CN117243849A - Relaxing face cream applicable to sensitive muscles and preparation method thereof - Google Patents
Relaxing face cream applicable to sensitive muscles and preparation method thereof Download PDFInfo
- Publication number
- CN117243849A CN117243849A CN202311395597.XA CN202311395597A CN117243849A CN 117243849 A CN117243849 A CN 117243849A CN 202311395597 A CN202311395597 A CN 202311395597A CN 117243849 A CN117243849 A CN 117243849A
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- Prior art keywords
- emulsifier
- parts
- skin
- soothing cream
- soothing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Cosmetics (AREA)
Abstract
The invention provides a soothing face cream applicable to sensitive muscles and a preparation method thereof, wherein core raw materials of the face cream for exerting the soothing effect comprise an emulsifying agent and a skin conditioning agent; the emulsifier comprises a main emulsifier and a secondary emulsifier; the main emulsifier is hydrogenated lecithin; the skin conditioning agents include ceramides and ectoin. The main emulsifier is a natural emulsifier from soybean, can promote subcutaneous absorption, has lasting moisturizing performance, can effectively reduce irritation and reduce potential irritation; the skin conditioner selects ceramide and ectoin to match, and the ceramide and ectoin cooperate to play the effects of calming, soothing and increasing skin elasticity together.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a soothing cream applicable to sensitive muscles and a preparation method thereof.
Background
The skin physical barrier consists of sebum membrane, keratin, lipid, sandwich structure, brick wall structure, dermis mucopolysaccharide, etc., and has effects of resisting external harmful substances, irritants, ultraviolet rays, keeping moisture, regulating anti-inflammatory and antiaging. However, in recent years, many consumers have caused disorder of their own immune system due to environmental pollution, working pressure, smoking and drinking, improper diet and sleep, and in addition, improper use or excessive use of a cosmetic with improper composition can lose the moisture-keeping barrier function of skin, cause redness, stinging and tightening of skin, are liable to cause burning sensation and tingling sensation on the skin surface, and then cause high sensitization of skin, and it has been reported that the skin moisture content of adult females is only 15% or less, far below 25% of the period of infants, and the skin physical barrier is as a direct consequence of skin water deficiency, thereby accelerating aging.
Therefore, in order to get rid of the trouble of sensitive skin, products for timely relieving skin and relieving stinging are developed and become unprecedented, and therefore, substances for moisturizing, relieving and repairing skin barriers are added, so that the skin with stinging is effectively relieved, sensitive skin is smeared for a long time along the way, and the skin can return to the proper barrier moisturizing function of normal skin.
CN116440018A discloses a moisture sustained-release composition containing ectoine and a preparation method thereof, which comprises the following raw materials in parts by weight: 6-12% of butanediol, 3-10% of cyclopentadimethicone, 3-10% of glycerol, 0.5-3% of dimethicone, 0.6-5% of composite emulsifier, 0.1-2% of sodium chloride, 0.3-1% of p-hydroxyacetophenone, 0.1-3% of ectoin, 0.1-1.5% of saccharide isomer, 0.5-1% of magnesium sulfate, 0.1-0.5% of 1, 2-hexanediol/glycol, 0.1-1% of beta-glucan, 0.1-3% of nicotinamide, 0.1-2% of squalane, 0.01-0.1% of sodium hyaluronate, 0.01-0.2% of xanthan gum and 0.01-0.1% of composite essential oil, and the ectoin has excellent moisturizing and water locking capabilities, is fresh and moist based on pleasant use feeling of consumers, and the applicability of the product is improved.
CN109044864a discloses a skin care product containing ceramide and a preparation method thereof, which comprises the following steps: 0.1-2 parts of ceramide, 0.1-3 parts of purslane extract, 3-8 parts of glycerol, 2-5 parts of 1, 2-pentanediol, 0.1-0.4 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 3-5 parts of caprylic acid/capric triglyceride, 2-3 parts of squalane, 1-5 parts of shea butter, 0.5-3 parts of white beeswax, 0.1-0.5 part of tocopherol, 1-3 parts of cetostearyl alcohol, 0.6-0.9 part of cocoyl glucoside, 0.5-1 part of cocoyl alcohol, 0.5-2 parts of glycerol stearate, 0.05-0.5 part of sodium hyaluronate, 0.1-0.5 part of preservative, and deionized water and 100 parts of deionized water. The method can prepare ceramide in proportion, and can maintain moisture balance of horny layer.
