CN112190535A - Anti-aging repairing microcapsule powder prepared from functional peptide composite hypecoum hainanense stem cells and preparation method thereof - Google Patents
Anti-aging repairing microcapsule powder prepared from functional peptide composite hypecoum hainanense stem cells and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The invention provides an anti-aging repairing microcapsule powder prepared from functional peptide composite hypecoum hainanense stem cells and a preparation method thereof, wherein the repairing microcapsule powder comprises the following components in parts by weight: functional components, surfactant, adhesive, wetting agent, antioxidant, cross-linking agent, wall material, antibacterial agent and deionized water; the functional components comprise: oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, and anise stem cell extract. The invention combines various functional peptides with hypecoum erectum stem cells to generate a synergistic anti-aging repairing effect. The repairing microcapsule powder is in a flowing white superfine powder shape, the particle size is about 3-20 mu m, and an electron microscope photo is in a granular shape. The color, appearance, fluidity and hand feeling are not changed within three years after production, and the detection value of the amino acid content is stable. The repairing microcapsule powder of the white ultrafine powder is dissolved into floccules by pressing with hands, and when the repairing microcapsule powder is applied to the face, the repairing microcapsule powder melts into cream, is smooth and fine, can be quickly absorbed by the epidermis of the skin within a few seconds, and the absorption effect is obviously improved.
Description
Technical Field
The invention belongs to the technical field of skin care and nursing, and particularly relates to anti-aging repairing microcapsule powder prepared from functional peptide composite hypecoum erectum stem cells and a preparation method thereof.
Background
With the rapid development and wide application of science and technology, people have higher and higher requirements on the components of skin care products, and the development of the skin care products integrating nutrition and natural multiple functions is a trend of the development of the cosmetic industry, and simultaneously brings a brand new development opportunity for the cosmetic industry. The skin care products have been gradually developed from original chemical beauty treatment and plant beauty treatment to biological beauty treatment and gene beauty treatment. At present, the main component of biological skin care products is bioactive polypeptide, most of which are cell growth factors or functional short peptides, the content of which in vivo is extremely small, but the biological activity is extremely high, and the biological skin care products can play a biological regulation role in physiological functions and metabolic activities of various cells, directly or indirectly influence the growth, division, differentiation, proliferation and migration of various cells, thereby achieving various effects of wrinkle removal, moisture preservation, relaxation, whitening and the like. The biological activity of polypeptides has opened up new molecular applications in the fields of dermatology and skin care.
The experimental results of the polypeptide Peptide published in paris in 2002 show that the same skin improvement effect can be obtained only by using one percent of vitamin a, and the polypeptide Peptide is milder than vitamin a and does not cause skin red swelling like the skin obtained after the vitamin a is used.
The polypeptide applied to the beauty cosmetics has the advantages of incomparable ratio:
1) the super-strong activity: the polypeptide has the greatest characteristic of high activity, can exert the beautifying effect by extremely low dosage, and is generally used for end products, and the content of the polypeptide is microgram level.
2) The effect is mild and definite: the important characteristic of polypeptide differentiation from other materials such as hormones and injectable products is that the effect is mild but definite.
3) Extremely high safety: due to the homology of the polypeptide and body substances, the excellent compatibility of the polypeptide as anti-wrinkle and anti-aging of the face is ensured, and in addition, due to the good transdermal property, the potential safety hazard caused by injection is avoided.
4) Activity diversity: because the physiological process of the skin is formed by various biochemical and molecular biological links, a huge active polypeptide molecule library can be reasonably designed by utilizing the modern basic medical theory according to various biochemical mechanisms, thereby causing the activity diversity of the polypeptide for beautifying.
5) Easy absorption: compared with collagen, the molecular weight of the polypeptide is smaller, and the polypeptide can further enter the skin to play a role.
6) The mechanism is clear: the production of each active cosmetic polypeptide is independent of a biochemical physiological mechanism, and the action principle of the polypeptide enables people to be 'seen' and 'seen clearly'.
7) The quality is controllable: each applied active polypeptide is a single substance, and compared with a plant extract, the quality of the active polypeptide is easy to control, and the purity of the active polypeptide can reach more than 99%.
Due to extremely high safety and wide and efficient biological activity, the biological polypeptide active matter becomes an important research field for development, production and application. The active polypeptide has the effects of repairing, resisting wrinkles and aging, whitening and removing freckles, replenishing water and moisturizing, removing eye bags, enlarging breasts, slimming, promoting eyelash growth, preventing alopecia and the like, and is the basis for developing functional products. The successful application of the active polypeptide in the aspect of beauty treatment breaks through the boundary of the traditional skin care products, shows great potential and is a revolution in the field of cosmetology.
The application of bioactive peptide in cosmetic components comprises cell proliferation activity, stability, safety, and information transfer effect. Based on these biological activities, these specific peptides need to exert their effects in a good way and strategy. And the compound can produce unexpected effects by being compounded with some rare maintenance components with excellent performance.
