CN104288055A - Chinese herbal medicine composition containing saussurea medusa as well as preparation method and application of Chinese herbal medicine composition - Google Patents
Chinese herbal medicine composition containing saussurea medusa as well as preparation method and application of Chinese herbal medicine composition Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine composition containing saussurea medusa. The Chinese herbal medicine composition is prepared from the following raw material components in parts by weight: 10-50 parts of saussurea medusa, 10-40 parts of rhizoma drynariae, 10-40 parts of myricaria laxiflora and 8-35 parts of conic gymnadenia tuber. The invention also discloses a preparation method and application of the Chinese herbal medicine composition. The Chinese herbal medicine composition disclosed by the invention is prepared by matching and extracting various Chinese herbal medicines through applying monarch and minister as well as assistant and guide theoretical guidance of the traditional Chinese medicine and combining the modern research; when being used as a functional additive to be added into a cosmetic system, the Chinese herbal medicine composition not only can play roles in tendering the skin and preventing the skin from excessively fast aging, but also has the health effects of dispelling rheumatic arthritis as well as preventing and relieving pain caused by arthritis, internal lesion caused by overexertion and dysmenorrheal caused by female uterine cold, and the skin irritation caused by independently applying a saussurea medusa extracting solution serving as a monarch drug to cosmetics is also greatly relieved.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of herbal composite containing Saussurea medusa Maxim. and its preparation method and application.
Background technology
Along with the change that human aesthetic sees, the pattern of dress ornament trend " short ", " dew ", " thoroughly ", so single product such as various camisole, mini-skirt, high-heel shoes start one popular upsurge, and prolongedly not to take off.Women exposes charming long leg and sexy umbilicus, costs the high-heel shoes of fashion; Man exposes a line of scenery that solid arm flesh and chest muscle become street corner.But the disease risk that the long-term exposure in various body joints position brings can't neglect.Show according to investigations, the sickness rate of rheumatoid arthritis rises year by year, and the trend of rejuvenation appears in morbidity crowd; And according to another investigation display, the women's quantity suffering from cold womb is quite huge, can say, just has six cold womb in ten women.And one that causes these diseases to popularize important reason is exactly cold invasion.Navel, the shoulder back of the body, these positions of knee are all the links of health weakness, be chronically exposed in external environment or air conditioner surroundings and the skin around these positions not only can be made because of hydropenia or damage to become coarse, dim, accelerate the ager process of skin, also easily cause the disease such as similar rheumatic arthritis, cold womb dysmenorrhea.
Popular along with plant skin protection theory, the cosmetics adding natural plant composition enjoy the favor of consumer.Declare that there is skin care in the market, aging-resistant cosmetics are countless, but even the cosmetic applications having other health-care effecies concurrently is wideless, and on market existing by natural product or plant extract for the cosmetics added are mainly with based on the pharmacological research of single medicinal material, effect is single; Or be the simple combination of single vegetable Chinese herbal medicine extract, lack the guidance of Chinese medical theory and the research of compound recipe, complementary effect can not be played.
Summary of the invention
In order to overcome above-mentioned the deficiencies in the prior art, the present invention instructs, adopt modern study means, provide a kind of and there is skin-care effect have the natural safety of health-care effect, the herbal composite of Synergistic and the preparation method of this herbal composite and the application in cosmetics thereof simultaneously concurrently.
The present invention's technical scheme adopted that will solve the problem is a kind of herbal composite containing Saussurea medusa Maxim., and the raw material composition of said composition and parts by weight proportioning are: Saussurea medusa Maxim. 10-50 part; Rhizoma Drynariae 10-40 part; Cacumen Myricariae Germanicae 10-40 part; Rhizoma Gymnadeniae 8-35 part.
Preferably, herbal composite raw material composition of the present invention and weight proportion are: Saussurea medusa Maxim. 15-45 part; Rhizoma Drynariae 15-35 part; Cacumen Myricariae Germanicae 15-35 part; Rhizoma Gymnadeniae 13-30 part.
Preferred raw material composition and weight proportion are: Saussurea medusa Maxim. 40 parts; Rhizoma Drynariae 30 parts; Cacumen Myricariae Germanicae 30 parts; Rhizoma Gymnadeniae 20 parts.
