JP2005298503A - Moisture-retention cosmetic composition containing pulverized polygonatum offcinale - Google Patents
Moisture-retention cosmetic composition containing pulverized polygonatum offcinale Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Description
本願発明は、玉竹(アマドコロ、Polygonatum Officinale)を粉砕して得た玉竹粉を配合してなる保湿性化粧料組成物に関する。 The present invention relates to a moisturizing cosmetic composition comprising a ball bamboo powder obtained by pulverizing ball bamboo (Polygonatum Officinale).
外部環境から生体を保護する障壁(Barrier)として重要な役割をする肌(皮膚)は、水分の損失を妨げるために、表皮層での分化過程を経て、水分を含んだ薄い角質層を形成する。 この角質層は、外部環境と直接接触する肌の最外角層に位置しており、物理的および化学的に有害な成分の生体内への侵入を防止し、また、生体内より乾燥した外部環境下でも、生体内の水分損失を阻むと共に、角質層自らも適度の水分を保有して柔軟性を維持している。 肌の水分量は、真皮では約70%程度であるが、表皮側に移るにつれて水分量は減少し、最外角層の角質層では約10%〜約30%程度になる。 角質層に適度の水分が保持されている場合には、肌の弾力や柔軟性が維持されており、一般的に、正常な肌には約30%程度の水分や水溶性成分が含まれている。 また、健康な人の角質細胞には、高濃度の自然保湿因子(Natural Moisturing Factors, NMF)が存在しており、これが肌の水分保持を補助している。 Skin (skin), which plays an important role as a barrier that protects the living body from the external environment, forms a thin stratum corneum containing moisture through differentiation processes in the epidermis layer in order to prevent moisture loss. . This stratum corneum is located in the outermost stratum corneum of the skin that is in direct contact with the external environment, prevents the entry of physically and chemically harmful components into the living body, and is a dry environment from the living body. Even underneath, it prevents water loss in the body, and the stratum corneum itself retains flexibility by holding moderate water. The moisture content of the skin is about 70% in the dermis, but the moisture content decreases as it moves to the epidermis side, and is about 10% to about 30% in the stratum corneum of the outermost horny layer. When moderate moisture is retained in the stratum corneum, the elasticity and flexibility of the skin is maintained, and generally normal skin contains about 30% moisture and water-soluble components. Yes. In addition, high concentrations of natural moisturizing factors (NMF) are present in the horny cells of healthy people, which assists the moisture retention of the skin.
このような機能があるにもかかわらず、肌は、過酷な外部環境、すなわち、風雨、寒冷気候、日光などの他に、洗顔、髭剃り、冬季の室内暖房、そして、汚染した大気に露出し、また、加齢が進むにつれて老化という因子が加わるなどして、肌の水分は容易に損失してしまい、肌が乾燥しやすくなるので、このような現象を阻む肌用保湿剤が待望されている。 Despite this function, the skin is exposed to the harsh external environment, i.e. wind and rain, cold weather, sunlight, etc., as well as facial cleansing, shaving, winter indoor heating, and contaminated atmosphere. In addition, the skin moisture is easily lost due to factors such as aging as aging progresses, and the skin becomes easy to dry, so there is a long-awaited skin moisturizer that prevents this phenomenon. Yes.
保湿効果を示す物質は多数存在しており、また、そのような現象に対処するための研究も盛んに行われており、これまでに、角質層での水分量を増加させることのできる肌用保湿剤成分として、セラマイドなどの脂質成分、必須脂肪酸および脂質複合体などが知られている(非特許文献1を参照)。 There are many substances that show moisturizing effects, and research to deal with such phenomena has been actively conducted, so far, it has been used for skin that can increase the amount of moisture in the stratum corneum. Known moisturizer components include lipid components such as ceramide, essential fatty acids and lipid complexes (see Non-Patent Document 1).
