CN106362053A - Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition - Google Patents

Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition Download PDF

Info

Publication number
CN106362053A
CN106362053A CN201610952013.8A CN201610952013A CN106362053A CN 106362053 A CN106362053 A CN 106362053A CN 201610952013 A CN201610952013 A CN 201610952013A CN 106362053 A CN106362053 A CN 106362053A
Authority
CN
China
Prior art keywords
skin
red blood
function
external
blood streak
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610952013.8A
Other languages
Chinese (zh)
Inventor
张丽云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Huizhou Hui Yi Beauty Biotechnology Co Ltd
Original Assignee
Huizhou Hui Yi Beauty Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huizhou Hui Yi Beauty Biotechnology Co Ltd filed Critical Huizhou Hui Yi Beauty Biotechnology Co Ltd
Priority to CN201610952013.8A priority Critical patent/CN106362053A/en
Priority to PCT/CN2016/105803 priority patent/WO2018082117A1/en
Publication of CN106362053A publication Critical patent/CN106362053A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic

Abstract

The invention belongs to the field of cosmetics, and particularly relates to an externally-applied traditional Chinese medicine composition with a function of removing couperose skin, a skin-care preparation and a preparation method thereof. The externally-applied traditional Chinese medicine composition is prepared by combining eleven traditional Chinese medicines of safflower, radix angelicae sinensis, milkvetch roots, ganoderma, pericarp of fragrant citrus, perilla frutescens, asiatic pennywort herb, glabrous greenbrier rhizomes, rhizoma atractylodis macrocephalae, herba opuntiae and rhizoma cimicifugae, and it is verified that the composition has no stimulation to skin. The eleven plant ingredients are matched for use to promote facial micro-circulation, dredge extravasated blood in damaged blood capillaries of the couperose skin, inhibit problems such as redness, swelling and pain, caused by inflammatory factors, of the couperose skin, strengthening the barrier function of the skin, repair the skin epidermis layer and the damaged blood capillaries and completely remove the couperose skin.

