IT202100021164A1 - FILLER COMPOSITION FOR INTRADERMAL IMPLANTS - Google Patents
FILLER COMPOSITION FOR INTRADERMAL IMPLANTS Download PDFInfo
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- IT202100021164A1 IT202100021164A1 IT102021000021164A IT202100021164A IT202100021164A1 IT 202100021164 A1 IT202100021164 A1 IT 202100021164A1 IT 102021000021164 A IT102021000021164 A IT 102021000021164A IT 202100021164 A IT202100021164 A IT 202100021164A IT 202100021164 A1 IT202100021164 A1 IT 202100021164A1
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- fibroin
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- intradermal
- antioxidants
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- 238000011200 topical administration Methods 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Description
Descrizione di Brevetto per Invenzione Industriale avente per titolo: Description of Patent for Industrial Invention having the title:
?COMPOSIZIONE RIEMPITIVA PER IMPIANTI INTRADERMICI?. ?FILLING COMPOSITION FOR INTRADERMAL IMPLANTS?.
DESCRIZIONE DESCRIPTION
La presente invenzione si riferisce ad una composizione riempitiva per impianti intradermici. The present invention relates to a filling composition for intradermal implants.
Gli impianti intradermici, i cosiddetti filler, sono trattamenti estetici utilizzati per contrastare i segni dell?invecchiamento cutaneo della pelle del viso oltre che le conseguenze di traumi e patologie sulla pelle. Intradermal implants, the so-called fillers, are aesthetic treatments used to counteract the signs of skin aging on the face as well as the consequences of trauma and pathologies on the skin.
Sono indispensabili per correggere difetti estetici o tratti non graditi agendo come ?riempitivi? in zone come mento, occhi, zigomi e labbra. They are indispensable for correcting aesthetic defects or unwelcome traits by acting as ?fillers? in areas such as the chin, eyes, cheekbones and lips.
Sono trattamenti scarsamente invasivi in grado di offrire dei risultati naturali ed ottimali. They are minimally invasive treatments able to offer natural and optimal results.
I trattamenti di filler viso sono molteplici e di diversa natura. Tali trattamenti consistono nell?iniezione intradermica di sostanze riempitive per correggere rughe, cicatrici da acne, difetti estetici e segni dell?aging. La nascita di questa disciplina risale agli anni ?60 e nel corso del tempo si ? consolidata e perfezionata sostituendo l?olio di silicone, ora bandito, con sostanze naturali quali il collagene o l?acido ialuronico. Facial filler treatments are many and of different nature. These treatments consist of the intradermal injection of filling substances to correct wrinkles, acne scars, aesthetic defects and signs of ageing. The birth of this discipline dates back to the 60s and over time consolidated and perfected by replacing the now banned silicone oil with natural substances such as collagen or hyaluronic acid.
L?evoluzione di questa branca della medicina estetica, inoltre, si ? affermata sempre pi? divenendo un rimedio medico ormai estremamente diffuso in numerose fasce della popolazione ed indispensabile soluzione per l?equilibrio psicofisico dei pazienti. Furthermore, the evolution of this branch of aesthetic medicine is established more and more becoming a medical remedy by now extremely widespread in many segments of the population and an indispensable solution for the psychophysical balance of patients.
In passato tra le sostanze maggiormente impiegate per i filler vi era il collagene, che sostitu? l?olio di silicone ritenuto dannoso per la salute dei pazienti. In the past, among the substances most used for fillers there was collagen, which substitute? silicone oil believed to be harmful to patients' health.
Tuttavia, il collagene portava a risultati scarsamente soddisfacenti e, per rimediare almeno in parte a tale inconveniente fu sostituito con l?acido ialuronico. However, collagen led to unsatisfactory results and, to remedy at least part of this drawback, it was replaced with hyaluronic acid.
Anche l?acido ialuronico non ? scevro di inconvenienti, tra i quali va annoverato il fatto che accade soventemente che, a seguito dell?inoculo, causi la formazione di granulomi successivamente allo sviluppo di una reazione infiammatoria dei tessuti circostanti la sede di inoculo. Even hyaluronic acid is not? free from drawbacks, including the fact that it often happens that, following the inoculation, it causes the formation of granulomas following the development of an inflammatory reaction of the tissues surrounding the inoculation site.