最近、漢方への関心の高まりと相俟って、人体に安全な天然生薬源から人体に有用な成分を取得するための研究も活発に行われているる。 Recently, coupled with the growing interest in Kampo, active research is being conducted to obtain useful ingredients for the human body from natural herbal medicines that are safe for the human body.
古来より漢方では、補陰という概念が広く用いられているが、この概念を、現代のヒトの肌に当てはめてみると、肌の保湿作用と深く関連する。 肌の保湿は、肌の好ましい状態を実現する上で最も深刻な問題である、肌の乾燥に起因する皺への対処方法でもある。 Since ancient times, the concept of prosthetic shadow has been widely used in traditional Chinese medicine, but when this concept is applied to modern human skin, it is closely related to the moisturizing action of the skin. Moisturizing the skin is also a method for dealing with wrinkles caused by skin dryness, which is the most serious problem in realizing a desirable skin condition.
漢方生薬の中で補陰効果を奏する生薬の一つである玉竹(Polygonatum Officinale)は、アマドコロの根茎を薬用に供するものであり、地節、黄地、女委などの生薬名がある。 Polygonatum Officinale, one of the herbal medicines that have a prosthetic effect among herbal medicines, is used for medicinal rhizomes for medicinal purposes.
玉竹の起源植物であるアマドコロは、多年生の草本であり、その根茎である玉竹は、秋または早春に収穫されて、茎と髭根を取り除いたものを、日陰で乾燥するか、あるいは水蒸気に曝したものを日なたで乾燥したものを薬用に供する。 玉竹には、薬効成分として、コンバラマリン(convallamarin)、コンバラリン(convallarin)などのステロイダルサポニン(steroidal saponin)の他に、様々なフラボノイド(flavonoids)なども含まれており、これら成分は、強心作用、副腎皮質ホルモンと同様の作用、喉の渇きを緩和する作用、抗酸化作用、肌老化作用などを呈することが知られている。 東洋医学において、この薬の性味は「平」、「甘」であり、滋養、潤肺、止渇などを効能とし、虚弱体質、煩渇、糖尿病、狭心症などの症状に対して、液剤、丸剤または散剤の形態で服用する。
玉竹以外にも、効能がよく知られている漢方生薬でありながらも、化粧品成分として、そのまま利用しにくい生薬も少なくなく、そのような生薬については、水で抽出して得た抽出物(抽出液)が利用されていることが多い。 しかしながら、一般的に、多量の均質の生薬抽出物を取得することは難しいため、漢方生薬の薬効成分を効率的に取得できるまでには至っていないのが実情である。 In addition to jade bamboo, there are many herbal medicines that are well-known herbal medicines but are difficult to use as cosmetic ingredients. For such herbal medicines, an extract obtained by extraction with water ( Extract liquid) is often used. However, in general, since it is difficult to obtain a large amount of a homogeneous herbal extract, the actual situation is that it has not yet been possible to efficiently obtain the medicinal components of Chinese herbal medicine.
本願発明者らは、上掲した従来技術で認識されていた技術課題に鑑みて、多量の玉竹を含有しながらも、簡便に入手および利用できる化粧料組成物について鋭意研究を行ったところ、粉状化した玉竹は、玉竹の抽出物よりも多量の有用成分を含んでおり、なおかつ化粧料組成物への取り込みも非常に容易に行えるとの知見を得るに至ったのである。 すなわち、本願発明の要旨とするところは、玉竹を粉砕して得た玉竹粉を含む保湿性化粧料組成物にある。 In view of the technical problems recognized in the above-described prior art, the inventors of the present application conducted intensive research on a cosmetic composition that can be easily obtained and used while containing a large amount of bamboo. The powdered ball bamboo contains a larger amount of useful components than the ball bamboo extract, and it has been found that it can be easily incorporated into a cosmetic composition. That is, the gist of the present invention resides in a moisturizing cosmetic composition containing a ball bamboo powder obtained by grinding ball bamboo.
