CN107951769A - Anti-aging face cream and preparation method and application thereof - Google Patents
Anti-aging face cream and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention belongs to the field of skin care products, and particularly relates to anti-aging face cream as well as a preparation method and application thereof. The anti-aging cream is characterized by comprising the following components in percentage by mass: 0.03-0.06% of epidermal cell growth factor; 10.05 to 0.1 percent of dipeptide; palmitoyl pentapeptide-40.05-0.08%; 3-5% of grapefruit extract; 1-2% of lemon extract; 15-20% of a humectant; 2-4% of a thickening agent; 0.5-1% of an emulsifier; 0.01-0.03% of antioxidant; 0.1-0.2% of preservative; water makes up to 100%. The anti-aging cream provided by the invention contains a plurality of active peptides, and can promote the metabolism of various cells of the skin and enhance the absorption of nutrient substances by the cells. Promoting synthesis of collagen and collagenase, secreting collagen substances, hyaluronic acid and glycoprotein, regulating collagen fiber, moistening skin, improving skin elasticity, reducing skin wrinkle and preventing skin aging.
Description
Technical field
The invention belongs to skin care field, and in particular to a kind of anti-aging face cream and preparation method and application.
Background technology
Skin is area maximum, the human organ of most significant, has the barrier function for resisting extraneous various chemical factors,
And one of important indication of reflection organism aging process.And the related sign of skin aging is the characteristic change of a series of complex or faces
Bed performance：The regression of existing skin texture, there is also the decline of skin barrier function or physiology relevant parameter, or even meeting
There are the related skin complaints because of caused by aging.
Skin aging be by complicated phenomenon that is gene-determined, persistently changing with the age, it is including extrinsic aging and interior
The aging of source property.Intrinsic aging is also known as natural aging, is the endogenic program process determined by individual inheritance background, with the time
Passage gradually forms.It is extrinsic aging mainly related with the cumulative bad infringement that the extraneous factors such as ultraviolet radiation produce, and accelerate
Natural aging process.But.No matter endogenous or exogenous, its skin aging all concentrates on：Wrinkle, relaxation, elasticity
Forfeiture, coarse, pigmentation or exception, atrophoderma, telangiectasis.
With the progress of astogeny society, the feature and prevention for studying person in middle and old age's skin become skin with delay skin aging
The important hot spot in section field, and require the effect of cosmetics safety and consumer step up for cosmetics to promote anti-aging
The continuous development and raising of cosmetics research and development technology.Product senile-resistant efficacy approach also repairs the barrier of skin from single moisturizing
Function, has progressively derived more multipath：Promote cell metabolism；Supplement and the production for promoting self collagen albumen and elastin laminin
It is raw；It is anti-oxidant；It is sun-proof；Skin immune system is repaired, improves defence capability；DNA plerosis damage；The overreaction of nerve is reduced,
Desalinate wrinkle.More and more research staff recognize to develop the suppression that can more have for the joint product of a variety of anti-aging approach
The process of skin aging, then the development trend of anti-aging product evolve as a variety of anti-aging strategies integrated application, from
Aging is resisted to pre- anti-aging, the following research for having the basic subjects such as more dermatologies, chemistry, biology, bionics, physics
Achievement will be applied in anti-aging cosmetics research and development.
The content of the invention
For overcome the deficiencies in the prior art and shortcoming, primary and foremost purpose of the invention is to provide a kind of anti-aging face cream.
Another object of the present invention is to provide a kind of preparation method of above-mentioned anti-aging face cream.
It is still another object of the present invention to provide a kind of above-mentioned application of anti-aging face cream.
