CN109674890B - Composition and skin care product for preventing and/or treating skin red blood streak and preparation method thereof - Google Patents

Abstract

The invention discloses a composition and a skin care product for preventing and/or treating red blood streaks on skin and a preparation method thereof, wherein the composition comprises 20-50 parts of saussurea medusa Maxim, 15-30 parts of safflower, 18-30 parts of astragalus, 10-20 parts of lycium ruthenicum Murr and 10-18 parts of myrobalan. The skin cream for preventing and/or treating facial red blood streak has high cure rate, can also preserve moisture and beautify the face, and is safe and effective.

Description

Composition and skin care product for preventing and/or treating skin red blood streak and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines and skin care products, in particular to a composition and an external preparation for preventing and/or treating skin red blood streak.

Background

The dilation of facial capillaries is commonly called as "red blood streak", which refers to a facial phenomenon caused by the expansion of capillaries due to the fact that the positions of the capillaries are easy to contact and sense the change of external environment because of the weakness of the stratum corneum of the face.

The face of a patient with facial redness looks redder than normal skin tone. People often call plateau face or red face eggs or rotten apples, some apples only have red cheeks at two sides, and the boundaries are round and generally arranged in a thread shape. For people with thin and sensitive skin, the face is redder when people are too cold, too hot and excited. Severe cases also form a sedimentary stain, which is difficult to cure. Obviously, the appearance of the patient is affected by the red blood streak on the face, and particularly for many female patients who love beauty, the phenomenon is necessarily very interesting, so that the beauty is affected, the psychological pressure of the patient is increased, but the existing medicines or skin care products are difficult to have good curative effect, and the heart and head disease of the patients is caused.

Disclosure of Invention

The invention mainly solves the technical problem of providing a composition and a skin care product for preventing and/or treating red blood vessels on the skin and a preparation method thereof, which can effectively dilate and resolve the facial capillaries of a patient and have low sensitization.

In the field of traditional Chinese medicine, the red blood streak is called red blood surface, and the main reasons are as follows: the treatment method by the traditional Chinese medicine is safer and more effective than western medicines and does not generate dependence.

In order to solve the technical problems, the invention adopts a technical scheme that:

the composition is provided, and raw materials of the composition comprise the following components in parts by weight: 20-50 parts of saussurea medusa Maxim, 15-30 parts of safflower, 18-30 parts of astragalus membranaceus, 10-20 parts of lycium ruthenicum Murr and 10-18 parts of myrobalan.

The preparation method of the composition comprises the following steps:

(1) taking mother snow lotus herb; (2) taking safflower; (3) taking astragalus; (4) taking black wolfberry; (5) taking myrobalan; (6) and (3) extracting with alcohol.

Wherein any one or two or more of (1) to (5) may be combined with (6), that is, the following combinations may be included, but not limited to:

A. respectively and independently taking the (1) to (5) and respectively extracting with alcohol;

B. alcohol extraction is carried out after at least two of (1) - (5) are combined, and the rest of (1) - (5) can be extracted by alcohol alone or after being combined; for example, herba Adonidis and Carthami flos are mixed and extracted with ethanol, and radix astragali, fructus Lycii and fructus Chebulae are extracted with ethanol separately; or mixing radix astragali and fructus Chebulae, extracting with ethanol, mixing herba Saussureae Involueratae, Carthami flos and fructus Lycii, and extracting with ethanol.

Of course, the above preparation method may further include one or more operations of conventional degreasing, mixing, concentrating, and drying, and may be added according to actual needs by referring to conventional methods in the art.

Further, the raw materials of the composition comprise the following components in parts by weight: 18-45 parts of saussurea medusa extract, 13-26.5 parts of safflower extract, 15-26.5 parts of astragalus extract, 8.5-18 parts of lycium ruthenicum extract and 8.5-15.5 parts of myrobalan extract.