CN114681385a discloses a composition for relieving and repairing, a preparation method and application in sensitive muscle repairing. Comprising the following steps: escidodine, ceramide NP, lactobacillus/soymilk fermentation product filtrate. The composition provided by the invention can realize the effects of high-efficiency protection, high-efficiency repair of barrier injury and high-efficiency moisture preservation by constructing the protective and repair barrier by matching the ectoin with the ceramide, and is suitable for repairing sensitive skin. And the lactobacillus/soybean milk fermentation product filtrate is added to synergistically act with the ectoin to further play roles of relieving, repairing and moisturizing, promote the absorption of components, and enable the barrier to recover toughness and repair skin sensitivity. Because of the structure of ceramide lipid solution, when used as water-based skin care products, a surfactant is often required to be added, and the method utilizes the ectoin and fermentation product filtrate, so that a high-dispersion system can be obtained without adding the surfactant.
Therefore, developing a cream suitable for sensitive muscles with the effects of relieving redness and repairing skin barriers is an important research point in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the soothing cream applicable to sensitive muscles and the preparation method thereof, and the cream is applicable to sensitive skin and can effectively relieve Pi Fufan red and repair skin barriers.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a soothing cream for sensitive muscles, the soothing cream comprising an emulsifier and a skin conditioner as raw materials;
the emulsifier comprises a main emulsifier and a secondary emulsifier;
the main emulsifier is hydrogenated lecithin;
the skin conditioning agents include ceramides and ectoin.
The main emulsifier is a natural emulsifier from soybean, can promote subcutaneous absorption, has lasting moisturizing performance, can effectively reduce irritation and reduce potential irritation; the skin conditioner selects the match of the ceramide and the ectoine, the ceramide can repair the protective barrier function of the skin, enhance the transportation and exchange of skin lipid, the ectoine can calm and relieve the stimulated skin and the damaged skin, can play a full spectrum protection role, prevent the skin from photoaging, can also increase the skin elasticity, recover and regulate the moisture content of the skin, and the two have synergistic effects to play a role in calm and relief together.
Preferably, the co-emulsifier comprises any one or a combination of at least two of glycerol stearate/PEG-100 stearate, PEG-20 methyl glucose sesquistearate or sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) sorbitan oleate.
Preferably, the mass ratio of the main emulsifier to the auxiliary emulsifier is (0.2-1): 1, for example, 0.4:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, etc.
Preferably, the mass ratio of ceramide to ectoin is (1-5): 1, which may be, for example, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, etc.
Preferably, the raw materials of the soothing cream further comprise a humectant.
Preferably, the humectant comprises any one or a combination of at least two of glycerin, polyglycerin-6 or hydrolyzed sodium hyaluronate.
Preferably, the raw materials of the soothing cream further comprise a fat-forming agent.
Preferably, the lipid-forming agent comprises any one or a combination of at least two of palmitic acid/stearic acid, cetostearyl alcohol, C10-18 fatty acid triglycerides, myristyl alcohol myristate, squalane, mineral oil or polydimethylsiloxane.
Preferably, the raw materials of the soothing cream further comprise an antioxidant.
Preferably, the antioxidant comprises tocopheryl acetate.
Preferably, the raw materials of the soothing cream further comprise a preservative;
preferably, the preservative comprises octylglycol-ethylhexyl glycerol and/or phenoxyethanol-ethylhexyl glycerol.
Preferably, the raw materials of the soothing cream further comprise a chelating agent, a thickening agent and a pH regulator.
Preferably, the chelating agent comprises disodium EDTA.
Preferably, the thickener comprises carbomers.
Preferably, the pH adjuster comprises aminomethylpropanol.
Preferably, the soothing cream comprises the following raw materials: a main emulsifier, a co-emulsifier, a skin conditioner, a humectant, a fat reducing agent, an antioxidant, a preservative, a chelating agent, a thickener and a pH regulator;
preferably, the co-emulsifier is a combination of glycerol stearate/PEG-100 stearate, PEG-20 methyl glucsesquistearate, and sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) sorbitan oleate.
Preferably, the skin conditioning agent is a combination of ceramide and ectoin.
Preferably, the humectant is a combination of glycerin, polyglycerin-6 and hydrolyzed sodium hyaluronate.
Preferably, the lipid-forming agent is a combination of palmitic/stearic acid, cetostearyl alcohol, C10-18 fatty acid triglycerides, myristyl alcohol myristate, squalane, mineral oil and polydimethylsiloxane.
Preferably, the antioxidant is tocopheryl acetate.
Preferably, the preservative comprises a combination of octylglycol-ethylhexyl glycerol and/or phenoxyethanol-ethylhexyl glycerol.
Preferably, the chelating agent is disodium EDTA.
Preferably, the thickener is carbomer.
Preferably, the pH adjuster is aminomethylpropanol.
