CN102764344A - Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof - Google Patents
Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof Download PDFInfo
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- CN102764344A CN102764344A CN2012102794779A CN201210279477A CN102764344A CN 102764344 A CN102764344 A CN 102764344A CN 2012102794779 A CN2012102794779 A CN 2012102794779A CN 201210279477 A CN201210279477 A CN 201210279477A CN 102764344 A CN102764344 A CN 102764344A
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Abstract
The invention discloses ointment containing basil essential oil, almond oil and grape seed oil for treating acne and a preparation method of the ointment. The ointment is mainly combined by dianthus chinensis, geranium sibiricum, ardisia mamillata, the basil essential oil, the almond oil and the grape seed oil. The medicines are combined to enable the medicine effects to generate a synergistic effect, so that the acne can be quickly treated and effectively removed.
Description
Technical field
The present invention relates to a kind of medicine of treating acne and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Acne is one of modal sick kind of beauty treatment skin section, is mainly in puberty, is whelk, pimples or acne again, good usually sending out in face, neck, chest and back, shoulder and upper arm.After adolescence, almost everyone can on the face or other positions gave birth to acne, show as pimple, blackhead, pustule, abscess, tuberosity, cyst, even cicatrix, often hinder attractive in appearance.The somebody seeks medical advice or own random controlling carelessly, so that sb.'s illness took a turn for the worse, produces more cicatrix, regrets to the very end of one's life.At present, the doctor trained in Western medicine medication is main with anti-inflammation, but some contains the medicine of tetracycline, takes the burden that can increase the weight of liver, kidney for a long time.Tretinoin medicines is the most effectively drug kinds of treatment acne, but coming off of accelerometer cornu cutaneum matter keeps the drying of skin, but decortication easily after using can not touch sunlight, and the anemia of pregnant woman uses and also has the danger that causes teratogenesis.And physiotherapy adopts laser surgery treatment, and risk is high, and actual effect is very poor.Therefore, there is great demand in the patient to the Chinese medicine ointment of effective treatment acne.
Summary of the invention
The inventor has found the Chinese medicine medicine of effective treatment acne finally, thereby has accomplished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
The object of the invention just provides a kind of external used medicine that can effectively treat acne.
Another object of the present invention has just provided the method for preparing of this composition of medicine.
Medicine of the present invention selects for use Dianthus chinensis, Pelargonium, Ardisia mamillata, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, almond oil, Oleum Vitis viniferae to make up, and makes each efficacy of drugs produce synergism these drug regimens, thereby can treat acne fast, effectively removes comedo.Wherein select for use Dianthus chinensis to be because its nature and flavor are bitter, cold in nature, clearing away heat and promoting diuresis is arranged, promoting blood circulation to restore menstrual flow, repercussive function.Be used for urinary tract infection, blood stasis amenorrhea, carbuncle skin ulcer pain.Select for use Pelargonium to be because its nature and flavor are bitter, hot, property is flat, wind-damp dispelling is arranged, promoting blood circulation to restore menstrual flow network, heat-clearing and toxic substances removing, the function of antidiarrheal dysentery.Be used for rheumatic arthralgia, contracture is numb, carbuncle sore tumefacting virus, traumatic injury, enteritis and dysentery.Select for use Ardisia mamillata to be because its nature and flavor are bitter, cool in nature, clearing away heat-damp and promoting diuresis is arranged, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and hemostasis, the function of removing the necrotic tissue and promoting granulation.Be used for spitting blood, have blood in stool furuncle.Select for use the Herba Ocimi (Herba Ocimi Pilosi) quintessence oil to be because select for use the Herba Ocimi (Herba Ocimi Pilosi) quintessence oil to be because its main component is ocimene (Ocimene), australene (α-Pinene), 1; 8-cineole (1; 8-Cineole, Eucalyptole), labor Camphor tree alcohol (Linalool), Mang geraniol (Geraniol), limonene (Limonene), carene-3 "-f " flag ⊿ 3-Carene), estragole (Methylchavicol), eugenol (Eugenol), methyleugenol (Eugenol methyl