CN110339131A - A kind of maintenance cream and preparation method thereof - Google Patents
A kind of maintenance cream and preparation method thereof Download PDFInfo
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- CN110339131A CN110339131A CN201910751971.2A CN201910751971A CN110339131A CN 110339131 A CN110339131 A CN 110339131A CN 201910751971 A CN201910751971 A CN 201910751971A CN 110339131 A CN110339131 A CN 110339131A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A61K8/9728—Fungi, e.g. yeasts
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The present invention provides a kind of maintenance creams and preparation method thereof, its technical solution includes following component: ring five dimethyl silicone polymer // cyclohexasiloxane, phenyl trimethicone, Parleam, cetyl PEG/PPG-10/1 dimethyl silicone polymer, phytosterol/octyl dodecanol lauroyl glutamate ester, tocopherol, polyalcohol, parahydroxyacet-ophenone, EDETATE SODIUM, polyglutamic acid sodium, water, xanthan gum, acrylic acid (ester) analog copolymer sodium, ammonium acryloyl taurate/VP copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate, ethoxy urea, methyl gluceth -20, tetrahydro methylpyrimidine carboxylic acid, prebiotic component, fermentation activity ingredient etc.；The maintenance cream can be improved the water content of skin, improve the barrier protection function of skin, and impaired, fragile skin is alleviated in help, while going deep into flesh bottom, conserves layer by layer, moistens and supports brilliant white skin；Belong to technical field of skin care.
Description
Technical field
The present invention relates to a kind of maintenance creams, and the invention further relates to the preparation methods of maintenance cream, belong to skin care item technology neck
Domain.
Background technique
With the improvement of living standards, people increasingly pay close attention to the nursing of skin, the especially nursing of skin of face.Maintenance
The normal barrier function of skin is basis and the important component of skin nursing.Skin barrier refers to skin surface by sebum
The physics that film, " brick wall structure ", cuticula " sandwich " structure, cuticula keratin, lipid, corium mucopolysaccharide etc. collectively form
Property barrier, healthy skin barrier can effectively resist the injury of extraneous nuisance, stimulant, ultraviolet light to skin, have simultaneously
The effects of moisturizing, anti-inflammatory and skin are adjusted.However, stress, environmental stimuli, ultraviolet light, environmental pollution and mistake skin
The reasons such as nursing can all cause different degrees of skin barrier structure and function abnormal, so that skin self-defense scarce capacity,
Will appear the skin symptoms such as dry skin, aging, pigmentation, when serious even can cause eczema, acne, dermatitis, psoriasis,
The diseases such as ichthyosis.
The main method for the treatment of skin barrier obstacle is moisturizer treatment at present, and skin moisturizer mainly has grease envelope at present
Moisturizer, hydrophilic matrix moisture-absorption humectant, hydration moisturizer etc. are closed, but simple moisturizer treatment only treats the symptoms, and uses physics
Principle or aquation allow moisture to be retained in skin, can not solve the problems, such as skin barrier function obstruction recovery at all.
Summary of the invention
In view of the above-mentioned problems, improving flesh the first purpose of the invention is to provide a kind of water content that can be improved skin
The barrier protection function of skin, impaired, fragile skin is alleviated in help, while going deep into flesh bottom, conserves layer by layer, moistens and supports repairing for brilliant white skin
Shield cream.
A second object of the present invention is to provide the preparation methods of above-mentioned maintenance cream.
For this purpose, first technical solution provided by the present application is such that
A kind of maintenance cream, A phase, B phase, C phase, D phase, E phase raw material and its mass percent for mainly including are as follows:
A phase: ring five dimethyl silicone polymer 0.3-5.2%, cyclohexasiloxane 0.2-2.8%, the poly- trimethyl silicane oxygen of phenyl
Alkane 0.5-6%, Parleam 0.2-3%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.1-1%, plant steroid
Alcohol/octyl dodecanol lauroyl glutamate ester 0.02-1%, tocopherol (vitamin E) 0.01-0.3%；
B phase: polyalcohol 3-16%, parahydroxyacet-ophenone 0.3-1%, EDETATE SODIUM 0.01-0.2%, polyglutamic acid sodium
0.005-0.3%, water 58-75%；
C phase: xanthan gum 0.03-0.25%, acrylic acid (ester) analog copolymer sodium 0.1-0.6%, acryloyldimethyl ox sulphur
Sour ammonium/VP copolymer 0.1-0.5%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate 0.5-
2.5%；
E phase: ethoxy urea 0.5-5%, methyl gluceth -201-5%, 1,2- hexylene glycol 0.1-1%, Radix Ophiopogonis root mention
Object 0.05-0.25% is taken, thorn Cactus Pedicel extract 0.05-0.25%, kuh-seng root extract 0.05-0.25%, tetrahydro first are turned round
Yl pyrimidines carboxylic acid 0.1-2%, Poria cocos (PORIA COCOS) extract 0.001-0.015%, ginseng root extract 0.001-
0.015%, glutinous rehmannia root extract 0.001-0.015%, prebiotic component 0.3-2%, fermentation activity ingredient 0.5-2%.
