CN107898734A - Application of the American aloe extract in external use anti pruritic moisturizing personal care articles are prepared - Google Patents
Application of the American aloe extract in external use anti pruritic moisturizing personal care articles are prepared Download PDFInfo
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- CN107898734A CN107898734A CN201810007426.8A CN201810007426A CN107898734A CN 107898734 A CN107898734 A CN 107898734A CN 201810007426 A CN201810007426 A CN 201810007426A CN 107898734 A CN107898734 A CN 107898734A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The present invention relates to application of the American aloe extract in external use anti pruritic moisturizing personal care articles are prepared.American aloe extract with the second component is mixed to get composition and has reached by the present invention cooperates with antipruritic moisture-keeping efficacy.American aloe extract and its can be used in the composition of the second component in the cosmetics of personal nursing, have safely, effectively, be easy to the antipruritic and moisture-keeping efficacy that absorbs.
Description
Technical field
The invention belongs to daily nursing product technical field, and external use anti pruritic is being prepared more particularly to a kind of American aloe extract
Application in moisturizing personal care articles.
Background technology
Skin occupies the maximum surface region of body, and serves as the protective layer of internal.Lack appropriate skin nursing
It can cause various skin problems, such as dry skin, sagging, itch, coarse, color spot, wrinkle.The reason for causing these problems is very
It is more, such as environmental pollution, ultraviolet radiation, bacterium infection, skin sensitivity.
Skin under normal circumstances, due to the water sorption and barrier function of cuticula, along with sweat gland and sebaceous glands point
The covering effect for the lipid material secreted, moisture not easily run off, and cuticula can keep certain water content, increase and holding cutin
The moisture of layer, can make skin keep soft, keep elastic force.The reason for causing cuticula water shortage and causing dry skin mainly has
Two：First, dry, relative humidity is low；Second, the normal water sorption of skin and barrier function are damaged, and this
The reason for as various skin diseases such as atopic dermatitises, therefore have dry skin the problem of being very important.Guarantor in cosmetics
Humectant mainly includes following several classes：Polyalcohols moisturizer, hyaluronic acid moisturizer, lactic acid and sodium lactate, 2-pyrrolidone-5-carboxylic acid
Sodium, ceramide type moisturizer, amide-type moisturizer, glucose esters moisturizer, collagen class moisturizer, chitin derive
Thing and chitosan etc..Their existing defects in some respects, such as：Although the glycerine of polyalcohols is absorbed in air
Moisture has the function that moisturizing, but cannot form the effect of protective film and deep water supplement.The moisture retention body of hyaluronic acid solution
Forming the film of viscoelasticity now, there is very strong water-retaining property (hyaluronic acid one in the intercellular matrix of tissue is connected such as skin
Sample has water-retaining property), it is fully transparent, without remnant and greasy feeling, and has soft, smooth and lubrication sensation, but it cannot
Horny layer of epidermis is permeated (even if the hyaluronic acid degradation thing of the short chain of 5~10 disaccharide units is not easy to pass through epidermal keratinocytes
Layer).
Itch is the common complication of sensitiveness skin, and the old and the young irrespective of sex in modern society, most useization
Cosmetic, but can induce skin irritatin, inflammation, allergy and itch etc. using cosmetics.
Cause the material of pruitus very much, it is known to histamine, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, bradykinin, protease, prostaglandin, morphine
Sample peptide etc., but because of quantitative, objective appraisal difficulty, therefore be the slow field of progress.
On the one hand treatment pruitus lean on medicine, but more importantly patient it is noted that maintenance to skin, restrains and scratches,
Scratching can cause the vicious circle more grabbed and more itched, more itch and more grab, and symptom is further aggravated.
So far to the treatment of itch, antihistaminic, anti-allergic agent of Oral preparation etc. are employed as, and is used as external application
Agent, can use antihistaminic, adrenocorticotro agent, non-steroidal anti-inflammatory agent, camphor, menthol, phenol, bigcatkin willow
Acid, tar, Crotamiton, capsaicine etc. or moisturizer (urea, the distant appropriate, vaseline of happiness etc.).However, during using Oral preparation, face
Bed effect needs the side effect of certain time and Central nervous system (happiness is slept, taediumvitae), harm to digestive system etc.
Problem is likely to occur.When on the other hand, using external preparation, antipruritic effect is insufficient, particularly long-time service steroid dose, then deposits
In offices such as general reaction, bounce-back, atrophoderma, steroids purple plague purpura, atrophoderma line, the steroids acnes such as adrenal function decline
The problem of portion's side effect.
