CN114209637B - Soothing composition and application thereof - Google Patents
Soothing composition and application thereof Download PDFInfo
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- CN114209637B CN114209637B CN202111609443.7A CN202111609443A CN114209637B CN 114209637 B CN114209637 B CN 114209637B CN 202111609443 A CN202111609443 A CN 202111609443A CN 114209637 B CN114209637 B CN 114209637B
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- 239000000203 mixture Substances 0.000 title claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 86
- 239000000284 extract Substances 0.000 claims abstract description 42
- 235000014676 Phragmites communis Nutrition 0.000 claims abstract description 13
- 244000137773 Viola philippica Species 0.000 claims abstract description 13
- 229940084032 paeonia lactiflora root extract Drugs 0.000 claims abstract description 11
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 239000004359 castor oil Substances 0.000 claims description 21
- 235000019438 castor oil Nutrition 0.000 claims description 21
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 18
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims description 16
- 239000003906 humectant Substances 0.000 claims description 16
- 239000004094 surface-active agent Substances 0.000 claims description 16
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 14
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 13
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 10
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- 230000002335 preservative effect Effects 0.000 claims description 9
- 239000011703 D-panthenol Substances 0.000 claims description 8
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 8
- 235000004866 D-panthenol Nutrition 0.000 claims description 8
- 229960003949 dexpanthenol Drugs 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000003750 conditioning effect Effects 0.000 claims description 7
- 239000003205 fragrance Substances 0.000 claims description 7
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 6
- 229960000458 allantoin Drugs 0.000 claims description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- FPVJYHHGNGJAPC-UHFFFAOYSA-N 2-[3-(decanoylamino)propyl-dimethylazaniumyl]acetate Chemical compound CCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O FPVJYHHGNGJAPC-UHFFFAOYSA-N 0.000 claims description 5
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 5
- 229940073742 capramidopropyl betaine Drugs 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 4
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- 229940106189 ceramide Drugs 0.000 claims description 4
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 4
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 4
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 27
- 230000007794 irritation Effects 0.000 abstract description 21
- 239000002994 raw material Substances 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 10
- 208000002193 Pain Diseases 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 206010015946 Eye irritation Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 231100000013 eye irritation Toxicity 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 239000000419 plant extract Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 21
- 238000012360 testing method Methods 0.000 description 21
- 239000000523 sample Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 12
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 9
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 9
- 206010018910 Haemolysis Diseases 0.000 description 9
- 241001570521 Lonicera periclymenum Species 0.000 description 9
- 229960003237 betaine Drugs 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 230000008588 hemolysis Effects 0.000 description 9
- 229960002446 octanoic acid Drugs 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 210000003743 erythrocyte Anatomy 0.000 description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 7
- 238000002835 absorbance Methods 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 239000006071 cream Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
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- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 244000236658 Paeonia lactiflora Species 0.000 description 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000004709 eyebrow Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 244000167230 Lonicera japonica Species 0.000 description 1
- 235000017617 Lonicera japonica Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
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- 210000004027 cell Anatomy 0.000 description 1
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- 230000008034 disappearance Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
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- 238000011076 safety test Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
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- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The invention relates to a soothing composition and application thereof, wherein the soothing composition comprises reed extract, paeonia lactiflora root extract, honeysuckle extract and viola philippica extract. The four plant extracts of reed extract, paeonia lactiflora root extract, honeysuckle extract and viola philippica extract have the effects of resisting inflammation, resisting oxidation, relieving pain and relieving pain, and the four components are creatively combined to form a relieving composition, so that the four components have unexpected synergistic effect in the aspect of reducing the irritation of raw materials of cosmetics. The cleansing water prepared from the soothing composition is mild in cleansing water and low in eye irritation, solves the problem that the commercial cleansing water is carelessly introduced into eyes to cause intense stinging or discomfort when being used, and has important application value.
Description
Technical Field
The invention belongs to the technical field of cosmetic products, relates to a soothing composition and application thereof, and in particular relates to a soothing composition capable of remarkably reducing irritation of cosmetic raw materials and application thereof.