Further, above-mentioned a kind of maintenance cream, ring five dimethyl silicone polymer // cyclohexasiloxane in the A phase by
Ring five dimethyl silicone polymer, cyclohexasiloxane are composed according to mass ratio 6-7:3-4.
Further, a kind of above-mentioned maintenance is newborn, sodium acrylate/sodium acryloyldimethyl taurate copolymerization in the D phase
Object // isohexadecane // Polyoxyethylene Sorbitan Monooleate is sodium acrylate/sodium acryloyldimethyl taurate copolymers, isohexadecane, gathers
The compound of sorbitol ester -80, the mass ratio of three are 7-8:4-7:1-2.
Further, above-mentioned a kind of maintenance cream, the prebiotic component in the E phase include oligofructose // glucose //
Fructose // sucrose, the combination of one of inulin // water // alpha-glucans oligosaccharides or both；Oligofructose // the grape
Sugar // fructose // sucrose is composed of oligofructose, fructose, sucrose according to mass ratio 93:3:2:2；Inulin // the water //
Alpha-glucans oligosaccharides is composed of inulin, water, alpha-glucans oligosaccharides according to mass ratio 60-80:25:1-14.
Further, above-mentioned a kind of maintenance cream, fermentation activity ingredient in the E phase by rice tunning filtrate,
Two split yeast tunning lysis object, Bacillus acidi lactici/fermented soybean Product filtrate combine according to mass ratio 8-10:3-4:1-2 and
At.
Further, above-mentioned a kind of maintenance cream, the E phase further includes the preceding temple laver amylose 0.001-0.1% of water, carnosine
0.01-0.2%, Codium Tomentosum extract 0.001-0.1%.
Further, above-mentioned a kind of maintenance cream, further includes F phase essence 0.005-0.2%.
Another technical object of the present invention is to provide a kind of preparation methods of maintenance cream, comprise the following steps:
1) A phase respectively expects to be mixed evenly spare；C phase raw material is dispersed with stirring with a small amount of polyalcohol uniformly spare in advance；
2) respectively material is added in emulsion pot B phase, is heated with stirring to 90 DEG C, stirring and dissolving cools down afterwards completely, cools to 75 DEG C again
C phase is added, stirs homogeneous, is uniformly dispersed；
3) A phase, D are added in emulsion pot, emulsifying after stirring, then vacuum heat-preserving 15 minutes, defoaming is complete
After cool down；
4) 45 DEG C are cooled to, E, F phase is added and respectively expects, stirs evenly, to version, after detection is qualified, discharging obtains maintenance cream
Liquid.
A kind of the effect of technical solution of the present invention carboxylic acid of methylpyrimidine containing tetrahydro, it is derived from high Halophiles body at
Point, by the natural component of one kind 100% that biofermentation technique obtains, water loss can be reduced with moisturizing water lock；Repair flesh
The invasion of skin cell ability, combating microorganisms and anaphylactogen, stable protein, protected protein matter is from decomposing, to stablize thin
After birth, protection cell normal growth and metabolism.
Technical solution of the present invention contains prebiotic component, which includes oligofructose // glucose // fructose // sugarcane
Sugar and (or) inulin // water // alpha-glucans oligosaccharides, prebiotics supplement active matter and nutrients as the external source of probiotics, by skin
The saprophytic flora (probiotics) of skin absorbs, but not is utilized by pathogen (harmful bacteria), so that Reverse transcriptase pathogen, reaches
Protection, the purpose for repairing and strengthening skin flora (confrontation is extraneous stress be with the first barrier of influence), prevent extraneous invasion (dirty
Dye, pathogen) caused by injure.
