CN105078802A - Acidic polypeptide transdermal caring agent and method for preparing same - Google Patents
Acidic polypeptide transdermal caring agent and method for preparing same Download PDFInfo
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- CN105078802A CN105078802A CN201410203511.3A CN201410203511A CN105078802A CN 105078802 A CN105078802 A CN 105078802A CN 201410203511 A CN201410203511 A CN 201410203511A CN 105078802 A CN105078802 A CN 105078802A
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- acid polypeptide
- transdermal
- hirudin
- hirudo
- olibanum
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Abstract
The invention discloses an acidic polypeptide transdermal caring agent and a method for preparing the same. The acidic polypeptide transdermal caring agent and the method have the advantages that pharmacological characteristics of extracting liquid of acidic polypeptides of hirudin, frankincense and the like are sufficiently utilized to prepare the skin caring agent, antibacterial, anti-inflammation, dead epidermis removing, skin nourishing, freckle removing and cell self-repairing ability improving effects can be realized for the skins of human bodies, growth of melanocytes can be inhibited, effects of eliminating sunburn and hyperpigmentation on the faces of the human bodies and the like can be realized, and the acidic polypeptide transdermal caring agent is suitable for people suffering from various epidermis color spots and roughness, alopecia, dermatitis, local soft tissue pain and injuries from falls.
Description
Technical field
The invention belongs to article of everyday use, a kind of pure natural hirudin extracts people's external use Acid polypeptide transdermal sealing compound and preparation method thereof specifically.
Background technology
Hirudo is the medical material kind that Chinese Pharmacopoeia records, and function removing blood stasis, removing blood stasis, stimulates the menstrual flow, for note of the ancient Chinese abdominal mass mass in the abdomen, blood stasis amenorrhea, traumatic injury.Hirudo begins to be loaded in Shennong's Herbal: " master closed by stagnant blood, congestion, the moon, and removing blood stasis abdominal mass is gathered, loss of fecundity, dredging water passages ".The hirudin Acid polypeptide that Hirudo is extracted is the natural thrombin inhibitor comparatively commonly used, and it contains 65-66 aminoacid, has the features such as good anticoagulant, the effect of anti-arteriovenous thrombosis and toxic and side effects are low.
At present, extract or its main component hirudin of Hirudo is used in existing more daily use chemicals product, for speckle dispelling, prevention skin aging, but there is not yet hirudin to be combined with other Chinese medicine ingredients and there is inhibiting bacteria and diminishing inflammation simultaneously, to go to epidermis dead angle, local soft tissue of releiving pain, bone joint pain, dermatitis, effect of speckle dispelling, prevention skin aging.Inventor expects to utilize the combination of Hirudo and each Chinese herbal medicine for maintenance that is facial and whole skin.
Summary of the invention
A kind of hirudin that is to provide of mother of the present invention extracts people's external use Acid polypeptide transdermal sealing compound, make full use of the pharmacological property of the extracting solution of hirudin Acid polypeptide and Olibanum etc., be mixed with skin nutritious agent, inhibiting bacteria and diminishing inflammation can be had to human skin, go to epidermis dead angle, nutrition skin, speckle dispelling, improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation, by the liquid preparation of ultrasonic extraction technique gained, independently directly can be penetrated to the skin skin corium, be easy to be absorbed by the skin, outstanding skin penetration has blood circulation promoting and blood stasis dispelling to body local soft tissue, warm cold expelling, effect of reducing swelling and alleviating pain, the present invention also provides production technology, simple to operation.
A kind of Acid polypeptide transdermal sealing compound, comprises the extracting solution composition of hirudin Acid polypeptide and Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the extraction of sachet grass equal portions.
Wherein the effect of each raw material is as follows:
Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha: cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection swell and ache curative effect, have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen.
Semen Persicae: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Rhizoma Zingiberis: warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation.Control trusted subordinate's cold type of pain, vomit and diarrhoea, cold extremities faint pulse, breath with cough for cold time, anemofrigid-damp arthralgia, yang deficiency is told, be defeated in battle, hematochezia.
Sachet grass: formal name used at school is Herba Capsellae, has the effects such as clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, suppressing the hyperactive liver improving eyesight, to dysentery, edema, spit blood, the disease such as to have blood in stool has remarkable effect.
Hirudin: hirudin can directly penetrate to the skin deep layer, is easily absorbed by Skin Cell.Hirudin independently penetrates into facial blood capillary: the blood viscosity reducing facial vessels, accelerate facial blood flow speed, dredge facial blood capillary, improve facial microcirculation, reduce cuticle thickness after facilitating skin of face metabolism, make cell obtain sufficient nutrient, improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation; Improve flap venous congestion, be suppressed to fibrocyte and grow up and development, suppress and eliminate hypertrophic cicatrix and epidermis fat to silt up.
