CN114983840A - Skin barrier repairing composition capable of resisting external stimulation - Google Patents
Skin barrier repairing composition capable of resisting external stimulation Download PDFInfo
- Publication number
- CN114983840A CN114983840A CN202210586188.7A CN202210586188A CN114983840A CN 114983840 A CN114983840 A CN 114983840A CN 202210586188 A CN202210586188 A CN 202210586188A CN 114983840 A CN114983840 A CN 114983840A
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- CN
- China
- Prior art keywords
- extract
- skin barrier
- parts
- oil
- glyceryl ether
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- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 30
- 230000000638 stimulation Effects 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 23
- 239000000419 plant extract Substances 0.000 claims abstract description 22
- 150000003377 silicon compounds Chemical class 0.000 claims abstract description 15
- 239000000284 extract Substances 0.000 claims description 64
- 150000002148 esters Chemical class 0.000 claims description 39
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 39
- 230000008439 repair process Effects 0.000 claims description 17
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 17
- 239000008158 vegetable oil Substances 0.000 claims description 17
- 239000003921 oil Substances 0.000 claims description 16
- 235000019198 oils Nutrition 0.000 claims description 16
- 241000157280 Aesculus hippocastanum Species 0.000 claims description 15
- 235000010181 horse chestnut Nutrition 0.000 claims description 15
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 14
- -1 polydimethylsiloxane Polymers 0.000 claims description 14
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 13
- 235000021302 avocado oil Nutrition 0.000 claims description 13
- 239000008163 avocado oil Substances 0.000 claims description 13
- 239000010480 babassu oil Substances 0.000 claims description 13
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 13
- 229930182478 glucoside Natural products 0.000 claims description 13
- 150000008131 glucosides Chemical class 0.000 claims description 13
- 235000008390 olive oil Nutrition 0.000 claims description 13
- 239000004006 olive oil Substances 0.000 claims description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 13
- 229940059958 centella asiatica extract Drugs 0.000 claims description 11
- 229940038580 oat bran Drugs 0.000 claims description 11
- 241001071795 Gentiana Species 0.000 claims description 10
- 235000020971 citrus fruits Nutrition 0.000 claims description 10
- 150000003961 organosilicon compounds Chemical class 0.000 claims description 10
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 8
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 8
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 claims description 7
- JSOVGYMVTPPEND-UHFFFAOYSA-N 16-methylheptadecyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)(C)C JSOVGYMVTPPEND-UHFFFAOYSA-N 0.000 claims description 7
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 7
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 claims description 7
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 7
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 claims description 7
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 7
- LPGFSDGXTDNTCB-UHFFFAOYSA-N [3-(16-methylheptadecanoyloxy)-2,2-bis(16-methylheptadecanoyloxymethyl)propyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC(C)C)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C LPGFSDGXTDNTCB-UHFFFAOYSA-N 0.000 claims description 7
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 7
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 7
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 claims description 7
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 7
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 7
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 7
- 229940060384 isostearyl isostearate Drugs 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 235000019871 vegetable fat Nutrition 0.000 claims description 5
- 239000002085 irritant Substances 0.000 claims description 4
- 231100000021 irritant Toxicity 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 4
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 4
- 229920002545 silicone oil Polymers 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 241000205585 Aquilegia canadensis Species 0.000 claims description 2
- 241001474374 Blennius Species 0.000 claims description 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 229940064064 purslane extract Drugs 0.000 claims description 2
- 230000003716 rejuvenation Effects 0.000 claims 4
- 244000164480 Curcuma aromatica Species 0.000 claims 1
- 235000003398 Curcuma aromatica Nutrition 0.000 claims 1
- 241000202807 Glycyrrhiza Species 0.000 claims 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 239000004519 grease Substances 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 239000011241 protective layer Substances 0.000 abstract description 3
- 230000037307 sensitive skin Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 229940049964 oleate Drugs 0.000 description 8
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 8
- 230000007794 irritation Effects 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241001672694 Citrus reticulata Species 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 5
- 229910052609 olivine Inorganic materials 0.000 description 5
- 239000010450 olivine Substances 0.000 description 5
- 230000000172 allergic effect Effects 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 240000007817 Olea europaea Species 0.000 description 3
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 244000075850 Avena orientalis Species 0.000 description 2
- 235000007319 Avena orientalis Nutrition 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229940087603 grape seed extract Drugs 0.000 description 2
- 235000002532 grape seed extract Nutrition 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000001717 vitis vinifera seed extract Substances 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001135871 Gentiana scabra Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002454 curcuma longa l. root extract Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/892—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a hydroxy group, e.g. dimethiconol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a skin barrier repairing composition capable of resisting external stimulation. According to the invention, the organic silicon compound and the isomeric grease compound are compounded to form a breathable protective layer, so that the external stimulation can be resisted, the plant extract can be assisted to continuously act on sensitive skin, and a better skin repairing effect is achieved under the synergistic effect of the plant grease derivative.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a skin barrier repairing composition capable of resisting external stimulation.