Preferably, the composition, in parts by weight, the raw materials of the relief cream comprise 1-2 parts (such as 1.3 parts, 1.5 parts, 1.8 parts and the like) of hydrogenated lecithin, 0.5-1.5 parts (such as 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts and the like) of glyceryl stearate/PEG-100 stearate, 0.1-1 part (such as 0.2 part, 0.5 part, 0.8 part and the like) of PEG-20 methyl glucose sesquistearate, 0.1-1 part (such as 0.2 part, 0.5 part, 0.8 part and the like) of sodium acrylate/sodium acryloyldimethyl taurate copolymer (and isohexadecane) polysorbate-80 (and sorbitan oleate 0.1-1 part (such as 0.2 part, 0.5 part, 0.8 part and the like), 2-4 parts (such as 2.5 part, 3 part, 3.5 part and the like) of ceramide 0.5 to 1.5 parts (e.g., 0.6 part, 0.8 part, 1 part, 1.2 part, 1.4 part, etc.), 4 to 6 parts (e.g., 4.5 parts, 5 parts, 5.5 parts, etc.), 0.1 to 1 part (e.g., 0.2 part, 0.5 part, 0.8 part, etc.), 0.05 to 0.2 part (e.g., 0.08 part, 0.1 part, 0.15 part, etc.), 0.1 to 1 part (e.g., 0.2 part, 0.5 part, 0.8 part, etc.), 1 to 3 parts (e.g., 1.5 part, 2 parts, 2.5 parts, etc.), 0.5 to 1.5 parts (e.g., 0.6 part, 0.8 part, 1 part, 1.2 part, 1.4 part, etc.), 0.5 to 1.5 parts (e.g., 0.6 part, 0.8 part, 1.2 part, 1.4 part, etc.), 0.5 to 1.5 parts (e.5 parts, etc.), 0.5 to 1.5 parts (e.2 parts, etc.), 1-3 parts (e.g., 1.5 parts, 2 parts, 2.5 parts, etc.), 4-6 parts (e.g., 4.5 parts, 5 parts, 5.5 parts, etc.), 0.5-1.5 parts (e.g., 0.6 parts, 0.8 parts, 1 parts, 1.2 parts, 1.4 parts, etc.), 2-4 parts (e.g., 2.5 parts, 3 parts, 3.5 parts, etc.) of polydimethylsiloxane, 0.1-0.3 parts (e.g., 0.15 parts, 02 parts, 0.25 parts, etc.), 0.1-0.3 parts (e.g., 0.15 parts, 0.2 parts, 0.25 parts, etc.), 0.5-1 part (e.g., 0.6 parts, 0.8 parts, 0.9 parts, etc.), 0.01-0.05 parts (e.g., 2.5 parts, 3 parts, 3.5 parts, etc.), 0.1-0.3 parts (e.g., 0.02 parts, 0.25 parts, 0.3 parts, 0.04 parts (e.g., 0.0.0.0.0.0.0.0.3 parts, 0.2 parts, 0.3 parts, 0.0.3 parts, etc.), 0.1-0.5 parts (e.0.5 parts, 0.5 parts, etc.), 0.5 parts (e.g., 0.5 parts, 0.0.5 parts, etc.), 0.g., phenoxyethanol/ethylhexyl glycerol, etc.), etc., methyl (e.0.0.0.0.0.0.0.0.0.0.0.0.0.0 parts, 0.0.0.4 parts, etc. parts (e.0.0.0.0.0.0 parts, etc. parts, such g., etc. parts may be methyl esters.
The preferred soothing cream contains 4-6% of squalane, can improve skin barrier, lock moisture, moisten and preserve moisture, reduce dry lines, promote skin elasticity, reduce pigmentation, make skin softer and glossy, reduce skin roughness and make skin smoother, and meanwhile, the invention adopts plant squalane, does not cause redness or anaphylactic reaction, and has more energy-saving and environment-friendly sources.
The numerical ranges recited herein include not only the recited point values, but also any point values between the recited numerical ranges that are not recited, and are limited to, and for the sake of brevity, the invention is not intended to be exhaustive of the specific point values that the recited range includes.
In a second aspect, the present invention provides a method for preparing a soothing cream for sensitive muscles according to the first aspect, comprising:
(1) Adding water, humectant, chelating agent and thickener into a water phase pot, mixing, stirring to obtain water phase;
(2) Adding the main emulsifier, part of auxiliary emulsifier, fat-forming agent and antioxidant into an oil phase pot, mixing and stirring to obtain an oil phase substance;
(3) Pumping the water phase matters and the oil phase matters into an emulsifying pot under the vacuum condition, homogenizing, adding a pH regulator and the rest of auxiliary emulsifier, and continuing homogenizing to obtain an emulsion;
(4) Adding preservative and skin conditioner into the emulsion, and uniformly mixing to obtain the soothing cream;
the sequence of the step (1) and the step (2) is not limited.