The development trend of world today's cosmetics is to advocate green, natural, safety and environmental protection, and is had effects that certain
Property.More and more consumers wish that cosmetic Manufacture business can develop more natural, effective skin care item so that skin is more
Health.Therefore, exploitation it is natural gentle and have effects that practical cosmetic composition has become cosmetics new product development must
Need.
American aloe production is a kind of plant for originating from 2500 meters of volcanoes of Mexico's height above sea level Plain semidesert area, including blue imperial
Tongue orchid (too deficient American aloe (Agave tequilana)), spinoblast American aloe (agave salmiana), green American aloe, grey
Several species such as American aloe, thorniness American aloe and rainbow American aloe.American aloe succulence is rich in polysaccharide, is often used to ferment wine brewing,
Mescal helps weight-reducing, helps digest, resist osteoporosis, prevention diabetes B, reduce senile dementia, promoting and sleep
Deng effect.
The effect that American aloe syrup is used for external preparation for skin moisturizing ingredient is described in Chinese patent CN102316848B；And
Non- patentability document (burnt refined duckweed etc., Beihua University's journal (nature), 2 (5):377-379 (2001)) in also illustrate American aloe
Effect of the water extract in terms of mouse corrosion disease.In addition, this item purpose researcher does not have found American aloe extract and group
Report of the compound as skin preparations for extenal use in terms of skin is antipruritic with moisturizing.
The content of the invention
For the blank in above-mentioned field, the present invention provide with can be used in cosmetics safely, effectively, be easy to inhale
Receive, have the American aloe extractive composition of antipruritic moisture-keeping efficacy.
A kind of composition of plant extracts, it is characterised in that：Including American aloe extract and the second component：Glycerine, 1,3-
Propane diols, 1,2- propane diols, 1,3 butylene glycol, 1,2- pentanediols, methyl propanediol, 1,2- hexylene glycols, 1,2- ethohexadiols, 1,2-
One or more in decanediol, 1,5-PD, 1,6- hexylene glycols, 1,8- ethohexadiols, 1,2- decanediols, the American aloe stem
The weight ratio of extract and the second component is 1:99 to 99:1.
Second component is selected from：In glycerine, 1,3- propane diols, 1,2- propane diols, 1,3 butylene glycol, 1,2- pentanediols
The weight ratio of one or more, the American aloe extract and the second component is 30:70 to 70:30.
Second component is 1,3-PD, and the weight ratio of the American aloe extract and the second component is 60:40.
A kind of personal care articles, contain a effective amount of composition of plant extracts.
It is preferred that：Contain the composition of plant extracts that weight percentage is 0.01%~99%.
Wherein the content of composition of plant extracts is 1% to 20%.
Wherein the content of composition of plant extracts is 10%.
American aloe extract or above-mentioned composition of plant extracts answering in external use anti pruritic moisturizing personal care articles are prepared
With.
The nursing product is individual's skin nursing product and personal cleansing product.
According to the present invention, term " American aloe extract " refers to contain by what any appropriate ways were extracted from American aloe
There is the extract of active ingredient.
In the present invention, American aloe extract can produce that significant skin is antipruritic and moisture-keeping efficacy.Meanwhile the second component energy
Cooperative effect is enough produced so as to lift the antipruritic and moisture-keeping efficacy of said composition.For example, the effect that described two compositions produce
The desired effect when being used alone more than the American aloe extract and the second component.
In the American aloe extractive composition of the present invention the second component for including be glycerine, 1,3- propane diols, 1,2- the third two
Alcohol, 1,3 butylene glycol, sorbierite, 1,2- pentanediols, methyl propanediol, 1,2- hexylene glycols, 1,2- ethohexadiols, Decane-1,2-diol,
One or more in 1,5- pentanediols, 1,6-HD, 1,8- ethohexadiols, Decane-1,2-diol.Preferably, described second group
It is selected from：One or more in glycerine, 1,3- propane diols, 1,2- propane diols, 1,3 butanediols, 1,2- pentanediols.In the present invention
In the embodiment of offer, second component most preferably from：1,3-PD.
In the American aloe extractive composition of the present invention, the ratio of American aloe extract and the second component is 1:99 to 99:
1.Preferably, the ratio of American aloe extract and the second component is 30:70 to 70:30.In embodiment provided by the invention
In, second component is 1,3-PD, best proportion 60:40.
