CN102755467B - Rochas winter ointment for treating frostbite and preparation method thereof - Google Patents

Abstract

The invention discloses rochas winter ointment for treating frostbite and a preparation method thereof. The rochas winter ointment is prepared by mistletoe, ardisia mamillata, basil, oenothera odorata, rubus parvifolius oil, amaranthus caudatus and ampelopsis aconitifolia by weight. The rochas winter ointment has functions of clearing away heat and toxic materials, promoting granulation, relieving pain, removing carbuncle and stasis, is used for treating the frostbite, and is good in curative effect, rapid in effect production and high in cure rate.

Description

A kind of Luo Shadong ointment for the treatment of cold injury and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of cold injury and preparation method thereof, belong to the field of Chinese medicines.

Background technology

In cold season, or in the environment of low temperature and moisture the time oversize, if health resisting cold protection is improper, just part frozen or whole body cold injury can occur.At present, the kibe ointment of selling on market can only be alleviated and can not cure fully chilblain, and suffers from the people of chilblain last year, just easily sends out later on again.Therefore, there is very large demand in the patient to the Chinese medicine of effective treatment cold injury.

Summary of the invention

The inventor has finally found the Chinese medicine of effective treatment cold injury, thereby has completed the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just is to provide a kind of Chinese medicine composition that can effectively treat cold injury.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Herba Visci, Ardisia mamillata, Radix Solani Melongenae, Caulis et Folium Ammopiptanthi Mongolici, Radix Glycosmidis Citrifoliae, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, Radix Oenotherae erythrosepalae oil, Rubus Parvifolius L. oil, amaranthus caudatus, Bulbus et Radix Crini Sinici, ampelopsis aconitifolia to make up, make each efficacy of drugs produce synergism these drug regimens, thus can the fast treating cold injury.Wherein select Herba Visci to be because its nature and flavor are sweet, bitter, property is flat, invigorating the liver and kidney is arranged, bone and muscle strengthening, wind-damp dispelling, the function of nourishing YIN and benefiting blood.Be used for rheumatic arthritis, aching pain in waist and back, essential hypertension, frequent fetal movement, cough, cold injury.Select Ardisia mamillata to be because its nature and flavor are bitter, cool in nature, clearing away heat-damp and promoting diuresis is arranged, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain, the function of removing the necrotic tissue and promoting granulation.Be used for spitting blood, have blood in stool, furuncle.Select Radix Solani Melongenae to be because its nature and flavor are sweet, light, property is flat, clearing away heat-damp and promoting diuresis is arranged, wind dispelling cough-relieving, anastaltic function.Be used for rheumatic arthritis, the senile chronic tracheitis, poliomyelitis, edema, chronic cough, chronic dysentery, leucorrhea, seminal emission, hematuria is had blood in stool.Select Caulis et Folium Ammopiptanthi Mongolici to be because its nature and flavor are hot, bitter, warm in nature, poisonous, expelling wind and removing dampness is arranged, the function of promoting blood circulation to remove blood stasis.Be used for cold injury, chronic rheumatic arthralgia.Select Radix Glycosmidis Citrifoliae to be because its root: acrid in the mouth, warm in nature, leaf: sweet in the mouth, tepor has expelling phlegm for arresting cough, the removing food stagnancy of regulating the flow of vital energy, the function of scattered silt detumescence.Be used for cold cough, dyspepsia, inappetence, colic, external traumatic injury congestion swells and ache.Select amaranthus caudatus to be because its nature and flavor are sweet, light, root has the function of strengthening by means of tonics, and seed has detumescence, the function of pain relieving.Seed is used for traumatic injury, and fracture swells and ache, the malignant boil toxic swelling, and root is used for dizzy, myasthenia of limbs, infantile malnutrition.Select Bulbus et Radix Crini Sinici to be because its nature and flavor are hot, cool in nature, slightly poisonous, the detoxifcation scattered silt is arranged, the function of reducing swelling and alleviating pain.Leaf is used for carbuncle sore tumefacting virus, injury and bone fracture, and headache, arthralgia, bulb is used for cough, laryngalgia, traumatic injury.Select ampelopsis aconitifolia to be because its nature and flavor are bitter, flavor is slightly cold, and heat-clearing and toxic substances removing is arranged, granulation promoting pain relieving edema, the function of eliminating carbuncle eliminating stagnation.Be used for anemofrigid-damp arthralgia, traumatic injury becomes silted up swollen, ulcer sore pain.select the Herba Ocimi (Herba Ocimi Pilosi) quintessence oil to be because its main component is ocimene (Ocimene), australene (α-Pinene), 1, 8-cineole (1, 8-Cineole, Eucalyptole), labor Camphor tree alcohol (Linalool), Geraniol (Geraniol), limonene (Limonene), carene-3 (⊿ 3-Carene), estragole (Methylchavicol), eugenol (Eugenol), methyleugenol (Eugenol methyl ether), methoxybenzene (Anethole), methyl cinnamate (Methyl cinnaminate), hexene-3-ol-1(3-Hexen-1-ol), octanone-3(3-Octanone) and furfural (Furfural) etc., contain volatile oil 0.02-0.04%, the extraction of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil is from blade and fresh idea, be colourless quintessence oil, abnormal smells from the patient is refrigerant, nervous system there is very strong stimulation, use when tired and inspire enthusiasm immediately, focus one's attention on, mouthfeel is fresh and sweet, slightly hot flavor.The Herba Ocimi (Herba Ocimi Pilosi) quintessence oil also has the improvement of tightening up and blocks skin, control acne, control that head and migraine, flu, digestion are abnormal, myalgia, can stimulate the estrogen secretion, be used for opsomenorrhea, prolonged not under, also can be used for cough, rheumatism, puerpera's postpartum lactescence quantity not sufficient, carsickness is seasick etc., it can treat various respiratory tract infection, also can alleviate stomach spasm or reduce cold injury.Dryness hydropenia or aging skin coarse, wrinkle there are the effect of moistening, also can be used for frequent overtime work and long-term black eye, eye pouch in the face of the computer appearance.The Herba Ocimi (Herba Ocimi Pilosi) quintessence oil has stronger medical value, its nature and flavor are hot, warm, has relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness, the function of eliminating stasis to stop pain, be used for anemofrigid cold, headache, pipe abdomen fullness, dyspepsia, stomachache, enteritis, diarrhea, treating swelling and pain by traumatic injury, rheumatic arthritis, external curing venom, eczema, dermatitis.