The purpose of the present invention is achieved through the following technical solutions：
A kind of anti-aging face cream, includes component as follows by mass percentage：
The anti-aging face cream, preferably comprises following component by mass percentage：
The moisturizer is preferably glycerine, caprylic/capric triglyceride, isononyl isononanoate, dimethyl silicone polymer
Mixture；
The glycerine, caprylic/capric triglyceride, isononyl isononanoate, the mass ratio of dimethyl silicone polymer are preferred
For (5~8)：(3~5)：1:1；
The thickener is preferably cellulose thickener and at least one of natural gum and its modifier；
The cellulose thickener is preferably carboxymethyl hydroxyethyl cellulose, spermaceti hydroxyethyl cellulose, ethyl fibre
Tie up in element, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methylcellulose, carboxymethyl cellulose extremely
Few one kind；
The natural gum and its modifier is preferably alginic acid and its (ammonium, calcium, potassium, sodium) salt, pectin, hyaluronic acid
Sodium, guar gum, cation guar gum, hydroxypropyl guar gum, bassora gum, antler glue and its (calcium, sodium) salt, xanthan gum and sclerotium
At least one of glue；
The thickener is more preferably the mixture of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum；
The mass ratio of the carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum is preferably：1:2:1；
The emulsifying agent is preferably methyl sesquistearate, PEG-20 methyls sesquistearate, sweet
At least one of oleostearin acid esters and PEG-100 stearates；
The antioxidant is preferably vitamine C palmitate；
The preservative be preferably in sodium benzoate, methylisothiazolinone, propylben/butyl ester and Kathon CG extremely
Few one kind；
The preparation method of the anti-aging face cream, comprises the following steps：
(1) the component moisturizer of anti-aging face cream, emulsifying agent and preservative are added in oil phase pot, in 60~80 DEG C of bar
Stirred under part, be uniformly mixed each component, obtain mixture 1；
(2) the component thickener, antioxidant and water of anti-aging face cream are added in water phase pot, in 60~80 DEG C of condition
Lower stirring, is uniformly mixed each component, obtains mixture 2；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient of anti-aging face cream is added, is stirred evenly, obtains anti-aging face cream；
The principle of the present invention：
Epithelical cell growth factor energy intense stimulus cell growth, suppresses aging gene expression, prevents skin senescence, make skin
Skin each group composition keeps optimal physiological status.In addition, it can also stimulate extracellular some macromolecular (such as hyaluronic acids and collagen egg
It is white etc.) synthesis and secretion, skin care, is the key factor for determining skin vitality and health.Dipeptides -1 is by 2 amino acid institutes
Into can resist skin edema, make skin consolidation, flexible.Matrixyl -4 can penetrate corium stimulation collagen, elastic force
Fiber and hyaluronic acid hyperplasia, improve the water content and water lock degree of skin, increase skin thickness and reduce microgroove, by from interior
Carry out the process of reversing skin aging to outer rebuilding.Grape fruit extract can nurse tissue cell, the anti-sense of inducing diuresis to remove edema, antibacterial
Dye, treatment pore are thick, the skin of the easy long small pox such as conditioning mixed type, oiliness；Deep layer purifies oiliness dark sore and congested skin
Skin, Rosemary Extract is with tissue, its component aurantiin has the radical chain reaction for blocking mouse thymus cells, i.e. naringin has anti-
Oxidisability acts on.Lemon extract main component has limonene (up to 90%), citral, octanal, aldehyde C-9, capraldehyde, lauric aldehyde, pinane
Alkene, amphene, linalool, bergamio, geranyl acetate and neryl acetate etc., can prevent pigmentation, have antibacterial, U.S.
In vain, convergence and other effects.
The present invention is had the following advantages relative to the prior art and effect：
(1) anti-aging face cream peptide containing various active provided by the invention, can promote the metabolism of the various cells of skin, increase
Strong cell absorbs nutriment.Promote collagen and collagen enzymatic synthesis, secretion Collagen material, hyaluronic acid and glycoprotein, adjust glue
Fibrillation, has skin care, enhancing skin elasticity, reduces wrinkle of skin and prevents the effect of skin senescence.
(2) present invention compounds active peptide and vegetable active extract grape fruit extract and lemon extract, has association
Same facilitation, permeable skin depths, balance skin fat secretion, improves skin elasticity, reduces wrinkle of skin, has notable
Antioxidation.
