CN109528543A - One kind repairing sensitive skin lotion and preparation method thereof based on private gene customization - Google Patents
One kind repairing sensitive skin lotion and preparation method thereof based on private gene customization Download PDFInfo
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- CN109528543A CN109528543A CN201811574880.8A CN201811574880A CN109528543A CN 109528543 A CN109528543 A CN 109528543A CN 201811574880 A CN201811574880 A CN 201811574880A CN 109528543 A CN109528543 A CN 109528543A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- Cosmetics (AREA)
Abstract
The invention discloses one kind to repair sensitive skin lotion and preparation method thereof based on private gene customization, it is related to technical field of skin care, solve technical problem is how to improve the reparation barrier function of skin, it is safer to use to resist environmental stimuli, the skin lotion carries out raw material proportioning according to private genetic test, it is made of following components parts by weight: 2~8 parts of emulsifier, 5~30 parts of emollient, 5~20 parts of moisturizer, 0.1~5 part of thickener, 0.5~1 part of preservative, 1~30 part of fibronectin, 0.05~2 part of dipotassium glycyrrhizinate, 0.1~3 part of antioxidant, 0.1~2 part of pH adjusting agent, 30~85 parts of solvent.Product of the present invention has the reparation barrier function for improving skin, resists environmental stimuli, uses safer effect.
Description
Technical field
The present invention relates to technical field of skin care, more particularly to a kind of customized based on private gene to repair sensitive skin lotion
And preparation method thereof.
Background technique
Sensitive is a kind of problem skin, and domestic female sensitive skin accounts about sixty percent as sensitive skin, leads
The root of sensitization perception skin is exactly that skin barrier function is impaired.General sensitivity skin seems that skin can be relatively thin, does not tolerate, holds
Easy allergy, red capillary on the face is obvious, and often skin be easy it is general red.Sensitive is easy by environmental factor, seasonal variations
And skin care item stimulation, many consumers are due to having used the cosmetics of steroids to cause to become sensitive skin, sensitivity
The consumer of skin is for the more demanding of skin care item.
The basic reason for causing sensitive skin is mainly the impaired immunity degradation for causing skin of Skin Cell, and cuticula becomes
Thin to cause skin moisturizing degree inadequate, the reparation barrier function for eventually leading to skin is excessively weak, can not resist environmental stimuli.Work as skin
, will be excessively excited when the nerve fibre of skin is by extraneous stimulation for a long time, therefore it is easy to produce general red, itch, shouting pain, it generates heat
Deng uncomfortable phenomenon.
The object that skin care item are directed to currently on the market is all to meet most people can be used, for a small number of specific crowds or
Personal using effect is bad, and most consumers are all blindness skin care, blindly waits for information advertisement and declares without combining itself
Situation selects proper product, or the skin of oneself is taken to remove examination new product always, spends a large amount of time, after money and energy
But it produces little effect, even results in skin and come to harm.Some high-end consumer groups even individual is intended to obtain a for certainly
Oneself cutaneous gene and the skin-protection product that developed customize skin-protection product according to private gene and carry out accurate skin care concept gradually
It rises.
This invention uses with private gene the theory for customizing skin-protection product, according to different application on human skin genetic test reports
Situation, season, age, the dimension scientific design of region seven customize skin care instantly for announcement, skin physiology, dermatopathology, skin
Scheme is formulated as primary efficacy raw material using fibronectin, can not only repair shallow cell, can also be repaired true
Skin and following deep layer cells, furthermore fibronectin is repaired more comprehensively than growth factor, and fibronectin can be with Regeneration and Repair epidermis, true
Skin, hair follicle, sweat gland, nerve, blood vessel etc. reach the comprehensive reparation of structure and function and barrier action.
Summary of the invention
In view of the deficiencies of the prior art, technical problem solved by the invention is how to improve the reparation barrier function of skin
Can, it is safer to use to resist environmental stimuli.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of sensitive based on private gene customization reparation
Skin lotion carries out raw material proportioning according to private genetic test, is made of following components parts by weight: 2~8 parts of emulsifier, moisturizing
5~30 parts of agent, 5~20 parts of moisturizer, 0.1~5 part of thickener, 0.5~1 part of preservative, 1~30 part of fibronectin, glycyrrhizic acid
0.05~2 part of dipotassium, 0.1~3 part of antioxidant, 0.1~2 part of pH adjusting agent, 30~85 parts of solvent.