本願発明によると、所期の目的であった、玉竹に含まれる有用成分を多量に含有してなる化粧料組成物、すなわち、ヒトの肌に対して優れた保湿効果を奏する化粧料組成物が実現される。 According to the present invention, a cosmetic composition containing a large amount of useful components contained in cypress, which was the intended purpose, that is, a cosmetic composition having an excellent moisturizing effect on human skin. Is realized.
本願発明の構成を、以下に、詳細に説明する。 The configuration of the present invention will be described in detail below.
本願発明の保湿性化粧料組成物には、多量の玉竹粉が取り込まれているので、ヒトの肌に対して優れた保湿効果を奏する。 Since the moisturizing cosmetic composition of the present invention incorporates a large amount of bamboo and bamboo powder, it exhibits an excellent moisturizing effect on human skin.
本願発明の保湿性化粧料組成物には、玉竹粉を、約0.01重量%〜約30重量%の濃度で配合することが好ましい。 これはすなわち、玉竹粉の含有量が、約0.01重量%にも満たない場合には所望の肌保湿効果が得られず、また、約30重量%を超えてしまうと、玉竹独特の香りが過度に強くなってしまい、化粧品としての品質低下を招きかねないことによる。 In the moisturizing cosmetic composition of the present invention, it is preferable to blend ball and bamboo powder at a concentration of about 0.01 wt% to about 30 wt%. In other words, if the content of onion and bamboo powder is less than about 0.01% by weight, the desired skin moisturizing effect cannot be obtained. Is excessively strong and may lead to a reduction in quality as a cosmetic product.
玉竹の抽出物を、化粧料組成物に配合しようとしても、一般的に、その配合量には限度があり、玉竹粉によった場合の配合量には到底及ばない。 例えば、10%の玉竹抽出液を用いる場合で言えば、抽出液(原液)での玉竹含有量は10%に過ぎないので、この10%抽出液を10%だけ配合した製剤での玉竹の含量はわずか1%である。 これに対して、玉竹を粉砕して得た玉竹粉を用いれば、多量の玉竹を、直接かつ容易に、製剤内に添加することができるので、ヒトの肌に対して優れた保湿効果が期待できる。 Even if it is going to mix | blend an extract of a cypress with a cosmetics composition, generally the compounding quantity has a limit and it does not reach the compounding quantity at the time of using a bamboo and bamboo powder. For example, in the case of using a 10% onion extract, the content of the onion (stock solution) is only 10%. The bamboo content is only 1%. On the other hand, by using the ball and bamboo powder obtained by crushing the ball and bamboo, a large amount of ball and bamboo can be added directly and easily into the preparation, so it has excellent moisture retention for human skin. The effect can be expected.
本願発明の保湿性化粧料組成物は、次のような方法で取得できる。 The moisturizing cosmetic composition of the present invention can be obtained by the following method.
まず、栽培した原料玉竹を乾燥し、そして、乾燥した玉竹を加熱して煎った後に、粉砕機に適用して、そこで、細かく粉砕して粉体、すなわち、玉竹粉とする。 本願発明では、こうして取得された玉竹粉の含量に基づく保湿効果を検証すべく、動物実験および実用性試験を行った。 すなわち、動物またはヒトの肌(皮膚)の表皮水分損失量(Trans Epidermal Water Loss (TEWL))を測定したところ、玉竹粉含量の増加に伴って、肌の潤いが増して、保湿効果が改善されることが明らかになったのである。 First, the cultivated raw ball bamboo is dried, and the dried ball bamboo is heated and roasted, and then applied to a pulverizer, where it is finely pulverized to obtain a powder, that is, ball bamboo powder. In the present invention, an animal experiment and a practicality test were performed in order to verify the moisturizing effect based on the content of the bamboo and bamboo powder thus obtained. In other words, when measuring the epidermal water loss (TEWL) of animal or human skin (skin), the moisturizing effect increases with the increase of the bamboo and bamboo powder content, improving the moisturizing effect. It became clear that it was done.