The jellyfish snow lotus herb is dry whole herb of jellyfish snow lotus herb of Compositae, is a common traditional Chinese and Tibetan medicine, is sweet and bitter in taste and warm in nature, can promote blood circulation to remove blood stasis, and heals head and facial wounds; modern medical research proves that the snow lotus herb contains effective components such as flavone, alkaloid, polysaccharide and the like, so that the snow lotus herb has the biological functions of resisting inflammation, resisting radiation and eliminating free radicals.

The safflower of the invention is dry flower of safflower of Compositae, which is warm in nature, non-toxic, and can promote blood circulation to remove blood stasis, dredge channels and relieve pain; modern medical research finds that the red wine contains antioxidant components such as flavone and vitamin E, can play a certain role in preventing skin aging, and can also activate blood and dissolve stasis.

The astragalus root is dry root of astragalus root of leguminous plant, is mild in nature, is non-toxic, and has the effects of strengthening the middle-jiao and replenishing qi, and is the long term of tonics; modern medical research proves that the astragalus has higher contents of flavone and polysaccharide components, so that the astragalus has stronger anti-aging and anti-oxidation effects and qi tonifying effects.

The lycium ruthenicum murr is prepared from dried mature fruits of lycium ruthenicum murr of solanaceae, is widely applied in Tibetan medicine, is warm in nature and non-toxic, and can delay senescence, treat cardiovascular diseases and the like; modern researches prove that the lycium ruthenicum contains a large amount of flavone, procyanidine and other components which are the most effective natural free radical scavenger and can delay skin histocyte aging and increase capillary vessel elasticity.

The myrobalan is dry mature fruits of the myrobalan of the Combretaceae, is a traditional Tibetan medicine, is mild in nature, is non-toxic, can astringe to descend qi, astringes lung and astringes intestine; modern medical research proves that flavone and tannic acid components in myrobalan are abundant, and tannic acid can inhibit histamine decarboxylase.

The invention combines the basic theory of traditional Chinese medicine and the modern pharmacological research of western medicine as the guide basis for medicine selection, selects the composition consisting of the medicines to invigorate qi and generate blood, simultaneously selects the medicine safflower for promoting blood circulation and removing blood stasis, fundamentally solves the pathogenesis of the red blood streak, is matched with the saussurea medusa, the lycium ruthenicum and the myrobalan in the composition to play a synergistic effect, can contract and expand capillary vessels, has an obvious repairing effect on the facial red blood streak formed by blood stasis, and effectively improves the facial red blood streak phenomenon of a patient.

Further, the extracts are all alcohol extracts. The alcohol extract includes, but is not limited to, methanol extract, ethanol extract, propanol extract, n-butanol extract.

The invention also provides a preparation method of the composition, which comprises the following steps:

(1) preparing extracts of the raw medicinal materials: pulverizing each raw material respectively, defatting, extracting with ethanol, collecting ethanol extractive solution, concentrating, and drying to obtain extract of each raw material;

(2) mixing the extracts of the raw medicinal materials prepared in the step (1).

In the specific embodiment of the invention, the alcohol extraction adopts ultrasonic extraction, and the cavitation, mechanical effect and thermal effect of ultrasonic waves can be utilized to accelerate the dissolution of effective substances in cells, thereby improving the extraction efficiency.

The invention also provides application of the composition in preparing a product for preventing and/or treating cutaneous red blood streak.

Further, the product is an external preparation. Including but not limited to skin care products, pharmaceuticals, nutraceuticals, etc. for external application to the skin.

The invention also provides a product for preventing and/or treating cutaneous red blood streak, which comprises any composition.

Further, the product is a skin care product or a skin external medicine.

The skin care product or the skin external medicine comprises the composition or the active ingredients in the composition, and auxiliary materials acceptable in the fields of cosmetics and medicine, and of course, the skin care product or the skin external medicine can also comprise effective components with other treatment functions.

