CN106943316A - Emulsion of skin regeneration and preparation method thereof can be promoted - Google Patents
Emulsion of skin regeneration and preparation method thereof can be promoted Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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Abstract
The invention belongs to technique in skin care field, and in particular to a kind of to promote emulsion of skin regeneration and preparation method thereof.The present invention can promote skin regeneration emulsion include following components and its parts by weight：36 parts of Sweet Almond Oil, 0.3 0.6 parts of the benzene in Chinese mugwort ground, 12 parts of vitamin E, 23 parts of fibroin albumen, 1 1.5 parts of skin regeneration promoter, 0.4 0.8 parts of skin penetration enhancer is repeatedly fragrant sour 0.2 0.4 parts, 25 28 parts of 0.7 1.2 parts of sodium carboxymethylcellulose, 35 parts of L pyrrolidone sodium carboxylates and deionized water.The present invention can promote the preparation method of the emulsion of skin regeneration to include：Oil phase is made in Chinese mugwort ground benzene and vitamin E etc.；Aqueous phase is made in fibroin albumen and the fragrant acid etc. that changes；Oil phase is added in aqueous phase, emulsifying, deaeration.The present invention can promote the emulsion of skin regeneration without skin irritatin, without allergic, safe, can realize the reparative regeneration of skin.
Description
Technical field
The invention belongs to technique in skin care field, and in particular to a kind of emulsion for promoting skin regeneration and its preparation side
Method.
Background technology
Skin, as the age is continuously increased, all gradually tends to aging as other organs.The aging of skin be it is a kind of just
Chang Xianxiang, since being born we, the phenomenon of skin aging just exists always, the result of skin aging, the life except making skin
Manage outside hypofunction, it is most important that changed the appearance of people.People are external often through some of skin and hair
Feature, to judge age, identity and the status of a people.Aging makes the beauty of human body lose lustre, therefore, and the appearance of aging can be to the heart of people
Reason produces negative effect, and everybody is intended to keep appearance youth, perpetual youth.Prevention and delay skin aging are Skin cosmesis
Important topic.More influenceed compared with other organs by exogenous stimulus, therefore the aging of skin is endogenous
Factor and the common exercising result of exogenous stimulation factor.The reparation of skin histology is the master to anti aging effect and injury repair
Want process.
Chinese patent application CN106389293A discloses a kind of Dendrobidium huoshanness and promotes skin regeneration combination Essence, by with
The raw material of lower parts by weight is prepared from：15-25 parts of Dendrobidium huoshanness extract, 10-20 parts of spiral snail juice, angle soft-shelled turtle alkene 3-6
Part, 5-10 parts of Gotu Kola P.E, 3-5 parts of extractive of usnea, 3-6 parts of water lotus flower fermentate, 10-15 parts of placental hormone, fresh fish ovum
3-7 parts of nest skin, 5-10 parts of Sheep's-parsley seed extract, 2-3 parts of grape seed extract, 0.05-0.1 parts of hyaluronic acid, water soluble shells are gathered
Sugared 1.5-2.5 parts, 30-40 parts of deionized water, 5-10 parts of ginseng, 5-10 parts of the Radix Astragali.
Chinese patent application CN105963239A discloses a kind of emulsion for promoting skin regeneration, including NMF
0.02-0.2 parts；2-8 parts of bleeding agent；0.06-0.1 parts of preservative；1-3 parts of emulsifying agent；And active component, wherein active component
Including：0.01-10 parts of stem cell composite factor；0.005-0.1 parts of cytolipin plastid；0.01-0.03 parts of allantoin.
At present, the product category for promoting skin regeneration of in the market is various, still, and most of product is mainly by thin
Born of the same parents' nutritional ingredient, so that needed for filling because of aging the extracellular matrix of defect and providing cell metabolism consumption, it is impossible to from true
The reparative regeneration of skin is realized in positive meaning.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of emulsion and its system for promoting skin regeneration
Preparation Method.The emulsion property of what the present invention was provided promote skin regeneration is gentle, no skin irritatin, without allergic, security
Height, can realize the reparative regeneration of skin.What the present invention was provided promotes the emulsion preparation method of skin regeneration simple, it is easy to real
Apply.