The emulsifier includes: stereth~2, stereth~21, stearine, the tristearin of PEG~100
One of acid esters, polysorbate~60, the smooth stearate of sorb or more than one compounding.
The emollient includes: synthesis saualane, isononyl isononanoate, dimethyl silicone polymer, caprylic capric triglycerin
One of ester, carbonic acid dioctyl ester, isopropyl palmitate, ethylhexyl palmitate or more than one compounding.
The moisturizer includes: hyaluronic acid, glycerol, propylene glycol, butanediol, trehalose, hexylene glycol, sorbierite, double sweet
One of oil, glycerin polyether~26 or more than one mixing.
The thickener includes: one of carbomer, xanthan gum, hydroxyethyl cellulose or more than one mixing.
The preservative includes: one of hydroxy acetophenone, 1,2~hexylene glycol/Phenoxyethanol/decoyl hydroximic acid or one
Kind or more mixing.
The antioxidant include: one of tocopherol, ascorbic acid, Vitamin C dipalmitate or more than one
Mixing.
The pH adjusting agent include: one of citric acid, sodium citrate, arginine, triethanolamine or more than one
Compounding.
The solvent includes: rose wate, red pomegranate flower water, golden yellow anthemidis flos water, bermuda lily water, white flower spring Huang
One of chrysanthemum water, hamamelis flower water or more than one mixing.
Another technical problem that the present invention solves is to provide a kind of reparation barrier function that can be improved skin, resists outer
Boundary stimulates the preparation method to use safer skin care item.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of sensitive based on private gene customization reparation
Skin emulsion preparation method carries out raw material proportioning according to private genetic test, raw material components is made by formula, including with
Lower step:
(1) emulsifier, emollient, antioxidant investment oil cauldron are heated to 75~85 DEG C and be uniformly dissolved, obtained oily mutually mixed
Close object A；
(2) by selected moisturizer, thickener, solvent is added emulsion pot and is heated to 80 DEG C of dissolutions, through revolving speed 3000r/min
3~5min of homogeneous, high-speed stirred keep the temperature 30min, obtain aqueous mixture B；
(3) oil mixture A is pumped into emulsion pot object B mixed with water to mix, revolving speed 3000rpm homogeneous 3~5 minutes,
20 minutes are kept the temperature under 30 turns/min mixing speed；
(4) when being cooled to 45 DEG C, preservative and fibronectin, dipotassium glycyrrhizinate is added, then adjust pH value with pH adjusting agent
To 6.0~7.0, stirs evenly, be cooled to room temperature to get finished product is arrived.
Compared with prior art, the invention has the advantages that:
Fibronectin selected by the present invention can permeate skin basal layer, by emulsifier, grease, efficacy activity object
Meticulous selection be formulated, there is clearly moist skin sense, while also having effects that splendid reparation skin barrier, in formula selected by
The active constituent fibronectin taken can promote keratinocyte proliferation, and skin cell proliferation division is promoted to increase keratohyaline layer
Particle has the function of moisturizing, promotes the normal orderly function of skin microcirculqtory system, so that it is impaired to solve stratum corneum barrier
Problem, which plays, quickly repairs effect.It arranges in pairs or groups and releives the dipotassium glycyrrhizinate of effect with antiallergic again, keep repairing effect more efficient
Safety.
Specific embodiment
A specific embodiment of the invention is further described below with reference to embodiment, but is not to limit of the invention
It is fixed.
Embodiment:
One kind repairing sensitive skin lotion based on private gene customization, carries out raw material proportioning according to private genetic test, by
Following components parts by weight are made: polysorbate~60 2 part, 1 part of the smooth stearate of sorb, 5 parts of isononyl isononanoate, poly- two
3 parts of methylsiloxane, 3 parts of caprylic capric glyceryl ester, 0.3 part of tocopherol, 4 parts of glycerol, 0.1 part of hyaluronic acid, carbomer 0.3
Part, 0.5 part of hydroxy acetophenone, 0.5 part of 1,2~hexylene glycol, 10 parts of fibronectin, 0.15 part of dipotassium glycyrrhizinate, triethanolamine 0.35
Part, 69.8 parts of rose wate.