ether), methoxybenzene (Anethole), methyl cinnamate (Methyl cinnaminate), hexene-3-ol-1 (3-Hexen-1-ol), octanone-3 (3-Octanone) and furfural (Furfural) etc., contain volatile oil 0.02-0.04%; The extraction of Herba Ocimi (Herba Ocimi Pilosi) quintessence oil is from blade and fresh idea; Be colourless quintessence oil, abnormal smells from the patient is refrigerant, and nervous system is had very strong stimulation; Use when tired and inspire enthusiasm immediately; Focus one's attention on, mouthfeel is fresh and sweet, has a little hot flavor.The Herba Ocimi (Herba Ocimi Pilosi) quintessence oil also has the improvement of tightening up and blocks skin, and the control acne are controlled head and migraine, flu, unusual, the myalgia of digestion; Can stimulate the estrogen secretion, be used for opsomenorrhea, prolonged not following; Also can be used for cough, rheumatism, puerpera's postpartum lactescence quantity not sufficient, carsickness is seasick etc.; It can treat various respiratory tract infection, also can alleviate stomach spasm or reduce dysmenorrhea.Dryness hydropenia or aging skin coarse, wrinkle there are the effect of moistening, also can be used for frequent overtime work and long-term black eye, eye pouch in the face of the computer appearance.The Herba Ocimi (Herba Ocimi Pilosi) quintessence oil has stronger medical value; Its nature and flavor are hot, warm, have relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness; The function of eliminating stasis to stop pain; Be used for anemofrigid cold, headache, pipe abdomen fullness, dyspepsia, stomachache, enteritis, diarrhea, treating swelling and pain by traumatic injury, rheumatic arthritis, external curing venom, eczema, dermatitis.Select for use almond oil to be because raw material Semen Armeniacae Amarum nature and flavor are bitter, temperature, poisonous.Go into lung, large intestine channel.Expelling phlegm for arresting cough is relievingd asthma, intestine moistening.Control the exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select for use Oleum Vitis viniferae to be because Semen Vitis viniferae contains Jiao's property catechol, Galla Turcica (Galla Helepensis) caffein, gallate etc.Have antiinflammatory, antimicrobial effect.Oleum Vitis viniferae contains linoleic acid and proanthocyanidin.Linoleic acid can be resisted free radical, and aging resistance helps to absorb vitamin C and E, strengthens the elasticity of blood circulation, reduces ultraviolet injury, and the collagen protein in the protection skin improves venous engorgement and edema, the prevention melanin deposition.Proanthocyanidin has the protection blood vessel elasticity, and the protection skin avoids ultraviolet afflicting with great suffering torment, and the destruction of prevention collagen fiber and elastic fiber makes skin keep due elasticity and tension force, avoids skin sagging and wrinkle to produce.Penetration is strong, and salubrious non-greasy is very easily by skin absorbs.
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range:
Dianthus chinensis 3-8 gram Pelargoniums 5-6 gram Ardisia mamillatas 3-6 grams
Herba Ocimi (Herba Ocimi Pilosi) quintessence oil 5-20 gram Oleum Vitis viniferaes 30-35 gram almond oil 20-25 grams
Preferable amount does
Dianthus chinensis 6 gram Pelargoniums 6 gram Ardisia mamillatas 5 grams
Herba Ocimi (Herba Ocimi Pilosi) quintessence oil 15 gram Oleum Vitis viniferaes 32 gram almond oil 24 grams
The method for preparing of medicine of the present invention is following
One, gets the raw materials ready
1, Dianthus chinensis: remove impurity;
2, Pelargonium: remove impurity, clean, dry;
3, Ardisia mamillata: remove impurity, dry;
4, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) stem leaves of plants, flower core herb, remove root, mud, rotted leaf, impurity, dry, extract quintessence oil;
5, almond oil: choose decontamination, put into oil press and squeeze almond oil;
6, Oleum Vitis viniferae: the Semen Vitis viniferae that will remove epidermis sarcocarp is chosen only and is dried, oil expression.
Two, preparation
1, with Dianthus chinensis, Pelargonium, the Ardisia mamillata decocte with water of said weight, add 4 times of amounts of water for the first time, soaks after 60 minutes, intense fire decocts boiling 10 minutes, the reuse slow fire boiling time decoction liquor of promptly winning in 20 minutes, will the first time decoction liquor pour in the container.Medicinal residues after filtering are for the first time added 2 times of amounts of water, boil with high heat earlier, reuse slow fire boiling 20 minutes, decoction liquor is poured in the container for the second time.Twice decoction liquor carried out mixing and stirring, and reuse slow fire boiling 20 minutes gets mixed liquor.
2, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) plant stem-leaf, pistil herb, remove root mud rotted leaf and impurity.With steeping 2-3h with the Alumen water logging in the exsiccant Herba Ocimi (Herba Ocimi Pilosi) input sedimentation tank, the weight ratio of water and Alumen is 1:0.0002.Put into boiler after cleaning with clean water, the addition of raw material is that boiler is volumetrical 80-90%, and amount of water was as the criterion to soak raw material, and fresh will distinguish steaming and decocting with exsiccant Herba Ocimi (Herba Ocimi Pilosi) plant.To heating at the bottom of the boiler; Carry out vapor distillation; The stirring impeller of opening simultaneously in the boiler overturns to raw material stirring, and along with increasing of temperature, the gooseneck conduit gets in the condenser respectively the Herba Ocimi (Herba Ocimi Pilosi) quintessence oil in the plant material through the pot top with the blended gas of water along with steam produces; Convert oil-water mixture to through condenser condenses and be disposed in the oil water separator, distillation time is 60-80 minutes.Collect the upper strata oil reservoir that oil water separator is separated, contain a spot of quintessence oil in the water of lower floor, be collected in the container back warp and cross repetition distillation extraction recovery quintessence oil wherein, pass through purification filtering again, promptly obtain pure natural Herba Ocimi (Herba Ocimi Pilosi) quintessence oil.
3, Semen Vitis viniferae, Semen Armeniacae Amarum are put into squeezer respectively, get its oil, get Oleum Vitis viniferae, almond oil respectively.
4, the mixed liquor that said medicine is extracted, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, Oleum Vitis viniferae, almond oil mix to stir processes ointment, is called for short sieve Portugal Fructus Pruni ointment.
Medicine of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and the function of removing the necrotic tissue and promoting granulation, in order to treatment acne instant effect, good effect, cure rate is high.
The specific embodiment
Below come further to set forth the beneficial effect of medicine according to the invention through Test Example, these Test Example have comprised the animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [Test Example 1] medicine of the present invention:
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg; Be pressed in the abdominal part that pulls out the clean rabbit hair and made film in 20 seconds with being immersed in cotton swab in the acetic acid, make the diameter 5-6mm of mucosa ulcer, divide two groups with rabbit after making film; Every group 15, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is every day 6 times, and normal amount is every day 2 times, and administering mode is the application administration, connects to apply 7 days, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [Test Example 2] Drug therapy burn of the present invention:
1, physical data
Accept out-patient's totally 422 examples for medical treatment, patients with mild 254 examples wherein, severe burn patient 168 examples.
2, diagnostic criteria
Patients with mild: be mainly pimple, pustule and blackhead.
Severe patient: skin lesion is a bunch collection property pimple, pustule, is maroon, and very fast downright bad, with blood crusts, outbreak forms netted cicatrix repeatedly.
3, Therapeutic Method
Select above-mentioned ointment for use, be applied to the affected part to the patient.Slight patients with acne is smeared 2 times every day, and early, respectively smear 1 time evening, 7 days is a course of treatment, continuously 2 courses of treatment of external application.Severe acne patient's external application every day 3 times, every day early, middle and late respectively smearing 1 time, 7 days is a course of treatment, continuously 4 courses of treatment of external application.During use, clean affected part, ointment is applied in affected part with warm water.
4, efficacy assessment standard
Produce effects: treatment back clinical symptom disappearance, it is normal that body constitution is recovered, and observes and do not have the recidivist half a year;
Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;
Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy fire victim's 422 examples of the present invention, its mild or moderate patients with acne 254 examples, produce effects 250 examples as a result, obvious effective rate is 98.43%, 4 examples that take a turn for the better, improvement rate is 1.57%, total effective rate is 100%.Severe acne patient's 168 examples, produce effects 156 examples as a result, obvious effective rate is 92.86%, 12 examples that take a turn for the better, improvement rate is 7.14%, total effective rate is 100%.
Claims (3)
1. sieve Portugal Fructus Pruni ointment of treating acne, it is characterized in that: it is to be processed by the crude drug in the following weight scope:
Dianthus chinensis 3-8 gram Pelargoniums 5-6 gram Ardisia mamillatas 3-6 grams
Herba Ocimi (Herba Ocimi Pilosi) quintessence oil 5-20 gram Oleum Vitis viniferaes 30-35 gram almond oil 20-25 grams.
2. according to sieve Portugal Fructus Pruni ointment of the said treatment acne of claim 1, it is characterized in that: wherein the consumption of each crude drug is:
Dianthus chinensis 6 gram Pelargoniums 6 gram Ardisia mamillatas 5 grams
Herba Ocimi (Herba Ocimi Pilosi) quintessence oil 15 gram Oleum Vitis viniferaes 32 gram almond oil 24 grams.