The present invention also provides this herbal composite preparation method, comprises the following steps:
(1) get and cleaned up and removed deimpurity Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae, the rear mixing of dry, pulverizing respectively, put into ultrosonic extractor, 10-30 distilled water is doubly added according to the gross weight of Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae melange, dipping half an hour after in 40-80 DEG C of ultrasonic extraction method 20-40 minute, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) the hydrophilic Extraction solvent that solid-liquid ratio is 1:10-50 is added in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor in 50-80 DEG C of ultrasonic extraction method 20-40 minute, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained herbal composite.
Above preparation method, the hydrophilic Extraction solvent described in step (2) is ethanol, methanol, butanediol, propylene glycol or ethyl acetate, and the volume fraction of solvent is 70-90%.
Described hyperacoustic power is 100-300W.
The present invention also provide this herbal composite preparation there is skin care, the application prevented in the cosmetics of the too fast aging effect of skin.
The present invention provides this herbal composite to have the application in the cosmetics of dysmenorrhea effect that pain, impairment caused by overstrain and women's cold womb of dispelling articular rheumatic, prevention and releasing arthritis and causing cause in preparation simultaneously.
Cosmetics described are in certain embodiments emollient cream.
The invention provides a kind of emollient cream, described emollient cream, comprise each component of following percentage by weight:
Herbal composite: 2-15wt%,
Emulsifying agent: 3-5wt%,
Thickening agent: 0.1-1wt%,
Emollient: 8-20wt%,
Wetting agent: 5-15wt%,
Antiinflammatory: 0.1-0.6wt%,
PH conditioner: 0.1-0.5wt%,
Transdermal enhancer: 0.5-2wt%,
Antiseptic: 0.2-1wt%,
Deionized water: surplus;
Described herbal composite is the mixed extract according to the Saussurea medusa Maxim. obtained by herbal composite preparation method of the present invention, Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae;
Described emulsifying agent is at least one in sorbitan stearate, cetearyl alcohol or PEG-60 Span60;
Described thickening agent is at least one in carbomer, xanthan gum or hydroxyethyl-cellulose;
Described emollient is at least one in polydimethylsiloxane, hydrogenated olive oil, ring five polydimethylsiloxane/cyclohexasiloxane, hydrogenated jojoba oil, caprylic/capric triglyceride or squalane;
Described wetting agent is at least one in glycerol, propylene glycol, hyaluronate sodium, oligofructose;
Described antiinflammatory is at least one in allantoin, glycyrrhizic acid dipotassium;
Described PH conditioner is at least one in potassium hydroxide, triethanolamine;
Described transdermal enhancer is at least one in tetrahydrochysene piperine, azone;
Described antiseptic is at least one in phenoxyethanol, sodium benzoate or 1,2-hexanediol/caprylyl glycol.
Emollient cream described in certain embodiments, comprises each component of following percentage by weight:
Herbal composite: 2-10wt%,
Emulsifying agent: 3-5wt%,
Thickening agent: 0.1-0.5wt%,
Emollient: 8-20wt%,
Wetting agent: 5-13wt%,
Antiinflammatory: 0.1-0.4wt%,
PH conditioner: 0.1-0.5wt%,
Transdermal enhancer: 0.5-1.5wt%,
Antiseptic: 0.2-0.7wt%,
Deionized water: surplus;
Described herbal composite is the mixed extract according to the Saussurea medusa Maxim. obtained by herbal composite preparation method of the present invention, Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae;
Described emulsifying agent is at least one in sorbitan stearate, cetearyl alcohol or PEG-60 Span60;
Described thickening agent is at least one in carbomer, xanthan gum;
Described emollient is at least one in polydimethylsiloxane, hydrogenated olive oil, ring five polydimethylsiloxane/cyclohexasiloxane, caprylic/capric triglyceride or squalane;
Described wetting agent is at least one in glycerol, propylene glycol, hyaluronate sodium, oligofructose;
Described antiinflammatory is allantoin;
Described PH conditioner is triethanolamine;
Described transdermal enhancer is azone;
Described antiseptic is phenoxyethanol.
