CN108852865A - A kind of fullerene topical composition - Google Patents
A kind of fullerene topical composition Download PDFInfo
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- CN108852865A CN108852865A CN201810777244.9A CN201810777244A CN108852865A CN 108852865 A CN108852865 A CN 108852865A CN 201810777244 A CN201810777244 A CN 201810777244A CN 108852865 A CN108852865 A CN 108852865A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
The invention discloses oil-soluble fullerene topical composition and its preparation method and application, its fullerene for containing oil solubility aids and dissolving in oil solubility aids of oil-soluble fullerene topical composition, the composition has the effect of beauty.
Description
Technical field
The present invention relates to a kind of daily chemicals field, in particular to a kind of topical composition with beautification function.
Background technique
Scientist Kroto, Smalley, Curl in 1985 et al. have found C60 richness when studying the carbon of space depths
Alkene is strangled, therefore three people obtain Nobel chemistry Prize within 1996.Fullerene and diamond, graphite are all the allotrope of carbon.
The global molecular that C60 is made of 60 carbon atoms, by 12 pentagons and 20 hexagonal groups at, each carbon atom and adjacent
Three carbon atoms pass through SP2Hydridization bonding, because being similar to football due to referred to as CITE.What it is with caged Carbon Cluster structure is
Column molecule is collectively referred to as molecule and has been collectively referred to as cage Note><Cite><Au ene derivative and heterocycle fullerene etc..Common C60,
The types such as C70, C76, C84.
The big pi bond conjugated system that multiple P tracks of fullerene are constituted, so that it connects nucleophobic ability with stronger,
Because of its unique structure and physicochemical property, excellent removing free radical performance, referred to as " free radical sponge " are made it have, simultaneously
Also show excellent antioxygenic property.Make its cosmetic material, in terms of obtain extensive concern.
By the way that C60 to be embedded in surfactant, C60 can still eliminate intracellular active oxygen, inhibit going for mitochondria
Polarization, the activation of cysteine proteinase, the exposure of phosphatidylserine and the division of DNA on cell membrane, C60 are shown
Protect the effect of the not oxidized apoptosis of cell.C60 liposome complex is by defence UVA to skin texture, nucleus and collagen
The destruction of fiber and antioxidation is played to the infiltration of human skin tissue, is 172 times of Vitamin C, it can be affine
Free radical.
Fathi Moussa teach long campaigns C60 property research work, as by fullerene be dissolved in olive oil into
Row research it is the first, they by feeding primary (per kilogram of body weight feeds 4 milligrams of fullerenes) every two weeks to mouse 10-17 months,
The 17-38 month death of control group mouse, and the test group service life then extends to 59-66 months, discovery fullerene has long-life health care
Function.Period no matter weight, none exception of physiological performance finds that C60 has toxicity and biological heredity, opposite a certain amount of
C60 have remove free radical performance, thus make animal from cross polyradical generate harm.
As exterior-applied article, have the patent report relevant product of fullerene, such as C60-PVP, application number：
200480005008.1,200580049615.2, since preparation process and the composite attribute of PVP and C60 limit, in the compound
In, the content of C60 is no more than 1%, and PVP has apparent film forming in addition, and excessive is coated in after skin surface to certain makeups
The performance of product effect can play certain inhibition.C60- saualane, application number 201510427642.4, but C60 is at angle
Solubility in shark alkane is limited, while saualane is oil solution, so that the use of the series of products is limited.Fullerene nanoparticle suspension
Liquid CN201510971343.7, but the ingredient is the fullerene ingredient of bulky grain, and it is steady to will affect formula after being added in formula
Qualitative and appearance and usage comfort, and the fullerene ingredient of bulky grain is difficult to play repair in skin, is only capable of adhering to
In skin surface, barrier action is played.
Fullerene is a kind of nonpolar molecule, has strong hydrophobicity, can only be dissolved in non-pole harmful to organism
Property organic solvent such as toluene, benzene, hexamethylene, in chloroform.Fullerene hydrophobic nature itself directly affects its bioactivity
It plays, in order to preferably promote to absorb, fullerene is made and is easy to the solution-type that skin quickly absorbs its molecular state, it will be rich
The ingredient for strangling the alkene compounding close and friendly type of skin is investigated not yet.
The composition containing fullerene of the invention patent invention, it is ensured that fullerene is scattered in selected solvent with molecular state
In, the obtained composition property containing fullerene is stablized, and can be used for any external prescription.Fullerene is in composition of the invention
Dissolved state can preferably act on skin as externally applied product ingredient.
Summary of the invention
The purpose of the present invention is to provide a kind of fowler ene compositions, dissolved state is presented in fullerene in the composition, and
It quickly absorbs, there is whitening spot-removing, anti-wrinkle, anti-acne, the effect of anticreep strengthen the hair.
On the one hand, the present invention provides a kind of fowler ene compositions, help containing oil solubility aids and in oil-soluble
The fullerene for dissolving or dispersing in agent.
On the one hand, the present invention provides a kind of fullerene dispersion, the system contains fullerene and oil-soluble helps
Agent, it is characterised in that 50% or more in the dispersion, such as 60%, 70%, 80%, 90%, 95%, 99% or more grain
Diameter is less than 5nm.
On the one hand, the present invention provides the preparation method of a kind of fowler ene compositions or dispersion, feature exists
In including the following steps：Fullerene powder is taken, oil solubility aids are put into high pressure homogenizer, 50- after mixing
500MPa, preferably 100-300MPa, further preferred 200MPa homogeneous 1-10 times, preferably 3-8 times, further preferred 5 times, then
Temperature of charge is controlled at 0-25 DEG C, preferably 5-20 DEG C, further preferred 10-15 DEG C, 1-20h, preferably 5-15h is stirred, into one
Preferred 12h is walked, product is then centrifuged for and/or is obtained by filtration.
On the one hand, the present invention provides the fowler ene compositions or dispersion that use method of the invention to prepare.
According to any preceding aspect, the present invention provides a kind of fowler ene compositions, which is characterized in that in addition to oil-soluble helps
Except agent and fullerene, also containing at least one antioxidant.
According to any preceding aspect, the present invention provides a kind of fowler ene compositions, which is characterized in that in addition to oil-soluble helps
Except agent and fullerene, also contain at least one other active constituent.
According to any preceding aspect, the present invention provides a kind of fowler ene compositions answering in preparation beauty or cosmetic product
With.
