CN102764344B - Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof - Google Patents
Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof Download PDFInfo
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Abstract
The invention discloses ointment containing basil essential oil, almond oil and grape seed oil for treating acne and a preparation method of the ointment. The ointment is mainly combined by dianthus chinensis, geranium sibiricum, ardisia mamillata, the basil essential oil, the almond oil and the grape seed oil. The medicines are combined to enable the medicine effects to generate a synergistic effect, so that the acne can be quickly treated and effectively removed.
Description
Technical field
The present invention relates to medicine of a kind of Acne treatment and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Acne is one of modal sick kind of Skin cosmesis, is mainly in adolescence, is again comedo, face Blisters or acne, is conventionally apt to occur in face, cervical region, chest and back, shoulder and upper arm.After adolescence, almost everyone can on the face or other positions gave birth to acne, show as pimple, blackhead, pustule, abscess, tuberosity, cyst, even cicatrix, often hinders attractive in appearance.Somebody seeks medical advice or own random controlling carelessly, so that sb.'s illness took a turn for the worse, produces more cicatrix, regrets to the very end of one's life.At present, doctor trained in Western medicine medication be take anti-inflammation as main, but some medicine that contains tetracycline, long-term taking can increase the weight of the burden of liver, kidney.Tretinoin medicines is the most effectively medicament categories of Acne treatment, and can accelerometer cornu cutaneum matter come off, keep the dry of skin, but easily decortication after using can not touch sunlight, and anemia of pregnant woman uses and also has the danger that causes teratogenesis.And physiotherapy adopts laser surgery treatment, risk is high, and actual effect is very poor.Therefore there is great demand to the Chinese medicine ointment of effective Acne treatment in patient.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the Chinese medicine of effective Acne treatment, thereby has completed the present invention.
Object of the present invention is just to provide a kind of effectively external used medicine of Acne treatment.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Dianthus chinensis, Pelargonium, Ardisia mamillata, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, almond oil, Oleum Vitis viniferae to combine, and makes each efficacy of drugs produce synergism these drug regimens, thereby can treating acne fast, effectively removes comedo.Wherein select Dianthus chinensis to be because its nature and flavor are bitter, cold in nature, have clearing away heat and promoting diuresis, promoting blood circulation to restore menstrual flow, the function of detumescence.For urinary tract infection, blood stasis amenorrhea, carbuncle skin ulcer pain.Select Pelargonium to be because its nature and flavor are bitter, pungent, property is flat, has wind-damp dispelling, promoting blood circulation to restore menstrual flow network, heat-clearing and toxic substances removing, the function of antidiarrheal dysentery.For rheumatic arthralgia, contracture is numb, carbuncle sore tumefacting virus, traumatic injury, enteritis and dysentery.Select Ardisia mamillata to be because its nature and flavor are bitter, cool in nature, have clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and hemostasis, the function of removing the necrotic tissue and promoting granulation.For spitting blood, have blood in stool, furuncle.Select Herba Ocimi (Herba Ocimi Pilosi) quintessence oil to be because select Herba Ocimi (Herba Ocimi Pilosi) quintessence oil to be because its main component is ocimene (Ocimene), australene (α-Pinene), 1, 8-cineole (1, 8-Cineole, Eucalyptole), labor Camphor tree alcohol (Linalool), Geraniol (Geraniol), limonene (Limonene), carene-3 (⊿ 3-Carene), estragole (Methylchavicol), eugenol (Eugenol), methyleugenol (Eugenol methyl ether), methoxybenzene (Anethole), methyl cinnamate (Methyl cinnaminate), hexene-3-ol-1(3-Hexen-1-ol), octanone-3(3-Octanone) and