Background
Is good for everyone. In many cases, cosmetics are required to show the best side of the cosmetic product to help us achieve the desired result. After that, the dressing is removed, and the skin of the user is protected while the user is still true. However, many of the components in cosmetics are not suitable for long-term residence on the skin, and if the makeup removal is not complete, the residual cosmetics may block skin pores, thereby causing skin problems such as acne, comedones, blackheads and the like which are confusing. Therefore, the skin cleansing step is important, and people need to carefully select cleansing products suitable for themselves. The main makeup removing products in the current market comprise makeup removing water, makeup removing emulsion, makeup removing cream and makeup removing oil. The main components of the cleansing cream and the cleansing oil are grease and an emulsifying agent, so that the cleansing effect is strongest, but the skin feel is worst; the makeup remover consists of water and oil which account for half of the makeup remover, and the skin feel is slightly better than that of the makeup remover and the makeup remover; the main components of the cleansing water are water, a surfactant, a humectant, a preservative and the like, and the cleansing water is popular with consumers because of the advantages of convenient use, relatively mild, low irritation, high price, and the like.
For example, CN106511144a discloses a makeup remover for eyes and lips and a preparation method thereof. The eye-lip cleansing water comprises the following components in percentage by weight: PEG-8 caprylic/capric glycerides: 1-15%, preferably 5-10%: yeast extract: 0.5-10%, preferably 3-7%: tripeptide-5: 0.5-5%, preferably 1-3%; dan Chun extract: 0.5-5%, preferably 0.8-2%: humectant: 1-15%: preferably 2-8%; water: 50-90%: preferably 70-85%, the eye and lip cleansing water contains PEG-8 caprylic acid/capric acid glyceride, so that mild cleansing can be realized, eye shadow, mascara, eye line, lipstick, lip line and lip oil can be rapidly cleansing, and cleansing is not needed after cleansing, so that the use is convenient: also contains yeast extract and palmitoyl tripeptide-5, and can improve eye fine wrinkles and lip wrinkles.
CN107174560a discloses a mild moisturizing and soothing cleansing water. The cleansing water comprises the following raw material components in percentage by mass: 3-15% of nonionic surfactant, 8-18% of moisturizing functional ingredient, 3-10% of relieving functional ingredient, 0.01-0.05% of citric acid, 0.02-0.1% of sodium citrate, 0.15-0.25% of poly (aminopropyl) bisexyl and the balance of water. The nonionic surfactant used in the makeup remover has the effects of quick makeup removal and mild makeup removal through compounding in different proportions. The moisturizing functional component used by the cleansing water can effectively repair skin barrier and achieve the effects of moisturizing and supplementing water. In addition, the cleansing water has mild, sedative and soothing effects.
However, in order to facilitate the use, most of the cosmetic removal packs use spray bottles, and the cosmetic removal process often involves eyes. Although the cleansing water is milder than cleansing cream, cleansing cream and cleansing oil, the raw materials such as surfactant, humectant, preservative and the like have certain irritation, and the cleansing water can cause stinging once entering eyes, thereby bringing trouble to consumers.
Therefore, how to develop a cleansing water which is mild, has low irritation to eyes and has strong cleansing capability is an urgent problem to be solved in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a soothing composition and application thereof, in particular to a soothing composition capable of remarkably reducing the irritation of cosmetic raw materials and application thereof.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a soothing composition comprising reed extract, paeonia lactiflora extract, lonicera japonica extract and viola yedoensis extract.
The four plant extracts of reed extract, paeonia lactiflora root extract, honeysuckle extract and viola philippica extract have the effects of resisting inflammation, resisting oxidation, relieving pain and relieving pain, and the four components are creatively combined to form a relieving composition, so that the four components have unexpected synergistic effect in the aspect of reducing the irritation of raw materials of cosmetics. The cleansing water prepared from the soothing composition is mild in cleansing water and low in eye irritation, solves the problem that the commercial cleansing water is carelessly introduced into eyes to cause intense stinging or discomfort when being used, and has important application value.
Preferably, the soothing composition comprises, in parts by weight, 5-30 parts of reed extract, 2-20 parts of paeonia lactiflora root extract, 3-25 parts of honeysuckle extract and 2-20 parts of viola philippica extract.
Specific values in the above 5 to 30 parts are, for example, 5 parts, 7 parts, 10 parts, 12 parts, 15 parts, 17 parts, 20 parts, 22 parts, 25 parts, 27 parts, 30 parts, etc.
Specific values in the above 2 to 20 parts may be 2 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, etc.
Specific values in the 3-25 parts may be 3 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, 22 parts, 25 parts, etc.
In a second aspect, the present invention provides the use of a soothing composition according to the first aspect for the preparation of a cosmetic product.
Preferably, the soothing composition is present in the cosmetic product in a mass percentage of 0.1-10%, for example 0.1%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% etc.
