melaloca, melissa, meliloto, melon `` `` Fruits '', Mokomogimo, Moso bamboo, Mokugirin, Mojé (pepper), Ilex, Mokko (wood incense), Peach (peaches "leaf, flower, fruit"), Moyashi, Morero cherry "Fruits", Morohaya
(Jump), yakawamurasakiimo, yakchi (maschi), cornflower (cornflower), cornflower, yacon, willow willow, yade (octagon metal plate), mistletoe (willow parasitic), willow
(Kawayanagi, Tachiyanagi, weeping willow, red willow, pussy willow, dog willow, willow, willow, cory willow, unryow willow, willow willow, palm, willow willow, willow, leaf, stem, willow, willow, stem, doro
Yabukouji (purple gold beef), yabutobacco (Tsuruga, Tenmeisei), pokeweed (Shokuryoku), bayberry (Yangmei peel), bayberry, eucalyptus, yucca or flavifolia, yuzu `` fruit '', lily, yoragusa, mugwort (barb leaf), Rygan (Thunder circle), lime "fruit", rye, swingle "fruit", raspberry "leaves, fruit", latania (clamellia), rakkyo or shallot (caucasian white), lavender, longan (dragon eye meat), agave lantern (aono agave lantern, fukurin). Agave), ryokcha (green tea), apple "fruit,
Seed, leaf, root ", gentian, rubus or Suabisimus
(Tsuyo Ryo), Ruritama thistle (Varadigo higotai, Xinjiang stab head), Reishi (Lichie, Lichia nucleus), Lettuce (Chisha), Red currant `` fruit '', Red pitaya, Lemon `` fruit '',
Lemongrass, Forsythia or Forsythia (Forsythia),
Astragalus, Rhizoma, Waxy, Locon, Reed, Rhizoma, Loganberry "Fruit", Rosemary (mannen wax), Rosehip (Novara), Wasabi, Cottonweed (Japanese sage flower), Waremoko (Small ground) Etc.

As the seaweed, there are seaweed [green algae], seaweed [brown algae: giant kelp (Macrocystis pilifera, macrocystis integrifolia, Neocitys ruetokeana)], seaweed [red algae: Tosakanori, Oubatsunomatata] , Tochaka (Yahazu Tsunomata),
Ezotsunomata, Togetsunomata, Hirakotoji, Marubatsunomata, Hirakotoji, Jareusbanori, Kagiousbanori,
Suzius vanori, Haius vanori, Akamomijinori] and the like are typical.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Quanomomimo: Quanonimo, Volvox: Ohigemarawa, Volbox, Palmera, Yotsumemo, Genus Amaiduro: Hisaori, Aomiduro, Tsurugimidoro, Hibimidoro: Hibimidoro, Aosa: Amiosa, Nagaaosa, Kawanori: Kawanori, Furitchera, Shiogusa: Oshiogusa, Asamidoshisa,
Northern lobster, marimo, genus Baronia: Egg Balloonia,
Tamabaronia, Magatagum genus: Magatagum genus, Iwadazu genus: Fusai iwadashi, Surico ivy, Heriwa ivy, Black locust, Hanemo genus, Mil genus: Mill, cromil, Sakibutimir, Nagamill, Hiramil, Kazamizo, Anemone dactylum, Anemone japonicum, Anemone genus , Genus Colecaete, Genus Astragalus, Genus Nymphaea: Narcissus, Genus Astragalus: Astragalus,
Hirohanohitohusa, Usuhitohusa, Motukihitoe,
(Sayamidoro genus, Kunshomu genus, Violet genus: Violet vulgaris, Hoshimidoro genus, Fushinashimidoro genus, etc.)

Cyanobacteria (Suisenzinori genus: Suizenjinori, Aza genus, Nostoc genus: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraela, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Yahagagusa, Ulaboshihaha, Jamigamigusa: Jamigamigusa, Cyprinus genus, Namimacula: Hirnami Makura, Somerakusa: Somerakuna, Nabarimo: Nabarimo, Chasomenia: Nematodactyla: Nematoda: Nascentia: Nematoda: Nashikona, Nasimo , Corydalis:
Black-headed moth, Phytophthora genus: Futomozuku, Ishimozuku genus: Ishimozuku, Kuromo genus: Kuromo, Black-headed moth:
False mozuku, mozuku genus: mozuku, ishige genus: ishige, iroro, ichimegasa genus: ichimegasa, genus genus: keyhole,
Cypresses: Cypresses: Urushigusa: Urushigusa, Kaurisugusa, Tobacco Bug, Genus: Hazelnut, Haberodoki: Haberodoki, Habanori: Habanori, Hazelnut: Blackheaded lobster: Common Blackheaded lobster: Common black lobster: Common black lobster: Common black lobster , Cottonweed, Chishimafukuronori: Chishimafukuronori, Kagomenori: Kagomenori, Muraridori: Murachidori, Shamelessia: Mesogusa, Iwahigenus: Iwahigashi, Nokojimanori: Noriyukinosami, Kayomari
Fennel, genus Tsurumo: genus Tsurumo, genus Anemone: Anata,
Genus Susume, Missing kelp genus: Missing genus kelp, Atsuba Missing genus kelp, kelp genus: Gattara kelp, oyster kelp, Oni konbu, Gohei konbu, Naga konbu, pea kelp, Ochijimi konbu, Tororo konbu genus: Ant locust: Anthoptera scutellaria; , Chromis, Chrysanthemum genus: Chrysanthemum genus, Nestle kelp genus: Nestle kelp, Black locust genus: Kurociome, Neko shikonbu genus: Neko shikonbu,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

Red algae (genus Boschnori: Physcomitrella patens, Funorinousichoke, Genus Amanori: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Axial algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived raw materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degraded products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

[0104] As the material derived from plant or animal raw materials, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, seawater dried matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic Ocean or the Pacific Ocean, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, etc.

(15) Microbial culture metabolites Bacterial metabolites, bacterial extract, fungi or actinomycetes metabolites,
Mold or actinomycete extract, natto metabolite, natto extract, fermented rice extract, fermented rice bran (red bran, white bran),
Trehalose or a derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid fermentation product of legumes, lactic acid fermentation product of coconut genus plant and the like.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside etc.), hydroquinone or its derivative (hydroquinone benzyl ether etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (chamomile, mulberry, gardenia, oleander, mugwort, honeysuckle, yellowfin, pineapple, pearl barley, pearl millet, Hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamamelis, yamawawa, extended life grass, bellflower, oshishi, sequel, irrigation,
Mao, Dokkatsu, Psycho, Bowfish, Hamaboufu, Ogon, Peony, Genshosho, Licorice, quintet,
Showa, safflower, green tea, black tea, Asenyaku) etc.

(21) Melanin dye reducing / decomposing substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover-promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, fermented milk extract, plant extract (Augon, Horsetail, Gentiana, Burdock, Chinese swordfish, Hamamelis, Yokuinin, Odorikosou, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Tachijakosou, Rosemary, Parsley) etc.

(23) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame cultured cells, armature,
Hypericum perforatum, Hamamelis, Clove, Melissa, Trillium birch, Salvia, Rosemary, South Tenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / sterilizing / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Humectant Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its Salt, sodium lactate, mini-sasaniki extract, Bacillus natto metabolite, natto extract, loofah water, birch or red sap.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (sarcophagi, hypericum, clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodilla, button), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castari tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral vascular blood flow enhancer Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, Choji essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, Peruvian balsam essential oil, boad rose essential oil, scented essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable oils such as essential oils and Japanese peppermint oil, and other synthetic flavors.

(43) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, enju dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation products, animal / vegetable polysaccharides and its degradation products, animal / vegetable glycoprotein and its degradation products, blood flow promoters, anti-inflammatory / anti-inflammatory / anti-allergic agents, wound healing agents, Foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorizing / deodorizing agents, etc. can be mentioned. By using them together, the effect of the present invention or other cosmetics It is expected that additive or synergistic improvement of the social effect will be achieved.

Regarding the method of addition to the melanin production inhibitor, fibroblast proliferation promoter or cosmetic composition of the present invention, it may be added in advance or may be added during the production, and the workability is improved. Therefore, it may be selected as appropriate.