furfural (Furfural) etc., containing volatile oil 0.02-0.04%, the extraction of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil is from blade and fresh idea, for colourless quintessence oil, abnormal smells from the patient is refrigerant, nervous system is had to very strong stimulation, when tired, use and inspire enthusiasm immediately, focus one's attention on, mouthfeel is fresh and sweet, slightly pungent taste.Herba Ocimi (Herba Ocimi Pilosi) quintessence oil also has the improvement of tightening up and blocks skin, control acne, control that head and migraine, flu, digestion are abnormal, myalgia, can stimulate estrogen secretion, for opsomenorrhea, prolonged not under, also can be used for cough, rheumatism, puerpera's postpartum lactescence quantity not sufficient, carsickness is seasick etc., it can treat various respiratory tract infection, also can alleviate stomach spasm or reduce dysmenorrhea.Dryness hydropenia or aging skin coarse, wrinkle are had to the effect of moistening, also can be used for frequent overtime work and long-term black eye, eye pouch in the face of computer appearance.Herba Ocimi (Herba Ocimi Pilosi) quintessence oil has stronger medical value, its nature and flavor are pungent, warm, there is relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness, the function of eliminating stasis to stop pain, for anemofrigid cold, headache, pipe abdomen fullness, dyspepsia, stomachache, enteritis, diarrhea, treating swelling and pain by traumatic injury, rheumatic arthritis, external curing venom, eczema, dermatitis.Select almond oil to be because raw material Semen Armeniacae Amarum nature and flavor are bitter, temperature, poisonous.Enter lung, large intestine channel.Expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select Oleum Vitis viniferae to be because Semen Vitis viniferae contains Jiao's property catechol, Galla Turcica (Galla Helepensis) caffein, gallate etc.There is antiinflammatory, antibiotic effect.Oleum Vitis viniferae contains linoleic acid and proanthocyanidin.Linoleic acid can be resisted free radical, and aging resistance helps to absorb vitamin C and E, and the elasticity of strengthening blood circulation, reduces ultraviolet injury, and the collagen protein in protection skin, improves venous engorgement and edema, prevention melanin deposition.Proanthocyanidin has protection blood vessel elasticity, and protection skin avoids ultraviolet afflicting with great suffering torment, and the destruction of prevention collagen fiber and elastic fiber, makes skin keep due elasticity and tension force, avoids skin sagging and wrinkle to produce.Penetration is strong, and salubrious non-greasy, is very easily absorbed by the skin.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
3-6 grams of 5-6 grams of Ardisia mamillatas of 3-8 grams of Pelargoniums of Dianthus chinensis
20-25 grams of 30-35 grams of almond oil of 5-20 grams of Oleum Vitis viniferaes of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil
Preferable amount is
5 grams of 6 grams of Ardisia mamillatas of 6 grams of Pelargoniums of Dianthus chinensis
24 grams of 32 grams of almond oil of 15 grams of Oleum Vitis viniferaes of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Dianthus chinensis: remove impurity;
2, Pelargonium: remove impurity, clean, dry;
3, Ardisia mamillata: remove impurity, dry;
4, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get stem and leaf, the flower core herb of Herba Ocimi (Herba Ocimi Pilosi) plant, remove root, mud, rotted leaf, impurity, dry, extract quintessence oil;
5, almond oil: choose decontamination, put into oil press and squeeze almond oil;
6, Oleum Vitis viniferae: the Semen Vitis viniferae of removing epidermis sarcocarp is chosen only and dried, oil expression.
Two, preparation
1, the Dianthus chinensis of described weight, Pelargonium, Ardisia mamillata are decocted with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, then within 20 minutes, obtains decoction liquor for the first time with slow fire boiling, and decoction liquor is poured in container for the first time.Medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time.Twice decoction liquor carried out to mixing and stirring, then use slow fire boiling 20 minutes, obtain mixed liquor.
2, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) plant stem-leaf, pistil herb, remove root mud rotted leaf and impurity.Dry Herba Ocimi (Herba Ocimi Pilosi) is dropped in sedimentation tank and uses Alumen water soaking 2-3h, and the weight ratio of water and Alumen is 1:0.0002.After cleaning with clean water, put into boiler, the addition of raw material is 80-90% of boiler volume, and amount of water was as the criterion to soak raw material, and fresh and dry Herba Ocimi (Herba Ocimi Pilosi) plant will be distinguished steaming and decocting.To heating at the bottom of boiler, carry out vapor distillation, the stirring impeller of simultaneously opening in boiler overturns to raw material stirring, along with increasing of temperature, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil in plant material enters respectively in condenser along with steam produces the gas mixing with water through pot top gooseneck conduit, through condenser condenses, convert oil-water mixture to and be disposed in oil water separator, distillation time is 60-80 minutes.Collect the upper strata oil reservoir that oil water separator is separated, in the water of lower floor, contain a small amount of quintessence oil, be collected in container back warp and cross repetition distillation extraction recovery quintessence oil wherein, then pass through purification filtering, obtain pure natural Herba Ocimi (Herba Ocimi Pilosi) quintessence oil.
3, Semen Vitis viniferae, Semen Armeniacae Amarum are put into respectively to squeezer, get its oil, obtain respectively Oleum Vitis viniferae, almond oil.
4, the mixed liquor, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, Oleum Vitis viniferae, the almond oil mix and blend that said medicine are extracted are made ointment, are called for short sieve Portugal Fructus Pruni ointment.
Medicine of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and the function of removing the necrotic tissue and promoting granulation, in order to Acne treatment instant effect, good effect, cure rate is high.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, with the cotton swab being immersed in acetic acid, be pressed in the abdominal part 20Miao Zao Mo，Shi diameter 5-6mm of mucosa ulcer that pulls out the clean rabbit hair, by rabbit, divide two groups after making film, every group 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is every day 6 times, and normal amount is every day 2 times, and administering mode is application administration, connects and applies 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy burn of the present invention:
1, physical data
Accept out-patient's totally 422 examples for medical treatment, patients with mild 254 examples wherein, severe burn patients 168 examples.
2, diagnostic criteria
Patients with mild: be mainly pimple, pustule and blackhead.
Severe patient: skin lesion is a bunch collection property pimple, pustule, is maroon, very fast downright bad, with blood crusts, outbreak, forms netted cicatrix repeatedly.
3, Therapeutic Method
Select above-mentioned ointment, to patient, be applied to affected part.Slight patients with acne is smeared 2 times every day, early, respectively smear 1 evening, within 7 days, is a course for the treatment of, and 2 courses for the treatment of of external application continuously.Severe acne patient's external application every day 3 times, every day, early, middle and late respectively smearing 1 time, 7 days was a course for the treatment of, continuously 4 courses for the treatment of of external application.During use, with the clean affected part of warm water, ointment is applied in to affected part.
4, efficacy assessment standard
Effective: clinical symptom disappearance after treatment, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;
Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy fire victim's 422 examples of the present invention, its mild or moderate patients with acne 254 examples, effective 250 examples of result, obvious effective rate is 98.43%, 4 examples that take a turn for the better, and improvement rate is 1.57%, total effective rate is 100%.Severe acne patient's 168 examples, effective 156 examples of result, obvious effective rate is 92.86%, 12 examples that take a turn for the better, improvement rate is 7.14%, total effective rate is 100%.
Claims (3)
1. sieve Portugal Fructus Pruni ointment of Acne treatment, is characterized in that: it is to be made by the crude drug within the scope of following weight:
3-6 grams of 5-6 grams of Ardisia mamillatas of 3-8 grams of Pelargoniums of Dianthus chinensis
20-25 grams of 30-35 grams of almond oil of 5-20 grams of Oleum Vitis viniferaes of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil.
2. sieve Portugal Fructus Pruni ointment of Acne treatment according to claim 1, is characterized in that: wherein the consumption of each crude drug is:
5 grams of 6 grams of Ardisia mamillatas of 6 grams of Pelargoniums of Dianthus chinensis
24 grams of 32 grams of almond oil of 15 grams of Oleum Vitis viniferaes of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil.