Description

There is the external medicine composition dispelling skin red blood streak function and its skin care formulation
Technical field
The invention belongs to cosmetic skin field is and in particular to a kind of have the external application Chinese medicine dispelling skin red blood streak function Compositionss and the skin care formulation containing this Chinese medicine composition.
Background technology
The complex genesis of red blood trace on face are various, mainly include constitutional and two kinds of situations of Secondary cases.Red blood streak patient face Portion looks redder than the normally colour of skin, and people are frequently referred to " plateau is red " or " egg of blushing ".This skin is thin and sensitive, mistake When cold, overheated, excited, face is redder.Severe patient also can form appositional pattern mottle, not only affect the beauty of appearance, also can give Psychology causes shade, to bringing great inconvenience orthobiosiss.
Red blood streak is caused by various impairment factors mostly, and the epidermal area of skin does not have blood capillary, epidermal area Cytotrophy be mainly derived from the third layer spinous layer of our skin epidermis.When acantholysis cell is impaired, itself supply nutrients help Power declines, and skin itself possesses repair ability, and at this moment the blood capillary of skin corium is to help acantholysis cell to provide nutrition, from Master expands, upwards thus forming red blood streak.
At present, processing facial telangiectatic method mainly has liquid nitrogen cryotherapy, photon therapy and laser therapy. , mainly for the lighter situation of telangiectasis, the method effect is not thorough for liquid nitrogen cryotherapy, may leave inequality simultaneously Even speckle.Photon therapy and laser therapy have to professional very strong personnel to operate, the blood capillary of fully erased expansion Pipe, injures skin epidermis, thinning of skin can be made sensitive, simultaneously if cicatrical body constitution, can cause the rubescent damage of large area, Form cicatrix, and with pigmentation and skin damage situations.
The more than skin epidermis of red blood streak skin damage, also blood capillary, so repairing red blood streak skin completely, Need to repair damaged skin epidermal area and repair impaired blood capillary to carry out simultaneously, could fundamentally remove red blood streak.Commercially available For dispelling the skin care item of red blood streak, most is to repair skin epidermis, seldom has the skin care item repairing blood capillary, so Most skin care item can not really solve the problems, such as red blood streak.
Content of the invention
The technical problem to be solved is to provide a kind of natural gentle no any irritating draft skin care formulation, This skin care formulation from allowing skin health angle design formula, the health metabolism of plant component aid in skin, balance skin oil and water ratio Example, while dispelling red blood streak, skin integrally can return to healthy naturalness originally, does not have secondary injury to skin.User Can voluntarily operate using without professional.Damaged skin epidermal area is repaired in different plant component collocation, repairs impaired capillary Blood vessel, dispels red blood streak from root and does not recur.
The technical problem to be solved is achieved by the following technical programs:
A kind of have the external medicine composition dispelling skin red blood streak function, is grouped into by the group of following weight:
20～30 parts of Flos Carthami, 20～30 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Astragali, 20～30 parts of Ganoderma, 5～10 parts of Pericarpium Citri junoriss, Folium Perillae 1～10 Part, 20～50 parts of Herba Centellae, 0.5～5 part of Rhizoma Smilacis Glabrae, 0.1～10 part of the Rhizoma Atractylodis Macrocephalae, 5～10 parts of Radix et Caulis Opuntiae Dillenii, 1～10 part of Rhizoma Cimicifugae.
In above-mentioned composition, Flos Carthami can dredge the congestion in the blood capillary of red blood streak skin expansion, alleviates red blood streak Symptom of erythema, repairs impaired blood capillary.
The ferulic acid containing in Radix Angelicae Sinensis, can suppress hematoblastic gathering effectively.Radix Angelicae Sinensis polysaccharide is made by increase simultaneously The proliferation and differentiation of hemocytoblast and improve hematopoieticmicroenviron-ment, alleviates the quick-fried red hot situation that red blood streak skin easily occurs, recovers Impaired capillary wall elasticity.
Astragalus polysaccharidess, as biomacromolecule composition, play different immunoregulatory activities, these immunoregulation effects Red blood streak scytitiss situation can be nursed one's health, effectively alleviate red blood streak skin face inflammation, reduce red blood streak skin wound not Suitable sense.
Ganoderma equally can promote to circulate, and mitigates red blood streak skin facial pressure.
Herba Centellae repairs epidermal area effect significantly, can promote collagen regeneration.Herba Centellae active component can accelerate wound Healing, can be obviously improved the intensity that draws high of tissue, promote keratinization, and stimulate reticuloendothelial fast-growth, promote into The expression of fibroblast growth factor albumen, thus repair impaired epidermal area.
Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, the active component in Radix et Caulis Opuntiae Dillenii, there is moisturizing and releive, alleviate sensitive red blood streak dermatitises Disease acts on, and strengthens skin barrier simultaneously, repairs skin epidermis, suppresses red blood streak skin histamine release.
Above external medicine composition, each contains the active components of plants of uniqueness, and science is arranged in pairs or groups each composition Ratio, synergism.Start with from red blood streak Crack cause, repair red blood streak skin damage epidermal area, repair red blood streak skin simultaneously The impaired blood capillary of skin, different plant components are directed to red blood streak skin different symptoms, thoroughly solve red blood streak puzzlement.
Further, described external medicine composition preparation method step is as follows:
(1) weight as described in above-mentioned formula weighs crude drug；
(2) crude drug is put in water and decocts water extraction twice, for the first time part by weight 1:15～1 of the crude drug of extraction and water: 40, decocting time is 60～180min, obtains extracting solution, and first time is extracted gained extracting solution and leaches, and filtering residue adds to be filtered relatively The water that 20 ~ 60 times of slag weight is decocted, and decocting time obtains extracting solution for 60～120min, merges extracting solution twice and obtains external Chinese medicine composition crude extract；
(3) cool down crude extract to 22 ~ 28 DEG C, the filter cloth using 100～200 mesh is filtered, in the filtrate obtaining, as external Drug composition.
A kind of skin care formulation containing above-mentioned external medicine composition, by above-mentioned external medicine composition and skin care item adjuvant Composition.
This skin care formulation is grouped into by the group of following percentage by weight:
0.01～5% oligopeptide
0.1～2% allantoin
0.01～1% ceramide
1～10% butanediol
1～5% glycerol
0.5～3% lecithin
1～5% emulsifying agent
0.01～1% hyaluronate sodium
5～25% external medicine composition
2～5% safflower oil
2～5% Jojoba oil
It is supplemented to 100% with water.
Further, described oligopeptide is oligopeptide -1, oligopeptide -3, oligopeptide -5, at least one in oligopeptide -6.Oligopeptide can be straight Connect and be absorbed by the skin, enter epidermal layer cells, repair the collagen fiber of red blood streak skin damage, strengthen skin elasticity, reparation is subject to Damage epidermal area.The less oligopeptide of molecular weight more readily permeable entrance skin, is absorbed by the skin, the preferred oligopeptide of the present invention be oligopeptide- 1.
Further, described ceramide is, Cer EOS, Cer NS, ceramide 3, in Cer AP extremely Few one kind.Ceramide equally has the effect repairing red blood streak skin damage epidermal area.
Further, the preferred sorbitan stearate of described emulsifying agent, sorbitan laurate, sucrose cocounut oil acid esters, Dicetyl phosphate, stereth 2, stereth 21, at least one in ceteth -10 phosphate ester.These Because having special hlb value, the Proportionality design of science can form the liquid crystal structure of uniqueness, interior parcel external application Chinese medicine to emulsifying agent Compositionss, form microcrystalline state.The microcrystalline state being formed, has good affinity with human body cell, can smoothly pass through thin After birth, the external medicine composition of parcel is delivered directly to cell interior, improves absorption efficiency, also contributes to red blood simultaneously Silk effect.
Further, the micromolecule hyaluronic acid sodium of described hyaluronate sodium, preferably different molecular weight, middle molecule hyalomitome Sour sodium, the collocation of polymer hyaluronic acid sodium uses, and can be applied to the different position of skin, promotes skin health.
Further, described skin care formulation is cream, or emulsion or skin cream.
The invention has the following beneficial effects:
The present invention starts with from the reason red blood streak forms most basic, and science is arranged in pairs or groups the ratio of each Chinese medicine ingredients, synergism. Repair red blood streak skin damage epidermal area, recover the skin natural cover for defense, repair red blood streak skin damage blood capillary, from root simultaneously Originally it is to remove red blood streak.Flos Carthami, Radix Angelicae Sinensis, the Radix Astragali, Ganoderma promotes facial microcirculation, dredges the congestion in impaired blood capillary, subtracts Gently red blood is skin facial pressure, repairs impaired blood capillary.Herba Centellae repairs epidermal area effect significantly, can promote collagen again Raw, be obviously improved tissue draws high intensity, thus repairing impaired epidermal area.Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, the activity in Radix et Caulis Opuntiae Dillenii Composition, has moisturizing and releives, and alleviates sensitive red blood streak scytitiss effect, strengthens skin barrier simultaneously, repair skin epidermis, Suppression red blood streak skin histamine release, thoroughly solves red blood streak puzzlement.
Specific embodiment
With reference to embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention, It is not limitation of the invention.
Prepared by external medicine composition:
(1) weigh crude drug by weight: 25 parts of Flos Carthami, 25 parts of Radix Angelicae Sinensis, 10 parts of the Radix Astragali, 20 parts of Ganoderma, 5 parts of Pericarpium Citri junoriss, Folium Perillae 3 Part, 30 parts of Herba Centellae, 1 part of Rhizoma Smilacis Glabrae, 0.1 part of the Rhizoma Atractylodis Macrocephalae, 5 parts of Radix et Caulis Opuntiae Dillenii, 5 parts of Rhizoma Cimicifugae；
(2) crude drug is put in water and decocts water extraction twice, the crude drug of extraction and the part by weight 1:40 of water, decoct for the first time Time is 180min, obtains extracting solution after filtration, and filtering residue carries out second extraction, and filtering residue is 1:30 with the part by weight of water, Decocting time obtains extracting solution for 120min, is filtrated to get second extracting solution, merges extracting solution twice and obtains external application Chinese medicine combination Thing crude extract；
(3) cool down crude extract to 25 DEG C, the filter cloth using 150 mesh is filtered, the filtrate obtaining, as external application Chinese medicine are combined Thing.
Table 1: embodiment 1,2,3 cream formula composition
Cream preparation technology is as follows:
(1) it is divided into aqueous phase and oil phase by every kind of component water soluble nature.
Aqueous phase: water, allantoin, ceramide, butanediol, glycerol, oligopeptide, hyaluronate sodium, external medicine composition
Oil phase: lecithin, emulsifying agent, safflower oil, Jojoba oil
(2) it is initially charged the water of formula proportion in preparing container, be then turned on stirring, by allantoin, ceramide, butanediol, Glycerol, oligopeptide, hyaluronate sodium is homogeneously dispersed in water, stirs 30min.
(3), after stirring 30min, open heating, temperature not can exceed that 60 DEG C, stir 30min.
(4) by each for oil phase component mix homogeneously, it is slowly heated to 60 DEG C, stir standby.
(5) oil phase is added in aqueous phase, starts emulsifying homogeneous, control homogenizing speed and temperature, temperature does not exceed 60 ℃.
(6) stop emulsifying after continuing emulsifying stirring 20min, when continuation stirring is cooled to 25 DEG C, stop stirring discharging.
The clinical trial data of embodiment 1:
1.1 study subjects:
By female face skin between 14 to 55 years old for dissimilar 500 ages selecting during 2012 to 2015 Red blood streak patient, wherein, heritability red blood streak 125, stimulated by external environment condition, the sudden high fever that such as produces an unexpected winner, dry environment stimulate skin Produce red blood streak 125, the red blood streak causing using medicine inferior and cosmetics 125, the red blood causing using hormone ointment Silk 125.
1.2 test methods:
After patient per has cleaned skin, it is coated onto skin using this invention product and corresponds to affected part, be softly massaged into skin complete Absorb, skin surface after having massaged, at least will be kept to stop 30min.Continuously use 60 days.
1.3 Outcome measure:
All disappearance person is recovery from illness to red blood streak, and elimination more than 50% person is remarkable result, eliminates more than 30% person for effect effectively, disappears Except less than 30% person is DeGrain.
1.4 result of the tests:
Heritability telangiectasis: recovery from illness 75, account for 60%；Remarkable result 38, accounts for 30.4%；Effective 8, account for 6.4%；Effect Really inconspicuous 5, account for 4%.
External environment condition stimulates red blood streak: recovery from illness 120, accounts for 96%；Remarkable result 5, accounts for 4%.
The telangiectasis that medicine inferior and cosmetics cause: recovery from illness 125, account for 100%.
The red blood streak that hormone ointment causes: recovery from illness 125, account for 100%.
1.5 analysiss of statistical data:
Telangiectasis treatment complexity is followed successively by: heritability, and external environment condition stimulates, and medicine inferior and cosmetics cause, Hormone ointment causes.
1.6 conclusions:
Above-mentioned clinical trial shows, the cream of the present invention has to red blood streak significantly treats and take good care of effect.Although to various Red blood streak effect is unbalanced, but effective percentage can ensure that more than 90%.In this test simultaneously using 60 days be two skin generations of skin Thank the cycle, the persistent period is shorter, if continuing half a year or 1 year it is contemplated that having more preferable effect it is ensured that all types of red blood Silk can be fully recovered.Meanwhile, the present invention select various Chinese medicinal plant compositions, Nantural non-toxic, remove red blood streak while pair Human body skin has good opsonic action, aid in skin health.The skin-nourishing agent added, can provide skin battalion from various angles Support, promote skin epidermis to thicken, recover the skin natural cover for defense, resistance strengthens, fundamentally treat red blood streak.
Above example only have expressed embodiments of the present invention, and its description is more concrete and detailed, but it is not intended that Restriction to invention, as long as the technical scheme being obtained by the way of equivalent or equivalent transformation, all should fall in the present invention Protection domain within.