(3) present invention uses vitamine C palmitate as antioxidant, and with emulsification and bacteriostasis, while with
Grape fruit extract and lemon extract compounding, antioxidant effect enhancing, has and removes the effect such as free radical, whitening.
(4) present invention uses carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum as thickener, while to skin
With conditioning, moisturizing, moisten effect.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Grape fruit extract (product specification in embodiment：10：1) Shaanxi Hao Yang bio tech ltd, lemon are purchased from
Extract (product specification：10：1) it is purchased from Xi'an Yuan Sen bio tech ltd；
Embodiment 1
A kind of anti-aging face cream, includes component as follows by mass percentage：
The preparation method of the anti-aging face cream, comprises the following steps：
(1) by component moisturizer (glycerine, caprylic/capric triglyceride, isononyl isononanoate, poly- two of anti-aging face cream
Methylsiloxane, mass ratio 6:3.4:1:1), emulsifying agent (methyl sesquistearate and stearine, quality
Than for 1:2) add in oil phase pot with preservative methylisothiazolinone, stirred under conditions of 70 DEG C, make each component mixing equal
It is even, obtain mixture 1；
(2) by the component thickener (quality of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum of anti-aging face cream
Than for 1:2:1), antioxidant vitamin C palmitates and water are added in water phase pot, are stirred under conditions of 70 DEG C, are made each group
Divide and be uniformly mixed, obtain mixture 2；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient of anti-aging face cream is added, is stirred evenly, obtains anti-aging face cream.
Embodiment 2
A kind of anti-aging face cream, includes component as follows by mass percentage：
The preparation method of the anti-aging face cream, comprises the following steps：
(1) by component moisturizer (glycerine, caprylic/capric triglyceride, isononyl isononanoate, poly- two of anti-aging face cream
Methylsiloxane, mass ratio 8:3:1:1), emulsifier glycerol stearate and preservative methylisothiazolinone add oil phase
In pot, stirred under conditions of 60 DEG C, be uniformly mixed each component, obtain mixture 1；
(2) by the component thickener (quality of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum of anti-aging face cream
Than for 1:2:1), antioxidant vitamin C palmitates and water are added in water phase pot, are stirred under conditions of 60 DEG C, are made each group
Divide and be uniformly mixed, obtain mixture 2；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient of anti-aging face cream is added, is stirred evenly, obtains anti-aging face cream；
Embodiment 3
A kind of anti-aging face cream, includes component as follows by mass percentage：
The preparation method of the anti-aging face cream, comprises the following steps：
(1) by component moisturizer (glycerine, caprylic/capric triglyceride, isononyl isononanoate, poly- two of anti-aging face cream
Methylsiloxane, mass ratio 5:5:1:1), emulsifying agent methyl sesquistearate and preservative methylisothiazolinone
Add in oil phase pot, stirred under conditions of 80 DEG C, be uniformly mixed each component, obtain mixture 1；
(2) by the component thickener (quality of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum of anti-aging face cream
Than for 1:2:1), antioxidant vitamin C palmitates and water are added in water phase pot, are stirred under conditions of 80 DEG C, are made each group
Divide and be uniformly mixed, obtain mixture 2；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient of anti-aging face cream is added, is stirred evenly, obtains anti-aging face cream.
Comparative example 1
A kind of face cream, includes component as follows by mass percentage：
The preparation method of the face cream, comprises the following steps：
(1) by component moisturizer (glycerine, caprylic/capric triglyceride, isononyl isononanoate, the poly dimethyl silicon of face cream
Oxygen alkane, mass ratio 6:3.4:1:1), emulsifying agent (methyl sesquistearate and stearine, mass ratio 1:
2) added with preservative methylisothiazolinone in oil phase pot, stirred under conditions of 70 DEG C, be uniformly mixed each component, obtained
Mixture 1；
(2) by the component thickener of face cream, (mass ratio of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum is 1:
2:1), antioxidant vitamin C palmitates and water are added in water phase pot, are stirred under conditions of 70 DEG C, are mixed each component
Uniformly, mixture 2 is obtained；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient (epithelical cell growth factor, dipeptides -1 and Matrixyl -4) of face cream is added, stirs evenly, obtains
Face cream.