The fermentation activity ingredient that technical solution of the present invention contains splits yeast tunning by rice tunning filtrate, two
Lysis, Bacillus acidi lactici/soya-bean milk tunning filtrate are composed, and using the principle of simulation of human body, simulate digestion
Running, natural component is fermented, the natural moisturizing factor of resulting natural bioactive substances and human body is quite similar, according to
The principle of " similar compatibility " can enter skin cell quickly through cell membrane, open skin moisturizing channel, activate aquaporin egg
White, efficient replenishing water and preserving moisture nourishes skin, and has both the multi-efficiencies such as whitening, anti-ageing, reparation.
Technical solution of the present invention also added natural whitening composition " Qiong Yufang ", by ginseng root extract, Radix Rehmanniae
Extract and tuckahoe extracts composition, have very high elimination efficiency to free radical, at fibre caused by reducing due to itself and the external world
The aging for tieing up cell, inhibits the activity of tyrosinase, there is good anti-aging, whitening, the maintenance effect for highlighting skin and moisturizing.
Technical solution of the present invention also added Radix Ophiopogonis root extract, turn round thorn Cactus Pedicel extract, kuh-seng root extract,
Bergamot Mint Extract restrains pore, maintenance damaged cell；Inhibit TYR enzyme activity, reduces melanin production；Antibacterial anti-anaphylaxis,
Alleviate scytitis, prevents skin aging caused by environmental pollution.
Compared with prior art, technical solution provided by the present application has following technological merit:
1, maintenance cream of the invention is strong using skin Tiny ecosystem by combining prebiotic component with fermentation activity ingredient
Health technology inhibits the growth of skin surface harmful bacteria from biological angle, while supplementing to skin and being mentioned by fermentating metabolism product
The multiple nutritional components of confession, moisturizing promote cell repair, promote the barrier protection function of skin, and help is alleviated impaired, crisp
Weak skin.
2, maintenance cream of the invention compounds tetrahydro methylpyrimidine carboxylic acid with prebiotics, fermentation activity ingredient, and three kinds
Main component synergistic effect is further helped to have the function that moisturizing water lock, repair skin cell ability, stabilizing cell membrane
Help the invasion in sensitive skin confrontation outside contamination source.
3, the other compositions that maintenance cream of the invention also contains such as ginseng root extract, glutinous rehmannia root extract, Poria cocos extracts
Object, Radix Ophiopogonis root extract turn round thorn Cactus Pedicel extract, kuh-seng root extract, the preceding temple laver amylose of water, carnosine, fur pine algae
Extract etc., so that other than maintenance cream is in addition to the moisturizing maintenance the effect of skin can be highlighted with whitening.
Specific embodiment
With reference to embodiment, claim of the invention is described in further detail, but do not constituted
To any restrictions of invention.
It should be noted that the present invention provides what raw material was obtained by commercial channel purchase.
Embodiment 1
A kind of maintenance cream provided by the invention, is made of, each component and its quality A phase, B phase, C phase, D phase, E phase raw material
Percentage is as follows:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 0.5%, phenyl trimethicone 6%, hydrogenation are poly-
Isobutene 0.2%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.1%, phytosterol/octyl dodecanol lauroyl paddy
Propylhomoserin ester 1%, tocopherol (vitamin E) 0.01%；
B phase: polyalcohol 10%, parahydroxyacet-ophenone 0.3%, EDETATE SODIUM 0.2%, polyglutamic acid sodium 0.005%, water
70.34%；
C phase: xanthan gum 0.2%, acrylic acid (ester) analog copolymer sodium 0.15%, ammonium acryloyldime-thyltaurate/VP is total
Polymers 0.5%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // polysorbate-
800.5%；
E phase: ethoxy urea 0.5%, methyl gluceth -204%, 1,2- hexylene glycol 1%, Radix Ophiopogonis root extract
0.05%, thorn Cactus Pedicel extract 0.05% is turned round, kuh-seng root extract 0.05%, tetrahydro methylpyrimidine carboxylic acid 2%, Poria cocos mentions
Take object 0.015%, ginseng root extract 0.015%, glutinous rehmannia root extract 0.015%, prebiotic component 0.3%, fermentation activity
Ingredient 2%.