[0137]

EXAMPLES Hereinafter, production examples, test examples and prescription examples will be described, but the present invention is not limited thereto.

(Production Example 1) Aloe vera, almonds, enokitake, eringii, sesame, sanyaku, shiitake, shimeji, dandelion, elderberry, senkyu, senburi, sokuhaku, tsukuritake, capsicum,
Touki, Tounin, Dokudami, Nameko, Carrot, Bakumondou, Agaricus, Himematsutake, Maitake, Mukuge, Yukuinin, Oyaku, Oolong Tea, Olive, Cuckoo, Kawamura Mugwort, Quercus cyprinus, Clara, Steller's vulgaris, Rhubarb, Soybean, Clove, Ginkgo biloba, Stinkweed , 100g of dried plants such as button, hops, willow, yasha and yukinoshita are heated and extracted with purified water (about 80 ° C) for about 5 hours and filtered to extract (dry solids:
About 0.1-2.5%) to obtain about 1.0 kg.

(Production Example 2) Aloe vera, almond, enokitake, eringii, sesame, sanyaku, shiitake, shimeji, dandelion, elderberry, senkyu, senburi, sokuhaku, tsukuritake, capsicum,
Touki, Tounin, Dokudami, Nameko, Carrot, Bakumondou, Agaricus, Himematsutake, Maitake, Mukuge, Yukuinin, Oyaku, Oolong Tea, Olive, Cuckoo, Kawamura Mugwort, Quercus cyprinus, Clara, Steller's vulgaris, Rhubarb, Soybean, Clove, Ginkgo biloba, Stinkweed , 100 g of dried plants such as button, hops, willow, yasha and yukinoshita are soaked in 50% ethanol solution, extracted at room temperature for 5 days, and then filtered to obtain an extract (dry solid content: about 0.1 to 2.5%). You get about 1.0 kg.

(Production Example 3) 100 g of dried seaweed dried seaweed of Chlorella, Aonori, Anahusa, Sea Urchin, Kirinsai, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hiba Mata, and Seaweed was purified water (about 80 ° C.). Extract by heating for 5 hours, filter and extract (dry solids: approx.
0.5-3.0%) yields about 1.0-3.0 kg.

(Production Example 4) 100 g of each dried seaweed seaweed of Chlorella, Aonori, Anahusa, Sea Urchin, Kirinsai, Kotoji Tsunomata, Kombu, Aquilegia, Astragalus, Hijiki, Hijirimen, Hiba Mata, and Seaweed was immersed in a 50% ethanol solution and allowed to stand at room temperature. After extracting for 5 days and night, it is filtered to obtain about 1.0-3.0 kg of extract (dry solid content: about 0.6-2.0%).

Production Example 5 To 15 g of water-soluble (carboxymethylated) β-1,3-glucan paramylon, 200 mL of 40% sodium hydroxide aqueous solution and 40 mL of isopropyl alcohol were added, and crushed with ice 5
00 g was gradually added to obtain a solution. 0-5 in an ice bath
A sodium monochloroacetate (corresponding to 120 to 150 g) solution was gradually added while the temperature was kept at 0 ° C., and the reaction was carried out for 3 to 5 hours. After further stirring at room temperature to 50 ° C for about 5 to 15 hours, the mixture is filtered, and the filtrate is transferred to a dialysis membrane.
It was dialyzed for a day. Then, this was freeze-dried to obtain about 15 g of water-soluble hydroxyalkylated β-1,3-glucan (degree of substitution: about 0.44 / per unit sugar).

(Production Example 6) Yeast extract 500 g of baker's yeast (Sacharomyces cerevisiae) was dispersed in ten times the amount of purified water, and self-digested at about 37 ° C for 48 hours.
This solution was filtered, and a small amount of anhydrous ethanol was added to the obtained filtrate to obtain about 4 kg of yeast extract.

(Production Example 7) Whey raw material (aqueous solution of milk protein or skim milk powder and glucose)
30 L of lactic acid bacterium is inoculated with 1% and cultured at 40 ° C. for 3 days to prepare fermented milk, which is sterilized and filtered to obtain about 24 L whey.

Commercially available products such as N-acetyltyrosine (manufactured by Nippon Rikagaku Co., Ltd.) and their derivatives (N-acetyltyrosine sodium, N-acetyltyrosine potassium) and the like can be used. good.

(Test 1) Melanin production inhibitory action test The present inventors decided to evaluate the melanin production inhibitory action based on B16 melanoma cells.

[Test Method and Evaluation Method] B16 melanoma cells pre-cultured for 24 hours are transferred to a fresh medium, to which 0.5% of the sample is added and cultured for 3 days. Then, the cultured cells are treated with trypsin, heated and dissolved in a 1N-NaOH, 10% DMSO solution, and the absorbance at 420 nm is measured. Distilled water was used as a blank instead of the sample, and cells to which the sample was added at the same time were subjected to the MTT reduction method (Tim Mosmann; Journ).
The activity was measured by al of Immunological Methods p55-63 (1983)), and the MTT reducing activity of the sample-loaded cells was calculated with the MTT reducing activity of the blank cells as 1 unit.
The melanin amount of the sample was calculated as the absorbance / MTT reducing activity (1 unit), and the inhibition rate (%) with respect to the melanin production amount of blank cells was calculated by the following formula (Equation 1). The results are shown in Tables 1 to 4. It was “Sample” The sample of the melanin production inhibitory action test was the extract obtained in Production Examples 2 and 4 of the present invention (solid content concentration: 0.5
%), Water-soluble β-1,3-glucan of Production Examples 5 to 7, yeast extract, whey or commercially available N-acetyltyrosine dissolved in purified water (solid content concentration 0.5%) (however, ,
When two or more essential components of the present invention were used in combination, the same concentration of each component was added and prepared so that the solid content concentration became 0.5%) and used for the test. As a comparative sample, kojic acid (manufactured by Sigma) was prepared under the same conditions and used for the test.

<Equation 1> Melanin production inhibition rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100

[0149]

[Table 1]

[0150]

[Table 2]

[0151]

[Table 3]

[0152]

[Table 4]

(Test Results) As shown in Tables 1 to 4, (A) component of the present invention: aloe vera extract, chlorella extract, yeast extract, and (B) component: oyster, oolong tea, olive, cuckoo, wormwood mugwort. , One or more kinds of plant extracts selected from, linden, clara, horse chestnut, rhubarb, soybean, soybean, clove, ginkgo, tormentilla, grape, button, hop, willow, yasha, yukinoshita, or whey, N-acetyltyrosine or its One or more selected from derivatives, or Aonori, Anahosa,
Those containing a combination of one or more kinds of seaweed extracts selected from sea urchin, giraffe, kotoji tsunomata, kelp, horse mackerel, agar tree, hijiki, hijirimen, hiba mata, and wakame have significantly suppressed the formation of melanin pigment and have high melanin. It was confirmed to have a production suppressing action.
Also, when compared to kojic acid or various components of the present invention alone,
It was confirmed that it has a melanin production inhibitory effect that is almost equal or higher, and can be used as a melanin inhibitor. Other (A) ingredients: almond, enoki mushroom,
Eringii, sesame, sanyaku, shiitake, shimeji mushroom, dandelion, elderberry, senkyu, senburi, sokuhaku, tsukuritake, capsicum, touki, tounin, dokudami, nameko, carrot, bakumondou,
One or more kinds of plant extracts selected from agaricus, Himematsutake, maitake mushrooms, starfish, and yokuinin, or water-soluble β-
One or more selected from 1,3-glucan derivatives (B)
Ingredients: oyster, oolong tea, olive, cuckoo, wormwood, linden, clara, holly cypress, rhubarb, soybean, cloves, clover, turmentilla,
One or more plant extracts selected from grapes, buttons, hops, willow trees, yashas, and Yukinoshita, or whey, N
-A combination of one or more kinds selected from acetyltyrosine or a derivative thereof, or one or more kinds of seaweed extracts selected from Aonori, Anahusa, Sea Urchin, Ginkgo cypress, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hibamata and Wakame. As a result, it was found that those containing the same had a melanin production inhibitory effect which was almost the same as or higher than that of kojic acid or the various components of the present invention alone.

