CN109674890A - The composition and skin care item and preparation method of prevention and/or treatment skin red capillary - Google Patents

The composition and skin care item and preparation method of prevention and/or treatment skin red capillary Download PDF

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CN109674890A
CN109674890A CN201910046092.XA CN201910046092A CN109674890A CN 109674890 A CN109674890 A CN 109674890A CN 201910046092 A CN201910046092 A CN 201910046092A CN 109674890 A CN109674890 A CN 109674890A
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parts
composition
preparation
skin
extract
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CN109674890B (en
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李文渊
童丽
杜雯煜
华梦茹
闫巧
王寒蕾
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Qinghai University
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Qinghai University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses compositions and skin care item of a kind of prevention and/or treatment skin red capillary and preparation method thereof, composition includes 20~50 parts of saussurea medusa flower, 15~30 parts of safflower, 18~30 parts of Radix Astragali, 10~20 parts of lycium ruthenicum and 10~18 parts of myrobalan, the alcohol extracting thing that the present invention passes through the above-mentioned Chinese medicine of extraction, obtain effectively preventing and/or treating the composition of red blood trace on face, and its low irritability is proved by test, it can be widely used for skin care item and drug of preparation prevention and/or treatment red blood trace on face etc..The face cream cure rate of present invention prevention and/or treatment red blood trace on face is high, can also moisturizing beauty, safely and effectively.

Description

The composition and skin care item and preparation method of prevention and/or treatment skin red capillary
Technical field
The present invention relates to Chinese medicine and skin care fields, more particularly to the composition for preventing and/or treating skin red capillary And external preparation.
Background technique
Facial telangiectasias is commonly called as " red capillary ", refers to because facial cuticula weakness causes capillary position more to hold External environment variation is easily contacted and perceives, to cause face phenomenon caused by telangiectasias.
The face of red blood trace on face patient seems redder than general normal skin tone.People often claim plateau face or blush egg or Rotten apple, some are only that cheekbone portion in two sides is rubescent, and boundary is rounded, generally in silk the linear alignment.It is thin and sensitive for skin Face is redder when for people, being subcooled, overheating, is excited.Serious person also will form deposition color spot, it is difficult to cure.It will be apparent that The image that face has red capillary to influence whether patient, especially for the female patient much liked to be beautiful, for this phenomenon certainty Take notice of very much, this not only influences beauty, but also increases the psychological pressure of patient, but existing drug or skin care item have often been difficult to well Curative effect is the trouble of the mind of many patients.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of prevention and/or the compositions and shield for the treatment of skin red capillary Skin product and preparation method thereof can effectively make the facial telangiectasias of patient subside, and sensitization is low.
In traditional Chinese medical science field, red capillary, which is called, does " crimson face ", main cause are as follows: cardiopulmonary are hot and suffocating, hematogenous blockage, painstaking effort supply Failure of skin and muscle to be nourished caused by the insufficient and train of thought stasis of blood is stagnant, needs to be improved and changed with the time, by the treatment method of Chinese medicine often than west Medicine is safer and more effective, and will not generate dependence.
In order to solve the above technical problems, one technical scheme adopted by the invention is that:
A kind of composition is provided, raw material includes the component of following parts by weight meter: 20~50 parts of saussurea medusa flower, safflower 15 ~30 parts, 18~30 parts of Radix Astragali, 10~20 parts of lycium ruthenicum and 10~18 parts of myrobalan.
The preparation method of above-mentioned composition, including following content:
(1) saussurea medusa flower is taken；(2) safflower is taken；(3) Radix Astragali is taken；(4) lycium ruthenicum is taken；(5) myrobalan is taken；(6) alcohol extracting.