In aggiunta, l?impiego di acido ialuronico causa la formazione di microtrombi nella sede di inoculo conseguente al facile sanguinamento con successiva formazione di agglomerati piastrinici. In addition, the use of hyaluronic acid causes the formation of microthrombi in the injection site following easy bleeding with the subsequent formation of platelet agglomerates.
Inoltre, l?impiego di acido ialuronico presenta un rapido consumo nel tempo dovuto ai cicli metabolici cutanei differenti in funzione della sede di inoculo. Furthermore, the use of hyaluronic acid presents a rapid consumption over time due to the different cutaneous metabolic cycles according to the injection site.
Infine, l?utilizzo di filler a base di acido ialuronico presenta numerose controindicazioni nei confronti di pazienti presentanti cute lesionata, affezioni virali ed erpetiche locali o sistemiche, collagenopatie, malattie cutanee, patologie autoimmuni, gravidanza e allattamento. Finally, the use of hyaluronic acid-based fillers has numerous contraindications in patients with damaged skin, local or systemic viral and herpetic diseases, collagen diseases, skin diseases, autoimmune diseases, pregnancy and breastfeeding.
Il compito principale della presente invenzione ? quello di escogitare una composizione riempitiva per impianti intradermici che sia biocompatibile e riduca il rischio di formazione di trombi favorendo la neovascolarizzazione tissutale. The main task of the present invention ? that of devising a filling composition for intradermal implants that is biocompatible and reduces the risk of thrombus formation by promoting tissue neovascularization.
Uno scopo del presente trovato ? quello di escogitare una composizione riempitiva per impianti intradermici che ne permetta la somministrazione a pazienti affetti da cute lesionata o da patologie virali, erpetiche, o collagenopatie. A purpose of the present invention ? that of devising a filling composition for intradermal implants which allows their administration to patients affected by damaged skin or by viral, herpetic or collagen pathologies.
Un ulteriore scopo del presente trovato ? quello di escogitare una composizione riempitiva per impianti intradermici che sia somministrabile a pazienti gravide, o in allattamento o a pazienti affetti da patologie autoimmuni. Another object of the present invention ? that of devising a filler composition for intradermal implants which can be administered to pregnant or nursing patients or to patients suffering from autoimmune diseases.
Altro scopo del presente trovato ? quello di escogitare una composizione riempitiva per impianti intradermici che consenta di superare i menzionati inconvenienti della tecnica nota nell?ambito di una soluzione semplice, razionale, di facile ed efficace impiego e dal costo contenuto. Another object of the present invention ? that of devising a filling composition for intradermal implants which allows the aforementioned drawbacks of the prior art to be overcome within the scope of a simple, rational, easy and effective solution to use and with a low cost.
Gli scopi sopra esposti sono raggiunti dalla presente composizione riempitiva per impianti intradermici avente le caratteristiche di rivendicazione 1. The above objects are achieved by the present filling composition for intradermal implants having the characteristics of claim 1.
Inoltre, gli scopi sopra esposti sono raggiunti dal kit per il trattamento cutaneo di atrofie avente le caratteristiche di rivendicazione 8. Furthermore, the above objects are achieved by the kit for the skin treatment of atrophies having the characteristics of claim 8.
In un primo aspetto, il presente trovato riguarda una composizione comprendente fibroina della seta presente in una concentrazione in peso superiore a 70%, acqua e uno o pi? antiossidanti. In a first aspect, the present invention relates to a composition comprising silk fibroin present in a concentration by weight greater than 70%, water and one or more substances. antioxidants.
Si specifica che se non altrimenti specificato ?percentuale (%) in peso? o ?concentrazione in peso? si riferisce al peso del singolo componente rispetto al peso totale della composizione. It is specified that if not otherwise specified ?percentage (%) by weight? or ?weight concentration? refers to the weight of the individual component relative to the total weight of the composition.
La seta ? un materiale proteico prodotto da differenti specie di artropodi. Quella impiegata proviene da un insetto, Bombyx Mori, tradizionalmente denominato baco da seta, ma tuttavia non si esclude che la fibroina sia ottenuta da altri lepidotti ed aracnidi. Silk ? a protein material produced by different arthropod species. The one used comes from an insect, Bombyx Mori, traditionally called silkworm, but however it is not excluded that the fibroin is obtained from other lepidocts and arachnids.
Vantaggiosamente, la fibroina ? fibroina rigenerata. Advantageously, the fibroin ? regenerated fibroin.