Background
With the development of modern social life, the pace of life of people is faster and faster, the physical barrier of skin is damaged by long-time radiation of electronic products such as computer screens, mobile phones and the like, the invasion of external harmful substances cannot be resisted, the skin is dry, aged, reddened and pigment precipitated easily due to external stimulation, and skin diseases such as dermatitis, allergy, acne and the like can be even caused due to poor skin resistance.
In the prior art, a patent application document with an authorization publication number of CN108721154B discloses a skin care product for skin moisturizing and barrier repair and a preparation method thereof, and the skin care product prepared by adding raw materials such as marine fish skin collagen oligopeptide, kelp extract, low molecular weight sodium hyaluronate and the like has a good moisturizing and repairing effect and can improve erythema. However, the use of marine fish skin collagen oligopeptide in excess can cause allergic diseases.
Patent document No. CN103705426B discloses an antiallergic moisturizing composition for repairing skin barrier function and an external preparation thereof, wherein the skin surface layer and deep layer barrier function is repaired by adding components such as grape seed extract and niacinamide, but niacinamide may irritate the skin, and grape seed extract as a plant extract may cause poor weather resistance and short shelf life of the composition.
Therefore, there is a need for a skin barrier repair composition that can resist external irritation, has a good moisturizing and repairing effect, does not irritate the skin, has excellent high and low temperature stability, and is not prone to deterioration.
Disclosure of Invention
In order to solve the above problems, according to a first aspect of the present invention, there is provided a skin barrier repair composition for external irritation resistance, which is prepared from the following raw materials in parts by weight: 1-40 parts of organic silicon compound, 5-50 parts of isoalkane and oil compounds thereof, 0.5-15 parts of vegetable oil derivatives and 0.02-5 parts of plant extracts.
Preferably, the skin barrier repairing composition capable of resisting external stimulation is prepared from the following raw materials in parts by weight: 10-35 parts of organic silicon compound, 15-40 parts of isoalkane and oil compounds thereof, 2-13 parts of vegetable oil derivatives and 1-4 parts of plant extract.
Preferably, the organosilicon compound is one or more of polydimethylsiloxane, dimethiconol, octyl polymethylsiloxane, cyclopentadimethylsiloxane, methyl-terminated silicone oil and polyether modified silicone oil; further preferred are polydimethylsiloxane and dimethiconol.
Preferably, the weight ratio of the polydimethylsiloxane to the dimethiconol is (0.2-20): (0.1-10); further preferably (5-15): (2-8); further, 2: 1.
The applicant finds that the dimethiconol is selected as the organic silicon compound, so that the repairing capacity of the skin can be improved, the use feeling is comfortable and not greasy, probably because the texture is thick and heavy, the water of the skin can be firmly locked, the water loss is prevented, the external stimulation is resisted, but the skin is not breathable, pores can be blocked, the risk of acne is caused, the horny layer is increased, and skin diseases such as eczema and the like are easily caused. The applicant has surprisingly found that a certain amount of polydimethylsiloxane is added, and the weight ratio of polydimethylsiloxane to dimethiconol is (0.2-20): (0.1-10), the obtained repairing composition can reduce water loss through skin, and simultaneously has better air permeability and lubricity. The reason for this is probably that the compatibility of the polydimethylsiloxane and the dimethiconol is good, and the combined action of the polydimethylsiloxane and the dimethiconol can ensure that the skin has good air permeability and ultraviolet resistance while keeping moisture and locking water, and improve the immunity of the skin.