In above-described embodiment:
Ring five dimethyl silicone polymer // cyclohexasiloxane in A phase is by ring five dimethyl silicone polymer, cyclohexasiloxane
It is formed according to mass ratio 6:3.
Sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate is third in D phase
Olefin(e) acid sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three
For 7:4:2；
Prebiotic component in E phase is oligofructose // glucose // fructose // sucrose, by oligofructose, fructose, sucrose
It is composed according to mass ratio 93:3:2:2；
Fermentation activity ingredient in E phase splits yeast tunning lysis object, lactic acid bar by rice tunning filtrate, two
Bacterium/fermented soybean Product filtrate is composed according to mass ratio 8:3:2.
Embodiment 2
A kind of maintenance cream provided by the invention, is made of, each component and its quality A phase, B phase, C phase, D phase, E phase raw material
Percentage is as follows:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 6%, phenyl trimethicone 1.5%, hydrogenation are poly-
Isobutene 1%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 1%, phytosterol/octyl dodecanol lauroyl glutamate
Ester 0.02%, tocopherol (vitamin E) 0.3%；
B phase: polyalcohol 3%, parahydroxyacet-ophenone 1%, EDETATE SODIUM 0.01%, polyglutamic acid sodium 0.3%, water
74.69%；
C phase: xanthan gum 0.03%, acrylic acid (ester) analog copolymer sodium 0.6%, ammonium acryloyldime-thyltaurate/VP is total
Polymers 0.1%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate 2%；
E phase: ethoxy urea 5%, methyl gluceth -201%, 1,2- hexylene glycol 0.1%, Radix Ophiopogonis root extract
0.25%, turn round thorn Cactus Pedicel extract 0.25%, kuh-seng root extract 0.25%, tetrahydro methylpyrimidine carboxylic acid 0.1%, Poria cocos
Extract 0.001%, ginseng root extract 0.001%, glutinous rehmannia root extract 0.001%, prebiotic component 1%, fermentation activity
Ingredient 0.5%.
In above-described embodiment:
Ring five dimethyl silicone polymer // cyclohexasiloxane in A phase is by ring five dimethyl silicone polymer, cyclohexasiloxane
It is composed according to mass ratio 7:4.
Sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate is third in D phase
Olefin(e) acid sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three
For 8:7:1.
Prebiotic component in E phase is inulin // water // alpha-glucans oligosaccharides, by inulin, water, alpha-glucans oligosaccharides, according to
Mass ratio 60:25:14 is composed.
For fermentation activity ingredient in E phase by rice tunning filtrate, two split yeast tunning lysis object, lactic acid bar
Bacterium/fermented soybean Product filtrate is composed according to mass ratio 10:4:1.
Embodiment 3
A kind of maintenance cream provided by the invention, is made of, each component and its quality A phase, B phase, C phase, D phase, E phase raw material
Percentage is as follows:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 8%, phenyl trimethicone 0.5%, hydrogenation are poly-
Isobutene 3%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.6%, phytosterol/octyl dodecanol lauroyl paddy ammonia
Acid esters 0.2%, tocopherol (vitamin E) 0.1%；
B phase: polyalcohol 16%, parahydroxyacet-ophenone 0.5%, EDETATE SODIUM 0.1%, polyglutamic acid sodium 0.1%, water
58.37%；
C phase: xanthan gum 0.25%, acrylic acid (ester) analog copolymer sodium 0.1%, ammonium acryloyldime-thyltaurate/VP is total
Polymers 0.2%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // polysorbate-
802.5%；
E phase: ethoxy urea 2%, methyl gluceth -202%, 1,2- hexylene glycol 0.5%, Radix Ophiopogonis root extract
0.15%, turn round thorn Cactus Pedicel extract 0.15%, kuh-seng root extract 0.15%, tetrahydro methylpyrimidine carboxylic acid 0.8%, Poria cocos
Extract 0.01%, ginseng root extract 0.01%, glutinous rehmannia root extract 0.01%, prebiotic component 2%, fermentation activity ingredient
1.5%；
F phase: essence 0.2%.
In above-described embodiment:
Ring five dimethyl silicone polymer // cyclohexasiloxane in A phase is by ring five dimethyl silicone polymer, cyclohexasiloxane
It is composed according to mass ratio 6:4.
Sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate is third in D phase
Olefin(e) acid sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three
For 7:4:1.
Prebiotic component in E phase includes 1% oligofructose // glucose // fructose // sucrose, and 1% inulin //
Water // alpha-glucans oligosaccharides；Oligofructose // glucose // fructose // the sucrose is by oligofructose, fructose, sucrose according to matter
Amount is composed than 93:3:2:2；Inulin // water // alpha-glucans the oligosaccharides by inulin, water, alpha-glucans oligosaccharides, according to
Mass ratio 80:25:1 is composed.
For fermentation activity ingredient in E phase by rice tunning filtrate, two split yeast tunning lysis object, lactic acid bar
Bacterium/fermented soybean Product filtrate is composed according to mass ratio 9:3.5:1.
Embodiment 4
A kind of maintenance cream provided by the invention, is made of, each component and its quality A phase, B phase, C phase, D phase, E phase raw material
Percentage is as follows:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 2%, phenyl trimethicone 2%, hydrogenation gather different
Butylene 0.5%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.4%, phytosterol/octyl dodecanol lauroyl paddy ammonia
Acid esters 0.5%, tocopherol (vitamin E) 0.05%；
B phase: polyalcohol 12%, parahydroxyacet-ophenone 0.6%, EDETATE SODIUM 0.05%, polyglutamic acid sodium 0.12%, water
68.733%；
C phase: xanthan gum 0.18%, acrylic acid (ester) analog copolymer sodium 0.25%, ammonium acryloyldime-thyltaurate/VP is total
Polymers 0.3%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // polysorbate-
801.5%；
E phase: ethoxy urea 1%, methyl gluceth -205%, 1,2- hexylene glycol 0.3%, Radix Ophiopogonis root extract
0.1%, thorn Cactus Pedicel extract 0.1% is turned round, kuh-seng root extract 0.1%, tetrahydro methylpyrimidine carboxylic acid 1.2%, Poria cocos mentions
Take object 0.005%, ginseng root extract 0.005%, glutinous rehmannia root extract 0.005%, prebiotic component 2%, fermentation activity at
Point 0.8%, the preceding temple laver amylose 0.001% of water, carnosine 0.2%, Codium Tomentosum extract 0.001%.
In above-described embodiment:
Ring five dimethyl silicone polymer // cyclohexasiloxane in A phase is by ring five dimethyl silicone polymer, cyclohexasiloxane
It is composed according to mass ratio 7:3.
Sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate is third in D phase
Olefin(e) acid sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three
For 7:6:2.
Prebiotic component in E phase is oligofructose // glucose // fructose // sucrose, by oligofructose, fructose, sucrose
It is composed according to mass ratio 93:3:2:2.
For fermentation activity ingredient in E phase by rice tunning filtrate, two split yeast tunning lysis object, lactic acid bar
Bacterium/fermented soybean Product filtrate is composed according to mass ratio 10:3:2.
Embodiment 5
A kind of maintenance cream provided by the invention, is made of, each component and its quality A phase, B phase, C phase, D phase, E phase raw material
Percentage is as follows:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 4%, phenyl trimethicone 1%, hydrogenation gather different
Butylene 2.5%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.5%, phytosterol/octyl dodecanol lauroyl paddy ammonia
Acid esters 0.3%, tocopherol (vitamin E) 0.2%；
B phase: polyalcohol 6%, parahydroxyacet-ophenone 0.8%, EDETATE SODIUM 0.12%, polyglutamic acid sodium 0.2%, water
71.679%；
C phase: xanthan gum 0.05%, acrylic acid (ester) analog copolymer sodium 0.15%, ammonium acryloyldime-thyltaurate/VP is total
Polymers 0.35%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate 1%；
E phase: ethoxy urea 4%, methyl gluceth -203%, 1,2- hexylene glycol 0.2%, Radix Ophiopogonis root extract
0.2%, turn round thorn Cactus Pedicel extract 0.2%, kuh-seng root extract 0.2%, tetrahydro methylpyrimidine carboxylic acid 1%, Poria cocos extraction
Object 0.012%, ginseng root extract 0.012%, glutinous rehmannia root extract 0.012%, prebiotic component 1.1%, fermentation activity at
Point 1%, the preceding temple laver amylose 0.1% of water, carnosine 0.01%, Codium Tomentosum extract 0.1%；
F phase: essence 0.005%.