Preferably, the cosmetic product comprises any one of cleansing water, facial cleanser, toner, emulsion or cream.
In a third aspect, the invention provides a mild and mild cleansing water, the preparation raw materials of which comprise the soothing composition and the additive according to the first aspect.
Preferably, the additive comprises any one or a combination of at least two of a surfactant, a humectant, a skin conditioning agent, a preservative, a solubilizer or a fragrance, for example, a combination of a humectant and a skin conditioning agent, a combination of a surfactant and a humectant, a surfactant and a solubilizer, and the like, and any other combination is possible.
Preferably, the mild and mild cleansing water comprises, by weight, 0.1-10 parts of a soothing composition, 60-95 parts of water, 2-20 parts of a humectant, 2-20 parts of a surfactant, 0.1-5 parts of a skin conditioning agent, 0.1-1 part of a preservative, 0.1-1 part of a solubilizer and 0.1-1 part of a fragrance.
Specific values among the above 0.1 to 10 parts are, for example, 0.1 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, and the like.
Specific values among the above 60 to 95 parts are, for example, 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, 73 parts, 75 parts, 78 parts, 80 parts, 83 parts, 85 parts, 87 parts, 90 parts, 93 parts, 95 parts, and the like.
Specific values in the above 2 to 20 parts may be 2 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, etc.
Specific values among the above 0.1 to 5 parts may be 0.1 part, 0.2 part, 0.5 part, 0.7 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, etc.
Specific values of the above 0.1 to 1 part may be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc.
Preferably, the surfactant comprises PEG-6 caprylic/capric glycerides and/or caprylyl/capramidopropyl betaine, preferably a combination of PEG-6 caprylic/capric glycerides and caprylyl/capramidopropyl betaine.
According to the invention, PEG-6 caprylic acid/capric acid glyceride and octanoyl/decanoyl amino propyl betaine surfactant are compounded, and the two surfactants are matched with each other to synergistically enhance the effect, so that the excellent cleaning capability of the cleansing water is provided.
Preferably, the humectant comprises any one or a combination of at least two of erythritol, 1, 2-pentanediol, glycerol or 1, 3-butanediol, for example, a combination of erythritol and 1, 2-pentanediol, a combination of glycerol and 1, 3-butanediol, a combination of 1, 2-pentanediol and glycerol, and the like, and any other combination manner is possible.
Preferably, the skin conditioning agent comprises any one or a combination of at least two of D-panthenol, allantoin and ceramide, for example, a combination of D-panthenol and allantoin, a combination of allantoin and ceramide, a combination of D-panthenol and ceramide, etc., and any other combination is possible.
Preferably, the preservative comprises any one or a combination of at least two of p-hydroxyacetophenone, methyl p-hydroxybenzoate, octanoyl hydroxamic acid, 1, 2-hexanediol or ethylhexyl glycerin, for example, a combination of p-hydroxyacetophenone and methyl p-hydroxybenzoate, a combination of methyl p-hydroxybenzoate and octanoyl hydroxamic acid, a combination of 1, 2-hexanediol and ethylhexyl glycerin, and the like, and any other combination manner is possible.
Preferably, the solubilizing agent comprises any one or a combination of at least two of PEG-50 hydrogenated castor oil, PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil, for example, a combination of PEG-50 hydrogenated castor oil and PEG-40 hydrogenated castor oil, a combination of PEG-60 hydrogenated castor oil and PEG-40 hydrogenated castor oil, a combination of PEG-50 hydrogenated castor oil and PEG-60 hydrogenated castor oil, and the like, and any other combination is possible, and preferably, PEG-50 hydrogenated castor oil.
The PEG-50 hydrogenated castor oil has good solubilization performance, can effectively enhance the high-temperature stability of PEG-6 caprylic acid/capric acid glyceride in the formula, and effectively prevent PEG-6 caprylic acid/capric acid glyceride from being separated out.
Preferably, the fragrance comprises a perfume.
In a fourth aspect, the invention provides a method for preparing the mild and mild cleansing water according to the third aspect, wherein the method for preparing the mild and mild cleansing water comprises the steps of mixing a soothing composition with an additive and stirring.
Preferably, the preparation method of the mild and comfortable cleansing water comprises the steps of mixing water, partial humectant, surfactant and skin conditioning agent, stirring for 20-40min at 75-85 ℃, cooling to 35-45 ℃, adding the soothing composition, preservative, solubilizer, residual humectant and aromatic, mixing, and stirring for 20-40 min. The mass percentage of the partial humectant in the whole humectant is 40-70%.