The object of the invention is to be achieved through the following technical solutions:
A kind of Acid polypeptide transdermal sealing compound, comprise extracting solution two kinds of components of the Olibanum of hirudin Acid polypeptide, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the extraction of sachet grass equal portions, the proportioning of the extracting solution of hirudin Acid polypeptide and Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, sachet grass is 5: 100.When making Acid polypeptide transdermal sealing compound of the present invention, Hirudo entirety can be immersed in 0.9% normal saline 4 hours, clean worry solid carbon dioxide point entirety and break into paste-like, Hirudo slurry is placed the steaming of wetting of wet steaming machine and is carried out sterilizing, temperature regulates at 60-80 degree Celsius, 30 minutes time, by Hirudo slurry more than 95% alcohol settling after sterilizing, first adding 95% ethanol makes Hirudo slurry content be 50%, place after 24 hours, the ethanol adding same concentration again makes Hirudo slurry content be 75%, place 24 hours, obtain hirudin Acid polypeptide precipitation, Acid polypeptide is precipitated cold drying and obtains semifinished product, for subsequent use, by Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the equal equal portions of sachet grass component, with distilled water, proportioning is 50: 100, soak after 24-48 hour, heat to 50-60 degree Celsius, the time is 30 minutes, after extracting 8 times with micromolecule ultrasonic extracting machine again after cooling, extracting solution is obtained with 1000 object strainer filterings, for subsequent use, by the extracting solution device of above-mentioned Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, sachet grass at the required container blent, then add hirudin Acid polypeptide semifinished product in the ratio of 100: 5, stir gently with sterile chamber glue rod, slightly seeing has foam.
The invention has the beneficial effects as follows: there is various osteoarthritis of releiving, local soft tissue pain, traumatic injury, eliminate chronic and refractory pain disease, blood circulation promoting and blood stasis dispelling is had to body local soft tissue, warm cold expelling, the effect of reducing swelling and alleviating pain, inhibiting bacteria and diminishing inflammation can be had to human skin, go to epidermis dead angle, control alopecia, nutrition skin, speckle dispelling, improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation, sealing compound abnormal smells from the patient fragrant is natural, the micro-Huang of color and luster is bright, visible foam when understanding liquid, be applicable to various epidermis mottle, coarse, alopecia, dermatitis, local soft tissue pain, the crowd of traumatic injury.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Transdermal sealing compound of the present invention has various osteoarthritis of releiving, local soft tissue pain, traumatic injury, eliminate chronic and refractory pain disease, body local soft tissue is had to the effect of blood circulation promoting and blood stasis dispelling, warm cold expelling, reducing swelling and alleviating pain, inhibiting bacteria and diminishing inflammation can be had to human skin, go to epidermis dead angle, control alopecia, nutrition skin, speckle dispelling, raising cell self-repairing capability, the growth of check melanin cell, the facial sunburn that disappears and Pigmented effect.
Using method: instill appropriate Acid polypeptide transdermal sealing compound at bone joint pain position or skin care position, then with Cornu Bovis seu Bubali scraper plate gently repeatedly scraping infiltrate completely in skin to sealing compound liquid, so 2-5 time repeatedly, painful area is shown in has petechia to discharge.
Effect shows: for various osteoarthritis, local soft tissue pain, beat and damage the wounded, use and once can obviously releive about over the course of 15 mins, the use of chronic and refractory pain disease 7-30 time can eliminate pain symptom completely.
For various epidermis mottle, coarse, alopecia, dermatitis symptom person, general use is for 7-15 time a cycle, and slight person is a cycle, and serious symptom person can reach desirable recovery effects at 2-3 cycle, and does not generally rebound.
Hirudo entirety to be immersed in 0.9% normal saline 4 hours, clean worry solid carbon dioxide point entirety and break into paste-like, Hirudo slurry is placed the steaming of wetting of wet steaming machine and is carried out sterilizing, temperature regulates at 60-80 degree Celsius, 30 minutes time, by Hirudo slurry more than 95% alcohol settling after sterilizing, first adding 95% ethanol makes Hirudo slurry content be 50%, place after 24 hours, the ethanol adding same concentration again makes Hirudo slurry content be 75%, places 24 hours, obtains hirudin Acid polypeptide precipitation, Acid polypeptide is precipitated cold drying and obtains semifinished product, for subsequent use; By Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the equal equal portions of sachet grass component, with distilled water, proportioning is 50: 100, soak after 24-48 hour, heat to 50-60 degree Celsius, the time is 30 minutes, after extracting 8 times with micromolecule ultrasonic extracting machine again after cooling, extracting solution is obtained with 1000 object strainer filterings, for subsequent use; By the extracting solution device of above-mentioned Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, sachet grass at the required container blent, then add hirudin Acid polypeptide semifinished product in the ratio of 100: 5, stir gently with sterile chamber glue rod, slightly seeing has foam.