Preferably, the isoparaffin and the oil and fat compound thereof are one or more of isododecane, isohexadecane, cetyl ethyl hexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, and isostearyl pivalate; further preferred are mixtures of isododecane, isohexadecane, cetyl ethylhexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetrakis (ethylhexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl pivalate.
Preferably, the weight ratio of isododecane, isohexadecane, cetyl ethylhexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetrakis (ethylhexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl pivalate is (1-20): (1-20): (0.5-10): (0.5-10): (0.5-10): (0.5-10): (1-15): (1-20): (1-20): (1-20): (0.5-10); further preferably, the ratio of (5-15): (5-15): (2-8): (2-8): (2-8): (2-8): (5-12): (5-15): (5-15): (5-15): (2-8); further, the ratio is 10:10:5:5:5:5:8:10:10:10: 5.
Preferably, the weight ratio of the organic silicon compound to the isomeric alkane and the oil and fat compounds thereof is (1-2): (1-4); more preferably, it is 5: 7.
The applicant finds that the organic silicon compound, the isoalkane and the oil and fat compounds are compounded, so that the breathable protective layer can be formed, and meanwhile, the external stimulation can be resisted. The reason is that the compound of various isomeric alkanes and oil compounds thereof in the application can improve the stability of the prepared composition at high and low temperatures, has high film forming property and can also improve the smoothness and the use comfort of the composition. The applicant has found that, when the weight ratio of the organosilicon compound to the isoparaffin and the oil-and-fat compound thereof is (1-2): (1-4), the prepared composition is applied to the skin, so that the moisture loss in the skin can be reduced, the irritation can be reduced, the skin redness and sensitivity are avoided, and the high-temperature stability and the low-temperature stability of the composition are improved. In addition, isopropyl myristate can also be used for promoting the penetrating capability of the composition under the synergistic action with polydimethylsiloxane, so that the effective components can penetrate into the dermis, and the performance of the repairing composition is further improved.
Preferably, the vegetable oil and fat derivative is one or more of cetearyl glucoside, sorbitan olivine oleate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester and glyceryl ether-8 olive oil ester; further preferred are mixtures of cetearyl glucoside, sorbitan olivine oleate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, glyceryl ether-8 olive oil ester.
Preferably, the weight ratio of the cetearyl glucoside to the sorbitan olivine oleate to the glyceryl ether-8 babassu oil ester to the glyceryl ether-8 avocado oil ester to the glyceryl ether-8 olive oil ester is (0.1-5): (0.1-5): (0.1-10): (0.1-10): (0.1-10); further preferably, the ratio of (1-4): (1-4): (2-8): (2-8): (2-8); further, 3:3:5:5: 5.
In order to further improve the stability and repair effect of the composition, in some preferred embodiments, the vegetable oil and fat derivative comprises cetearyl glucoside, sorbitan olivate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, glyceryl ether-8 olive oil ester. The applicant has surprisingly found that the weight ratio of (0.1-5): (0.1-5): (0.1-10): (0.1-10): the cetearyl glucoside, sorbitan olivate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester and glyceryl ether-8 olive oil ester (0.1-10) are added into the composition as vegetable oil derivatives, so that the moisturizing effect of the composition can be enhanced, the composition is cool in texture, and meanwhile, no harmful substances such as dioxane, ethylene oxide and the like are left in the system, in addition, the addition of the glyceryl ether-8 babassu oil ester can help to improve the water solubility of other oils, and the vegetable oil derivatives synergistically improve the compounding effect of the organic silicon compound and the isoparaffin and the oil compounds thereof, so that the stability and the repairing effect of the composition are further improved.