Specific values of the above 75-85deg.C include 75deg.C, 78deg.C, 79 deg.C, 80 deg.C, 81 deg.C, 82 deg.C, 83 deg.C, 84 deg.C, 85 deg.C, etc.
The specific value of the above 20-40min is 20min, 22min, 25min, 27min, 30min, 32min, 35min, 37min, 40min, etc.
Specific values of 35-45deg.C include, for example, 35deg.C, 36deg.C, 37deg.C, 38deg.C, 39deg.C, 40deg.C, 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C, etc.
Specific values in the above 40 to 70% are, for example, 40%, 42%, 45%, 47%, 50%, 52%, 55%, 57%, 60%, 62%, 65%, 67%, 70%, etc.
The numerical ranges recited herein include not only the recited point values, but also any point values between the recited numerical ranges that are not recited, and are limited to, and for the sake of brevity, the invention is not intended to be exhaustive of the specific point values that the recited range includes.
Compared with the prior art, the invention has the following beneficial effects:
firstly, the reed extract, the paeonia lactiflora root extract, the honeysuckle extract and the viola philippica extract are creatively combined to form the soothing composition, and the four components are mutually matched, so that the soothing composition has remarkable synergistic effect in the aspect of reducing the irritation of the raw materials of cosmetics. Secondly, the cleansing water is prepared by adopting the soothing composition, and the PEG-6 caprylic acid/capric acid glyceride and the octanoyl/decanoyl aminopropyl betaine are compounded to be matched with each other, so that the cleansing water has excellent cleaning capability. The cleansing water provided by the invention has strong cleaning force, simultaneously remarkably reduces the irritation of raw materials of cosmetics, is mild in cleansing water and low in irritation to eyes, solves the problem that the commercial cleansing water is carelessly introduced into eyes to cause strong stinging or discomfort when being used, and has important application value.
Detailed Description
In order to further describe the technical means adopted by the present invention and the effects thereof, the following describes the technical scheme of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples, comparative examples, application examples and comparative application examples relate to the following raw material information:
example 1
The embodiment provides a soothing composition which comprises 15 parts by weight of reed extract, 10 parts by weight of paeonia lactiflora root extract, 12 parts by weight of honeysuckle extract and 10 parts by weight of viola philippica extract.
The preparation method of the soothing composition only needs simple physical mixing of the raw materials.
Example 2
The embodiment provides a soothing composition which comprises, by weight, 6 parts of reed extract, 18 parts of paeonia lactiflora root extract, 5 parts of honeysuckle extract and 18 parts of viola philippica extract.
The preparation method of the soothing composition only needs simple physical mixing of the raw materials.
Example 3
The embodiment provides a soothing composition which comprises 23 parts by weight of reed extract, 4 parts by weight of paeonia lactiflora root extract, 15 parts by weight of honeysuckle extract and 5 parts by weight of viola philippica extract.
The preparation method of the soothing composition only needs simple physical mixing of the raw materials.
Comparative example 1
This comparative example provides a soothing composition which differs from example 1 only in the absence of the reed extract of example 1, with the other components and amounts unchanged.
The preparation method is described in example 1.
Comparative example 2
This comparative example provides a soothing composition which differs from example 1 only in the absence of paeonia lactiflora extract of example 1, as well as in the other components and amounts.
The preparation method is described in example 1.
Comparative example 3
This comparative example provides a soothing composition which differs from example 1 only in the absence of the honeysuckle extract of example 1, the other components and the content being unchanged.
The preparation method is described in example 1.
Comparative example 4
This comparative example provides a soothing composition which differs from example 1 only in the absence of the viola philippica extract of example 1, as well as in the other components and amounts.
The preparation method is described in example 1.
Comparative example 5
This comparative example provides a single reed extract.
Comparative example 6
This comparative example provides a single paeonia lactiflora root extract.
Comparative example 7
This comparative example provides a single honeysuckle extract.
Comparative example 8
This comparative example provides a single extract of viola philippica.
Application example 1
The application example provides a mild and mild cleansing water, which is prepared from 5 parts of a mild composition of example 1, 77.8 parts of water, 4 parts of erythritol, 3 parts of 1, 2-pentanediol, 5 parts of PEG-6 caprylic/capric glycerides, 3 parts of octanoyl/decanoyl aminopropyl betaine, 1 part of D-panthenol, 0.5 part of p-hydroxyacetophenone, 0.5 part of PEG-50 hydrogenated castor oil and 0.2 part of essence.