In above-described embodiment:
Ring five dimethyl silicone polymer // cyclohexasiloxane in A phase is by ring five dimethyl silicone polymer, cyclohexasiloxane
It is composed according to mass ratio 7:4.
Sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate is third in D phase
Olefin(e) acid sodium/sodium acryloyldimethyl taurate copolymers, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three
For 8:6:1.
Prebiotic component in E phase includes 0.6% oligofructose // glucose // fructose // sucrose, 0.5% chrysanthemum
Powder // water // alpha-glucans oligosaccharides；Oligofructose // glucose // fructose // the sucrose is pressed by oligofructose, fructose, sucrose
It is composed according to mass ratio 93:3:2:2；Inulin // water // alpha-glucans the oligosaccharides is pressed by inulin, water, alpha-glucans oligosaccharides
It is composed according to mass ratio 70:25:5.
For fermentation activity ingredient in E phase by rice tunning filtrate, two split yeast tunning lysis object, lactic acid bar
Bacterium/fermented soybean Product filtrate is composed according to mass ratio 9:3.5:1.
Embodiment 1-5 maintenance cream the preparation method is as follows:
1) A phase respectively expects to be mixed evenly spare；C phase raw material is dispersed with stirring with a small amount of polyalcohol uniformly spare in advance；
2) respectively material is added in emulsion pot B phase, is heated with stirring to 90 DEG C, stirring and dissolving cools down afterwards completely, cools to 75 DEG C again
C phase is added, stirs homogeneous, is uniformly dispersed；
3) A phase, D are added in emulsion pot, emulsifying after stirring, then vacuum heat-preserving 15 minutes, defoaming is complete
After cool down；
4) cool to 45 DEG C, be added E, F phase (without containing when do not add then) each material, stir evenly, to version, detection is qualified
Afterwards, it discharges, obtains maintenance lotion.
In order to more preferably illustrate effect of the invention, the comparison of experimental program of the present invention in R&D process is given below
Example.
Comparative example 1
Tetrahydro methylpyrimidine carboxylic acid and prebiotic component are replaced with the water of equivalent, other materials and its content and embodiment 5
In substance and its content it is identical.
Comparative example 2
Prebiotic component and fermentation activity ingredient are replaced with the water of equivalent, in other materials and its content and embodiment 5
Substance and its content are identical.
Comparative example 3
Tetrahydro methylpyrimidine carboxylic acid and fermentation activity ingredient are replaced with the water of equivalent, other materials and its content and embodiment
Substance and its content in 5 is identical.
Comparative example 4
It is replaced with the fermentation activity ingredient of equivalent in the prebiotic component of equivalent, other materials and its content and embodiment 5
Substance and its content it is identical.
Comparative example 5
The fermentation activity ingredient of equivalent, other materials and its content and implementation are replaced with the tetrahydro methylpyrimidine carboxylic acid of equivalent
Substance and its content in example 5 is identical.
The test effect of maintenance cream provided by the present application is given below in the advantages of in order to prove technical solution provided by the present application
Fruit example.
1, test object and grouping
50 subjects are chosen, men and women each 25, the age 20-45 years old, are randomly divided into 10 groups, every group of 5 people, respectively in face
Using the product of embodiment 1-5 and comparative example 1-5, a skin test is respectively being carried out before and after continuous use 28 days.
2, test index and method
1. moisture content of skin:
Moisture content of skin can reflect the performance of keeping humidity of product.Using moisture of skin tester (Corneometer CM825,
CK facial moisture content of skin) is measured.
2. skin barrier function
Refer to through transepidermal water loss value (Transepidermal Water Loss, TEWL) and to be evaporated by epidermis
Moisture, TEWL are the important parameters for assessing skin barrier function, and skin barrier is more intact, and TEWL value is lower.Utilize skin screen
Hinder aptitude tests instrument (Tewameter TM300, CK) and measures TEWL value.