According to any preceding aspect, the present invention provides a kind of fowler ene compositions in preparation for beauty or cosmetic use
Application in instrument.
According to any preceding aspect, the present invention provides a kind of method of beauty, and the method includes having to subject's application
The composition of the invention of effect amount or medicament comprising the present composition, optionally, the cosmetic result includes whitening spot-removing,
Anti-wrinkle, anti-acne, at least one of anticreep strengthen the hair.
According to any preceding aspect, the present composition can also be used together with other auxiliary materials.
According to any preceding aspect, the present composition can be used together with surfactant.
According to any preceding aspect, the present composition be introduced into cosmetics or drug delivery system and/or delay
In release system.
According to any preceding aspect, the oil solubility aids are selected from：Jojoba Oil, sad certain herbaceous plants with big flowers acid glycerol three ester, palmitinic acid
At least one of different monooctyl ester, isopropyl palmitate, myristyl myristate, it is preferable that the oil solubility aids are lotus lotus
At least one of bar oil, sad certain herbaceous plants with big flowers acid glycerol three ester, isobutyl palmitate.
According to any preceding aspect, the fullerene is empty fullerene, metal fullerene, heterocycle fullerene and embedded richness
Strangle one or more of alkene.Including but not limited to fullerene C2n、M@C2n、M2@C2n、MA@C2n、M3N@C2n、M2C2@C2n、M2S@
C2n、M2O@C2nAnd MxA3-xN@C2nAny one of, wherein M and A is metallic element, and the M and A are selected from Sc, Y and group of the lanthanides
Any one in metallic element；30≤n≤60；0≤x≤3, it is preferable that the fullerene is C60, C70, C76, C84, Gd@
In C82 and its derivative any one or mixtures thereof, it is further preferred that the fullerene is C60.
The present composition for example can be oily suspensions, solution as the form of liquid preparation, can also be one
Kind can use water or the dry products of other suitable carrier compoundings before use.This liquid preparation contains conventional addition
Agent, such as suspending agent, such as sorbierite, methylcellulose, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminum stearate are solidifying
Glue or hydrogenated edible fats；The preparation of solution is usually and to be filled by the way that active material to be dissolved in a kind of carrier
Disinfection is filtered before entering a kind of suitable bottle or ampoule, is then sealed.
On the one hand, the present invention provides a kind of fowler ene compositions and prepares aqua method：By fowler ene compositions according to than
It after example is mixed with water, stirs evenly, then homogeneous is good, and preservative is added and essence obtains aqua.
The form of emulsion is made in the present composition, may include conventional emulsifier, helps emulsion, surfactant etc..
On the one hand, the present invention provides a kind of fowler ene compositions preparation emulsion methods：By fowler ene compositions according to than
Example is mixed with emulsifier, then carries out homogeneous, at emulsion or lotion, preservative is added and essence obtains emulsion.
On the one hand, the present invention provides the use of composition or dispersion of the invention in preparation beauty or cosmetic product
On the way.
On the one hand, the present invention provides the instrument of composition or dispersion of the invention in preparation for beauty or makeup
In purposes.
According to any preceding aspect, the beauty or cosmetic product are used for whitening spot-removing, anti-wrinkle, anti-acne, anti-haze, and hair tonic is solid
Hair etc..
Detailed description of the invention
Fig. 1：Electron microscope experiment result.
Fig. 2：Anti-acne experiment.
Fig. 3：Anti-acne tests quantitative result.
Fig. 4：Whitening experimental result.
Fig. 5：Anti- haze experimental result.
Specific embodiment
With reference to the accompanying drawing, specific embodiments of the present invention will be described in detail, it is to be understood that guarantor of the invention
Shield range is not limited by the specific implementation.
Unless otherwise explicitly stated, otherwise in entire disclosure and claims, term " includes " or its change
Changing such as "comprising" or " including " etc. will be understood to comprise stated element or component, and not exclude other members
Part or other component parts.
In one embodiment, the present invention provides a kind of fowler ene compositions, containing oil solubility aids and
The fullerene for dissolving or dispersing in oil solubility aids, optionally, the fullerene concentration are 0.01-5mg/ml, preferably 0.05-
3mg/ml, more preferable 0.1-2mg/ml, further preferred 1mg/ml.
In one embodiment, the present invention provides a kind of fullerene dispersion, the system contain fullerene and
Oil solubility aids, it is characterised in that 50% or more in the dispersion, such as 60%, 70%, 80%, 90%, 95%, 99%
Above partial size is less than 5nm.
In one embodiment, the present invention provides the preparation method of a kind of fowler ene compositions or dispersion,
It is characterised in that it includes following steps：Fullerene powder is taken, oil solubility aids are put into high pressure homogenizer after mixing,
50-500MPa, preferably 100-300MPa, further preferred 200MPa homogeneous 1-10 times, preferably 3-8 times, further preferred 5 times,
Then temperature of charge is controlled at 0-25 DEG C, preferably 5-20 DEG C, further preferred 10-15 DEG C, stirs 1-20h, preferably 5-15h,
Further preferred 12h is then centrifuged for and/or is obtained by filtration product.
In one embodiment, the present invention provides a kind of fowler ene compositions, which is characterized in that in addition to oil-soluble helps
Except agent and fullerene, also containing at least one antioxidant, the antioxidant be selected from superoxide dismutase, mannitol,
Histidine, tryptophan, bilirubin, Quercetin, quercitin, polyphenol, procyanidine, tocotrienols, catechuic acid, catechuic acid spread out
Biology, rutin and its derivative, gallic acid and its derivative, ubiquinone, astaxanthin, carrotene and other carotenoids
Salt, vitamine B group and its derivative and their salt, vitamin D class and its derivative of plain substance and its derivative and they
In object and their salt, vitamin E class and its derivative and their salt, dibutyl hydroxy toluene and butylated hydroxyanisole (BHA)
At least one.