Should be understood that, application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (2)
1. an Acid polypeptide transdermal sealing compound, comprise extracting solution two kinds of components of the Olibanum of hirudin Acid polypeptide, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the extraction of sachet grass equal portions, the proportioning of the extracting solution of hirudin Acid polypeptide and Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, sachet grass is 5: 100.
2. Acid polypeptide transdermal sealing compound according to claim 1, when it is characterized in that making Acid polypeptide transdermal sealing compound of the present invention, Hirudo entirety can be immersed in 0.9% normal saline 4 hours, clean worry solid carbon dioxide point entirety and break into paste-like, Hirudo slurry is placed the steaming of wetting of wet steaming machine and is carried out sterilizing, temperature regulates at 60-80 degree Celsius, 30 minutes time, by Hirudo slurry more than 95% alcohol settling after sterilizing, first adding 95% ethanol makes Hirudo slurry content be 50%, place after 24 hours, the ethanol adding same concentration again makes Hirudo slurry content be 75%, place 24 hours, obtain hirudin Acid polypeptide precipitation, Acid polypeptide is precipitated cold drying and obtains semifinished product, for subsequent use, by Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, the equal equal portions of sachet grass component, with distilled water, proportioning is 50: 100, soak after 24-48 hour, heat to 50-60 degree Celsius, the time is 30 minutes, after extracting 8 times with micromolecule ultrasonic extracting machine again after cooling, extracting solution is obtained with 1000 object strainer filterings, for subsequent use, by the extracting solution device of above-mentioned Olibanum, Myrrha, Flos Carthami, Semen Persicae, Rhizoma Zingiberis, sachet grass at the required container blent, then add hirudin Acid polypeptide semifinished product in the ratio of 100: 5, stir gently with sterile chamber glue rod, slightly seeing has foam.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410203511.3A CN105078802A (en) | 2014-05-15 | 2014-05-15 | Acidic polypeptide transdermal caring agent and method for preparing same |
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| CN201410203511.3A CN105078802A (en) | 2014-05-15 | 2014-05-15 | Acidic polypeptide transdermal caring agent and method for preparing same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412414A (en) * | 2015-12-05 | 2016-03-23 | 重庆市中药研究院 | Skin care hirudo nipponica composition and preparation method thereof |
| CN105617370A (en) * | 2016-01-28 | 2016-06-01 | 广州市当志强医药科技有限公司 | Hirudin blood stasis-removing paste and preparation method thereof |
| CN107519036A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of striae of pregnancy spray containing polypeptide and preparation method thereof |
| CN108939058A (en) * | 2018-09-12 | 2018-12-07 | 荆州市致强生物科技有限公司 | A kind of Chinese materia medica preparation and preparation method of promoting blood circulation and stopping pain |
| CN109395053A (en) * | 2018-12-25 | 2019-03-01 | 本草方剂(珠海)医药有限公司 | A kind of rubber ointment for treating thrombotic Superficial veins inflammation |
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| CN1732897A (en) * | 2005-08-16 | 2006-02-15 | 周维海 | Face-beautifying skin-caring lotion with leech extract and its preparation process |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
| CN103784541A (en) * | 2014-02-11 | 2014-05-14 | 车金徽 | Traditional Chinese medicine for treating pains on neck, shoulders, waist and legs |
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2014
- 2014-05-15 CN CN201410203511.3A patent/CN105078802A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1732897A (en) * | 2005-08-16 | 2006-02-15 | 周维海 | Face-beautifying skin-caring lotion with leech extract and its preparation process |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412414A (en) * | 2015-12-05 | 2016-03-23 | 重庆市中药研究院 | Skin care hirudo nipponica composition and preparation method thereof |
| CN105617370A (en) * | 2016-01-28 | 2016-06-01 | 广州市当志强医药科技有限公司 | Hirudin blood stasis-removing paste and preparation method thereof |
| CN107519036A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of striae of pregnancy spray containing polypeptide and preparation method thereof |
| CN108939058A (en) * | 2018-09-12 | 2018-12-07 | 荆州市致强生物科技有限公司 | A kind of Chinese materia medica preparation and preparation method of promoting blood circulation and stopping pain |
| CN109395053A (en) * | 2018-12-25 | 2019-03-01 | 本草方剂(珠海)医药有限公司 | A kind of rubber ointment for treating thrombotic Superficial veins inflammation |
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Application publication date: 20151125 |
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