However, the conventional polypeptide lyophilized powder used in the same type of cosmetics in the current market has a single effect due to the limitation of compatibility among the components, and the absorption and utilization rate on skin is low and the effect is difficult to be highlighted.
The other serious problem is that the activity is unstable under the condition of normal temperature storage, the transportation time of the freeze-dried powder under the condition of normal temperature is not more than one month, and the freeze-dried powder needs to be refrigerated in a refrigerator at other times. The shelf life of the packaging bag after being unsealed and dissolved is only three days, and the freeze-dried powder can be deteriorated in less than three days if the packaging bag is stored at normal temperature.
Disclosure of Invention
In view of the above, in order to overcome the defects of the prior art, the invention provides the anti-aging repairing microcapsule powder prepared from the functional peptide composite hypecoum erectum stem cells, which is optimized in compatibility and can be stored for three years at normal temperature without losing biological activity.
The repair microcapsule powder provided by the invention comprises: functional components, surfactant, adhesive, wetting agent, antioxidant, cross-linking agent, wall material, antibacterial agent and deionized water;
the functional components comprise, by weight of 100%: oligopeptide-50.6-1.9%, carnosine 0.9-3.0%, palmitoyl hexapeptide-120.7-2.3%, acetyl hexapeptide-10.8-2.5%, collagen amino acids 0.6-3.5%, nicotinamide 0.5-1.5%, soluble collagen 2.5-7% and anise dry cell extract 0.5% -5%;
the surfactant includes: 0.2-0.4% of glyceryl caprylate and 3% -8% of silica silylate;
the adhesive comprises: 3.5 to 9 percent of sodium carboxymethyl starch and 4.5 to 7.5 percent of polyethylene glycol;
the wetting agent comprises: 3.1 to 5 percent of dipropylene glycol and 0.4 to 0.6 percent of propylene glycol;
the water-soluble antioxidant is: ascorbic acid 0.4-1.6%;
the fat-soluble antioxidant is: 0.01-2% of natural vitamin E;
the cross-linking agent: 3.3 to 6 percent of triethanolamine;
the wall material is as follows: 4.5% -10.5% of methyl methacrylate cross-linked polymer;
3.1-6.55% of antibacterial agent, which comprises water-soluble antibacterial agent and fat-soluble antibacterial agent;
the balance weight is deionized water.
Further, the functional components comprise, by 100% by weight: oligopeptide-50.7-1.3%, carnosine 1.0-2.3%, palmitoyl hexapeptide-120.9-2.1%, acetyl hexapeptide-10.9-1.7%, collagen amino acids 2.0-3.2%, nicotinamide 0.7-1.3%, soluble collagen 3.5-6% and anise dry cell extract 1.1% -4.6%;
the surfactant includes: 0.2-0.3% of glyceryl caprylate and 3.5% -6.5% of silica silylate;
the adhesive comprises: 4.5 to 7.5 percent of sodium carboxymethyl starch and 5 to 6.5 percent of polyethylene glycol;
the wetting agent comprises: 3.4 to 4.3 percent of dipropylene glycol and 0.35 to 0.45 percent of propylene glycol;
the water-soluble antioxidant is: ascorbic acid 0.7-1.3%;
the fat-soluble antioxidant comprises: natural vitamin E0.08-1.6%;
the cross-linking agent is: 3.4 to 5.5 percent of triethanolamine;
the wall material is as follows: 7.5% -10% of methyl methacrylate cross-linked polymer;
3.5-5.0% of antibacterial agent, wherein the antibacterial agent comprises water-soluble antibacterial agent and fat-soluble antibacterial agent;
the balance weight is deionized water.
Further, the functional components comprise, by 100% by weight: oligopeptide-50.8%, carnosine 1.9%, palmitoyl hexapeptide-121.0%, acetyl hexapeptide-11.0%, collagen amino acids 3.1%, nicotinamide 1.3%, soluble collagen 4.3% and anise stem cell extract 4%;
the surfactant includes: 0.3% of glyceryl caprylate and 6% of silica silylate;
the adhesive comprises: 7% of sodium carboxymethyl starch and 6% of polyethylene glycol;
the wetting agent comprises: 3.8 percent of dipropylene glycol and 0.4 percent of propylene glycol;
the antioxidant comprises: 1.1% of ascorbic acid;
the fat-soluble antioxidant comprises: 1.3 percent of natural vitamin E;
the crosslinking agent comprises: 3.8 percent of triethanolamine;
the wall material comprises: methyl methacrylate crosspolymer 9.5%;
3.9-4.5% of the antibacterial agent, wherein the antibacterial agent comprises a water-soluble antibacterial agent and a fat-soluble antibacterial agent;
the balance weight is deionized water.
Further, the water-soluble antibacterial agent is: 0.2-0.4% of caprylyl hydroximic acid, and the fat-soluble antibacterial agent is: 2.7 to 5.7 percent of p-hydroxyacetophenone and 0.2 to 0.45 percent of phenoxyethanol.
Further, the water-soluble antioxidant is 3-o-ethyl ascorbic acid.