The preparation method comprises the following steps:
(1) The method comprises the steps of cleaning the related appliances of the manufacturing kettle, the container and the valve by deionized water with the temperature of more than 90 ℃, then flushing the appliances by 75% disinfection alcohol, and starting heating to volatilize the alcohol and the water.
(2) Uniformly mixing and dispersing the relieving composition with deionized water at room temperature to obtain a component B for later use; uniformly mixing PEG-50 hydrogenated castor oil and essence with deionized water at room temperature, dispersing uniformly and transparent to obtain a component C for later use; mixing 1, 2-pentanediol and p-hydroxyacetophenone at 60 ℃ until the mixture is uniform and transparent, and cooling the mixture to room temperature (25 ℃) to obtain a component D for later use.
(3) Mixing erythritol, PEG-6 caprylic/capric glyceride, capryloyl/caproyl aminopropyl betaine, and D-panthenol with water, adding into a stirring pot, stirring at 80deg.C (75 rpm) for 30min, and cooling to 40deg.C to obtain component A.
(4) Sequentially adding the component B, the component C and the component D into a stirring pot, mixing with the component A (40 ℃), stirring (75 rpm) for 30min, and cooling to room temperature.
Application example 2
The application example provides a mild and mild cleansing water, which is prepared from 5 parts of a mild composition of example 2, 68.8 parts of water, 6 parts of glycerin, 6 parts of 1, 3-butanediol, 3 parts of PEG-6 caprylic/capric glycerides, 10 parts of octanoyl/capramidopropyl betaine, 0.5 part of allantoin, 0.3 part of methyl parahydroxybenzoate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of essence.
The preparation method comprises the following steps:
(1) The method comprises the steps of cleaning the related appliances of the manufacturing kettle, the container and the valve by deionized water with the temperature of more than 90 ℃, then flushing the appliances by 75% disinfection alcohol, and starting heating to volatilize the alcohol and the water.
(2) Uniformly mixing and dispersing the relieving composition with deionized water at room temperature to obtain a component B for later use; uniformly mixing PEG-40 hydrogenated castor oil and essence with deionized water at room temperature, dispersing uniformly and transparent to obtain a component C for later use; mixing 1, 3-butanediol and methyl parahydroxybenzoate at 60 ℃ until the mixture is uniform and transparent, and cooling to room temperature (25 ℃) to obtain a component D for later use.
(3) Mixing glycerol, PEG-6 caprylic/capric glyceride, octanoyl/decanoyl aminopropyl betaine, and allantoin with water, adding into a stirring pot, stirring at 85deg.C (75 rpm) for 20min, and cooling to 45deg.C to obtain component A.
(4) Sequentially adding the component B, the component C and the component D into a stirring pot, mixing with the component A (40 ℃), stirring (75 rpm) for 20min, and cooling to room temperature.
Application example 3
The application example provides a mild and mild cleansing water, which is prepared from 5 parts of a mild composition of example 3, 77.1 parts of water, 4 parts of glycerin, 4 parts of 1, 2-pentanediol, 7 parts of PEG-6 caprylic/capric glycerides, 2 parts of octanoyl/decanoyl aminopropyl betaine, 0.5 part of D-panthenol, 0.4 part of p-hydroxyacetophenone, 0.8 part of PEG-60 hydrogenated castor oil and 0.2 part of essence.
The preparation method comprises the following steps:
(1) The method comprises the steps of cleaning the related appliances of the manufacturing kettle, the container and the valve by deionized water with the temperature of more than 90 ℃, then flushing the appliances by 75% disinfection alcohol, and starting heating to volatilize the alcohol and the water.
(2) Uniformly mixing and dispersing the relieving composition with deionized water at room temperature to obtain a component B for later use; uniformly mixing PEG-60 hydrogenated castor oil and essence with deionized water at room temperature, dispersing uniformly and transparent to obtain a component C for later use; mixing 1, 2-pentanediol and p-hydroxyacetophenone at 60 ℃ until the mixture is uniform and transparent, and cooling the mixture to room temperature (25 ℃) to obtain a component D for later use.
(3) Mixing glycerol, PEG-6 caprylic/capric glyceride, octanoyl/decanoyl aminopropyl betaine, and D-panthenol with water, adding into a stirring pot, stirring at 75deg.C (75 rpm) for 40min, and cooling to 35deg.C to obtain component A.