In above-mentioned formula, Saussurea medusa Maxim. is born on the Alpine screes of more than height above sea level 4000m, is distributed in the ground such as Gansu, Qinghai, Sichuan, Yunnan, Tibet." the little knowledge in Citrus chachiensis Hort. garden ": the raw Tibet of Herba Saussureae Involueratae, in Tibetan, accumulated snow does not disappear, early summer in late spring, is born in snow, and shape is as cockscomb, and floral leaf is born a close resemblance to, and spend high chi to be permitted, female male phase is also given birth to, and female person spends circle, and male person spends point, and color depth is red.Saussurea medusa Maxim. herb sweet-bitter flavor, warm in nature, enter liver,spleen,kidney three warp, function cures mainly: except cold, strong muscle is active, kidney invigorating and YANG supporting, and regulating menstruation, invigorates blood circulation.Control sexual impotence, waist knee joint is weak, women's metrorrhagia and leukorrhagia, menoxenia, rheumatic arthritis, traumatic hemorrhage, and external application is subsided a swelling." the little knowledge in Citrus chachiensis Hort. garden ": " except cold phlegm, supporing yang road." " detailed outline is picked up any lost article from the road ": " control all sympotoms caused by cold factors." " Traditional Chinese Medicine in Sichuan will ": " except cold-phlegm diseases caused by retention of fluid, tonifying YANG, enriches blood, warm uterus.Control impotence in male, woman's menoxenia and metrorrhagia and leukorrhagia." " Chinese Herbal Medicine in Xinjiang handbook ": " restore menstrual flow and invigorate blood circulation, bone and muscle strengthening, promotes uterine contraction.Treating rheumatic arthritis, women's cold and pain in the lower abdomen, amenorrhea, placenta retention, measles without adequate eruption, lung cold cough, sexual impotence." " Yunnan Chinese herbal medicine " " regulating menstruation, hemostasis, controls menoxenia, snow blindness, toothache, traumatic hemorrhage." " Tibetan medicine " proper bar of really reviving: herb is used for head trauma, anthrax, hot twinge, gynaecopathia, rheumatoid arthritis, apoplexy.
Rhizoma Drynariae is the dry rhizome of Mongolian oak Herba pteridii latiusculi, and bitter in the mouth is warm in nature, returns kidney, Liver Channel.Function cures mainly: the kidney invigorating bone strengthening, continues and hinders pain relieving, invigorate blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " five kinds of over strain six types of severe debility disease, mouth (one makes ' foot ') hands is not received, upper heat and lower cold for poison in main bone, wind blood pain." " book on Chinese herbal medicine is just ": " treat bone to be possessed poison, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs.”
Cacumen Myricariae Germanicae is Cacumen Tamaricis section Myricaria plant Cacumen Myricariae Germanicae, is used as medicine, is born in waterside, river shoal with sprout, the ground such as distribution Qinghai, Gansu, Shaanxi, Sichuan, Tibet, Shanxi, Yunnan." Chinese herbal medicine is commonly used in Tibet ": " property is put down, sweet-salty." " Chinese herbal medicine handbook is commonly used in Qinghai ": " Xin Gan, temperature." be included into lung, stomach, kidney three warp." Chinese herbal medicine is commonly used in Tibet ": " dispelling wind, induces sweat, rash, cough-relieving, heat-clearing and toxic substances removing.Cure mainly measles early stage, fever and cough, acute and chronic rheumatic arthritis.”
Rhizoma Gymnadeniae the orchid family herbaceos perennial, has another name called: " Rhizoma Gymnadeniae ".Originate in Eastern Tibet, East of Qinghai Province, western Sichuan, northwestern Yunnan Province, Gansu, Shaanxi and the district such as North China, northeast, grow at height above sea level 1,300-3, on the hillside sylvan life of 600 meters or meadow.Its tuber Tibetan medicine, the traditional Chinese medical science are all medicinal.Its sweet in the mouth is put down, and enters lung, spleen, stomach warp.Function cures mainly: benefiting vital QI and blood, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, asthenia is become thin, neurasthenia, and chronic diarrhea is lost blood, leukorrhagia, and breast is few, chronic hepatitis, rheumatism." Chinese Tibetan medicine " carries: " tonify Qi of the kidney, spermatogenesis, lung moistening.Cure mainly pneumonopathy, cough and asthma due to lung deficiency, meat poison, seminal emission sexual impotence." " will planted by northeast medicine ": " make mucus, for poisoning and under rushing down; Steep in wine as strong, essence-replenishing preparation." " Shanxi Chinese medicinal herbal ": " astringing to arrest bleeding, removing toxic substances.Control chronic diarrhea to lose blood, gonorrhea, leukorrhagia." " illustrated handbook planted by middle traditional Chinese medicines ": " repercussive.Control traumatic injury, hematocele is not all right." " Chinese herbal medicine is commonly used in Sichuan ": " blood yiqi, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, chronic consumptive disease weakness and emaciation, hypogalactia juice." " Shaanxi Chinese herbal medicine ": " strengthening by means of tonics, spleen reinforcing lung moistening are calmed the nerves relieving convulsion, QI invigorating pain relieving.Control physical weakness, neurasthenia, impairment caused by overstrain, cough, asthma." " the sweet peaceful blue or green Chinese herbal medicine in Shan ": " the kidney invigorating benefit is empty, promoting the circulation of blood of regulating the flow of vital energy.”