The invention also provides a preparation method of the repairing microcapsule powder, which comprises the following steps:
(1) dissolving surfactant, water-soluble antioxidant, adhesive and water-soluble antibacterial agent in deionized water at 40-75 deg.C to obtain water phase;
(2) melting the wetting agent, the fat-soluble antioxidant, the fat-soluble antibacterial agent and the wall material in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) stirring and cooling, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, and soluble collagen, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) adding a cross-linking agent into the white fine uniform emulsion under stirring, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
Further, the water-soluble antibacterial agent is caprylhydroxamic acid, and the fat-soluble antibacterial agent is p-hydroxyacetophenone and phenoxyethanol.
Further, in the preparation method, the cross-linking agent is added into the emulsion under the condition that the rotating speed is 350 r/min.
The sea fennel has a peculiar effect on treating skin burnt by sunlight or wounds caused by other accidents, and is classified as a national treasure plant for limiting exploitation by the French population. The natural plant nutrient is a most rare maintenance component in the 21 st century due to the characteristics of manual picking, difficult growth and limited harvest. The hypecoum japonicum stem cells are powder formed by freeze drying hypecoum japonicum callus culture filtrate, and the dry matter content of the hypecoum japonicum stem cells is 92-99%. The hypecoum erectum stem cells contain the complete components of hypecoum erectum, are rich in various lipids, phenolic compounds, saccharides and polyhydroxy substances, and can regulate keratinocyte formation, promote cell proliferation, improve skin self-healing and repairing capability, improve skin hydration capability, reduce free radicals caused by UVB, improve skin luster and lighten pigmentation.
After the hypecoum hainanense stem cells are compounded with various functional peptides, a synergistic effect is generated on the aspect of skin maintenance, so that the effects of better repairing skin wounds, fading scars, inhibiting the formation of scars, protecting the skin from various injuries, effectively promoting the growth of the skin, reducing fine wrinkles and resisting aging are achieved.
The hypecoum japonicum stem cell extract can be stored only in a freeze-dried powder state, and is easy to lose activity at normal temperature. The anti-aging repairing microcapsule powder prepared by the optimized process overcomes the problem that functional peptides and the hypecoum japonicum stem cell extract are difficult to store at normal temperature.
The invention has the beneficial effects that:
1. the invention combines various functional peptides with hypecoum erectum stem cells to generate a synergistic anti-aging repairing effect.
2. In the preparation process of the repairing microcapsule powder, the water-soluble antioxidant and the fat-soluble antioxidant are respectively added into the water phase and the oil phase, so that the functional components are protected against the oxidation of the environment, the hypecol stem cell extract is not inactivated under the normal temperature condition for a long time, and the stability of the repairing microcapsule powder product is enhanced. Meanwhile, the fat-soluble antioxidant vitamin E can be combined with water-soluble carnosine to act, so that the synergistic effect is realized, free radicals are eliminated, active oxygen free radicals are quenched, cell membranes are protected, and the damage of the free radicals to organisms is prevented.
3. The repairing microcapsule powder is in a flowing white superfine powder shape, the particle size is about 3-60 mu m, and an electron microscope photo is in a granular shape. The appearance, the fluidity and the hand feeling of the product are not changed within three years after the production, and the peptide content detection value is stable.
4. The white ultrafine powder of the repairing microcapsule powder is dissolved into the floccule by pressing with hands, and the floccule is melted into cream when being applied to the face, is smooth and fine, can be quickly absorbed by the epidermis of the skin within a few seconds, and obviously improves the absorption effect.
5. The invention optimizes compatibility, takes carnosine as a core, and matches hypecoum dry cell extract, oligopeptides with different functions, rich collagen amino acids and nicotinamide as a skin anti-aging ingredient for locking water and keeping moisture, so as to furthest resist skin free radicals and saccharification injury, promote skin metabolism, stimulate cell regeneration, proliferation, collagen regeneration and elastin synthesis repair to reduce wrinkle generation on the premise of economy and effect balance. Protecting and repairing skin DNA damage caused by ultraviolet rays, enhancing skin immunity, regulating water, acid and alkali, balancing oil, improving anti-allergy ability of sensitive skin, and deeply locking water for resisting aging. The functional component composition is applied to skin medicine and skin cosmetology, is easy to be absorbed by the skin, and plays multi-target roles of scavenging free radicals, resisting oxidation, resisting glycosylation, resisting inflammation, protecting, repairing and the like, thereby fundamentally generating the effects of resisting inflammation and aging and keeping the skin in a young, beautiful and healthy state.
The physicochemical actions of the functional components in the repairing microcapsule powder of the present invention are detailed below:
carnosine is a very powerful component with antioxidant and anti-aging functions and is called a "liquid ultrasonic blade". Its other full-function is to prevent free radical damage, especially to protect the lipid components of the cell membrane, which are stabilizers and protectors of the cell membrane. If the cell membrane is damaged it is like a balloon is perforated-nothing is used. Carnosine not only protects the cell membrane, but also the mitochondrial membrane inside the cell. It can neutralize and remove free radicals that attack DNA in our cells. It can also be used as an anti-inflammatory agent to enhance the immune system.