Preferably, the preparation method comprises the following steps:
(1) Adding water, humectant, chelating agent and thickener into water phase pot at 8000-12000rpm (such as 9000rpm, 10000rpm, 11000rpm, etc.), heating to 80-90deg.C (such as 83deg.C, 85deg.C, 88 deg.C, etc.), stirring for 8-12min (such as 9min, 10min, 11min, etc.), to obtain water phase;
(2) Adding main emulsifier, partial auxiliary emulsifier, fat-imparting agent and antioxidant into oil phase pot, mixing at 80-90deg.C (such as 83deg.C, 85deg.C, 88 deg.C, etc.), 55-65rpm (56 rpm, 58rpm, 60rpm, 62rpm, 64rpm, etc.), stirring for 8-12min (such as 9min, 10min, 11min, etc.), to obtain oil phase;
(3) Drawing a part of the water phase into an emulsifying pot at 55-65rpm (56 rpm, 58rpm, 60rpm, 62rpm, 64rpm, etc.), 0.05-0.03 MPa (for example, can be-0.045 MPa, -0.04MPa, -0.035MPa, etc.), drawing the oil phase and the rest of the water phase into the emulsifying pot in turn, homogenizing for 2-4min (for example, can be 1600rpm, 1800rpm, 2000rpm, 2200rpm, 2400rpm, etc.), adding pH regulator and rest of auxiliary emulsifier, continuing for 2500-3500rpm (for example, 2600rpm, 2800rpm, 3000rpm, 3200rpm, 3400rpm, etc.), homogenizing for 2-4min (for example, can be 2.5min, 3min, 3.5min, etc.), and obtaining emulsion;
(4) Adding antiseptic and skin conditioner to the emulsion at 40-50deg.C (such as 43deg.C, 45deg.C, and 48deg.C), stirring at 2500-3500rpm (such as 2600rpm, 2800rpm, 3000rpm, 3200rpm, 3400rpm, etc.) for 8-12min (such as 9min, 10min, 11min, etc.), and making into the final product.
The numerical ranges recited herein include not only the recited point values, but also any point values between the recited numerical ranges that are not recited, and are limited to, and for the sake of brevity, the invention is not intended to be exhaustive of the specific point values that the recited range includes.
Compared with the prior art, the invention has the following beneficial effects:
the main emulsifier is a natural emulsifier from soybean, can promote subcutaneous absorption, has lasting moisturizing performance, can effectively reduce irritation and reduce potential irritation;
the skin conditioner selects the match of the ceramide and the ectoin, the ceramide can repair the protective barrier function of the skin, enhance the transportation and exchange of skin lipid, the ectoin can calm and relieve the stimulated skin and the damaged skin, can play a full spectrum protection role, prevent the skin from photoaging, can also increase the skin elasticity, recover and regulate the moisture content of the skin, and the two cooperate to play roles of calm and relieve and increase the skin elasticity together;
further, by selecting oils such as squalane and silicone oil, the squalane is easy to absorb, improves skin protection barrier, does not cause redness or anaphylactic reaction, can play a role in efficient restoration, has good sealing property, can effectively help skin lock water, and has excellent water locking effect when being used together.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.
The terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.
"optional" or "any" means that the subsequently described event or event may or may not occur, and that the description includes both cases where the event occurs and cases where the event does not.
The indefinite articles "a" and "an" preceding an element or component of the invention are not limited to the requirement (i.e. the number of occurrences) of the element or component. Thus, the use of "a" or "an" should be interpreted as including one or at least one, and the singular reference of an element or component includes the plural reference unless the amount clearly dictates otherwise.
The description of the terms "one embodiment," "some embodiments," "exemplarily," "specific examples," or "some examples," etc., herein described means that a specific feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this document, the schematic representations of the above terms are not necessarily for the same embodiment or example.
The reagents or instrument sources in the following examples are as follows:
squalane: NIPPON SURFACTANT INDUSTRIES co, ltd;
glycerol stearate/PEG-100 stearate: croda Singapore Pte Ltd;
sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) water (and) sorbitan oleate: SEPPIC s.a.;
palmitic acid/stearic acid: indonesia grease chemical group;
octanediol/ethylhexyl glycerol: ashland LLC;
phenoxyethanol/ethylhexyl glycerol: ashland LLC.