The technical scheme is that：
A kind of emulsion for promoting skin regeneration, including following components and its parts by weight：
3-6 parts of Sweet Almond Oil, 0.3-0.6 parts of the benzene in Chinese mugwort ground, 1-2 parts of vitamin E, 2-3 parts of fibroin albumen, skin regeneration promotees
Enter 1-1.5 parts of agent, 0.4-0.8 parts of skin penetration enhancer, repeatedly fragrant 0.2-0.4 parts of acid, sodium carboxymethylcellulose 0.7-1.2
Part, 25-28 parts of 3-5 parts of PCA sodium and deionized water.
Further, the emulsion for promoting skin regeneration includes following components and its parts by weight：
5 parts of Sweet Almond Oil, 0.4 part of the benzene in Chinese mugwort ground, 1.5 parts of vitamin E, 2.4 parts of fibroin albumen, skin regeneration promoter 1.3
Part, 0.6 part of skin penetration enhancer is repeatedly fragrant sour 0.3 part, 0.9 part of sodium carboxymethylcellulose, 4 parts of PCA sodium
With 27 parts of deionized water.
Further, the skin regeneration promoter is pressed by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin
Weight is than 7-9: 4-6: 1-3 composition.
Further, the skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin
By weight 8: 5: 2 compositions.
Further, the skin penetration enhancer is by tetrahydrochysene pipering and Laurocapram 4-6: 1-3 group by weight
Into.
Further, the skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 5: 2.
In addition, present invention also offers the preparation method for the emulsion that can promote skin regeneration, step is as follows：
S1 mixes Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E, skin penetration enhancer, stirs, obtains oil phase；
S2 is by fibroin albumen, change fragrant acid, sodium carboxymethylcellulose, skin regeneration promoter and PCA sodium
It is well mixed, it is added in deionized water, stirs to being completely dissolved, obtain aqueous phase；
Oil phase obtained by step S1 is added in aqueous phase obtained by step S2 by S3, carries out emulsifying, mixing speed is 1700-
1800r/min, the emulsifying time is 14-20 minutes, and vacuum defoamation is produced.
Further, the step S3 mixing speeds are 1750r/min.
Further, the step S3 emulsifying times are 18 minutes.
The effect of primary raw material of the present invention：
Vitamin E：No. CAS：1406-66-2, vitamin E is a kind of liposoluble vitamin, and its hydrolysate is tocopherol,
It is one of topmost antioxidant.Vitamin E has the effect of anti-aging, the pigment when can reduce tissue aging in cell
Grain, can also improve skin elasticity, anti-aging.
Fibroin albumen：No. CAS：96690-41-4.Fibroin albumen is a kind of natural polymer protein for coming from silk, its
Content accounts for the 70%~80% of silk, containing 18 kinds of amino acid, and 11 kinds therein are essential amino acid；On the other hand, silk
Fibroin effect harmless to the human body, it is safe and reliable, with good biocompatibility.Fibroin albumen contain 18 kinds of amino acid and
Various trace elements, have stronger affinity, it is easy to absorbed by human skin with human body skin.
It is repeatedly fragrant sour：It is mainly derived from labiate rosemary.No. CAS：80225-53-2, molecular formula：C18H16O8, point
Son amount：360.33.Repeatedly fragrant acid has anti-oxidant, anti-aging；The effects such as strong Weight-reducing and lipid-lowering, for food processing preservative.
Repeatedly fragrant acid has very strong inoxidizability, and its anti-oxidant vigor is better than vitamin E.Repeatedly fragrant acid helps to prevent that free radical from causing
Cell damage, therefore reduce the risk of cancer and artery sclerosis.Also it is used for food antiseptic.
Sodium carboxymethylcellulose：No. CAS：9004-32-4, molecular formula：C8H16NaO8, molecular weight：265.204.Carboxymethyl
Sodium cellulosate is white fibrous or particulate powder.Odorless, it is tasteless, it is tasteless, there is hygroscopicity, insoluble in organic solvent.
