CN102657773A

CN102657773A - Medicament for treating appendicitis and preparation method thereof

Info

Publication number: CN102657773A
Application number: CN2012101786417A
Authority: CN
Inventors: 王光华; 王萍
Original assignee: 王光华
Priority date: 2012-06-03
Filing date: 2012-06-03
Publication date: 2012-09-12
Anticipated expiration: 2032-06-03
Also published as: CN102657773B

Abstract

The invention discloses a medicament for treating appendicitis and a preparation method thereof. The medicament is mainly prepared from moutan bark, dried rehamnnia root, honeysuckle, immature citron fruit, dried body of ground beetle, liquorice and Patrinia scaniosaefolia according to a certain weight proportion. The medicament disclosed by the invention has the functions of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, and dispersing carbuncle to removing stagnation, and has the advantages of good curative effect, quick acting and high cure rate for appendicitis.

Description

Typhlitic medicine of a kind of treatment and preparation method thereof

Technical field

The present invention relates to typhlitic medicine of a kind of treatment and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Appendicitis is a kind of common frequently-occurring disease, and performances such as right lower abdomen pain, fervescence, vomiting and neutrophilic leukocytosis are often arranged clinically.The performance of the typical clinical of acute appendicitis is a dull pain around the epigastrium that takes place gradually or the umbilicus, and stomachache is transferred to right lower abdomen after several hours.Often with inappetence, n or V, their early stage except that low grade fever, weak, do not have tangible General Symptoms more.Acute appendicitis is if early treatment not can develop into vermiform appendix gangrene and perforation, concurrent limitation or diffuse peritonitis.If delay diagnosis can cause severe complications with treatment, even causes death.

In a single day most acute appendicitiss are made a definite diagnosis, and all implement appendectomy, but operation risk are big, and expense is high, also be prone to cause complication, and it are bigger to take the influence of Western medicine antibiotic side effect.

Summary of the invention

Therefore people to curative effect preferably Chinese medicine have great demand, also do not find relevant report up to now at present about medicine of the present invention.The inventor has found the typhlitic medicine of quick curing finally, thereby has accomplished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

The typhlitic Chinese medicine composition of treatment that the object of the invention just provides a kind of evident in efficacy, taking convenience, has no side effect.

Another purpose of invention has just provided the method for preparing of this composition of medicine.

Medicine of the present invention selects Cortex Moutan, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga (different name Eupolyphaga Seu Steleophaga), Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, Folium Camelliae sinensis, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, Herba Patriniae to make up; Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat typhlitic recurrence.Wherein select for use Cortex Moutan to be because its nature and flavor are arduous, the heart, liver, kidney channel are gone in cold, and heat clearing away is arranged, removing heat from blood, and blood, and the function of repercussive is controlled the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer is pounced on damage.Select for use the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, go into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select for use the Radix Angelicae Dahuricae to be because its nature and flavor are hot, temperature is gone into lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the analgesic function is controlled headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select for use Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Select for use the Radix Aucklandiae to be because its nature and flavor are arduous, warm.Go into lung, liver, spleen channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, dysentery tenesmus, colic of cold type are had loose bowels in vomiting.Select for use Radix Bupleuri to be because its nature and flavor are bitter, be slightly cold, return liver, gallbladder meridian.Treating SHAO YANG disease by mediation, it is soothing the liver to bring down a fever, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.Select for use Flos Lonicerae to be because its nature and flavor are sweet, cold, go into lung, stomach warp, heat clearing away is arranged, the antidotal function is controlled the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select for use Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, go into spleen, stomach warp, dispelling the stagnated QI is arranged, the painful abdominal mass of loosing is rushed down expectorant, and the function of removing food stagnancy is controlled chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.It is salty because of its nature and flavor, cold, slightly poisonous selecting eupolyphaga for use.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Be used for the muscles and bones folding and hinder blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select for use Semen Persicae to be because its property bitter but sweet flavor is flat, go into the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selecting the Radix Paeoniae Alba for use is that liver, spleen channel are gone in cold, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select for use Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, go into spleen, stomach warp, control stagnantly, the function of strengthening the spleen and stomach is controlled the food stagnation distension, vomiting regurgitation, and dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Selecting Folium Camelliae sinensis for use is because of its property bitter but sweet flavor, cold.Go into the heart, lung, stomach warp.The refresh oneself, relieving thirst and restlessness is reduced phlegm, and helps digestion diuresis, detoxifcation.Control headache, blurred vision, kind the sleeping of sleeping more, restlessness and thirst, food stagnation expectorant stagnates, malaria, dysentery.Select for use Fructus Mume to be because its nature and flavor are sour, temperature is gone into liver, spleen, and lung, large intestine channel has convergence to promote the production of body fluid, and the anthelmintic function of relieving colic caused by ascaris is controlled chronic cough, the deficiency-heat excessive thirst, chronic malaria, dysentery is had blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Select for use Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, go into stomach, large intestine, liver footpath, the poison of purging heat is arranged, removing mass stagnates, and the function of clots absorbing blood is controlled the excess-heat constipation; Delirium is gone mad, the food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen; The time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema; Stranguria with turbid discharge, it is red to urinate, carbuncle and ulcer toxic swelling, furuncle, burn.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation; The function of coordinating the actions of various ingredients in a prescription is processed with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool; The overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle; Give birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select for use Herba Patriniae to be because its nature and flavor are hot, hardship, cold.Return stomach, large intestine, Liver Channel.Heat-clearing and toxic substances removing, removing blood stasis and expelling pus.Be used for appendicitis, dysentery, enteritis, hepatitis, eye conjunctivitis, postnatal blood stasis stomachache, carbuncle furuncle.