つまり、本願発明は、前述の方法で取得された玉竹粉を含み、肌用保湿剤への用途に適した保湿性化粧料組成物を提供するものである。 In other words, the present invention provides a moisturizing cosmetic composition suitable for use as a skin moisturizing agent, comprising the ball and bamboo powder obtained by the above-described method.
本願発明の保湿性化粧料組成物は、前述の玉竹粉の他に、本願発明が奏する作用効果を実質的に損ねない限りは、これら作用効果を補助または改善するその他の保湿成分などをさらに加えることもできる。 このような成分として、セラマイド、グリセロール、グリセリンなどがあるが、これらに限定されない。 The moisturizing cosmetic composition of the present invention, in addition to the above-mentioned onion and bamboo powder, further contains other moisturizing ingredients that assist or improve these functions and effects as long as the effects of the present invention are not substantially impaired. It can also be added. Such components include, but are not limited to, ceramide, glycerol, glycerin and the like.
本願発明の保湿性化粧料組成物に用いられる玉竹粉は、湧出物、湧出液、湧出物または湧出液の乾燥粉末の形態で、そのまま塗布することもできるし、また、通常の外用剤または化粧料などの形態とすることもできる。 The ball bamboo powder used in the moisturizing cosmetic composition of the present invention can be applied as it is in the form of a spring, a spring, a spring or a dry powder of the spring, or a normal external preparation or It can also be in the form of cosmetics.
玉竹粉を含む本願発明の保湿性化粧料組成物は、肌保湿効果のための化粧品、洗顔剤、シャンプーなどの多様な製品において利用することができる。 本願発明の保湿性化粧料組成物を添加できる製品として、各種クリーム、ミルクローション、スキンローションなどの化粧品類、それに、シャンプー、リンス、クレンジング、洗顔剤、石けん、トリートメント、美容液などがあるが、これらに限定されない。 The moisturizing cosmetic composition of the present invention containing ball and bamboo powder can be used in various products such as cosmetics, facial cleansers, and shampoos for the skin moisturizing effect. The products to which the moisturizing cosmetic composition of the present invention can be added include cosmetics such as various creams, milk lotions, skin lotions, and shampoos, rinses, cleansings, facial cleansers, soaps, treatments, and cosmetics. It is not limited to these.
また、玉竹粉を含む本願発明の保湿性化粧料組成物は、溶液、乳化物、粘性型混合物などの形態とすることができる。 Moreover, the moisturizing cosmetic composition of the present invention containing the ball and bamboo powder can be in the form of a solution, an emulsion, a viscous mixture, or the like.
本願発明の保湿性化粧料組成物が利用できる製品として、例えば、乳液、クリーム、化粧水、エッセンス、パック、ジェル、パウダー、リップスティック、メークアップベース、ファウンデーション、ローション、軟膏、ゲル、パッチ、美容液、クレンジングフォーム、クレンジングクリーム、クレンジングウォーター、石けん、噴霧剤などがあるが、これらに限定されない。 Examples of products for which the moisturizing cosmetic composition of the present invention can be used include emulsions, creams, lotions, essences, packs, gels, powders, lipsticks, makeup bases, foundations, lotions, ointments, gels, patches, and cosmetics. Examples include, but are not limited to, liquids, cleansing foams, cleansing creams, cleansing water, soaps and sprays.
本願発明の保湿性化粧料組成物を利用した製品に、化粧料の剤形または使用目的に応じて、玉竹粉以外の成分を選択して取り込むことは、当業者であれば容易になしえることである。 It is easy for those skilled in the art to select and incorporate ingredients other than the ball and bamboo powder into the product using the moisturizing cosmetic composition of the present invention according to the cosmetic dosage form or purpose of use. That is.