According to Chinese medical theory and Constitution Theory in TCM, skin is a part for human body, and embodies human body constitution state, and the traditional Chinese medical science thinks that the aging of skin and lung, spleen, the dirty function of kidney three are unbalance in close relations, is the external embodiment of internal organs negative and positive of qi and blood change in body." deficiency of the lung, withered skin and hair is withered; Insufficiency of the spleen, shallow complexion; Deficiency of kidney-essence, complexion is black dull, geromorphism; Stagnation of QI blood is tired, squamous and dry skin, skin aging.The full then whole body skin of QI and blood, the sliding tender gloss of face are flexible." Chinese medicine thinks, rheumatic arthritis is because the evil heterozygosis of wind, cold, wet forms disease, stagnates in joint, muscle, and hinder mechanism of qi to run, general rule does not have pain.Theory of Chinese medical science is thought: the reason causing dysmenorrhea, mainly contains two kinds: one is " stagnation of QI and blood may bring about pain ", and one is " not Rong Ze pain ".The former causes because of blood stasis, cold coagulation, and namely dysmenorrhea has cold syndrome to show simultaneously, treats logical based on temperature, warm palace; The latter loses cause in moistening to support because of deficient qi and blood, passages through which vital energy circulates, and treatment should based on benefiting qi and nourishing blood.
In the present invention, take Saussurea medusa Maxim. as monarch, get it except cold, strong muscle is active, kidney invigorating and YANG supporting, regulating menstruation, and effect of invigorating blood circulation plays and dispels basic effect, consolidates the effect on basis.Rhizoma Drynariae the kidney invigorating bone strengthening, continuous hinders pain relieving, invigorates blood circulation, and treats bone and to be possessed poison, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism; Cacumen Myricariae Germanicae dispelling wind, induces sweat, rash, cough-relieving, heat-clearing and toxic substances removing.Cure mainly measles early stage, fever and cough, acute and chronic rheumatic arthritis, both can assist monarch drug to play effect, strengthen the effectiveness of monarch drug.Rhizoma Gymnadeniae benefiting vital QI and blood, promoting the production of body fluid to quench thirst, removing toxic substances, exercises QI and blood, not only reaches to moisten to support moist object, can also in and in formula principal agent side effect thus be adjuvant drug.All medicines share above, and play altogether except cold, strong muscle is active, kidney invigorating and YANG supporting, benefiting vital QI and blood, effect of blood-activating and qi-promoting, the function between each internal organs such as balance lung, spleen, kidney.
Modern study also proves the decoct of Saussurea medusa Maxim., ethanol extraction have significantly anti-inflammatory and antalgic, antibody Monoclonal, scavenging free radicals, improve vascular permeability effects.It all has significant antagonism to the joint acute inflammation that rat is caused by formaldehyde or egg white solution, and hot plate method in mice is tested, and Saussurea involucrate general flavone and Herba Saussureae Involueratae injection all have stronger analgesic activity; Rhizoma Drynariae extract has significantly activation and proliferation function to fibroblast, can promote that fibrous cartilage heals, osteoporosis, has antiinflammatory, antioxidation in addition concurrently, improves effect of vascular permeability and blood circulation promoting and blood stasis dispelling, anti-poisoning, check melanin cytoactive.Rhizoma Drynariae water decoction 7.5-50g/kg gavage, has Rat Experimental arthritis and stimulates bone articular cartilage compensatory cellular proliferative effect, and can partly improve because mechanical stress line changes the degeneration causing articular cartilage, thus reduce osteoarthritis variability; Cacumen Myricariae Germanicae extract has the effect of antiinflammatory, resisting fatigue, raising immunity; The herb of Rhizoma Gymnadeniae is containing volatile oil 6%, and mucous matter 50% in tuber, starch 27%, protein 3%, sugar 5%, other are still containing calcium oxalate, inorganic salt.The method extracting Rhizoma Bletillae gel by Pseudobulbus Bletillae (Rhizoma Bletillae) measures, containing colloid 62.9% in Rhizoma Gymnadeniae tuber.It has effects such as improving immunity, resisting fatigue, antioxidation, scavenging free radicals, radioprotective.