Comparative example 2
A kind of face cream, includes component as follows by mass percentage：
The preparation method of the face cream, comprises the following steps：
(1) by component moisturizer (glycerine, caprylic/capric triglyceride, isononyl isononanoate, the poly dimethyl silicon of face cream
Oxygen alkane, mass ratio 6:3.4:1:1), emulsifying agent (methyl sesquistearate and stearine, mass ratio 1:
2) added with preservative methylisothiazolinone in oil phase pot, stirred under conditions of 70 DEG C, be uniformly mixed each component, obtained
Mixture 1；
(2) by the component thickener of face cream, (mass ratio of carboxymethyl hydroxyethyl cellulose, sodium alginate and bassora gum is 1:
2:1), antioxidant vitamin C palmitates and water are added in water phase pot, are stirred under conditions of 70 DEG C, are mixed each component
Uniformly, mixture 2 is obtained；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then 37 DEG C are cooled to
Hereinafter, the remaining ingredient (grape fruit extract and lemon extract) of face cream is added, stirs evenly, obtains face cream.
Effect example
(1) 50 people of female volunteers, age bracket 30~50 years old are selected.Subject did not applied in nearly 2 months in test position
Smear any skin care item.Test temperature is 25 DEG C, humidity 40%~50%.Before test, subject is unified to clean forearm with clear water
Inner side, and carry out measurement markers.Test area interval 1cm, it is 3cm × 3cm often to locate test area, by 2mg/cm2Dosage claim
Skin care item are taken, are uniformly applied to skin care item in trial zone using latex finger cot, 15min are waited, using 750 skin tests of MC
Instrument (connection moisture measurement probe (Corneometer CM 825) and elastic fibrous tissue's test probe (MPA 580)) measures
Subject uses (0 week, 2 weeks, 4 weeks and 8 weeks) recipient site keratoderma water content and skin elasticity situation (skin before and after face cream
Skin elastic parameter R2), so as to evaluate its moisturizing senile-resistant efficacy.
(1) keratoderma moisture content
As shown in table 1, keratoderma can be made using face cream made from embodiment 1~3 and comparative example 1~2
Water content increase, but, increased significantly using keratoderma water content after face cream made from embodiment 1~3, especially embodiment
1。
1 keratoderma water content interpretation of result of table
| Embodiment | 0 week (%) | 2 weeks (%) | 4 weeks (%) | 8 weeks (%) |
| Embodiment 1 | 25.6% | 35.8% | 45.8% | 55.6% |
| Embodiment 2 | 27.4% | 36.9% | 45.2% | 53.9% |
| Embodiment 3 | 26.8% | 34.2% | 43.3% | 50.5% |
| Comparative example 1 | 26.5% | 33.4% | 37.7% | 45.8% |
| Comparative example 2 | 27.9% | 33.1% | 35.7% | 41.6% |
(2) skin elasticity situation
As shown in table 2, it can increase skin elasticity using face cream made from embodiment 1~3 and comparative example 1~2
Add, but, increased significantly using skin elasticity after face cream made from embodiment 1~3, especially embodiment 1.
2 skin elasticity situation interpretation of result of table
| Embodiment | 0 week (R2) | 2 weeks (R2) | 4 weeks (R2) | 8 weeks (R2) |
| Embodiment 1 | 0.43 | 0.68 | 0.78 | 0.81 |
| Embodiment 2 | 0.41 | 0.61 | 0.75 | 0.78 |
| Embodiment 3 | 0.45 | 0.71 | 0.79 | 0.80 |
| Comparative example 1 | 0.43 | 0.50 | 0.58 | 0.61 |
| Comparative example 2 | 0.41 | 0.45 | 0.51 | 0.55 |
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of anti-aging face cream, it is characterised in that include component as follows by mass percentage：
2. anti-aging face cream according to claim 1, it is characterised in that include component as follows by mass percentage：
3. anti-aging face cream according to claim 1 or 2, it is characterised in that：
The moisturizer is glycerine, caprylic/capric triglyceride, isononyl isononanoate, the mixture of dimethyl silicone polymer.