本願発明の保湿性化粧料組成物に対して、保湿効果をさらに高める目的で、肌への吸収性を促進する物質を併用することができる。 For the purpose of further enhancing the moisturizing effect, a substance that promotes absorption into the skin can be used in combination with the moisturizing cosmetic composition of the present invention.
また、本願発明の保湿性化粧料組成物に、水溶性ビタミン、油用性ビタミン、高分子ペプチド、高分子多糖、スフィンゴ脂質、海草エキスなどを加えることもできる。 In addition, water-soluble vitamins, oily vitamins, polymer peptides, polymer polysaccharides, sphingolipids, seaweed extracts, and the like can be added to the moisturizing cosmetic composition of the present invention.
さらに、本願発明の保湿性化粧料組成物に、上記した成分に加えて、必要に応じて、通常の化粧料に配合される他の任意成分を組み合わせて用いることもできる。 このような任意成分として、油脂成分、保湿剤、エモルリエント剤、界面活性剤、有機顔料、無機顔料、有機粉体、紫外線吸収剤、防腐剤、殺菌剤、酸化防止剤、植物抽出物、pH調整剤、アルコール、色素、香料、血行促進剤、冷感剤、制汗剤、精製水などがあるが、これらに限定されない。 これら任意成分の配合量は、本願発明が奏する作用効果を実質的に損ねない量とすべきであり、好ましくは、本願発明の保湿性化粧料組成物の約0.01重量%〜約5重量%、好ましくは、約0.01重量%〜約3重量%の量に調整される。 Furthermore, in addition to the above-described components, the moisturizing cosmetic composition of the present invention can be used in combination with other optional components blended in a normal cosmetic as necessary. As such optional ingredients, oil and fat ingredients, moisturizers, emollients, surfactants, organic pigments, inorganic pigments, organic powders, UV absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjustment Examples include, but are not limited to, agents, alcohols, pigments, fragrances, blood circulation promoters, cooling agents, antiperspirants, and purified water. The blending amount of these optional components should be an amount that does not substantially impair the action and effect exhibited by the present invention, and preferably about 0.01 wt% to about 5 wt% of the moisturizing cosmetic composition of the present invention, Preferably, the amount is adjusted to about 0.01 wt% to about 3 wt%.
以下に、本願発明をその実施例に沿って説明するが、この実施例の開示に基づいて本願発明が限定的に解釈されるべきでないことは勿論である。 The present invention will be described below with reference to examples thereof, but it is needless to say that the present invention should not be construed in a limited manner based on the disclosure of the examples.
実施例1:玉竹粉の製造
栽培した原料玉竹を乾燥した。 この乾燥した玉竹を、加熱して煎った後に、粉砕機で細かく粉砕して、玉竹粉を得た。
Example 1: Manufacture of onion and bamboo powder The onion and cultivated raw material was dried. The dried ball bamboo was heated and roasted, and then finely pulverized with a pulverizer to obtain a ball bamboo powder.
実験例1:玉竹粉の保湿効果の検定
実施例1で得た玉竹粉の濃度依存的な保湿効果を検証するために、以下の手順で実験を行った。
Experimental Example 1: Examination of the moisturizing effect of the bamboo and bamboo powder In order to verify the concentration-dependent moisturizing effect of the bamboo and bamboo powder obtained in Example 1, an experiment was performed in the following procedure.