Preferably, the plant extract is one or more of centella asiatica extract, turmeric root extract, gentian root extract, angelica dahurica extract, honeysuckle extract, seaweed extract, oat bran extract, licorice extract, purslane extract, aesculus hippocastanum extract, and citrus fruit extract; further preferred are centella asiatica extract, gentian extract, oat bran extract, aesculus hippocastanum extract, and citrus fruit extract.
Preferably, the weight ratio of the centella asiatica extract, the gentian root extract, the oat bran extract, the aesculus hippocastanum extract and the citrus fruit extract is (0.001-2): (0.005-3): (0.001-2): (0.001-2): (0.002-3); further preferably, it is (0.5-1.5): (1-2): (0.5-1.5): (0.5-1.5): (1-2); further, 1:1.5:1:1: 1.4.
In order to reduce skin irritation and improve moisture retention of the composition, in some preferred embodiments, the composition comprises plant extracts including centella asiatica extract, gentian root extract, oat bran extract, aesculus hippocastanum extract, citrus fruit extract. The applicant has unexpectedly found that the weight ratio of (0.001-2): (0.005-3): (0.001-2): (0.001-2): (0.002-3) the centella asiatica extract, the gentian root extract, the oat bran extract, the aesculus hippocastanum extract and the citrus fruit extract are added into the composition as plant extracts, wherein the effective components not only have the repairing effect on atopic dermatitis, but also can relieve the allergic phenomenon, so that the external stimulation is resisted, the anti-inflammatory and soothing effects are achieved, and the composition is suitable for most people, particularly for allergic skin. In addition, the synergistic effect of the five plant extracts can promote the secretion of epidermal cells, so that the skin aging is prevented while the grease is removed, and the skin is kept moist for a long time. However, the natural plant extract is applied to the astringent, and although the components are safe, the stability is poor.
In a second aspect, the present invention provides a method for preparing a skin barrier repair composition for protecting against external stimuli, comprising the steps of:
adding organosilicon compound, isoalkane and its oil compound, and vegetable oil derivative into emulsifying pot, heating to 75-88 deg.C, stirring, adding plant extract, and stirring.
Has the beneficial effects that:
1. selecting the following components in percentage by weight (0.2-20): (0.1-10) polydimethylsiloxane and dimethiconol as organosilicon compounds, and the prepared repairing composition has good air permeability and lubricity while reducing water loss through skin.
2. Selecting the components in the weight ratio of (1-2): the composition prepared from the organosilicon compound and the isoalkane and the oil compounds thereof in the step (1-4) is applied to skin, so that the moisture loss in the skin can be reduced, the irritation can be reduced, the skin redness and sensitivity can be avoided, and the high-temperature and low-temperature stability of the composition is improved.
3. Selecting the following components in percentage by weight (0.001-2): (0.005-3): (0.001-2): (0.001-2): (0.002-3) the centella asiatica extract, the gentian root extract, the oat bran extract, the aesculus hippocastanum extract and the citrus fruit extract are added into the composition as plant extracts, wherein the effective components not only have the repairing effect on atopic dermatitis, but also can relieve the allergic phenomenon, so that the external stimulation is resisted, the anti-inflammatory and soothing effects are achieved, and the composition is suitable for most people, particularly for allergic skin.
4. Selecting the following components in percentage by weight (0.1-5): (0.1-5): (0.1-10): (0.1-10): (0.1-10) Cetearyl glucoside, sorbitan Olive oleate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, and glyceryl ether-8 olive oil ester are added to the composition as vegetable oil derivatives, so that the moisturizing effect of the composition is enhanced, the composition has a refreshing texture, and no harmful substances such as dioxane and ethylene oxide remain in the system.
5. The addition of the glyceryl ether-8 babassu oil ester can help to improve the water solubility of other grease, and the vegetable grease derivative synergistically improves the compounding effect of the organic silicon compound, the isomane and grease compounds thereof, so that the stability and the repairing effect of the composition are further improved.