4. anti-aging face cream according to claim 3, it is characterised in that：
The glycerine, caprylic/capric triglyceride, isononyl isononanoate, the mass ratio of dimethyl silicone polymer are (5~8)：
(3~5)：1:1.
5. anti-aging face cream according to claim 1 or 2, it is characterised in that：
The thickener is cellulose thickener and at least one of natural gum and its modifier.
6. anti-aging face cream according to claim 5, it is characterised in that：
The cellulose thickener is carboxymethyl hydroxyethyl cellulose, spermaceti hydroxyethyl cellulose, ethyl cellulose, hydroxyl second
At least one of base cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methylcellulose, carboxymethyl cellulose；
The natural gum and its modifier are alginic acid and its salt, pectin, Sodium Hyaluronate, guar gum, cation guar gum,
At least one of hydroxypropyl guar gum, bassora gum, antler glue and its salt, xanthan gum and sclerotium gum.
7. anti-aging face cream according to claim 1 or 2, it is characterised in that：
The emulsifying agent is methyl sesquistearate, PEG-20 methyls sesquistearate, glycerol stearate
At least one of ester and PEG-100 stearates.
8. anti-aging face cream according to claim 1 or 2, it is characterised in that：
The antioxidant is vitamine C palmitate.
9. anti-aging face cream according to claim 1 or 2, it is characterised in that：
The preservative is sodium benzoate, methylisothiazolinone, propylben/at least one of butyl ester and Kathon CG.
10. the preparation method of claim 1~9 any one of them anti-aging face cream, it is characterised in that comprise the following steps：
(1) the component moisturizer of anti-aging face cream, emulsifying agent and preservative are added in oil phase pot, under conditions of 60~80 DEG C
Stirring, is uniformly mixed each component, obtains mixture 1；
(2) the component thickener, antioxidant and water of anti-aging face cream are added in water phase pot, is stirred under conditions of 60~80 DEG C
Mix, be uniformly mixed each component, obtain mixture 2；
(3) mixture 1 is slowly added in mixture 2, it is stirring while adding, make its emulsification uniform；Then less than 37 DEG C are cooled to,
The remaining ingredient of anti-aging face cream is added, stirs evenly, obtains anti-aging face cream.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108743921A (en) * | 2018-05-24 | 2018-11-06 | 广州芬森医学科技有限公司 | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed |
| CN110638718A (en) * | 2019-10-25 | 2020-01-03 | 广东密尚生物科技有限公司 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
| CN111000738A (en) * | 2020-01-03 | 2020-04-14 | 北京幸福益生再生医学科技有限公司 | Anti-aging cosmetic and preparation method thereof |
| CN113116762A (en) * | 2019-12-30 | 2021-07-16 | 广州市科能化妆品科研有限公司 | Firming cream, preparation method thereof and collagenase inhibitor |
| CN113143783A (en) * | 2021-01-22 | 2021-07-23 | 辉达生物医药（苏州）有限公司 | Anti-aging composition |
| CN114533584A (en) * | 2022-04-21 | 2022-05-27 | 加来(济南)生活科技有限公司 | Collagenase anti-wrinkle face cream |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108743921A (en) * | 2018-05-24 | 2018-11-06 | 广州芬森医学科技有限公司 | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed |
| CN110638718A (en) * | 2019-10-25 | 2020-01-03 | 广东密尚生物科技有限公司 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
| CN110638718B (en) * | 2019-10-25 | 2022-06-24 | 厦门孝恩颜究室医疗科技有限公司 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
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| CN113143783A (en) * | 2021-01-22 | 2021-07-23 | 辉达生物医药（苏州）有限公司 | Anti-aging composition |
| CN114533584A (en) * | 2022-04-21 | 2022-05-27 | 加来(济南)生活科技有限公司 | Collagenase anti-wrinkle face cream |
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