まず、各種玉竹濃度に対応する量の玉竹粉を、それぞれ水に分散させて後、水分損失測定機(evaporimeter、ServoMED社)で、表皮水分損失量を測定した。 すなわち、健康な20匹のモルモットを実験動物として準備し、それらの背中の同じ部位を剃毛して現れた表皮上の任意の箇所に、ラウリル硫酸ナトリウム(Sodium Lauryl Sulfate; SLS)を塗布して、皮膚に損傷を与えた。 次いで、各種濃度(0.01%、0.1%、1%、5%、10%)の玉竹粉分散液を、各損傷箇所に塗布した後に、水分蒸発測定機で表皮水分損失量を測定して、それを初期値とした。 以後、4日間、損傷部位に同濃度の玉竹粉分散液を塗布し、5日目に水分蒸発測定機で測定して得た数値を記録した。 その測定結果を、以下の表1に示した。 First, each amount of onion and bamboo powder corresponding to various onion and bamboo concentrations was dispersed in water, and then the epidermal water loss was measured with a water loss measuring device (evaporimeter, ServoMED). In other words, 20 healthy guinea pigs were prepared as experimental animals, and sodium lauryl sulfate (SLS) was applied to any part of the epidermis that appeared after shaving the same part of their backs. Damaged the skin. Next, after applying the bamboo and bamboo powder dispersions of various concentrations (0.01%, 0.1%, 1%, 5%, 10%) to each damaged part, the skin water loss was measured with a moisture evaporation measuring device. It was measured and used as the initial value. Thereafter, a ball bamboo powder dispersion of the same concentration was applied to the damaged part for 4 days, and the value obtained by measuring with a moisture evaporation measuring machine on the 5th day was recorded. The measurement results are shown in Table 1 below.
実験例2:玉竹粉を配合した化粧料によるヒトの肌美容効果
玉竹粉に関して、ヒトの肌での美容効果を検証するために、以下の化粧料を用いて実験を行った。
Experimental Example 2: Human skin beauty effect with cosmetics blended with bamboo and bamboo powder In order to verify the beauty effects on human skin with respect to the bamboo and bamboo powder, an experiment was conducted using the following cosmetics.
実験例2−1:乳化剤
下記表2に記載の化粧料成分(原材料)を準備した。 そして、乳相成分と水相成分を、70℃にて完全溶解させ、次いで、7,000rpmで、5分間かけて乳化を進行せしめて、クリーム状の化粧料Aおよび化粧料Xを調製した。
Experimental Example 2-1 Emulsifier Cosmetic ingredients (raw materials) shown in Table 2 below were prepared. Then, the milk phase component and the water phase component were completely dissolved at 70 ° C., and then emulsification was allowed to proceed for 5 minutes at 7,000 rpm to prepare creamy cosmetic A and cosmetic X.
実験例2−2:パック剤
下記表3に記載の化粧料成分(原材料)を準備した。 そして、水相成分を、70℃にて完全溶解させて、40℃に冷却した後、アルコール相を添加して完全溶解せしめて、可溶化パック剤(化粧料Bおよび化粧料Y)を調製した。
Experimental Example 2-2: Packing agent Cosmetic ingredients (raw materials) described in Table 3 below were prepared. Then, the aqueous phase component was completely dissolved at 70 ° C. and cooled to 40 ° C., and then the alcohol phase was added and completely dissolved to prepare a solubilized pack agent (Cosmetic B and Cosmetic Y). .
実験例2−3:試験結果
乳化剤およびパック剤を用いた実験の結果を、以下の表4に記載した。
Experimental Example 2-3: Test Results The results of experiments using emulsifiers and pack agents are shown in Table 4 below.
実施例2:化粧料組成物の利用形態
本願発明の保湿性化粧料組成物を配合した各種製剤を調製した。 なお、本実施例での成分配合量の単位は、特に断りのない限り、重量%で表示してある。
Example 2: Use form of cosmetic composition Various preparations containing the moisturizing cosmetic composition of the present invention were prepared. In addition, the unit of the component compounding amount in a present Example is displayed by weight%, unless there is particular notice.
1:石けん
以下の表5に記載の配合比に従った材料を用いて石けんを調製した。
1: Soap A soap was prepared using a material according to the blending ratio shown in Table 5 below.