Carnosine can chelate heavy metal ions, and adjust the concentration of copper ions, zinc ions and a plurality of metal ions, so that the copper ions, the zinc ions and the metal ions are always in effective and safe concentrations.
Carnosine is also an anti-glycation molecule. Glycation (Glycation) has long been recognized as an important factor in aging. It is known that glucose cross-linking breaks down proteins to form advanced glycation end products (AGEs), which in turn lead to more age-related diseases. In the case of skin, glycation is considered to be the main culprit for deep wrinkles, skin thinning and senile plaques, however, carnosine can be combined with carbonyl groups of proteins, so that the proteins are prevented from being adhered by sugar, cross-linking is not easy to occur, and the proteins are protected.
More interesting is the alleged extension of the Hayfick limit. The cell can self-replicate only about 52 times before 'death', and the carnosine can prolong the replication capacity of the cell for more than 60 times, so the anti-aging composition is worthy of name.
The oligopeptide-5 is an antioxidant in the skin care product, can be directly and effectively absorbed and utilized by cells, and quickly supplements collagen, thereby playing a good role in conditioning, such as promoting metabolism, stimulating cell regeneration, proliferation and collagen regeneration; the effect is slow, but the safety is high.
Palmitoyl hexapeptide-12 is mainly used for repairing, promoting angiogenesis, elastin synthesis and the like. A neurotransmitter inhibitory peptide. In the anti-wrinkle aspect, a false zone is often trapped, which is supposed to be sufficient as long as the skin is adjusted, but this is not the case. Many times, our neurotransmitters are over-released, resulting in hyperexcitability of the nerve. Excessive activation of neurotransmitters, such as choline, leads to accelerated movement of facial muscles, thus causing wrinkles. And the palmitoyl hexapeptide-12 can inhibit neurotransmitter choline, thereby reducing wrinkle generation.
Acetyl hexapeptide-1 enhances the resistance of the skin to ultraviolet rays; protecting and repairing the DNA damage caused by ultraviolet; reducing inflammatory reaction caused by ultraviolet irradiation, and reducing skin erythema. Has excellent anti-wrinkle effect and remarkable effect.
Collagen amino acids are basic components constituting collagen, and amino acids have many effects on the skin, such as delaying skin aging, anti-allergy, and the like. The amino acids can enhance skin immunity, regulate water, acid and alkali, balance oil, improve anti-allergy ability of sensitive skin, and prevent wrinkle. Remove excessive free radicals of skin cells and effectively delay skin aging. The amino acid is the minimum unit for forming protein, directly acts on the real cortical fibroblasts, obviously improves the appearance and the skin quality after being used, does not influence the barrier function of the skin, can generate chelation reaction with divalent metal ions in the skin, prevents excessive divalent metal ions from generating crosslinking action with collagen in the skin, maintains enough collagen fibers and elastic fibers, and enables the skin to be smooth, fine and rich in elasticity.
Niacinamide is a well-known skin anti-aging ingredient in the field of beauty skin science, and the most important effect in skin anti-aging is to reduce and prevent dullness, yellowing and vegetable color of skin color generated in the early aging process of skin. Niacinamide also repairs the damaged stratum corneum lipid barrier, improving skin resistance. The effect that the niacinamide is easily ignored by people is the deep water-locking effect, and the skin care product containing the niacinamide has extremely strong water-locking and moisturizing effects.
The hypecoum erectum stem cell extract is hypecoum erectum callus culture filtrate, and has effects of stimulating keratinocyte formation, promoting epidermal metabolism, improving skin self-healing ability, reducing free radical invasion, improving skin aging, improving skin moisturizing performance, reducing pigmentation, and improving skin luster.
Plant stem cells, also known as meristems, are referred to as mature tissues in plants that have differentiated to maturity. Plant meristems can be divided into two major groups, apical meristem and lateral meristem, depending on their location. Wherein the apical meristem comprises a shoot apical meristem and a root apical meristem. The lateral meristem comprises the vascular cambium and the cork cambium. In short, a plant's stem cells are two "clumps" of cells within the plant. These two clusters of cells are located in the apical meristem and root apical meristem of the plant, respectively. The hypecoum japonicum stem cell extract is a main raw material and a source spring for skin stem cell metabolism, can quickly activate dormant stem cells, promote self-repair and renewal of the stem cells, reduce the primary activity of epidermal stem cells, and regenerate the skin cell source, thereby achieving the anti-aging effects of promoting and firming the skin and fading wrinkles.
Description of the drawings:
FIG. 1: the microcapsule powder of the invention is a skin contrast chart before and after use
a is a photograph of the skin before use; b is a photograph of the skin after use.
The specific implementation mode is as follows:
the following examples are illustrative of the present invention and the present invention is not limited to the following examples.