One kind repairing sensitive skin emulsion preparation method based on private gene customization, carries out raw material according to private genetic test
Proportion, raw material components are made by formula, comprising the following steps:
(1) by polysorbate~60, the smooth stearate of sorb, isononyl isononanoate, dimethyl silicone polymer, octanoic acid
Capric acid glyceryl ester, tocopherol investment oil cauldron are heated to 75~85 DEG C and are uniformly dissolved, and obtain oil mixture A；
(2) emulsion pot is added in glycerol, hyaluronic acid, carbomer, rose wate and is heated to 80 DEG C of dissolutions, through revolving speed
3000r/min 3~5min of homogeneous, high-speed stirred keep the temperature 30min, obtain aqueous mixture B；
(3) oil mixture A is pumped into emulsion pot object B mixed with water to mix, 3~5 points of revolving speed 3000r/min homogeneous
Clock keeps the temperature 20 minutes under 30 turns/min mixing speed；
(4) when being cooled to 45 DEG C, hydroxy acetophenone, 1,2~hexylene glycol and fibronectin, dipotassium glycyrrhizinate is added, then
PH value is adjusted to 6.0~7.0 with triethanolamine, is stirred evenly, is cooled to room temperature to get finished product is arrived.
To embody the reparation barrier function that the present invention improves skin, environmental stimuli is resisted to use safer effect,
Provided with control experiment, control group 1 is using without the common skin-protection product of addition fibronectin, 2 use of control group adds on the market
Add its ingredient of the product of the present invention of fibronectin identical as embodiment, selects age bracket at 20 years old to 40 years old with sensibility flesh
Skin and have the male of pruritis, female volunteer it is each 50 use, by evaluation criterion: itch number significantly reduces, red and swollen recession journey
Degree, desquamation of skin phenomenon is reduced and the water profit state showed is appraised through comparison, and is smeared after face cleaning before sleeping daily, two groups of personnel are not
Other skin care item must be reused, experimental period is 15 days, it is as follows to obtain using effect comparation and assessment tables of data:
There are 50 to think there is reparation in 50 volunteers as it can be seen that being added to the product of the present invention of fibronectin from upper table
Effect, efficient up to 100%, existing product then only has 35 volunteers to feel effectively in 50 volunteers, and effective percentage is only up to
70%, while there are also 4% uncomfortable rates.It can be seen that the product of the present invention for being added to fibronectin, which has, repairs skin cutin
Damaged effect, and barrier, security performance are more preferable.
Detailed description is made that embodiments of the present invention in conjunction with the embodiments above, but the present invention be not limited to it is described
Embodiment.To those skilled in the art, without departing from the principles and spirit of the present invention, to these realities
The mode of applying carries out various change, modification, replacement and variant are still fallen in protection scope of the present invention.
Claims (10)
1. one kind repairs sensitive skin lotion based on private gene customization, which is characterized in that carried out according to private genetic test former
Material proportion, is made: 2~8 parts of emulsifier, 5~30 parts of emollient, 5~20 parts of moisturizer, thickener of following components parts by weight
0.1~5 part, 0.5~1 part of preservative, 1~30 part of fibronectin, 0.05~2 part of dipotassium glycyrrhizinate, 0.1~3 part of antioxidant,
0.1~2 part of pH adjusting agent, 30~85 parts of solvent.
2. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the emulsifier
Include: stereth~2, stereth~21, stearine, the stearate of PEG~100, polysorbate~
60, one of smooth stearate of sorb or more than one compounding.
3. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the emollient
It include: synthesis saualane, isononyl isononanoate, dimethyl silicone polymer, caprylic capric glyceryl ester, carbonic acid dioctyl ester, palm
One of isopropyl propionate, ethylhexyl palmitate or more than one compounding.
4. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the moisturizer
Include: hyaluronic acid, glycerol, propylene glycol, butanediol, trehalose, hexylene glycol, sorbierite, diglycerol, in glycerin polyether~26
One or more kinds of mixing.
5. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the thickener
It include: one of carbomer, xanthan gum, hydroxyethyl cellulose or more than one mixing.
6. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the preservative
It include: one of hydroxy acetophenone, 1,2~hexylene glycol/Phenoxyethanol/decoyl hydroximic acid or more than one mixing.
7. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that described anti-oxidant
Agent includes: one of tocopherol, ascorbic acid, Vitamin C dipalmitate or more than one mixing.
8. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the pH is adjusted
Agent includes: one of citric acid, sodium citrate, arginine, triethanolamine or more than one compounding.
9. as described in claim 1 repair sensitive skin lotion based on private gene customization, which is characterized in that the solvent packet
It includes: rose wate, red pomegranate flower water, golden yellow anthemidis flos water, bermuda lily water, Roman chamomile flower water, hamamelis
One of Hua Shui or more than one mixing.
10. a kind of as described in any one of claim 1 to 9 based on private gene customization reparation sensitive skin lotion preparation side
Method, which is characterized in that raw material proportioning is carried out according to private genetic test, raw material components are made by formula, including following
Step:
(1) emulsifier, emollient, antioxidant investment oil cauldron are heated to 75~85 DEG C and be uniformly dissolved, obtain oil mixture
A；
(2) by selected moisturizer, thickener, solvent is added emulsion pot and is heated to 80 DEG C of dissolutions, through revolving speed 3000r/min homogeneous 3
~5min, high-speed stirred keep the temperature 30min, obtain aqueous mixture B；
(3) oil mixture A is pumped into emulsion pot object B mixed with water to mix, revolving speed 3000rpm homogeneous 3~5 minutes, 30
Turn/min mixing speed under keep the temperature 20 minutes；
(4) preservative and fibronectin, dipotassium glycyrrhizinate are added when being cooled to 45 DEG C, then with pH adjusting agent adjust pH value to
6.0~7.0, it stirs evenly, is cooled to room temperature to get finished product is arrived.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811574880.8A CN109528543A (en) | 2018-12-21 | 2018-12-21 | One kind repairing sensitive skin lotion and preparation method thereof based on private gene customization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811574880.8A CN109528543A (en) | 2018-12-21 | 2018-12-21 | One kind repairing sensitive skin lotion and preparation method thereof based on private gene customization |
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| Publication Number | Publication Date |
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| CN109528543A true CN109528543A (en) | 2019-03-29 |
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| CN201811574880.8A Withdrawn CN109528543A (en) | 2018-12-21 | 2018-12-21 | One kind repairing sensitive skin lotion and preparation method thereof based on private gene customization |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123694A (en) * | 2019-05-30 | 2019-08-16 | 广州博妍生物科技有限公司 | A kind of antiallergic maintenance toner and preparation method thereof not adding deionized water |
| CN110170072A (en) * | 2019-05-31 | 2019-08-27 | 北京添易医学研究院 | The preparation of cell fibronectin and the method for repairing dermal tissue |
| CN110623851A (en) * | 2019-10-18 | 2019-12-31 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN113318062A (en) * | 2021-06-22 | 2021-08-31 | 杭州友丽医疗科技(集团)有限公司 | Skin barrier repairing composition, skin barrier repairing liquid and preparation method thereof |
-
2018
- 2018-12-21 CN CN201811574880.8A patent/CN109528543A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123694A (en) * | 2019-05-30 | 2019-08-16 | 广州博妍生物科技有限公司 | A kind of antiallergic maintenance toner and preparation method thereof not adding deionized water |
| CN110170072A (en) * | 2019-05-31 | 2019-08-27 | 北京添易医学研究院 | The preparation of cell fibronectin and the method for repairing dermal tissue |
| CN110623851A (en) * | 2019-10-18 | 2019-12-31 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN110623851B (en) * | 2019-10-18 | 2022-04-29 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN113318062A (en) * | 2021-06-22 | 2021-08-31 | 杭州友丽医疗科技(集团)有限公司 | Skin barrier repairing composition, skin barrier repairing liquid and preparation method thereof |
| CN113318062B (en) * | 2021-06-22 | 2022-04-12 | 杭州友丽医疗科技(集团)有限公司 | Skin barrier repairing composition, skin barrier repairing liquid and preparation method thereof |
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Application publication date: 20190329 |
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