In one embodiment, the present invention provides a kind of fowler ene compositions, which is characterized in that in addition to oil-soluble helps
Except agent and fullerene, also contain at least one other active constituent, the active constituent includes but is not limited to：Matrix metal
Elastatinal, melanin genesis stimulant or inhibitor, brightening agent or decolorising agent, chromogen forming agent, self-tanning agent resist
Aging agent, NO- synthase inhibitor, antioxidant, free radical scavenger and/or anti-atmosphere pollution agent, anti-saccharifying agent, emulsifier,
Emollient, organic solvent, liquid propellant, skin conditioner such as wetting agent, retain the substance of moisture, alpha-hydroxy acid, beta hydroxy acid,
Moisturizer, epidermis hydrolase, vitamin, pigment or colorant, dyestuff, gelatin polymer, intensifier, surfactant, softening
Agent, anti wrinkling agent can reduce or treat the medicament of eye pouch, exfoliator, antimicrobial, fungicide, fungistat, kill thin
Microbial inoculum, presses down bacteriocin, corium or epidermal macromolecules synthesizes stimulant and/or can prevent or inhibit corium or epidermal macromolecules from dropping
The medicament of solution, collagen synthesis stimulant, elastin laminin synthesizes stimulant, decorin synthesizes stimulant, layer adhesion
Albumen synthesizes stimulant, alexin synthesizes stimulant, molecular chaperones synthesizes stimulant, aquaporin synthesizes stimulant are transparent
The component synthesizes stimulant of matter acid synthesizes stimulant, lipid and cuticula, ceramide synthesizes stimulant, collagen degradation suppression
Preparation, elastin degradation inhibitor, fibroblast proliferation stimulant, keratinocyte proliferation stimulant, fat cell
It is proliferated stimulant, melanocyte proliferation stimulant, Keratinocyte differentiation stimulant, Adipocyte Differentiation stimulant, acetyl
Anticholinesterase, skin relaxant, glycosaminoglycan synthesizes stimulant, DNA renovation agent, DNA protective agent, antipruritic are used for
The medicament for the treatment of and/or nursing sensitive skin, curing agent, anti-vergeture agent, astringent adjust the medicament that sebum generates, fat
Stimulant is decomposed, anti-cellulite tissue inflammation agent, heal stimulant, and healing auxiliary adjuvant, epithelium re-forms stimulant, and epithelium re-forms
Auxiliary adjuvant, cytokine growth factor, sedative, anti-inflammatory agent act on the medicament of capillary circulation and/or microcirculation, blood
Pipe generates stimulant, and vasopermeability inhibitor acts on the medicament of cell metabolism, for improving the medicine of dermal-epidermal engagement
Agent, trichogenous medicament restrain or delay the medicament of hair growth, preservative, aromatic, chelating agent, plant extract
Object, essential oil, marine extracts, the medicament from biological fermentation process, mineral salt, cell extract and opacifier are (for ultraviolet
Or mixtures thereof organic or mineral the bright protective agent that line A and/or Ultraviolet B work),.
In one embodiment, the present invention provides a kind of fowler ene compositions answering in preparation beauty or cosmetic product
With.
In one embodiment, the beauty or cosmetic product dosage form include but is not limited to solution, suspension, milkiness
Liquid, paste, gelling agent, creme, lotion, pulvis, soap, the detergent containing surfactant, oil, powder cream base, lotion, foundation cream
Any dosage form in frost, cerul vanishing cream, spray, liniment, paste and opoultice, such as cream, multiple emulsion, anhydrous compositions
Object, water dispersant, oil, lotion, face cream, foam, washing lotion, gel, cream-gel, water-alcohol solution, water glycol solution, liniment, salt
Aqueous solution, soap, shampoo, regulator, slurries, ointment, mousse, ointment, pulvis, stylus, pencil, spray, aerosol,
Capsule, gelatine capsule, tablet, sugar coated tablet, pulvis, particle form, chewing gum, solution, suspension, emulsion, syrup, polysaccharide
Film, frozen glue, gelatin, ointment, creme, soft toner, nutrition toner, facial mask, essence, hair restorer, shampoo, rinsing
Agent, hair conditioner, hair-care agent, gelling agent, skin lotion, skin softener, toner, astringent, lotion, milky lotion,
Moisturizing emulsion, nutritional emulsions, massage cream, nourishing cream, moisturiser, hand lotion, vanishing cream, nutrition essence, suncream, soap, cleaning
Foam, cleanser, cleansing cream, body lotion and clean body agent, eye pouch remover, cosmetic foundation, makeup removing washing lotion, makeup removing breast
Liquid, eye shadow, lipstick, lip gloss and lip powder；The effect of beauty or cosmetic product includes but is not limited to：Skin whitening improves color
Element precipitating, treatment acne improve wrinkle, improve pachylosis, improve Oily, improve dry skin, pore refining, treatment
Scar, treatment flushed face, hair growth, promote hair tonic, treatment burn, skin sterilization, skin mite killing, improvement skin pit,
At least one of anti-acne, anti-haze.
In one embodiment, the present invention provides a kind of fowler ene compositions in preparation for beauty or cosmetic use
Application in instrument, the instrument include but is not limited to disinfection pad, disinfecting cotton stick, sterile package, medical dressing wet tissue, nursing
Liquid, cleaning solution, dressing, liquid dressing, adhesive bandage；The application can be the present composition and be attached on certain material, institute
Stating material includes but is not limited to：Cotton swab, wet tissue, towel, paper handkerchief, gauze, swab stick, non-woven fabrics, high molecular material, medical dressing,
The non-sticky gauze of plastic pattern, petrolatum oil gauze, semipermeable film, spumescence auxiliary material etc..
In one embodiment, the present composition can also be used together with other auxiliary materials, and the auxiliary material includes saturating
Bright matter acid, grease type, surfactant, preservative, fragrance, adhesive, thickener, complexing agent, PH regulator.
In one embodiment, the present composition can be used together with surfactant, the surfactant
It is selected from：Anionic surfactant, cationic surfactant, amphoteric surfactant, lipophilic nonionic surfactant,
Hydrophilic non-ionic surfactant is naturally at least one of surfactant.
In one embodiment, as anionic surfactant, for example, can enumerate soap raw material, sodium laurate,
The fatty acid soaps such as sodium palmitate, the high alkyl sulfates salt such as NaLS, lauryl potassium sulfate, polyoxyethylene (POE)-
The alkyl ether sulphate salts such as triethanolamine lauryl sulfate, POE- NaLS, the N- acyl group flesh such as sodium lauroyl sarcosine
Propylhomoserin, N- myristoyl-N methyl taurine sodium, coconut oil fat acid methyl taurine sodium, lauryl methyl sodium taurocholate
Etc. advanced fatty acid amide sulfonate, the phosphate ester salts such as POE- oleyl ether phosphoric acid sodium, POE- stearoyl ether phosphoric acid, two -2- second
Base hexyl sodium sulfosuccinate, single lauroyl single ethanol amide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulphur
The sulfosuccinates such as base sodium succinate, linear alkyl benzene sulphonate, linear dodecylbenzene sulfonic acid triethanolamine, straight chain
The alkylbenzene sulfonates such as dodecyl benzene sulfonic acid, N- lauroyl glutamate list sodium, N- stearyl disodium glutamate, N- Pork and beans
The N- acyl glutamates such as cool acyl group-Pidolidone list sodium, the high-grade aliphatic esters such as hardening coconut oil fat acid glycerol sodium sulphate
Sulfuric acid, the sulfated oils such as turkey red oil, POE- alkyl ether carboxylic acid, POE- polyoxyethylene base ether carboxylate, alpha-olefin sulphur
Hydrochlorate, higher fatty acids sulfonated ester, secondary alcohol sulphates salt, higher aliphatic acid alkylolamide sulfuric acid, lauroyl list second
At least one of alkylolamides sodium succinate, two triethanolamine of N- palmityl aspartic acid and casein-sodium etc..