Example 1:
weighing oligopeptide-5107 g, carnosine 169g, palmitoyl hexapeptide-12128 g, acetyl hexapeptide-1141 g, collagen amino acids 196g, nicotinamide 84g, soluble collagen 396g, and anise stem cell extract 283 g;
22g of glyceryl caprylate, 452g of silica silylate, 322g of sodium carboxymethyl starch, 424g of polyethylene glycol, 283g of dipropylene glycol, 33g of propylene glycol, 90g of 3-o-ethyl ascorbic acid, 112g of natural vitamin E, 339g of triethanolamine, 594g of methyl methacrylate cross-linked polymer, 22g of caprylyl hydroxy fatty acid, 322g of p-hydroxyacetophenone and 25g of phenoxyethanol; 1116g of deionized water;
the repairing microcapsule powder of the invention is prepared by the following steps:
(1) dissolving surfactant glyceryl caprylate and silica silylate, water-soluble antioxidant 3-O-ethyl ascorbic acid, binder carboxymethyl starch sodium and polyethylene glycol in deionized water at 40-75 deg.C to obtain water phase;
(2) melting a wetting agent dipropylene glycol, propylene glycol, a fat-soluble antioxidant natural vitamin E and a wall material methyl methacrylate cross-linked polymer in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) cooling under stirring, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, antibacterial agent octanoyl hydroxy fatty acid, p-hydroxyacetophenone, and phenoxyethanol, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) and adding a cross-linking agent into the white fine uniform emulsion under the stirring condition of the rotating speed of 350r/min, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
The invention provides a sea fennel stem cell which is produced by SEPPIC company of France and is prepared by culturing sea fennel callus by biotechnology, and the name of INCI is: crithmum MARITIMUM (Crithmum MARITIMUM) callus culture filtrate.
Example 2:
weighing oligopeptide-550 g, carnosine 80g, palmitoyl hexapeptide-1262 g, acetyl hexapeptide-167 g, collagen amino acids 94g, nicotinamide 14g, soluble collagen 188g and aniseed stem cell extract 15 g;
6g of glyceryl caprylate, 82g of silica silylate, 95g of sodium carboxymethyl starch, 122g of polyethylene glycol, 84g of dipropylene glycol, 12g of propylene glycol, 12g of 3-o-ethyl ascorbic acid, 25g of natural vitamin E, 92g of triethanolamine, 207g of methyl methacrylate cross-linked polymer, 8g of caprylyl hydroxy fatty acid, 74g of p-hydroxyacetophenone and 11g of phenoxyethanol; 1300g of deionized water;
the repairing microcapsule powder of the invention is prepared by the following steps:
(1) dissolving surfactant glyceryl caprylate and silica silylate, water-soluble antioxidant 3-O-ethyl ascorbic acid, binder carboxymethyl starch sodium and polyethylene glycol in deionized water at 40-75 deg.C to obtain water phase;
(2) melting a wetting agent dipropylene glycol, propylene glycol, a fat-soluble antioxidant natural vitamin E and a wall material methyl methacrylate cross-linked polymer in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) cooling under stirring, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, antibacterial agent octanoyl hydroxy fatty acid, p-hydroxyacetophenone, and phenoxyethanol, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) and adding a cross-linking agent into the white fine uniform emulsion under the stirring condition of the rotating speed of 350r/min, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
Example 3:
weighing oligopeptide-550 g, carnosine 100g, palmitoyl hexapeptide-1264 g, acetyl hexapeptide-182 g, collagen amino acids 162g, nicotinamide 78g, soluble collagen 242g and anise stem cell extract 102 g;
22g of glyceryl caprylate, 302g of silica silylate, 322g of sodium carboxymethyl starch, 382g of polyethylene glycol, 194g of dipropylene glycol, 32g of propylene glycol, 52g of 3-o-ethyl ascorbic acid, 54g of natural vitamin E, 192g of triethanolamine, 426g of methyl methacrylate cross-linked polymer, 20g of caprylyl hydroxy fatty acid, 160g of p-hydroxyacetophenone and 22g of phenoxyethanol; 2600g of deionized water;
the repairing microcapsule powder of the invention is prepared by the following steps:
(1) dissolving surfactant glyceryl caprylate and silica silylate, water-soluble antioxidant 3-O-ethyl ascorbic acid, binder carboxymethyl starch sodium and polyethylene glycol in deionized water at 40-75 deg.C to obtain water phase;
(2) melting a wetting agent dipropylene glycol, propylene glycol, a fat-soluble antioxidant natural vitamin E and a wall material methyl methacrylate cross-linked polymer in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) cooling under stirring, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, antibacterial agent octanoyl hydroxy fatty acid, p-hydroxyacetophenone, and phenoxyethanol, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) and adding a cross-linking agent into the white fine uniform emulsion under the stirring condition of the rotating speed of 350r/min, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
Example 4:
weighing 555 g of oligopeptide, 108g of carnosine, 1272 g of palmitoyl hexapeptide, 196g of acetyl hexapeptide, 171g of collagen amino acids, 82g of nicotinamide, 250g of soluble collagen and 112g of anise stem cell extract;