3. according to the preparation method of sieve Portugal Fructus Pruni ointment of Acne treatment described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Dianthus chinensis: remove impurity;
(2) Pelargonium: remove impurity, clean, dry;
(3) Ardisia mamillata: remove impurity, dry;
(4) Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get stem and leaf, the flower core herb of Herba Ocimi (Herba Ocimi Pilosi) plant, remove root, mud, rotted leaf, impurity, dry, extract quintessence oil;
(5) almond oil: choose decontamination, put into oil press and squeeze almond oil;
(6) Oleum Vitis viniferae: the Semen Vitis viniferae of removing epidermis sarcocarp is chosen only and dried, oil expression;
(2) preparation
(1) Dianthus chinensis of described weight, Pelargonium, Ardisia mamillata are decocted with water, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, then within 20 minutes, obtains decoction liquor for the first time with slow fire boiling, and decoction liquor is poured in container for the first time; Medicinal residues after filtering are for the first time added to 2 times of amounts of water, first boil with high heat, then use slow fire boiling 20 minutes, decoction liquor is poured in container for the second time; Twice decoction liquor carried out to mixing and stirring, then use slow fire boiling 20 minutes, obtain mixed liquor;
(2) Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) plant stem-leaf, pistil herb, remove root mud rotted leaf and impurity, dry Herba Ocimi (Herba Ocimi Pilosi) is dropped in sedimentation tank with Alumen water soaking 2-3h, the weight ratio of water and Alumen is 1:0.0002, after cleaning with clean water, put into boiler, the addition of raw material is 80-90% of boiler volume, amount of water was as the criterion to soak raw material, fresh and dry Herba Ocimi (Herba Ocimi Pilosi) plant will be distinguished steaming and decocting, to heating at the bottom of boiler, carry out vapor distillation, the stirring impeller of simultaneously opening in boiler overturns to raw material stirring, along with increasing of temperature, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil in plant material enters respectively in condenser along with steam produces the gas mixing with water through pot top gooseneck conduit, through condenser condenses, converting oil-water mixture to is disposed in oil water separator, distillation time is 60-80 minutes, collect the upper strata oil reservoir that oil water separator is separated, in the water of lower floor, contain a small amount of quintessence oil, be collected in container back warp and cross repetition distillation extraction recovery quintessence oil wherein, pass through again purification filtering, obtain pure natural Herba Ocimi (Herba Ocimi Pilosi) quintessence oil,
(3) Semen Vitis viniferae, Semen Armeniacae Amarum are put into respectively to squeezer, get its oil, obtain respectively Oleum Vitis viniferae, almond oil;
(4) mixed liquor, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, Oleum Vitis viniferae, the almond oil mix and blend that said medicine are extracted are made sieve Portugal Fructus Pruni ointment.
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| CN201210279477.9A CN102764344B (en) | 2012-08-08 | 2012-08-08 | Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof |
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| CN201210279477.9A CN102764344B (en) | 2012-08-08 | 2012-08-08 | Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178237A (en) * | 2011-04-28 | 2011-09-14 | 永登苦水兴顺玫瑰花有限公司 | Kushui rose oil soft capsules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178237A (en) * | 2011-04-28 | 2011-09-14 | 永登苦水兴顺玫瑰花有限公司 | Kushui rose oil soft capsules |
Non-Patent Citations (5)
| Title |
|---|
| 吴小红等.用于化妆品中的植物.《国际中医中药杂志》.2006,第28卷(第1期),51-54. |
| 李宏.芳香疗法三则.《中国化妆品（行业版）》.2002,(第6期),74-86. * |
| 浅析痤疮古今用方之配伍规律;顾严严等;《中医药导报》;20100131;第16卷(第1期);78-80 * |
| 用于化妆品中的植物;吴小红等;《国际中医中药杂志》;20060131;第28卷(第1期);51-54 * |
| 顾严严等.浅析痤疮古今用方之配伍规律.《中医药导报》.2010,第16卷(第1期),78-80. |
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