Wherein, any one of (1)~(5) or two or more can combine with (6), it can include but is not limited to as follows Combining form:
A, (1)~(5), respectively alcohol extracting are independently taken；
B, alcohol extracting after at least two combinations in (1)~(5), remainder in (1)~(5) can alone or in combination after Alcohol extracting；For example, taking saussurea medusa flower and safflower, alcohol extracting, Radix Astragali, lycium ruthenicum, myrobalan individually alcohol extracting are mixed；Alternatively, taking Huang Stilbene and myrobalan, mix alcohol extracting, and saussurea medusa flower, safflower and lycium ruthenicum three mix alcohol extracting, etc..
Certainly, above-mentioned preparation method can also be including one or more behaviour in conventional degreasing, mixing, concentration, drying Make, can be added according to actual needs with reference to conventional method in that art.
Further, the composition material includes the component of following parts by weight meter: Saussurea medusa flower extract 18~45 Part, 13~26.5 parts of safflower extract, 15~26.5 parts of Astragalus Root P.E, 8.5~18 parts of lycium ruthenicum extract and myrobalan extract 8.5~15.5 parts of object.
Saussurea medusa flower of the present invention selects the drying herb of compositae plant saussurea medusa flower, and the medicine is common for middle Tibetan medicine Medicinal material, sweet-bitter flavor is warm-natured, can activating microcirculation and removing stasis medicinal, more head wound；Modern medicine study proves, flavones is contained in lanatechead saussurea herb with flower, biology Alkali, the effective components such as polysaccharide, thus it is with anti-inflammatory, and it is anti-radiation, remove the biological function of free radical.
Safflower of the present invention selects the dry flower of compositae plant safflower, and safflower is warm-natured, and nontoxic, activating microcirculation and removing stasis medicinal, promoting menstruation stops Bitterly；Modern medical research has found that containing flavones in red, the antioxidant contents such as vitamin E can play certain defence to skin aging Effect, moreover it is possible to activating microcirculation and removing stasis medicinal.
Radix Astragali of the present invention selects the dry root of leguminous plant Radix Astragali, Radix Astragali slightly warm in nature, nontoxic, tonifying middle-Jiao and Qi, to mend The length of medicine；Modern medicine study proves that flavones in Radix Astragali, polysaccharide component content is higher, thus it has stronger anti-aging, resists Oxidation and tonifying Qi effect.
Lycium ruthenicum of the present invention selects the dry mature fruit of plant of Solanaceae lycium ruthenicum, is widely used in Tibetan medicine, black Fructus lycii is warm-natured, nontoxic, delaying sanility, treatment cardiovascular disease etc.；Modern study proves that lycium ruthenicum crowd contains a large amount of flavones, with And the ingredients such as procyanidine, the above ingredient are most effective natural free radical scavenger, can delaying skin histocyte aging, Increase capillary elasticity.
Myrobalan of the present invention selects the dry mature fruit of combretaceae myrobalan, is traditional Tibetan medicine's medicinal material, He Zixing Tepor, it is nontoxic, restrain sending down abnormally ascending, the puckery intestines of astringing lung-QI；Modern medicine study proves that flavones in myrobalan, tannic acid constituents are in the majority, tannins It can inhibit histamine decarboxylase.
Present invention combination Basic Theories of Chinese Medicine and doctor trained in Western medicine modern pharmacological research carry out selecting medicine as guidance foundation, select above-mentioned The composition selection Radix Astragali of drug composition selects drug for invigorating blood circulation and eliminating stasis safflower to qi-supplementing, blood-engendering, fundamentally solves red blood The pathogenesis of silk cooperates with the saussurea medusa flower in composition, lycium ruthenicum, myrobalan, plays synergistic effect, shrinkable expansion The capillary opened, and apparent repair is played to the red blood trace on face formed by extravasated blood, it is effectively improved the face of patient Red capillary phenomenon.
Further, the extract is alcohol extracting thing.The alcohol extracting thing includes but is not limited to methanolic extract, second Alcohol extracting thing, propyl alcohol extract, n-butanol extract.
The present invention also provides the preparation methods of above-mentioned composition, including the following steps:
(1) preparation of each raw medicinal material extract: after respectively crushing each raw medicinal material, after degreasing, alcohol extracting takes alcohol extracting Liquid is concentrated, is drying to obtain each raw medicinal material extract；
(2) each raw medicinal material extract made from step (1) is mixed to obtain the final product.