21g of glyceryl caprylate, 311g of silica silylate, 332g of sodium carboxymethyl starch, 391g of polyethylene glycol, 203g of dipropylene glycol, 34g of propylene glycol, 58g of 3-o-ethyl ascorbic acid, 59g of natural vitamin E, 201g of triethanolamine, 430g of methyl methacrylate cross-linked polymer, 22g of caprylyl hydroxy fatty acid, 170g of p-hydroxyacetophenone and 24g of phenoxyethanol; 2516g of deionized water;
the repairing microcapsule powder of the invention is prepared by the following steps:
(1) dissolving surfactant glyceryl caprylate and silica silylate, water-soluble antioxidant 3-O-ethyl ascorbic acid, binder carboxymethyl starch sodium and polyethylene glycol in deionized water at 40-75 deg.C to obtain water phase;
(2) melting a wetting agent dipropylene glycol, propylene glycol, a fat-soluble antioxidant natural vitamin E and a wall material methyl methacrylate cross-linked polymer in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) cooling under stirring, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, antibacterial agent octanoyl hydroxy fatty acid, p-hydroxyacetophenone, and phenoxyethanol, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) and adding a cross-linking agent into the white fine uniform emulsion under the stirring condition of the rotating speed of 350r/min, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
Example 5:
weighing oligopeptide-516 g, carnosine 38g, palmitoyl hexapeptide-1221 g, acetyl hexapeptide-119 g, collagen amino acids 61g, nicotinamide 25g, soluble collagen 86g and anise stem cell extract 30 g;
5g of glyceryl caprylate, 120g of silica silylate, 140g of sodium carboxymethyl starch, 120g of polyethylene glycol, 76g of dipropylene glycol, 10g of propylene glycol, 21g of 3-o-ethyl ascorbic acid, 19g of natural vitamin, 80g of triethanolamine, 190g of methyl methacrylate cross-linked polymer, 6g of caprylyl hydroxy fatty acid, 65g of p-hydroxyacetophenone and 8g of phenoxyethanol; 1150g of deionized water;
the repairing microcapsule powder of the invention is prepared by the following steps:
(1) dissolving surfactant glyceryl caprylate and silica silylate, water-soluble antioxidant 3-O-ethyl ascorbic acid, binder carboxymethyl starch sodium and polyethylene glycol in deionized water at 40-75 deg.C to obtain water phase;
(2) melting a wetting agent dipropylene glycol, propylene glycol, a fat-soluble antioxidant natural vitamin E and a wall material methyl methacrylate cross-linked polymer in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) cooling under stirring, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen, antibacterial agent octanoyl hydroxy fatty acid, p-hydroxyacetophenone, and phenoxyethanol, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) and adding a cross-linking agent into the white fine uniform emulsion under the stirring condition of the rotating speed of 350r/min, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
The first test example: stability test
Selecting the repairing microcapsule powder prepared in the examples 1-5 as a test sample, and measuring the polypeptide content, the moisture content, the total number of bacterial colonies, the coliform group, pathogenic bacteria (salmonella, staphylococcus aureus, shigella, hemolytic streptococcus), mold, yeast and various indexes thereof respectively in the month of preparation, 6 months, 12 months and 18 months after preparation; the results are given in tables 1, 2, 3, 4 below. (determination of the polypeptide content in the sample by peptide bond assay)
TABLE 1
TABLE 2
TABLE 3
TABLE 4
The detection result shows that the active polypeptide as the effective component of the repairing microcapsule powder has stable content after being stored for 1-18 months, and has no obvious difference after t value detection;
the moisture content has no obvious difference;
the colony detection reaches the standard.
Test example two: skin care test
And (3) wrinkle fading effect:
the repairing microcapsule powder is tried by 60 people for 40 days. The age is 30-55 years. The 60 people all had different degrees of wrinkles on their faces and the facial complexion was darker.
The using method comprises the following steps: the external application is carried out for 2 times every day, and the dosage is that the face is evenly applied.
After 40 days of use the skin began to become moisturized, smooth, and restored luster and elasticity, with 49 (82%) consumers feeling a noticeable reduction in crow's feet and 37 (62%) consumers feeling a noticeable reduction in wrinkles, as shown in figure 1.
The effective rate statistics of the fishtail line fading and wrinkle fading of the microcapsule powder prepared according to the embodiments of the invention are shown in table 5:
table 5:
test example three: effect of vitamin E on stability of the microcapsule powder:
in a constant temperature environment of 40 ℃, experimental groups 3, 4: the microcapsule powders prepared in examples 3 and 4 were mixed with comparative groups 5, 6: the peptide content of the microcapsule powders prepared for the removal of the vitamin E component in examples 3 and 4, respectively, was compared with time. (see Table 6)
Table 6:
although the present invention has been described in detail with reference to the above embodiments, those skilled in the art can make modifications and equivalents to the embodiments of the present invention without departing from the spirit and scope of the present invention, which is set forth in the claims of the present application.