Select Radix Oenotherae erythrosepalae oil to be because evening primrose seed oil contains abundant linolenic acid, function with blood fat reducing, bone and muscle strengthening, wind-damp dispelling, the medicine that is mixed with can cure mainly the diseases such as coronary heart disease, hypertension, arteriosclerosis, obesity, rheumatic arthritis, dermatitis, bones and muscles pain.

Select Rubus Parvifolius L. oil to be because the bacteriostatic activity of radix rubi parvifol and leaf volatile oil.

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope:

Herba Visci 5-7 gram Ardisia mamillata 3-5 gram Radix Solani Melongenae 3-6 grams

Quintessence oil 5-10 grams are strangled in Caulis et Folium Ammopiptanthi Mongolici 10-15 gram Radix Glycosmidis Citrifoliae 2-4 Crows

Radix Oenotherae erythrosepalae oil 25-35 gram Rubus Parvifolius L. oil 10-15 gram amaranthus caudatus 2-6 grams

Bulbus et Radix Crini Sinici 3-7 gram ampelopsis aconitifolia 4-10 grams

Preferable amount is

Herba Visci 6 gram Ardisia mamillata 4 gram Radix Solani Melongenae 5 grams

Quintessence oil 7 grams are strangled in Caulis et Folium Ammopiptanthi Mongolici 12 gram Radix Glycosmidis Citrifoliae 3 Crows

Radix Oenotherae erythrosepalae oil 30 gram Rubus Parvifolius L. oil 12 gram amaranthus caudatus 5 grams

Bulbus et Radix Crini Sinici 5 gram ampelopsis aconitifolia 8 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Herba Visci: choose decontamination, clean, dry;

2, Ardisia mamillata: except the dedust bits;

3, Radix Solani Melongenae: choose decontamination, except the dedust bits;

4, Caulis et Folium Ammopiptanthi Mongolici: except the dedust bits, standby;

5, Radix Glycosmidis Citrifoliae: remove impurity, clean, dry;

6, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get stem and leaf, the flower core herb of Herba Ocimi (Herba Ocimi Pilosi) plant, remove root, mud, rotted leaf, impurity, dry, extract quintessence oil;

7, Radix Oenotherae erythrosepalae oil: get Radix Oenotherae erythrosepalae, remove impurity, clean, dry, oil expression;

8, Rubus Parvifolius L. oil: get Rubus Parvifolius L., remove impurity, clean, dry, oil expression;

9, amaranthus caudatus: choose decontamination, except the dedust bits;

10, Bulbus et Radix Crini Sinici: choose decontamination, except the dedust bits;

11, ampelopsis aconitifolia: choose decontamination, except the dedust bits.

Two, preparation

1, with Radix Solani Melongenae, the amaranthus caudatus grind into powder of described weight.

2, Radix Oenotherae erythrosepalae, Rubus Parvifolius L. are put into respectively juice extractor and squeeze, squeeze respectively Radix Oenotherae erythrosepalae oil, Rubus Parvifolius L. oil.