In a specific embodiment of the present invention, alcohol extracting is using ultrasonic extraction, using the cavitation of ultrasonic wave, machine Tool effect and fuel factor accelerate the dissolution of intracellular active principle, improve extraction efficiency.
The present invention also provides purposes of the above-mentioned composition in the product of preparation prevention and/or treatment skin red capillary.
Further, the product is external preparation.The including but not limited to skin care item of external preparation for skin, drug, health care product Deng.
The present invention also provides a kind of prevention and/or the products for the treatment of skin red capillary, include above-mentioned any composition.
Further, the product is skin care item or external preparation for skin drug.
The skin care item or external preparation for skin drug include composition of the present invention or in which active constituent, and makeup Product field, the acceptable auxiliary material of medical domain may also include the active principle with other treatment function certainly.
The present invention also provides a kind of prevention and/or the skin care item for the treatment of skin red capillary, and raw material includes following weight hundred The component of point ratio: above-mentioned any composition 10~15%, carbomer 0.5~1.0%, chamomile hydrosol 1.0~2.0%, Hyaluronic acid 0.01~0.05%, glycerol 2.5~3.0%, butanediol 0.5~1.0%, triethanolamine 0.5~1.0%, nerve Amide 0.01~0.06%, shea butter 2.0~3.0%, glycerin monostearate 1.5~2.5%, grape seed oil 1.0~ 2.0%, jojoba oil 1.0~2.0%, saualane 0.1~0.5%, tea tree ethereal oil 0.5~1.0%, Rosa Damascana 0.01~ 0.05%, surplus is deionized water.
The present invention provides the preparation methods of above-mentioned skin care item, including following content:
(1) carbomer, chamomile hydrosol, hyaluronic acid, glycerol, butanediol, ceramide, triethanolamine and deionization Water heats to obtain mixture A；
(2) by shea butter, glycerin monostearate, grape seed oil, jojoba oil and saualane, mixture B is heated to obtain；
(3) mixture B is added in mixture A, emulsifying obtains emulsion；
(4) by gained emulsion, mixed with tea tree ethereal oil, Rosa Damascana and composition, homogeneous to get.
Since there are volatility for essential oil, when essential oil is added, in order to avoid essential oil volatilizing loss caused by high temperature, Ke Yishi When the temperature for adjusting emulsion.For example, in a specific embodiment of the invention, using in 50 DEG C or so addition essential oils, certainly, It is also possible to other temperature, including but not limited to 40 DEG C, 45 DEG C etc..The selection of temperature, as long as can be avoided essential oil volatilization, together When guarantee be uniformly mixed.
The beneficial effects of the present invention are:
(1) capillary of the shrinkable expansion of the present composition, the capillary of shrinkage expansion, activating microcirculation and removing stasis medicinal, opposite Portion's red capillary can play apparent repair, and sensitization is low, highly-safe, can be used for preparing prevention and/or treatment skin is red The skin care item or drug of the trace of blood.
(2) present composition preparation process simple possible, can effectively obtain for it is subsequent prepare skin care item or drug when The composition of the treatment red blood trace on face used.
(3) face cream of the present invention is high for patient's cure rate of red blood trace on face, significant effect, and sensitization is low, safety Property it is high.
Specific embodiment
The preparation of 1 Chinese medical extract of embodiment
The preparation of Saussurea medusa flower extract:
Medicinal material is first crushed, then uses ether defatting, removes oil-soluble impurities, then the methanol for being 50% with mass fraction It is rear to be centrifuged in 50 DEG C of ultrasonic extraction 1h, filtering；Filtrate is concentrated with Rotary Evaporators, after concentrate is evaporated, be crushed into powder, Obtain saussurea medusa flower extract powder, yield 90%.