Claims (8)
1. An anti-aging repairing microcapsule powder prepared from functional peptide composite hypecoum hainanense stem cells is characterized by comprising the following components in parts by weight: functional components, surfactant, adhesive, wetting agent, antioxidant, cross-linking agent, wall material, antibacterial agent and deionized water;
the functional components comprise, by weight of 100%: oligopeptide-50.6-1.9%, carnosine 0.9-3.0%, palmitoyl hexapeptide-120.7-2.3%, acetyl hexapeptide-10.8-2.5%, collagen amino acids 0.6-3.5%, nicotinamide 0.5-1.5%, soluble collagen 2.5-7% and anise dry cell extract 0.5% -5%;
the surfactant includes: 0.2-0.4% of glyceryl caprylate and 3% -8% of silica silylate;
the adhesive comprises: 3.5 to 9 percent of sodium carboxymethyl starch and 4.5 to 7.5 percent of polyethylene glycol;
the wetting agent comprises: 3.1 to 5 percent of dipropylene glycol and 0.4 to 0.6 percent of propylene glycol;
the water-soluble antioxidant is: ascorbic acid 0.4-1.6%;
the fat-soluble antioxidant is: 0.01-2% of natural vitamin E;
the cross-linking agent: 3.3 to 6 percent of triethanolamine;
the wall material is as follows: 4.5% -10.5% of methyl methacrylate cross-linked polymer;
3.1-6.55% of antibacterial agent, which comprises water-soluble antibacterial agent and fat-soluble antibacterial agent;
the balance weight is deionized water.
2. The repairing microcapsule powder according to claim 1,
the functional components comprise, by weight of 100%: oligopeptide-50.7-1.3%, carnosine 1.0-2.3%, palmitoyl hexapeptide-120.9-2.1%, acetyl hexapeptide-10.9-1.7%, collagen amino acids 2.0-3.2%, nicotinamide 0.7-1.3%, soluble collagen 3.5-6% and anise dry cell extract 1.1% -4.6%;
the surfactant includes: 0.2-0.3% of glyceryl caprylate and 3.5% -6.5% of silica silylate;
the adhesive comprises: 4.5 to 7.5 percent of sodium carboxymethyl starch and 5 to 6.5 percent of polyethylene glycol;
the wetting agent comprises: 3.4 to 4.3 percent of dipropylene glycol and 0.35 to 0.45 percent of propylene glycol;
the water-soluble antioxidant is: ascorbic acid 0.7-1.3%;
the fat-soluble antioxidant comprises: natural vitamin E0.08-1.6%;
the cross-linking agent is: 3.4 to 5.5 percent of triethanolamine;
the wall material is as follows: 7.5% -10% of methyl methacrylate cross-linked polymer;
3.5-5.0% of antibacterial agent, wherein the antibacterial agent comprises water-soluble antibacterial agent and fat-soluble antibacterial agent;
the balance weight is deionized water.
3. The repairing microcapsule powder according to claim 1,
the functional components comprise, by weight of 100%: oligopeptide-50.8%, carnosine 1.9%, palmitoyl hexapeptide-121.0%, acetyl hexapeptide-11.0%, collagen amino acids 3.1%, nicotinamide 1.3%, soluble collagen 4.3% and anise stem cell extract 4%;
the surfactant includes: 0.3% of glyceryl caprylate and 6% of silica silylate;
the adhesive comprises: 7% of sodium carboxymethyl starch and 6% of polyethylene glycol;
the wetting agent comprises: 3.8 percent of dipropylene glycol and 0.4 percent of propylene glycol;
the antioxidant comprises: 1.1% of ascorbic acid;
the fat-soluble antioxidant comprises: 1.3 percent of natural vitamin E;
the crosslinking agent comprises: 3.8 percent of triethanolamine;
the wall material comprises: methyl methacrylate crosspolymer 9.5%;
3.9-4.5% of the antibacterial agent, wherein the antibacterial agent comprises a water-soluble antibacterial agent and a fat-soluble antibacterial agent;
the balance weight is deionized water.
4. The repair microcapsule powder according to claim 1, wherein the water-soluble antibacterial agent is: 0.2-0.4% of caprylyl hydroximic acid, and the fat-soluble antibacterial agent is: 2.7 to 5.7 percent of p-hydroxyacetophenone and 0.2 to 0.45 percent of phenoxyethanol.
5. The repair microcapsule powder according to claim 1, wherein the water-soluble antioxidant is 3-o-ethyl ascorbic acid.