In one embodiment, as cationic surfactant, for example, can enumerate stearyl trimethyl ammonium chloride,
The alkyl trimethyl ammonium salts such as lauryl trimethyl ammonium chloride, VARISOFT TA100 dialkyl dimethyl ammonium salt, chlorination
The Fixanols such as poly- (N, N '-dimethyl -3,5- methylenepiperidines), cetylpyridinium chloride, alkyl quaternary ammonium salts, alkane
Base dimethyl benzyl ammonium salt, alkyl isoquinolinium salt, dialkylmorpholinum salts, POE- alkylamine, alkylamine salt, polyamine fatty acid
At least one of derivative, amylalcohol derivative of fatty acid, benzalkonium chloride and benzethonium chloride etc..
In one embodiment, as amphoteric surfactant, such as 2- undecyl-N, N, N- (hydroxyl can be enumerated
Ethyl carboxymethyl) the imidazolines system two such as -2- imidazoline sodium, 2- cocoyl -2- imidazoline hydroxide -1- carboxylic ethyoxyl disodium salt
Property surfactant, 2- heptadecyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaine, lauryl dimethyl amion acetic acid
In the glycine betaines such as glycine betaine, alkyl betaine, amido betaine and sulfobetaines system amphoteric surfactant etc. extremely
Few one kind.
In one embodiment, as lipophilic nonionic surfactant, such as sorbitan can be enumerated
Monoleate, sorbitan list isostearate, sorbitan monolaurate, sorbitan list palmitinic acid
Ester, sorbitan monostearate, NOFABLE SO-992, sorbitan trioleate, five -2- second
The Sorbitans alcohol esters such as two dehydrating glycerin sorbitol ester of base caproic acid, four -2 ethyl hexanoic acids, two dehydrating glycerin sorbitol ester
Fat esters of gallic acid, single cottonseed oil fatty acid glyceride, single erucic acid glyceride, sesquialter olein, glycerin monostearate, α,
The fatty acid glycerines esters such as α '-oleic acid pyroglutamic acid glyceride, glycerin monostearate, it is single two glyceride of isostearic acid, two different
The polyglyceryl fatty acid esters such as two glyceride of stearic acid, the methyl glycol fatty acid esters such as propylene glycolmonostearate class, hardened castor oil
At least one of derivative and glycerol alkyl ether etc..
In one embodiment, as hydrophilic non-ionic surfactant, such as POE- anhydrosorbitol can be enumerated
Sorbitane monooleate, POE- sorbitan monostearate, POE- dehydrated sorbitol mono-fatty acid ester, POE- anhydrosorbitol
The POE- sorbitan fatty acid esters class such as four oleate of sugar alcohol, POE- D-sorbite monolaurate, POE- D-sorbite
The POE- sorbitan fatty acid esters such as monoleate, five oleate of POE- D-sorbite, POE- sorbitan monostearate,
The POE- glycerine fatty acids such as POE- glyceryl monostearate, POE- glycerol monoisostearate, POE- glyceryl triisostearate
Esters, the POE- fatty acid such as POE- monoleate, POE- distearate, the mono- dioleate of POE-, diglycol stearate
Esters, POE- lauryl ether, POE- oleyl ether, POE- stearoyl ether, POE- Shan Yu acyl ether, POE-2- octyldodecyl
The POE- alkyl ethers such as ether, POE- cholestane alcohol ether, Pluronic (addition polymers of polypropylene glycol and ethylene oxide) etc.
Pluronic type class, POEPOP- cetyl ether, POEPOP-2- decyl four last of the ten Heavenly stems ether, POEPOP- monobutyl ether, POEPOP-
The POEPOP- alkyl ethers such as hydrogenated lanolin, POEPOP- glycerin ether, POE- castor oil, POE- hardened castor oil, POE-
Hardened castor oil list isostearate, three isostearate of POE- hardened castor oil, POE- hardened castor oil list pyroglutamic acid list
The POE- castor oil hardened castor oil derivatives such as isostearic acid diester, POE- hardened castor oil maleic acid, POE- D-sorbite bee
The POE- beeswax lanolin derivative such as wax, cocoanut fatty acid diethanolamide, lauric monoethanolamide, fatty acid isopropyl
The alkanolamides such as alkylolamides, POE- methyl glycol fatty acid ester, POE- alkylamine, POE- fatty acid amide, sucrose fatty ester,
At least one of POE- nonyl phenyl formaldehyde condensation products, alkyl ethoxy dimethyl amine and three oleyl phosphoric acid etc..
In one embodiment, as being naturally surfactant, such as soybean lecithin, hydrogenated soybean phosphorus can be enumerated
At least one of the lecithins lipids or soybean Escin etc. such as rouge, lecithin, hydrogenation lecithin.
In one embodiment, the present composition be introduced into cosmetics or drug delivery system and/or delay
In release system, the cosmetics or drug delivery system and/or slow-released system are selected from the group being made up of：Liposome, mixing
Liposome, millimeter microcapsules, microcapsules, capsule of nano, sponge, cyclodextrin, vesica, micella, surfactant mixed micelle,
Phosphatide-surfactant mixed micelle, millimeter microballoon, microballoon, nanosphere, lipid microspheres, microemulsion, nanoemulsion, millimeter are micro-
Grain, particle, nanoparticle and solid lipid nano particle.
In one embodiment, the oiliness auxiliary agent can be selected from liquid fat, solid grease, wax class, hydrocarbon ils, advanced
At least one of fatty acid, higher alcohol, ester oil, silicone oil.