Example 1
The embodiment provides a soothing cream, which comprises the following raw materials:
phase A: 5 parts of glycerol, 0.3 part of carbomer, 0.5 part of polyglycerol-6, 0.02 part of EDTA disodium, 0.1 part of hydrolyzed sodium hyaluronate and 65.93 parts of deionized water;
and B phase: hydrogenated lecithin 1.5 parts, (glycerol stearate/PEG-100 stearate) 1 part, PEG-20 methyl glucose sesquistearate 0.5 parts, (palmitic acid/stearic acid) 0.5 parts, cetostearyl alcohol 2 parts, C10-18 fatty acid triglycerides 1 part, myristyl alcohol myristate 2 parts, squalane 5 parts, mineral oil 1 part, polydimethylsiloxane 3 parts, tocopherol acetate 0.2 parts;
and C phase: 0.15 parts of aminomethylpropanol, 0.5 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) water (and) sorbitan oleate;
and D phase: 3 parts of ceramide, (phenoxyethanol/ethylhexyl glycerol) 0.6 parts and (octylglycol/ethylhexyl glycerol) 0.2 parts;
e phase: 1 part of ectoine and 5 parts of deionized water;
the preparation method comprises the following steps:
(1) Adding deionized water into a water phase pot, starting stirring to 1000rpm, sequentially adding other raw materials in the phase A, stirring and heating to 85 ℃, and preserving heat for 10min to obtain a water phase substance;
(2) Sequentially adding the phase B raw materials into an oil phase pot, starting stirring at 60rpm, heating to 85 ℃, and preserving heat for 10min to obtain an oil phase substance;
(3) Starting an emulsifying pot, stirring at 60rpm, vacuumizing to-0.04 MPa, pumping 3/4 of the water phase into the emulsifying pot, pumping the oil phase raw material, pumping the rest 1/4 of the water phase into the emulsifying pot, and starting external homogenization for 3min at 2000rpm;
(4) After homogenization is completed, adding the phase C into an emulsifying pot, stirring, vacuum stirring, starting external circulation for homogenization for 3min at a speed of 3000rpm to obtain an emulsion;
(5) Keeping stirring speed and vacuum unchanged, starting cooling water to cool to 45 ℃, sequentially adding D phase and E phase raw materials (wherein the E phase raw materials are dissolved before adding) into the emulsion, stirring for 10min, and cooling to room temperature to obtain the soothing cream.
Example 2
The embodiment provides a soothing cream, which comprises the following raw materials:
phase A: 4 parts of glycerol, 0.4 part of carbomer, 0.2 part of polyglycerol-6, 0.05 part of EDTA disodium, 0.2 part of hydrolyzed sodium hyaluronate and 77.15 parts of deionized water;
and B phase: 1 part of hydrogenated lecithin, (glycerol stearate/PEG-100 stearate) 1.5 parts, PEG-20 methyl glucose sesquistearate 0.2 parts, 1 part of (palmitic acid/stearic acid), 1 part of cetostearyl alcohol, 1.5 parts of C10-18 fatty acid triglycerides, 1 part of myristyl alcohol myristate, 6 parts of squalane, 0.5 part of mineral oil, 2 parts of polydimethylsiloxane and 0.3 part of tocopheryl acetate;
and C phase: 0.2 parts of aminomethylpropanol, 1 part of sodium acrylate/sodium acryloyldimethyl taurate copolymer (and isohexadecane (and) polysorbate-80 (and) water (and) sorbitan oleate;
and D phase: 2 parts of ceramide, (phenoxyethanol/ethylhexyl glycerol) 0.6 part and (octylglycol/ethylhexyl glycerol) 0.2 part;
e phase: 1.5 parts of ectoine and 6 parts of deionized water;
the preparation method comprises the following steps:
(1) Adding deionized water into a water phase pot, starting stirring to 12000rpm, sequentially adding other raw materials in the phase A, stirring, heating to 90 ℃, and preserving heat for 8min to obtain a water phase substance;
(2) Sequentially adding the phase B raw materials into an oil phase pot, starting stirring at 65rpm, heating to 80 ℃, and preserving heat for 12min to obtain an oil phase substance;
(3) Starting the emulsifying pot to stir at 65rpm, vacuumizing to-0.03 MPa, pumping 1/2 of the water phase into the emulsifying pot, pumping the oil phase raw material into the emulsifying pot, pumping the rest 1/2 of the water phase into the emulsifying pot, and starting external homogenization for 2min at 2500rpm;
(4) After homogenization is completed, adding the phase C into an emulsifying pot, stirring under vacuum and constant stirring, starting external circulation for homogenization for 2min at 3500rpm to obtain an emulsion;
(5) Keeping stirring speed and vacuum unchanged, starting cooling water to cool to 50deg.C, sequentially adding D phase and E phase materials (wherein E phase materials are dissolved before adding) into the emulsion, stirring for 8min, and cooling to room temperature to obtain the relieving cream.