(Test 2) Fibroblast Proliferation Promotion Test The present inventor used the MTT based on normal skin fibroblasts.
The reduction method was used to test and evaluate the cell growth promoting action.

[Test Method] The MTT reduction method is a cytotoxicity and cell activation evaluation method (rapid color quantification of growing and viable cells: Tim Mosmann; Journal of Immunological Met).
hods p55-63 (1983) reference), MTT (3- (4,
5-dimethyl-2-thiazolyl) -2,5-diphenyltetrazolium br
omide) is taken up by cells, reduced and cleaved by NADH present in intracellular mitochondria, and utilizes the property of producing water-insoluble blue formazan.This blue formazan is dissolved in acidic isopropanol and its absorbance is measured. It is something to measure.

[Preparation of test] The present inventor also examined the FBS (fetal bovine serum) concentration at which cells did not proliferate or decrease in advance, and the cells were cultured in a MEM medium containing 0.5% FBS (fetal bovine serum). It was confirmed that the conditions were satisfied, and the serum concentration of the test medium was adjusted to 0.5%, and it was decided that the fibroblast proliferation promoting action of the test sample alone could be quantitatively evaluated.

[Measurement of fibroblast proliferation promoting action] 5% F
Human skin fibroblasts (NB1RGB purchased from RIKEN Gene Bank / Cell Development Bank) were used in MEM medium containing BS (fetal bovine serum) at a density of 5 × 10 ³ cells / well and 96 wells p.
It was dispensed late, and cultured under the conditions of 5% CO ₂ and 37 ° C. for 24 hours. Then, the sample was replaced with a MEM medium containing 0.5% FBS to which samples of various concentrations (Production Example 1: various plant extracts) were added. At this time, 0.5% FBS-containing MEM medium containing no sample was used as a blank, and the culture was continued for 9 days in a CO ₂ incubator while exchanging with the same medium every 3 days.
The cells of the sample addition group relative to the blank were measured by the T reduction method. "Evaluation method of fibroblast proliferation promoting action" The obtained results were evaluated according to the following criteria, and the results are shown in Tables 5 to 8. As the fibroblast proliferation promoting action, strongly cell-proliferated one was +++, cell-proliferated one was ++, slightly cell-proliferated one was +, no cell-proliferated one was +, and cell decreased one was −. "Sample" The sample of the fibroblast proliferation promoting action test is the extract obtained in Production Examples 1 and 3 of the present invention (solid content: 0.
(Adjusted to 5%), water-soluble β-1,3-glucan of Production Examples 5 to 7, yeast extract, whey or commercially available N-acetyltyrosine dissolved in purified water (solid content concentration 0.5%) ( However, when two or more essential components of the present invention were used in combination, the same concentration of each component was added and prepared so that the solid content concentration was 0.5%), and subjected to the test.

[0158]

[Table 5]

[0159]

[Table 6]

[0160]

[Table 7]

[0161]

[Table 8]

(Test Results) As shown in Tables 5 to 8, (A) of the present invention: aloe vera extract, chlorella extract, yeast extract, and (B): oyster, oolong tea, olive, cuckoo, wormwood, linden tree. , One or more kinds of plant extracts selected from, Clara, Vaccinium vulgaris, Rheum palmatum, Soybean, Clove, Tsurugudami, Tormentilla, Grape, Button, Hops, Willow, Yasha, Yukinoshita,
Or one or more kinds selected from whey, N-acetyltyrosine or a derivative thereof, or Aonori, Anahosa, Sea Urchin, Kirinsai, Kotoji Tsunomata, kelp, Sugi Nori,
It was confirmed that those containing a combination of one or more kinds of seaweed extract selected from Tengusa, Hijiki, Hijirimen, Hiba Mata, and Wakame had a strong fibroblast proliferation promoting action. It has been confirmed that the various components of the present invention have substantially the same or higher fibroblast proliferation-promoting action as compared with the individual components, and can be used as a fibroblast proliferation-promoting agent.
Other (A) ingredients: almond, enokitake, eringii, sesame, sanyaku, shiitake, shimeji mushroom, dandelion, elderberry, senkyu, assembly,
One or more plant extracts selected from Sohakuhi, Tsukuritake, Capsicum, Toki, Tounin, Dodami, Nameko, Carrot, Bakumondou, Haratake, Himematsutake, Maitake, Mukuge, Yokuinin, or water-soluble β-1,
At least one selected from 3-glucan derivatives (B) component: oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, holly vine, rhubarb, soybean, clove, turdula, tormentilla,
One or more plant extracts selected from grapes, buttons, hops, willow trees, yashas, and Yukinoshita, or whey, N
-A combination of one or more kinds selected from acetyltyrosine or a derivative thereof, or one or more kinds of seaweed extracts selected from Aonori, Anahusa, Sea Urchin, Ginkgo cypress, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hibamata and Wakame. As a result, it was also possible to obtain a result in which even those containing the same have a fibroblast proliferation-promoting action which is almost equal to or higher than that of the various components of the present invention alone.

(Test 3) Safety test (1) Primary skin irritation test Plants, seaweed extracts, water-soluble β-1,3-glucan derivatives, yeast extracts obtained in Production Examples 1 to 7, Whey or commercially available N-acetyltyrosine has a dry solids concentration of about 0.
It was prepared with purified water to 5% and applied to the skin of Japanese white rabbits (female, 1 group, 3 animals, body weight around 2.3 kg) with shaved back. Evaluation was carried out 24, 48, and 72 hours after application using erythema and edema as indices based on the Draize criterion.
As a result, no erythema or edema was observed in any of the animals, and it was judged that there was no problem with respect to primary skin irritation.

(Test 4) Safety test (2) Skin cumulative irritation test Similarly, each plant / each seaweed extract obtained in Production Examples 1 to 7,
Prepare water-soluble β-1,3-glucan derivative, yeast extract, whey, or commercially available N-acetyltyrosine with purified water to a dry solid concentration of about 0.5%, and shave the back Hartley guinea pig (female, 1 group 3 animals, weight
About 320 g) was applied to the skin once a day, 5 times a week, at 0.5 mL / animal. Application was carried out for 2 weeks and shaving was carried out on the last application day of each week. On the day after each application day and the day after the last application day, evaluation was performed using erythema and edema as indexes based on the Draize criterion. As a result, it was judged that no erythema and edema were observed in any of the animals for 2 weeks, and that there was no problem regarding cumulative skin irritation.

(Test 5) Safety test (3) Single dose toxicity test Each plant / each seaweed extract obtained in Production Examples 1 to 7, water-soluble β-1,3-glucan derivative, yeast extract, Whey or commercially available N-acetyltyrosine was adjusted with purified water to a concentration of 12.5%, and a volume of 16 mL / kg per animal before the test,
Ddy mice (male and female, 1 group 5) fasted for 4 hours
Orally administered to a mouse (5 weeks old), and the onset and degree of toxicity symptoms were observed over time. As a result, in all mice, 14
No abnormalities were observed during the day, and the results of autopsy were also normal. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined to be a safe substance.

(Formulation Example) Production of Melanin Inhibitor, Fibroblast Growth Promoter, Cosmetic Composition According to the above-mentioned evaluation results, the formulation examples are shown below. It may be produced by the method, and only the blending amount is shown. Further, the present invention is not limited to these.