6. According to the invention, the organic silicon compound and the isomeric grease compound are compounded to form a breathable protective layer, so that the external stimulation can be resisted, the plant extract can be assisted to continuously act on sensitive skin, and a better skin repairing effect is achieved under the synergistic effect of the plant grease derivative.
7. The skin barrier repairing composition capable of resisting external stimulation, which is prepared by the invention, is suitable for various skins, such as sensitive skins, oily skins, dry skins and the like.
Detailed Description
Examples
Example 1
Example 1 provides a skin barrier repair composition for combating external irritants prepared from the following raw materials in parts by weight: 25 parts of organic silicon compound, 35 parts of isoalkane and oil compounds thereof, 10 parts of vegetable oil derivatives and 2 parts of plant extract.
The organic silicon compound is polydimethylsiloxane and dimethiconol.
The organosilicon compounds were all purchased from eastern Male chemical Co., Ltd, Guangzhou.
The weight ratio of the polydimethylsiloxane to the dimethiconol is 2: 1.
The said isoalkane and its grease compound are mixture of isododecane, isohexadecane, cetyl ethyl hexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, and isostearyl pivalate.
The weight ratio of isododecane, isohexadecane, cetyl ethyl hexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl pivalate is 10:10:5:5:5: 8:10:10:10: 5.
The vegetable oil and fat derivatives are cetearyl glucoside, sorbitan olivate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, and mixture of glyceryl ether-8 olive oil ester.
The weight ratio of cetearyl glucoside to sorbitan olive oleate to glyceryl ether-8 babassu oil ester to glyceryl ether-8 avocado oil ester to glyceryl ether-8 olive oil ester is 3:3:5:5: 5.
The cetearyl glucoside, sorbitan olivine oleate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, glyceryl ether-8 olive oil ester are all available from RES PHARMA INDUSTRIALE S.r.l.
The plant extract is centella asiatica (L.) Urban extract, radix Gentianae (Gentianascabra Bunge) root extract, oat (Avena sativa L.) bran extract, Aesculus hippocastanum (Aesculus hippocastanum L.) extract, and Mandarin orange (Citrus reticulata Blanco) fruit extract.
The weight ratio of the centella asiatica extract to the gentian scabra bunge extract to the oat bran extract to the aesculus hippocastanum extract to the citrus fruit extract is 1:1.5:1:1: 1.4.
The centella asiatica extract, the Aesculus hippocastanum extract, and the Citrus reticulata fruit extract are all purchased from Shanghai Jiajiaqiao Biotech limited.
The gentian root extract was purchased from Guangdong Dimei New materials science and technology, Inc.
The oat bran extract was purchased from lebo cosmeceutical technology (shanghai) inc.
In a second aspect, the present invention provides a method for preparing a skin barrier repair composition for combating external irritants, comprising the steps of:
adding organosilicon compound, isoalkane and its oil compound, and vegetable oil derivative into emulsifying pot, heating to 83 deg.C, stirring, adding plant extract, and stirring.
Example 2
Example 2 provides a skin barrier repair composition that is resistant to external stimuli, and the specific embodiment is the same as example 1, except that: the preparation raw materials comprise the following components in parts by weight: 30 parts of organic silicon compound, 10 parts of isoalkane and oil compounds thereof, 10 parts of vegetable oil derivatives and 2 parts of plant extract.
Example 3
Example 3 provides a skin barrier repair composition that is resistant to external stimuli, and the specific embodiment is the same as example 1, except that: the organic silicon compound is polydimethylsiloxane.
Example 4
Example 4 provides a skin barrier repair composition that is resistant to external stimuli, and the specific embodiment is the same as example 1, except that: the plant extract is herba Centellae extract, oat bran extract, Aesculus hippocastanum extract, and Mandarin orange fruit extract.
The weight ratio of the centella asiatica extract to the oat bran extract to the aesculus hippocastanum extract to the citrus fruit extract is 1:1:1: 1.4.
Example 5
Example 5 provides a skin barrier repair composition that is resistant to external stimuli, and the specific embodiment is the same as example 1, except that: the plant extract is herba Centellae extract, radix Gentianae extract, Aesculus hippocastanum extract, and Mandarin orange fruit extract.