6. A method for preparing a repairing microcapsule powder according to claim 1, comprising: (1) dissolving surfactant, water-soluble antioxidant and adhesive in deionized water at 40-75 deg.C to obtain water phase;
(2) melting the wetting agent, the fat-soluble antioxidant and the wall material in a water bath at 45-70 ℃ to obtain an oil phase;
(3) controlling the rotation speed to 13000-25000r/min in a homogenizer, mixing and homogenizing the obtained oil phase and the water phase for 2-3min, and then carrying out high-pressure homogenization treatment to obtain an emulsion;
(4) stirring and cooling, cooling to 40 deg.C, adding oligopeptide-5, carnosine, palmitoyl hexapeptide-12, acetyl hexapeptide-1, collagen amino acids, nicotinamide, soluble collagen and antibacterial agent, stirring, cooling to 35 deg.C, adding dry cell of fructus Anisi Stellati to obtain white fine uniform emulsion,
(5) adding a cross-linking agent into the white fine uniform emulsion under stirring, controlling the temperature to be 30-75 ℃, carrying out stirring reaction for 4-8h, and then carrying out spray drying to obtain the repairing microcapsule powder.
7. The method for preparing a repairing microcapsule powder according to claim 6, wherein the water-soluble antibacterial agent is caprylhydroxamic acid, and the fat-soluble antibacterial agent is p-hydroxyacetophenone and phenoxyethanol.
8. The process for preparing a repairing microcapsule powder according to claim 6, wherein in the process, the emulsion is stirred at a rotation speed of 350r/min with the addition of the crosslinking agent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115350138A (en) * | 2022-08-29 | 2022-11-18 | 嘉仕汇(上海)生物科技有限公司 | Sea fennel plant cell-wrapped combined repairing agent and preparation method and application thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101536967A (en) * | 2009-04-22 | 2009-09-23 | 烟台新时代健康产业日化有限公司 | Green plum-blossom extraction method, new application of green plum-blossom and green plum-blossom anti-aging skin cream |
| CN102670438A (en) * | 2012-04-25 | 2012-09-19 | 珠海市时代经典化妆品有限公司 | Anti-ageing skincare product and preparation method thereof |
| CN104873412A (en) * | 2015-05-04 | 2015-09-02 | 上海应用技术学院 | Methyl methacrylate cross-linked polymer microparticle loaded with lipid-soluble sun-screening agent and preparation method of microparticle |
| CN104892825A (en) * | 2015-05-04 | 2015-09-09 | 上海应用技术学院 | Lavender essential oil-loaded methyl methacrylate cross-linked polymer particles and preparation method thereof |
| CN106214535A (en) * | 2016-07-29 | 2016-12-14 | 广州市创美时美容化妆品有限公司 | A kind of can the anti-apolexis composition of activating cell containing sponge micropin |
| CN109223660A (en) * | 2018-11-22 | 2019-01-18 | 武汉跃莱健康产业有限公司 | A kind of shining face is anti-ageing to peptide face cream and preparation method thereof |
| CN109875950A (en) * | 2019-03-21 | 2019-06-14 | 珠海金肽生物科技有限公司 | A kind of composition of the filtrate of culture containing plant callus and its application |
| US20190336429A1 (en) * | 2017-12-29 | 2019-11-07 | Basf Corporation | Synergistic tetrapeptide combination |
| CN111035609A (en) * | 2020-01-10 | 2020-04-21 | 上海赵小蝶化妆品有限公司 | Micromolecular polypeptide eye essence and preparation method thereof |
-
2020
- 2020-10-29 CN CN202011185868.5A patent/CN112190535A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101536967A (en) * | 2009-04-22 | 2009-09-23 | 烟台新时代健康产业日化有限公司 | Green plum-blossom extraction method, new application of green plum-blossom and green plum-blossom anti-aging skin cream |
| CN102670438A (en) * | 2012-04-25 | 2012-09-19 | 珠海市时代经典化妆品有限公司 | Anti-ageing skincare product and preparation method thereof |
| CN104873412A (en) * | 2015-05-04 | 2015-09-02 | 上海应用技术学院 | Methyl methacrylate cross-linked polymer microparticle loaded with lipid-soluble sun-screening agent and preparation method of microparticle |
| CN104892825A (en) * | 2015-05-04 | 2015-09-09 | 上海应用技术学院 | Lavender essential oil-loaded methyl methacrylate cross-linked polymer particles and preparation method thereof |
| CN106214535A (en) * | 2016-07-29 | 2016-12-14 | 广州市创美时美容化妆品有限公司 | A kind of can the anti-apolexis composition of activating cell containing sponge micropin |
| US20190336429A1 (en) * | 2017-12-29 | 2019-11-07 | Basf Corporation | Synergistic tetrapeptide combination |
| CN109223660A (en) * | 2018-11-22 | 2019-01-18 | 武汉跃莱健康产业有限公司 | A kind of shining face is anti-ageing to peptide face cream and preparation method thereof |
| CN109875950A (en) * | 2019-03-21 | 2019-06-14 | 珠海金肽生物科技有限公司 | A kind of composition of the filtrate of culture containing plant callus and its application |
| CN111035609A (en) * | 2020-01-10 | 2020-04-21 | 上海赵小蝶化妆品有限公司 | Micromolecular polypeptide eye essence and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115350138A (en) * | 2022-08-29 | 2022-11-18 | 嘉仕汇(上海)生物科技有限公司 | Sea fennel plant cell-wrapped combined repairing agent and preparation method and application thereof |
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