The preparation of safflower extract or Astragalus Root P.E:
Medicinal material is first crushed, then uses ether defatting, removes oil-soluble impurities, then the methanol for being 75% with mass fraction In 75 DEG C of ultrasonic extraction 1h, filtering；Filtrate is concentrated with Rotary Evaporators, after concentrate is evaporated, be crushed into powder, obtain safflower Extract powder (yield 87%) or Astragalus Root P.E powder (yield 87%).
The preparation of lycium ruthenicum extract:
Medicinal material is first crushed, then uses ether defatting, removes oil-soluble impurities, then the methanol for being 60% with mass fraction In 50 DEG C of ultrasonic extraction 25min, filtering；Filtrate is concentrated with Rotary Evaporators, after concentrate is evaporated, be crushed into powder, obtain Lycium ruthenicum extract powder, yield 89%.
The preparation of Fructus Chebulae extract:
Medicinal material is first crushed, then uses ether defatting, removes oil-soluble impurities, then the methanol for being 30% with mass fraction In 50 DEG C of ultrasonic extraction 1h, filtering；Filtrate is concentrated with Rotary Evaporators, after concentrate is evaporated, be crushed into powder, obtain myrobalan Extract powder, yield 86%.
Corresponding extraction is made by the method for embodiment 1 to application amount raw material using each group of H~L group in table 1 respectively Object remixes to obtain each group composition of the present invention.
Table 1
H I J K L
Saussurea medusa flower (g) 25 30 20 36 42
Safflower (g) 22 22 25 19 16
Radix Astragali (g) 22 18 27 20 18
Lycium ruthenicum (g) 15 18 18 14 10
Myrobalan (g) 16 12 10 11 14
Embodiment 2
Face cream square foundation of the present invention by forming following weight percentage components:
Carbomer 0.5~1.0%, chamomile hydrosol 1.0~2.0%, hyaluronic acid 0.01~0.05%, glycerol 2.5~ 3.0%, butanediol 0.5~1.0%, triethanolamine 0.5~1.0%, ceramide 0.01~0.05%, shea butter 2.0~ 3.0%, glycerin monostearate 1.5~2.5%, grape seed oil 1.0~2.0%, jojoba oil 1.0~2.0%, saualane 0.1~0.5%, tea tree ethereal oil 0.5~1.0%, Rosa Damascana 0.01~0.05% is supplemented to 100% with deionized water.
Moisture retention detection is carried out to the skin care basis frost of the square foundation of different ratio, selects the square foundation of optimum proportioning:
Using the aquation of 200 type keratoderma water content measuring instrument of SKICON test skin, its measuring principle It is to contain a large amount of electrolyte due to cuticula, the electrolyte deposited in water is conductive, and this phenomenon is also generated in skin table Face, by test probe with after skin contact, conductivity changes to react the hydration status of skin.
Subject is health without dermopathic women, and experiment condition requires the temperature and humidity of environment permanent during being test Fixed, temperature is 20 DEG C ± 2 DEG C, and relative humidity is 30%~60%.Test sample are as follows: (1) present invention 1.~5. group without combination The skin care basis frost of object；(2) 10% glycerol face cream are as marker.Testing result is shown in Table 2.
Wherein, 1.~5. organize each component in basic face cream match such as table 2:
Table 2
Skin care basis frost the preparation method comprises the following steps: raw material each in A phase is mixed, be heated to 75 DEG C, keep the temperature 15 minutes；By B phase In the mixing of each raw material, be heated to 85 DEG C, keep the temperature 25 minutes.B phase raw material is slowly added in A phase, emulsifying 20 minutes.It is cooling C, D phase raw material are sequentially added when to 50 DEG C, continue homogeneous 15 minutes to get skin care basis frost.
Performance of keeping humidity test method are as follows: (1) determine that left and right forearm test zone, region area are 5cm × 5cm, survey respectively Try the blank value in the region.(2) 10% glycerol face cream is applied to a region is reference sample, and face cream of the present invention is smeared In another region be test article, dosage 2mg/cm2.(3) rear 30min is used, 60min, 120min are tested, test 3~4 It is a, its conductivity is recorded respectively and is averaged, and the results are shown in Table 3.