To sum up, the advantage of herbal composite of the present invention is:
(1) this herbal composite application Chinese medicine monarch theoretical direction, in conjunction with modern study, adopt multiple Chinese herbal medicine compatibility to extract to form, not only play complementary effect and also greatly reduce and be used alone monarch drug Saussurea medusa Maxim. extracting solution and be applied to stimulation to skin in cosmetics;
(2) this herbal composite adds in cosmetics series as functional additive and can not only play skin care, prevents the too fast aging effect of skin, has the health-care effect of dysmenorrhea effect that pain, impairment caused by overstrain and women's cold womb of dispelling articular rheumatic, prevention and releasing arthritis and causing cause concurrently simultaneously.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described.
Ultrasound wave is a kind of mechanical wave, and effective frequency is generally in 20 ~ 50kHz scope.Ultrasonic extraction is applied in natural product constituents extraction technique by the comprehensive effect such as cavitation, vibration, pulverizing, stirring that ultrasound wave produces, by destroying cell wall, increase solvent penetration power, thus improve extraction ratio and shorten extraction time, reach process that is efficient, rapid extraction cellular content.Ultrasonic extraction does not have an impact to the structure of extract, activity.Following examples 1-3 is the detailed process utilizing supercritical ultrasonics technology step by step arithmetic effective ingredients in plant.
Embodiment 1
Raw material (kg) is taken according to following raw material composition and parts by weight proportioning:
Saussurea medusa Maxim. 40, Rhizoma Drynariae 30, Cacumen Myricariae Germanicae 30, Rhizoma Gymnadeniae 20.
Preparation technology is as follows:
(1) plant of said ratio consumption cleaned up and remove impurity, mix after drying and crushing respectively, put into ultrosonic extractor, the distilled water of 2400kg is added according to the gross weight of Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae melange, in 60 DEG C of ultrasonic extraction method 30 minutes after dipping half an hour, hyperacoustic power is 220W, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) add the ethanol that 3000kg volume fraction is 80% in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor, in 65 DEG C by ultrasonic extraction method 30 minutes, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained herbal composite.
Embodiment 2
Raw material (kg) is taken according to following raw material composition and weight proportion:
Saussurea medusa Maxim. 20, Rhizoma Drynariae 15, Cacumen Myricariae Germanicae 15, Rhizoma Gymnadeniae 12.
Preparation technology is as follows:
(1) plant of said ratio consumption cleaned up and remove impurity, mix after drying and crushing respectively, put into ultrosonic extractor, the distilled water of 620kg is added according to the gross weight of Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae melange, in 45 DEG C of ultrasonic extraction method 40 minutes after dipping half an hour, hyperacoustic power is 100W, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) add the methanol that 1060kg volume fraction is 70% in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor, in 55 DEG C by ultrasonic extraction method 40 minutes, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained herbal composite.
Embodiment 3
Raw material (kg) is taken according to following raw material composition and weight proportion:
Saussurea medusa Maxim. 45, Rhizoma Drynariae 35, Cacumen Myricariae Germanicae 35, Rhizoma Gymnadeniae 30.
Preparation technology is as follows:
(1) plant of said ratio consumption cleaned up and remove impurity, mix after drying and crushing respectively, put into ultrosonic extractor, the distilled water of 4350kg is added according to the gross weight of Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae melange, in 70 DEG C of ultrasonic extraction method 20 minutes after dipping half an hour, hyperacoustic power is 300W, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) add the ethanol that 4920kg volume fraction is 90% in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor, in 75 DEG C by ultrasonic extraction method 20 minutes, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained herbal composite.