La fibroina della seta allo stato nativo presenta una struttura macromolecolare ordinata e cristallina con elevato livello di impaccamento delle singole catene polipeptidiche. Silk fibroin in its native state has an ordered and crystalline macromolecular structure with a high level of packing of the single polypeptide chains.
? doveroso sottolineare che la fibroina presenta alto potere di idratazione della pelle poich? ha alta propriet? igroscopica avendo anche lo stesso fattore di idratazione della pelle umana. ? It must be emphasized that fibroin has a high power of hydration of the skin since it has high property? hygroscopic also having the same hydration factor of human skin.
Inoltre, la fibroina evita reazioni di rigetto da parte del sistema immunitario, essendo quest?ultima biodegradabile e riassorbibile entro un anno. Furthermore, fibroin avoids reactions of rejection by the immune system, being the latter biodegradable and reabsorbable within a year.
In aggiunta, l?impiego di fibroina permette gli scambi di ossigeno e favorisce l?equilibrio idrolipidico. In addition, the use of fibroin allows oxygen exchanges and promotes hydrolipidic balance.
Al fine di ottenere una composizione riempitiva in cui la fibroina abbia morfologie diverse da quella assunta dalla proteina allo stato nativo, ? necessaria la disgregazione di questa struttura altamente ordinata e compatta attraverso l?uso di un solvente in grado di rigonfiare le fibre, diffondere al loro interno e rompere i ponti idrogeno senza incorrere nella degradazione delle molecole di fibroina. In order to obtain a filler composition in which the fibroin has different morphologies from the one assumed by the protein in its native state, ? The disintegration of this highly ordered and compact structure is necessary through the use of a solvent capable of swelling the fibers, diffusing inside them and breaking the hydrogen bridges without incurring in the degradation of the fibroin molecules.
Solitamente ci? si ottiene ponendo le fibre in soluzioni saline concentrate a 65?C e la soluzione ottenuta viene successivamente dializzata con 26 membrane fino a completa eliminazione dei sali. La fibroina risultante si trova nella conformazione silk I, instabile e solubile. La conformazione silk II deve essere poi ricostituita durante la fase di rigenerazione per rendere il materiale insolubile nel medium fisiologico e perci? adatto all?impiego nel settore biomedico. I metodi di rigenerazione sono diversi a seconda che si vogliano ottenere film, idrogeli, reti o scaffold 3D della proteina. Usually there? it is obtained by placing the fibers in concentrated saline solutions at 65°C and the solution obtained is subsequently dialysed with 26 membranes until complete elimination of the salts. The resulting fibroin is in the silk I conformation, unstable and soluble. The silk II conformation must then be reconstituted during the regeneration phase to make the material insoluble in the physiological medium and therefore? suitable for use in the biomedical sector. The regeneration methods are different depending on whether the protein films, hydrogels, networks or 3D scaffolds are to be obtained.
La composizione in accordo con il trovato ? in forma di idrogel. The composition in accordance with the invention ? in hydrogel form.
In generale, il tempo di gelificazione diminuisce con l?aumento della concentrazione di fibroina. In general, gelling time decreases with increasing fibroin concentration.
Preferibilmente, la fibroina ? presente in una concentrazione in peso, valutata rispetto al peso complessivo della composizione, superiore a 80%. Vantaggiosamente, la fibroina ? presente in una concentrazione in peso sostanzialmente pari a 85%. Preferably, the fibroin ? present in a concentration by weight, evaluated with respect to the total weight of the composition, greater than 80%. Advantageously, the fibroin ? present in a concentration by weight substantially equal to 85%.
A questo proposito, la composizione riempitiva in accordo con il presente trovato, grazie alla suddetta concentrazione di fibroina consente di ottenere un lento assorbimento da parte del corpo umano, permettendo un prolungato tempo di permanenza della composizione riempitiva stessa, ossia del filler, nel sito di somministrazione, cio? di iniezione. In this regard, the filler composition in accordance with the present invention, thanks to the aforementioned concentration of fibroin, allows to obtain a slow absorption by the human body, allowing a prolonged residence time of the filler composition itself, i.e. of the filler, in the site of administration, what? of injection.
Ci? consente di ridurre notevolmente, o addirittura eliminare, i successivi trattamenti riempitivi, i cosiddetti ?re-filling?. There? allows to significantly reduce, or even eliminate, the subsequent filling treatments, the so-called ?re-filling?.
Inoltre, gli uno o pi? antiossidanti sono scelti dall?elenco comprendente: vitamina a E e tocoferoli. Furthermore, the one or more antioxidants are chosen from the list including: vitamin a E and tocopherols.