PCA sodium：No. CAS：28874513.L- pyrrolidones carboxylic sodium be in keratoderma it is main into
Point, PCA sodium has stronger moisture retention, and the product is the slightly sweetish liquid of clear, colorless odorless.L- pyrroles
Alkanone carboxylic acid sodium is water-soluble.
What the present invention was provided promotes the emulsion of skin regeneration to be promoted by Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E and skin regeneration
Enter the raw materials such as agent to be prepared from.In the present invention, the soft skin of Sweet Almond Oil energy, crease-resistant, whitening, healing scar, with the present invention
In other compositions, such as vitamin E, skin regeneration promoter act synergistically, skin regeneration can be obviously promoted.In the present invention
In, Chinese mugwort ground benzene has anti-oxidation efficacy, is acted synergistically with the other compositions in the present invention, can have obtained product good
Anti-aging, repair skin and protect skin effect.In the present invention, fibroin albumen can provide structure branch for Skin Cell
Hold, the other compositions collective effect with the present invention makes skin plentiful and high resilience, and Skin Cell can be promoted to generate, promote
Skin tissue regeneration.In the present invention, repeatedly fragrant acid being capable of antiseptic and inhibiting bacteria function, anti-oxidant, it is possible to increase the shelf-life of product.At this
In invention, sodium carboxymethylcellulose is mainly used as emulsifying agent, thickener and stabilizer.In the present invention, PCA
Sodium can improve the moisture retention of product.
Found through experiment, the emulsion for promoting skin regeneration that the present invention is provided can promote skin regeneration, nonirritant, nothing
Sensitization, it is safe and reliable.Promote the to be wound experiment of skin regeneration of emulsion through that can promote skin regeneration is found, the 9th after wound
My god, the embodiment 1-3 groups surface of a wound has been substantially that granulation tissue is filled, and edge of wound has been shown in newborn epithelium centrality growth, and contrasts
1 group of example and the rarely seen thin layer granulation of 2 groups of surface of a wound of comparative example, have no obvious newborn epithelium.14 days after wound, 1 group of embodiment, embodiment
2 groups, 3 groups of embodiment, the surface of a wound area of 2 groups of 1 group of comparative example and comparative example be respectively 0.08cm2、0.07cm2、0.06cm2、
0.32cm2And 0.27cm2, this illustrates that the emulsion for promoting skin regeneration prepared by the present invention can promote skin regeneration, shortens the surface of a wound
Healing time.Meanwhile, this explanation the present invention provide by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by certain
Weight than composition skin regeneration promoter, and by tetrahydrochysene pipering and Laurocapram by certain weight ratio constitute it is transdermal
Sorbefacient, mutually collaboration play a part of to promote skin regeneration.
The emulsion of what the present invention was provided promote skin regeneration can provide the nutrition of abundance for dermal matrix cell, significantly
Accelerate the reconstructed velocity of new skin histology, skin is repaired from inside to outside, both prevented infection, the possibility of ulcer, neoplastic skin is made again
Moist smooth, scar of dispelling skin makeup, realizes the reparative regeneration of skin.
Compared with prior art, the emulsion for promoting skin regeneration that the present invention is provided has the advantage that：
(1) emulsion for promoting skin regeneration that provides of the present invention is safe, and property is gentle, no skin irritatin, without skin
Skin allergy.
(2) the emulsion of the invention that promote skin regeneration provided can provide the nutrition of abundance for dermal matrix cell,
The reconstructed velocity of new skin histology is greatly speeded up, skin is repaired from inside to outside, has both prevented infection, the possibility of ulcer, new life is made again
Skin is moistened smooth, scar of dispelling skin makeup, realizes the reparative regeneration of skin.