(4) Sequentially adding the component B, the component C and the component D into a stirring pot, mixing with the component A (40 ℃), stirring (75 rpm) for 40min, and cooling to room temperature.
Application example 4
The application example provides a mild and mild cleansing water, the preparation raw materials of which are different from those of application example 1 only in that the component of octanoyl/decanoyl aminopropyl betaine is lacked, the lacked amount is complemented by PEG-6 caprylic acid/capric acid glycerides, and the other components and the content are unchanged.
The preparation method is described in application example 1.
Application example 5
The application example provides a mild and mild cleansing water, and the preparation raw materials of the cleansing water are different from those of application example 1 only in that the component PEG-6 caprylic acid/capric acid glyceride is lacked, the lacked amount is complemented by caprylic acid/capric acid aminopropyl betaine, and the other components and the content are unchanged.
The preparation method is described in application example 1.
Comparative application examples 1 to 8
Comparative application examples 1 to 8 provided eight makeup removers whose preparation raw materials were different from application example 1 only in that the soothing composition of example 1 was replaced with the soothing composition of comparative examples 1 to 8 or a single component, respectively, in equal amounts, and the other components and contents were unchanged.
The preparation method is described in application example 1.
Test example 1
Test of heat and cold resistance stability
Sample to be tested: the makeup remover provided in application examples 1 to 5.
The testing method comprises the following steps:
30g of the sample to be tested is respectively taken and placed in A1-A5 sample bottles, each group of sample bottles are simultaneously placed in the same biochemical incubator for 24 hours, and the culture temperature is set to 45 ℃.
30g of the sample to be tested is respectively taken and placed in sample bottles B1-B5, each group of sample bottles are simultaneously placed in the same biochemical incubator for 24 hours, and the culture temperature is set to be-10 ℃.
Test results: each sample to be tested has no color change and precipitation phenomenon at 45 ℃ and-10 ℃, which indicates that the cleansing water provided by the invention has good heat and cold resistance stability.
Test example 2
Safety test
50 social volunteers meeting the requirements are selected, the ages of the social volunteers are 20-45 years, the social volunteers are randomly divided into 5 groups, and the makeup remover provided in application examples 1-5 is tried out according to the groups. And respectively taking 0.020-0.025mL of the tested sample, placing the tested sample into a plaque tester cell, and performing no treatment on the control hole. The patch test with the test object is applied to the back or forearm of the subject with hypoallergenic tape, and is applied to the skin with gentle palm pressure for 48 hr. Skin reactions were observed according to the table 1 standard 30min after removal of the plaque, 24h and 48h, respectively (after disappearance of the indentations).
TABLE 1
The results show that: the application examples 1-5 of the invention are all negative reactions, which shows that the safety of the plant composition and the derivative products thereof is guaranteed, and adverse reactions such as skin irritation, sensitization (except people who are easy to allergic or people allergic to the plant composition) and the like are not generated.
Test example 3
Cleansing water irritation test
The extent of irritation of each of application examples 1 to 5, comparative application examples 1 to 8, and a commercially available makeup remover was evaluated by using a erythrocyte hemolysis test.
Test principle: erythrocyte hemolysis experiments are based on the principle that lipids and proteins on the surface of human skin are similar to the cell membranes of erythrocytes, and the irritation degree of cosmetics is evaluated by detecting the effect of cosmetics on the release of hemoglobin and the denaturation of hemoglobin of erythrocytes.
Preparation of sample suspension
Normal saline or PBS is generally selected as a solvent, and DMSO or ethanol is selected as a solvent for a sample insoluble in normal saline or PBS. It must be ensured that the diluted sample suspensions are thoroughly mixed. Sample concentration range detection experiment: the test substance is prepared into a series of gradient suspensions of 0.001%, 0.01%, 0.1%, 1%, 10%, 20%, 30%, 40% and the like by using a solvent, the suspensions are mixed with the equal volume ratio of the red blood cell suspension, the mixture is cultured for 3 hours at 37 ℃, the supernatant is centrifugally obtained, absorbance is measured at 410nm, 540nm and 575nm of an enzyme-labeled instrument, and the absorbance is compared with the absorbance of a negative control and a positive control. According to the results, a suitable concentration was selected as a range of the concentration for the sample main test in the upper and lower sections covering 50% of the hemolysis ratio.
And selecting proper test concentration according to the detection test result, and preparing sample series concentration.