The consumption of composition of medicine of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range:

Cortex Moutan 10-20 gram Rhizoma Anemarrhenaes 12-20 gram Radixs Angelicae Dahuricae 10-20 grams

Radix Rehmanniae 10-20 gram Radix Aucklandiae 10-20 gram Radix Bupleuri 10-20 grams

Flos Lonicerae 25-35 gram Fructus Aurantii Immaturuss 10-15 gram eupolyphaga 10-15 grams

Semen Persicae 10-12 gram Radix Paeoniae Albas 5-12 gram Endothelium Corneum Gigeriae Galli 8-15 grams

Folium Camelliae sinensis 5-12 gram Fructus Mumes 8-12 gram Radix Et Rhizoma Rhei 8-15 grams

Radix Glycyrrhizae 5-8 gram Herba Patriniaes 90-110 grams

Wherein, be preferably

The Cortex Moutan 15 gram Rhizoma Anemarrhenaes 15 gram Radixs Angelicae Dahuricae 15 grams

The Radix Rehmanniae 15 gram Radix Aucklandiae 15 gram Radix Bupleuri 15 grams

Flos Lonicerae 30 gram Fructus Aurantii Immaturuss 12 gram eupolyphaga 12 grams

The Semen Persicae 10 gram Radix Paeoniae Albas 10 gram Endothelium Corneum Gigeriae Galli 10 grams

Folium Camelliae sinensis 10 gram Fructus Mumes 9 gram Radix Et Rhizoma Rhei 10 grams

Radix Glycyrrhizae 6 gram Herba Patriniaes 100 grams

The method for preparing of medicine of the present invention is following

One, gets the raw materials ready

1, Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;

2, the Rhizoma Anemarrhenae: choose decontamination, size separately is soaked in water to eighty per cant and passes through, and pulls out, and solarization is dried in the air, and profit to inside and outside humidity is even, section, drying;

3, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, moistening again, chip drying;

4, Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;

5, the Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, made softly in moistening 12-24 hour, section is dried;

6, Radix Bupleuri: get crude drug, remove residual stem, impurity is cleaned, and moisten softly, cuts sheet, and drying is sieved and removed chip;

7, Flos Lonicerae: sieve removes silt, chooses clean impurity;

8, Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant and pass through, pull out, profit to interior no hard-core, section is dried;

9, eupolyphaga: get crude drug, cleaning, drying;

10, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

11, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant and passes through, and pulls out, and solarization is dried in the air, and profit to inside and outside humidity is even, section, drying;

12, Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;

13, Folium Camelliae sinensis: get crude drug, remove impurity, branch stalk;

14, Fructus Mume: choose clean impurity, sieve dedust bits are cleaned, and dry;

15, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

16, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when eighty per cant passes through, pull out, run through section, dry;

17, Herba Patriniae: get crude drug, remove impurity, the water spray dries in the air cutting, drying slightly.

Two, preparation

1, Cortex Moutan, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga, Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, green tea, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Herba Patriniae of said weight are put into the medicine pot; Adding 3 times of amounts of clear water soaked 2 hours; Decoct boiling with high heat; Time decoction liquor of winning is filtered in reuse slow fire boiling 10 minutes.

2, filtered medicine liquid is poured out for the first time, adds 3 times of amounts of clear water again, decocts boiling with high heat, and reuse slow fire boiling 10 minutes is crossed and filtered the secondary decoction liquor.

3, secondary is decocted combining medicine, heating garment is used.To decoct combining medicine mix homogeneously in first time decoction liquor when taking for the first time for the second time, and pour out 500 milliliters again and take, and when taking for the second time, medicinal liquid will be placed on fire go up heating and can take.

Medicine of the present invention has reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, and the circulation of qi promoting removing heat from blood, heat-clearing and toxic substances removing, the effect of the carbuncle removing food stagnancy that looses is used to treat the appendicitis instant effect, and cure rate is high.

The specific embodiment

Below come further to set forth the beneficial effect of medicine of the present invention through Test Example, these Test Example comprise the report that animal toxicity test and clinical observation are tested.