[0167] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Jojoba oil 5.0     3. Cetyl alcohol 1.5     4. Glycerin monostearate 2.0     5. Polyoxyethylene (20) cetyl ether 3.0     6. Polyoxyethylene (20) soorbitan monooleate 2.0     7.1,3-butylene glycol 1.0     8. Glycerin 2.0     9. A-1: Aloe vera extract of Production Example 2       A-2: Almond extract of Production Example 2       A-3: Enokitake mushroom extract of Production Example 2       A-4: Eringii extract of Production Example 2       A-5: Sesame extract of Production Example 2       A-6: Sanyaku extract of Production Example 2       A-7: Shiitake extract of Production Example 2       A-8: Shimeji extract of Production Example 2       A-9: A dandelion extract of Production Example 2       A-10: Sambucus nigra extract of Production Example 2       A-11: Senkyu extract of Production Example 2       A-12: Assembly extract of Production Example 2       A-13: Sophoraceae extract of Production Example 2       A-14: Tsukuritake Extract of Production Example 2       A-15: Capsicum extract of Production Example 2       A-16: Touki extract of Production Example 2       A-17: Tonin extract of Production Example 2       A-18: Dokudami extract of Production Example 2       A-19: Nameko extract of Production Example 2       A-20: Carrot extract of Production Example 2       A-21: Bakumondou extract of Production Example 2       A-22: Agaricus extract of Production Example 2       A-23: Himematsutake Extract of Production Example 2       A-24: Maitake extract of Production Example 2       A-25: Mukge extract of Production Example 2       A-26: Yokuinin extract of Production Example 2       A-27: Chlorella extract of Production Example 4       A-28: Yeast extract of Production Example 6       A-29: Water-soluble β-1,3-glucan of Production Example 5       * Any one of A-1 to A-29 extract 5.0    10.B-1: Peony extract of Production Example 2       B-2: Oolong tea extract of Production Example 2       B-3: Olive extract of Production Example 2       B-4: Cuckon extract of Production Example 2       B-5: Kawamura Artemisia extract of Production Example 2       B-6: Ginseng extract of Production Example 2       B-7: Clara extract of Production Example 2       B-8: Horse chestnut extract of Production Example 2       B-9: Rheum palmatum extract of Production Example 2       B-10: Soybean extract of Production Example 2       B-11: Clove extract of Production Example 2       B-12: Tsudukudami extract of Production Example 2       B-13: Tormentilla extract of Production Example 2       B-14: Grape extract of Production Example 2       B-15: Button extract of Production Example 2       B-16: Hop extract of Production Example 2       B-17: Michiyanagi extract of Production Example 2       B-18: Yasha extract of Production Example 2       B-19: Yukinoshita extract of Production Example 2       B-20: Whey of Production Example 7       B-21: Commercially available N-acetyltyrosine solution       B-22: Aonori Extract of Production Example 4       B-23: Ananaosa Extract of Production Example 4       B-24: Sea urchin extract of Production Example 4       B-25: Ginkgo biloba extract of Production Example 4       B-26: Kotoji Tsunomata extract of Production Example 4       B-27: Laminaria extract of Production Example 4       B-28: Sugi Nori extract of Production Example 4       B-29: Agar-agar extract of Production Example 4       B-30: Hijiki extract of Production Example 4       B-31: Hijirimen extract of Production Example 4       B-32: Hiba Mata Extract of Production Example 4       B-33: Seaweed extract of Production Example 4       * Extract from one of B-1 to B-33 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0168] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,2-Pentanediol 1.0    11. Glycerin 2.0    12. Almond extract from Production Example 2 3.0    13. Soybean Extract from Production Example 2 3.0    14. Pig placenta water extract 1.0    15. Preservative (paraoxybenzoate) Suitable amount    16. Residue to make purified water 100

[0169] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 10.0     4. Isopropyl palmitate 10.0     5. Olive oil 1.0     6. Shea butter 1.0     7. Butylhydroxyanisole 0.1     8. Vitamin E derivative 0.1     9. Aloe vera extract of Production Example 2 3.0    10. Sanyak extract of Production Example 2 3.0    11. Tormentilla Extract 3.0 of Production Example 2    12. Button Extract 3.0 from Production Example 2    13. Grapefruit fruit or leaf hot water extract 1.0    14. Preservative (benzalkonium chloride) Suitable amount    15. Perfume (musk water) Suitable amount    16. Residue to make purified water 100

[0170] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Eringii fruiting body 30% ethanol extract 1.0     6. Shimeji fruit body 30% ethanol extract 1.0     7. Umiuchiwa 30% ethanol extract 1.0     8. Polygonum heterophyllum whole plant 30% ethanol extract 1.0     9. Grapefruit fruit or leaf 50% ethanol extract 1.0    10. Kiwi fruit 50% ethanol extract 1.0    11. White birch sap 1.0    12. Antibacterial / antiseptic (lactoferrin solution)    13. Perfume (Western light water) Suitable amount    14. Purified water 100 residue

[0171] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4. Aloe vera stem or leaf 50% 1,3-butylene glycol extract 2.0     5. Whole assembly 50% 1,3-butylene glycol extract 2.0     6. Yeast 50% 1,3-butylene glycol extract 2.0     7. Uyaku rhizome 50% 1,3-butylene glycol extract 2.0     8. Yasha fruit or peel 50% 1,3-butylene glycol extract 2.0     9. Hibamata 50% 1,3-butylene glycol extract 2.0    10. Allium grass 50% 1,3-butylene glycol extract 2.0    11. Gentian whole plant 50% ethanol extract 1.0    12. Sage whole plant 50% ethanol extract 1.0    13. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0    14. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0    15. Allantoin 0.2    16. Astringent (zinc sulfocarbonate) 0.2    17. Antibacterial / preservative (thiamin lauryl sulfate)    18. Perfume (lavender water) Suitable amount    19. Residue to make purified water 100

[0172] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Solbit 1.0     4. Ethanol 15.0     5. Enokitake fruiting body or mycelium 30% ethanol extract 2.0     6. Shiitake fruiting body or mycelium 30% ethanol extract 2.0     7. Tsukuritake fruiting body or mycelium 30% ethanol extract 2.0     8. Clara root or rhizome 30% glycerin extract 2.0     9. Rhizoma root or rhizome 30% glycerin extract 1.0    10. Whole hawthorn grass 30% glycerin extract 1.0    11. Ascorbic acid 0.2    12. Astringent (calamine) 0.1    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (apple water) Appropriate amount    15. Residue to make purified water 100

[0173] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3.1,2-Pentanediol 1.0     4. Ethanol 15.0     5. Iron oxide (red iron) 0.2     6. Zinc oxide 0.5     7. Kaolin 2.0     8. Sesame seed 50% propylene glycol extract 2.0     9. All dandelion 50% propylene glycol extract 2.0    10. Carrot rhizome 50% propylene glycol extract 2.0    11. Chlorella 50% propylene glycol extract 2.0    12. Oolong tea leaf or branch leaf 50% propylene glycol extract 2.0    13. Pleurotus cornucopia rhizome or root bark 50% propylene glycol extract 2.0    14. Button root or rhizome 50% propylene glycol extract 2.0    15. Panax ginseng root 50% propylene glycol extract 1.0    16. Porcine placenta enzyme decomposition solution 1.0    17. Camphor 0.2    18. Phenol 0.03    19. Preservative (photosensitive element 201 & 401) Suitable amount    20. Perfume (bodhi tree water) appropriate amount    21. Residue to make purified water 100

[0174] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 15.0     5. Aloe vera stem or leaf 50% glycerin extract 1.0     6. Chlorella 50% glycerin extract 1.0     7. Kakon root 50% glycerin extract 1.0     8. Soybean seed 50% glycerin extract 1.0     9. Preservative (paraoxybenzoate) Suitable amount    10. Perfume (Ylang-Ylang essential oil) Suitable amount    11. Residue to make purified water 100

[0175] (Prescription example 9) Peel-off pack mass%     1. Glycerin 6.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 10.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Collagen protein enzymatic degradation solution 3.0     8. Sambucus nigra fruit or flower 50% ethanol extract 2.0     9. Senkyu rhizome 50% ethanol extract 2.0    10. Hop fruit or female flower 50% ethanol extract 2.0    11. Eucalyptus leaf or stem 30% ethanol extract 2.0    12. Trehalose solution 1.0    13. Preservative (paraoxybenzoate) Suitable amount    14. Perfume (Chamomile water) Suitable amount    15. Residue to make purified water 100

[0176] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Chamomile oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8. Tonin extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)     9. Bakmondou Extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. Yukinoshita extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    12. Yuzu fruit extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    13. Liquid shea butter 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Preservative (acrinol) 0.1    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0177] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 5.0     9.1,2-Pentanediol 2.0    10. Boiled dandelion whole plant hot water extract 3.0    11. Dokudami whole plant hot water extract 3.0    12. Tormentilla root or rhizome hot water extract 3.0    13. Rosemary leaf or flower hot water extract 2.0    14. Shiso leaf 50% propylene glycol extract 2.0    15. Purple roots 50% propylene glycol extract 2.0    16. Soybean seed fermented soybeans 1.0    17. Glycyrrhetinic acid 0.1    18. Pig placenta enzyme digestion solution 0.5    19. Preservative (paraben) proper amount    20. Perfume (apple water)    21. Residue to make purified water 100