Table 3 using glycerol face cream or 1.~5. the white skin electric conductivity in group skin care basis compare
From above-mentioned experimental result can be seen that the present invention 1.~5. group skin care basis frost and the conductivity of 10% glycerol face cream Variation is close, and illustrates that it, with preferable performance of keeping humidity, wherein the performance of keeping humidity 4. organized is best, is determined as skin care of the invention The optimum proportioning square foundation of basic frost.
Using best square foundation prepare respectively it is as shown in table 4 it is of the invention 6.~8. organize face cream, wherein composition is equal Use composition K:
Table 4
Face cream of the present invention the preparation method comprises the following steps: raw material each in A phase is mixed, be heated to 75 DEG C, keep the temperature 15 minutes；By B Each raw material mixing, is heated to 85 DEG C, keeps the temperature 25 minutes in phase.B phase raw material is slowly added in A phase, emulsifying 20 minutes.It is cold C, D, E phase raw material are sequentially added when but to 50 DEG C, continue homogeneous 15 minutes to get face cream of the present invention.
By the present invention 6.~8. group face cream with above-mentioned identical method test its moisture retention, test result is shown in Table 5.
Table 5 using it is of the invention 6.~skin electric conductivity of 8. organizing face cream changes
Time ⑥(uv) ⑦(uv) ⑧(uv)
0min 358 355 358
30min 118 121 120
60min 86 88 89
120min 54 55 55
By above-mentioned experimental result it is found that the performance of keeping humidity of face cream of the invention is compared with no composition after composition is added Skin care basis frost it is more preferable, after illustrating that the present composition is added, played synergistic effect with the other components of face cream, enhancing The performance of keeping humidity of face cream.It can also be seen that the dosage of composition changes the moisturizing to face cream of the present invention from above-mentioned data Performance influences less, final selected the 8. organize face cream component proportion be face cream of the present invention optimum proportioning.
Prove the present composition and face cream for the therapeutic effect and safety of red capillary below by test example.
1 hypersensitive experimental study of test example
By zoopery, to observe sensitization of the face cream to guinea pig skin for the treatment of red blood trace on face of the invention. The face cream of the composition of group containing K for the preparation method preparation that face cream used in this test is through the embodiment of the present invention 2 (is matched Than 8. organizing face cream optimum proportioning for the).
Regular grade cavy 50 are selected, half male and half female, during 180~250g, test, room temperature is controlled 20 body weight control DEG C -22 DEG C, humidity 40%~67%, light and shade replaces illumination 12h/12h round the clock.Cavy is dyed by number, it is bitter with saturation Sour (yellow) solution dye marker units marks tens with 2% silver nitrate solution (coffee color)；It is separately raised by gender It supports, each cage box puts five cavys, labelled outside cage box, identify animal category, gender, administration route, number of animals, and Test the information such as date.
According to national " drug registration management method ", " Chemical induced irritation, anaphylaxis and the guidance of hemolytic investigative technique Principle ".It is randomly divided into bare substrate group, positive controls, pharmaceutical composition group.Wherein 10 cavys of bare substrate group, remaining Two groups of each 20 cavys, every group of cavy half male and half female.It successively carries out induction sensitization and excites contact test, between two experiments first 10 days elution phases are carried out afterwards.Induction exposure test method is preceding preserved skin for 24 hours, subtracts the region each two sides 2cm × 2cm of cavy backbone Coat.
Positive controls: taking the acetone soln 0.2g of 2.5%2,4- dinitro-chloro-benzene, respectively with two layers of gauze (2.5cm × 2.5cm) and one layer of antistaling film covering, 6h is covered with non-stimulated gauze, removes covering, removes residual test sample with warm water Product the 7th day and the 14th day, are in kind repeated once.Bare substrate (physiology salt is applied in bare substrate group animal same area Water) 0.1g, test group applies face cream 0.1g of the present invention, by the progress induction experiment of same step.