The animal toxicity test report of [Test Example 1] medicine of the present invention:

Get 40 of West Germany rabbits, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is with behind the drug dilution, adopts the administration by gavage administration, and every day, secondary serve on 7 days, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [Test Example 2] medicine of the present invention:

1, physical data:

Accept out-patient's 350 examples for medical treatment, 35-40 years old 100 age example, 41-50 years old 120 example, 50-70 routine 130 examples.

2, diagnostic criteria:

Light-duty type appendicitis: morbidity is from the beginning of, patient bottom right abdomen pain, inappetence, and low grade fever is weak, n or V.

Heavy type appendicitis: dull pain around epigastrium or the umbilicus, stomachache shifts in right lower abdomen after several hours, and with inappetence, n or V symptom.

3, Therapeutic Method:

Oral: every day sooner or later each once, each 500 milliliters.Use warm boiled water ante cibum.Period in a medicine, the patient answers diet life, cold, stodge.Light-duty 1-3 day, heavy 4-5 day fully recovers.

4, efficacy assessment standard:

Produce effects: degree type class appendicitis is after treatment, and patient's colic symptoms disappears, and it is normal that patient's body constitution is recovered.Follow up a case by regular visits to unmanned recurrence in 1-10 years.

Take a turn for the better: patient's symptom progressively alleviates, and pain disappears, and feels good, and it is normal that body constitution is recovered basically.

Invalid: as not reach improvement standard person.

5, therapeutic outcome

In the treatment of 1-3 day, with light-duty appendicitis patient's 215 examples of Drug therapy of the present invention, produce effects 206 examples, 9 examples that take a turn for the better, total effective rate 100%; In the treatment of 4-5 day, with the heavy appendicitis patient of Drug therapy of the present invention 135 examples, produce effects 90 examples, 43 examples that take a turn for the better, total effective rate 98.50%.

Claims

1. treat typhlitic medicine for one kind, it is characterized in that: it is to be processed by the crude drug in the following weight range:

Radix Glycyrrhizae 5-8 gram Herba Patriniaes 90-110 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

The Radix Rehmanniae 15 gram Radix Aucklandiae 15 gram Radix Bupleuri 15 grams

Flos Lonicerae 30 gram Fructus Aurantii Immaturuss 12 gram eupolyphaga 12 grams

Radix Glycyrrhizae 6 gram Herba Patriniaes 100 grams.

3. the method for preparing of medicine according to claim 1 or claim 2, it comprises the following steps:

(1) gets the raw materials ready

(1) Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;

(2) Rhizoma Anemarrhenae: choose decontamination, size separately is soaked in water to eighty per cant and passes through, and pulls out, and solarization is dried in the air, and profit to inside and outside humidity is even, section, drying;

(3) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, moistening again, chip drying;

(4) Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;

(5) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, made softly in moistening 12-24 hour, section is dried;

(6) Radix Bupleuri: get crude drug, remove residual stem, impurity is cleaned, and moisten softly, cuts sheet, and drying is sieved and removed chip;

(7) Flos Lonicerae: sieve removes silt, chooses clean impurity;

(8) Fructus Aurantii Immaturus: choose clean impurity, be soaked in water to eighty per cant and pass through, pull out, profit to interior no hard-core, section is dried;

(9) eupolyphaga: get crude drug, cleaning, drying;

(10) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

(11) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant and passes through, and pulls out, and solarization is dried in the air, and profit to inside and outside humidity is even, section, drying;

(12) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;

(13) Folium Camelliae sinensis: get crude drug, remove impurity, branch stalk;

(14) Fructus Mume: choose clean impurity, sieve dedust bits are cleaned, and dry;

(15) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(16) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when eighty per cant passes through, pull out, run through section, dry;

(17) Herba Patriniae: get crude drug, remove impurity, the water spray dries in the air cutting, drying slightly;

(2) preparation

(1) Cortex Moutan, the Rhizoma Anemarrhenae, the Radix Angelicae Dahuricae, Radix Rehmanniae, the Radix Aucklandiae, Radix Bupleuri, Flos Lonicerae, Fructus Aurantii Immaturus, eupolyphaga, Semen Persicae, the Radix Paeoniae Alba, Endothelium Corneum Gigeriae Galli, green tea, Fructus Mume, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, the Herba Patriniae of said weight are put into the medicine pot; Adding 3 times of amounts of clear water soaked 2 hours; Decoct boiling with high heat; Time decoction liquor of winning is filtered in reuse slow fire boiling 10 minutes;

(2) filtered medicine liquid is poured out for the first time, adds 3 times of amounts of clear water again, decocts boiling with high heat, and reuse slow fire boiling 10 minutes is crossed and filtered the secondary decoction liquor;

(3) secondary is decocted combining medicine, heating garment usefulness is taken 500 grams at every turn.