In one embodiment, as liquid fat, such as avocado oil, camellia oil, turtle oil, Queensland nut can be enumerated
Oil, corn oil, sunflower oil, ermine oil, olive oil, rapeseed oil, egg oil, sesame oil, apricot kernel oil, wheat-germ oil, camellia
Oil, castor oil, Linseed oil, safflower oil, grape seed oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea-seed oil, coconut
Oil, rice bran oil, paulownia oil, Japanese tung oil, Jojoba Oil, embryo oil, evening primrose oil, tricaprylin and three different palmitinic acids
At least one of glyceride etc..In addition, liquid fat here refers to the grease for liquid at room temperature.
In one embodiment, as solid grease, such as cocoa butter, coconut oil, tallow, suet, horse can be enumerated
Rouge, lard, ox bone rouge, vegetable wax oil, ox foot rouge, vegetable wax, hardening coconut oil, hardened palm oil, hardens tallow, is hard at palm-kernel oil
At least one of carburetion and hardened castor oil etc..
In one embodiment, as wax class, such as beeswax, candelila wax, cotton wax, palm wax, red bayberry can be enumerated
Wax, insect wax, spermaceti, lignite wax, rice bran wax, kapok wax, sugarcane wax, lanolin, acetic acid lanolin, liquid lanolin, lanolin
Isopropyl fatty acid ester, reduction lanolin, hard lanolin, lauric acid hexyl ester, He Heba wax, shellac wax, POE lanolin alcohol ether,
In POE lanolin alcohol acetic acid esters, POE cholesterol ethers, lanolin fatty acid polyethylene glycol and POE hydrogenated lanolin alcohol ether etc.
It is at least one.
In one embodiment, as hydrocarbon ils, such as the different stone of atoleine, isoparaffin, heavy liquid can be enumerated
Wax hydrocarbon, paraffin hydrocarbon, ceresine, saualane, vegetalitas saualane, pristane, ceresin, squalene, vaseline, microwax, paraffin,
At least one of lignite wax, olefin oligomer, polyisobutene, polybutene and hydrogenated polybutene etc..
In one embodiment, as higher fatty acids, such as lauric acid, myristic acid, palmitinic acid, hard can be enumerated
Resin acid, behenic acid (Behenicacid), oleic acid, undecenoic acid, talloleic acid, isostearic acid, linoleic acid, linolenic acid, 20
At least one of carbon 5 alkene acid (EPA) and docosahexaenoic acid (DHA) etc..
In one embodiment, as higher alcohol, for example, can enumerate laruyl alcohol, cetanol, stearyl alcohol, behenyl alcohol,
The straight chain alcohols such as myristyl alcohol, oleyl alcohol, 16 stearyl alcohols, single stearyl glycerin ether (batyl alcohol), 2- decyl alkanol, lanolin
At least one in branched-chain alcohos such as alcohol, cholesterol, phytosterol, hexyl dodecanol, isooctadecanol and octyldodecanol etc.
Kind.
In one embodiment, as ester oil, such as isopropyl myristate, isooctyl acid cetyl, meat can be enumerated
Myristic acid octyldodecyl ester, isopropyl palmitate, isobutyl palmitate, butyl stearate, lauric acid hexyl ester, myristic acid meat
Cardamom ester, decyl oleate, sad certain herbaceous plants with big flowers acid glycerol three ester, dimethyl-octyl hexyl decyl ester, cetyl lactate, Tetradecyl lactate,
Lactic acid octyldodecyl ester, acetic acid lanolin, Standamul 7061, the different cetyl of isostearic acid, 12- hydroxy stearic acid gallbladder are solid
Alcohol ester, 12- hydroxy stearic acid phytosterin ester, oleic acid phytosterin ester, two -2 ethyl hexanoic acid glycol esters, two capric acid the third two
Alcohol ester, dipentaerythritol aliphatic ester, single isostearic acid N- alkyl diol ester, two capric acid neopentyl glycol ester, malic acid two are different hard
Rouge ester, two -2- heptylundecanoic acid glycerides, trimethylolpropane tris -2 ethyl hexanoic acid ester, the different tristearin of trimethylolpropane tris
Acid esters, four -2 ethyl hexanoic acid pentaerythritol esters, three -2 ethyl hexanoic acid glyceride, three (capryl capric acid) glyceride, the three (last of the ten Heavenly stems
Acyl group decanoin myristin stearic acid) glyceride, trimethylolpropane tris isostearate,
2 ethyl hexanoic acid cetyl, palmitinic acid 2- ethylhexyl, myristin, three -2- heptylundecanoic acid glycerides, two
Isostearic acid polyglycerol ester, three isostearic acid polyglycerol esters, four isostearic acid polyglycerol esters, three isostearic acids, two glyceride, four
Two glyceride of isostearic acid, three 2 ethyl hexanoic acid erythrite esters, two trimethylolpropane tris -2 ethyl hexanoic acid ester, (different tristearin
Acid/decanedioic acid) two trimethylolpropane oligoesters, Castor Oil Fatty Acid methyl esters, oleic acid oleic alcohol ester, acetoglyceride, palmitinic acid
2- heptylundecanoic ester, diisobutyl adipate, (adipic acid 2 ethyl hexanoic acid stearic acid) glycerol oligoester, (2- hexyl
Capric acid decanedioic acid) two glyceride oligoesters, N- lauroyl-Pidolidone -2- octyldodecyl ester, two -2- heptan of adipic acid
Base hendecane ester, ethyl laurate, Diisooctyl Sebacate, myristic acid 2- hexyl last of the ten Heavenly stems ester, the palmitinic acid 2- hexyl last of the ten Heavenly stems
Ester, adipic acid 2- hexyl last of the ten Heavenly stems ester, diisopropyl sebacate, succinic acid 2- ethylhexyl, ethyl acetate, butyl acetate and lemon
At least one of triethylenetetraminehexaacetic acid ester etc..
In one embodiment, as silicone oil, such as the poly- silicon oxygen of dimethyl polysiloxane, aminomethyl phenyl can be enumerated
The chains such as alkane, methylhydrogenpolysi,oxane polysiloxanes, octamethylcy-clotetrasiloxane, decamethylcyclopentaandoxane, ten diformazan basic rings
In the cyclic polysiloxanes and polyoxyethylene polyalkylsiloxane etc. such as six siloxanes, tetrahydro tetramethyl-ring tetrasiloxane at least
It is a kind of.