The invention also provides a skin care product for preventing and/or treating red blood streaks on skin, which comprises the following raw materials in percentage by weight: 10-15% of any of the above composition, 0.5-1.0% of carbomer, 1.0-2.0% of chamomile hydrosol, 0.01-0.05% of hyaluronic acid, 2.5-3.0% of glycerol, 0.5-1.0% of butanediol, 0.5-1.0% of triethanolamine, 0.01-0.06% of ceramide, 2.0-3.0% of shea butter, 1.5-2.5% of glycerol monostearate, 1.0-2.0% of grape seed oil, 1.0-2.0% of jojoba oil, 0.1-0.5% of squalane, 0.5-1.0% of tea tree essential oil, 0.01-0.05% of rose essential oil and the balance of deionized water.

The invention provides a preparation method of the skin care product, which comprises the following steps:

(1) heating carbomer, chamomile hydrosol, hyaluronic acid, glycerol, butanediol, ceramide, triethanolamine and deionized water to obtain a mixture A;

(2) heating shea butter, glyceryl monostearate, grape seed oil, jojoba oil and squalane to obtain mixture B;

(3) adding the mixture B into the mixture A, homogenizing and emulsifying to obtain an emulsion;

(4) mixing the obtained emulsion with tea tree essential oil, rose essential oil and composition, and homogenizing.

Due to the volatility of the essential oil, the temperature of the emulsion can be properly adjusted when the essential oil is added to avoid the volatilization loss of the essential oil caused by high temperature. For example, in one embodiment of the present invention, the essential oil is added at about 50 ℃, although other temperatures are possible, including but not limited to 40 ℃, 45 ℃ and the like. The temperature is selected as long as the volatilization of the essential oil can be avoided and the uniform mixing is ensured.

The invention has the beneficial effects that:

(1) the composition can contract and expand capillary vessels, contract and expand the capillary vessels, promote blood circulation to remove blood stasis, play an obvious role in repairing facial red blood filaments, has low allergenicity and high safety, and can be used for preparing skin care products or medicines for preventing and/or treating the skin red blood filaments.

(2) The composition has simple and feasible preparation process, and can effectively obtain the composition for treating facial red blood streak used in the subsequent preparation of skin care products or medicines.

(3) The skin cream has the advantages of high cure rate for patients with facial red blood streak, obvious effect, low sensitization and high safety.

Detailed Description

Example 1 preparation of herbal extracts

The preparation of the saussurea medusa extract comprises the following steps:

crushing the medicinal materials, degreasing by adopting diethyl ether, removing fat-soluble impurities, performing ultrasonic extraction for 1h at 50 ℃ by using 50% of methanol, centrifuging and filtering; concentrating the filtrate with rotary evaporator, evaporating the concentrate to dryness, and grinding into powder to obtain jellyfish herba Saussureae Involueratae extract powder with yield of 90%.

Preparing a safflower extract or an astragalus extract:

crushing the medicinal materials, degreasing by adopting diethyl ether, removing fat-soluble impurities, performing ultrasonic extraction for 1h at 75 ℃ by using 75% of methanol, and filtering; concentrating the filtrate with rotary evaporator, evaporating the concentrate to dryness, and grinding into powder to obtain Carthami flos extract powder (yield of 87%) or radix astragali extract powder (yield of 87%).

Preparing a lycium ruthenicum extract:

pulverizing the medicinal materials, defatting with diethyl ether, removing liposoluble impurities, ultrasonic extracting with 60% methanol at 50 deg.C for 25min, and filtering; concentrating the filtrate with rotary evaporator, evaporating the concentrate to dryness, and grinding into powder to obtain Lycium ruthenicum Murr extract powder with yield of 89%.

Preparing a myrobalan extract:

crushing the medicinal materials, degreasing by adopting diethyl ether, removing fat-soluble impurities, performing ultrasonic extraction for 1h at 50 ℃ by using 30% by mass of methanol, and filtering; concentrating the filtrate with rotary evaporator, evaporating the concentrate to dryness, and grinding into powder to obtain fructus Chebulae extract powder with yield of 86%.