Example 3
The embodiment provides a soothing cream, which comprises the following raw materials:
phase A: 6 parts of glycerin, 0.2 part of carbomer, 6 1 parts of polyglycerol-6 1 parts of EDTA disodium, 0.01 part of hydrolyzed sodium hyaluronate and 67.34 parts of deionized water;
and B phase: 2 parts of hydrogenated lecithin, (glycerol stearate/PEG-100 stearate) 0.8 part, PEG-20 methyl glucose sesquistearate 1 part, (palmitic acid/stearic acid) 0.1 part, cetostearyl alcohol 3 parts, C10-18 fatty acid triglycerides 0.5 part, myristyl alcohol myristate 3 parts, squalane 4 parts, mineral oil 1.5 parts, polydimethylsiloxane 4 parts, tocopheryl acetate 0.1 parts;
and C phase: 0.2 parts of aminomethylpropanol, 0.4 parts of sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) water (and) sorbitan oleate;
and D phase: 4 parts of ceramide, (phenoxyethanol/ethylhexyl glycerol) 0.6 part and (octylglycol/ethylhexyl glycerol) 0.2 part;
e phase: 0.8 parts of ectoine and 3 parts of deionized water;
the preparation method comprises the following steps:
(1) Adding deionized water into a water phase pot, starting stirring to 12000rpm, sequentially adding other raw materials in the phase A, stirring, heating to 90 ℃, and preserving heat for 8min to obtain a water phase substance;
(2) Sequentially adding the phase B raw materials into an oil phase pot, starting stirring at 65rpm, heating to 80 ℃, and preserving heat for 12min to obtain an oil phase substance;
(3) Starting the emulsifying pot to stir at 65rpm, vacuumizing to-0.03 MPa, pumping 1/2 of the water phase into the emulsifying pot, pumping the oil phase raw material into the emulsifying pot, pumping the rest 1/2 of the water phase into the emulsifying pot, and starting external homogenization for 2min at 2500rpm;
(4) After homogenization is completed, adding the phase C into an emulsifying pot, stirring under vacuum and constant stirring, starting external circulation for homogenization for 2min at 3500rpm to obtain an emulsion;
(5) Keeping stirring speed and vacuum unchanged, starting cooling water to cool to 50deg.C, sequentially adding D phase and E phase materials (wherein E phase materials are dissolved before adding) into the emulsion, stirring for 8min, and cooling to room temperature to obtain the relieving cream.
Example 4
This example provides a soothing cream which differs from example 1 only in that the ceramide is adjusted to 1.5 parts and the exendin is adjusted to 2.5 parts, the preparation method being as described in example 1.
Example 5
This example provides a soothing cream which differs from example 1 only in that the ceramide is adjusted to 3.5 parts and the exendin is adjusted to 0.5 parts, the preparation method being as described in example 1.
Comparative example 1
This comparative example provides a soothing cream which differs from example 1 only in that no ceramide is added, and that exendin is adjusted for 4 parts, the preparation method being referred to example 1.
Comparative example 2
This comparative example provides a soothing cream which differs from example 1 only in that no ectoin was added and the ceramide was adjusted to 4 parts, the preparation method being referred to example 1.
Comparative example 3
This comparative example provides a soothing cream which differs from example 1 only in that no hydrogenated lecithin was added, and the glyceryl stearate/PEG-100 stearate was adjusted to 2.5 parts, as prepared in accordance with example 1.
Test example 1
Irritation test
Experiments performed using the endpoint evaluation method should calculate an Endpoint Score (ES), the sum of the extent of bleeding, coagulation and vascular lysis observed for each chick embryo; ES is the sum of the number of chick embryo scores. In the result, ES is less than or equal to 12, and the stimulation is not/slightly generated; if 12< ES <16, then moderate irritation; if S is more than or equal to 16, the product is strong in irritation/corrosiveness. The test results are shown in Table 1.
TABLE 1
Sample of | ES scoring | Irritation classification |
Example 1 | 6 | No/light irritation |
Example 2 | 7 | No/light irritation |
Example 3 | 7 | No/light irritation |
Example 4 | 7 | No/light irritation |
Example 5 | 6 | No/light irritation |
Comparative example 1 | 6 | No/light irritation |
Comparative example 2 | 7 | No/light irritation |
Comparative example 3 | 7 | No/light irritation |
From the table data, the soothing creams prepared by the examples and the comparative examples provided by the invention meet the requirements of no or light irritation.