Hemolysis and protein denaturation assays
In a 2mL centrifuge tube, 500. Mu.L of the test substance and 500. Mu.L of the 2% sheep red blood cell suspension (equal volume mixing) with different concentrations are added and mixed well. Each concentration was set in 3 replicates. Solvent (normal saline or PBS) was used as a negative control (i.e., no hemolysis at all), and 0.1% SDS solution was used as a positive control (i.e., complete hemolysis). After incubation for 3h in a constant temperature incubator at 37 ℃, centrifugation is carried out at 2000rpm/min for 3min, 10 μl of supernatant is extracted, the supernatant is added to an ELISA plate (90 μl of physiological saline or PBS is added to each well in advance), and absorbance (A410 nm, A540nm, A575 nm) is measured at 410nm, 540nm, 575nm of the ELISA plate.
The hemolysis rate (%) was calculated according to the following formula:
hemolysis ratio (%) = (a-C)/(B-C) ×100;
wherein A is the average absorbance of each concentration of the sample at 410nm, B is the average absorbance of the positive control at 410nm, and C is the average absorbance of the negative control at 410 nm.
The concentration of HC50 (mg/L) in the test sample that caused 50% hemolysis of the erythrocytes was determined according to the regression equation.
The protein denaturation index DI (%) was calculated as follows:
DI (%) = (subject a 575nm /A 540nm ) /(positive control A) 575nm /A 540nm )×100。
Calculating the L/D value of the sample according to the HC50 value and the DI value: l/d=hc 50/DI, the results are shown in table 2; the cosmetic irritation degree was classified according to the RBC experimental classification standard of the european replacement method verification center (ECVAM), the classification method being:
L/D >100 was evaluated as non-irritating;
the L/D is less than or equal to 100 and is evaluated as microstimulation;
1<L/D.ltoreq.10 was evaluated as mild irritation;
0.1< L/D.ltoreq.1 is evaluated as moderate irritation;
L/D was 0.1 or less and evaluated as heavy irritation.
TABLE 2
The results show that: the L/D value obtained by testing the makeup remover provided by application examples 1-5 is very high, which shows that the irritation is very small, the L/D value obtained by testing the makeup remover provided by comparative application examples 1-8 is lower than that of application example 1, and the irritation is larger, which shows that the combination of reed extract, paeonia lactiflora root extract, honeysuckle extract and viola yedoensis extract adopted by the invention has more remarkable effect than the combination of any three or any single component in the aspect of reducing the irritation of the raw materials of cosmetics, and proves the synergistic effect of the four components.
Test example 4
Cleansing water cleaning force test
140 women aged 18-35 years were selected and randomly divided into 14 groups of 10 persons each, and the makeup remover provided in examples 1-5, comparative examples 1-8 and commercially available makeup remover were tested respectively. The same aqueous eyebrow pencil, oily eyebrow pencil, aqueous eyeliner pencil, oily eyeliner pencil, eye shadow, aqueous mascara, oily mascara, concealer, blush, lipstick were applied to the back of the hand of the cleaned subjects in the same manner (each subject was tested for all 10 color cosmetic products described above), after the same cosmetic was completely dried, the same cosmetic was dipped with the same cosmetic cotton to cover the cosmetic-applied position on the back for 5 seconds, and then rubbed in the same direction, the cosmetic cotton was replaced, the rubbing step was repeated until no color cosmetic product remained on the back, the number of rubbing times was recorded, and the average results of each group are shown in table 3.
TABLE 3 Table 3
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The results show that: the cleansing water prepared in each application example has stronger cleansing capability for various water-based or oil-based makeup products, wherein the cleansing capability of the cleansing water prepared in application examples 4 and 5 is poorer than that of application example 1, which shows that the cleansing water combines PEG-6 caprylic acid/capric acid glyceride and capryloyl/capramidopropyl betaine surfactants, and the two surfactants are matched with each other to synergistically enhance the cleansing capability of the cleansing water. In addition, the cleansing power of the cleansing water of application example 1 is not inferior to that of each comparative application example, which shows that the cleansing water provided by the invention achieves the purpose of remarkably reducing the irritation of the raw materials of cosmetics while having stronger cleansing power.