3, Herba Ocimi (Herba Ocimi Pilosi) is dropped in sedimentation tank with Alumen water soaking 2-3 hours, the weight ratio of water and Alumen is 1:0.0002.Put into boiler after cleaning with clean water, the addition of raw material is 80-90% of boiler volume, and amount of water was as the criterion to soak raw material.To carrying out vapor distillation 60-80 minutes at the bottom of boiler, collect the oil reservoir that oil water separator is separated, then pass through purification filtering, namely obtain pure natural Herba Ocimi (Herba Ocimi Pilosi) quintessence oil.

4, Herba Visci, Ardisia mamillata, Caulis et Folium Ammopiptanthi Mongolici, Radix Glycosmidis Citrifoliae, tail fringe orchid, Bulbus et Radix Crini Sinici, ampelopsis aconitifolia are decocted with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, namely got decoction liquor for the first time in 20 minutes with slow fire boiling again, decoction liquor is poured in container for the first time.Medicinal residues after filtering are for the first time added 2 times of amounts of water, first boil with high heat, then used slow fire boiling 20 minutes, decoction liquor is poured in container for the second time, and twice decoction liquor carried out mixing and stirring, then gets mixed liquor in 20 minutes with slow fire boiling.

5, the powder that above medicine is ground, the mixed liquor of extraction, the Herba Ocimi (Herba Ocimi Pilosi) quintessence oil of distillation and the Radix Oenotherae erythrosepalae oil that squeezes, Rubus Parvifolius L. oil mixing and stirring are made ointment, namely get Luo Shadong ointment of the present invention.

Medicine of the present invention has heat-clearing and toxic substances removing, granulation promoting pain relieving edema, the function of eliminating carbuncle eliminating stagnation.Be used for the treatment of cold injury, good effect, instant effect, cure rate are high, do not recur.

The specific embodiment

Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.4kg is with the cotton swab that is immersed in acetic acid, be pressed in the abdominal part that pulls out the clean rabbit hair and make film 20 seconds, make mucosa diameter 5mm, divide two groups with rabbit after making film, every group 15, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is every day 5 times, and normal amount is every day 2 times, and administering mode is the application administration, connects to apply 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] Drug therapy cold injury of the present invention:

1, physical data

Accept out-patient's totally 503 examples for medical treatment, light-duty class patient's 330 examples wherein, heavy class patient's 173 examples.

2, diagnostic criteria

Light-duty class cold injury: local skin is red and swollen, itch, causalgia, and vesicle appears in the part.

Heavy class cold injury: skin holostrome and subcutaneous tissue frost bitten, dermal sensation disappears, and edema and vesicle appear in the cold injury surrounding tissue, and more violent pain and bright the itching of companion.After coming off, slough leaves wound surface, easily secondary infection.

3, Therapeutic Method

Select above-mentioned ointment, give the outer spreading of patient affected part, light-duty class patient every day early, late external application 1 time, 7 days is a course for the treatment of, uses continuously 2 courses for the treatment of.The early, middle and late external application of heavy class patient 1 time, 7 days is a course for the treatment of, uses continuously 4 courses for the treatment of.

4, efficacy assessment standard

Produce effects: clinical symptom disappearance after treatment, affected part recover normal, observe half a year without the recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and progressively recover in the affected part;

Invalid: clinical partial symptoms disappears or without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with Drug therapy of the present invention light-duty class cold injury patient 503 examples, light-duty class patient's 330 examples wherein, produce effects 303 examples as a result, 27 examples that take a turn for the better, total effective rate is 100%.Heavy class patient 173 examples, produce effects 149 examples as a result, 16 examples that take a turn for the better, invalid 8 examples, total effective rate is 95.38%.

Claims (2)

1. Luo Shadong ointment for the treatment of cold injury, it is characterized in that: it is to be made by the crude drug in the following weight scope:

Herba Visci 5-7 gram Ardisia mamillata 3-5 gram Radix Solani Melongenae 3-6 grams

Quintessence oil 5-10 grams are strangled in Caulis et Folium Ammopiptanthi Mongolici 10-15 gram Radix Glycosmidis Citrifoliae 2-4 Crows

Radix Oenotherae erythrosepalae oil 25-35 gram Rubus Parvifolius L. oil 10-15 gram amaranthus caudatus 2-6 grams

Bulbus et Radix Crini Sinici 3-7 gram ampelopsis aconitifolia 4-10 grams.

2. treat according to claim 1 the Luo Shadong ointment of cold injury, it is characterized in that: wherein the consumption of each crude drug is:

Herba Visci 6 gram Ardisia mamillata 4 gram Radix Solani Melongenae 5 grams

Quintessence oil 7 grams are strangled in Caulis et Folium Ammopiptanthi Mongolici 12 gram Radix Glycosmidis Citrifoliae 3 Crows

Radix Oenotherae erythrosepalae oil 30 gram Rubus Parvifolius L. oil 12 gram amaranthus caudatus 5 grams

Bulbus et Radix Crini Sinici 5 gram ampelopsis aconitifolia 8 grams.