The weight ratio of the centella asiatica extract to the gentian root extract to the aesculus hippocastanum extract to the citrus fruit extract is 1:1.5:1: 1.4.
Example 6
Example 6 provides a skin barrier repair composition that is resistant to external stimuli, and the specific embodiment differs from example 1 in that: the vegetable oil and fat derivatives are cetearyl glucoside, sorbitan olivine oleate, glyceryl ether-8 avocado oil ester, and glyceryl ether-8 olive oil ester mixture.
The weight ratio of cetearyl glucoside to sorbitan olive oleate to glyceryl ether-8 avocado oil ester to glyceryl ether-8 olive oil ester is 3:3:5: 5.
Performance test method
1. Stability test
The skin barrier repair compositions prepared in examples 1 to 6, which were resistant to external stimuli, were tested for their stability and heat resistance: keeping the temperature at 48 +/-2 ℃ for 24 hours, and comparing the performance difference after the room temperature is recovered with the performance difference before the test; cold resistance: keeping the temperature at (-18 +/-2 ℃) for 24 hours, and comparing the performance difference after room temperature is recovered with that before the test; high and low temperature cycle test: keeping the temperature at (48 +/-2 ℃) for 1 hour, then quickly keeping the temperature at (-18 +/-2 ℃) for 1 hour, and after 12 times of circulation, comparing the performance difference with that before the test after the room temperature is recovered; the results are shown in Table 1.
2. Rate of water loss through skin
30 volunteers between 20 and 50 years of age were selected and divided into 5 groups, 6 and 6 persons in each group were tested for their percutaneous water loss rates immediately after use, 14 days after use and 28 days after use by using the skin barrier repair composition for external stimulation prepared in examples 1 to 6 once in the morning and evening on the inner side of the arm, the percutaneous water loss rate of the skin was tested by using a percutaneous water loss tester, 5 groups were averaged, and the 28-day change rate (percutaneous water loss rate after use 28 days-percutaneous water loss rate immediately after use)/percutaneous water loss rate immediately after use 100% was calculated, and the measured data were recorded in table 2. A higher absolute value of the 28-day rate of change indicates a lower transdermal water loss rate after 28 days, the better the barrier repair function of the skin barrier repair composition on the stratum corneum.
3. Irritation test
The irritation of the composition was judged by lactic acid sting test. Selecting 30 volunteers aged 20-50 years, applying samples to the left side of the nose wing and applying placebo to the right side of the nose wing under the condition of not informing the volunteers of applying the samples, applying the samples to the right side of the nose wing for 1 minute, naturally airing and absorbing, applying lactic acid solution with equal concentration (2.5%) to the two side of the nose wing, grading the stinging sensation of the two side of the nose wing by the volunteers, judging that the samples in the embodiments are effective when the stinging sensation is obviously smaller than that of the placebo, and recording the results in a table 2.
TABLE 1
TABLE 2
Claims (10)
1. A skin barrier repairing composition capable of resisting external stimulation is characterized by being prepared from the following raw materials in parts by weight: 1-40 parts of organic silicon compound, 5-50 parts of isoalkane and oil compounds thereof, 0.5-15 parts of vegetable oil derivatives and 0.02-5 parts of plant extracts.
2. The skin barrier repairing composition against external stimuli according to claim 1, which is prepared from the following raw materials in parts by weight: 10-35 parts of organic silicon compound, 15-40 parts of isoalkane and oil compounds thereof, 2-13 parts of vegetable oil derivatives and 1-4 parts of plant extract.
3. A skin barrier repairing composition against external irritants according to claim 1 or 2, wherein the weight ratio of said organosilicon compound to said isoparaffin or said lipidic compound is from 1 to 2: 1-4.
4. A skin barrier repairing composition according to any of claims 1 to 3 wherein said organosilicon compound is one or more of polydimethylsiloxane, dimethiconol, octyl methicone, cyclopentadimethicone, methyl terminated silicone oil, polyether modified silicone oil.