Comparative example 1
Raw material (kg) is taken according to following raw material composition and weight proportion:
Saussurea medusa Maxim. 40.
Preparation technology is as follows:
(1) plant of above-mentioned consumption cleaned up and remove impurity, drying and crushing, put into ultrosonic extractor, the distilled water of 800kg is added according to the gross weight of Saussurea medusa Maxim. pulverized product, in 60 DEG C of ultrasonic extraction method 30 minutes after dipping half an hour, hyperacoustic power is 220W, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) add the ethanol that 1020kg volume fraction is 80% in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor, in 65 DEG C by ultrasonic extraction method 30 minutes, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained Saussurea medusa flower extract.
Embodiment 4
Mouse skin irritant test:
Test specimen: the herbal composite of embodiment 1 gained, the Saussurea medusa flower extract of comparative example 1 gained;
Test method: reference (cosmetics health specification) 2007 Ministry of Public Health health legal system and supervision department;
Experimental animal: white mice;
Result of the test: 7 days Skin Irritation Test, uses the herbal composite test group of embodiment 1 gained to have no irritant reaction, uses the Saussurea medusa flower extract matched group some animals of comparative example 1 gained to occur that minimal irritation is reacted.
Table 1 is the formula contrast of a kind of emollient cream of embodiment 5-7 and comparative example 2-3, the herbal composite of herbal composite described in table obtained by embodiment 1, the Saussurea medusa flower extract of Saussurea medusa flower extract obtained by comparative example 1, Components Name is international cosmetic raw material name (International Nomenclature Cosmetic Ingredient, INCI) title of defined, such as caprylic/capric triglyceride, ring five polydimethylsiloxane/cyclohexasiloxane.Concrete component and percentage by weight as follows:
Table 1
Embodiment 8 clinical trial efficacy assessments
(1) test method
Collect 150 20-35 year like wearing vest or medicated underpants skirt at ordinary times and the volunteer working under air conditioner surroundings or live for a long time, cold womb is wherein had to cause the women 50 of dysmenorrhea symptom, there is the male 50 of rheumatoid arthritis symptom, simultaneously with the women 50 of dysmenorrhea symptom and rheumatoid symptom.Trier's living habit is good, and non-smoking, without Long-term taking medicine medical history.Emollient cream obtained by embodiment 5-7 in table 1 and comparative example 2-3 is tried out 6 months continuously through volunteer.
(2) experimental result
Experimental result 1
The skin aging initial stage is that xerosis cutis is coarse, and antiperspirant fat and sebum decline; In earlier stage for skin elasticity relaxes.Main with the soft degree of experimenter's skin of face in this on-test to off-test process, DE and the zest to skin generation are observed as evaluation index.Concrete observed result is in table 2.
The skin care of table 2 product and prevent the observed result of the too fast aging effect of skin
Experimental result 2
Emollient cream that table 3 obtains for embodiment 5-7 and comparative example 2-3 after 50 have the male of rheumatoid arthritis symptom and 50 have the women of rheumatoid arthritis symptom to try out to the improvement degree of arthralgia and to skin produce zest observed result:
Table 3
Experimental result 3
To the improvement degree of arthralgia and the zest observed result to skin generation after emollient cream that table 4 obtains for embodiment 5-7 and comparative example 2-3 has cold womb to cause the women of dysmenorrhea symptom to try out through 100:
Table 4
As can be seen from table 2-table 4 data, no matter add separately Saussurea medusa flower extract group is for skin care, prevent the too fast aging efficacy assessments of skin still for the pain that prevention and releasing arthritis cause, the dysmenorrhea efficacy assessments that impairment caused by overstrain and women's cold womb cause all has obvious effect, and other combined Chinese herbs use skin care, prevent the pain that the too fast aging effect of skin and prevention and releasing arthritis cause, dysmenorrhea effect that impairment caused by overstrain and women's cold womb cause has obvious facilitation, significantly reduce when simultaneously other Chinese herbal medicine are by adding after compatibility and using in cosmetics series and be used alone Saussurea medusa flower extract and add zest to skin when using in cosmetics series.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (9)
1. the herbal composite containing Saussurea medusa Maxim., is characterized in that, its raw material composition and parts by weight proportioning are: Saussurea medusa Maxim. 10-50 part; Rhizoma Drynariae 10-40 part; Cacumen Myricariae Germanicae 10-40 part; Rhizoma Gymnadeniae 8-35 part.