Test example 2
Skin stratum corneum moisture content test
Test instrument: a skin stratum corneum moisture content meter Comeometer;
testing: 10 days (D10), 28 days (D28);
test object: 30 healthy women aged 20-45 years;
measurement area: cheek (left/right);
interpretation of test parameters:
skin stratum corneum moisture content: the higher the value, the more moisture the skin's stratum corneum is. Units: comeometer Unit, abbreviated C.U.. Moisture change rate (%) = (Dn-D0) ×100%/D0, where Dn may be the moisture content of the subject's skin at D10 or D28 and D0 is the initial moisture content of the subject's skin. The test results are shown in Table 2.
TABLE 2
Sample of | Moisture change rate over 10 days (%) | 28 day moisture Change Rate (%) |
Example 1 | 19.7 | 24.88 |
Example 2 | 15.6 | 21.1 |
Example 3 | 17.5 | 23.6 |
Example 4 | 15.1 | 19.3 |
Example 5 | 14.8 | 19.6 |
Comparative example 1 | 14.6 | 18.6 |
Comparative example 2 | 14.5 | 14.8 |
Comparative example 3 | 16.7 | 20.5 |
From the table data, the soothing creams provided in examples 1-3 have good moisturizing effect, and slightly reduced moisturizing effect when the ratio of ceramide to ectoin is outside (1-5): 1; when only one of ceramide and ectoin is used as a skin conditioner, the moisturizing effect is further reduced; when the main emulsifier hydrogenated lecithin was replaced with a conventional emulsifier, the 28-day moisture condition showed a less effective moisturizing effect than examples 1 to 3.
Test example 3
Skin percutaneous moisture loss test
Test instrument: skin moisture loss tester Aquaflux;
testing: 10 days (D10), 28 days (D28);
test object: 30 healthy women aged 20-45 years;
measurement area: cheek (left/right);
interpretation of test parameters:
percutaneous water diversionLoss of volume: the lower the value, the less percutaneous moisture loss. Units: g/(h.m) 2 ). Percutaneous water loss (%) = (Dn-D0) ×100%/D0, where Dn may be the percutaneous water loss amount of the skin of the subject at D10 or D28, and D0 is the initial percutaneous water loss amount of the skin of the subject. The test results are shown in Table 3.
TABLE 3 Table 3
Sample of | Rate of change of water loss through skin 10 days (%) | Rate of change of loss of water through skin for 28 days (%) |
Example 1 | -10.08 | -14.96 |
Example 2 | -9.01 | -13.97 |
Example 3 | -8.78 | -12.88 |
Example 4 | -7.01 | -10.56 |
Example 5 | -7.5 | -11.22 |
Comparative example 1 | -4.12 | -5.67 |
Comparative example 2 | -6.74 | -8.75 |
Comparative example 3 | -9.56 | -13.24 |
According to the table data, the skin percutaneous water loss rate of the soothing cream provided by the invention in the examples 1-3 is obviously reduced, and when the ratio of ceramide to ectoin is outside the (1-5): 1, the skin water loss rate is slightly increased; when only one of ceramide and ectoin is used as a skin conditioner, the water loss rate of the skin is slightly increased and further increased, and the water locking effect is reduced; when the main emulsifier hydrogenated lecithin was replaced with a conventional emulsifier, the skin water loss rate was increased as compared with examples 1-2.
Test example 4
Skin color redness test
Test instrument: skin color tester Skin-color;
testing: 10 days (D10), 28 days (D28);
test object: 30 healthy women aged 20-45 years;
measurement area: cheek (left/right);
interpretation of test parameters:
skin color: the lower the a value, the lighter the skin redness. a value change rate (%) = (Dn-D0) ×100%/D0, where Dn may be a value of a of the skin of the subject at D10 or D28, and D0 is an initial a value of the skin of the subject. The test results are shown in Table 4.
TABLE 4 Table 4
From the table data, the soothing efficacy is slightly reduced when the ratio of ceramide to ectoin is outside (1-5): 1; when only one of ceramide and ectoin is used as a skin conditioner, the soothing and redness efficacy on skin is further reduced; when the main emulsifier hydrogenated lecithin was replaced with a conventional emulsifier, the soothing efficacy was reduced as compared with examples 1 and 3.
The applicant states that the process of the invention is illustrated by the above examples, but the invention is not limited to, i.e. it does not mean that the invention has to be carried out in dependence on the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (10)
1. A soothing cream suitable for sensitive muscles, characterized in that the raw materials of the soothing cream comprise an emulsifier and a skin conditioner;
the emulsifier comprises a main emulsifier and a secondary emulsifier;
the main emulsifier is hydrogenated lecithin;
the skin conditioning agents include ceramides and ectoin.
2. The soothing cream of claim 1 wherein the co-emulsifier comprises any one or a combination of at least two of glycerol stearate/PEG-100 stearate, PEG-20 methyl glucose sesquistearate or sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) sorbitan oleate.