The corresponding extracts were prepared by the method of example 1 using the application amounts of the raw materials of each of the groups H to L in Table 1, respectively, and then mixed to obtain the compositions of each group of the present invention.

TABLE 1

	H	I	J	K	L
						Jellyfish snow lotus (g)	25	30	20	36	42
Safflower (g)	22	22	25	19	16
						Radix astragali (g)	22	18	27	20	18
Black matrimony vine (g)	15	18	18	14	10
						Medicine terminalia fruit (g)	16	12	10	11	14

Example 2

The basic formula of the skin cream comprises the following components in percentage by weight:

0.5-1.0% of carbomer, 1.0-2.0% of chamomile hydrosol, 0.01-0.05% of hyaluronic acid, 2.5-3.0% of glycerol, 0.5-1.0% of butanediol, 0.5-1.0% of triethanolamine, 0.01-0.05% of ceramide, 2.0-3.0% of shea butter, 1.5-2.5% of glyceryl monostearate, 1.0-2.0% of grape seed oil, 1.0-2.0% of jojoba oil, 0.1-0.5% of squalane, 0.5-1.0% of tea tree essential oil, 0.01-0.05% of rose essential oil and the balance of 100% of deionized water.

Carrying out moisture retention detection on the skin care basic cream of the basic formula with different proportions, and selecting the basic formula with the optimal proportion:

the skin hydration is tested by adopting SKICON 200 type skin stratum corneum water content tester, the testing principle is that the stratum corneum contains a large amount of electrolyte, the electrolyte in the existing water has conductivity, the phenomenon is also generated on the skin surface, and the change of the conductivity reflects the hydration state of the skin after the test probe is contacted with the skin.

The subject is a healthy female without skin diseases, and the experimental conditions are that the temperature and the humidity of the environment are required to be constant during the test period, the temperature is 20 +/-2 ℃, and the relative humidity is 30-60%. The test samples were: (1) the first to the fifth groups of skin care basic cream without the composition; (2) 10% glycerin skin cream served as standard reference. The results are shown in Table 2.

Wherein, the proportions of the components in the basic skin cream are shown in the following table 2:

TABLE 2

The preparation method of the skin-care foundation cream comprises the following steps: mixing the raw materials in the phase A, heating to 75 ℃, and keeping the temperature for 15 minutes; mixing the raw materials in the phase B, heating to 85 ℃, and keeping the temperature for 25 minutes. Slowly adding the raw material of the phase B into the phase A, and homogenizing and emulsifying for 20 minutes. Cooling to 50 deg.C, sequentially adding C, D phase raw materials, and homogenizing for 15 min to obtain skin care base cream.

The method for testing the moisture retention performance comprises the following steps: (1) the left and right forearm test areas were determined, the areas being 5cm x 5cm, and the blank values of the areas were tested separately. (2) Applying 10% glycerin skin cream on one area as reference sample, applying the skin cream of the present invention on the other area as test sample, and using amount of 2mg/cm². (3) And testing 30min, 60min and 120min after use, testing 3-4 points, respectively recording the electric conductivity of the electric conductors to average, and obtaining the results shown in table 3.

TABLE 3 comparison of skin conductivity using Glycerol skin cream or the first to the fifth group of skin base creams

From the above experimental results it can be seen that: the conductivity change of the group I-II skin-care base cream is approximate to that of the 10% glycerin skin-care cream, so that the base cream has better moisturizing performance, wherein the moisturizing performance of the group II is the best, and the base cream is determined to be the optimal proportioning base formula of the skin-care base cream.

