JPH10182417A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin, which shows new effects, e.g. in particular, prevention of the skin from being rough, dry or eczematous, by compounding a combination of given herbal medicine(s) and edible plant(s). SOLUTION: This preparation for external use for skin contains a combination of the following herbal medicines, namely, Rehmannia glutionosa from Rehmannia glutinosa Liboschitz var. purpurea Makino root, Angelica acutiloba from Angelica acutiloba Kitagawa root, Coix laryma-jobi from Coixlachryma- jobi var. mayuen Stapf L. seed, Glycyrrhiza glabra from Glycyrrhiza uralensis Fischer or Glycyrrhiza glabra Lnnc root or stem, with an essence of Perilla frutescens Britton var. acuta Kudo stems, leaves or seeds extracted with water or alcohol, or their dried powder.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin for keeping the skin healthy.

[0002]

2. Description of the Related Art In general, land yellow, which is known as a crude drug, is a red croaker (Rehmannia glutinosa Liboschi) that is cultivated in China and in Japan (Nara Prefecture).
tz var.purpurea Makino) or the roots of related plants are dried as they are or steamed and then dried. The former is called kang (dry) jiou and is a yellow or yellow-brown columnar shape (about 1 cm in diameter, 5 to 10 cm in length), and the latter is called juk (ripe) jiou and is a black-brown mass. The main component is mannitol (mannit). Such land yellow has been used as a conventional Chinese medicine formulation for blood supplementation, tonic, and hemostatic.

[0003] Toki, also known as a crude drug, is obtained by drying or blanching the roots of perennial tortoise (Angelica acutiloba Kitagawa), a perennial herb of the Apiaceae family that naturally grows in mountainous areas such as Nara Prefecture and Hokkaido. Are dried, and all of them are flexible and have unique aroma and sweetness.
Such a result includes about 0.2% of essential oil (butylidenephthalide, a unique fragrance component) and bergapten, and is a sedative and silicic medicine as a conventional Chinese medicine.

[0004] Furthermore, yokuinin, which is known as a crude drug, is cotyledon (Coix la
chryma-jobi var. mayuen Stapf L.) is a crude drug consisting of seeds (that is, fruits excluding the seed coat), and those polished to edible grains contain about 14% protein. Conventional Chinese herbal prescriptions for such yoquinin include diuresis, analgesic and anti-inflammatory drugs.

[0005] Licorice, which is also described in the pharmacopoeia, is a leguminous family produced in Spain, Siberia and China.
Glycyrrhiza ur, a medicinal plant of guminosae)
alensis Fischer or Glycyrrhiza glabra Lnne) is a crude drug consisting of the roots or rhizomes (also called creeping stalks or strons), and is dried as it is (licorice with skin) or without cork skin (liquorice licorice). Licorice is known to contain glycyrrhizin, liquitiline, sucrose, glucose, mannitol, asparagine, and the like, and has been used as a cough, a prophylactic, and an analgesic.

[0006] Also, perilla (Pe), an annual herb of the Labiatae family
Rilla frutescens Britton var. acuta Kudo) is widely used in the field of foodstuffs such as flavorings by using its foliage or seeds as an edible portion, and particularly cultivars called akadiso or aodiso are well known.

[0007]

As described above, in the prior art, there is no example in which any of the crude drugs of Jiwang, Toki, and Yokuinin has been used as an external preparation for skin that keeps the skin healthy. No effective utilization has been achieved by blending the crude drug as an essential component.

[0008] Licorice and perilla have not been used as external preparations for keeping the skin healthy, nor have they been added to the above three types of crude drugs.

[0009] Therefore, an object of the present invention is to combine and combine the above-mentioned prescribed crude drugs and edible plants,
It is an object of the present invention to provide a skin external preparation as a novel and effective use, and to provide a skin external preparation that is particularly useful for eliminating rough skin, dry skin, eczema, and the like.

[0010]

Means for Solving the Problems In order to solve the above-mentioned problems, the present invention provides a method of rehmannia glutinosa Liboschitz var. Purpurea Mak.
ino), a crude drug consisting of roots
lica acutiloba Kitagawa) is a herbal medicine consisting of the roots of the roots, and Gramineae barley (Coix lachryma-jobi var.m.
ayuen Stapf L.), an external preparation for skin containing yoquinin, a crude drug consisting of seeds.

[0011] In addition, Rehmannia spp.
Annia glutinosa Liboschitz var.
cutiloba Kitagawa) is a crude drug consisting of the roots of Toki, Grape family (Coix lachryma-jobi var.mayuen Stapf)
L.), a herbal medicine consisting of the seeds of Yokuinin and Glycyrrhiza uralensis Fischer or Glyc
It was a skin external preparation containing licorice, a crude drug consisting of the roots or rhizomes of yrrhiza glabra Lnne).