Another embodiment of the invention is related to a kind of individual's skin care composition or personal cleaning compositions, according to
Its usage, formulation, administer the suitable selection such as age of object, gender, symptom, itch, degree of drying, its contain 0.01% to
Composition of plant extracts described in 99% claim 1 --- based on total composition meter, when combined amount is less than 0.01%,
The effect of the present invention can not be played, even more than 99% raising that also can't see effect.Preferably, American aloe extract combination
Additive amount of the thing in personal care composition or Cleasing compositions is 1% to 20%.In the present embodiment of the invention,
The optimal additive amount of American aloe extractive composition is 10%.
Individual's skin care composition or personal cleaning compositions of the present invention can be other portions of this specification
Point described those or those known to those skilled in the art of the present technique.The non-limiting example of product includes moisturiser, protects
Wet breast, suncream, toner, foundation cream, late frost, shampoo, shower cream, facial mask.In addition, the individual's skin care composition or
Personal cleaning compositions can be made into resident or flushing product.Individual's skin care composition and personal cleaning compositions
These forms can be prepared by method well known to those skilled in the art.
The individual's skin care composition or personal cleaning compositions of the present invention can include other beneficial reagents and change
Compound, such as grease, wax class, sun-screening agent, moisturizer, antioxidant, emulsifying agent, preservative, thickener etc..
The non-limiting grease that can be used with the combination of compositions of the present invention includes：It is phytosterol isostearate, new
Diheptanoate, hydrogenated coco-glyceride class, hydrogenated rosins acid methyl esters, the poly- certain herbaceous plants with big flowers alkene of hydrogenation, caprylic/capric triglyceride,
It is palm acid ethyl hexanol ester, Sucrose acetoisobutyrate, butyl stearate, propylene glycol dibenzoate, polymethyl siloxane, pungent
Base lauryl alcohol, isoparaffin, vaseline, isobutyl palmitate, plant lanolin, castor oil, rilanit special, lecithin, hydrogenation
Lecithin, evening primrose oil, Sweet Almond Oil, wheat germ oil, avocado oil, grape-kernel oil, jojoba oil, calendula oil, rapeseed oil, smoke
Clothing grass oil, chamomile oil, sage clary oil, sunflower oil, cupu oil, coconut oil, corn oil, peppermint oil, the lauric alcohol caprylate/last of the ten Heavenly stems
Acid esters, cholesterol, hydroxy stearic acid cholesteryl ester, propylene/dicaprate, rice bran oil, rosemary oil, Salvia japonica
Oil, saualane.
The non-limiting wax class that can be used with the combination of compositions of the present invention includes：Natural beeswax, synthetic bees wax, sugarcane
Wax, candelila wax, Brazil wax, ceresine, paraffin.
The non-limiting sun-screening agent that can be used with the combination of compositions of the present invention includes chemistry and physics sun-screening agent.
The non-limiting example for the chemical sun that can be used includes：Benzophenone-3, UVINUL MS 40, salicylic acid ethyl hexyl
Ester, ethylhexyl methoxy cinnamate, butyl methoxydibenzoylmethise, Octocrilene, Uvinul T 150, to diformazan
Aminobenzoic isoamyl valerate, isooctyl p-dimethylaminobenzoate, Butesin.The physical sunscreen agent that can be used
Non-limiting example include：Zinc oxide, titanium dioxide.
The not limiting example for the moisturizer that can be used with the combination of compositions of the present invention includes：Sodium Hyaluronate, sea
Algae sugar, erythrite, glycosyl trehalose/hydrogenated starch hydrolysate, biological carbohydrate gum -1, hydrolysed corn starch, acetyl chitosamine, budding
Pullulan, avenabeta glucosan, polyglutamic acid sodium, pyrrolidone carboxylic acid salt, aloe vera extract.
The not limiting example for the antioxidant that can be used with the combination of compositions of the present invention includes：3-o ethyls are anti-bad
Hematic acid, ascorbyl palmitate, superoxide dismutase, BHA, BHT, grape seed extract, green-tea extract, pyrosulfurous acid
Sodium, tocopherol, tocopherol acetate.
In some aspects of the present invention, the composition does not include emulsifying agent.However, in other aspects, the composition
Including one or more emulsifying agents.Emulsifying agent can reduce alternate interfacial tension and improve the stability of preparation, the emulsification
Agent can be non-ionic, cation, anion and zwitterionic emulsifying agent.Non-limiting example includes：Sucrose
Stearate, stearoyl lactate, cithrol class, anhydro sorbitol acid anhydrides esters, polyoxyethylene fatty ether phosphorus
Acid esters, TEA stearates and their mixture.