3. skin brightness changes
ITA ° of value is skin subjects type angle, is the numerical value of characterization skin brightness relevant to L* and b*.ITA ° of value is got over
Greatly, skin is brighter, conversely, skin is more obscure.It is popped one's head in and is tested with skin chromatism test, and the skin of face is calculated
ITA°。
The water content (A.U.) of skin before and after 1 use of table
TWEL value (the g/m of skin before and after 2 use of table2h)
| Group | Before use | After use | Changing value |
| Embodiment 1 | 16.5 | 12 | 4.5 |
| Embodiment 2 | 16.3 | 12.1 | 4.2 |
| Embodiment 3 | 17.0 | 12.0 | 5.0 |
| Embodiment 4 | 16.6 | 10.2 | 6.4 |
| Embodiment 5 | 17.7 | 10.8 | 6.9 |
| Comparative example 1 | 16.1 | 14.6 | 1.5 |
| Comparative example 2 | 15.6 | 14.6 | 1.0 |
| Comparative example 3 | 15.9 | 14.5 | 1.4 |
| Comparative example 4 | 16.5 | 10.9 | 5.6 |
| Comparative example 5 | 17.2 | 11.2 | 6.0 |
ITA ° of value of skin before and after 3 use of table
From table 1, table 2 and table 3 it is found that the TEWL value of skin of face is obvious after using the maintenance cream of 1-5 of the embodiment of the present invention
Decline, moisture content of skin and ITA ° of value obviously increase, and illustrate that the water content of skin, maintenance skin can be improved in maintenance cream of the invention
Skin barrier function, and improve the brightness of skin, have effects that good moisturizing, maintenance and skin lightening.
Comparative example 1-3 and embodiment 1-5 compare, it is known that when maintenance cream of the invention contains only tetrahydro methylpyrimidine carboxylic
Acid, prebiotic component, in fermentation activity ingredient any one when, the changing value of the TEWL value of skin, water content and ITA ° of value
It is all decreased obviously, and the sum of the changing value of comparative example 1-3 is below the changing value of embodiment 1-5；In addition, comparative example 4,5 and reality
It applies example 5 to compare, when replacing another kind with ingredient a kind of in tetrahydro methylpyrimidine carboxylic acid, prebiotic component, fermentation activity ingredient
When ingredient, the changing value of the TEWL value of skin, water content and ITA ° of value is below the changing value of embodiment 5, illustrates only to work as
These three ingredients could generate good collaboration moisturizing after adding compounding simultaneously, improve skin barrier function, reach good
Maintenance effect, while effective bright color.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of maintenance cream, which is characterized in that A phase, B phase, C phase, D phase, E phase raw material, each component and its matter for mainly including
It is as follows to measure percentage:
A phase: ring five dimethyl silicone polymer // cyclohexasiloxane 0.5-8%, phenyl trimethicone 0.5-6%, hydrogenation
Polyisobutene 0.2-3%, cetyl PEG/PPG-10/1 dimethyl silicone polymer 0.1-1%, the phytosterol/octyl dodecanol moon
Osmanthus acyl glutamate 0.02-1%, tocopherol 0.01-0.3%；
B phase: polyalcohol 3-16%, parahydroxyacet-ophenone 0.3-1%, EDETATE SODIUM 0.01-0.2%, polyglutamic acid sodium 0.005-
0.3%, water 58-75%；
C phase: xanthan gum 0.03-0.25%, acrylic acid (ester) analog copolymer sodium 0.1-0.6%, ammonium acryloyldime-thyltaurate/
VP copolymer 0.1-0.5%；
D phase: sodium acrylate/sodium acryloyldimethyl taurate copolymers // isohexadecane // Polyoxyethylene Sorbitan Monooleate 0.5-
2.5%；
E phase: ethoxy urea 0.5-5%, methyl gluceth -201-5%, 1,2- hexylene glycol 0.1-1%, Radix Ophiopogonis root extract
0.05-0.25% is turned round and is pierced Cactus Pedicel extract 0.05-0.25%, kuh-seng root extract 0.05-0.25%, and tetrahydro methyl is phonetic
Pyridine carboxylic acid 0.1-2%, tuckahoe extracts 0.001-0.015%, ginseng root extract 0.001-0.015%, glutinous rehmannia root extract
0.001-0.015%, prebiotic component 0.3-2%, fermentation activity ingredient 0.5-2%.
2. a kind of maintenance cream according to claim 1, which is characterized in that five polydimethylsiloxanes of ring in the A phase
Alkane // cyclohexasiloxane is composed of ring five dimethyl silicone polymer, cyclohexasiloxane according to mass ratio 6-7:3-4.