(3) emulsion preparation method for promoting skin regeneration that the present invention is provided is simple, it is easy to implement.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
Sweet Almond Oil of the present invention is purchased from Zouping Qing Songfang bio tech ltd, article No. 6933723581805；Alkalescence
Fibroblast growth factor is purchased from Beijing Ke Xin bio tech ltd, and biological activity is 2.0 × 107IU/mg；Shell
Oligosaccharides is purchased from Huizhou long queue Bioisystech Co., Ltd, pharmaceutical grade；Barbaloin is purchased from Shanghai and holds the wound limited public affairs of biotechnology
Department, article No. RCZ1027；Chinese mugwort ground benzene is purchased from Guangzhou Xi Ya bio tech ltd, model XY150831.
Embodiment 1, a kind of emulsion for promoting skin regeneration
The emulsion for promoting skin regeneration includes following components and its parts by weight (every part is 400g)：
3 parts of Sweet Almond Oil, 0.3 part of the benzene in Chinese mugwort ground, 1 part of vitamin E, 2 parts of fibroin albumen, 1 part of skin regeneration promoter, thoroughly
0.4 part of skin sorbefacient, repeatedly fragrant 0.2 part of acid, 0.7 part of sodium carboxymethylcellulose, 3 parts of PCA sodium and go from
Sub- 25 parts of water；The skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight 7: 6
: 3 compositions；The skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 4: 3.
Preparation method：
S1 mixes Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E, skin penetration enhancer, stirs, obtains oil phase；
S2 is by fibroin albumen, change fragrant acid, sodium carboxymethylcellulose, skin regeneration promoter and PCA sodium
It is well mixed, it is added in deionized water, stirs to being completely dissolved, obtain aqueous phase；
Oil phase obtained by step S1 is added in aqueous phase obtained by step S2 by S3, carries out emulsifying, and mixing speed is
1700r/min, the emulsifying time is 14 minutes, and vacuum defoamation is produced.
Embodiment 2, a kind of emulsion for promoting skin regeneration
The emulsion for promoting skin regeneration includes following components and its parts by weight (every part is 400g)：
6 parts of Sweet Almond Oil, 0.6 part of the benzene in Chinese mugwort ground, 2 parts of vitamin E, 3 parts of fibroin albumen, 1.5 parts of skin regeneration promoter,
0.8 part of skin penetration enhancer, repeatedly fragrant 0.4 part of acid, 1.2 parts of sodium carboxymethylcellulose and is gone 5 parts of PCA sodium
28 parts of ionized water；The skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight 9
: 4: 1 compositions；The skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 6: 1.
Preparation method：
S1 mixes Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E, skin penetration enhancer, stirs, obtains oil phase；
S2 is by fibroin albumen, change fragrant acid, sodium carboxymethylcellulose, skin regeneration promoter and PCA sodium
It is well mixed, it is added in deionized water, stirs to being completely dissolved, obtain aqueous phase；
Oil phase obtained by step S1 is added in aqueous phase obtained by step S2 by S3, carries out emulsifying, and mixing speed is
1800r/min, the emulsifying time is 20 minutes, and vacuum defoamation is produced.
Embodiment 3, a kind of emulsion for promoting skin regeneration
The emulsion for promoting skin regeneration includes following components and its parts by weight (every part is 400g)：
5 parts of Sweet Almond Oil, 0.4 part of the benzene in Chinese mugwort ground, 1.5 parts of vitamin E, 2.4 parts of fibroin albumen, skin regeneration promoter 1.3
Part, 0.6 part of skin penetration enhancer is repeatedly fragrant sour 0.3 part, 0.9 part of sodium carboxymethylcellulose, 4 parts of PCA sodium
With 27 parts of deionized water；The skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight
Amount is than 8: 5: 2 compositions；The skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 5: 2.
Preparation method：
S1 mixes Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E, skin penetration enhancer, stirs, obtains oil phase；
S2 is by fibroin albumen, change fragrant acid, sodium carboxymethylcellulose, skin regeneration promoter and PCA sodium
It is well mixed, it is added in deionized water, stirs to being completely dissolved, obtain aqueous phase；
Oil phase obtained by step S1 is added in aqueous phase obtained by step S2 by S3, carries out emulsifying, and mixing speed is
1750r/min, the emulsifying time is 18 minutes, and vacuum defoamation is produced.