Claims (8)

1. a kind of have the external medicine composition dispelling skin red blood streak function it is characterised in that described compositionss are by as follows The group of weight is grouped into:
20～30 parts of Flos Carthami, 20～30 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Astragali, 20～30 parts of Ganoderma, 5～10 parts of Pericarpium Citri junoriss, Folium Perillae 1～10 Part, 20～50 parts of Herba Centellae, 0.5～5 part of Rhizoma Smilacis Glabrae, 0.1～10 part of the Rhizoma Atractylodis Macrocephalae, 5～10 parts of Radix et Caulis Opuntiae Dillenii, 1～10 part of Rhizoma Cimicifugae.
2. a kind of preparation method as claimed in claim 1 with the external medicine composition dispelling skin red blood streak function, It is characterized in that, step is as follows:
(1) weight as described in claim 1 weighs crude drug；
(2) crude drug is put in water and decocts water extraction twice, for the first time part by weight 1:15～1 of the crude drug of extraction and water: 40, decocting time is 60～180min, obtains extracting solution, and first time is extracted gained extracting solution and leaches, and filtering residue adds to be filtered relatively The water that 20 ~ 60 times of slag weight is decocted, and decocting time obtains second extracting solution for 60～120min, merges extracting solution twice and obtains To external medicine composition crude extract；
(3) cool down crude extract to 22 ~ 28 DEG C, the filter cloth using 100～200 mesh is filtered, in the filtrate obtaining, as external Drug composition.
3. a kind of have the external-use skin care preparation dispelling skin red blood streak function it is characterised in that described skin care formulation is by right Require the external medicine composition described in 1 and skin care item adjuvant composition.
4. a kind of have the external-use skin care preparation dispelling skin red blood streak function as claimed in claim 3 it is characterised in that institute State skin care formulation to be grouped into by the group of following percentage by weight:
0.01～5% oligopeptide
0.1～2% allantoin
0.01～1% ceramide
1～10% butanediol
1～5% glycerol
0.5～3% lecithin
1～5% emulsifying agent
0.01～1% hyaluronate sodium
5～25% external medicine composition
2～5% safflower oil
2～5% Jojoba oil
It is supplemented to 100% with water.
5. a kind of have the external-use skin care preparation dispelling skin red blood streak function as claimed in claim 4 it is characterised in that institute The oligopeptide stated is oligopeptide -1, oligopeptide -3, oligopeptide -5, at least one in oligopeptide -6.
6. a kind of have the external-use skin care preparation dispelling skin red blood streak function as claimed in claim 4 it is characterised in that institute The ceramide stated is, Cer EOS, Cer NS, ceramide 3, at least one in Cer AP.
7. a kind of have the external-use skin care preparation dispelling skin red blood streak function as claimed in claim 4 it is characterised in that institute The preferred sorbitan stearate of emulsifying agent stated, sorbitan laurate, sucrose cocounut oil acid esters, dicetyl phosphate, Hard Fat Alcohol polyethers 2, stereth 21, at least one in ceteth -10 phosphate ester.
8. a kind of have the external-use skin care preparation dispelling skin red blood streak function as claimed in claim 4 it is characterised in that institute Stating skin care formulation is cream, or emulsion or skin cream.
CN201610952013.8A 2016-11-03 2016-11-03 Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition Pending CN106362053A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610952013.8A CN106362053A (en) 2016-11-03 2016-11-03 Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition
PCT/CN2016/105803 WO2018082117A1 (en) 2016-11-03 2016-11-14 External traditional chinese medicine composition having function of removing red blood in skin and skin care preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610952013.8A CN106362053A (en) 2016-11-03 2016-11-03 Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition

Publications (1)

Publication Number Publication Date
CN106362053A true CN106362053A (en) 2017-02-01

Family

ID=57893466

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610952013.8A Pending CN106362053A (en) 2016-11-03 2016-11-03 Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition

Country Status (2)

Country Link
CN (1) CN106362053A (en)
WO (1) WO2018082117A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107320583A (en) * 2017-07-04 2017-11-07 合肥丰瑞隆生物科技有限公司 Eradicates is except external application Chinese medicine extract of red blood silk and preparation method thereof and external preparation
CN107375713A (en) * 2017-07-04 2017-11-24 合肥丰瑞隆生物科技有限公司 The Chinese medical extract and preparation method and external preparation of red blood silk effect are removed with Eradicates
CN109674890A (en) * 2019-01-17 2019-04-26 青海大学 The composition and skin care item and preparation method of prevention and/or treatment skin red capillary

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102935125A (en) * 2012-11-29 2013-02-20 北京工商大学 Externally applied Chinese herbal composition with facial redness removing effect, preparation and method for preparing externally applied Chinese herbal composition with facial redness removing effect
CN103948817A (en) * 2014-01-15 2014-07-30 北京工商大学 External application traditional Chinese medicine composition with effects of acne and comedo removing and telangiectasis relieving, and skin care preparation and preparation method thereof
CN105055575A (en) * 2015-08-24 2015-11-18 北京太和逸肤科技有限公司 External application traditional Chinese medicine composition and preparation with skin whitening and qi and blood promoting effects and preparation method of external application traditional Chinese medicine composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102000006B (en) * 2010-12-03 2012-05-30 北京工商大学 Skin care composite and preparation with function of eliminating facial redness and preparation methods thereof
CN103735440A (en) * 2013-12-08 2014-04-23 刘聪 Telangiectasis removing face cream
CN105055289B (en) * 2015-07-20 2018-01-02 毛春红 A kind of multifunctional skin-protection, the Chinese medicinal skin care liquid of tender skin and its production method
CN105963178B (en) * 2016-05-15 2018-08-31 广州京妍生物科技有限公司 Has effects that the cosmetic composition of red blood silk