3. according to sieve Portugal Fructus Pruni ointment of claim 1 or 2 said treatment acnes, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Dianthus chinensis: remove impurity;
(2) Pelargonium: remove impurity, clean, dry;
(3) Ardisia mamillata: remove impurity, dry;
(4) Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) stem leaves of plants, flower core herb, remove root, mud, rotted leaf, impurity, dry, extract quintessence oil;
(5) almond oil: choose decontamination, put into oil press and squeeze almond oil;
(6) Oleum Vitis viniferae: the Semen Vitis viniferae that will remove epidermis sarcocarp is chosen only and is dried, oil expression;
(2) preparation
(1) with Dianthus chinensis, Pelargonium, the Ardisia mamillata decocte with water of said weight, add 4 times of amounts of water for the first time, soaks after 60 minutes, intense fire decocts boiling 10 minutes, the reuse slow fire boiling time decoction liquor of promptly winning in 20 minutes, will the first time decoction liquor pour in the container; Medicinal residues after filtering are for the first time added 2 times of amounts of water, boil with high heat earlier, reuse slow fire boiling 20 minutes, decoction liquor is poured in the container for the second time; Twice decoction liquor carried out mixing and stirring, and reuse slow fire boiling 20 minutes gets mixed liquor;
(2) Herba Ocimi (Herba Ocimi Pilosi) quintessence oil: get Herba Ocimi (Herba Ocimi Pilosi) plant stem-leaf, pistil herb, remove root mud rotted leaf and impurity, exsiccant Herba Ocimi (Herba Ocimi Pilosi) is dropped in the sedimentation tank with Alumen water logging bubble 2-3h; The weight ratio of water and Alumen is 1:0.0002, puts into boiler after cleaning with clean water, and the addition of raw material is a boiler volumetrical 80-90%; Amount of water was as the criterion to soak raw material, and fresh will distinguish steaming and decocting with exsiccant Herba Ocimi (Herba Ocimi Pilosi) plant, to heating at the bottom of the boiler; Carry out vapor distillation, the stirring impeller of opening simultaneously in the boiler overturns to raw material stirring, along with increasing of temperature; The gooseneck conduit gets in the condenser respectively Herba Ocimi (Herba Ocimi Pilosi) quintessence oil in the plant material through the pot top with the blended gas of water along with steam produces; Convert oil-water mixture to through condenser condenses and be disposed in the oil water separator, distillation time is 60-80 minutes, collects the upper strata oil reservoir that oil water separator is separated; Contain a spot of quintessence oil in the water of lower floor; Be collected in the container back warp and cross repetition distillation extraction recovery quintessence oil wherein, pass through purification filtering again, promptly obtain pure natural Herba Ocimi (Herba Ocimi Pilosi) quintessence oil;
(3) Semen Vitis viniferae, Semen Armeniacae Amarum are put into squeezer respectively, get its oil, get Oleum Vitis viniferae, almond oil respectively;
(4) mixed liquor that said medicine is extracted, Herba Ocimi (Herba Ocimi Pilosi) quintessence oil, Oleum Vitis viniferae, almond oil mix to stir processes sieve Portugal Fructus Pruni ointment.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210279477.9A CN102764344B (en) | 2012-08-08 | 2012-08-08 | Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof |
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| CN201210279477.9A CN102764344B (en) | 2012-08-08 | 2012-08-08 | Ointment containing basil essential oil, almond oil and grape seed oil for treating acne and preparation method thereof |
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| CN102764344B CN102764344B (en) | 2014-02-12 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178237A (en) * | 2011-04-28 | 2011-09-14 | 永登苦水兴顺玫瑰花有限公司 | Kushui rose oil soft capsules |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178237A (en) * | 2011-04-28 | 2011-09-14 | 永登苦水兴顺玫瑰花有限公司 | Kushui rose oil soft capsules |
Non-Patent Citations (6)
| Title |
|---|
| 《中医药导报》 20100131 顾严严等 浅析痤疮古今用方之配伍规律 78-80 1-3 第16卷, 第1期 * |
| 《中国化妆品（行业版）》 20020630 李宏 芳香疗法三则 74-86 1-3 , 第6期 * |
| 《国际中医中药杂志》 20060131 吴小红等 用于化妆品中的植物 51-54 1-3 第28卷, 第1期 * |
| 吴小红等: "用于化妆品中的植物", 《国际中医中药杂志》 * |
| 李宏: "芳香疗法三则", 《中国化妆品（行业版）》 * |
| 顾严严等: "浅析痤疮古今用方之配伍规律", 《中医药导报》 * |
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