5. A skin barrier rejuvenating composition according to claim 4 wherein said isoparaffin and said oleaginous compound are isododecane, isohexadecane, cetyl ethylhexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetrakis (ethylhexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl pivalate in admixture.
6. A skin barrier rejuvenating composition as claimed in claim 5 wherein said isododecane, isohexadecane, cetyl ethylhexanoate, isostearyl isostearate, pentaerythritol tetraisostearate, pentaerythritol tetrakis (ethylhexanoate), isononyl isononanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl pivalate are present in a weight ratio of from 1 to 20: 1-20: 0.5-10: 0.5-10: 0.5-10: 0.5-10: 1-15: 1-20: 1-20: 1-20: 0.5-10.
7. A skin barrier treatment composition according to claim 5 or 6, wherein the vegetable oil and fat derivative is cetearyl glucoside, sorbitan olivate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, glyceryl ether-8 olive oil ester, mixtures thereof.
8. A skin barrier rejuvenating composition according to claim 7 wherein the weight ratio of cetearyl glucoside, sorbitan olivate, glyceryl ether-8 babassu oil ester, glyceryl ether-8 avocado oil ester, glyceryl ether-8 olive oil ester is from 0.1 to 5: 0.1-5: 0.1-10: 0.1-10: 0.1-10.
9. The skin barrier repair composition according to any one of claims 1 to 8, wherein the plant extract is one or more of centella asiatica extract, curcuma aromatica extract, gentian root extract, angelia dahurica extract, honeysuckle extract, seaweed extract, oat bran extract, glycyrrhiza extract, purslane extract, aesculus hippocastanum extract, and citrus fruit extract.
10. A method of preparing a skin barrier rejuvenating composition according to any one of claims 1 to 9 which is resistant to external irritants, comprising the steps of:
adding organosilicon compound, isoalkane and its oil compound, and vegetable oil derivative into emulsifying pot, heating to 75-88 deg.C, stirring, adding plant extract, and stirring.
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| CN115350130A (en) * | 2022-09-22 | 2022-11-18 | 欧诗漫生物股份有限公司 | Cosmetic composition with instant relieving effect, cosmetic and preparation method thereof |
| CN115737508A (en) * | 2022-12-23 | 2023-03-07 | 蔚然(广东)生物技术有限公司 | Composition for quickly relieving fragile skin and application thereof |
| CN116726067A (en) * | 2023-07-24 | 2023-09-12 | 中国人民解放军空军特色医学中心 | Self-assembled micro-precipitation composition, skin gel thereof, preparation method and application |
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| CN111317701A (en) * | 2020-04-02 | 2020-06-23 | 广州一一生物技术有限公司 | Skin barrier repair compound, skin care emulsion and preparation method thereof |
| CN111407719A (en) * | 2020-04-02 | 2020-07-14 | 广州一一生物技术有限公司 | Skin barrier repair compound, face cream and preparation method thereof |
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| CN111317701A (en) * | 2020-04-02 | 2020-06-23 | 广州一一生物技术有限公司 | Skin barrier repair compound, skin care emulsion and preparation method thereof |
| CN111407719A (en) * | 2020-04-02 | 2020-07-14 | 广州一一生物技术有限公司 | Skin barrier repair compound, face cream and preparation method thereof |
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| CN115350130A (en) * | 2022-09-22 | 2022-11-18 | 欧诗漫生物股份有限公司 | Cosmetic composition with instant relieving effect, cosmetic and preparation method thereof |
| CN115737508A (en) * | 2022-12-23 | 2023-03-07 | 蔚然(广东)生物技术有限公司 | Composition for quickly relieving fragile skin and application thereof |
| CN116726067A (en) * | 2023-07-24 | 2023-09-12 | 中国人民解放军空军特色医学中心 | Self-assembled micro-precipitation composition, skin gel thereof, preparation method and application |
| CN116726067B (en) * | 2023-07-24 | 2024-04-16 | 中国人民解放军空军特色医学中心 | Self-assembled micro-precipitation composition, skin gel thereof, preparation method and application |
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