CN110638718A - Anti-aging preparation, anti-aging composition, and preparation method and application thereof - Google Patents
Anti-aging preparation, anti-aging composition, and preparation method and application thereof Download PDFInfo
- Publication number
- CN110638718A CN110638718A CN201911021652.2A CN201911021652A CN110638718A CN 110638718 A CN110638718 A CN 110638718A CN 201911021652 A CN201911021652 A CN 201911021652A CN 110638718 A CN110638718 A CN 110638718A
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- CN
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- Prior art keywords
- aging
- extract
- mixed system
- preparation
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 124
- 239000000203 mixture Substances 0.000 title claims abstract description 89
- 238000002360 preparation method Methods 0.000 title claims abstract description 59
- 239000000284 extract Substances 0.000 claims abstract description 84
- 239000003755 preservative agent Substances 0.000 claims abstract description 29
- 239000000419 plant extract Substances 0.000 claims abstract description 28
- 229940026314 red yeast rice Drugs 0.000 claims abstract description 20
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims abstract description 18
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims abstract description 18
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims abstract description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- 239000002562 thickening agent Substances 0.000 claims description 30
- 239000003906 humectant Substances 0.000 claims description 28
- 230000002335 preservative effect Effects 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 230000003472 neutralizing effect Effects 0.000 claims description 19
- 239000002994 raw material Substances 0.000 claims description 18
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000004321 preservation Methods 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 8
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 8
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 229960003237 betaine Drugs 0.000 claims description 8
- 229960001631 carbomer Drugs 0.000 claims description 8
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- 239000000230 xanthan gum Substances 0.000 claims description 8
- 229920001285 xanthan gum Polymers 0.000 claims description 8
- 235000010493 xanthan gum Nutrition 0.000 claims description 8
- 229940082509 xanthan gum Drugs 0.000 claims description 8
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 7
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 4
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims description 4
- 235000011438 Albizia odoratissima Nutrition 0.000 claims description 4
- 235000003880 Calendula Nutrition 0.000 claims description 4
- 240000001432 Calendula officinalis Species 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000002884 skin cream Substances 0.000 claims description 3
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 2
- 240000000559 Albizia odoratissima Species 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 39
- 230000000694 effects Effects 0.000 abstract description 10
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 5
- 239000013566 allergen Substances 0.000 abstract description 5
- 230000032677 cell aging Effects 0.000 abstract description 4
- 208000026935 allergic disease Diseases 0.000 abstract description 3
- 239000000686 essence Substances 0.000 abstract description 3
- 239000002304 perfume Substances 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 3
- 210000004927 skin cell Anatomy 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 41
- 230000000052 comparative effect Effects 0.000 description 22
- 238000001816 cooling Methods 0.000 description 20
- 239000008367 deionised water Substances 0.000 description 14
- 229910021641 deionized water Inorganic materials 0.000 description 13
- 238000010438 heat treatment Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- 230000037303 wrinkles Effects 0.000 description 9
- 230000002159 abnormal effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000032683 aging Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- 241000220433 Albizia Species 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000037394 skin elasticity Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 2
- 229940035437 1,3-propanediol Drugs 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 240000007185 Albizia julibrissin Species 0.000 description 1
- 235000011468 Albizia julibrissin Nutrition 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000305491 Gastrodia elata Species 0.000 description 1
- 241001180873 Saposhnikovia divaricata Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940002386 calendula officinalis extract Drugs 0.000 description 1