In one embodiment, the oil solubility aids are selected from：Jojoba Oil, sad certain herbaceous plants with big flowers acid glycerol three ester, palmitinic acid
At least one of different monooctyl ester, isopropyl palmitate, myristyl myristate, it is preferable that the oil solubility aids are lotus lotus
At least one of bar oil, sad certain herbaceous plants with big flowers acid glycerol three ester, isobutyl palmitate.
In one embodiment, SIMMONDSIA CHINENSIS SEED OIL, sad certain herbaceous plants with big flowers acid glycerol three ester, palmitinic acid are different pungent in the oil solubility aids
Ester, quality proportioning are (1-7)：(1-7)：(1-7), for example, 7：2:1,5:4:1,3:6:1,6:1:3,4:1:5,2:1:7 preferably
It is 4：1：5.
In one embodiment, the fullerene is empty fullerene, metal fullerene, heterocycle fullerene and embedded richness
Strangle one or more of alkene.Including but not limited to fullerene C2n、M@C2n、M2@C2n、MA@C2n、M3N@C2n、M2C2@C2n、M2S@
C2n、M2O@C2nAnd MxA3-xN@C2nAny one of, wherein M and A is metallic element, and the M and A are selected from Sc, Y and group of the lanthanides
Any one in metallic element；30≤n≤60；0≤x≤3, it is preferable that the fullerene is C60, C70, C76, C84, Gd@
In C82 and its derivative any one or mixtures thereof, it is further preferred that the fullerene is C60.
In one embodiment, the present composition as the form of liquid preparation for example can be oily suspensions,
Solution, can also be a kind of can use water or the dry products of other suitable carrier compoundings before use.This liquid preparation
Containing conventional additive, such as suspending agent, such as sorbierite, methylcellulose, gelatin, hydroxyethyl cellulose, carboxymethyl
Cellulose, aluminium stearate gel or hydrogenated edible fats；The preparation of solution is usually by the way that active material is dissolved in one kind
In carrier, and disinfection is filtered before being loaded into a kind of suitable bottle or ampoule, then seal.
In one embodiment, the present invention provides a kind of fowler ene compositions to prepare aqua method：It will be of the invention
It after fowler ene compositions are proportionally mixed with water, stirs evenly, then homogeneous is good, and preservative is added and essence obtains aqua.
In one embodiment, the form of emulsion is made in the present composition, may include conventional emulsifier, helps cream
Agent, surfactant etc..
In one embodiment, the present invention provides a kind of fowler ene compositions to prepare emulsion methods：It will be of the invention
Fowler ene compositions are proportionally mixed with emulsifier, then carry out homogeneous, and at emulsion or lotion, preservative and essence is added
Obtain emulsion.
In one embodiment, the present invention provides composition or dispersion of the invention in preparation beauty or cosmetic
Purposes in product.
In one embodiment, the present invention provides composition or dispersion of the invention in preparation for beauty or change
Purposes in the instrument of adornment.
Embodiment
The present invention is further illustrated referring to embodiment.Description to specific exemplary embodiment of the invention be for
The purpose of explanation and illustration.These descriptions are not intended to limit the invention to the precise form disclosed, and it will be apparent that root
According to the introduction of present specification, many changes and variations can be made.The mesh that exemplary embodiment is selected and is described
Be explain the specific principles of the present invention and its practical application so that those skilled in the art can be realized and utilize
A variety of different exemplary implementation schemes of the invention and various chooses and changes.
Embodiment 1：
Fullerene powder is taken, oil solubility aids after mixing by their mixture put into microjet high pressure homogenizer
In, 200MPa homogeneous 5 times, then temperature of charge is controlled at 15 degree, stirs 12h, centrifugal filtration obtains composition.
Using the state of transmission electron microscope observing fowler ene compositions, simultaneously particulate matter presence is not detected in 250000 times of amplification,
Illustrate that fullerene is dissolved in auxiliary material, as a result as shown in Figure 1.
Embodiment 2：
Crease-resistant compact eye cream
Embodiment 3：
Crease-resistant skin lightening face cream
Embodiment 4：
Anticreep strengthen the hair shampoo
Embodiment 5：The experiment of transdermal rate
Fowler ene compositions of the present invention are prepared according to embodiment 1.
Control group：Application number：200480005008.1 the fullerene complex of the cladding of micella disclosed in embodiment 1.
Experimental method：Select sucking pig skin as experimental subjects, respectively by fowler ene compositions (wherein SIMMONDSIA CHINENSIS SEED OIL：Octanoic acid
Certain herbaceous plants with big flowers acid glycerol three ester：Isobutyl palmitate is 4:5:1) fullerene complex with micella cladding carries out transdermal experiment comparison.It adopts
Drug transmitance analysis is carried out with LC-MS.
As the result is shown：After 6 hours, there is 80% transmitance in Ben Fule ene compositions, the compound of micella cladding is saturating
The rate of mistake is only 20%.
Conclusion：Composition of the present invention containing fullerene is brilliant violet color, and wherein fullerene is dissolved state, and what is obtained contains fowler
The composition property of alkene is stablized, and can be used for any external prescription, is highly susceptible to through keratoderma, it is easier to absorb and sharp
With effect is easier to play.
Embodiment 6：The preparation of oil solubility aids
Fullerene powder is taken, oil solubility aids after mixing by their mixture put into microjet high pressure homogenizer
In, 200MPa homogeneous 5 times, then temperature of charge is controlled at 15 degree, stirs 12h, centrifugal filtration obtains composition.
Dissolubility of the fullerene in single auxiliary material
The content that liquid phase demarcates wherein fullerene is 1mg/ml, shows that fullerene is effectively dissolved in the oil solubility aids of said ratio.
Jojoba Oil is vegetative grease, although to stablize much compared with other plant oil such as olive oil, linseed oil etc.,
It is or there are certain unstability of grease.Sad certain herbaceous plants with big flowers acid glycerol three ester：Height clearly spends tasteless grease, belongs to palm oil or coconut
The derivative of oil, it is extracted using hot fractional method.Since it and human skin have compatible feature, it has non-greasy matter
Sense, its extensibility can be improved by being added in creams or lotion, had lubrication and made the effect of skin softness.And there is the function of filtering ultraviolet
Can, be the extract in coconut, make emollients in cosmetics, solvent come using.The different monooctyl ester of palmitic acid acid：With certain transdermal characteristic,
And property is mild.The composition of the above different ratio of integrated survey finds SIMMONDSIA CHINENSIS SEED OIL：Sad three rouge of certain herbaceous plants with big flowers acid glycerol：Palmitinic acid
Different monooctyl ester 4:5:Under 1 conditions of mixture ratios, the stability of composition is more preferable, and skin absorption is best, and skin sense is milder.