Comparative example 1, a kind of emulsion for promoting skin regeneration
The emulsion for promoting skin regeneration includes following components and its parts by weight (every part is 400g)：
5 parts of Sweet Almond Oil, 0.4 part of the benzene in Chinese mugwort ground, 1.5 parts of vitamin E, 2.4 parts of fibroin albumen, skin regeneration promoter 1.3
Part, 0.6 part of skin penetration enhancer is repeatedly fragrant sour 0.3 part, 0.9 part of sodium carboxymethylcellulose, 4 parts of PCA sodium
With 27 parts of deionized water；The skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight
Amount is than 1: 1: 1 composition；The skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 5: 2.
Preparation method is similar to Example 3.
Difference with embodiment 3 is that the skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor
With barbaloin by weight 1: 1: 1 composition.
Comparative example 2, a kind of emulsion for promoting skin regeneration
The emulsion for promoting skin regeneration includes following components and its parts by weight (every part is 400g)：
5 parts of Sweet Almond Oil, 0.4 part of the benzene in Chinese mugwort ground, 1.5 parts of vitamin E, 2.4 parts of fibroin albumen, skin regeneration promoter 1.3
Part, 0.6 part of skin penetration enhancer is repeatedly fragrant sour 0.3 part, 0.9 part of sodium carboxymethylcellulose, 4 parts of PCA sodium
With 27 parts of deionized water；The skin regeneration promoter is by chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight
Amount is than 8: 5: 2 compositions；The skin penetration enhancer is made up of tetrahydrochysene pipering and Laurocapram by weight 1: 1.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, the skin penetration enhancer by tetrahydrochysene pipering and Laurocapram by weight
Than 1: 1 composition.
Test example one, the emulsion of skin regeneration can be promoted to promote the experiment of skin regeneration of being wound
1st, test material：Prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 promotes skin again
Raw emulsion.
2nd, subjects：60 female Wistar rats are chosen, body weight is 250g.
3rd, test method：
60 rats are randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and
2 groups of comparative example, every group 12.
Experiment injects 0.25mL/ compound anesthetic (thiophene amine ketone) when starting from abdominal cavity, animal is entered light anaesthesia state,
Then the hair of back 4cm × 5cm areas is cut off.After being sterilized after cropping area, respectively cut both sides in the middle part of the backbone of mouse back with scalpel
A circular surface of a wound is cut, diameter 1.6cm is deep to subcutaneously, cause two circular knife wound surface of a wound.
The emulsion of skin regeneration can be promoted by extracting 0.2mL, be added on the rat surface of a wound, wrapped up after 5 minutes with sterile gauze, be spaced
Dressing on the 1st once, extremely arrives after wound the 14th day.Surface of a wound size is measured during Postoperative Dressing and wound healing situation is recorded.
4th, result of the test：
Result of the test is as shown in table 1.
Table 1：Different time surface of a wound Area comparison (cm after wound2)
As can be seen from Table 1, extension over time, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example
It is gradually reduced with 2 groups of surface of a wound area of comparative example.But, the diminution degree of the surface of a wound area of 2 groups of 1 group of comparative example and comparative example
It is significantly less than embodiment 1-3 groups.It has been observed that the 4th day after wound, the existing granulation tissue growth of embodiment 1-3 groups is local to have grown
Thin layer or point bulk epithelium, edge of wound skin contraction are obvious；The 9th day after wound, the surface of a wound has been substantially that granulation tissue is filled, edge of wound
See that newborn epithelium centrality grows, and 1 group of comparative example and the rarely seen thin layer granulation of 2 groups of surface of a wound of comparative example, have no obvious new life
Epithelium.This explanation, the emulsion produced by the present invention for promoting skin regeneration can promote skin regeneration.
Test example two, can promote skin regeneration emulsion skin irritation test
1st, test material：Prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 promotes skin again
Raw emulsion.
2nd, subjects：60 new zealand rabbits are chosen, male and female half and half, body weight is 2.5kg.