- -1 caprylyl hydroxamic Chemical compound 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911021652.2A CN110638718B (en) | 2019-10-25 | 2019-10-25 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911021652.2A CN110638718B (en) | 2019-10-25 | 2019-10-25 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110638718A true CN110638718A (en) | 2020-01-03 |
CN110638718B CN110638718B (en) | 2022-06-24 |
Family
ID=69013521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911021652.2A Active CN110638718B (en) | 2019-10-25 | 2019-10-25 | Anti-aging preparation, anti-aging composition, and preparation method and application thereof |
Country Status (1)
Country | Link |
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CN (1) | CN110638718B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111329823A (en) * | 2020-03-31 | 2020-06-26 | 名臣健康用品股份有限公司 | A skin caring cream containing red rice extract and its preparation method |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105662966A (en) * | 2016-03-02 | 2016-06-15 | 广州丹奇日用化工厂有限公司 | Anti-aging plant extract composition |
CN107550753A (en) * | 2017-10-17 | 2018-01-09 | 广州润虹医药科技股份有限公司 | A kind of composition and preparation method thereof with skin repair, anti-senescence function |
CN107951769A (en) * | 2017-12-08 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | Anti-aging face cream and preparation method and application thereof |
CN108066215A (en) * | 2017-12-27 | 2018-05-25 | 国东启 | A kind of composition of whitening and anti-aging, the skin care item and preparation method for including it |
CN109528612A (en) * | 2019-01-18 | 2019-03-29 | 广州市普高管理咨询有限公司 | Crease-resistant tightening cosmetic composition, lotion and its preparation method and application |
-
2019
- 2019-10-25 CN CN201911021652.2A patent/CN110638718B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105662966A (en) * | 2016-03-02 | 2016-06-15 | 广州丹奇日用化工厂有限公司 | Anti-aging plant extract composition |
CN107550753A (en) * | 2017-10-17 | 2018-01-09 | 广州润虹医药科技股份有限公司 | A kind of composition and preparation method thereof with skin repair, anti-senescence function |
CN107951769A (en) * | 2017-12-08 | 2018-04-24 | 广州赛莱拉干细胞科技股份有限公司 | Anti-aging face cream and preparation method and application thereof |
CN108066215A (en) * | 2017-12-27 | 2018-05-25 | 国东启 | A kind of composition of whitening and anti-aging, the skin care item and preparation method for including it |
CN109528612A (en) * | 2019-01-18 | 2019-03-29 | 广州市普高管理咨询有限公司 | Crease-resistant tightening cosmetic composition, lotion and its preparation method and application |
Non-Patent Citations (5)
Title |
---|
冯居秦 等主编: "《美容中药学》", 28 February 2015, 中国中医药出版社 * |
彭成 等主编: "《中国临床药物大辞典》", 31 August 2018, 中国医药科技出版社 * |
王建新 主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
裘炳毅 等编著: "《现代化妆品科学与技术(上册)》", 31 March 2016, 中国轻工业出版社 * |
陈功锡 等编著: "《湘西药用植物资源开发与可持续利用》", 31 May 2015, 西南交通大学出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111329823A (en) * | 2020-03-31 | 2020-06-26 | 名臣健康用品股份有限公司 | A skin caring cream containing red rice extract and its preparation method |
Also Published As
Publication number | Publication date |
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CN110638718B (en) | 2022-06-24 |
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Effective date of registration: 20220601 Address after: 361000 room 1506, building 7, Bandung International Plaza, No. 607, sishuidao, Huli District, Xiamen City, Fujian Province Applicant after: Xiamen Xiaoen yanzhushi Medical Technology Co.,Ltd. Applicant after: Han Xiao Address before: 528251 105, building 1, zone a, China enterprise green headquarters center, No. 1, Zhongjin Road, East Industrial Park, Lishui Town, Nanhai District, Foshan City, Guangdong Province Applicant before: The Guangdong bio tech Ltd. Mi Shang |
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Effective date of registration: 20220831 Address after: Room 2201-2208, No. 126 Huangpu Avenue West, Tianhe District, Guangzhou City, Guangdong Province, 510000 Patentee after: Guangzhou Zhiyi Medical Beauty Clinic Co.,Ltd. Address before: 361000 room 1506, building 7, Bandung International Plaza, No. 607, sishuidao, Huli District, Xiamen City, Fujian Province Patentee before: Xiamen Xiaoen yanzhushi Medical Technology Co.,Ltd. Patentee before: Han Xiao |
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Effective date of registration: 20240222 Address after: 136100 Group 11, Xinfa Committee, Hebei Street, Gongzhuling City, Siping City, Jilin Province Patentee after: Han Xiao Country or region after: China Address before: Room 2201-2208, No. 126 Huangpu Avenue West, Tianhe District, Guangzhou City, Guangdong Province, 510000 Patentee before: Guangzhou Zhiyi Medical Beauty Clinic Co.,Ltd. Country or region before: China |