3. a kind of maintenance cream according to claim 1, which is characterized in that sodium acrylate/acryloyl diformazan in the D phase
Base Taurate Copolymer // isohexadecane // Polyoxyethylene Sorbitan Monooleate is sodium acrylate/sodium acryloyldimethyl taurate copolymerization
Object, isohexadecane, Polyoxyethylene Sorbitan Monooleate compound, the mass ratio of three is 7-8:4-7:1-2.
4. a kind of maintenance cream according to claim 1, which is characterized in that the prebiotic component in the E phase includes oligomeric
Fructose // glucose // fructose // sucrose, the combination of one of inulin // water // alpha-glucans oligosaccharides or both.
5. a kind of maintenance cream according to claim 3, which is characterized in that the oligofructose // glucose // fructose //
Sucrose is composed of oligofructose, glucose, fructose, sucrose according to mass ratio 93:3:2:2；Inulin // water // the α-
Glucan oligosaccharides is composed of inulin, water, alpha-glucans oligosaccharides according to mass ratio 60-80:25:1-14.
6. a kind of maintenance cream according to claim 1, which is characterized in that the fermentation activity ingredient in the E phase is by rice
Tunning filtrate, two split yeast tunning lysis object, and Bacillus acidi lactici/fermented soybean Product filtrate is according to mass ratio 8-10:
3-4:1-2 is composed.
7. a kind of maintenance cream according to claim 1, which is characterized in that the E phase further includes the preceding temple laver amylose of water
0.001-0.1%, carnosine 0.01-0.2%, Codium Tomentosum extract 0.001-0.1%.
8. a kind of maintenance cream according to any one of claims 1 to 6, which is characterized in that further include F phase essence 0.005-
0.2%.
9. a kind of preparation method of maintenance cream described in claim 1, which comprises the steps of:
1) A phase respectively expects to be mixed evenly spare；C phase raw material is dispersed with stirring with a small amount of polyalcohol uniformly spare in advance；
2) respectively material is added in emulsion pot B phase, is heated with stirring to 90 DEG C, stirring and dissolving cools down afterwards completely, cools to 75 DEG C and adds C
Phase stirs homogeneous, is uniformly dispersed；
3) A phase, D are added in emulsion pot, emulsifying after stirring, then vacuum heat-preserving 15 minutes, drop after defoaming completely
Temperature；
4) 45 DEG C are cooled to, E is added and respectively expects, stirs evenly, to version, after detection is qualified, discharging obtains maintenance lotion.
10. a kind of preparation method of maintenance cream according to claim 9, which is characterized in that further include that F is added in step 4)
Phase essence stirs evenly.
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| CN110840787A (en) * | 2019-11-19 | 2020-02-28 | 天津郁美净集团有限公司 | Skin care active composition with acne removing and blemish repairing effects and application thereof |
| CN111568801A (en) * | 2020-05-07 | 2020-08-25 | 广州蛋壳网络科技有限公司 | Polysaccharide-containing moisturizing and oil-controlling composition and application thereof in cosmetics |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176567A (en) * | 2016-08-24 | 2016-12-07 | 广东芭薇生物科技股份有限公司 | A kind of double-deck facial treatment milk and preparation method thereof |
-
2019
- 2019-08-15 CN CN201910751971.2A patent/CN110339131B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176567A (en) * | 2016-08-24 | 2016-12-07 | 广东芭薇生物科技股份有限公司 | A kind of double-deck facial treatment milk and preparation method thereof |
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| CN113456573A (en) * | 2021-07-06 | 2021-10-01 | 广州集妍化妆品科技有限公司 | Composition, moisturizing and makeup holding foundation liquid and preparation method thereof |
| CN113456573B (en) * | 2021-07-06 | 2023-02-17 | 广州集妍化妆品科技有限公司 | Composition, moisturizing and makeup holding foundation liquid and preparation method thereof |
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| CN115212160A (en) * | 2022-09-19 | 2022-10-21 | 同芙集团(中国)股份有限公司 | Moisturizing facial mask with plant extract essence |
| CN115778879A (en) * | 2022-12-23 | 2023-03-14 | 蔚然(广东)生物技术有限公司 | Composition capable of continuously relieving and repairing fragile skin and preparation method thereof |
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