The skin cream of the invention was prepared by using the optimal basic formula, as shown in table 4, of which composition K:

TABLE 4

The preparation method of the skin cream comprises the following steps: mixing the raw materials in the phase A, heating to 75 ℃, and keeping the temperature for 15 minutes; mixing the raw materials in the phase B, heating to 85 ℃, and keeping the temperature for 25 minutes. Slowly adding the raw material of the phase B into the phase A, and homogenizing and emulsifying for 20 minutes. And (3) sequentially adding C, D, E phase raw materials when the temperature is cooled to 50 ℃, and continuing homogenizing for 15 minutes to obtain the skin cream.

The moisture retention of the skin cream of the sixth to the eighth groups was measured by the same method as above, and the results are shown in table 5.

TABLE 5 variation of skin conductivity using the skin cream of the sixth to the eighth groups of the present invention

Time	⑥(uv)	⑦(uv)	⑧(uv)
				0min	358	355	358
30min	118	121	120
				60min	86	88	89
120min	54	55	55

The experimental results show that after the composition is added, the moisturizing performance of the skin cream is better than that of a skin base cream without the composition, and the composition plays a synergistic effect with other components of the skin cream, so that the moisturizing performance of the skin cream is enhanced. From the data, the change of the dosage of the composition has little influence on the moisturizing performance of the skin cream, and finally, the component proportion of the skin cream in the eighth group is selected to be the optimal proportion of the skin cream.

The following test examples demonstrate the therapeutic effect and safety of the composition and skin cream of the present invention on erythromycins.

Test example 1 Experimental study on skin sensitization

The sensitization of the skin cream for treating facial redness of the invention to the skin of guinea pigs is observed through animal experiments. The skin cream used in this test was the skin cream containing the composition of group K prepared by the preparation method of example 2 of the present invention (the ratio is the optimal ratio of the skin cream of group viii).

50 common-grade guinea pigs are selected, the weight of the guinea pigs is controlled to be 180-250 g, the room temperature is controlled to be 20-22 ℃, the humidity is 40-67%, and the guinea pigs are illuminated for 12h/12h with alternating light and shade day and night during the test period. Dyeing guinea pigs according to the number, and marking the ones by using saturated picric acid (yellow) solution and marking the tens by using 2% silver nitrate solution (coffee); the guinea pigs are separately bred according to the sex, five guinea pigs are placed in each cage box, labels are attached to the outside of the cage boxes, and information such as animal types, sex, administration routes, animal numbers, experiment dates and the like is marked.

According to the national drug registration management method and the technical guidance principle of research on irritation, allergy and hemolysis of chemical drugs. Randomly dividing into blank matrix group, positive control group and medicinal composition group. The blank matrix group contained 10 guinea pigs, and the remaining two groups contained 20 guinea pigs each, each guinea pig group being hermaphroditic. The induced sensitization and stimulated contact tests were performed sequentially, with 10 days of washout between the two tests. The induction contact test method was performed by first 24h skin preparation, minus the hair coat in the 2cm x 2cm area on each side of the guinea pig spine.

Positive control group: taking 0.2g of 2.5 percent acetone solution of 2, 4-dinitrochlorobenzene, respectively covering the solution by two layers of gauzes (2.5cm multiplied by 2.5cm) and a layer of preservative film, covering the solution by non-irritant gauzes for 6 hours, removing the covering, removing residual test samples by warm water, and repeating the same method once on the 7 th day and the 14 th day. The same parts of the blank substrate group animals are coated with 0.1g of blank substrate (physiological saline), the test group is coated with 0.1g of the skin cream, and the induction test is carried out according to the same steps.