The not limiting example for the preservative that can be used with the combination of compositions of the present invention includes：Parahydroxyacet-ophenone,
Enumerated in phenoxetol, parabens, sorbic acid, triclosan, Chlorhexidine and cosmetics health specification its
The compound of his classification.
The not limiting example for the thickener that can be used with the combination of compositions of the present invention includes：Sodium Polyacrylate/
C13-14 isoparaffins/trideceth -6, polyacrylic acid, xanthans, carboxymethyl cellulose, hydroxyethyl cellulose, poly- second
Diol monoester and diester, alcohol ethoxylate.
Experiment shows, using the American aloe extract naturally extracted or coordinates the second component composition, has and significantly improve
The effect of pruitus and moisturizing.
Brief description of the drawings
The antipruritic effect of Fig. 1 American aloes extract and different second components,
The moistening effect of Fig. 2 American aloes extract and different second components,
The antipruritic effect of Fig. 3 different content 1,3-PDs,
The moistening effect of Fig. 4 different content 1,3-PDs,
The antipruritic effect of different content composition in the nursing of Fig. 5 individual's skins,
The moistening effect of different content composition in the nursing of Fig. 6 individual's skins,
The antipruritic effect of different content composition in Fig. 7 personal cleansing products,
The moistening effect of different content composition in Fig. 8 personal cleansing products.
Embodiment
Hereinafter, preferred embodiment and comparative example are disclosed for ease of the understanding present invention.But following implementations are to be easier to manage
Solve the present invention and provide, protection scope of the present invention is not limited to following embodiments.
The effect of composition of the present invention, can be determined by the method known to those skilled in the art.With
Under can be used for the present invention non-limiting scheme.It should be appreciated that other verification schemes can be used, including, example
Such as objective and subjective scheme.
Embodiment 1-5 and reference examples 1-6
In the present embodiment, it is thus identified that the selection of the second component in American aloe extract and composition of the present invention, it is suppressing
Activity in terms of pruitus and moisturizing is carried out by analysis below.
Antipruritic effect is tested
Cavy is divided into 2 groups immediately, every group 10, divides embodiment to combine reference examples group.The previous day is tested, gives each group cavy
Instep behind the right side, applies sample once.Experimental day, at instep shaving behind the coarse sandpaper scratch animal right side, about 1cm2Left and right, then at this
Smear sample once in place.After 10min, start 0.01% histamine phosphate of drop 0.5mL/ at wound face, hereafter every 3min
According to 0.01%, 0.02%, 0.03%, 0.04%...... progressive concentrations, be every time 0.5mL/ only, until cavy occur licks the right side
Metapedes, using the histamine phosphate total amount for finally occurring being given when cavy turns one's head and licks right metapedes as itch-threshold.
Moistening effect is tested
Skin moisture content is measured using Nova Dermal Phase Meter moisture of skin tester.The instrument passes through
Measure the change of Skin Resistance reaction moisture content of skin：The outer layer of skin has different electrical characteristics, and when dry skin, it is led
Electric power is very poor.When the increase of its water content, electric conductivity increase, as a result, Skin Resistance changes (related to electric conductivity), can be by
For evaluating the change of skin hydration.
The subject of 10 skin moderate dryings of selection, average age 32.8 years old, before experiment in 1 week elution phase, it is desirable to only
The normal bathing of energy, but both hands forearm does not apply any moisturizer after shower.Experiment is early, late after starting to survey in subject's both hands forearm
Try position and smear test specimens, applying amount is with 2mg/cm2Calculate.Using moisture of skin tester measure subject's test department at 2 weeks
Position cuticula moisture growth rate.
As Figure 1-Figure 2, by test result it can be seen that American aloe extract, which has, improves pruitus and moisturizing
Effect, and when the second component is 1,3-PD, its improvement to pruitus in terms of moisturizing with having optimum efficiency.
Embodiment 7-11
| Component | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 |
| American aloe extract (%) | 70 | 60 | 50 | 40 | 30 |
| 1,3- propane diols (%) | 30 | 40 | 50 | 60 | 70 |
In the present embodiment, it is thus identified that American aloe extract and the second component 1,3- in American aloe extractive composition of the present invention
The optimal proportion of propane diols, its improvement in terms of pruitus with moistening effect are carried out by following analysis.