3. A soothing cream according to claim 1 or 2, characterized in that the mass ratio of main emulsifier to co-emulsifier is (0.2-1): 1;
preferably, the mass ratio of the ceramide to the ectoin is (1-5): 1.
4. A soothing cream according to any of claims 1 to 3 wherein the raw materials of the soothing cream further comprise a humectant;
preferably, the humectant comprises any one or a combination of at least two of glycerin, polyglycerin-6 or hydrolyzed sodium hyaluronate.
5. The soothing cream of any of claims 1 to 4 wherein the raw materials of the soothing cream further comprise a fat-imparting agent;
preferably, the lipid-forming agent comprises any one or a combination of at least two of palmitic acid/stearic acid, cetostearyl alcohol, C10-18 fatty acid triglycerides, myristyl alcohol myristate, squalane, mineral oil or polydimethylsiloxane.
6. A soothing cream according to any of claims 1 to 5, wherein the raw materials of the soothing cream further comprise an antioxidant;
preferably, the antioxidant comprises tocopheryl acetate;
preferably, the raw materials of the soothing cream further comprise a preservative;
preferably, the preservative comprises octylglycol-ethylhexyl glycerol and/or phenoxyethanol-ethylhexyl glycerol.
7. The soothing cream of any of claims 1 to 6 wherein the raw materials of the soothing cream further comprise a chelating agent, a thickener and a pH adjuster;
preferably, the chelating agent comprises disodium EDTA;
preferably, the thickener comprises carbomers;
preferably, the pH adjuster comprises aminomethylpropanol.
8. A soothing cream according to any of claims 1 to 7, characterized in that the raw materials of the soothing cream comprise: a main emulsifier, a co-emulsifier, a skin conditioner, a humectant, a fat reducing agent, an antioxidant, a preservative, a chelating agent, a thickener and a pH regulator;
preferably, the co-emulsifier is a combination of glycerol stearate/PEG-100 stearate, PEG-20 methyl glucose sesquistearate and sodium acrylate/sodium acryloyldimethyl taurate copolymer (and) isohexadecane (and) polysorbate-80 (and) sorbitan oleate;
preferably, the skin conditioning agent is a combination of ceramide and ectoin;
preferably, the humectant is a combination of glycerin, polyglycerin-6 and hydrolyzed sodium hyaluronate;
preferably, the lipid-forming agent is a combination of palmitic/stearic acid, cetostearyl alcohol, C10-18 fatty acid triglycerides, myristyl alcohol myristate, squalane, mineral oil and polydimethylsiloxane;
preferably, the antioxidant is tocopheryl acetate;
preferably, the preservative comprises a combination of octylglycol-ethylhexyl glycerol and/or phenoxyethanol-ethylhexyl glycerol;
preferably, the chelating agent is disodium EDTA;
preferably, the thickener is carbomer;
preferably, the pH adjuster is aminomethylpropanol.
9. A method of preparing a soothing cream for sensitive muscles as claimed in any of claims 1 to 8, wherein the method comprises:
(1) Adding water, humectant, chelating agent and thickener into a water phase pot, mixing, stirring to obtain water phase;
(2) Adding the main emulsifier, part of auxiliary emulsifier, fat-forming agent and antioxidant into an oil phase pot, mixing and stirring to obtain an oil phase substance;
(3) Pumping the water phase matters and the oil phase matters into an emulsifying pot under the vacuum condition, homogenizing, adding a pH regulator and the rest of auxiliary emulsifier, and continuing homogenizing to obtain an emulsion;
(4) Adding preservative and skin conditioner into the emulsion, and uniformly mixing to obtain the soothing cream;
the sequence of the step (1) and the step (2) is not limited.
10. The preparation method according to claim 9, characterized in that the preparation method comprises:
(1) Adding water, humectant, chelating agent and thickener into water phase pot at 8000-12000rpm, heating to 80-90deg.C, stirring for 8-12min to obtain water phase;
(2) Adding main emulsifier, partial auxiliary emulsifier, fat-imparting agent and antioxidant into oil phase pot, mixing and stirring at 80-90deg.C and 55-65rpm for 8-12min to obtain oil phase;
(3) Pumping a part of the water phase matters into an emulsifying pot at 55-65rpm and minus 0.05-minus 0.03MPa, pumping the oil phase matters and the rest water phase matters into the emulsifying pot in sequence, homogenizing for 2-4min at 1500-2500rpm, adding a pH regulator and the rest auxiliary emulsifier, and continuing homogenizing for 2-4min at 2500-3500rpm to obtain an emulsion;
(4) Adding antiseptic and skin conditioner into the emulsion at 40-50deg.C, stirring at 2500-3500rpm for 8-12min to obtain the relieving cream.
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