The contact stimulation is carried out by applying 0.1g of the skin cream of the invention to the back skin of guinea pigs in the test group 14 days after the last sensitization contact with the test substance (i.e. 28 days of the experiment), packing and fixing, removing the test substance after 6h, immediately observing, and observing the skin allergy again at 24h, 48h and 72 h. The positive control group is coated with 0.1g of blank substrate at the same part of animal with 0.2g of 2.5% acetone solution of 2, 4-dinitrochlorobenzene, and erythema, edema and other abnormal reactions of the skin after administration are observed at 1h and 24h after sensitization and at 24h, 48h and 72h after excitation. And scoring the skin erythema and edema according to the skin anaphylaxis scoring standard, calculating the anaphylaxis incidence rate of each group, and judging the anaphylaxis incidence degree according to the skin anaphylaxis scoring standard. The incidence of anaphylaxis (number of animals in the group with cutaneous erythema, edema, or generalized anaphylaxis/total number of animals in the group) × 100%.

Judging whether skin allergic reaction occurs or not according to the research technical guide principle of the irritation, the anaphylaxis and the hemolysis of the chemical drugs 24h, 48h and 72h after the contact test is stimulated, judging that the skin allergic reaction of the animal is positive when the allergic reaction score is more than or equal to 2 min, calculating the sensitization rate (the number of animals more than or equal to 2/the number of animals in the group multiplied by 100%), and judging the sensitization strength of the composition on the skin of the guinea pig according to the experimental grading standard of the skin allergic reaction in the research technical guide principle of the irritation, the anaphylaxis and the hemolysis of the chemical drugs. The skin sensitization degree score criteria are shown in Table 4, the skin sensitization degree score criteria are shown in Table 5, and the test results are shown in Table 6.

TABLE 4 skin sensitization score criteria

TABLE 5 grading Standard of skin sensitization degrees

TABLE 6 pharmaceutical composition Guinea pig skin allergy evaluation

From the above results, it was found that erythema appeared on the skin of the excitation site of guinea pigs in the positive control group at 6 hours after the excitation, the incidence of allergic reaction was 100%, and the allergic reaction was evaluated as very strong sensitization. After 48 hours of excitation, the skin of the excitation part of the positive control guinea pig still has erythema, the incidence rate of anaphylactic reaction is 100 percent, and the anaphylactic reaction evaluation is still extremely strong.

For the blank matrix group and the test group, after the skin is excited for 24 hours, 48 hours and 72 hours, the skin of the excitation part of the guinea pig of the blank matrix group and the test group has no erythema and edema, and has no other abnormal reaction, the incidence rate of anaphylactic reaction is 0, and the anaphylactic reaction evaluation has no skin anaphylactic reaction.

The tests show that the skin cream containing the composition has low sensitization and high safety, and can be popularized and used.

Test example 2 skin cream effect test

In the following experiments, the skin cream for treatment was the skin cream prepared from the composition of groups H to L prepared in example 1 according to the optimal formulation and method of the group viii of example 2.

300 cases of patients with facial redness are selected, all of which are female, the age is 22-41 years, the average age is 35 years, and the course of disease is 1-15 years. The skin damage is mainly on the cheeks, cheeks and on both sides of the nose, and is not caused by primary telangiectasia. Among them, 82 cases of cosmetics were used improperly, 75 cases of beauty care were used improperly, 58 cases of skin drugs were used externally, 85 cases of people were used due to sunshine, but no significant skin atrophy was observed, and the treatment was not performed by laser, living cell therapy, etc., and the treatment was randomly divided into 6 groups (5 groups in the treatment group, 1 group in the control group), and there was no significant difference in sex, age, and disease condition among the 6 groups.

Treatment groups: after the skin cream is used, the skin cream is applied to the vasodilatation part of the facial sweater after the face is cleaned, and the time is 3 times per day. Control group: the fourth group of skin-care foundation cream is smeared on the dilated capillary vessels of the face for 3 times per day according to the method. The treatment effect was observed after 60 days of treatment and evaluated. The results are shown in Table 7, wherein the group H indicates that the skin cream used by the patients in this group contains the composition of group H of example 1, and I, J, K, L has the same effect.