Excitation contact was carried on the back to 14 days after tested material sensitization contact (testing the 28th day) in test group cavy in last Coat the face cream of the present invention of 0.1g at portion's butt, package and fixation are removed tested material after 6h, are observed at once, then in for 24 hours, 48h, 72h observe skin allergy situation again.The acetone soln 0.2g of positive controls 2.5%2,4- dinitro-chloro-benzene, Bare substrate group animal same area apply bare substrate 0.1g, after sensitization 1h, for 24 hours and excitation after for 24 hours, 48h, 72h observe to Medicine erythema, oedema and other abnormal responses.It scores by cutaneous anaphylaxis standards of grading erythema and oedema, And the allergic reaction incidence of each group is calculated, allergic reaction occurrence degree is judged by cutaneous anaphylaxis standards of grading.Allergy is anti- Answer incidence=(occurring number of animals/this group of animal number of erythema, oedema or systemic anaphylaxis in group) × 100%.
Excite contact test after for 24 hours, 48h, 72h, according to " Chemical induced irritation, anaphylaxis and hemolytic investigative technique Guideline " judge cutaneous anaphylaxis whether occur, sensitivity response >=2 timesharing of scoring determine the animal skin sensitivity response The positive calculates sensitization rate (>=2 points of number of animals/this group of number of animals × 100%), and by " Chemical induced irritation, anaphylaxis and molten Hemorrhagic investigative technique guideline " in sensitization of skin reaction experiment grade scale determine cause of the present composition to guinea pig skin Quick intensity.Sensitization of skin extent of reaction standards of grading are shown in Table 4, and sensitization of skin extent of reaction grade scale is shown in Table 5, and test result is shown in Table 6.
4 sensitization of skin extent of reaction standards of grading of table
5 sensitization of skin extent of reaction grade scale of table
6 pharmaceutical composition guinea pig skin allergic reaction of table evaluation
From the above results, all there is erythema, allergy in 6h after excitation, positive controls group cavy excitation area skin Reacting incidence is 100%, and allergic reaction is evaluated as extremely strong sensitization.48h after excitation, positive controls cavy excite area skin Still all there is erythema, allergic reaction incidence is 100%, and allergic reaction evaluation is still extremely strong sensitization.
And for bare substrate group and test group, excitation for 24 hours, after 48h, 72h, bare substrate group, test group cavy swash Hair area skin does not occur erythema, oedema situation, does not occur other abnormal responses, allergic reaction incidence is 0, allergy yet Reaction evaluating is to have no cutaneous anaphylaxis.
It is above-mentioned experiments have shown that, face cream sensitization of the present invention containing composition is low, highly-safe, can promote the use of.
2 face cream measure of merit of test example
In following tests, composition that the face cream that uses is H~L group made from embodiment 1 is treated according to embodiment 2 the 8. the face cream for optimum proportioning and the method preparation organized.
Red blood trace on face Patients with 300 Cases is selected, is women, it is the age 22~41 years old, 35 years old, the course of disease 1 year~15 years average. Skin damage is mainly non-essential telangiectasia patient in cheekbone portion, cheek and wing of nose two sides.Wherein cosmetics make With improper 82, aesthetic nursing improper 75, external skin drug-induced person 58, the sunshine person of causing 85, but without obvious skin Skin atrophy, did not did laser, and the treatment such as living cells therapy is randomly divided into 6 groups (5 groups for the treatment of group, 1 group of control groups), 6 groups Gender, age, state of an illness aspect no significant difference.
Treatment group: using face cream of the invention, and creme is applied at facial sweater blood vessel dilatation after cleaning face, 3 times/day.Control group: with the 4. group skin care basis frost be applied at facial telangiectasias according to the above method, 3 times/day.It controls Curative effect is observed after treating 60 days, is evaluated.It the results are shown in Table 7, wherein group H, the face cream for indicating that this group of patient uses contain Composition be a kind of H group of embodiment composition, I, J, K, L group are similarly.