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102935125A (en) * 2012-11-29 2013-02-20 北京工商大学 Externally applied Chinese herbal composition with facial redness removing effect, preparation and method for preparing externally applied Chinese herbal composition with facial redness removing effect
CN103948817A (en) * 2014-01-15 2014-07-30 北京工商大学 External application traditional Chinese medicine composition with effects of acne and comedo removing and telangiectasis relieving, and skin care preparation and preparation method thereof
CN105055575A (en) * 2015-08-24 2015-11-18 北京太和逸肤科技有限公司 External application traditional Chinese medicine composition and preparation with skin whitening and qi and blood promoting effects and preparation method of external application traditional Chinese medicine composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107320583A (en) * 2017-07-04 2017-11-07 合肥丰瑞隆生物科技有限公司 Eradicates is except external application Chinese medicine extract of red blood silk and preparation method thereof and external preparation
CN107375713A (en) * 2017-07-04 2017-11-24 合肥丰瑞隆生物科技有限公司 The Chinese medical extract and preparation method and external preparation of red blood silk effect are removed with Eradicates
CN109674890A (en) * 2019-01-17 2019-04-26 青海大学 The composition and skin care item and preparation method of prevention and/or treatment skin red capillary
CN109674890B (en) * 2019-01-17 2021-08-06 青海大学 Composition and skin care product for preventing and/or treating skin red blood streak and preparation method thereof

Also Published As

Publication number Publication date
WO2018082117A1 (en) 2018-05-11

Similar Documents

Publication Publication Date Title
CN102028752B (en) Chinese herbal medicine compound freckle-removing and skin-whitening composition and external preparation
CN104825351B (en) A kind of Lignum Aquilariae Resinatum whitening cleansing facial milk containing and preparation method thereof
CN106389219A (en) Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation
JP5646117B2 (en) Hair growth promoter and production method
CN105125466A (en) Freckle removing night cream and preparing method thereof
CN109044941B (en) Skin firming, nourishing and moisturizing composition and preparation method and application thereof
CN105342908A (en) Centella asiatica beauty and anti-wrinkle traditional Chinese medicinal ointment for relieving wrinkles and preparation method of traditional Chinese medicinal ointment
CN105496917A (en) Herba centellae anti-wrinkling face cream and preparation method thereof
CN103751466B (en) A kind of Chinese medicine preparation for the treatment of alopecia seborrheica and preparation method thereof
CN104984074A (en) Feature-beautifying skin-care product and production method and application thereof
CN106362053A (en) Externally-applied traditional Chinese medicine composition with function of removing couperose skin and skin-care preparation of composition
CN105616318A (en) Anti-wrinkle and skin-firming herba centellae traditional Chinese medicine facial mask and preparation method therefor
CN108272700A (en) A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies
CN105147577A (en) Toner capable of relieving melanin deposition and preparation method of toner
CN100579556C (en) Preparation method of Chinese medicinal capsule for treating apoplexy
CN112656930A (en) Traditional Chinese medicine shampoo for growing and blackening hair and preparation method thereof
CN102580052B (en) Pilatory and preparation method thereof
CN106667852A (en) Traditional Chinese medicine cream for removing acne and preparation method thereof
CN115006336B (en) Plant shampoo capable of preventing hair loss, strengthening hair, removing dandruff and relieving itching and preparation method thereof
CN106039022A (en) Skin brightening and whitening traditional Chinese medicinal composition, skin brightening and whitening traditional Chinese medicinal preparation, skin brightening and whitening mask and preparation method
CN109908070A (en) Herbaceous plant U.S. face film mud formula
CN111700847B (en) Composition for treating dark eye circles by synergistic laser, eye essence and preparation method
CN107362244A (en) A kind of Eradicates removes the Chinese medical extract and its external preparation of red blood trace on face
CN107375613A (en) A kind of Chinese medical extract and its external preparation that red blood trace on face effect is removed with Eradicates
CN100534501C (en) External use medicine liquid for treating alopecia

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20170201