The observation index and the scoring standard of the curative effect are as follows: objective signs: the criteria for improvement of facial capillaries are classified into 4 grades: and (3) healing: the capillary vessel dilation is resolved to 90% -100%; the effect is shown: the capillary vessel dilation is resolved to 70% -89%; the method has the following advantages: the telangiectasia subsides by 30% -69%; and (4) invalidation: the telangiectasia resolved below 30% or there was no significant change.

TABLE 7 Objective signs improvement of patients

The test results show that the skin-care base cream in the fourth group, which does not contain the composition, has low improvement efficiency on the red blood streak, and the skin-care cream can effectively improve the clinical symptoms of patients with facial red blood streak, can dilate and regress the capillary vessels on the face of the patients, and has remarkable treatment effect on the facial red blood streak, wherein the skin-care cream containing the composition in the K group has the most remarkable treatment effect, and is suitable for being popularized to prepare the skin-care cream for preventing and/or treating the facial red blood streak by using the components in the formula.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (8)

1. The composition for preventing and/or treating cutaneous red blood streak is characterized by being prepared from the following raw materials in parts by weight: 20-50 parts of saussurea medusa Maxim, 15-30 parts of safflower, 18-30 parts of astragalus membranaceus, 10-20 parts of lycium ruthenicum Murr and 10-18 parts of myrobalan;

the preparation method of the composition comprises the following steps:

(1) taking mother snow lotus herb; (2) taking safflower; (3) taking astragalus; (4) taking black wolfberry; (5) taking myrobalan; (6) and (3) extracting with alcohol.

2. The composition for preventing and/or treating cutaneous red blood streak is characterized by being prepared from the following raw materials in parts by weight: 18-45 parts of saussurea medusa extract, 13-26.5 parts of safflower extract, 15-26.5 parts of astragalus extract, 8.5-18 parts of lycium ruthenicum extract and 8.5-15.5 parts of myrobalan extract; the extracts are all alcohol extracts.

3. A method of preparing the composition of claim 2, comprising the steps of:

(1) preparing extracts of the raw medicinal materials: pulverizing each raw material respectively, defatting, extracting with ethanol, collecting ethanol extractive solution, concentrating, and drying to obtain extract of each raw material;

(2) mixing the extracts of the raw medicinal materials prepared in the step (1).

4. Use of the composition according to any one of claims 1 and 2 for the preparation of a product for the prevention and/or treatment of cutaneous erythromyces; the product is an external preparation.

5. A product for preventing and/or treating cutaneous erythromyces, comprising a composition according to any one of claims 1 and 2.

6. The product of claim 5, wherein the product is a skin care product or a skin external medicine.

7. The skin care product for preventing and/or treating the skin red blood streak is characterized by being prepared from the following raw materials in percentage by weight: 10-15% of the composition of any one of claims 1 and 2, 0.5-1.0% of carbomer, 1.0-2.0% of chamomile pure water, 0.01-0.05% of hyaluronic acid, 2.5-3.0% of glycerol, 0.5-1.0% of butanediol, 0.5-1.0% of triethanolamine, 0.01-0.06% of ceramide, 2.0-3.0% of shea butter, 1.5-2.5% of glycerol monostearate, 1.0-2.0% of grape seed oil, 1.0-2.0% of jojoba oil, 0.1-0.5% of squalane, 0.5-1.0% of tea tree essential oil, 0.01-0.05% of rose essential oil and the balance of deionized water.

8. A method of making a skin care product according to claim 7 comprising the steps of:

(1) heating carbomer, chamomile hydrosol, hyaluronic acid, glycerol, butanediol, ceramide, triethanolamine and deionized water to obtain a mixture A;

(2) heating shea butter, glyceryl monostearate, grape seed oil, jojoba oil and squalane to obtain mixture B;

(3) adding the mixture B into the mixture A, homogenizing and emulsifying to obtain an emulsion;

(4) mixing the obtained emulsion with tea tree essential oil, rose essential oil and the composition of claim 1 or 2, and homogenizing.