The applicant states that the present invention is described by way of the above examples, application examples, to illustrate a soothing composition of the present invention and its use, but the present invention is not limited to the above examples, application examples, i.e. it is not meant that the present invention must be practiced in dependence on the above examples, application examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (9)
1. The mild and mild cleansing water is characterized by comprising, by weight, 0.1-10 parts of a soothing composition, 60-95 parts of water, 2-20 parts of a humectant, 2-20 parts of a surfactant, 0.1-5 parts of a skin conditioner, 0.1-1 part of a preservative, 0.1-1 part of a solubilizer and 0.1-1 part of a fragrance;
the soothing composition comprises, by weight, 5-25 parts of reed extract, 4-18 parts of paeonia lactiflora root extract, 4-16 parts of honeysuckle extract and 4-18 parts of viola philippica extract;
the surfactant is a combination of PEG-6 caprylic/capric glyceride and caprylyl/capramidopropyl betaine;
the solubilizer is selected from any one or a combination of at least two of PEG-50 hydrogenated castor oil, PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil.
2. The mild and mild cleansing water according to claim 1, wherein a mass percentage of said mild and mild cleansing water is 0.1 to 10%.
3. The mild and mild cleansing water according to claim 1, wherein said humectant is selected from any one or a combination of at least two of erythritol, 1, 2-pentanediol, glycerin, and 1, 3-butanediol.
4. A mild cleansing water according to claim 1, wherein said skin conditioning agent is selected from any one or a combination of at least two of D-panthenol, allantoin and ceramide.
5. The mild and mild cleansing water according to claim 1, wherein said preservative is selected from any one or a combination of at least two of p-hydroxyacetophenone, methyl p-hydroxybenzoate, octanoyl hydroxamic acid, 1, 2-hexanediol and ethylhexyl glycerol.
6. A mild cleansing water according to claim 1, wherein said solubilizing agent is PEG-50 hydrogenated castor oil.
7. The mild and mild cleansing water according to claim 1, wherein said fragrance comprises a perfume.
8. A method for preparing the mild and mild cleansing water according to any one of claims 1 to 7, wherein the method for preparing the mild and mild cleansing water comprises mixing a soothing composition with an additive and stirring the mixture to obtain the mild and mild cleansing water;
the additives include surfactants, moisturizers, skin conditioners, preservatives, solubilizers, and fragrances.
9. The method for preparing mild and mild cleansing water according to claim 8, wherein the method for preparing mild and mild cleansing water comprises mixing water, a part of humectant, a surfactant and a skin conditioning agent, stirring at 75-85 ℃ for 20-40min, cooling to 35-45 ℃, adding a soothing composition, a preservative, a solubilizer, a residual humectant and a fragrance, mixing, and stirring for 20-40 min.
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| CN202111609443.7A CN114209637B (en) | 2021-12-24 | 2021-12-24 | Soothing composition and application thereof |
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| CN202111609443.7A Active CN114209637B (en) | 2021-12-24 | 2021-12-24 | Soothing composition and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120129602A (en) * | 2011-05-20 | 2012-11-28 | 이상록 | The cosmetic composition for moisturizing comprising the mixture of extract of flower of Rhododendron mucronulatum var. lucidum Nakai , Malus pumila var. dulcissima and Magnolia sieboldii |
| CN107929097A (en) * | 2018-01-03 | 2018-04-20 | 中山市天图精细化工有限公司 | A kind of sun-proof foam aerosol |
| CN109106664A (en) * | 2018-08-13 | 2019-01-01 | 广州皓雨投资有限公司 | Have effects that moisturizing is releived the composition of maintenance, facial mask and preparation method thereof |
| CN110123708A (en) * | 2019-04-25 | 2019-08-16 | 广州澳梓美生物科技有限公司 | It is a kind of with moisturizing, moisturizing, releive, skin care item of antioxidation and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201929886A (en) * | 2017-12-20 | 2019-08-01 | 澳大利亞商Ｖｃ Ｔｍ私人有限公司 | A clear skin supplement |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120129602A (en) * | 2011-05-20 | 2012-11-28 | 이상록 | The cosmetic composition for moisturizing comprising the mixture of extract of flower of Rhododendron mucronulatum var. lucidum Nakai , Malus pumila var. dulcissima and Magnolia sieboldii |
| CN107929097A (en) * | 2018-01-03 | 2018-04-20 | 中山市天图精细化工有限公司 | A kind of sun-proof foam aerosol |
| CN109106664A (en) * | 2018-08-13 | 2019-01-01 | 广州皓雨投资有限公司 | Have effects that moisturizing is releived the composition of maintenance, facial mask and preparation method thereof |
| CN110123708A (en) * | 2019-04-25 | 2019-08-16 | 广州澳梓美生物科技有限公司 | It is a kind of with moisturizing, moisturizing, releive, skin care item of antioxidation and its preparation method and application |
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| CN114209637A (en) | 2022-03-22 |
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