[0012] In addition, Rehmandaceae
Annia glutinosa Liboschitz var.
cutiloba Kitagawa) is a crude drug consisting of the roots of Toki, Grape family (Coix lachryma-jobi var.mayuen Stapf)
L.), a herbal medicine consisting of the seeds of L.), legume licorice (Glycyrrhiza uralensis Fischer or Glycyrrh)
Licorice and Lamiaceae Perilla (Perilla frutescens Britton va), which are crude drugs consisting of roots or rhizomes of iza glabra Lnne
An external preparation for skin containing foliage or seeds of r. acuta Kudo).

Although the details of the components contained in the external preparation for skin of the present invention and the mechanism of action thereof are not clear, from the experimental results described below, the components contained in each crude drug and the like act synergistically, It is presumed that the action of keeping the healthy (activation action) is exhibited.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The land yellow, toki, yokunin, licorice and perilla used in the present invention are all well known as crude drugs or foods, and can be obtained as commercially available Chinese herbs or vegetables. As mentioned above, land yellow is a scrophulariaceae (Rehmannia glutinosa Liboschitz va) cultivated in China and in Japan (Nara Prefecture).
r. purpurea Makino) or the roots of related plants are dried as they are or steamed and then dried.

In addition, Toki is a perennial herb perennial herb (Angelica) that grows naturally in mountainous areas such as Nara Prefecture and Hokkaido.
The roots of acutiloba Kitagawa) are either dried as they are or blanched and dried.

Furthermore, yokuinin is an annual herb of the Poaceae family (Coix lachryma-jobi var. Mayue).
n Stapf L.) is a crude drug consisting of seeds (ie, fruits without the seed coat).

Licorice is a licorice (Glycyrrhiza uralensis Fisc) which is a medicinal plant of the legume family (Leguminosae).
Her or Glycyrrhiza glabra (Lnne) is a herbal medicine that has its roots or rhizomes intact or has the cork skin removed.

Also, perilla frutescens Britton
var.acuta Kudo) has been cultivated in Japan and China since ancient times, and all plant parts have aroma,
Usually, seeds that ripen to the leaves of the stems or the bottom of the tubular sepals are used. Further, it may include a general closely related species such as the above-mentioned perilla cultivars.

By the way, there are many varieties (cultivars) that have been improved by cultivation as closely related species of perilla, such as chili menjiso, whose leaves are shrunk, green ones on one side of the leaves, and green on both sides of the leaves. Aodiso and the like.

The crude drug or perilla described above is obtained by pulverizing or grinding a dried product to be powdered and then mixed with an appropriate skin-adhering base as it is, or water or an alcohol such as ethyl alcohol at an appropriate temperature. The extract is appropriately diluted and mixed with a cream, ointment, emulsion or the like for use.

For powdering, the active ingredient is easily dispersed in a base such as cream, ointment, emulsion, etc.
The following particles are preferable, and in order to obtain a powder particle size such that there is no rough feel when applied to the skin,
It is preferable to pulverize the particles into particles of about 10 to 50 μm.

In the extraction operation using water as an extraction solvent, extraction is performed using a stainless steel tank with water containing 3% or less of acid or alkali at a water temperature of 80 to 130 ° C. for about 20 minutes to 1 hour. It is preferable to separate and purify the liquid component by filtration or centrifugation. In the case of performing alcohol extraction, it is preferable to perform the extraction at a temperature not lower than the normal temperature and not higher than the boiling point for efficient production with stable quality.

Since the obtained extract has too strong an effect on the skin if it is used as it is, it is usually diluted with purified water or the like to about 1000 to 5000 times before use.

The form of the external preparation for skin containing the powder or extract of the ground yellow, toki, yokunin, licorice, perilla or the extract obtained in this manner is not particularly limited, but may be an aqueous solution, an emulsion (such as skin milk). , Creams, ointments, powders and the like, which are easy to apply, are convenient.

The amount of the extract or the dry powder to be mixed in these skin external preparations is 0.002 to 0.004 in terms of dry matter in the total amount of the skin external preparations containing ground yellow, Toki and yoquinin as essential components. % (% Is% by weight, the same applies hereinafter).

In the case of an external preparation for skin containing essential components of ground yellow, toki, yokunin and licorice, it is preferably 0.002 to 0.008% of the total amount in terms of dry matter.

In the case of an external preparation for skin containing essential components of ground yellow, toki, yokuinin, licorice and perilla, it is preferable that the amount is 0.003 to 0.008% of the total amount in terms of dry matter.

If the amount of the extract or the dry powder is less than the above-mentioned predetermined range, the desired effect cannot be obtained.
This is because the action on the skin is too intense or the like, which is not preferable.

[0029]

[Example] 140 g of ground yellow, 140 g of toki,
240 g of Yokuinin and 4 liters of water (tap water) are mixed in a stainless steel container, and the liquid temperature is heated to about 120 ° C. with an electric heater, and the mixture is extracted for 30 minutes. 2.4 liters of an extract was obtained. Purified water was added to the obtained extract to prepare a 2000-fold diluted solution (Example 1) and a 4000-fold diluted solution (Example 2), which were used as a test lotion.