3rd, test method：
60 new zealand rabbits are randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, comparative example 1
Group and 2 groups of comparative example, every group 12, male and female half and half.
24h before experiment, new zealand rabbit back backbone side is lost hair or feathers, 3cm × 3cm on the right side of unhairing scope.To given the test agent
Before go through whether skin of unhairing is damaged because of unhairing, the skin for having damage should not be tested.
Tested new zealand rabbit is fixed in rabbit fixed bin, right side plucked skin is applied to 0.5g test materials
On, application area is (2.5 × 2.5) cm2, smear once daily, continuously smear 14d., should before smearing every time since the 2nd day
Cropping, result is observed after removing residual given the test agent, 1h with warm water.Carry out skin wound repair scoring.The smearing time is 23h,
After smearing, tested new zealand rabbit is put back into rabbit rearging cage and raised.Observation smearing position, which whether there is erythema, oedema, to be formed, and by the institute of table 2
Show that skin wound repair standards of grading are scored, skin irritatin strength grading is as shown in table 3.
4th, result of the test
Result of the test is as shown in table 4.
Table 2：Skin wound repair standards of grading
Table 3：Skin irritatin strength grading
| Skin irritation index | Stimulus intensity rank |
| 0~0.49 | It is nonirritant |
| 0.5~1.99 | Slight stimulation |
| 2.0~5.99 | Moderate excitant |
| 6.0~8.0 | Severe excitant |
Table 4：The emulsion of skin regeneration can be promoted to new zealand rabbit multiple skin irritation reaction integration (dividing)
As can be seen from Table 4,1 group of the embodiment of the present invention, 2 groups of embodiment, daily every animal of 3 groups of embodiment integrate equal
Value (stimulus index) is 0, this explanation, the embodiment of the present invention 1, embodiment 2, can promote skin regeneration made from embodiment 3
Emulsion is nonirritant.And daily every animal integral mean value (stimulus index) of 2 groups of 1 group of comparative example and comparative example is respectively
0.67th, 0.68, this illustrates, the emulsion of skin regeneration can be promoted to have low excitant made from comparative example 1 and comparative example 2.
Test example three, can promote skin regeneration emulsion skin anaphylactic test
1st, test material：Prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2 promotes skin again
Raw emulsion.
2nd, subjects：50 healthy guinea pigs are chosen, body weight is 250g.
3rd, test method：
50 cavys are randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and
2 groups of comparative example, every group 10.
24h before experiment, on the left of guinea pig back or right side is lost hair or feathers, is cleaned up with clear water, does not damage epidermis, unhairing scope
Equal 3cm × the 3cm of left and right side.
Sensitization contact：With the emulsion of skin regeneration can be promoted to be applied to hair removal section on the left of each group cavy (1g/ is only), continue 6h.
7d and 14d, is in kind retried once.
Excite contact：The 14d after last is to tested material sensitization, the emulsion that skin regeneration can be promoted respectively by taking is applied to each group globefish
Remove tested material after hair removal section on the right side of mouse, 6h, observe at once, then observe cutaneous anaphylaxis feelings again in 24h, 48h, 72h
Condition.Hypersensitive reacts standards of grading with the skin wound repair standards of grading of table 2, the hypersensitive evaluation criterion such as institute of table 5
Show.Sensitivity response incidence=have allergic reaction number of animals (no matter degree weight)/animal number × 100%.
4th, result of the test
Result of the test is as shown in table 6.