Embodiment 7：Whitening spot-removing effect
Experimental method：After mouse is anaesthetized with 2.5% yellow Jackets, model group is pressed with 0.4% progesterone injection
0.02g/kg dosage mouse hind leg intramuscular injection, 6 times a week, continuous 4 weeks.Normal group presses 0.02g/kg intramuscular injection sterile injection
Use water.Healthy female mouse 60 are taken, 3 dosage groups are randomly divided into 6 groups, every group 10.Normal group, model group, one group of fowler
Ene compositions (wherein SIMMONDSIA CHINENSIS SEED OIL：Sad certain herbaceous plants with big flowers acid glycerol three ester：Isobutyl palmitate is 4:5:1) 3 dosage groups of external application
(0.10,0.20,0.40mg/ml)), 3% quinhydrones positive controls (0.69mg/ml).One group of 3 dosage treatment group is respectively small
Mouse modeling same day local skin topical administration, one time a day, continuous use 30 days.Normal group and model group are given in the corresponding time
Distilled water partial smearing；3% quinhydrones positive drug control group started local application, time and the same fullerene of the course for the treatment of in the modeling same day
Group.After administration 30 days, cervical dislocation puts to death mouse, and back unhairing takes rapidly hepatic tissue and the skin histology at coating position each 2
Block, one of ice-cold normal saline flushing remove blood, and filter paper blots, cuts liver and each 0.5g of skin, put respectively
It in the beaker for entering the pre- cold saline of 2.0ml, shreds in tissue, then the test tube of falling people, with high speed disperser 10r/min homogenate two
It is secondary, 10 seconds every time；Again with 3500r/rain revolving speed centrifugation 15 minutes, supernatant is taken, is tested.
As a result：Such as the following table 2
Table 2
Conclusion：Shown in table 2 as above, normal group is non-modeling, and it is to carry out drug-treated that model group, which is after modeling, and positive group is
The known quinhydrones with excellent whitening effect.After modeling success, the melanocyte number of model group be increased significantly, dermal inflammation cell
Number increases, and dermal vascular number is reduced, and compares basic, normal, high three administration groups and finds that its melanocyte quantity, corium inflammatory cell compare
Model group is low, and dermal vascular number obviously increases, and illustrates the whitening effect for having certain, and has certain concentration-dependent relation.
The present composition has remarkable efficacy for model group, positive controls, and composition of the invention has the work of whitening spot-removing
With.
Embodiment 8：Anti-oxidant smoothing wrinkle
Experimental method：6 weeks nude rats are selected in experiment, are divided into two groups, and every group 10, experimental group ear backside on the right side of nude mice
It puts the oil dissolubility fowler ene compositions (wherein SIMMONDSIA CHINENSIS SEED OIL：Sad certain herbaceous plants with big flowers acid glycerol three ester：Isobutyl palmitate is 4:5:1), daily
Twice, about 0.5g, control group are not administered every time.Under the conditions of cleaning, ventilation, drying, 22 ± 2 DEG C of room temperature, identical forage feed.
8 are respectively taken after medication 60 days, cervical dislocation takes its drug effect position and opposite side corresponding site skin to detect after putting to death.Observation
Experimental group water-soluble fullerene topical composition accounts for the influence of skin corium area ratio to skin collagen within 60 days.As a result：See
The present composition has remarkable result to the increase of skin corium collagen after table 3,60 days.
3 oil-soluble fullerene topical composition of table accounts for the influence of skin corium area ratio to skin collagen
Embodiment 9：Fullerene composite formula human body external application effect assessment of the present invention
The composition is added in conventional emulsions, is configured to new product emulsion.
Anti-acne experiment：Gender is random, 20 the age 18~55 years old, face has the tested of the acne of slight, moderate and severe
Person, using product 14 days, as a result as shown in Figures 2 and 3.
Desalinate microgroove experiment：20 35-55 years old age women have obvious wrinkle at canthus, use product 30 days
The colour of skin improves experiment：20 35-55 years old age women, the colour of skin is obscure, continuous use 4 weeks contain 3% this patent at
The face cream of the fullerene divided, it is each primary daily morning and evening.Data are obtained by questionnaire survey and photo analysis.It can be seen that being added to
The face cream of 3% fullerene has the effect of apparent bright color, whitening.As a result as shown in Figure 4
Light spot experiment：20 35-55 years old age women, locally there is light brown patch, use product 30 days
The experiment of strengthen the hair anticreep：There is alopecia to perplex crowd, male or female uses product 30 days
Anti- haze effect：By this patent fowler ene compositions (wherein SIMMONDSIA CHINENSIS SEED OIL：Sad certain herbaceous plants with big flowers acid glycerol three ester：Palmitinic acid is different
Monooctyl ester is 4:5:1) it handles skin explant 5 days, is then exposed in pollution environment.It is handled as the result is shown by this patent ingredient
Skin Cell state and blank group almost without difference.And the cutaneous manifestations damaged by haze go out damaged cell and obviously increase
It is more, as a result as shown in Figure 5.
As a result：
| Group | Anti-acne | Microgroove variation | The colour of skin improves | Light spot | Strengthen the hair anticreep |
| 80% | 65% | 70% | 50% | 60% |
Conclusion：Fowler ene compositions of the invention have beautification function, and anti-acne eliminates microgroove, improve the light spot effect of the colour of skin.
Beneficial effect of the present invention in summary
1, fullerene is molecular state in ene compositions containing fowler of the invention, and grain diameter is small, is easier in formula
It releases, and then is absorbed and used.
2, the preparation method of composition of the invention containing fullerene is simple and easy to do, is suitble to be prepared on a large scale.
3, the composition property of the invention containing fullerene is stablized, the preparation suitable for any external prescription.
4, the composition of the invention containing fullerene has the function of whitening, nti-freckle, anti-wrinkle.
Claims (10)
1. a kind of fowler ene compositions, the fullerene for dissolving or dispersing containing oil solubility aids and in oil solubility aids.
2. a kind of fullerene dispersion, the system contain fullerene and oil solubility aids, it is characterised in that the dispersion
50% or more in system, such as 60%, 70%, 80%, 90%, 95%, 99% or more partial size is less than 5nm.
3. according to the composition or dispersion of any one of preceding claims, which is characterized in that in addition to oil solubility aids and richness
It strangles except alkene, also containing at least one antioxidant.