In addition, 140 g of ground yellow in dry matter weight,
40 g, 240 g of yoquinin and 240 g of licorice, and 4 liters of purified water were mixed in a stainless steel container, and the solution was heated to about 120 ° C. with an electric heater and extracted for 30 minutes. As a result, 2.2 liters of an extract at room temperature was obtained. Purified water was added to the obtained extract to prepare a 2000-fold diluted solution (Example 3) and a 4000-fold diluted solution (Example 4), which were used as a test lotion.

In addition, 140 g of ground yellow in dry matter weight,
40 g, 210 g of yokinin, 210 g of licorice and 280 g of perilla leaves (including stems) and 4 liters of purified water were mixed in a stainless steel container, and the solution was heated to about 120 ° C. with an electric heater and extracted for 30 minutes. After the solids were filtered off, the mixture was allowed to cool to obtain 2 liters of an extract at room temperature. Purified water was added to the obtained extract to give a 2000-fold diluted solution (Example 5), and 4
000-fold dilutions (Example 6) were prepared and used as test lotions.

These lotions (Examples 1 to 6), Comparative Example 1 (purified water) and Comparative Example 2 (white petrolatum) were subjected to the following tests to confirm their skin activating activities.

(Skin activation test) 20 to 25 adult women with rough or dry skin (shown as examples in Tables 1 to 6) were applied to the face once a day with the above lotion. ,
After 14 days, a sensory test was performed to determine the degree of improvement for each symptom group.

The degree of improvement is determined by the judgment of both the person and the third party (judgment person) in accordance with the following criteria, and the judgment criterion is “very effective (when the symptoms disappear)”.
2 points for "effective" (when both the subject and the judge judged that the symptom was improved) and 1 for "slightly effective (when it was judged that only the person improved the symptom)"
The evaluation was evaluated in four steps with the point, "no effect (other than above)" as 0, and the average score was multiplied by 100. These results are shown in Tables 1 to 6 as the degree of improvement of rough skin or the degree of improvement of dry skin.

[0035]

[Table 1]

[0036]

[Table 2]

[0037]

[Table 3]

[0038]

[Table 4]

[0039]

[Table 5]

[0040]

[Table 6]

As is clear from the results of Tables 1 to 6, the lotions of Examples 1 to 6 are more remarkable for both dry skin and rough skin than the purified water or white petrolatum as comparative examples. Showed an excellent improvement effect.

[0042]

As described above, the present invention relates to a skin external preparation containing a crude drug consisting of ground yellow, Toki and yoquinin, or a skin external preparation containing licorice in addition to the above three crude drugs, or As a skin external preparation to which perilla is added in addition to the crude drug of the present invention, a new and effective use of a composition in which 3 to 5 kinds of predetermined crude drugs are blended as an essential component is provided, and particularly, rough skin, dry skin, eczema, etc. There is an advantage that an external preparation for skin can be provided which is useful for solving the problem.

Claims (4)

[Claims] [1] Rehmanni
a glutinosa Liboschitz var. purpurea Makino) is a crude drug consisting of the roots of the yellowtail and Aceraceae (Angelica acuti)
loba Kitagawa) and Toki, a crude drug consisting of roots, and coix lachryma-jobi var.mayuen Stapf
An external preparation for skin containing yoquinin which is a crude drug comprising the seed of L.). 2. Rehmanni (Rehmanni)
a glutinosa Liboschitz var. purpurea Makino) is a crude drug consisting of the roots of the yellowtail and Aceraceae (Angelica acuti)
Toki, a crude drug consisting of the roots of Loba Kitagawa, Yokuinin, a crude drug consisting of the seeds of the seeds of Coixlachryma-jobi var. mayuen Stapf L. and Glycyrrhiza uralensis Fischer or Glycyrrhiz
a glabra Lnne), an external preparation for skin containing licorice, a crude drug consisting of the root or rhizome. 3. Rehmanni (Rehmanni)
a glutinosa Liboschitz var. purpurea Makino) is a crude drug consisting of the roots of the yellowtail and Aceraceae (Angelica acuti)
Toki, a crude drug consisting of the roots of loba Kitagawa), Yokuinin, a crude drug consisting of seeds of the seeds of Coixlachryma-jobi var. mayuen Stapf L., Glycyrrhiza uralensis Fischer or Glycyrrhiza
perilla frutescens Britton var. ac, a herbal medicine consisting of the root or rhizome of glabra Lnne
An external preparation for the skin comprising the foliage or seeds of uta Kudo). 4. The external preparation for skin according to any one of claims 1 to 3, wherein the foliage or seeds of the crude drug or perilla is a powder of the dried product or an extract of water or alcohol.