[0178] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 15.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7.A-1: Aloe vera extract of Production Example 2       A-2: Almond extract of Production Example 2       A-3: Enokitake mushroom extract of Production Example 2       A-4: Eringii extract of Production Example 2       A-5: Sesame extract of Production Example 2       A-6: Sanyaku extract of Production Example 2       A-7: Shiitake extract of Production Example 2       A-8: Shimeji extract of Production Example 2       A-9: A dandelion extract of Production Example 2       A-10: Sambucus nigra extract of Production Example 2       A-11: Senkyu extract of Production Example 2       A-12: Assembly extract of Production Example 2       A-13: Sophoraceae extract of Production Example 2       A-14: Tsukuritake Extract of Production Example 2       A-15: Capsicum extract of Production Example 2       A-16: Touki extract of Production Example 2       A-17: Tonin extract of Production Example 2       A-18: Dokudami extract of Production Example 2       A-19: Nameko extract of Production Example 2       A-20: Carrot extract of Production Example 2       A-21: Bakumondou extract of Production Example 2       A-22: Agaricus extract of Production Example 2       A-23: Himematsutake Extract of Production Example 2       A-24: Maitake extract of Production Example 2       A-25: Mukge extract of Production Example 2       A-26: Yokuinin extract of Production Example 2       A-27: Chlorella extract of Production Example 4       A-28: Yeast extract of Production Example 6       A-29: Water-soluble β-1,3-glucan of Production Example 5       * Extract from one of A-1 to A-29 3.0     8.B-1: Peony extract of Production Example 2       B-2: Oolong tea extract of Production Example 2       B-3: Olive extract of Production Example 2       B-4: Cuckon extract of Production Example 2       B-5: Kawamura Artemisia extract of Production Example 2       B-6: Ginseng extract of Production Example 2       B-7: Clara extract of Production Example 2       B-8: Horse chestnut extract of Production Example 2       B-9: Rheum palmatum extract of Production Example 2       B-10: Soybean extract of Production Example 2       B-11: Clove extract of Production Example 2       B-12: Tsudukudami extract of Production Example 2       B-13: Tormentilla extract of Production Example 2       B-14: Grape extract of Production Example 2       B-15: Button extract of Production Example 2       B-16: Hop extract of Production Example 2       B-17: Michiyanagi extract of Production Example 2       B-18: Yasha extract of Production Example 2       B-19: Yukinoshita extract of Production Example 2       B-20: Whey of Production Example 7       B-21: Commercially available N-acetyltyrosine solution       B-22: Aonori Extract of Production Example 4       B-23: Ananaosa Extract of Production Example 4       B-24: Sea urchin extract of Production Example 4       B-25: Ginkgo biloba extract of Production Example 4       B-26: Kotoji Tsunomata extract of Production Example 4       B-27: Laminaria extract of Production Example 4       B-28: Sugi Nori extract of Production Example 4       B-29: Agar-agar extract of Production Example 4       B-30: Hijiki extract of Production Example 4       B-31: Hijirimen extract of Production Example 4       B-32: Hiba Mata Extract of Production Example 4       B-33: Seaweed extract of Production Example 4       * Any one of B-1 to B-33 extract 3.0     9. Loofah fruit or stem 50% 1,3-butylene glycol extract 2.0    10. Dipotassium glycyrrhetinate 1.0    11. Apricot kernel 0.1    12. Preservative (salicylic acid) 0.1    13. Perfume (orange water) Suitable amount    14. Purified water 100 residue

[0179] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 15.0     2. Palmitic acid 15.0     3. Myristic acid 15.0     4. Lauric acid 4.0     5. Oleyl alcohol 1.5     6. Lanolin derivative (EO adduct) 1.0     7. Glycerin 18.0     8. Potassium hydroxide 6.0     9.A: Aloe vera leaf or stem 50% 1,3-butylene glycol extract       B: Almond seed 50% 1,3-butylene glycol extract       C: Whole plant 50% 1,3-butylene glycol extract       * Any one of A to C extract 5.0    10.D: 50% oolong tea leaves or branch leaves 1,3-butylene glycol extract       E: 50% 1,3-butylene glycol extract of rhubarb root or rhizome       F: Soybean seed 50% 1,3-butylene glycol extract       G: Grape leaf or fruit 50% 1,3-butylene glycol extract       * Any one of D to G extract 5.0    11. Cornflower 50% diglycerin extract 2.0    12. Peach leaf hot water extract 2.0    13. Safflower whole plant 50% ethanol extract 2.0    14. Glycyrrhetinic acid 1.0    15. Preservative (salicylic acid) 0.1    16. Perfume (Mugwort water)    17. Residue to make purified water 100

[0180] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Himematsutake 70% 1,3-butylene glycol extract 1.0     5. Yeast extract of Production Example 6 1.0     6. Seaweed 70% 1,3-butylene glycol extract 0.5     7. Whey of Production Example 7 1.5     8. Army cucumber leaf or stem 70% 1,3-butylene glycol extract 0.5     9. Loquat leaf 70% 1,3-butylene glycol extract 1.5    10. Polyethylene powder 0.5    11. Hydroxypropyl chitosan solution 0.5    12. Amino acids (glycine, glutamine, etc.) 0.5    13. Preservative (undecylenic acid, phenol) Suitable amount    14. pH adjusting agent    15. Perfume (lavender water) Suitable amount    16. Residue to make purified water 100

[0181] (Prescription example 15) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3. Squalane 10.0     4. Vaseline 5.0     5. Stearyl alcohol 3.0     6. Stearic acid 3.0     7. Glyceryl monostearate 2.0     8. Polyethyl acrylate 1.0     9.1,3-butylene glycol 6.0    10. Disodium edetate 0.1    11. Triethanolamine 1.0    12. Titanium dioxide 5.0    13. Water-soluble β-1,3-glucan of Production Example 5 0.5    14. N-acetyl tyrosine solution 0.5    15. Honeysuckle whole plant 50% dipropylene glycol extract 0.5    16. Mulberry peel 50% dipropylene glycol extract 0.5    17. Purple root 50% dipropylene glycol extract 0.5    18. Hypericum perforatum dipropylene glycol extract 1.5    19. Root root 50% dipropylene glycol extract 1.5    20. Preservative (benzyl paraoxybenzoate) Suitable amount    21. Fragrance (jasmine water) Suitable amount    22. Residue of purified water 100

[0182] (Prescription example 16) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 65.0     2. Ethyl paraaminobenzoate 1.0     3. Tetrahydroxybenzophenone 1.0     4. Cetyl octanoate 20.0     5. Pepper fruit 30% 1,3-butylene glycol extract 1.0     6. Touki rhizome 10% 1,3-butylene glycol extract 1.0     7. Centipede fruit or leaf 50% 1,3-butylene glycol extract 0.5     8. Yukinoshita whole plant 30% 1,3-butylene glycol extract 0.5     9. Rakanka fruit or pericarp hot water extract 3.0    10. Sancha flower whole plant hot water extract 0.5    11. Peony root or leaf hot water extract 0.5    12. Dihydroxymethoxybenzophenone 0.2    13. Antioxidant (Butylhydroxytoluene) Suitable amount    14. Perfume (cornflower water) Suitable amount

[0183] (Prescription example 17) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Aloe vera leaf or stem hot water extract dry powder 1.0    16. Kakon root or rhizome Hot water extraction dry powder 1.0    17. Safflower whole plant 50% ethanol extract 0.5    18. Arnica flower or leaf 30% ethanol extract 0.5    19. Liquid shea butter 0.5    20. Centella asiatica leaf or stem 50% ethylene glycol extract dry powder 0.5    21. Tomato fruit 50% ethylene glycol extract dry powder 0.3    22.Wenzhou mandarin orange peel or fruit hot water extract dry powder 0.3    23. Mackerel fruit 30% butanol extract 0.3    24. Preservative (phenoxyethanol) 0.1    25. Perfume (Rose water)    26. Residue to make purified water 100