Preferibilmente, gli uno o pi? antiossidanti sono presenti in una concentrazione in peso superiore a 10%. Preferably, the one or more? antioxidants are present in a concentration by weight greater than 10%.
Vantaggiosamente, gli uno o pi? antiossidanti sono presenti in una concentrazione in peso sostanzialmente pari a 15%. Advantageously, the one or more? antioxidants are present in a concentration by weight substantially equal to 15%.
In un secondo aspetto, la presente invenzione riguarda la composizione sopra descritta per l?uso come sostanza attiva nel trattamento terapeutico e/o cosmetico di atrofie, cicatrici e cheloidi. In a second aspect, the present invention relates to the composition described above for use as an active substance in the therapeutic and/or cosmetic treatment of atrophies, scars and keloids.
Vantaggiosamente, le atrofie comprendono rughe, cedimenti cutanei. Advantageously, atrophies include wrinkles, sagging skin.
In un secondo aspetto, il presente trovato riguarda un kit per il trattamento cutaneo di atrofie comprendente: In a second aspect, the present invention relates to a kit for the skin treatment of atrophies comprising:
- la composizione riempitiva per somministrazione intradermica; - the filler composition for intradermal administration;
- una composizione ausiliaria per applicazione topica comprendente una soluzione acquosa e fibroina presente in una concentrazione in peso superiore al 50% ed almeno un emolliente. - an auxiliary composition for topical application comprising an aqueous solution and fibroin present in a weight concentration higher than 50% and at least one emollient.
Vantaggiosamente, l?emolliente ? scelto dall?elenco comprendente: olio di mandorle, olio di rosa mosqueta. Advantageously, the emollient? chosen from the list including: almond oil, rosehip oil.
In aggiunta, la composizione ausiliaria comprende retinolo. Additionally, the auxiliary composition comprises retinol.
Nel dettaglio, la somministrazione della composizione ausiliaria ? eseguita per via topica e in combinazione con la somministrazione intradermica della composizione riempitiva. In detail, the administration of the auxiliary composition ? performed topically and in combination with intradermal administration of the filler composition.
La composizione ausiliaria agisce a livello intradermico favorendo il ripristino della normale fisiologia volumetrica tissutale. The auxiliary composition acts intradermally favoring the restoration of normal tissue volumetric physiology.
Inoltre, il kit in accordo con il trovato comprende una compressa comprendente fibroina rigenerata, vitamina E, retinolo e olio di rosa mosqueta. Furthermore, the kit according to the invention comprises a tablet comprising regenerated fibroin, vitamin E, retinol and rosehip oil.
Tali compresse sono rivestite, inoltre, di un involucro di amido di mais. Si ? in pratica constatato come l?invenzione descritta raggiunga gli scopi proposti. These tablets are also coated with a corn starch shell. Yes ? in practice it has been observed that the described invention achieves the proposed aim and objects.
In particolare, si sottolinea il fatto che l?impiego di fibroina consente la realizzazione di un filler biocompatibile, resistente, flessibile e non estensibile. In particular, the fact is underlined that the use of fibroin allows the creation of a biocompatible, resistant, flexible and non-extensible filler.
In aggiunta, la sinergica combinazione di fibroina con uno o pi? antiossidanti consente di promuovere l?adesione cellulare alla superficie del filler accelerandone la crescita e stimolandone la replicazione. In addition, the synergistic combination of fibroin with one or more? antioxidants allows to promote cell adhesion to the surface of the filler, accelerating its growth and stimulating its replication.
Inoltre, la sinergica combinazione di fibroina con uno o pi? antiossidanti consente di promuovere la sintesi di collagene stimolando la produzione di acido ialuronico a livello dermico. Furthermore, the synergistic combination of fibroin with one or more? antioxidants helps promote collagen synthesis by stimulating the production of hyaluronic acid at the dermal level.
Ancora, la suddetta combinazione espleta azione antibatterica ed antimicotica attraverso la sua capacit? di inattivare gli agenti patogeni che, entrando in contatto con la fibroina, subiscono la distruzione della loro membrana cellulare impedendo il formarsi di colonie batteriche. Again, the aforementioned combination performs antibacterial and antifungal action through its ability to to inactivate the pathogens which, coming into contact with the fibroin, undergo the destruction of their cell membrane, preventing the formation of bacterial colonies.