Table 5：Hypersensitive evaluation criterion
| Allergy incidence (%) | Stimulus intensity rank |
| 0~10 | Without sensitization |
| 11~30 | Slight sensitization |
| 31~60 | Moderate sensitization |
| 61~80 | Height sensitization |
| 81~100 | Extreme sensitization |
Table 6：The emulsion of skin regeneration can be promoted to guinea pig skin allergic reaction result of the test
As can be seen from Table 6,1 group of the embodiment of the present invention, 2 groups of embodiment, 3 groups of embodiment are in 0h, 24h, 48h and 72h
Average allergic reaction score value is 0, and sensitization incidence is 0.And the average allergic reaction of 2 groups of 1 group of comparative example and comparative example point
Value is apparently higher than embodiment 1-3 groups, and sensitization incidence is respectively 20% and 30%.This explanation, the present invention can promote skin regeneration
Emulsion without sensitization, it is safe and reliable.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (9)
1. a kind of emulsion for promoting skin regeneration, it is characterised in that including following components and its parts by weight：
3-6 parts of Sweet Almond Oil, 0.3-0.6 parts of the benzene in Chinese mugwort ground, 1-2 parts of vitamin E, 2-3 parts of fibroin albumen, skin regeneration promoter
1-1.5 parts, 0.4-0.8 parts of skin penetration enhancer, change fragrant 0.2-0.4 parts of acid, 0.7-1.2 parts of sodium carboxymethylcellulose, L-
25-28 parts of 3-5 parts of pyrrolidone sodium carboxylate and deionized water.
2. the emulsion of skin regeneration can be promoted as claimed in claim 1, it is characterised in that including following components and its parts by weight
Number：
5 parts of Sweet Almond Oil, 0.4 part of the benzene in Chinese mugwort ground, 1.5 parts of vitamin E, 2.4 parts of fibroin albumen, 1.3 parts of skin regeneration promoter,
0.6 part of skin penetration enhancer, repeatedly fragrant 0.3 part of acid, 0.9 part of sodium carboxymethylcellulose and is gone 4 parts of PCA sodium
27 parts of ionized water.
3. the emulsion of skin regeneration can be promoted as claimed in claim 1 or 2, it is characterised in that the skin regeneration promoter
It is made up of chitosan oligosaccharide, basic fibroblast growth factor and barbaloin by weight 7-9: 4-6: 1-3.
4. the emulsion of skin regeneration can be promoted as claimed in claim 3, it is characterised in that the skin regeneration promoter is by shell
Oligosaccharides, basic fibroblast growth factor and barbaloin are by weight 8: 5: 2 compositions.
5. the emulsion of skin regeneration can be promoted as claimed in claim 1 or 2, it is characterised in that the skin penetration enhancer
It is made up of tetrahydrochysene pipering and Laurocapram by weight 4-6: 1-3.
6. the emulsion of skin regeneration can be promoted as claimed in claim 5, it is characterised in that the skin penetration enhancer is by four
Hydrogen pipering and Laurocapram are by weight 5: 2 compositions.
7. the preparation method of the emulsion for promoting skin regeneration as described in claim any one of 1-6, it is characterised in that including
Following steps：
S1 mixes Sweet Almond Oil, Chinese mugwort ground benzene, vitamin E, skin penetration enhancer, stirs, obtains oil phase；
S2 is by fibroin albumen, repeatedly fragrant acid, sodium carboxymethylcellulose, skin regeneration promoter and PCA sodium are mixed
Uniformly, it is added in deionized water, stirs to being completely dissolved, obtain aqueous phase；
Oil phase obtained by step S1 is added in aqueous phase obtained by step S2 by S3, carries out emulsifying, mixing speed is 1700-
1800r/min, the emulsifying time is 14-20 minutes, and vacuum defoamation is produced.
8. the preparation method of the emulsion of skin regeneration can be promoted as claimed in claim 7, it is characterised in that the step S3 is stirred
Speed is mixed for 1750r/min.
9. the preparation method of the emulsion of skin regeneration can be promoted as claimed in claim 7, it is characterised in that the step S3 is equal
Matter emulsification times are 18 minutes.
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Address after: 510360, No. 10 (6) building fifth, Yongsheng Road, Yonghe Economic Zone, Guangzhou economic and Technological Development Zone, Guangzhou, Guangdong Applicant after: Guangzhou rainbow pharmaceutical Polytron Technologies Inc Address before: 510730, No. 10 (6) building fifth, Yongsheng Road, Yonghe Economic Zone, Guangzhou economic and Technological Development Zone, Guangdong Applicant before: Guangzhou Rainhome Pharmaceutical Co., Ltd. |
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Application publication date: 20170714 |