Embodiment 7-11 antipruritic effects (test method is same as above)
Embodiment 7-11 moistening effects (test method is same as above)
As Figure 3-Figure 4, by test result it can be seen that American aloe extract and 1,3-PD ratio are 60:40
When, there is optimum efficiency with moisture retention in terms of its improvement to pruitus.
Embodiment 12-15 individual's skin nursing product compositions
The preparation of individual's skin nursing product composition：The component of phase A is added into beaker, and is heated in mixing
70-75℃.Then, the component of phase B is heated to 70-75 DEG C in mixing.B phases are poured slowly into A phases, homogeneous.Mixture drops
Temperature is slowly added to phase C and phase D under stirring, stirs evenly to 40 DEG C.
Embodiment 12-15 antipruritic effects test (test method is same as above)
Embodiment 12-15 moistening effects test (test method is same as above)
As shown in Fig. 5-Fig. 6, by test result it can be seen that American aloe extractive composition adding in personal care articles
When to add ratio be 10%, there is optimum efficiency with moisture retention in terms of its improvement to pruitus.
Embodiment 16-19 personal cleaning compositions
The preparation of personal cleaning compositions：Component A is heated to 85 degree or so to all dissolving, then adds B phase components,
Fully stir evenly, be cooled to 55 degree or so addition C phase components, fully stir evenly, add D phase components, stir evenly.
Embodiment 16-19 antipruritic effects test (test method is same as above)
Embodiment 16-19 moistening effects test (test method is same as above)
As shown in figure 4, American aloe extractive composition adding in personal cleaning compositions can be seen that by test result
When to add ratio be 10%, there is optimum efficiency with moisture retention in terms of its improvement to pruitus.
The American aloe extractive composition of the present invention has good improvement pruitus and moistening effect, for treating skin
It is effective in terms of skin itch and moisturizing.The other compositions being used as by mixing a variety of materials beyond active ingredient, it is of the invention
American aloe extractive composition can be readily formulated into individual's skin nursing product and personal cleansing product composition, make easy to daily
With.
Claims (9)
- A kind of 1. composition of plant extracts, it is characterised in that：Including American aloe extract and the second component, second component Selected from glycerine, 1,3- propane diols, 1,2- propane diols, 1,3 butylene glycol, 1,2- pentanediols, methyl propanediol, 1,2- hexylene glycols, 1, 2- ethohexadiols, Decane-1,2-diol, 1,5- pentanediols, 1,6-HD, 1,8- ethohexadiols, one kind in Decane-1,2-diol or several Kind, the weight ratio of the American aloe extract and the second component is 1:99 to 99:1.
- 2. composition of plant extracts according to claim 1, second component is selected from：Glycerine, 1,3- propane diols, 1, The weight of one or more in 2- propane diols, 1,3-BDO, 1,2- pentanediols, the American aloe extract and the second component Than for 30:70 to 70:30.
- 3. composition of plant extracts according to claim 1, second component is 1,3-PD, the American aloe The weight ratio of extract and the second component is 60:40.
- 4. a kind of personal care articles, contain any composition of plant extracts of a effective amount of claim 1-3.
- 5. personal care articles according to claim 4, contain the plant extracts that weight percentage is 0.01%~99% Composition.
- 6. the content of personal care articles according to claim 5, wherein composition of plant extracts is 1% to 20%.
- 7. the content of personal care articles according to claim 6, wherein composition of plant extracts is 10%.
- 8. American aloe extract or any composition of plant extracts of claim 1-3 are preparing external use anti pruritic moisturizing Application in people's nursing product.
- 9. application according to claim 8, the nursing product is individual's skin nursing product and personal cleansing product.
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| CN201810007426.8A CN107898734B (en) | 2018-01-04 | 2018-01-04 | Application of agave extract in preparing external itching-relieving and moisturizing personal care product |
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| CN201810007426.8A CN107898734B (en) | 2018-01-04 | 2018-01-04 | Application of agave extract in preparing external itching-relieving and moisturizing personal care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108703892A (en) * | 2018-07-27 | 2018-10-26 | 广州汇朗生物科技有限公司 | The new opplication of 1,5- pentanediols |
| CN110269818A (en) * | 2019-05-14 | 2019-09-24 | 广州辰美化妆品有限公司 | Composition for skin care item |
| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
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| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
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