2. herbal composite according to claim 1, is characterized in that, its raw material composition and weight proportion are: Saussurea medusa Maxim. 15-45 part; Rhizoma Drynariae 15-35 part; Cacumen Myricariae Germanicae 15-35 part; Rhizoma Gymnadeniae 13-30 part.
3. herbal composite according to claim 1 and 2, is characterized in that, its raw material composition and weight proportion are: Saussurea medusa Maxim. 40 parts; Rhizoma Drynariae 30 parts; Cacumen Myricariae Germanicae 30 parts; Rhizoma Gymnadeniae 20 parts.
4. the preparation method of the herbal composite according to any one of claim 1-3 comprises the following steps:
(1) get and cleaned up and removed deimpurity Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae, the rear mixing of dry, pulverizing respectively, put into ultrosonic extractor, 10-30 distilled water is doubly added according to the gross weight of Saussurea medusa Maxim., Rhizoma Drynariae, Cacumen Myricariae Germanicae, Rhizoma Gymnadeniae melange, dipping half an hour after in 40-80 DEG C of ultrasonic extraction method 20-40 minute, sucking filtration while hot, 60 DEG C of concentrating under reduced pressure extracting solution;
(2) the hydrophilic Extraction solvent that solid-liquid ratio is 1:10-50 is added in the medicinal residues after above-mentioned filtration, flood 10 minutes, adopt identical ultrosonic extractor in 50-80 DEG C of ultrasonic extraction method 20-40 minute, while hot sucking filtration, 60 DEG C of concentrating under reduced pressure extracting solution;
(3) the extracting solution mixing of gained in step (1) and (2) was both obtained herbal composite.
5. preparation method according to claim 4, is characterized in that, the hydrophilic Extraction solvent described in step (2) is ethanol, methanol, butanediol, propylene glycol or ethyl acetate, and the volume fraction of solvent is 70-90%.
6. preparation method according to claim 4, is characterized in that, described hyperacoustic power is 100-300W.
7. the herbal composite according to any one of claim 1-3 is preparing the application in cosmetics.
8. application according to claim 7, described cosmetics are emollient cream.
9. an emollient cream, is characterized in that, comprises each component of following percentage by weight:
Herbal composite: 2-10wt%,
Emulsifying agent: 3-5wt%,
Thickening agent: 0.1-1wt%,
Emollient: 8-20wt%,
Wetting agent: 5-15wt%,
Antiinflammatory: 0.1-0.6wt%,
PH conditioner: 0.1-0.5wt%,
Transdermal enhancer: 0.5-2wt%,
Antiseptic: 0.2-0.7wt%,
Deionized water: surplus;
Described herbal composite is Chinese herbal medicine combined extracts prepared by claim 4;
Described emulsifying agent is at least one in sorbitan stearate, cetearyl alcohol or PEG-60 Span60;
Described thickening agent is at least one in carbomer, xanthan gum or hydroxyethyl-cellulose;
Described emollient is at least one in polydimethylsiloxane, hydrogenated olive oil, ring five polydimethylsiloxane/cyclohexasiloxane, hydrogenated jojoba oil, caprylic/capric triglyceride or squalane;
Described wetting agent is at least one in glycerol, propylene glycol, hyaluronate sodium, oligofructose;
Described antiinflammatory is at least one in allantoin, glycyrrhizic acid dipotassium;
Described PH conditioner is at least one in potassium hydroxide, triethanolamine;
Described transdermal enhancer is at least one in tetrahydrochysene piperine, azone;
Described antiseptic is at least one in phenoxyethanol, sodium benzoate or 1,2-hexanediol/caprylyl glycol.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410579473.1A CN104288055A (en) | 2014-10-24 | 2014-10-24 | Chinese herbal medicine composition containing saussurea medusa as well as preparation method and application of Chinese herbal medicine composition |
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| CN201410579473.1A CN104288055A (en) | 2014-10-24 | 2014-10-24 | Chinese herbal medicine composition containing saussurea medusa as well as preparation method and application of Chinese herbal medicine composition |
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| CN106943316A (en) * | 2017-05-23 | 2017-07-14 | 广州润虹医药科技有限公司 | Emulsion of skin regeneration and preparation method thereof can be promoted |
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Application publication date: 20150121 |