[0184] (Prescription example 18) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6. Himematsutake fruiting body 20% 2,3-butylene glycol extract 2.0     7. Yeast hot water extract 2.0     8. Grape leaf or fruit 30% 1,4-butylene glycol extract 2.0     9. Kotoji Tsunomata 30% 1,4-butylene glycol extract 1.0    10. Hamamelis bark hot water extract 2.0    11. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    12. Hydroxypropyl chitosan solution 2.0    13. Mucopolysaccharide solution 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (photosensitive element 101)    16. pH adjuster    17. Perfume (sandalwood water)    18. Residue to make purified water 100

[0185] (Prescription example 19) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6.A-1: Aloe vera extract of Production Example 2       A-2: Almond extract of Production Example 2       A-3: Enokitake mushroom extract of Production Example 2       A-4: Eringii extract of Production Example 2       A-5: Sesame extract of Production Example 2       A-6: Sanyaku extract of Production Example 2       A-7: Shiitake extract of Production Example 2       A-8: Shimeji extract of Production Example 2       A-9: A dandelion extract of Production Example 2       A-10: Sambucus nigra extract of Production Example 2       A-11: Senkyu extract of Production Example 2       A-12: Assembly extract of Production Example 2       A-13: Sophoraceae extract of Production Example 2       A-14: Tsukuritake Extract of Production Example 2       A-15: Capsicum extract of Production Example 2       A-16: Touki extract of Production Example 2       A-17: Tonin extract of Production Example 2       A-18: Dokudami extract of Production Example 2       A-19: Nameko extract of Production Example 2       A-20: Carrot extract of Production Example 2       A-21: Bakumondou extract of Production Example 2       A-22: Agaricus extract of Production Example 2       A-23: Himematsutake Extract of Production Example 2       A-24: Maitake extract of Production Example 2       A-25: Mukge extract of Production Example 2       A-26: Yokuinin extract of Production Example 2       A-27: Chlorella extract of Production Example 4       A-28: Yeast extract of Production Example 6       A-29: Water-soluble β-1,3-glucan of Production Example 5       * Any one of A-1 to A-29 extract 5.0     7. B-1: Peony extract of Production Example 2       B-2: Oolong tea extract of Production Example 2       B-3: Olive extract of Production Example 2       B-4: Cuckon extract of Production Example 2       B-5: Kawamura Artemisia extract of Production Example 2       B-6: Ginseng extract of Production Example 2       B-7: Clara extract of Production Example 2       B-8: Horse chestnut extract of Production Example 2       B-9: Rheum palmatum extract of Production Example 2       B-10: Soybean extract of Production Example 2       B-11: Clove extract of Production Example 2       B-12: Tsudukudami extract of Production Example 2       B-13: Tormentilla extract of Production Example 2       B-14: Grape extract of Production Example 2       B-15: Button extract of Production Example 2       B-16: Hop extract of Production Example 2       B-17: Michiyanagi extract of Production Example 2       B-18: Yasha extract of Production Example 2       B-19: Yukinoshita extract of Production Example 2       B-20: Whey of Production Example 7       B-21: Commercially available N-acetyltyrosine solution       B-22: Aonori Extract of Production Example 4       B-23: Ananaosa Extract of Production Example 4       B-24: Sea urchin extract of Production Example 4       B-25: Ginkgo biloba extract of Production Example 4       B-26: Kotoji Tsunomata extract of Production Example 4       B-27: Laminaria extract of Production Example 4       B-28: Sugi Nori extract of Production Example 4       B-29: Agar-agar extract of Production Example 4       B-30: Hijiki extract of Production Example 4       B-31: Hijirimen extract of Production Example 4       B-32: Hiba Mata Extract of Production Example 4       B-33: Seaweed extract of Production Example 4       * Extract from one of B-1 to B-33 5.0     8. Astragalus leaf 50% 2,3-butylene glycol extract 2.0     9. Mackerel fruit 30% 1,2-butylene glycol extract 2.0    10. Scented flower 50% 1,3-butylene glycol extract 1.0    11. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    12. Hydroxyethyl chitosan solution 1.0    13. Trehalose solution 1.0    15. Hydrolyzed silk solution 1.0    16. Perfume (jasmine water) Suitable amount    17. Residue to make purified water 100

[0186] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6.A: Agaricus fruit body 50% 1,3-butylene glycol extract       B: Himematsutake fruiting body 50% 1,3-butylene glycol extract       C: 50% 1,3-butylene glycol extract of sage fruit or flower       D: Yokuinin seed 50% 1,3-butylene glycol extract       * A decomposition liquid of any one of A to D 3.0     7.E: Soybean seed 50% 1,3-butylene glycol extract       F: 50% 1,3-butylene glycol extract of Rhododendron or rhizome       G: Tormentilla root or rhizome 50% 1,3-butylene glycol extract       H: Yukinoshita whole plant 50% 1,3-butylene glycol extract       * Any one of E to H decomposition solution 3.0     8. Trehalose solution 1.0     9. Hydrolyzed keratin solution 1.0    10. Antibacterial / antiseptic (benzalkonium chloride)    11. Fragrance (chamomile water) Suitable amount    12. Residue to make purified water 100

[0187]  (Formulation example 21) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.A: Aratake fruiting body 50% 1,3-butylene glycol extract       B: Himematsutake fruiting body 50% 1,3-butylene glycol extract       C: 50% 1,3-butylene glycol extract of sage fruit or flower       D: Yokuinin seed 50% 1,3-butylene glycol extract       * A decomposition liquid of any one of A to D 3.0     6.E: Soybean seed 50% 1,3-butylene glycol extract       F: 50% 1,3-butylene glycol extract of Rhododendron or rhizome       G: Tormentilla root or rhizome 50% 1,3-butylene glycol extract       H: Yukinoshita whole plant 50% 1,3-butylene glycol extract       * Any one of E to H decomposition solution 3.0     7. Lily bulb hot water extract 1.0     8. Spicy (Keirin Spicy) Rhizome Hot Water Extract 1.0     9. Rice bran hot water extract 1.0    10. Carpronium chloride 0.3    11. Hinokitiol 0.5    12. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    13. Perfume (Rosehip water) Suitable amount    14. Purified water 100 residue

[0188]  (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Trimethylene glycol 5.0     6.A: Sesame seed 50% ethanol extract       B: 50% ethanol extract of Sambucus nigra fruit or flower       C: Carrot rhizome or root bark 50% ethanol extract       D: Bakumondou rhizome or root bark 50% ethanol extract       * A decomposition liquid of any one of A to D 3.0     7. E: 50% ethanol extract of Rhizoma rhizome or root bark       F: Olive leaf or branch leaf 50% ethanol extract       G: Cuckon root or rhizome 50% ethanol extract       H: 50% ethanol extract of Prunus avium fruit or branches and leaves       * Any one of E to H decomposition solution 3.0     8. Lemon fruit 50% 1,3-butylene glycol extract 1.0     9. Apple fruit 30% ethanol extract 1.0    10. Wormwood 50% ethanol extract 1.0    11. Parsley whole plant 50% 1,3-butylene glycol extract 0.5    12. Azulene 0.3    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (Yuzu water) Suitable amount    15. Residue to make purified water 100

[0189] (Prescription example 23) Heartnic mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: 50% ethanol extract of Aloe vera leaves or stems       B: 50% ethanol extract of shiitake fruiting body or mycelium       C: Water-soluble β-1,3-glucan of Production Example 5       D: Yeast extract of Production Example 6       * A decomposition liquid of any one of A to D 3.0     5.E: 50% ethanol extract of rhizome or root bark       F: Clara root or rhizome 50% ethanol extract       G: Button root or rhizome 50% ethanol extract       H: Chlorella 50% ethanol extract       * Any one of E to H decomposition solution 3.0     6. Soybean seed fermented soybeans 1.0     7. Hamamelis leaf or bark hot water extract 1.0     8. Comfrey leaf or stem 50% ethanol extract 3.0     9. Loquat leaf 30% ethanol extract 1.0    10. Carpronium chloride 0.3    11. Pantethine solution 0.5    12. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (apple water)    15. Residue to make purified water 100