Parameters for observation on effect and standards of grading: objective sign: the improvement standard of facial capillary is divided into 4 grades: recovery from illness: hair Thin blood vessel dilatation, which is subsided, reaches 90%-100%；Effective: telangiectasis, which is subsided, reaches 70%-89%；It is effective: telangiectasis Recession 30%-69%；Invalid: telangiectasis is subsided below 30% or without significant change.
7 patient's objective sign of table improves situation
Above-mentioned test result show without the present composition the 4. group skin care basis frost it is effective to the improvement of red capillary Rate is low, and face cream of the present invention can effectively improve the clinical symptoms of red blood trace on face patient, can make the blood capillary of patient facial region Enlargement of pipe is subsided, and has significant therapeutic effect to red blood trace on face, wherein the face cream of the composition containing K group of the present invention Curative effect is most prominent, is suitble to promote the face cream prepared with the component of the formula for preventing and/or treating red blood trace on face.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims (10)

1. a kind of composition, which is characterized in that its raw material includes the component of following parts by weight meter: 20~50 parts of saussurea medusa flower, 15~30 parts of safflower, 18~30 parts of Radix Astragali, 10~20 parts of lycium ruthenicum and 10~18 parts of myrobalan.
2. the preparation method of composition described in claim 1, it is characterised in that: it includes following content:
(1) saussurea medusa flower is taken；(2) safflower is taken；(3) Radix Astragali is taken；(4) lycium ruthenicum is taken；(5) myrobalan is taken；(6) alcohol extracting.
3. a kind of composition, which is characterized in that its raw material includes the component of following parts by weight meter: Saussurea medusa flower extract 18~ 45 parts, 13~26.5 parts of safflower extract, 15~26.5 parts of Astragalus Root P.E, 8.5~18 parts of lycium ruthenicum extract and myrobalan mention Take 8.5~15.5 parts of object.
4. composition as claimed in claim 3, which is characterized in that the extract is alcohol extracting thing.
5. the preparation method of composition as claimed in claim 4, characterized in that it comprises the following steps:
(1) preparation of each raw medicinal material extract: after respectively crushing each raw medicinal material, after degreasing, alcohol extracting takes alcohol extract, dense It contracts, be drying to obtain each raw medicinal material extract；
(2) each raw medicinal material extract made from step (1) is mixed to obtain the final product.
6. composition described in any one of claim 1,3,4 is in the product of preparation prevention and/or treatment skin red capillary Purposes；Further, the product is external preparation.
7. the product of a kind of prevention and/or treatment skin red capillary, which is characterized in that include any one of claim 1,3,4 institute State composition.
8. product according to claim 7, which is characterized in that the product is skin care item or external preparation for skin drug.
9. the skin care item of a kind of prevention and/or treatment skin red capillary, which is characterized in that its raw material includes following weight percent Component: composition 10~15% described in any one of claim 1,3,4, carbomer 0.5~1.0%, chamomile hydrosol 1.0 ~2.0%, hyaluronic acid 0.01~0.05%, glycerol 2.5~3.0%, butanediol 0.5~1.0%, triethanolamine 0.5~ 1.0%, ceramide 0.01~0.06%, shea butter 2.0~3.0%, glycerin monostearate 1.5~2.5%, grape pip Oily 1.0~2.0%, jojoba oil 1.0~2.0%, saualane 0.1~0.5%, tea tree ethereal oil 0.5~1.0%, Rosa Damascana 0.01~0.05%, surplus is deionized water.
10. the preparation method of skin care item as claimed in claim 9, which is characterized in that including following content:
(1) carbomer, chamomile hydrosol, hyaluronic acid, glycerol, butanediol, ceramide, triethanolamine and deionized water, add It is hot to obtain mixture A；
(2) by shea butter, glycerin monostearate, grape seed oil, jojoba oil and saualane, mixture B is heated to obtain；
(3) mixture B is added in mixture A, emulsifying obtains emulsion；
(4) by gained emulsion, mixed with tea tree ethereal oil, Rosa Damascana and composition, homogeneous to get.
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