Tale combinazione consente, inoltre, di ridurre il rischio di formazione di trombi favorendo la neovascolarizzazione tissutale. This combination also reduces the risk of thrombus formation by promoting tissue neovascularization.
Ancora, la fibroina ? biodegradabile e, di conseguenza, degradandosi si scompone negli amminoacidi costitutivi che vengono riassorbiti a livello dermico senza provocare alcuno stato infiammatorio, ma stimolando la fisiologia tissutale. Again, the fibroin ? biodegradable and, consequently, degrading it breaks down into the constituent amino acids which are reabsorbed at the dermal level without causing any inflammatory state, but stimulating tissue physiology.
Infine, ? doveroso sottolineare che l?impiego di un impianto intradermico in combinazione con una composizione ausiliaria ad applicazione topica consente l?applicazione di quest?ultima sulla cute sensibile, allergica, iperattiva, favorendo l?equilibrio idrolipidico e garantendo il mantenimento dell?idratazione cutanea grazie alle sue propriet? igroscopiche. In the end, ? It must be emphasized that the use of an intradermal implant in combination with an auxiliary composition for topical application allows the application of the latter on sensitive, allergic, hyperactive skin, favoring the hydrolipidic balance and guaranteeing the maintenance of skin hydration thanks to the its properties? hygroscopic.
Inoltre, si enfatizza che la sinergica combinazione di fibroina e antiossidanti consente di ridurre la sensazione di bruciore, irritazione, eritema e dolore associati all?applicazione intradermica, prevenendo le frequenti ricadute di affezioni cutanee. Furthermore, it is emphasized that the synergistic combination of fibroin and antioxidants reduces the burning sensation, irritation, erythema and pain associated with intradermal application, preventing the frequent relapses of skin diseases.
Ci? ? dovuto alla sorprendente capacit? termoregolativa associata alla suddetta combinazione di sostanze che consente un efficiente scambio di ossigeno, evitando di causare tossicit? cutanea e sistemica. There? ? due to the surprising ability? thermoregulatory associated with the aforementioned combination of substances that allows an efficient exchange of oxygen, avoiding causing toxicity? cutaneous and systemic.
Il fatto di impiegare sostanze biocompatibili e di origine naturale permette l?impiego di queste ultime anche in gravidanza e allattamento. The fact of using biocompatible substances of natural origin allows them to be used even during pregnancy and breastfeeding.
Infine, la combinazione di fibroina insieme ad antiossidanti consente di realizzare una composizione resistente alle alte temperature senza modificarsi e, conseguentemente, resistente anche alle temperature di sterilizzazione. Finally, the combination of fibroin together with antioxidants allows to obtain a composition resistant to high temperatures without modification and, consequently, also resistant to sterilization temperatures.
Claims (10)
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| IT102021000021164A IT202100021164A1 (en) | 2021-08-04 | 2021-08-04 | FILLER COMPOSITION FOR INTRADERMAL IMPLANTS |
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| IT102021000021164A IT202100021164A1 (en) | 2021-08-04 | 2021-08-04 | FILLER COMPOSITION FOR INTRADERMAL IMPLANTS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943316A (en) * | 2017-05-23 | 2017-07-14 | 广州润虹医药科技有限公司 | Emulsion of skin regeneration and preparation method thereof can be promoted |
| WO2017137937A1 (en) * | 2016-02-10 | 2017-08-17 | Jawaharlal Nehru Centre For Advanced Scientific Research | A composite, scaffold and applications thereof |
| CN107375031A (en) * | 2017-08-04 | 2017-11-24 | 江苏安吉雅日化有限公司 | A kind of skin cream and its production technology |
| WO2020247887A1 (en) * | 2019-06-06 | 2020-12-10 | Evolved By Nature, Inc. | Silk stimulated collagen production and methods of use thereof |
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2021
- 2021-08-04 IT IT102021000021164A patent/IT202100021164A1/en unknown
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| WO2017137937A1 (en) * | 2016-02-10 | 2017-08-17 | Jawaharlal Nehru Centre For Advanced Scientific Research | A composite, scaffold and applications thereof |
| CN106943316A (en) * | 2017-05-23 | 2017-07-14 | 广州润虹医药科技有限公司 | Emulsion of skin regeneration and preparation method thereof can be promoted |
| CN107375031A (en) * | 2017-08-04 | 2017-11-24 | 江苏安吉雅日化有限公司 | A kind of skin cream and its production technology |
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