[0190] (Prescription example 24) Hair artic mass%     1.L-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: 50% ethanol extract of Aloe vera leaves or stems       B: Dokudami whole plant 50% ethanol extract       C: Water-soluble β-1,3-glucan of Production Example 5       D: Yeast extract of Production Example 6       * A decomposition liquid of any one of A to D 3.0     7.E: 50% ethanol extract of rhizome or root bark       F: Clara root or rhizome 50% ethanol extract       G: Aonori 50% ethanol extract       H: Kirinsai 50% ethanol extract       * Any one of E to H decomposition solution 3.0     8. Corn whole water hot water extract 1.0     9. Chicken wicker extraction solution 1.0    10. Carboxymethyl chitin solution 1.0    11. Vitamin E derivative 0.5    12. Pantethine solution 0.5    13. Preservative (phenoxyethanol) Appropriate amount    14. Perfume (sage water) appropriate amount    15. Residue to make purified water 100

[0191] (Prescription example 25) Hair growth and hair nourishing agent Mass%     1.Ethanol 60.0     2.A: Aloe vera leaf or stem 50% ethanol extract       B: 50% ethanol extract of Sambucus nigra fruit or flower       C: Carrot rhizome or root bark 50% ethanol extract       D: Bakumondou rhizome or root bark 50% ethanol extract       * A decomposition liquid of any one of A to D 3.0     3.E: 50% Ethanol Extract of Rhizome or Root Bark       F: Olive leaf or branch leaf 50% ethanol extract       G: Cuckon root or rhizome 50% ethanol extract       H: 50% ethanol extract of Prunus avium fruit or branches and leaves       * Any one of E to H decomposition solution 3.0     4. Collagen protein enzymatic degradation solution 2.0     5. Vitamin E derivative 0.5     6. Capsicum tincture 0.5     7. Resorcin 0.5     8. Dipotassium glycyrrhizinate 0.5     9. Carboxymethyl chitin solution 0.5    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0192] (Prescription example 26) Hair growth and hair nourishing agent mass%     1.Ethanol 60.0     2. Keratin protein enzymatic degradation solution 2.0     3.A-1: Aloe vera extract of Production Example 2       A-2: Almond extract of Production Example 2       A-3: Enokitake mushroom extract of Production Example 2       A-4: Eringii extract of Production Example 2       A-5: Sesame extract of Production Example 2       A-6: Sanyaku extract of Production Example 2       A-7: Shiitake extract of Production Example 2       A-8: Shimeji extract of Production Example 2       A-9: A dandelion extract of Production Example 2       A-10: Sambucus nigra extract of Production Example 2       A-11: Senkyu extract of Production Example 2       A-12: Assembly extract of Production Example 2       A-13: Sophoraceae extract of Production Example 2       A-14: Tsukuritake Extract of Production Example 2       A-15: Capsicum extract of Production Example 2       A-16: Touki extract of Production Example 2       A-17: Tonin extract of Production Example 2       A-18: Dokudami extract of Production Example 2       A-19: Nameko extract of Production Example 2       A-20: Carrot extract of Production Example 2       A-21: Bakumondou extract of Production Example 2       A-22: Agaricus extract of Production Example 2       A-23: Himematsutake Extract of Production Example 2       A-24: Maitake extract of Production Example 2       A-25: Mukge extract of Production Example 2       A-26: Yokuinin extract of Production Example 2       A-27: Chlorella extract of Production Example 4       A-28: Yeast extract of Production Example 6       A-29: Water-soluble β-1,3-glucan of Production Example 5       * Extract from one of A-1 to A-29 3.0     4. B-1: Peony extract of Production Example 2       B-2: Oolong tea extract of Production Example 2       B-3: Olive extract of Production Example 2       B-4: Cuckon extract of Production Example 2       B-5: Kawamura Artemisia extract of Production Example 2       B-6: Ginseng extract of Production Example 2       B-7: Clara extract of Production Example 2       B-8: Horse chestnut extract of Production Example 2       B-9: Rheum palmatum extract of Production Example 2       B-10: Soybean extract of Production Example 2       B-11: Clove extract of Production Example 2       B-12: Tsudukudami extract of Production Example 2       B-13: Tormentilla extract of Production Example 2       B-14: Grape extract of Production Example 2       B-15: Button extract of Production Example 2       B-16: Hop extract of Production Example 2       B-17: Michiyanagi extract of Production Example 2       B-18: Yasha extract of Production Example 2       B-19: Yukinoshita extract of Production Example 2       B-20: Whey of Production Example 7       B-21: Commercially available N-acetyltyrosine solution       B-22: Aonori Extract of Production Example 4       B-23: Ananaosa Extract of Production Example 4       B-24: Sea urchin extract of Production Example 4       B-25: Ginkgo biloba extract of Production Example 4       B-26: Kotoji Tsunomata extract of Production Example 4       B-27: Laminaria extract of Production Example 4       B-28: Sugi Nori extract of Production Example 4       B-29: Agar-agar extract of Production Example 4       B-30: Hijiki extract of Production Example 4       B-31: Hijirimen extract of Production Example 4       B-32: Hiba Mata Extract of Production Example 4       B-33: Seaweed extract of Production Example 4       * Any one of B-1 to B-33 extract 3.0     5. Cantharis tincture 0.5     6. Pantothenic acid derivative 0.2     7.β-glycyrrhetinic acid 0.2     8. Resorcin 0.2     9. Salicylic acid 0.2    10.Hydroxyethyl chitosan solution 0.2    11. Elastin hydrolyzate 0.2    12. Antibacterial and antiseptic (paraben) 0.1    13. Perfume (Lavender water) Suitable amount    14. Purified water 100 residue

[0193] (Prescription example 27) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 4.0     4.A: Aloe vera leaf or spore hot water extract dry powder       B: Dokudami whole grass hot water extract dry powder       C: dried elderberry fruit or flower hot water extract dried powder       D: Carrot rhizome or root bark hot water extract dry powder       * Any one of A to D dry powder 3.0     5.E: Dried powder of hot water extract of rhizome or root bark       F: Clara root or rhizome hot water extract dry powder       G: Aonori hot water extract dry powder       H: Kirinsai hot water extract dry powder       * Any one of E to H dry powder 3.0     6. Silk protein enzymatic decomposition solution dry powder 4.0     7. Jujuba whole plant hot water extract dry powder 1.0     8. Dye (Gunjo green)

[0194] (Prescription example 28) Granule bath agent mass%     1. Sodium hydrogen carbonate 38.0     2. Anhydrous sodium sulfate 30.0     3. Borax 2.0     4.A: Sesame seed 50% ethanol extract       B: Dry powder of agaric fruit body hot water extract       C: Dry powder of Maitake fruiting body hot water extract       D: Stark leaf or root hot water extract dry powder       * Any one of A to D dry powder 3.0     5.E: Dry powder of eucalyptus rhizome or root bark hot water extract       F: Tormentilla root or rhizome hot water extract dry powder       G: kelp hot water extract dry powder       H: Hiba mata hot water extract dry powder       * Any one of E to H dry powder 3.0     6. Collagen protein enzymatic decomposition solution dry powder 2.0     7. Peach leaf 70% ethanol extract dry powder 1.0     8. Dye (Gunjou, chromium hydroxide)

(Formulation Example 29) A coating solution containing a coating protectant gauze or liniment cloth impregnated with an appropriate amount such as a hot water extract of dandelion whole plant and a hot water extract of Dokudami whole plant, antibiotics, anti-inflammatory, etc. Attach to. Alternatively, the hot water extract of dandelion whole plant and the hot water extract of Dokudami whole plant may be directly sprayed locally and covered with gauze or the like.