4. according to the composition or dispersion of any one of preceding claims, which is characterized in that in addition to oil solubility aids and richness
It strangles except alkene, also contains at least one other active constituent.
5. according to the composition or dispersion of any one of preceding claims, which is characterized in that the composition or dispersion
System can be added in cosmetics or drug delivery system and/or slow-released system.
6. the preparation method of a kind of fowler ene compositions or dispersion and its preparing product, which is characterized in that the method
Include the following steps：Take fullerene powder, oil solubility aids, after mixing, after being handled by high pressure homogenizer, centrifugation and/
Or product is obtained by filtration；Optionally, the high pressure homogenizer is in 50-500MPa, preferably 100-300MPa, further preferably
200MPa homogeneous 1-10 times, preferably 3-8 times further preferred 5 times, then control temperature of charge at 0-25 DEG C, preferably 5-20
DEG C, further preferred 10-15 DEG C, stir 1-20h, preferably 5-15h, further preferred 12h.
7. the oil solubility aids are selected from according to the composition of any one of preceding claims or dispersion or method：Lotus lotus
Fragrant plant oil, sad certain herbaceous plants with big flowers acid glycerol three ester, isobutyl palmitate, isopropyl palmitate, myristyl myristate, lauric alcohol-octanoic acid
In ester/decylate, coconut oil last of the ten Heavenly stems ester, coconut acid methylester, coconut oil isodecyl ester, stearyl alcohol behenate, stearyl alcohol citrate,
Stearyl alcohol lactate, stearyl octanoate, stearyl alcohol palmitate, fish oil glycerol mixing esters, in sucrose polyoleate extremely
Few one kind, preferably Jojoba Oil, sad certain herbaceous plants with big flowers acid glycerol three ester, isobutyl palmitate, isopropyl palmitate, myristic acid nutmeg
At least one of ester, it is highly preferred that the oil solubility aids are that SIMMONDSIA CHINENSIS SEED OIL, sad certain herbaceous plants with big flowers acid glycerol three ester, palmitinic acid are different pungent
At least one of ester, most preferably, the oil solubility aids are that SIMMONDSIA CHINENSIS SEED OIL, sad certain herbaceous plants with big flowers acid glycerol three ester, palmitinic acid are different pungent
Ester, quality proportioning are (1-7)：(1-7)：(1-7), for example, 7：2:1,5:4:1,3:6:1,6:1:3,4:1:5,2:1:7,4：
5：1, preferably 4：5：1.
8. according to the composition of any one of preceding claims or dispersion or method, the fullerene be empty fullerene,
At least one of metal fullerene, heterocycle fullerene and embedded fullerene, including but not limited to fullerene C2n、M@C2n、M2@
C2n、MA@C2n、M3N@C2n、M2C2@C2n、M2S@C2n、M2O@C2nAnd MxA3-xN@C2nAny one of or mixtures thereof, wherein M and
A is metallic element, and the M and A are selected from any one in Sc, Y and lanthanide element；30≤n≤60；0≤x≤3,
Preferably, the fullerene is C60, C70, C76, C84, or mixtures thereof any one in Gd@C82 and its derivative, into
Preferably, the fullerene is C60 to one step.
9. the purposes of the composition or dispersion of any one of preceding claims in preparation beauty or cosmetic product, optionally
Ground, the beauty or cosmetic product are used for whitening spot-removing, anti-wrinkle, anti-acne, at least one of anti-haze or hair growing.
10. the composition or dispersion of any one of preceding claims are in preparation for the use in the instrument of beauty or makeup
On the way, optionally, the beauty or cosmetic product are used for whitening spot-removing, anti-wrinkle, anti-acne, at least one of anti-haze or hair growing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464288A (en) * | 2018-12-06 | 2019-03-15 | 上海莎伦巍化学科技有限公司 | A kind of fowler ene compositions and the Essence containing the fowler ene compositions |
| CN110946789A (en) * | 2019-12-31 | 2020-04-03 | 茂名市瑜丰沉香创意产业有限公司 | Hand cream containing agilawood and fullerene and preparation method thereof |
| CN113599307A (en) * | 2021-08-17 | 2021-11-05 | 北京福纳康生物技术有限公司 | Fullerene composition for hair care |
| US11253443B2 (en) | 2020-01-22 | 2022-02-22 | Max C. Champie | Skin products with C60 and niacin |
| CN114652619A (en) * | 2022-05-09 | 2022-06-24 | 中国科学院烟台海岸带研究所 | Active oil-soluble anthocyanin and preparation method and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110384641A (en) * | 2019-08-12 | 2019-10-29 | 中山市博深化学有限公司 | Skin care composition containing fullerene, eye cream and preparation method of eye cream |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009113426A1 (en) * | 2008-03-14 | 2009-09-17 | 財団法人ひろしま産業振興機構 | Anti-wrinkle composition and external skin composition |
| CN108201513B (en) * | 2016-12-16 | 2021-04-06 | 北京福纳康生物技术有限公司 | Hair composition and hair restorer |
| CN107519046A (en) * | 2017-08-01 | 2017-12-29 | 深圳慧镁尔科技有限公司 | A kind of anticreep strengthen the hair hair growth composition, preparation method and applications |
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2018
- 2018-07-16 CN CN201810777244.9A patent/CN108852865A/en active Pending
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464288A (en) * | 2018-12-06 | 2019-03-15 | 上海莎伦巍化学科技有限公司 | A kind of fowler ene compositions and the Essence containing the fowler ene compositions |
| CN110946789A (en) * | 2019-12-31 | 2020-04-03 | 茂名市瑜丰沉香创意产业有限公司 | Hand cream containing agilawood and fullerene and preparation method thereof |
| US11253443B2 (en) | 2020-01-22 | 2022-02-22 | Max C. Champie | Skin products with C60 and niacin |
| CN113599307A (en) * | 2021-08-17 | 2021-11-05 | 北京福纳康生物技术有限公司 | Fullerene composition for hair care |
| CN114652619A (en) * | 2022-05-09 | 2022-06-24 | 中国科学院烟台海岸带研究所 | Active oil-soluble anthocyanin and preparation method and application thereof |
| CN114652619B (en) * | 2022-05-09 | 2023-12-12 | 中国科学院烟台海岸带研究所 | Active oil-soluble anthocyanin as well as preparation method and application thereof |
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| CN109498478A (en) | 2019-03-22 |
| CN109498478B (en) | 2021-01-29 |
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