以下の表6に記載の配合比に従った材料を用いてミルクローションを調製した。
以下の表7に記載の配合比に従った材料を用いて化粧用クリームを調製した。
以下の表8に記載の配合比に従った材料を用いてパックを調製した。
以下の表9に記載の配合比に従った材料を用いて美容液を調製した。
本願発明の保湿性化粧料組成物は、ヒトの肌に対して改善された肌保湿効果を奏するものであり、肌用保湿剤の有効成分として極めて有用である。 The moisturizing cosmetic composition of the present invention exhibits an improved skin moisturizing effect on human skin, and is extremely useful as an active ingredient of a skin moisturizing agent.
Claims (3)
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KR1020040023856A KR20050098583A (en) | 2004-04-07 | 2004-04-07 | Cosmetic composition containing polygonatum officinale powder for skin hydrating |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100733324B1 (en) * | 2005-12-06 | 2007-06-29 | 주식회사 케이티앤지 | Compositions for Preventing Hair Loss or Stimulating Hair Growth |
JP2011102275A (en) * | 2009-11-11 | 2011-05-26 | Shiseido Co Ltd | Tie2-activating agent, agent for maturing, normalizing or stabilizing blood vessel, lymphatic vessel-stabilizing agent, and wrinkle-preventing/ameliorating agent and dropsy-ameliorating/preventing agent |
JP2012509255A (en) * | 2008-11-19 | 2012-04-19 | 株式會社アモーレパシフィック | Antioxidant cosmetic composition containing smoked peony, jade bamboo or lily extract |
WO2012101741A1 (en) * | 2011-01-24 | 2012-08-02 | 株式会社資生堂 | Tie-2 activator, agent for maturation, normalization, or stabilization of blood vessels, lymph vessel stabilizing agent, wrinkle prevention/improvement agent, and edema improvement/prevention agent |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20230100952A (en) | 2021-12-29 | 2023-07-06 | 주식회사 한국인삼공사 | Genetic Marker Having Single Nucleotide Polymorphism For Distinguishing Polygonatum |
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JPH03190809A (en) * | 1989-12-21 | 1991-08-20 | Shiseido Co Ltd | Skin external preparation |
JPH07277944A (en) * | 1994-04-11 | 1995-10-24 | Narisu Keshohin:Kk | Melanism inhibitor |
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JP2001106618A (en) * | 1999-10-04 | 2001-04-17 | Masao Takita | Bleaching skin preparation for external use |
JP2002348246A (en) * | 2001-05-23 | 2002-12-04 | Shiro Matsuda | Method for preparing powder preparation of chinese crude drugs |
JP2004091411A (en) * | 2002-09-02 | 2004-03-25 | Pola Chem Ind Inc | Hair-growing material and skin care preparation for external use containing the same |
JP2005112793A (en) * | 2003-10-08 | 2005-04-28 | Norihide Yamaguchi | Bleaching cosmetic |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100733324B1 (en) * | 2005-12-06 | 2007-06-29 | 주식회사 케이티앤지 | Compositions for Preventing Hair Loss or Stimulating Hair Growth |
JP2012509255A (en) * | 2008-11-19 | 2012-04-19 | 株式會社アモーレパシフィック | Antioxidant cosmetic composition containing smoked peony, jade bamboo or lily extract |
KR101537292B1 (en) * | 2008-11-19 | 2015-07-16 | (주)아모레퍼시픽 | Antioxidant cosmetic composition containing extracts of processed peony, Polygonati rhizoma or lily |
JP2011102275A (en) * | 2009-11-11 | 2011-05-26 | Shiseido Co Ltd | Tie2-activating agent, agent for maturing, normalizing or stabilizing blood vessel, lymphatic vessel-stabilizing agent, and wrinkle-preventing/ameliorating agent and dropsy-ameliorating/preventing agent |
WO2012101741A1 (en) * | 2011-01-24 | 2012-08-02 | 株式会社資生堂 | Tie-2 activator, agent for maturation, normalization, or stabilization of blood vessels, lymph vessel stabilizing agent, wrinkle prevention/improvement agent, and edema improvement/prevention agent |
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