[0196] (Prescription example 30) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6. Almond seed hot water extract dry powder 0.1     7. Grape fruit or leaf hot water extract dry powder 0.1     8. Dye (Gunjo green)     9. Residue to make purified water 100

[0197] (Prescription example 31) Detergent for tableware Mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Aloe vera leaf or stem hot water extract dry powder 3.0     6. Soybean seed hot water extract dry powder 3.0     7. Residue to make purified water 100

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test is for those who suffer from dry skin, lack of gloss and tension, and those who suffer from spots, freckles, and dark skin 3
Ten panelists, each aged 0 to 60 years old, were applied twice daily in the morning and at night, and after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, an emulsion prepared by blending only one kind of the essential component (A) or (B) of the present invention by the same method was used. or,
The evaluation method was performed based on the following criteria, and the results are shown in Tables 9 to 12, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of improving skin feel] Effective: Dry skin and gloss / tension of the skin were increased, and the skin was improved. Slightly effective: Dry skin and gloss / tension of the skin were slightly increased, and the skin was slightly improved. Ineffective: No change from before use.

[Blemish and freckles and skin color improving effect] Effectiveness: The freckles and freckles and the skin color were white and reduced. Slightly effective: The spots, freckles, and skin color were whitened and slightly reduced. Ineffective: No change from before use.

[0201]

[Table 9]

[0202]

[Table 10]

[0203]

[Table 11]

[0204]

[Table 12]

(Test Results) As shown in Tables 9 to 12, the components (A) of the present invention: aloe vera extract, chlorella extract, yeast extract, and (B) components: oyster, oolong tea, olive, cuckoo, wormwood, One or more kinds of plant extracts selected from linden, clara, horse chestnut, rhubarb, soybean, clove, ginkgo, tormentilla, grape, button, hop, willow, yasha, yukinoshita, or whey, N-acetyltyrosine or its derivative One or more selected from, or Aonori, Anaaosa,
An emulsion containing one or more seaweed extracts selected from sea urchin, giraffe, kotoji tsunomata, kelp, horse mackerel, agar, hijiki, hijirimen, hibamata, wakame, improves the dry skin significantly, and makes the skin shiny and firm. Also, the stains, freckles, and skin color were reduced to white.
A strong effect was recognized even when compared with the formulations of various single components of the present invention. Other (A) ingredients: almond,
Enokitake, eringii, sesame, sanyaku, shiitake,
Shimeji, dandelion, elderberry, senkyu, senburi, sokuhaku, Tsukutake mushrooms, capsicum, touki, tounin, dokudami, nameko, carrot,
One or more plant extracts selected from Bakumondou, Agaricus, Himematsutake, Maitake, Mukuge, Yokuinin,
Or 1 selected from water-soluble β-1,3-glucan derivatives
More than seeds (B) ingredient: oyster, oolong tea, olive,
Cuckoo, Japanese mugwort, Japanese linden, Clara, Violets, Rhubarb, Soybean, Clove, Tsurudami,
Tormentilla, grapes, buttons, hops, willow,
One or more plant extracts selected from Yasha and Yukinoshita, or one or more selected from whey, N-acetyltyrosine or a derivative thereof, or Aonori, Anahusa, Umiuchiwa, Kirinsai, Kotojitsunomata, Kombu, Astragalus, Amanita, Hijiki. Also, with regard to an emulsion containing a combination of one or more seaweed extracts selected from Hijirimen, Hibamata and Wakame, it improves dry skin and gives it gloss and tension.
In addition, stains, freckles, and skin color were also reduced to white, and even when compared with the formulations of various single components of the present invention, the same strong effects as above were recognized.

[0206]

INDUSTRIAL APPLICABILITY The present invention includes (A) aloe vera, almond, enokitake, eringi, sesame, as essential ingredients,
Sanyaku, shiitake, shimeji mushroom, dandelion, elderberry, senkyu, senburi, sokuhaku, Tsukutake mushroom, capsicum, touki, tounin, dokudami,
Nameko, carrot, Bakumondou, agaricus, Himematsutake, Maitake, Mukuge, Yokuinin one or more kinds of plant extract, or chlorella extract, yeast extract,
Any one or more selected from water-soluble β-1,3-glucan derivatives, and further (B) oyster, oolong tea, olive, cuckoo, wormwood, linden, clara, hollyhock, rhubarb, soybean, clove, woodcutter, Tormentilla, grape, button, hops, willow, yasha, one or more plant extracts selected from Yukinoshita, or one or more selected from whey, N-acetyltyrosine or a derivative thereof, or Aonori, Anaaosa, Sea Urchin, Kirinsai. , A melanin production inhibitor or a fibroblast proliferation promoter to which one or more seaweed extracts selected from the group consisting of seaweed extract, kombu, kelp, horse mackerel, proboscis, hijiki, hijirimen, hibamata and wakame are added together, and a cosmetic composition containing the same Has an excellent inhibitory effect on melanin production. It can also reduce the whiteness of dregs or skin (whitening effect), and also has a fibroblast proliferation promoting action, which can improve dry skin and give the skin gloss and tension. still,
It is safe for humans and animals, and can also be used for general food and drink.

─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. ⁷ Identification Code FI Theme Coat (Reference) A61K 7/26 A61K 7/26 7/48 7/48 7/50 7/50 35/78 35/78 W A61P 17/16 A61P 17/16 F-term (reference) 4C083 AA031 AA032 AA071 AA072 AA082 AA111 AA112 AA122 AB032 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC022 AC072 AC102 AC112 AC122 AC132 AC182 AC242 AC342 AC422 AC432 AC442 AC472 AC482 AC542 AC552 AC582 AC642 AC692 AC782 AC852 AC862 AC902 AD042 AD092 AD112 AD272 AD312 AD322 AD392 AD432 AD442 AD452 AD512 AD532 AD552 AD642 AD662 4C088 AA02 AA04 AA07 AA08 AA13 AA14 AA15 AA16 AB12 AB13 AB14 AB16 AB26 AB56 AB56 AB56 AB56 AB56 AB56 AB56 AB56 AB52 AB59 AB56 AB56 AB52 AB52 AB47 AB56 AB48 AB67 AB73 AB86 AC01 AC04 AC05 AC11 BA07 BA08 MA07 MA08 MA16 MA28 MA63 NA05 NA14 ZA89 ZA92 ZB21

Claims (3)

[Claims] 1. A melanin production inhibitor characterized by containing the following (A) and (B) as essential components. (A) Aloe vera, almond, enoki mushroom, eringi, sesame, sanyaku, shiitake mushroom, shimeji mushroom, dandelion, elderberry, senkyu, senburi, sohakuhi, tsukuritake mushroom, capsicum, touki, tonin,
One or more kinds of plant extract or chlorella extract selected from Dokudami, Nameko, Carrot, Bakumondo, Agaricus, Himematsutake, Maitake, Mukuge, Yokuinin,
One or more selected from yeast extract and water-soluble β-1,3-glucan derivative. (B) oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, holly cypress, rhubarb, soybean, clove, clover, tormentilla,
One or more plant extracts selected from grapes, buttons, hops, willow trees, yashas, and Yukinoshita, or whey, N
-One or more kinds selected from acetyltyrosine or a derivative thereof, or one or more kinds of seaweed extracts selected from Aono-ori, Anahusa, Sea Urchin, Kirinsai, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hibamata and Wakame. 2. A fibroblast proliferation promoter, which comprises the following (A) and (B) as essential components. (A) Aloe vera, almond, enoki mushroom, eringi, sesame, sanyaku, shiitake mushroom, shimeji mushroom, dandelion, elderberry, senkyu, senburi, sohakuhi, tsukuritake mushroom, capsicum, touki, tonin,
One or more kinds of plant extract or chlorella extract selected from Dokudami, Nameko, Carrot, Bakumondo, Agaricus, Himematsutake, Maitake, Mukuge, Yokuinin,
One or more selected from yeast extract and water-soluble β-1,3-glucan derivative. (B) oyster, oolong tea, olive, cuckoo, sagebrush, linden, clara, holly cypress, rhubarb, soybean, clove, clover, tormentilla,
One or more plant extracts selected from grapes, buttons, hops, willow trees, yashas, and Yukinoshita, or whey, N
-One or more kinds selected from acetyltyrosine or a derivative thereof, or one or more kinds of seaweed extracts selected from Aono-ori, Anahusa, Sea Urchin, Kirinsai, Kotoji Tsunomata, Kombu, Scutellaria, Astragalus, Hijiki, Hijirimen, Hibamata and Wakame. 3. A cosmetic composition comprising any one or more of the melanin production inhibitor and the fibroblast proliferation promoter according to any one of claims 1 to 2.